CN103315934A - Composition for promoting opening of skin aquaporin and preparation method thereof - Google Patents
Composition for promoting opening of skin aquaporin and preparation method thereof Download PDFInfo
- Publication number
- CN103315934A CN103315934A CN2013102482413A CN201310248241A CN103315934A CN 103315934 A CN103315934 A CN 103315934A CN 2013102482413 A CN2013102482413 A CN 2013102482413A CN 201310248241 A CN201310248241 A CN 201310248241A CN 103315934 A CN103315934 A CN 103315934A
- Authority
- CN
- China
- Prior art keywords
- skin
- minutes
- compositions
- mixed material
- aquaporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention particularly discloses a composition for promoting opening of skin aquaporin, which is mainly proportionally prepared from deionized water, glycerol, carbomer, xanthan gum, lycine, trehalose, inositol, taurine, lauryl mammary gland sodium lactate, monomethyl-monosilane triol, oxyproline, aspartic acid, yeast amino acid, polyglutamic acid, sodium hyaluronate, dipotassium glycyrrhetate, purslane extracting solution, licorice extract, ceramide, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary amine salt-14 and the like. The composition has the function of promoting opening of skin aquaporin, has better water replenishing and locking effect, and effectively prevents and resists the phenomena of dry skin mucosa and skin aging.
Description
Technical field
The present invention relates to promote the compositions of skin beauty water molecule transportation, particularly relate to the composition and method of making the same that promotes that the skin beauty water channel protein is opened.
Background technology
Horny layer is the top layer of skin, its hydration for skin appearance and physiology all tool be of great significance.The horny layer hydration determines by several factors, has material of moisturizing effect etc. such as ambient humidity, skin texture, Oil content and Protein content, barrier characteristics and some.Horn cell plays a decisive role to the reaction of these factors.
Aquaporin-3 (AQP3) be a kind of not only can the transport of water molecule but also can transport the difunctional aquaporin of the small-molecule substances such as glycerol.The transportation of the glycerol of AQP3 mediation is of great significance for the skin function tool in the skin keratin cell, and its functional defect can cause that xerosis cutis, flexibility decrease and barrier action weaken etc., and skin decreases.So the multiple action of AQP3 aspect skin function makes it become the potential target spot of skin related disease treatment and skin-protection product development etc.
During skin aging, it is dry that skin becomes.Therefore the gerontal patient, particularly in those 50 years old and above patient, with low sebum secretion, hormone change or the current by epidermis slow down relevant axersis or the common generation of dry mucous membranes.The skin pruritus and tight that can become, this is two kinds of characteristic symptoms of dry skin.Cause the example of the acquired disease of dry skin to comprise axersis and the eczema that photochemical treatment is induced.
The first replacement therapy that is used for dry skin is to use the topical product that is intended to recover skin barrier, can be in conjunction with the wetting agent of water as using, the example comprises carbamide and the lactic acid in the Proteolytic enzyme derivant composition that enters nature moisturizing factor NMF, silk polyprotein, be used for keeping the film forming agent of water, maybe can rebuild the material of skin barrier, such as Squalene, ceramide type, fatty acid.Yet these products have surface action, and it does not correct defective biology of the skin of suffering from chronic dehydration.
Because the characteristic of aquaporin, so aquaporin becomes be used to improving the skin hydration effect and reducing potential target spot biology of xerosis cutis sign.
