CN102579297A - Cosmetic for improving tolerance of skin and preparation method thereof - Google Patents
Cosmetic for improving tolerance of skin and preparation method thereof Download PDFInfo
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- CN102579297A CN102579297A CN2012100696131A CN201210069613A CN102579297A CN 102579297 A CN102579297 A CN 102579297A CN 2012100696131 A CN2012100696131 A CN 2012100696131A CN 201210069613 A CN201210069613 A CN 201210069613A CN 102579297 A CN102579297 A CN 102579297A
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Abstract
The invention discloses a cosmetic for improving tolerance of skin and a preparation method thereof. The cosmetic includes, by weight, 0.002% to 0.01% of oligopeptide-1, 1% to 10% of rhodophyta extract, 3% to 4.5% of 1, 2-pentylene glycol, 0.1% to 1% of rice amino acid, 0.1% to 5% of purslane extract, 0.01% to 0.1% of ceramide 3, 0.01% to 0.1% of ceramide 6, 0.01% to 0.1% of ceramide 1, 0.01% to 0.2% of phytosphingosine, 0.1% to 1% of cholesterol, 0.5% to 2% of sodium lauroyl lactylate, 1% to 5% of cestrum nocturnum, and the balance deionized water. The invention further provides a preparation method of the cosmetic. The cosmetic for improving the tolerance of skin and the preparation method thereof have the advantages of being simple in preparation method without unpleasant smell of Chinese medicine, good in stability, and helpful to improve the tolerance of the skin after a period of usage. The activation threshold value of dendritic cells of the skin is adjusted after long term usage, and the anti-stimulation capacity of the skin to the outside is improved.
Description
Technical field
The present invention relates to skin protection cosmetics, particularly improve cosmetics of skin tolerance and preparation method thereof.
Background technology
Responsive skin symptom is meant that people's skin receives that external environment influence back produces twinge, itches, uncomfortable feeling such as scorching hot, dry, tight, erythema, swelling occur, perhaps other the macroscopic skin symptoms of breaking.
In the sensitivity investigation that we do Chinese Consumer's, show: tender subject is perplexing near the Chinese about half, when wherein the tender subject of 70% consumer occurs in season alternation.External investigation also is similar.
Aspect formula development, cosmetics company can select gentle more raw material usually for use, especially impurities in raw materials is had clear and definite requirement.In prescription, will consider the purification of raw materials such as adding similar α-bisabolol, glycyrrhizic acid dipotassium, synthetic or plant extraction liquid simultaneously; Mainly from suppressing NO, TNF-α, PGE2, interleukin, leukotriene and histamine equal angles, the active ingredient of these interpolations can suppress generation hypersensitive.But; For sensitive-skinned people; Be not enough only, but need the startup threshold value of adjustment skin BMDC, improved skin irritation ability to external world through exogenous more additional inhibition cytokines; Improve the tolerance of skin, guarantee that skin obtains necessary skin nursing some functional raw materials; This before be unthinkable.
BMDC is outpost's type cell of the balance refractory state and the state of alert.When skin is under attack, it will give the alarm.If there is not this reaction, can't start the significant reaction of skin.The uncomfortable of allergic skin feels to have part possibly come from BMDC " extent of reaction ".When receiving warning signal, when perhaps the startup threshold value of tolerance was low, the sensory reaction of skin will be started immediately.And the lower startup threshold value of skin will cause skin overreaction to occur.Therefore, the extent of reaction of adjustment BMDC, when under attack, cell can be made the most appropriate reaction, just can avoid occurring uncomfortable sensation.
Summary of the invention
The purpose of this invention is to provide a kind of cosmetics that improve the skin tolerance and preparation method thereof.(dendritic cells is that (antigen presenting cells APC), has unique function to inducing primary immune response to the strongest full-time antigen-presenting cell of finding so far of function DC) to BMDC.To antigenic picked-up, processing, handle and present in the process, DC has the general character of general APC, also shows simultaneously some distinctive biological characteristicses.The angtigen presentation effect of DC obviously is better than macrophage, and it can follow classical histocompatibility antigen (MHC) 1 classpath and carry
Be exogenous antigen, and the activating cytotoxic T cell (Cytotoxie T lymphoeyte CTL), is bringing into play crucial effect aspect antiviral and the tumour immunity.
