CN106176488B - A kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance and its application - Google Patents
A kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
The invention discloses a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance and its application；Melanin excessive secretion can effectively be suppressed by aiming to provide one kind, be reduced due to pigmentation caused by inflammation, the whitening spot-eliminating composition of regulation human body inflammatory reaction balance；Said composition includes following components in parts by weight：0.3 3 parts of palmityl Sodium proline；0.1 1 parts of white pond lily flower extract；0.2 3 parts of VCE；0.005 0.05 parts of glycyrrhiza glabra root extract；0.1 4 parts of Japanese elm root extract；0.05 2 parts of eryngium maritimum callus tissue culture filtrate；Belong to skin care field.
Description
Technical field
It is to be related to a kind of whitening for adjusting human body inflammatory reaction balance to dispel specifically the present invention relates to a kind of composition
Spot composition, the invention further relates to the application of this composition, belongs to skin care field.
Background technology
Most people typically only focuses on sun-proof and whitening, is but easy to ignore the mild skin inflammation occurred in daily life
Disease.Inflammation is a kind of defense reaction of the body for stimulation, and red, swollen, hot, pain is mainly shown as on skin.Cause inflammation
Reason substantially has following a few classes：Biological factors --- bacterium, virus etc.；Physics sex factor --- ultraviolet, high temperature, low temperature
Deng；Chemical sex factor --- xenobiotics, such as strong acid, highly basic；Other factors, such as foreign matter, slough, metamorphosis are anti-
Answer (allergy) etc..
Ultraviolet, local inflammation stimulate (such as allergic dermatitis, solar dermatitis, inflammation, black spot) or hormone in vivo
Suddenly change, can all stimulate human body release activation melanin formation signal, produce excessive melanin, cause skin color occur
Plain calmness (color spot), and disappear (obscure) with skin gloss.
Therefore, developing a kind of whitening spot-eliminating composition that is safe, can effectively adjusting human body inflammatory reaction balance is
The problem of this area is in the urgent need to address.
The content of the invention
In view of the above-mentioned problems, the first object of the present invention, which is to provide one kind, can effectively suppress melanin excessive secretion, subtract
Less due to pigmentation caused by inflammation, the whitening spot-eliminating composition of regulation human body inflammatory reaction balance.
The second object of the present invention is to provide above-mentioned whitening spot-eliminating composition as the application of skin-care product additive.
Therefore, the technical scheme that the present invention is provided is such：
A kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance, including following components in parts by weight：
0.3-3 parts of palmityl Sodium proline；
0.1-1 parts of white pond lily flower extract；
0.2-3 parts of VCE；
0.005-0.05 parts of glycyrrhiza glabra root extract；
0.1-4 parts of Japanese elm root extract；
0.05-2 parts of eryngium maritimum callus tissue culture filtrate.
Further, a kind of whitening spot-eliminating composition of above-mentioned regulation human body inflammatory reaction balance, in addition to long heart card
0.1-4 parts of handkerchief algae extract.
Further, the whitening spot-eliminating composition of above-mentioned a kind of regulation human body inflammatory reaction balance, in addition to heavenly maiden's wood
Blue extract 0.1-2.5 parts.
Further, a kind of whitening spot-eliminating composition of above-mentioned regulation human body inflammatory reaction balance, in addition to gorgonian
0.1-3 parts of extract.
Further, a kind of whitening spot-eliminating composition of above-mentioned regulation human body inflammatory reaction balance, in addition to uva ursi
0.1-2 parts of extract.
Further, a kind of whitening spot-eliminating composition of above-mentioned regulation human body inflammatory reaction balance, in addition to coarse cap
0.1-2 parts of berry extract.
Further, the whitening spot-eliminating composition of above-mentioned a kind of regulation human body inflammatory reaction balance, by following weight parts
Component composition：0.3-3 parts of palmityl Sodium proline, 0.1-1 parts of white pond lily flower extract, 0.2-3 parts of VCE,
0.005-0.05 parts of glycyrrhiza glabra root extract, 0.1-4 parts of Japanese elm root extract, eryngium maritimum callus tissue culture filtrate
0.05-2 parts, 0.1-4 parts of kappaphycus algae extract, 0.1-2.5 parts of extract of magnolia sieboldii, 0.1-3 parts of gorgonian extract,
0.1-2 parts of black bearberry leaf extract, coarse 0.1-2 parts of cap berry extract.