Aquaporin-3(AQP3) regulator is keratinocyte at the cell of the most critical of epidermis internal control controlling the water circulation shunt volume, and they are just being organized below the cell of cuticular dead angle.The moisture Control of keratinocyte water channel albumen major effect cell, thus aquaporin-the 3rd learnt, the best aquaporin matter of skin moisture-keeping.In addition, AQP3 also participates in the circulation of control glycerol except the control current are logical, and this moment, it was called as water-glycerol channel albumen.AQP3 is one of AQP family member, is that first is found except water being had permeability, can also penetrating glycerol and the AQP of carbamide, so AQP3 also is the glycerol integrated protein at first.AQP3 is in expression and the function of skin: glycerol channel AQP3 great expression is in the horn cell of mammal skin epidermis.Mice, the main high expressed of AQP3 is in the keratinocyte basal layer of epidermis, and this confluent monolayer cells upwards is divided into cuticular layer, and forms the interface between cuticular layer and the skin corium.To studies show that of AQP3 knock-out mice skin function, though its epidermal structure without significant change, wettability and elasticity obviously descend, it is nearly 50% that the epidermis glycerol content reduces, obstacle all occurs in barrier function and injury repairing function.When or empty stomach glycerol injection oral to the AQP3 knock-out mice are corrected above-mentioned all skin function obstacles fully.Thus, reach a conclusion: glycerol is the factor of determination of horny layer water conservation and biological synthetic functional, and the barrier repair function of the glycerol function of motion of AQP3 after to the moisturizing of skin, elasticity and damage plays critical effect.AQP3 this pivotal role in epidermis physiology can be used for developing in the dermopathic new therapy of cosmetics and the change of skin beauty water content.Aquaporin plays a significant role in keeping body water balance and homeostasis.
But the transmission of the water of skin layer is limited upward from darker skin layer for the product of prior art.The transmission of water and glycerol must be undertaken by cell membrane, and aquaporin namely is responsible for this process.Be positioned at limited amount and different and different according to skin type and skin area of the aquaporin of Skin Cell film.The effect that traditional product obtains in most cases is the short time, because usually can not obtain the deep layer effect, and namely can moistening darker skin layer.Therefore, prior art lack can promote or the positive impact horny layer from the product of the kind hydration of structural reform.
Summary of the invention
The objective of the invention is to provide the compositions of a kind of short effectively promotion, the unlatching of chafe aquaporin, thereby further make human body skin obtain deeper moistening.
According to an aspect of the present invention, provide a kind of compositions that promotes that the skin beauty water channel protein is opened, comprise by weight ratio following component:
In some embodiments, promote the compositions that the skin beauty water channel protein is opened, preferably, comprise by weight ratio following component:
Another object of the present invention is to provide a kind of method for preparing above-mentioned composition.Namely promote the preparation method of the compositions that the skin beauty water channel protein is opened may further comprise the steps:
(1) by each raw material components of weight portion proportioning difference weighing of claim 1 or 2, places separately;
(2) with deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in the step (1), add the interior mixing of reactor and be heated to 80～85 ℃, stirred 20～30 minutes, then evacuation, and being cooled to 75～80 ℃, constant temperature is 25～35 minutes again;
(3) mixed material in the step (2) is cooled to 36～45 ℃ of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, taurine in the step (1), stirred the mixture 15～25 minutes;
(4) lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that adds successively in the step (1) falls in the mixed material in the step (3), mixes material 15～25 minutes;
(5) mixed material in the step (4) is kept 30～35 ℃ constant temperature 10～15 minutes, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in the step (1), then stirred 30～35 minutes, vacuum froth breaking, then discharging.
The present invention compared with prior art, its beneficial effect is: compositions of the present invention has the function that promotes that the skin beauty water channel protein is opened, skin is had profound moisturizing moisten function, namely have stronger moisturizing and lock water effect, can also effectively prevent and resist mucocutaneous drying and skin ageing phenomenon simultaneously.
Trehalose is the sugar that repeatedly stress generate in the dehydration at yeast, can help cell to preserve precious moisture under xerodermatic condition.Carbamide is to keep the indispensable nature moisturizing factor composition of skin moisture, and can come off by the accelerated ageing cutin.Betanin, inosite, taurine can be regulated moisture flowing in cell, and especially taurine has the ability of composing skin cell alive, and can provide energy supplement to skin fast.Yeast amino acid can promote the unlatching of aquaporin-3.Polyglutamic acid has good moisture-retaining capacity.Ceramide can prevent that moisture from distributing, effectively protection and skin care.Each constituent in the compositions of the present invention all can be by commercial acquisition, and jointly cooperate by a certain percentage, mutually coordinate, can promote the unlatching of skin beauty water channel protein, thereby so that active moisturizing composition rapid permeability is absorbed by Skin Cell to skin, improve moistening effect.