The final result of the maturity state decision immunne response of DC.The differentiation and development of DC mainly experiences four-stage: hematopoietic stem cell, DC precursor, immature DC (immature DC, iDC), ripe DC (mature DC, mDC).IDC plays a part immune surveillance just as intravital " soldier ", and it is distributed in nearly all tissue and organ, has powerful endocytosis, migrates to local secondary lymphoid tissue from peripheral tissues's antigen constantly, but its angtigen presentation hypofunction.When inflammation and tissue injury appear in peripheral tissues; Ripe signal (bacteria dna, double stranded RNA, LPS, pro-inflammatory cytokine and derive from the signal CD40L etc. of T cell) can induce the iDC of antigen ripe gradually in migrating to adenoid process; Make it arrive to become after regional nodes and have the mDC that strong antigen is offered function; Its collaborative stimulation molecule and HLA II quasi-molecule high expressed, induce immune response.Under the normal physiological state that does not have the damage of infection and inorganization; The iDC that is present in peripheral tissues constantly absorbs the protein (like the protein in respiratory tract and the digestive tract) in autoantigen and the non-infection environment; Get into draining lymph node; Quilt not sensitized T cell is removed and is induced the formation of regulating the T cell, induces peripheral tolerance.This mechanism makes " danger signal " when inflammation and tissue injury discerned and defendd to the immune system of body can better, and autoantigen and harmless exogenous antigen are kept tolerance.
DC can induce the formation of CD4+ and CD8+ regulatory T cells; Thereby the propagation of the T cell of inhibition antigen-specific and the secretion of Th1 cytokines; Make under physiological status autoantigen and harmless exogenous antigen are formed tolerance, under pathological state, participate in the adjusting that immune convulsion is answered.
Inducing immune tolerance or immunoregulatory DC subgroup.DC is the heterogeneous cell colony of a group; Different DC subgroup immunity-regulatings are replied trend; People's DC can be divided into the DC (DC1 of cells of monocytic origin;) subgroup and plasma cell appearance DC (DC2) subgroup, induce Th0 to Th1 and Th2 differentiation respectively, wherein Th1 and Th2 are unbalance is the pathogenic of a lot of diseases (like autoimmune disease) or increases the weight of one of key factor.Toleration or the modulability DC subgroup major function found at present are: through self secreting the propagation of IL one 10 inhibition T cells with antigenic specificity; Induce CD4+, CD25+ regulatory T cells (Tr) and the differentiation of CD8+ suppressor T lymphocyte; Misra etc. have studied people's CD4+, the CD25+Tr influence to DC maturation and function; Find that Tr can make DC secretion IL 1 increase and costimulatory molecules expression reduction, the function of forfeiture APC, thus suppress immunne response.
DC2 can suppress the generation that the Th1 type is replied through inducing the reaction of Th2 type; The 1L-1O that the reaction of Th2 type produces can influence the maturation of DC; Reduce its MHC II and divide the expression of giving, working in coordination with stimulation molecule and adhesion molecule, and can induce the differentiation of regulatory T cells, thereby produce immunologic tolerance.Discover that further the activated DC2 of CD40L can also induce CD8+T emiocytosis IL-1O.Maturation through influencing DC is brought into play inhibitory action; This inhibitory action can be by the 1L-10 antibody blocking; So it is different with the mechanism of action of CD8+ regulatory T cells; Latter's inhibition CD83+T cell shows self low propagation and low cytotoxicity when accepting antigenic stimulus once more, and can suppress the reactivity of unsensitized CD83+T cell; Have the CTL of stronger cytotoxicity and the activated DC of CD40L induces CD8+T to be divided into, the latter secretes a large amount of IFN one r, has functions such as antiviral, antitumor and immunomodulating.Find in the transplantation immunity research, transplant the alloantigen that the DC2 precursor can be caught the host.And, induce the formation of the CD8+ suppressor T lymphocyte of reaction of donor Th2 type and secretion IL 1 by the CD40L of Allogeneic T cellular expression activation, can cause the donor T cell tolerance.So.DC2 plays a significant role in immunologic tolerance, can be used for autoimmune disease and transplants the sick treatment of related immune.
