CN110179730B - Repair cream - Google Patents

Repair cream Download PDF

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CN110179730B
CN110179730B CN201910531364.5A CN201910531364A CN110179730B CN 110179730 B CN110179730 B CN 110179730B CN 201910531364 A CN201910531364 A CN 201910531364A CN 110179730 B CN110179730 B CN 110179730B
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parts
extract
repair
component
cream
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CN110179730A (en
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李加前
冯俞钦
臧炜
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Guangdong Momo Cosmetics Co ltd
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Guangdong Momo Cosmetics Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention provides a non-wrinkle repair cream which comprises a repair active component, an auxiliary active component and deionized water, and further comprises hydrogenated lecithin and glycolipid which are used as emulsifying components, wherein the weight ratio of the hydrogenated lecithin to the glycolipid is 0.7-1.2: 1-1.4. According to the wrinkle-free repair cream provided by the invention, the emulsifying capacity of natural surface active substances is improved by the compound emulsifying component, the cream with uniform emulsification, fine skin feel and high stability can be obtained, the cream has good permeability and is absorbed more quickly, the compound emulsifying component and the repair active component have a synergistic effect, the skin elasticity can be obviously improved, and the repair cream can be obtained through sensory evaluation, has an obvious moisturizing and penetrating effect and no sensitization phenomenon, can effectively smooth fine lines, reduce dry lines and wrinkles and slow down skin aging after being used, and effectively improves the phenomena of dryness and relaxation, so that the skin is moist, smooth and elastic.

Description

Repair cream
Technical Field
The invention relates to the technical field of cosmetics, in particular to a wrinkle-free repair cream.
Background
The repair cream is a cream cosmetic with repair function to skin, has good skin moistening effect and humidity regulating effect, and can keep skin moist. Various ethers or hydroxyl emulsifiers (such as laureth, fatty alcohol polyoxyethylene ether, ceteareth, cetearyl alcohol and polyethylene glycol) and traditional chemical preservatives (such as p-hydroxybenzyl ester, propyl p-hydroxybenzoate and the like) are added into the existing cream products so as to emulsify the water phase and the oil phase in the raw materials and ensure stable preservation.
The addition of the ether or hydroxyl emulsifier and the chemical preservative has irritation to sensitive muscles or skin damaged by sunlight, and the soothing and repairing effects of the repairing cream mainly having the effects of anti-allergy, soothing and repairing skin damage can be reduced, so that the development trend of a natural, non-toxic, low-irritation, stable in property and biodegradable novel natural emulsifying component becomes a daily product. However, a single natural emulsifying component has weak emulsifying capacity, is suitable for preparing aqueous cosmetics or micro-emulsion type cosmetics with small particle size, has poor emulsifying effect when preparing a cream, is easy to generate unstable phenomena such as oil-water separation and the like, and is difficult to ensure the stability and sensory quality of the cream.
Meanwhile, in order to achieve the effect of repairing skin injury, natural ingredients with remarkable repairing effect, such as plant extracts, microbial fermentation products and the like, are usually added into the repairing cream as skin repairing factors, and the conventional emulsifier has poor biocompatibility with the natural ingredients and does not have the synergistic effect of improving the repairing effect.
Disclosure of Invention
In order to solve the problems, the invention aims to provide the wrinkle-free repair cream which has stable emulsification effect, does not stimulate the skin, can synergistically and remarkably improve the repair effect of resisting wrinkles and removing wrinkles, and is particularly suitable for sensitive skin or skin with more fine wrinkles.
On one hand, the invention provides a wrinkle-free anti-allergy repair cream which comprises the following raw materials in parts by weight:
15-40 parts of a repairing active component; 18-35 parts of auxiliary effect component; 2-5 parts of an emulsifying component; the balance of deionized water; wherein the repairing active component comprises one or more of oat glucan, centella asiatica extract, evening primrose seed extract, olive fruit extract and shea butter; the auxiliary active components comprise one or more of purslane extract, black Shengma root extract, glycerol, propylene glycol, sodium hyaluronate and hydrolyzed collagen; the auxiliary components also comprise an antioxidant component, an anti-allergy component and a thickening component; the emulsifying component comprises hydrogenated lecithin and glycolipid.