Further, a kind of whitening spot-eliminating composition of above-mentioned regulation human body inflammatory reaction balance, described strand
Perverse celery callus tissue culture filtrate is made by following step：By the explant of eryngium maritimum setup action evoked callus
Body, on superclean bench, first soaks 5min with 70% ethanol, aseptic water washing is then used again 3~5 times, is inhaled with sterilizing filter paper
Dry surface moisture, is cut into 0.5cm × 0.5cm × 0.3cm fritter respectively, is inoculated on different inducing cultures；The training
It is MS, B5 medium to support base, additional plant hormone 2,4-D, 6-BA, NAA, in culture medium plus sucrose 30g, agar 5.5g/L, training
The pH value for supporting base is 5.8, the evoked callus under the conditions of light culture, and cultivation temperature is 25~27 DEG C, illumination 10h/d, culture
20 days, nutrient solution is collected by filtration, filtrate is collected by filtration, sterilizes.
Compared with prior art, the technical scheme that the present invention is provided has the following advantages that：
1st, the composition that provides of the present invention is by palmitic acid acyl Sodium proline, white pond lily flower extract, VCE, light fruit
Licorice root extract, eryngium maritimum callus tissue culture filtrate, Japanese elm root extract are rationally compounded, and each component collaboration is made
With, skin resistance environmental stimuli is helped, alleviates pain caused by temperature-sensitive, it is effective to reduce due to the excessive black that inflammatory stimulus are produced
Pigmentation caused by element and inflammation, reaches the effect of whitening spot-removing.
2nd, the present invention composition that provides is by kappaphycus algae extract, extract of magnolia sieboldii, gorgonian extract
One or more of which acts synergistically with other components of the present invention, can effectively suppress the release of histamine and the production of inflammatory factor
It is raw, suppress the expression of inflammation medium, there is antiallergic anti-inflammatory and suppress atopic dermatitis, effectively protection skin is remote
The infringement of ultraviolet and other pungents, so as to reduce because of situations such as skin caused by inflammation is obscure, color spot.In addition,
Also there is effect that is anti-oxidant, suppressing melanosome transfer.
3rd, the composition that provides of the present invention is by black bearberry leaf extract, coarse cap berry extract, kappaphycus algae extract, day
Female's extract of magnolia, the one or more of which of gorgonian extract act synergistically with other components of the present invention, effectively suppress black
Pigment excessive secretion, is reduced due to pigmentation caused by inflammation, the light tender white muscle skin of spot, allows skin to shine the gloss of health,
There is delay skin aging simultaneously.
Embodiment
With reference to embodiment, the claim to the present invention is described in further detail, but is not constituted pair
Any limitation of the present invention, the modification of anyone limited number of time made in the claims in the present invention protection domain etc still exists
Within the claims of the present invention.
It is worth noting that, unless otherwise indicated, various components used in the present invention are this area current material, can
Bought by commercial channel and obtain or be made by existing method.
Palmityl Sodium proline, white pond lily flower extract are purchased matches BIC Corp in France；Kappaphycus algae extract is adopted
It is purchased from the long enterprise development Co., Ltd of marine rainbow；Extract of magnolia sieboldii, gorgonian extract, Japanese elm root extract are purchased in wide
Hao Bo Co., Ltds of state city hundred；Black bearberry leaf extract, coarse cap berry extract are purchased in Guangzhou Ao Yuan trade Co., Ltds.
Eryngium maritimum callus tissue culture filtrate is made by following step：By eryngium maritimum setup action callus induction
The explant of tissue, on superclean bench, first soaks 5min with 70% ethanol, aseptic water washing is then used again 3~5 times, uses
Sterilizing filter paper blots surface moisture, and 0.5cm × 0.5cm × 0.3cm fritter is cut into respectively, is inoculated into different inducing cultures
On；The culture medium is MS, B5 medium, additional plant hormone 2,4-D, 6-BA, NAA, in culture medium plus sucrose 30g, agar
5.5g/L, the pH value of culture medium is 5.8, and the evoked callus under the conditions of light culture, cultivation temperature is 25~27 DEG C, illumination
10h/d, is cultivated 20 days, nutrient solution is collected by filtration, filtrate is collected by filtration, and sterilizes, and detection is produced.