DC can secrete the various kinds of cell factor and participate in the immunologic function adjusting, and like people DC secretion 1L-1 α, 1L-8,1L-1 β, IFN-α, GM-CSF etc., DC can also secrete multiple chemotactic factor, mediates the chemotaxis of other immunocytes.Some precursor DC such as same type of special sensory nerve ending, very responsive to the various chemical signals in part, and can perceive tissue injury observantly, bring into play immunosurveillance in vivo.
Therefore, BMDC is outpost's type cell of the balance refractory state and the state of alert.When skin is under attack, it will give the alarm.If there is not this reaction, can't start the significant reaction of skin.The uncomfortable of allergic skin feels to have part possibly come from BMDC " extent of reaction ".When receiving warning signal, when perhaps the startup threshold value of tolerance was low, the sensory reaction of skin will be started immediately.And the lower startup threshold value of skin will cause skin overreaction to occur.Therefore, the extent of reaction of adjustment BMDC, when under attack, cell can be made the most appropriate reaction, just can avoid occurring uncomfortable sensation.
On the bionics skin and research proof Castrum nocturum L (CESTRUM LATIFOLIUM) extract that carries out on the BMDC can adjust the startup threshold value of skin BMDC, it is movable not start the skin immunity, improves self tolerance power with this.
Castrum nocturum L has another name called Radix Oenotherae erythrosepalae, and Solanaceae Cestrum plant (Ces-trum nocturnumLinn) originates in tropical America, existing extensively planting in the torrid zone, subtropical zone, and all there is cultivation in China Guangdong, Guangxi, Fujian, Yunnan.Bibliographical information Castrum nocturum L acrid in the mouth, warm in nature, have promoting the circulation of QI to relieve pain, calm effect, among the peoplely mainly be used for treating gastric abscess, also the someone is used for treating tumor.
Castrum nocturum L (CESTRUM LATIFOLIUM) extract promotes to improve the skin tolerance, reduces the extent of reaction of minimum startup threshold value, restores from source property immune system, reduces the sensitivity of skin to stimulating, and makes dermal sensation more comfortable.
Herba Portulacae is a Portulacaceae annual herb plant.Be born in area without shade such as roadside, field and ruins, flower garden.All there is distribution domestic various places.This kind is medicine food dual purpose plant.The herb hyoscine has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quenches the thirst, diuresis; Seed makes eye bright.Modern study, Herba Portulacae also contain abundant SL3 fatty acid and vitamin A appearance material; Vitamin A appearance material can be kept epithelial tissue such as skin, cornea and conjunctival normal function, participates in many oxidizing processs in the body.
In the actual life, outside stimuluss such as ultraviolet, chemical substance, pollution, hot and cold, wind, life stress, endocrine are chaotic, disease internal stimuluss such as (for example diabetes) all possibly cause skin to come to harm.At this moment, skin surface sebum film, iuntercellular lipid, natural moisture preserving ingredients from lossing, skin barrier function is destroyed, and skin keratinization is disorderly, and the skin care ability reduces, and the skin self-repairing capability reduces, and at this moment, it is dry that skin seems, is inflamed easily.
Therefore; Liposoluble substances such as the special ceramide 3 that adds of the present invention, ceramide 6, ceramide 1, phytosphingosine, cholesterol, lauryl dilactic acid sodium; These compositions and iuntercellular lipid conformation are similar, help to repair lipid between corneocyte.Rice aminoacid can play the nature moisturizing factor effect, keeps the skin wet, and strengthens skin moisture-keeping, helps to quicken iuntercellular moisture and Nutrient cycle, strengthens skin barrier function.Rice aminoacid has simultaneously and weakened strong immunity, strengthens the effect of not enough immunity.