The wrinkle-free repair cream containing the components is added with a large amount of repair active components and anti-allergy moisture-retention components, wherein oligopeptide-1, oligopeptide-2, dragon's blood, horse fat, oat glucan, centella asiatica extract, evening primrose seed extract, olive fruit extract and shea butter have good repair effects of resisting wrinkles and ageing and smoothing fine wrinkles; the purslane extract and the black Shengma root extract are antibacterial components extracted from pure plants and have obvious antibacterial effect; and natural antioxidant, anti-allergy and moisturizing components are added, so that the affinity with the skin can be improved. In addition, the repairing cream does not use the traditional synthetic emulsifier, but adopts the combination of the surface active substance hydrogenated lecithin of natural sources and the biological surface active substance glycolipid, so that the cream with stable emulsifying effect and better picking and spreading performance can be obtained.
Further, the emulsifying component includes 0.8-1 part of hydrogenated lecithin and 1.1-1.3 parts of glycolipid, preferably 0.8 part of hydrogenated lecithin and 1.2 parts of glycolipid.
Still further, the glycolipid is selected from one or more of sophorolipid, algal glycolipid, algal protein glycolipid, preferably algal protein glycolipid.
Further, the emulsifying component also comprises 0.3-0.7 part of phytosterol, wherein the phytosterol is selected from one or more of sitostanol, β -sitosterol, stigmasterol, campesterol, brassicasterol and avocado sterol, and preferably at least comprises β -sitosterol.
The phytosterol also has surface activity, and the phytosterol is compounded with the hydrogenated lecithin and the glycolipid, so that the emulsification effect of the repair cream is further enhanced, and the synergistic effect of improving the effect of the repair cream can be achieved. Experimental data show that when the emulsified component compounded by the hydrogenated lecithin, the glycolipid and the phytosterol is applied to the repair cream, the skin elasticity can be obviously improved and fine wrinkles can be reduced after the emulsified component is continuously used for 6 weeks.
Further, the phytosterols include β -sitosterol, brassicasterol, and avocado sterol.
Furthermore, β -sitosterol, brassicasterol and avocado sterol in the phytosterol are 55-95%, 5-20% and 25-30% by mass respectively, preferably β -sitosterol is 55%, 70% or 95% by mass, brassicasterol is 5% or 25% by mass and avocado sterol is 25% or 30% by mass.
Further, the repair cream comprises the following components in parts by weight: the repairing active component comprises: oligopeptide-10.5-2 parts, oligopeptide-20.8-1.5 parts, dragon's blood 3-6 parts, horse fat 5-8 parts, oat glucan 6-10 parts, centella asiatica extract 1.5-2 parts, evening primrose seed extract 0.8-1.2 parts, olive fruit extract 1.2-2.5 parts, and shea butter 3-5 parts; the auxiliary components comprise: 1-2.5 parts of purslane extract, 1-2.5 parts of black Shengma root extract, 6-10 parts of antioxidant component, 1.5-3 parts of anti-allergic component, 0.2-0.5 part of thickening component, 2-3 parts of glycerol, 5-8 parts of propylene glycol, 0.5-1 part of sodium hyaluronate and 1-3 parts of hydrolyzed collagen.
Further, the antioxidant component comprises one or more of tea polyphenol, grape extract, rosemary, lutein, vitamin A, vitamin C, and tocotrienol; the anti-allergy component is one or more selected from chamomile extract, burdock root, aloe extract, glycyrrhizic acid and nobiletin; the thickening component is one or more selected from carbomer, xanthan gum and hydrogenated castor oil.
In one embodiment, the antioxidant component comprises 2 parts of rosemary, 4 parts of tea polyphenol and 0.8 part of tocotrienol; the anti-allergy component comprises 0.8 part of chamomile extract, 1 part of burdock root and 0.7 part of saligenin; the thickening component is preferably 0.4 parts xanthan gum.