Embodiment 1
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 3g, white pond lily flower extract 0.1g, VCE 3g, glycyrrhiza glabra root extract
0.005g, Japanese elm root extract 4g, eryngium maritimum callus tissue culture filtrate 0.05g.
Embodiment 2
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 0.3g, white pond lily flower extract 1g, VCE 0.2g, glycyrrhiza glabra root extract
0.05g, Japanese elm root extract 0.1g, eryngium maritimum callus tissue culture filtrate 2g.
Embodiment 3
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 1g, white pond lily flower extract 0.2g, VCE 0.5g, glycyrrhiza glabra root extract
0.01g, Japanese elm root extract 2g, eryngium maritimum callus tissue culture filtrate 0.1g, kappaphycus algae extract 4g.
Embodiment 4
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2g, white pond lily flower extract 0.5g, VCE 0.8g, glycyrrhiza glabra root extract
0.01g, Japanese elm root extract 1g, eryngium maritimum callus tissue culture filtrate 2g, extract of magnolia sieboldii 0.1g.
Embodiment 5
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 1.5g, white pond lily flower extract 0.3g, VCE 2g, glycyrrhiza glabra root extract
0.04g, Japanese elm root extract 1.5g, eryngium maritimum callus tissue culture filtrate 1.2g, gorgonian extract 1.2g.
Embodiment 6
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 0.8g, white pond lily flower extract 0.6g, VCE 0.4g, glycyrrhiza glabra root extract
0.02g, Japanese elm root extract 1.8g, eryngium maritimum callus tissue culture filtrate 1g, black bearberry leaf extract 0.8g.
Embodiment 7
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2.5g, white pond lily flower extract 0.9g, VCE 2.2g, glycyrrhiza glabra root extract
0.03g, Japanese elm root extract 3.5g, eryngium maritimum callus tissue culture filtrate 0.15g, coarse cap berry extract 1.5g.
Embodiment 8
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 1.8g, white pond lily flower extract 0.8g, VCE 0.8g, glycyrrhiza glabra root extract
0.04g, Japanese elm root extract 2.5g, eryngium maritimum callus tissue culture filtrate 1.5g, kappaphycus algae extract 1.8g, day
Female's extract of magnolia 1.8g.
Embodiment 9
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 1.1g, white pond lily flower extract 0.9g, VCE 0.3g, glycyrrhiza glabra root extract
0.025g, Japanese elm root extract 2.8g, eryngium maritimum callus tissue culture filtrate 0.19g, kappaphycus algae extract 2.6g,
Gorgonian extract 0.6g.
Embodiment 10
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2.1g, white pond lily flower extract 0.2g, VCE 0.2g, glycyrrhiza glabra root extract
0.05g, Japanese elm root extract 0.1g, eryngium maritimum callus tissue culture filtrate 2g, kappaphycus algae extract 0.1g, black bearberry
Leaf extract 2g.
Embodiment 11
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2.9g, white pond lily flower extract 0.7g, VCE 1.7g, glycyrrhiza glabra root extract
0.045g, Japanese elm root extract 3.6g, eryngium maritimum callus tissue culture filtrate 0.08g, kappaphycus algae extract 4g, slightly
Rough cap berry extract 0.1g.
Embodiment 12
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 0.8g, white pond lily flower extract 0.6g, VCE 0.7g, glycyrrhiza glabra root extract
0.035g, Japanese elm root extract 4g, eryngium maritimum callus tissue culture filtrate 0.08g, kappaphycus algae extract 1.5g, day
Female extract of magnolia 1.8g, gorgonian extract 3g.
Embodiment 13
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2.3g, white pond lily flower extract 0.6g, VCE 2.3g, glycyrrhiza glabra root extract
0.04g, Japanese elm root extract 1.1g, eryngium maritimum callus tissue culture filtrate 0.4g, kappaphycus algae extract 0.3g, willow
Os Corallii extract 2g, black bearberry leaf extract 0.7g.
Embodiment 14
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 1.9g, white pond lily flower extract 0.7g, VCE 0.5g, glycyrrhiza glabra root extract
0.02g, Japanese elm root extract 0.3g, eryngium maritimum callus tissue culture filtrate 0.5g, extract of magnolia sieboldii 0.6g, Liu Shan
Coral extract 2g, black bearberry leaf extract 0.7g.
