CN109199984B

CN109199984B - Whitening and skin-care composition capable of changing powder into cream and preparation method thereof

Info

Publication number: CN109199984B
Application number: CN201811348027.4A
Authority: CN
Inventors: 凡青; 孙云起; 孙怀庆; 裴运林; 聂艳峰
Original assignee: Guangdong Marubi Biological Technology Co Ltd
Current assignee: Guangdong Marubi Biological Technology Co Ltd
Priority date: 2018-11-13
Filing date: 2018-11-13
Publication date: 2021-07-02
Anticipated expiration: 2038-11-13
Also published as: CN109199984A

Abstract

The invention belongs to the field of cosmetics, and particularly relates to a whitening and skin-care composition capable of changing powder into cream, which is prepared from the following components in percentage by weight: 1-20% of silicon dioxide, 1-10% of humectant, 0.1-0.8% of preservative, 120.1-5% of C12-14 alkanol polyether, 1-10% of emollient, 1-10% of skin conditioner and the balance of water. The composition provided by the invention contains 10 active ingredients, and through scientific and reasonable matching, each component generates a synergistic interaction effect, has a remarkable removing effect on pigmentation caused by ultraviolet irradiation, medicine taking and organism inflammatory reaction, and also has the effect of repairing facial red blood streak.

Description

Whitening and skin-care composition capable of changing powder into cream and preparation method thereof

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a whitening and skin-care composition capable of changing powder into cream and a preparation method thereof.

Background

Ultraviolet radiation, local inflammatory irritation, sudden changes in body hormones, or the administration of drugs can cause skin pigmentation, resulting in dull skin.

However, the deposition of facial pigment is often caused by the influence of more than one factor, but the whitening skin care products in the market are limited to the deposition of pigment caused by a single factor, such as the deposition of pigment caused by ultraviolet irradiation or the stimulation of inflammation, and the treatment of the deposition of pigment caused by three or two of the factors is rare. For example, Chinese patent application CN106176488A discloses a whitening and freckle-removing composition for regulating the balance of body inflammatory response and an application thereof, wherein the composition comprises 0.3-3 parts of sodium palmitoyl prolinate, 0.1-1 part of a water lily flower extract, 0.2-3 parts of vitamin C ethyl ether, 0.005-0.05 part of a glycyrrhiza glabra root extract, 0.1-4 parts of a vernonia ulmarius root extract and 0.05-2 parts of a periwinkle callus culture filtrate. But it has no obvious effect on the deposition of pigment on the face caused by drug stimulation. Therefore, when consumers use the product, the using effect is good and the whitening effect is excellent for some consumers, but some consumers are dissatisfied with the whitening effect and cannot meet the requirements of most consumers.

Secondly, the currently marketed whitening skin care products are divided into the following dosage forms: aqueous, emulsion, cream, jelly, etc. However, the above dosage forms generally have the problems that the whitening active ingredients are unstable and are easily oxidized or lose efficacy due to environmental influences, while the common powdery whitening powders, such as vitamin C powder, have no problem that the active ingredients are unstable, but need to be dissolved first when in use, and the use steps are complicated.

Therefore, there is a need for a whitening product that can solve the above problems at the same time.

Disclosure of Invention

The invention aims to provide a powder-to-cream whitening and skin-care composition and a preparation method thereof, the composition is prepared into a powder-to-cream whitening product by adsorbing water molecules by powder, the problem that the traditional dosage form easily causes instability of active ingredients is solved, the product contains water, additional dissolution is not needed, the powder is instantly liquefied into a cream shape when being applied, and the composition has a remarkable removing effect on pigment deposition caused by ultraviolet irradiation, body inflammatory reaction and drug stimulation.

In order to achieve the purpose, the invention adopts the following technical scheme: a whitening and skin-care composition of powder-to-cream is prepared from the following components in percentage by weight: 1-20% of silicon dioxide, 1-10% of humectant, 0.1-0.8% of preservative, 120.1-5% of C12-14 alkanol polyether, 1-10% of emollient, 1-10% of skin conditioner and the balance of water.