The specific embodiment
Embodiment 1
The present invention promotes the compositions that the skin beauty water channel protein is opened, and comprise by weight ratio following component: deionized water is 53.17 parts; glycerol is 3.50 parts; carbomer is 0.02 part; xanthan gum is 0.01 part; EDETATE SODIUM is 0.02 part; allantoin is 0.05 part; carbamide is 1.00 parts; vitamin B5 is 0.20 part; betanin is 0.20 part; trehalose is 0.50 part; inosite is 0.50 part; taurine is 0.50 part; lauryl mammary gland sodium lactate is 0.20 part; the monomethyl silantriol is 1.00 parts; hydroxyproline is 1.00 parts; aspartic acid is 1.00 parts; yeast amino acid is 0.50 part; polyglutamic acid is 0.01 part; hyaluronate sodium is 0.01 part; glycyrrhizic acid dipotassium is 0.01 part; Herba Portulacae extract is 1.50 parts; Radix Glycyrrhizae extract is 1.30 parts; ceramide 3 is 0.001 part; Cer AP is 0.001 part; Cer EOS is 0.001 part; phytosphingosine is 0.05 part; cholesterol is 0.10 part; oligopeptide-1 is 0.001 part; polyquaternary ammonium salt-14 is 0.05 part.(above raw material is commercially available)
Concrete preparation method and step are as follows:
(1) by said components and respectively each raw material components of weighing, the separately placement of weight portion proportioning;
(2) with deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in the step (1), add to mix also in the reactor and be heated to 80 ℃, stirred 20 minutes, evacuation then, and be cooled to 75 ℃, constant temperature is 25 minutes again;
(3) mixed material in the step (2) is cooled to 36 ℃ of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, taurine in the step (1), stirred the mixture 15 minutes and constant temperature 15 minutes;
(4) lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that adds successively in the step (1) falls in the mixed material in the step (3), mixes material 15 minutes;
(5) mixed material in the step (4) is kept 30 ℃ constant temperature 10 minutes, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in the step (1), then stirred 30 minutes, vacuum froth breaking, then discharging.
Embodiment 2
The present invention promotes the compositions that the skin beauty water channel protein is opened, and comprise by weight ratio following component: deionized water is 76.67 parts; glycerol is 4.50 parts; carbomer is 0.04 part; xanthan gum is 0.04 part; EDETATE SODIUM is 0.10 part; allantoin is 0.20 part; carbamide is 5.00 parts; vitamin B5 is 1.00 parts; betanin is 2.00 parts; trehalose is 2.00 parts; inosite is 1.50 parts; taurine is 1.00 parts; lauryl mammary gland sodium lactate is 0.40 part; the monomethyl silantriol is 2.00 parts; hydroxyproline is 3.00 parts; aspartic acid is 2.00 parts; yeast amino acid is 4.00 parts; polyglutamic acid is 0.10 part; hyaluronate sodium is 0.10 part; glycyrrhizic acid dipotassium is 0.40 part; Herba Portulacae extract is 5.50 parts; Radix Glycyrrhizae extract is 2.30 parts; ceramide 3 is 0.01 part; Cer AP is 0.02 part; Cer EOS is 0.02 part; phytosphingosine is 0.12 part; cholesterol is 0.30 part; oligopeptide-1 is 0.08 part; polyquaternary ammonium salt-14 is 0.10 part.
Concrete preparation method and step are as follows:
(1) by said components and respectively each raw material components of weighing, the separately placement of weight portion proportioning;
(2) with deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in the step (1), add to mix also in the reactor and be heated to 85 ℃, stirred 30 minutes, evacuation then, and be cooled to 80 ℃, constant temperature is 35 minutes again;
(3) mixed material in the step (2) is cooled to 45 ℃ of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, taurine in the step (1), stirred the mixture 25 minutes and constant temperature 20 minutes;
(4) lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that adds successively in the step (1) falls in the mixed material in the step (3), mixes material 25 minutes;
(5) mixed material in the step (4) is kept 35 ℃ constant temperature 15 minutes, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in the step (1), then stirred 35 minutes, vacuum froth breaking, then discharging.