Further, 0.5-1.5 parts of pH regulator is also included; preferably, the pH regulator is citric acid; more preferably, the pH value of the repair cream is 5.8-6.5, and a proper amount of citric acid is added for regulation.
In another aspect, the invention also provides the application of the above-mentioned wrinkle-free repair cream in improving skin elasticity, or in preparing an article for improving skin elasticity.
On the other hand, the invention also provides a preparation method of the non-striation repair cream, which comprises the following steps:
adding oligopeptide-1, oligopeptide-2, oat glucan, centella asiatica extract, purslane extract, black hibiscus cannabinus extract, antioxidant component, anti-allergy component, sodium hyaluronate, hydrolyzed collagen, glycolipid, propylene glycol and water into a water phase pot, stirring and mixing uniformly, and heating to 70-85 ℃ to obtain a water phase material; sequentially adding dragon blood, horse fat, evening primrose seed extract, olive fruit extract, shea butter and hydrogenated lecithin into an oil phase pot, heating to 70-85 ℃, and uniformly stirring and mixing to obtain an oil phase material; pumping the water phase material into an emulsifying pot, pumping the oil phase material while stirring and homogenizing, adding the phytosterol, homogenizing at 70-85 ℃, and keeping the temperature for 60 minutes to obtain the plant sterol-containing emulsion.
Further, the method needs to add citric acid to adjust the pH to 5.8-6.5 after homogenizing and heat preservation.
In the components of the wrinkle-free repair cream provided by the invention, the core components showing the repair effect are oligopeptide-1, oligopeptide-2, dragon's blood and horse fat, wherein the oligopeptide-1 has the effects of quickly repairing damaged skin, improving the repair and nursing of the skin, smoothing wrinkles, tightening the skin and reducing the formation of scars; oligopeptide-2 has effects of promoting wound healing and tissue repair, promoting tissue regeneration, promoting synthesis of elastic fiber and collagen, and has obvious and lasting anti-wrinkle effect; sanguis Draxonis has effects in astringing, stopping bleeding, promoting blood circulation, dispelling blood stasis, promoting metabolism, accelerating lymph reflux, and promoting oligopeptide molecular absorption; horse fat has effects of keeping moisture, moistening, rapidly permeating, and resisting oxidation.
The invention can bring the following beneficial effects:
1. the application provides a no line repair cream, its repair active ingredient is plant extract or microorganism fermentation product, and anti-wrinkle repair effect is showing, uses the natural surface active substance that can thoroughly biodegradable simultaneously, and the security is high nonirritant, has avoided the irritability of traditional emulsifier to the skin and has restrained to repair the component effect, is particularly suitable for sensitive muscle or impaired skin.
2. According to the wrinkle-free repair cream provided by the application, the emulsifying capacity of natural surface active substances is improved by the compound emulsifying component, the cream with uniform emulsification, fine skin feel and high stability can be obtained, the permeability is good, the absorption is quicker, and the utilization rate of the repair active component can be improved.
3. The application provides a no line repair cream, the emulsification system that its was screened still has synergistic effect with the repair active ingredient, can show and promote skin elasticity degree, can obtain through sensory evaluation, the repair cream that this application provided, its infiltration effect of moisturizing is obvious, and there is not sensitization phenomenon, can effectively smooth fine lines after using, reduces dry line and wrinkle, slows down skin ageing, and effectively improves dry, lax phenomenon, makes skin moist smooth, is rich in elasticity.
Detailed Description
In order to more clearly explain the overall concept of the present application, the following detailed description is given by way of example. In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present application. It will be apparent, however, to one skilled in the art, that the present application may be practiced without one or more of these specific details. In other instances, well-known features of the art have not been described in order to avoid obscuring the present application.
Unless otherwise specified, the raw material grades in the following examples are all cosmetic grades and are all commercially available.