Embodiment 15
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2.1g, white pond lily flower extract 0.7g, VCE 0.9g, glycyrrhiza glabra root extract
0.009g, Japanese elm root extract 0.6g, eryngium maritimum callus tissue culture filtrate 0.09g, gorgonian extract 0.7g, black bearberry
Leaf extract 0.9g, coarse cap berry extract 0.8g.
Embodiment 16
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 0.5g, white pond lily flower extract 0.8g, VCE 0.7g, glycyrrhiza glabra root extract
0.03g, Japanese elm root extract 0.8g, eryngium maritimum callus tissue culture filtrate 0.09g, extract of magnolia sieboldii 0.9g, willow
Os Corallii extract 0.9g, coarse cap berry extract 0.7g.
Embodiment 17
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 2.7g, white pond lily flower extract 0.8g, VCE 2.6g, glycyrrhiza glabra root extract
0.01g, Japanese elm root extract 2.3g, eryngium maritimum callus tissue culture filtrate 0.6g, kappaphycus algae extract 2.3g, day
Female extract of magnolia 2.2g, black bearberry leaf extract 0.9g.
Embodiment 18
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 0.7g, white pond lily flower extract 0.6g, VCE 2.4g, glycyrrhiza glabra root extract
0.04g, Japanese elm root extract 0.35g, eryngium maritimum callus tissue culture filtrate 1.5g, kappaphycus algae extract 1.5g,
Extract of magnolia sieboldii 2g, black bearberry leaf extract 1.6g, coarse cap berry extract 1.6g.
Embodiment 19
The whitening spot-eliminating composition for a kind of regulation human body inflammatory reaction balance that the present invention is provided, by following mass number components
Composition：Palmityl Sodium proline 1.3g, white pond lily flower extract 0.7g, VCE 2.3g, glycyrrhiza glabra root extract
0.03g, Japanese elm root extract 2.1g, eryngium maritimum callus tissue culture filtrate 1.3g, kappaphycus algae extract 2.6g, day
Female extract of magnolia 2.4g, gorgonian extract 2.6g, black bearberry leaf extract 1.4g, coarse cap berry extract 1.4g.
When specifically used, the whitening spot-eliminating composition for being used to adjust human body inflammatory reaction balance prepared by the present invention is added
Into white emulsification system or white shape gel-type vehicle, its addition accounts for the 0.5-6% of skin care item gross mass, and adding method is：Will
Palmityl Sodium proline and white pond lily flower extract are added after (in the oil phase of heat) or emulsification are added before emulsification, treat water phase and an oil phase
When mixture after emulsification is reduced to 40-45 DEG C, add in advance dissolved VCE, glycyrrhiza glabra root extract,
Japanese elm root extract, kappaphycus algae extract, extract of magnolia sieboldii, gorgonian extract, black bearberry leaf extract, coarse cap
Berry extract and eryngium maritimum callus tissue culture filtrate, stir.
In order to better illustrate advantages of the present invention, it is given below and is put down provided by the present invention for regulation human body inflammatory reaction
The efficacy test of the whitening spot-eliminating composition of weighing apparatus：
(1) anti-inflammatory is tested
Hyaluronidase is the participant of type i allergic reaction and tumor cell proliferation, it with inflammation, make and quick have strong correlation
Property.Therefore, suppress the activity of hyaluronidase, hyaluronic acid can be made not to be decomposed to maintain its normal physiological function, again
Anti-inflammatory, antiallergy and the effect for cooperateing with moisturizing can be reached.
Test method：First the composition of embodiment 1,3,5,7,9,11,13,15,17,19 is first dissolved with a small amount of DMSO
Afterwards, 1mg/ml sample solution is made into acetic acid buffer solution, it is standby.By hyaluronidase activity Inhibition test, determine anti-
The absorbance of solution after answering, calculates the inhibiting rate to hyaluronidase activity, is used to adjust human body inflammation to evaluate the present invention
React the anti-inflammatory effect of the whitening spot-eliminating composition of balance.It the results are shown in Table shown in 1.