Embodiment 3
The present invention promotes the compositions that the skin beauty water channel protein is opened, and comprise by weight ratio following component: deionized water is 60 parts; glycerol is 4.00 parts; carbomer is 0.03 part; xanthan gum is 0.03 part; EDETATE SODIUM is 0.05 part; allantoin is 0.10 part; carbamide is 2.00 parts; vitamin B5 is 0.50 part; betanin is 1.00 parts; trehalose is 1.00 parts; inosite is 0.80 part; taurine is 0.80 part; lauryl mammary gland sodium lactate is 0.30 part; the monomethyl silantriol is 1.50 parts; hydroxyproline is 1.50 parts; aspartic acid is 1.50 parts; yeast amino acid is 2.50 parts; polyglutamic acid is 0.05 part; hyaluronate sodium is 0.05 part; glycyrrhizic acid dipotassium is 0.10 part; Herba Portulacae extract is 2.50 parts; Radix Glycyrrhizae extract is 1.50 parts; ceramide 3 is 0.008 part; Cer AP is 0.008 part; Cer EOS is 0.008 part; phytosphingosine is 0.08 part; cholesterol is 0.20 part; oligopeptide-1 is 0.03 part; polyquaternary ammonium salt-14 is 0.08 part.
Concrete preparation method and step are as follows:
(1) by said components and respectively each raw material components of weighing, the separately placement of weight portion proportioning;
(2) with deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in the step (1), add to mix also in the reactor and be heated to 83 ℃, stirred 27 minutes, evacuation then, and be cooled to 78 ℃, constant temperature is 30 minutes again;
(3) mixed material in the step (2) is cooled to 40 ℃ of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, taurine in the step (1), stirred the mixture 20 minutes and constant temperature 18 minutes;
(4) lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that adds successively in the step (1) falls in the mixed material in the step (3), mixes material 20 minutes;
(5) mixed material in the step (4) is kept 32 ℃ constant temperature 13 minutes, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in the step (1), then stirred 33 minutes, vacuum froth breaking, then discharging.
The effect experiment of the present composition
The compositions of (one) getting the embodiment of the invention 3 is carried out effect mensuration, and concrete assay method and measurement result are specific as follows:
Take the compositions that obtains according to embodiment 3 production as example, and adopt matched group (this matched group be two groups, wherein the product that uses of matched group one is normal saline, the product that matched group two uses is glycerol) carry out the actual use of crowd tracking test, with the result of use of the elimination eczema of investigating compositions of the present invention.In this experiment, choose 300 volunteers, 50～60 years old age, eczema is in various degree arranged respectively on the arm, the volunteer is divided into three groups of (experimental group, matched group one and matched group two) every group of 100 people at random, experimental group is coated with to be used compositions of the present invention, matched group one to be coated with to use normal saline, and matched group two is coated with uses glycerol.Every day, sooner or later each once improved the evaluation result record of effect to eczema as shown in table 1 after 45 days.
Table 1-eczema is improved the evaluation result of effect
The structure that records from table 1 as can be known, compositions of the present invention has better therapeutic effect to the acquired disease-eczema of dry skin.Wherein produce effects refers to that compositions of the present invention can cure eczema, refers to that effectively compositions of the present invention has the effect of alleviating to the eczema degree.
(2) prove the impact that compositions of the present invention is expressed the aquaporin 3 in the skin samples, get the combination of embodiment 3 and measure, concrete assay method and result are as follows:
Cultivate the application on human skin sample at the gas/liquid interface.Experimental group is the application on human skin sample of the compositions of local application embodiment 3, and matched group one is untreated application on human skin sample, and matched group two is the application on human skin sample of local application glycerol.All samples was all hatched 48 hours.Then after fixing these skin samples with formaldehyde, be embedded in afterwards in the paraffin, then obtain 4～5 microns section.In a plurality of washings with carry out immune labeled after hatching the step of these sections.By aquaporin 3 specific antibodies, then be coupling agent fluorescently-labeled two anti-carry out immune labeled, then use Epi-fluorescence microscope (Nikon Eclipse E600 microscope) to check described skin biopsy, its epidermis is as shown in table 2 than upper strata fluorescent effect grade.