In the examples, oat β -dextran (CAS: 160872-27-5), hydrogenated lecithin (CAS: 92128-87-5), all provided by Guanao Biotech, Inc., Hubei, phytosterol provided by Siemens Fulvo Biotech, Inc., glycolipid provided by Chinesia chemical industries, Inc., Centella extract, CAS: 84696-21-9, Olea europaea extract, CAS: 84012-27-1, Shea butter, Nanjing Pongano Biotech, Inc., Portulaca extract, CAS: 90083-07-1, Heiyou extract, CAS: 84776-26-1, glycerin, 56-81-5, butylene glycol, CAS: 107-88-0, sodium hyaluronate, CAS: 9067-32-7, hydrolyzed collagen, CAS: 92113-31-0-58, and homogenizing machine provided by Guangzhou United emulsion Inc., a vacuum E-300, VME-300L, homogenizing machine.
The repair creams provided by the following examples are prepared by adopting the following method:
adding oligopeptide-1, oligopeptide-2, oat glucan, centella asiatica extract, purslane extract, black hibiscus cannabinus extract, antioxidant component, anti-allergy component, sodium hyaluronate, hydrolyzed collagen, glycolipid, propylene glycol and water into a water phase pot, stirring and mixing uniformly, and heating to 70-85 ℃ to obtain a water phase material; sequentially adding sanguis Draxonis, horse fat, radix Oenotherae Erythrosepalae seed extract, fructus Oleae Europaeae extract, shea butter, and hydrogenated lecithin into oil phase pan, heating to 70-85 deg.C, stirring, and mixing to obtain oil phase material; pumping the water phase material into emulsifying pot, stirring, homogenizing, pumping oil phase material and adding phytosterol, homogenizing at 70-85 deg.C, keeping the temperature for 60 min, adding citric acid, and adjusting pH to 5.8-6.5.
Embodiment 1 provides a non-wrinkle repair cream, which is prepared from the following raw materials in parts by weight: oligopeptide-11.5 parts, oligopeptide-21.2 parts, dragon's blood 5 parts, horse fat 7 parts, oat glucan 8 parts, centella extract 1.8 parts, evening primrose seed extract 1.1 parts, olive fruit extract 2 parts, shea butter 0.8 parts, purslane extract 1.5 parts, black Shengma root extract 2 parts, antioxidant component 6.8 parts (containing rosemary 2 parts, tea polyphenol 4 parts, tocotrienol 0.8 parts), anti-allergy component 2.5 parts (containing chamomile extract 0.8 parts, burdock root 1 parts, nobiletin 0.7 parts), xanthan gum 0.4 parts, glycerin 2 parts, propylene glycol 7 parts, sodium hyaluronate 1 part, hydrolyzed collagen 2 parts, hydrogenated lecithin 0.8 part, sucrose fatty acid ester 1.2 parts, and the balance of deionized water.
The component raw materials of the above example 1 are used as a matrix, and different surfactants and hydrogenated lecithin are compounded to be used as emulsifying components to obtain examples 1-15, so as to explore the emulsifying effect of the different compounded emulsifying components on the repair cream. An appropriate amount of the repair cream prepared in each example is taken and centrifuged at the rotating speed of 1000rpm for 5 minutes, whether oil-water separation exists in a centrifugal pipe or not is observed, and the selection and detection results of the emulsified components in each example are shown in table 1.