After replenishing gene recombinaton hEGF (rhEGF), regenerative cell generates fast, and the quick keratinization of senile cell comes off, and TCS increases greatly, ruptures, the collagen fiber and the elastic fiber of degeneration obtain repairing, and skin barrier also can be strengthened.
When skin receives external cause action (ultraviolet radiation, stimulus generalization are learned composition, mosquito bite etc.), destroy the saturated electrons structure or activate the activity of unsaturated electronic structure in the skin, produce material free radical just with extremely strong oxidisability.Free-radical oxidation destroys the cell membrane of mastocyte and basophil, makes it impaired, degeneration, and the immunocompetence of body is low; Be antigen, the abnormal immunoreactive condition of having created of antibody; Cause cell rupture, thereby secrete histamine, histamine can make skin pore enlarge; The accelerate blood circulation is prone to produce allergic symptoms such as pruritus, redness.The special Herba Portulacae extract that adds of the present invention with antioxygenic property; This extracting solution material has extraordinary antioxygenic property, can remove free radical, gos deep into the release that cell fundamentally suppresses sensitizing factor " histamine "; Regulate immunity, improve the toleration of cell anaphylactogen.
In addition, Rhodophyta algae (RHODOPHYTA) extract can reduce the TNF-alpha content, thereby reduces releive inflammation and redness.Promote the formation of memebrane protein, strengthen the skin protective layer.
Oligopeptide-1, deionized water, being that Shenzhen Gene Biotechnology Co., Ltd. produces, is the commercially available prod.1,2-pentanediol, ceramide 3, ceramide 6, ceramide 1, phytosphingosine and cholesterol are that German goldschmidt chemical corporation is produced, and are the commercially available prod.Rhodophyta algae extract is that friend group of section produces, and is the commercially available prod.Rice aminoacid is that the U.S. international special article company produces, and is the commercially available prod.Herba portulacae extract is produced by the well rich company in Guangzhou hundred, is the commercially available prod.Lauryl dilactic acid sodium and Castrum nocturum L extract are that BASF Aktiengesellschaft produces, and are the commercially available prod.
According to an aspect of the present invention, a kind of cosmetics that improve the skin tolerance and preparation method thereof are provided.
Improve the cosmetics of skin tolerance, be by weight percentage by following constituent content:
Oligopeptide-1 0.002～0.01%;
Deionized water 71～85%;
Rhodophyta algae extract 1～10%;
1,2-pentanediol 3～4.5%;
Rice aminoacid 0.1～1%;
Herba portulacae extract 0.1～5%;
Ceramide 3 0.01～0.1%;
Ceramide 6 0.01～0.1%;
Ceramide 1 0.01～0.1%;
Phytosphingosine 0.01～0.2%;
Cholesterol 0.1～1%;
Lauryl dilactic acid sodium 0.5～2%;
Castrum nocturum L extract 1～5%.
In some embodiments, improve the method for preparing of the cosmetics of skin tolerance, may further comprise the steps:
(1) shift to an earlier date the following raw material of pretreatment:
By each raw material of the accurate weighing of above-mentioned percentage by weight: ceramide 3, ceramide 6, ceramide 1, phytosphingosine, cholesterol and lauryl dilactic acid sodium, and 25% deionized water of Total Water in the prescription;
Deionized water as water, is heated to 80 ℃;
Ceramide 3, ceramide 6, ceramide 1, phytosphingosine, cholesterol and lauryl dilactic acid sodium are heated to 80 ℃ as oil phase;
Then water and oil phase are mixed in the emulsifying pot;
Behind the mix homogeneously, begin to stir and be cooled to 40 ℃ and get final product;
(2) by above-mentioned all the other raw materials of the accurate weighing of percentage by weight: oligopeptide-1, residue deionized water, Rhodophyta algae extract, 1,2-pentanediol, rice aminoacid, Herba portulacae extract and Castrum nocturum L extract;
(3) add raw material in the step (2) one by one, stirring gets final product.
With the cosmetics of this method for preparing made, each contained weight percentages of components and preparation before be the same, the shared ratio of each component remains unchanged.