Table 2-epidermis is than upper strata fluorescent effect grade
| ? | Experimental group | Matched group one | Matched group two |
| Fluorescent effect | By force | Generally | Generally |
As shown in Table 2, the compositions of experimental group promotes the expression of aquaporin 3 strongly, particularly shows peridermal expression.
(3) test of the moisture behind the human body use present composition, concrete method of testing and result are as follows:
Take the compositions of embodiment 3 as example, and adopt matched group to carry out the actual use of crowd tracking test, matched group does not carry out any moisturizing processing.In this experiment, choose 30 volunteers, the concrete age is determined at random.Volunteer's left hand arm position is coated with uses compositions of the present invention, and right arm does not use any product to process as the blank group.Begin to measure with the cutin drimeter water content base value of Experimental Area in experiment, the experiment beginning is after 20 minutes, 5 hours, 10 hours and 24 hours, measure respectively again the moisture content of skin 5 times of different time sections with identical gauge, average, the statistics volunteer tests the numerical value that the position records at every turn, the moisture increment of analyzing skin.
The moisture increment of table 3-skin
| ? | 20 minutes | 5 hours | 10 hours | 24 hours |
| The moisture increment of experimental group | 40% | 36% | 29% | 23% |
| The moisture increment of matched group | 1.2% | 6% | 4% | 2.2% |
As known from Table 3, compositions of the present invention can keep the skin wet to skin at short notice quickly, and the lock water function is better, can allow skin realize the long-acting moisturizing of whole day.
Above-described only is some embodiments of the present invention.For the person of ordinary skill of the art, under the prerequisite that does not break away from the invention design, can also make some distortion and improvement, these all belong to the protection domain of invention.
Claims (3)
1. promote the compositions that the skin beauty water channel protein is opened, it is characterized in that, comprise by weight ratio following component:
2. the compositions of promotion skin beauty water channel protein unlatching according to claim 1 is characterized in that, comprises by weight ratio following component:
3. the preparation method of the compositions of claim 1 or 2 described promotion skin beauty water channel proteins unlatchings is characterized in that, may further comprise the steps:
(1) by each raw material components of weight portion proportioning difference weighing of claim 1 or 2, places separately;
(2) with deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in the step (1), add the interior mixing of reactor and be heated to 80～85 ℃, stirred 20～30 minutes, then evacuation, and being cooled to 75～80 ℃, constant temperature is 25～35 minutes again;
(3) mixed material in the step (2) is cooled to 36～45 ℃ of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, taurine in the step (1), stirred the mixture 15～25 minutes;
(4) add successively lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, polyglutamic acid in the step (1) in the mixed material in the step (3), mixed material 15～25 minutes;
(5) mixed material in the step (4) is kept 30～35 ℃ constant temperature 10～15 minutes, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in the step (1), then stirred 30～35 minutes and carry out the vacuum froth breaking.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310248241.3A CN103315934B (en) | 2013-06-21 | 2013-06-21 | Composition for promoting opening of skin aquaporin and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310248241.3A CN103315934B (en) | 2013-06-21 | 2013-06-21 | Composition for promoting opening of skin aquaporin and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103315934A true CN103315934A (en) | 2013-09-25 |