The key point of the invention is to provide a novel whitening product, which is prepared by emulsifying an oil phase and an aqueous phase which are immiscible with each other into a uniform liquid by using C12-14 alkanol polyether-12, and adding silicon dioxide to adsorb an emulsion containing the oil phase and the aqueous phase to form a microcapsule with an outer shell of aggregated silicon dioxide and an intermediate water content. Experiments prove that the water content of the whitening skin care product prepared by the invention is up to more than 70%.

Further, the humectant is selected from glycerin and/or butylene glycol.

Further, the humectant is prepared from glycerin and butylene glycol in a ratio of 1: (0.5-1) in terms of weight ratio. Wherein the glycerin can absorb moisture in the air, moisturize the eye skin, and effectively lock the moisture of the skin by matching with the butanediol

Further, the preservative is selected from at least one of methylparaben, propylparaben and phenoxyethanol. In one embodiment of the invention, the preservative is prepared from methyl hydroxybenzoate, propyl hydroxybenzoate and phenoxyethanol according to a ratio of 1: (5-8) in terms of weight ratio. The three preservatives are used in a matched manner, so that the integral dosage of the preservatives can be reduced, the corrosion resistance can be enhanced, and the whitening skin care product can be effectively prevented from mildewing and deteriorating.

Further, the emollient is prepared from polydimethylsiloxane and shea butter according to a ratio of 1: (0.1-1) in terms of weight ratio. Among them, the low surface tension of silicone oil, good lubrication to the skin, easy dispersion of other components of the cosmetic and spreading into a thin film on the skin, giving a silky skin feel. The shea butter has light texture and is smooth like silk, is pure natural vegetable oil, has super-strong antioxidant effect, is mild and non-irritant, has very close indexes to the oil secreted by a human body, contains rich non-saponified components which are easily absorbed by the human body, and can realize deep moistening and prevent drying and cracking by matching the shea butter and the non-saponified components.

Further, the skin conditioner comprises the following components in parts by weight: 1-10 parts of hydrolyzed yeast protein, 1-10 parts of turmeric root extract, 1-10 parts of tea extract, 1-10 parts of gentiana lutea root extract, 1-10 parts of coastal cress callus culture filtrate, 1-10 parts of sea fennel callus culture filtrate, 1-10 parts of wine extract, 1-10 parts of ganoderma lucidum extract, 1-10 parts of hydrolyzed wheat fine powder and 1-10 parts of blackberry lily root extract. The above components are commercially available, and specific information is as follows:

hydrolyzing the yeast protein: purchased from International Special Products (ISP) corporation, usa.

Turmeric (CURCUMALONGA) root extract: purchased from sabinda corporation, usa.

Tea (CAMELLIA SINENSIS) leaf extract: purchased from Bailander (BLOAND) of Korea.

Coastal celery (ERYNGIUM MARITIMUM) callus culture filtrate: available from Biohote, France (BIOTECH MARINE).

Sea fennel (CRITHMUM MARITIMUM) callus culture filtrate: available from Biohote, France (BIOTECH MARINE).

Extract of the root of gentiana lutea (gentiana lutea): purchased from tokyo corporation, japan.

Wine extract: (GREENTECH)

Ganoderma (Ganoderma lucidum) extract: purchased from Bailander (BLOAND) of Korea.

Hydrolyzing the wheat fine powder: purchased from Soliance, France.

Belamcanda CHINENSIS (Belamcanda CHINENSIS) root extract: purchased from Nippon Natural Meijian Co., Ltd.