Table 1 emulsified components used in each example and centrifugation test results
Examples of the invention Emulsified component and weight portion Whether oil-water separation is performed
Example 1 0.8 part of hydrogenated lecithin, 1.2 parts of sucrose fatty acid ester Whether or not
Example 2 0.8 part of hydrogenated lecithin, 1.2 parts of rhamnolipid Whether or not
Example 3 0.8 part of hydrogenated lecithin, 1.2 parts of sophorolipid Whether or not
Example 4 0.8 part of hydrogenated lecithin and 1.2 parts of algal glycolipid Whether or not
Example 5 0.8 part of hydrogenated lecithin, 1.2 parts of phycoerythrin glycolipid Whether or not
Example 6 0.8 part of hydrogenated lecithin, 1.2 parts of ornithine ester Whether or not
Example 7 0.8 part of hydrogenated lecithin, 1.2 parts of cillipine ester Whether or not
Example 8 0.8 part of hydrogenated lecithin and 1.2 parts of phosphatidylethanolamine Whether or not
Example 9 0.8 part of hydrogenated lecithin and 1.2 parts of sodium surfactin Whether or not
Example 10 0.8 part of hydrogenated lecithin and 1.2 parts of tea saponin Whether or not
Example 11 0.8 part of hydrogenated lecithin, 1.2 parts of Tween 60 Is that
Example 12 0.8 part of hydrogenated lecithin, 1.2 parts of fatty alcohol sulfate Is that
Example 13 0.8 part of hydrogenated lecithin, 1.2 parts of fatty acid soap Is that
Example 14 0.8 part of hydrogenated lecithin, 1.2 parts of cetostearyl alcohol Is that
Example 15 0.8 part of hydrogenated lecithin and 1.2 parts of fatty alcohol-polyoxyethylene ether Is that
As can be seen from the data in table 1, the emulsification effect of the combination of hydrogenated lecithin with different surface active substances is different as a surface active substance of natural origin. Wherein, the emulsification effect can be improved by compounding glycolipid, cyclic lipopeptide, tea saponin and other biological surface active substances (examples 1-10) with hydrogenated lecithin, the prepared repair cream has good lifting property and certain spreadability, and the oil-water separation phenomenon does not occur after centrifugation; the use of conventional anionic, cationic or traditional nonionic emulsifiers (examples 11-15) combined with hydrogenated lecithin resulted in poor emulsification and oil-water separation after centrifugation.
The stability test was conducted for examples 1 to 10 in which oil-water separation did not occur by the above centrifugation. Wherein, the method for testing the stability is according to the QB/T1857-: and (3) standing at the temperature of 20 ℃ below zero and 40 ℃ for 60 days or carrying out cold and hot three-time circulation treatment, and observing whether an oil phase is separated out or not, wherein the cold and hot three-time circulation experiment is that the oil phase is alternately circulated at the temperature of 15 ℃ below zero to 48 ℃, and the interval of each temperature circulation is 24 hours. The emulsified components used in each example and the test results are shown in table 2.
Table 2 emulsifying components used in each example and stability test results
Figure BDA0002099859370000071
As can be seen from the data in Table 2, there is a difference in emulsion stability between the different emulsion components used in combination with hydrogenated lecithin at the same amount. Among them, the repair creams prepared in examples 4 to 6 showed better emulsion stability, and were observed to have very good lifting and spreading properties, and their sensory performance differences were not significant after the test.
Thus, examples 4 to 6 were hereinafter used as preferred examples to test the skin improvement effect, and the raw material composition of comparative example 2 was the same as in the examples except that conventional nonionic emulsifiers (0.8 parts of cetearyl alcohol and 1.2 parts of fatty alcohol polyoxyethylene ether) were used as the emulsifying component.
Examples 4-6 were tested for skin allergy by reference to the cosmetic hygiene code (2007 edition), as follows:
in each example, 4 white guinea pigs are selected for experiment, the laboratory temperature is 20-24 ℃, the relative humidity is 60-70%, the hairs on both sides of the spinal column of the experimental animal are cut off about 24 hours before the experiment, the hair removing range is 2cm × 3cm respectively, the smearing area is 2.5cm × 2.5.5 cm, the test object is taken to be about 0.5m L and smeared on the skin of one side, when the test object is prepared by using a non-irritant solvent, the solvent is smeared on the other side as a control and smeared for 1 time every day for 14 days continuously, the hairs are cut before each smearing, the residual test object is removed by using water or the non-irritant solvent, and the phenomena of erythema and edema are observed after one hour.
The skin elasticity test was carried out using the following experimental method:
30 volunteers with healthy skin and no allergic history are selected, and the male and the female are half in sex. The subjects washed their faces with the same mild cleanser before applying the samples, and the skin subjected to the elasticity test was the skin that had not been applied with any sample after cleaning the faces.
About 5 × 5cm is selected at the symmetrical position of the left and right sides of the face of the subject2The area of the size was used as an experimental area, and about 0.5g of the non-wrinkle cream obtained in example was applied to the left side of the face, and the same amount of the comparative example was applied to the right side of the face, and the application frequency was once every morning and night, and the cream was continuously applied every day.