| CN103315934B CN103315934B (en) | 2014-07-09 |
Family
ID=49185173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310248241.3A Active CN103315934B (en) | 2013-06-21 | 2013-06-21 | Composition for promoting opening of skin aquaporin and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103315934B (en) |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103462881A (en) * | 2013-10-10 | 2013-12-25 | 深圳市金因生物技术有限公司 | Composite capable of promoting skin micro-ecological balance and preparation method thereof |
| CN103520081A (en) * | 2013-09-27 | 2014-01-22 | 无限极（中国）有限公司 | External skin care product capable of adjusting skin immunity and delaying skin aging |
| CN103655224A (en) * | 2013-11-14 | 2014-03-26 | 陕西东大生化科技有限责任公司 | Preparation with function of preventing and treating sensitivity or allergy and application thereof |
| CN104173207A (en) * | 2014-08-11 | 2014-12-03 | 上海贝泰妮生物科技有限公司 | Skin barrier repairing preparation and preparation method thereof |
| CN104643073A (en) * | 2015-02-10 | 2015-05-27 | 深圳市金因生物技术有限公司 | Composition for regulating sub-health status of crowd suffering from lipodystrophy |
| CN104814881A (en) * | 2015-05-07 | 2015-08-05 | 广州市花安堂生物科技有限公司 | Moisturizing and repairing composition and epidermis biomimetic membrane liquid crystal complex constructed therefrom |
| CN104940047A (en) * | 2015-06-25 | 2015-09-30 | 广州保税区雅兰国际化妆品有限公司 | Cosmetic composition with moisturizing function and preparation method thereof |
| CN105193655A (en) * | 2015-09-25 | 2015-12-30 | 斐丝肌(上海)商贸有限公司 | Composite with efficacies of water locking and moisturizing, face mask and face mask preparation method |
| CN105213252A (en) * | 2015-09-25 | 2016-01-06 | 斐丝肌(上海)商贸有限公司 | A kind ofly lock essence of water moisture-keeping efficacy and preparation method thereof |
| CN105456057A (en) * | 2015-12-31 | 2016-04-06 | 广州市科能化妆品科研有限公司 | Moisture locking and moisturizing composition with mousse texture |
| CN105853302A (en) * | 2016-05-30 | 2016-08-17 | 李建东 | Deep hydrating mask liquid and preparation method thereof |
| CN106963660A (en) * | 2017-04-06 | 2017-07-21 | 湖南御家化妆品制造有限公司 | A kind of skin repair moisture-keeping composition and its application in cosmetics are prepared |
| CN107397709A (en) * | 2017-07-31 | 2017-11-28 | 上海中翊日化有限公司 | A kind of composition and personal care articles containing yeast extract |
| CN108619007A (en) * | 2018-06-29 | 2018-10-09 | 广西浙缘农业科技有限公司 | A kind of face cream containing camellia seed oil |
| CN108653140A (en) * | 2018-06-28 | 2018-10-16 | 广西浙缘农业科技有限公司 | A kind of camellia seed oil cosmetic composition and preparation method thereof |
| CN111297725A (en) * | 2018-12-11 | 2020-06-19 | 安琪酵母股份有限公司 | Skin care composition for restoring skin barrier function and preparation method and application thereof |
| CN111419751A (en) * | 2020-04-23 | 2020-07-17 | 广州市科能化妆品科研有限公司 | Soothing composition, preparation method thereof and skin care product containing soothing composition |
| JP2021004186A (en) * | 2019-06-25 | 2021-01-14 | 小林製薬株式会社 | External composition |
| CN114886811A (en) * | 2022-05-25 | 2022-08-12 | 广州澳莱娜生物科技有限公司 | Composition for repairing sensitive skin |
| EP4356898A1 (en) * | 2022-10-20 | 2024-04-24 | Croda Korea Limited | Cosmetic composition comprising ceramides and sphingolipid |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010119191A1 (en) * | 2009-04-15 | 2010-10-21 | Isp Investments Inc. | Cosmetic and/or pharmaceutical composition comprising a peptidic hydrolysate that can reinforce the barrier function |
| CN102357070A (en) * | 2011-11-10 | 2012-02-22 | 深圳市金因生物技术有限公司 | Hydrolyzed silk protein/ recombinant human Epidermal Growth Factor (rhEGF) compound skin care facial mask and preparation method thereof |
| CN102579297A (en) * | 2012-03-16 | 2012-07-18 | 深圳市金因生物技术有限公司 | Cosmetic for improving tolerance of skin and preparation method thereof |