Beneficial effect of the present invention has the following advantages:
1, method for preparing is simple;
2, skin barrier function is strengthened, and skin is more moist;
3, skin oxidation resistance, autoimmunity improve;
4, there is not dependency.
This product does not have unpleasant taste of Chinese medicine, and prepared product is observed under-5 ℃ ,-15 ℃, 40 ℃ conditions.The material body is even, and outward appearance does not have significant change, this cosmetics good stability.After using a period of time, help improving the tolerance of skin, life-time service, the startup threshold value of adjustment skin BMDC has improved skin stimulation ability to external world.
The specific embodiment
Further specify product of the present invention and method for preparing below in conjunction with specific embodiment:
Embodiment 1
The gross weight of raw material is 100g, wherein:
Oligopeptide-1 0.01g;
Deionized water 85g;
Rhodophyta algae extract 10g;
1,2-pentanediol 3g;
Rice aminoacid 0.1g;
Herba portulacae extract 0.1g;
Ceramide 3 0.01g;
Ceramide 6 0.01g;
Ceramide 1 0.01g;
Phytosphingosine 0.01g;
Cholesterol 0.1g;
Lauryl dilactic acid sodium 0.5g;
Castrum nocturum L extract 1.15g.
Method for preparing may further comprise the steps:
(1) shift to an earlier date the following raw material of pretreatment:
By each raw material of the accurate weighing of above-mentioned percentage by weight: ceramide 3, ceramide 6, ceramide 1, phytosphingosine, cholesterol and lauryl dilactic acid sodium, and 25% deionized water of Total Water in the prescription;
Deionized water as water, is heated to 80 ℃;
Ceramide 3, ceramide 6, ceramide 1, phytosphingosine, cholesterol and lauryl dilactic acid sodium are heated to 80 ℃ as oil phase;
Then water and oil phase are mixed in the emulsifying pot;
Behind the mix homogeneously, begin to stir and be cooled to 40 ℃ and get final product;
(2) by above-mentioned all the other raw materials of the accurate weighing of percentage by weight, oligopeptide-1, residue deionized water, Rhodophyta algae extract, 1,2-pentanediol, rice aminoacid, Herba portulacae extract and Castrum nocturum L extract;
(3) add raw material in the step (2) one by one, stirring gets final product.
Embodiment 2
The gross weight of raw material is 100g, wherein:
Oligopeptide-1 0.002g;
Deionized water 79.998g;
Rhodophyta algae extract 1g;
1,2-pentanediol 4.5g;
Rice amino acid/11 g;
Herba portulacae extract 5g;
Ceramide 3 0.1g;
Ceramide 6 0.1g;
Ceramide 1 0.1g;
Phytosphingosine 0.2g;
Cholesterol 1g;
Lauryl dilactic acid sodium 2g;
Castrum nocturum L extract 5g.
Method for preparing is with embodiment 1.
Embodiment 3
The gross weight of raw material is 100g, wherein:
Oligopeptide-1 0.01g;
Deionized water 71g;
Rhodophyta algae extract 10g;
1,2-pentanediol 4.49g;
Rice amino acid/11 g;
Herba portulacae extract 5g;
Ceramide 3 0.1g;
Ceramide 6 0.1g;
Ceramide 1 0.1g;
Phytosphingosine 0.2g;
Cholesterol 1g;
Lauryl dilactic acid sodium 2g;
Castrum nocturum L extract 5g.
Method for preparing is with embodiment 1.
Embodiment 4
The gross weight of raw material is 100g, wherein:
Oligopeptide-1 0.006g;
Deionized water 75g;
Rhodophyta algae extract 10g;
1,2-pentanediol 4.494g;
Rice amino acid/11 g;
Herba portulacae extract 5g;
Ceramide 3 0.1g;
Ceramide 6 0.1g;
Ceramide 1 0.1g;
Phytosphingosine 0.2g;
Cholesterol 1g;
Lauryl dilactic acid sodium 2g;
Castrum nocturum L extract 1g.
Method for preparing is with embodiment 1.