Before the smear sample test, the elasticity of each test part where the cream was not started was measured using a skin elastic fiber texture tester manufactured by CK, Germany, and the elasticity was recorded as n0(ii) a After 1 week of continuous application, the same site was again subjected to the elasticity test and recorded as n1N is to be1And n0The ratio of (A) to (B) is expressed as elasticity rating indexThe skin elasticity increasing effect after one week of use is shown, and the larger the elasticity rating index is, the better the skin elasticity increasing effect of the sample is; then testing once a week for 6 weeks to obtain n1~n6And calculating the elasticity rating index of each time, wherein the data n of each test are repeated 5 times and averaged.
The results of the irritation evaluations and the elasticity rating index results for each example are shown in table 3.
TABLE 3 irritation evaluation and elasticity rating index results for each example
Figure BDA0002099859370000081
As can be seen from Table 3, no irritant reaction occurred in each experimental group; meanwhile, the skin elasticity measured in each example showed various degrees of increase after 6 weeks of continuous use of the cream, wherein the skin elasticity rating indexes of examples 4 to 6 were all higher than that of comparative example 2. The data show that compared with the repair cream using the existing emulsifier, the emulsified components of the repair cream in the embodiment have no irritation to skin, and the repair effect of the repair active component can be improved to play a certain synergistic effect.
However, the effect of improving the elasticity of the skin cream is not significantly different from that of the comparative example, and in order to further improve the repair effect of the repair cream, the components of example 6 are further optimized, and a component having an emulsifying effect is further added to the emulsified components, and the skin elasticity rating index is measured by the same method. The selection of specific emulsified components and their elasticity rating results are shown in table 4.
TABLE 4 selection of emulsified components and their elasticity rating results for each example
Figure BDA0002099859370000091
As can be seen from table 4, the synergistic effect degree difference of the different emulsified components added to the repair cream is larger, wherein the synergistic effect of the embodiment 13-20 added with the phytosterol is obviously better than that of the lanolin or cholesterol, especially the repair creams of the embodiments 17, 18 and 20 show a significant skin elasticity improving effect, can more effectively improve the repair effect of the repair active component, and have the effects of no wrinkles, anti-wrinkle and anti-aging.
Meanwhile, in the experiment, the condition that oil and water are separated is not caused when a proper amount of phytosterol is added into the repair cream, so that the addition of the phytosterol does not influence the emulsion stability of the repair cream.
The same screening of emulsified components as in the above experiment was performed for examples 4 and 5, and the results were the same as above, i.e., the synergistic effect of the addition of β -sitosterol, brassicasterol and avocado sterol was most pronounced.
Examples 17, 18 and 20 were subjected to sensory evaluation using the following method:
120 women between 35 and 55 years old were selected as subjects, and were asked to have healthy skin without history of allergy to skin disease, and were divided into 4 groups on average, 30 persons in each group, and aged 43. + -.2 years, and the use effects were observed and felt by wiping the face with the repair cream prepared in examples 17, 18, 20 and comparative example 2, respectively, and spot-painted uniformly. The application frequency is that the medicine is used once every morning and evening, the medicine is used for one month, the medicine is checked at least once every week to know whether systemic adverse reaction and local adverse reaction exist, each sensory evaluation index is scored in 1 month, the statistical score is averaged, one decimal is reserved, and the obtained result is shown in a table 5.
TABLE 5 sensory evaluation score
Figure BDA0002099859370000101
As can be seen from table 5, the sensory evaluation of the cream using the examples was significantly higher than the comparative examples. The repair cream provided by the embodiment has good permeability, is easy to absorb, has obvious moisturizing effect, can effectively smooth fine lines, reduce dry lines and wrinkles, slow down skin aging, effectively improve the phenomena of dryness and looseness, and enable the skin to be moist, smooth and elastic after being used. Meanwhile, no allergy phenomenon occurs in all the subjects, and the conditions of skin itch, stabbing pain, red swelling and the like do not occur, so that the anti-allergy score is higher. Therefore, the components of the non-wrinkle repair cream provided by the invention are natural and mild, and the non-wrinkle effect is more obvious compared with that of the traditional repair cream.