-
2013
- 2013-06-21 CN CN201310248241.3A patent/CN103315934B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010119191A1 (en) * | 2009-04-15 | 2010-10-21 | Isp Investments Inc. | Cosmetic and/or pharmaceutical composition comprising a peptidic hydrolysate that can reinforce the barrier function |
| CN102357070A (en) * | 2011-11-10 | 2012-02-22 | 深圳市金因生物技术有限公司 | Hydrolyzed silk protein/ recombinant human Epidermal Growth Factor (rhEGF) compound skin care facial mask and preparation method thereof |
| CN102579297A (en) * | 2012-03-16 | 2012-07-18 | 深圳市金因生物技术有限公司 | Cosmetic for improving tolerance of skin and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 邓舜扬,何丽梅主编: "《精细化工配方集锦》", 31 March 2000, 化学工业出版社 * |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520081A (en) * | 2013-09-27 | 2014-01-22 | 无限极（中国）有限公司 | External skin care product capable of adjusting skin immunity and delaying skin aging |
| CN103520081B (en) * | 2013-09-27 | 2015-10-28 | 无限极（中国）有限公司 | The external use skin care of a kind of regulation of skin immunity, delay skin aging |
| CN103462881B (en) * | 2013-10-10 | 2016-06-22 | 深圳市容大生物技术有限公司 | A kind of composition and method of making the same promoting skin microecological balance |
| CN103462881A (en) * | 2013-10-10 | 2013-12-25 | 深圳市金因生物技术有限公司 | Composite capable of promoting skin micro-ecological balance and preparation method thereof |
| CN103655224A (en) * | 2013-11-14 | 2014-03-26 | 陕西东大生化科技有限责任公司 | Preparation with function of preventing and treating sensitivity or allergy and application thereof |
| CN104173207A (en) * | 2014-08-11 | 2014-12-03 | 上海贝泰妮生物科技有限公司 | Skin barrier repairing preparation and preparation method thereof |
| CN104173207B (en) * | 2014-08-11 | 2016-08-31 | 上海贝泰妮生物科技有限公司 | A kind of skin barrier preparation for repairing and preparation method thereof |
| CN104643073A (en) * | 2015-02-10 | 2015-05-27 | 深圳市金因生物技术有限公司 | Composition for regulating sub-health status of crowd suffering from lipodystrophy |
| CN104814881A (en) * | 2015-05-07 | 2015-08-05 | 广州市花安堂生物科技有限公司 | Moisturizing and repairing composition and epidermis biomimetic membrane liquid crystal complex constructed therefrom |
| CN104940047A (en) * | 2015-06-25 | 2015-09-30 | 广州保税区雅兰国际化妆品有限公司 | Cosmetic composition with moisturizing function and preparation method thereof |
| CN104940047B (en) * | 2015-06-25 | 2017-12-01 | 广州保税区雅兰国际化妆品有限公司 | A kind of cosmetic composition of replenishing water and preserving moisture and preparation method thereof |
| CN105213252A (en) * | 2015-09-25 | 2016-01-06 | 斐丝肌(上海)商贸有限公司 | A kind ofly lock essence of water moisture-keeping efficacy and preparation method thereof |
| CN105193655A (en) * | 2015-09-25 | 2015-12-30 | 斐丝肌(上海)商贸有限公司 | Composite with efficacies of water locking and moisturizing, face mask and face mask preparation method |
| CN105456057A (en) * | 2015-12-31 | 2016-04-06 | 广州市科能化妆品科研有限公司 | Moisture locking and moisturizing composition with mousse texture |
| CN105456057B (en) * | 2015-12-31 | 2020-02-21 | 广州市科能化妆品科研有限公司 | Water-locking and moisturizing composition with mousse texture |
| CN105853302A (en) * | 2016-05-30 | 2016-08-17 | 李建东 | Deep hydrating mask liquid and preparation method thereof |
| CN106963660A (en) * | 2017-04-06 | 2017-07-21 | 湖南御家化妆品制造有限公司 | A kind of skin repair moisture-keeping composition and its application in cosmetics are prepared |
| CN107397709A (en) * | 2017-07-31 | 2017-11-28 | 上海中翊日化有限公司 | A kind of composition and personal care articles containing yeast extract |
| CN108653140A (en) * | 2018-06-28 | 2018-10-16 | 广西浙缘农业科技有限公司 | A kind of camellia seed oil cosmetic composition and preparation method thereof |
| CN108619007A (en) * | 2018-06-29 | 2018-10-09 | 广西浙缘农业科技有限公司 | A kind of face cream containing camellia seed oil |