Embodiment 5
The gross weight of raw material is 100g, wherein:
Oligopeptide-1 0.01g;
Deionized water 82.525g;
Rhodophyta algae extract 5.5g;
1,2-pentanediol 3.75g;
Rice aminoacid 0.55g;
Herba portulacae extract 2.55g;
Ceramide 3 0.055g;
Ceramide 6 0.055g;
Ceramide 1 0.055g;
Phytosphingosine 0.105g;
Cholesterol 0.55g;
Lauryl dilactic acid sodium 1.25g;
Castrum nocturum L extract 3.045g.
Method for preparing is with embodiment 1.
Embodiment 6
The gross weight of raw material is 100g, wherein:
Oligopeptide-1 0.01g;
Deionized water 78.45g;
Rhodophyta algae extract 7.07g;
1,2-pentanediol 4g;
Rice aminoacid 0.7g;
Herba portulacae extract 3g;
Ceramide 3 0.06g;
Ceramide 6 0.07g;
Ceramide 1 0.09g;
Phytosphingosine 0.15g;
Cholesterol 0.4g;
Lauryl dilactic acid sodium 1.5g;
Castrum nocturum L extract 4.5g.
Method for preparing is with embodiment 1.
Come further to set forth the cosmetics stability and the biological effect of raising skin tolerance according to the invention through Test Example.
Test Example 1 stability test
Cosmetics in the embodiment of the invention 1 are got put into several Clear glass bottles and jars in right amount, place 40 ℃ ,-15 ℃ following 24 hours of temperature after the sealing respectively.After this product recovered room temperature as a result, the material body was even, and outward appearance does not have significant change.
The experiment of Test Example 2 biological effects
1, test material: prescription and method for preparing according to embodiment 2 prepare a kind of cosmetics that improve the skin tolerance.
2, test crowd: the beauty parlor client, the tester must be an allergic skin, skin pruritus, redness or decortication phenomenon are arranged, and after smearing 10% lactic acid, tester's skin must respond.The tester must satisfy above-mentioned two conditions simultaneously, just can be as the object of this test.The tester is 200 people altogether, the women, and in age 16-40 year, the mean age is 24.5 years old.
3, test method: each, used 7 days according to the prescription of embodiment and the product of method for preparing preparation with once behind the clean skin of morning and evening every day.
| Improve skin pruritus | Improve red swelling of the skin | Improve skin peeling | |
| Used 15 minutes | 199 people 99.5% | 10 people 5% | 5 people 2.5% |
| Used 1-3 days | 200 people 100% | 198 people 99% | 150 people 75% |
| Used 7 days | 200 people 100% | 200 people 100% | 200 people 100% |
Nearly all user is after being coated with 15 minutes, and the scratchiness of skin is obviously improved, even pruritus no longer, and the improvement rate is 99.5.The situation of red swelling of the skin all can be improved after using 1-3 days, and the improvement rate is 99%.The decortication situation can both well be improved after using a week, and the improvement rate is 100%.Use cosmetics of the present invention after 3 weeks; Those can cause the cosmetics of sense of discomfort or red, swollen, pruritus etc. to skin before re-using; For example contain cosmetics such as fruit acid class, type of whitening or sun-proof class; Can reduce the probability of skin allergy greatly, thereby improve the tolerance of skin, the startup threshold value of adjustment skin BMDC.
The present invention is directed to the aspect that possibly cause skin sensitivity, can adjust the extent of reaction of BMDC.When under attack, cell will be made the most appropriate reaction, avoid occurring uncomfortable incorrect sensation.Help strengthening skin barrier, improve the tolerance of skin, life-time service, the startup threshold value of adjustment skin BMDC has improved skin irritation ability to external world.
Claims (2)
1. improve the cosmetics of skin tolerance, wherein, be by weight percentage by following constituent content:
Oligopeptide-1 0.002～0.01%;
Deionized water 71～85%;
Rhodophyta algae extract 1～10%;
1,2-pentanediol 3～4.5%;
Rice aminoacid 0.1～1%;
Herba portulacae extract 0.1～5%;
Ceramide 3 0.01～0.1%;
Ceramide 6 0.01～0.1%;
Ceramide 1 0.01～0.1%;
Phytosphingosine 0.01～0.2%;
Cholesterol 0.1～1%;
Lauryl dilactic acid sodium 0.5～2%;
Castrum nocturum L extract 1～5%.