In conclusion, the wrinkle-free repair cream provided by the application is high in safety and nonirritant, avoids irritation of a traditional emulsifier to skin and inhibition of effects of repair components, and is particularly suitable for sensitive or damaged skin, the compound emulsified component used by the cream improves the emulsifying capacity of natural surface active substances, the cream is uniform in emulsification, fine and smooth in skin feel and high in stability, is good in permeability and rapid in absorption, can improve the utilization rate of the repair active components, has a synergistic effect with the repair active components, and can remarkably improve the skin elasticity, and particularly when 0.8 part of hydrogenated lecithin, 1.2 parts of sophorolipid and/or algal glycolipid and/or algal proteolipid, and 0.5 part of phytosterol (55% -95% of β -sitosterol and/or 5% -20% of rapeseed sterol and/or 25% -30% of avocado sterol) is used as the compound emulsified component, the repair effect of high in emulsification stability and capable of remarkably improving the skin elasticity can be achieved at the same time.
The above description is only an example of the present application and is not intended to limit the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.

Claims (8)

1. The wrinkle-free repair cream is characterized by comprising the following raw materials in parts by weight: 15-40 parts of a repairing active component; 18-35 parts of auxiliary effect component; 2-5 parts of an emulsifying component; the balance of deionized water;
the repairing active component comprises oligopeptide-1, oligopeptide-2, dragon's blood, horse fat, oat glucan, centella asiatica extract, evening primrose seed extract, olive fruit extract and shea butter; the auxiliary active components comprise purslane extract, black Shengma root extract, glycerol, propylene glycol, sodium hyaluronate and hydrolyzed collagen;
the antioxidant component is selected from one or more of tea polyphenol, grape extract, rosemary, lutein, vitamin A, vitamin C and tocotrienol; the anti-allergy component is one or more selected from chamomile extract, burdock root, aloe extract, glycyrrhizic acid and nobiletin; the thickening component is selected from one or more of carbomer, xanthan gum and hydrogenated castor oil;
the emulsifying component comprises 0.8-1 part of hydrogenated lecithin, 1.1-1.3 parts of glycolipid and 0.3-0.7 part of phytosterol, wherein the glycolipid is one or more selected from sophorolipid, algal glycolipid and phycoerythrin glycolipid, and the phytosterol comprises β -sitosterol, campesterol and avocado sterol.
2. The repair cream of claim 1, wherein the emulsifying component comprises 0.8 parts hydrogenated lecithin, 1.2 parts glycolipid, and 0.5 parts phytosterol.
3. The repair cream according to claim 2, characterized in that said glycolipid is selected from phycoerythrin glycolipids.
4. The repair cream of claim 1, wherein the phytosterols comprise β -sitosterol, campesterol and avocado sterol in an amount of 55%, 20% and 25% by mass, respectively.
5. The repair cream according to claim 1, characterized in that the repair active component comprises, in parts by weight: oligopeptide-10.5-2 parts, oligopeptide-20.8-1.5 parts, dragon's blood 3-6 parts, horse fat 5-8 parts, oat glucan 6-10 parts, centella asiatica extract 1.5-2 parts, evening primrose seed extract 0.8-1.2 parts, olive fruit extract 1.2-2.5 parts, and shea butter 3-5 parts; the auxiliary components comprise: 1-2.5 parts of purslane extract, 1-2.5 parts of black Shengma root extract, 6-10 parts of antioxidant component, 1.5-3 parts of anti-allergic component, 0.2-0.5 part of thickening component, 2-3 parts of glycerol, 5-8 parts of propylene glycol, 0.5-1 part of sodium hyaluronate and 1-3 parts of hydrolyzed collagen.
6. The repair cream according to claim 1, further comprising 0.5 to 1.5 parts of a pH adjuster.
7. The repair cream of claim 6, wherein the pH adjusting agent is citric acid.
8. Use of the wrinkle-free cream according to any one of claims 1 to 7 for improving skin elasticity, or for preparing an article for improving skin elasticity.
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