| CN111297725A (en) * | 2018-12-11 | 2020-06-19 | 安琪酵母股份有限公司 | Skin care composition for restoring skin barrier function and preparation method and application thereof |
| JP2021004186A (en) * | 2019-06-25 | 2021-01-14 | 小林製薬株式会社 | External composition |
| JP7356826B2 (en) | 2019-06-25 | 2023-10-05 | 小林製薬株式会社 | External composition |
| CN111419751A (en) * | 2020-04-23 | 2020-07-17 | 广州市科能化妆品科研有限公司 | Soothing composition, preparation method thereof and skin care product containing soothing composition |
| CN114886811A (en) * | 2022-05-25 | 2022-08-12 | 广州澳莱娜生物科技有限公司 | Composition for repairing sensitive skin |
| EP4356898A1 (en) * | 2022-10-20 | 2024-04-24 | Croda Korea Limited | Cosmetic composition comprising ceramides and sphingolipid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103315934B (en) | 2014-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103315934B (en) | Composition for promoting opening of skin aquaporin and preparation method thereof | |
| CN102302424B (en) | Anti-wrinkle agent | |
| CN107854355A (en) | A kind of anti-apolexis composition and its preparation method and application | |
| CN105030564A (en) | Composition with long-lasting moisturizing function and application of composition | |
| CN107595650A (en) | A kind of cosmetic composition that can promote Transdermal absorption containing sponge micropin | |
| CN107049903A (en) | A kind of cream for being used for sensitive skin and preparation method thereof | |
| CN106456478A (en) | Cosmetic and pharmaceutical applications of gallic acid and gallic acid derivatives | |
| CN108836905A (en) | The moisturizing maintenance composition for stimulating cell aquaporin to generate | |
| CN101146508A (en) | Cosmetic and cosmeceutical compositions for restoration of skin barrier function | |
| CN108430587A (en) | Include the personal care composition of taurine, arginine, glycine | |
| CN109674686A (en) | A kind of composition and preparation method thereof of maintenance damaged skin | |
| CN111067840A (en) | Polypeptide whitening and repairing wash-free mask | |
| CN106377488A (en) | Skin care substrate with moisture retaining and oil controlling effects and preparation method and application thereof | |
| CN106038377A (en) | Multi-efficacy moisturizer | |
| CN110013447A (en) | A kind of cream and preparation method thereof for dispelling striae of pregnancy | |
| CN104254318A (en) | Cosmetic composition containing the slime of snails fed with red ginseng and method for manufacturing same | |
| CN114588061A (en) | Anti-aging and wrinkle-removing composition, preparation method thereof and skin care product | |
| TWI766379B (en) | Composition, application thereof in preparation of skin product for overnight person skin caring, and skin care product for overnight person skin | |
| CN106109391A (en) | A kind of potent moisture retention water and preparation method thereof | |
| CN111358748B (en) | Mask essence containing date palm seed extract and preparation method thereof | |
| CN107648066A (en) | A kind of anti-aging skin-active shin moisturizer containing growth factor and preparation method thereof | |
| CN111265454A (en) | Moisture-preserving and water-replenishing anti-aging cosmetic composition | |
| CN110638696A (en) | Composition for repairing skin barrier and preparation method and application thereof | |
| CN109394595A (en) | Facial mask essence with deep water supplement and barrier reparation | |
| CN112807271B (en) | Moisturizing composition, essence and preparation method of moisturizing composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 518000 10a, B and C, building 8, qiaochengfang, No. 4080, Qiaoxiang Road, Gaofa community, Shahe street, Nanshan District, Shenzhen, Guangdong Patentee after: Shenzhen Rongda Biotechnology Co.,Ltd. Address before: No.7, Keji Zhongyi Road, Nanshan District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN GENE BIOLOGICAL TECHNOLOGY Co.,Ltd. |
|
| CP03 | Change of name, title or address |