2. the method for preparing of the cosmetics of raising skin tolerance according to claim 1 wherein, may further comprise the steps:
(1) shift to an earlier date the following raw material of pretreatment:
Each raw material of the accurate weighing of percentage by weight by claim 1: ceramide 3, ceramide 6, ceramide 1, phytosphingosine, cholesterol, lauryl dilactic acid sodium, 25% deionized water of Total Water in the prescription;
Deionized water as water, is heated to 80 ℃;
Ceramide 3, ceramide 6, ceramide 1, phytosphingosine, cholesterol, lauryl dilactic acid sodium are heated to 80 ℃ as oil phase;
Then water and oil phase are mixed in the emulsifying pot;
Behind the mix homogeneously, begin to stir and be cooled to 40 ℃ and get final product;
(2) by all the other raw materials of the accurate weighing of percentage by weight of claim 1: oligopeptide-1, residue deionized water, Rhodophyta algae extract, 1,2-pentanediol, rice aminoacid, Herba portulacae extract, Castrum nocturum L extract;
(3) add raw material in the step (2) one by one, stirring gets final product.
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| CN103315934A (en) * | 2013-06-21 | 2013-09-25 | 深圳市金因生物技术有限公司 | Composition for promoting opening of skin aquaporin and preparation method thereof |
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| CN107213069A (en) * | 2017-07-04 | 2017-09-29 | 黄美风 | A kind of U.S. face film and preparation method thereof |
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| CN111494299A (en) * | 2020-05-26 | 2020-08-07 | 佛山市谷邦生物科技有限公司 | Ceramide compound muscle-calming repair factor and emulsion thereof |
| US20200345611A1 (en) * | 2019-04-30 | 2020-11-05 | Evonik Operations Gmbh | Composition comprising at least one ceramide, at least one sphingoid base and triethyl citrate |
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| CN103055303A (en) * | 2012-12-26 | 2013-04-24 | 深圳市金因生物技术有限公司 | Composition capable of promoting differentiation of autologous preadipocytes and formation of lipid droplets and preparation method thereof |
| CN103055303B (en) * | 2012-12-26 | 2014-01-01 | 深圳市金因生物技术有限公司 | Composition capable of promoting differentiation of autologous preadipocytes and formation of lipid droplets and preparation method thereof |
| CN103315934A (en) * | 2013-06-21 | 2013-09-25 | 深圳市金因生物技术有限公司 | Composition for promoting opening of skin aquaporin and preparation method thereof |
| CN105168027A (en) * | 2015-08-14 | 2015-12-23 | 百芮生物科技（上海）有限公司 | Essence added with natural anti-allergy repair combination and preparation method of essence |
| CN106691935A (en) * | 2016-12-30 | 2017-05-24 | 北京铁骊青生物科技有限公司 | Skin-repairing composition and preparation method thereof |
| CN107213069A (en) * | 2017-07-04 | 2017-09-29 | 黄美风 | A kind of U.S. face film and preparation method thereof |
| CN108514541A (en) * | 2018-05-10 | 2018-09-11 | 广州珈源日化用品有限公司 | One kind repairing skin barrier Essence containing oligopeptides, ceramide and glycosylglycerol |
| US20200345611A1 (en) * | 2019-04-30 | 2020-11-05 | Evonik Operations Gmbh | Composition comprising at least one ceramide, at least one sphingoid base and triethyl citrate |
| CN110711168A (en) * | 2019-11-29 | 2020-01-21 | 桃源县兴隆米业科技开发有限公司 | Method for preparing amino acid skin care essence by using high essential amino acid rice saving |
| CN111494299A (en) * | 2020-05-26 | 2020-08-07 | 佛山市谷邦生物科技有限公司 | Ceramide compound muscle-calming repair factor and emulsion thereof |
| EP4356898A1 (en) * | 2022-10-20 | 2024-04-24 | Croda Korea Limited | Cosmetic composition comprising ceramides and sphingolipid |
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