Inhibiting rate of the table 1 to hyaluronidase activity
As a result show, U.S. for being used to adjust human body inflammatory reaction balance of embodiment 1,3,5,7,9,11,13,15,17,19
White spot-eliminating composition can effectively suppress hyaluronidase activity；Illustrate that the present invention carries palmityl Sodium proline, white pond lily flower
Take thing, VCE, glycyrrhiza glabra root extract, Japanese elm root extract, eryngium maritimum callus tissue culture filtrate,
Kappaphycus algae extract, extract of magnolia sieboldii, gorgonian extract, black bearberry leaf extract, coarse cap berry extract are carried out
Rationally compound, with significant anti-inflammatory effect.
(2) anti-oxidant experiment
Free radical is that a class property is active, the chemical substance with extremely strong oxidability, a large amount of freedom produced in body
Base can also cause damage to skin, accelerate color spot, the formation of melanin.DPPH is a kind of long-life free radical of stabilization, when having
In the presence of free radical scavenger, DPPH light absorbs are weakened due to being matched with its single electron, material is evaluated whereby and is removed freely
The ability of base, so as to evaluate its oxidation resistance.
Test method：After first the composition of embodiment 2,4,6,8,10,12,14,16,18 is first dissolved with a small amount of DMSO,
1mg/ml sample solution is made into distilled water, it is standby.By in DPPH free radicals and testing, absorbance is determined, is calculated pair
The clearance rate of DPPH free radicals, the antioxygen for adjusting the whitening spot-eliminating composition of human body inflammatory reaction balance to evaluate the present invention to be used for
Change effect.It the results are shown in Table shown in 2.
Clearance rate of the table 2 to DPPH free radicals
As a result show, the whitening for being used to adjust human body inflammatory reaction balance of embodiment 2,4,6,8,10,12,14,16,18
Spot-eliminating composition can effectively remove DPPH free radicals；Illustrate the present invention by palmityl Sodium proline, white pond lily flower extract, dimension
Raw element C ethylethers, glycyrrhiza glabra root extract, Japanese elm root extract, eryngium maritimum callus tissue culture filtrate, kappaphycus
Algae extract, extract of magnolia sieboldii, gorgonian extract, black bearberry leaf extract, coarse cap berry extract are rationally compounded,
With significant antioxidant effect.
(3) human trial
First, by embodiment 1-19 composition, it is added separately in face cream matrix, the face cream of whitening spot-removing is made, according to
It is secondary to be calculated as face cream 1-19.Wherein：Composition and the mass ratio of face cream matrix 3.5:96.5, the preparation method of face cream matrix is according to this
Field common process and raw material are carried out.
Test specimen：Face cream 1-19 and face cream matrix, a certain commercially available whitening spot-removing face cream.
Experiment crowd：Selection skin is easily burnt, easy healthy volunteer 210 tanned, with color spot, age 25-50 Sui,
Average 35 years old, to cosmetics without allergy, facial no acute inflammation, hormone medicine or immunodepressant be not used, do not participate in it
His clinical test, external preparation is not smeared.21 groups are randomly divided into, every group of 10 people use face cream 1-19 and face cream base respectively successively
Matter, a certain commercially available whitening spot-removing face cream.
Test method：Each group volunteer uniformly smears corresponding product with after warm water cleaning skin in face, sooner or later daily
It is each 1 time, continuous to use 8 weeks, evaluated and tested with dermal melanin and ferroheme tester (German CK MPA9-Mexameter MX18)
Subject uses the change of dermal melanin content before and after corresponding product, so that it is determined that the whitening effect of product；It is complete with VISIA
Face imaging analysis instrument test subject uses the change of skin splash content before and after corresponding product, so that it is determined that the nti-freckle of product
Effect.It the results are shown in Table shown in 3.
Table 3 uses three months dermal melanins and Colour patterns rate (n=10)
As a result show, embodiment 1-19 melanin rate of change and Colour patterns rate are above face cream matrix and commercially available whitening
Nti-freckle face cream；Illustrate that the present invention carries palmityl Sodium proline, white pond lily flower extract, VCE, glycyrrhiza glabra root
Take thing, Japanese elm root extract, eryngium maritimum callus tissue culture filtrate, kappaphycus algae extract, extract of magnolia sieboldii,
Gorgonian extract, black bearberry leaf extract, coarse cap berry extract are rationally compounded, with significant whitening spot-removing effect.
In addition, the present invention allows volunteer to continue face cream 1-19 on probation in three months, following overall merit feedback is obtained：
Skin becomes cleaner after 88% volunteer's reflection face cream 1-19 on probation；Skin after 91% volunteer's reflection face cream 1-19 on probation
The more shining coloured silk of color；Color spot is thin out after 92% volunteer's reflection face cream 1-19 on probation；70% volunteer's reflection face cream 1-19 on probation
The color spot of large area is reduced afterwards；Skin polishes after 96% volunteer's reflection face cream 1-19 on probation；93% volunteer's reflection
Skin more water moistens after face cream 1-19 on probation；It is existing without the discomfort such as any skin allergy after 100% volunteer reflection face cream 1-19 on probation
As.
In summary, the whitening spot-eliminating composition for the regulation human body inflammatory reaction balance that the present invention is provided, each component collaboration
Act on, effectively help skin resistance environmental stimuli, reduce due to caused by the excessive melanin and inflammation of inflammatory stimulus generation
Pigmentation, the light tender white muscle skin of spot allows skin to shine the gloss of health, while there is delay skin aging, safety
It is non-stimulated.
Claims (9)
1. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance, it is characterised in that the group including following weight parts
Point：
0.3-3 parts of palmityl Sodium proline；
0.1-1 parts of white pond lily flower extract；
0.2-3 parts of VCE；
0.005-0.05 parts of glycyrrhiza glabra root extract；
0.1-4 parts of Japanese elm root extract；
0.05-2 parts of eryngium maritimum callus tissue culture filtrate.
2. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
Also include 0.1-4 parts of kappaphycus algae extract.
3. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
Also include 0.1-2.5 parts of extract of magnolia sieboldii.
4. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
Also include 0.1-3 parts of gorgonian extract.
5. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
Also include 0.1-2 parts of black bearberry leaf extract.
6. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
Also include coarse 0.1-2 parts of cap berry extract.
7. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
It is made up of following components in parts by weight：0.3-3 parts of palmityl Sodium proline, 0.1-1 parts of white pond lily flower extract, vitamin C second
0.2-3 parts of base ether, 0.005-0.05 parts of glycyrrhiza glabra root extract, 0.1-4 parts of Japanese elm root extract, eryngium maritimum callus
0.05-2 parts of culture filtrate, 0.1-4 parts of kappaphycus algae extract, 0.1-2.5 parts of extract of magnolia sieboldii, gorgonian is extracted
0.1-3 parts of thing, 0.1-2 parts of black bearberry leaf extract, coarse 0.1-2 parts of cap berry extract.
8. a kind of whitening spot-eliminating composition for adjusting human body inflammatory reaction balance according to claim 1, it is characterised in that
Described eryngium maritimum callus tissue culture filtrate is made by following step：By eryngium maritimum setup action callus induction group
The explant knitted, on superclean bench, first soaks 5min with 70% ethanol, then again with aseptic water washing 3~5 times, with going out
Bacterium filter paper blots surface moisture, and 0.5cm × 0.5cm × 0.3cm fritter is cut into respectively, is inoculated into different inducing cultures
On；The culture medium is MS, B5 medium, additional plant hormone 2,4-D, 6-BA, NAA, in culture medium plus sucrose 30g, agar
5.5g/L, the pH value of culture medium is 5.8, and the evoked callus under the conditions of light culture, cultivation temperature is 25~27 DEG C, illumination
10h/d, cultivates 20 days, nutrient solution is collected by filtration, filtrate is collected by filtration, and sterilizes.
9. a kind of whitening spot-eliminating composition of regulation human body inflammatory reaction balance described in claim 1 is used as skin-care product additive
Application.
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| CN109199984B (en) * | 2018-11-13 | 2021-07-02 | 广东丸美生物技术股份有限公司 | Whitening and skin-care composition capable of changing powder into cream and preparation method thereof |
| CN111494255B (en) * | 2020-06-03 | 2022-09-30 | 广东芭薇生物科技股份有限公司 | Composition containing ginseng cordyceps sinensis fermentation extract and application of composition in cosmetics |
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| CN102293733B (en) * | 2011-08-25 | 2012-07-04 | 北京药谷传奇医药科技开发有限公司 | Overall whitening and speckle removal skin care product |
| CN104042545B (en) * | 2014-06-10 | 2016-04-27 | 刘佰岭 | A kind ofly subtract skin-protection product in age for cytogene Regeneration and Repair |
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