Surprisingly, it has been found that the composition containing the active ingredients can achieve positive effects on ultraviolet irradiation, body inflammatory reaction and pigmentation caused by taking medicines, and tests prove that the eye skin color L of three pigmentation patients can be obtained after 4 weeks of using the composition of the invention^*The value, the scattered light brightness and the comprehensive brightness rate are obviously improved, the spot occupancy rate is obviously reduced, the facial mask has the function of obviously removing facial pigments caused by various factors, and meanwhile, the facial mask also has an obvious repairing function on facial red blood filaments. Surprisingly, it can also be seen from the test results that the above-mentioned effect is achieved by the combined action of the above-mentioned 10 components, since it was found that, by removing one or both of the components, it is not possible to achieve the same or similar technical effect.

It is another object of the present invention to provide a method for preparing a skin care composition as described above, comprising the steps of:

s1, taking emollient, preservative and C12-14 alkanol polyether-12, heating to dissolve, and fully mixing to form phase A;

s2, uniformly stirring the moisturizing agent, the water and the skin conditioner to form a phase B;

s3, adding the phase A into the phase B under the stirring state, stirring for 1-5 min, stirring and heating to 80 ℃, stirring at the speed of 900r/min, and stirring for 10min to form a phase C;

and S4, mixing the silicon dioxide and the C, stirring at a high speed, taking out, sieving, and removing uneven particles to obtain the silicon dioxide/carbon composite material.

The invention also aims to provide the application of the whitening and skin-care composition in removing facial pigmentation and repairing facial red blood streak.

Further, the melanin deposits include pigmentation caused by ultraviolet irradiation, drug stimulation, or an inflammatory reaction of the body.

The pigmentation resulting from the administration of drugs described herein include, but are not limited to, those resulting from the administration of chlorpromazine, amiodarone, tetracycline, memantine, bleomycin, cyclophosphamide, antimalarial chloroquine and quinuclidine and other phenothiazines, which, when administered, cause a change in the skin pigmentation at the exposed site.

The invention has the following advantages:

1) the composition provided by the invention contains 10 active ingredients, and through scientific and reasonable matching, each component generates a synergistic interaction effect, has a remarkable removing effect on pigmentation caused by ultraviolet irradiation, medicine taking and organism inflammatory reaction, and can repair facial red blood streak.

2) The composition provided by the invention forms a new preparation formulation, overcomes the problem of unstable active ingredients in the traditional solution formulation, simultaneously does not need to be dissolved by water when in use, is instantly liquefied when being applied, is simple to use, and brings different experience and feeling to consumers.

Detailed Description

The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.

Whitening composition formulations of examples 1 to 3 and comparative examples 1 to 3

The preparation method comprises the following steps:

s1, taking shea butter, polydimethylsiloxane, methyl hydroxybenzoate, propyl hydroxybenzoate and C12-14 alkanol polyether-12, heating and dissolving the materials in proportion, fully mixing the materials, and cooling to 45 ℃ to form a phase A;

s2, uniformly stirring glycerol, butanediol, phenoxyethanol, water, hydrolyzed yeast protein, turmeric root extract, tea extract, coastal cress callus culture filtrate, sea fennel callus culture filtrate, yellow gentian root extract, wine extract, ganoderma lucidum extract, hydrolyzed wheat fine powder and blackberry lily root extract to form a phase B;

s3, adding the phase A into the phase B under the stirring state, stirring for 3min, stirring and heating to 80 ℃, stirring at the speed of 900r/min, and stirring for 10min to form a phase C;

Test example I test for Heat and Cold resistance

The whitening skin care product disclosed in the embodiment 1-3 is placed in an environment at 45 ℃ and is heat-resistant for 24 hours, and no agglomeration or water precipitation phenomenon exists in each group.

Test example two, test of anticorrosive Properties

The whitening skin care product disclosed in the embodiment 1-3 is tested according to a microorganism preservative efficacy test method of United states Pharmacopeia USP32(51), and test results show that the sample disclosed in the embodiment 1-3 has good microorganism control capability.

Test example three, whitening Performance test

3.1 testing of eye pigmentation caused by administration of chlorpromazine

All subjects who took chlorpromazine-induced eye pigment were applied with the composition described in examples 1-3, comparative examples 1-3 and Chinese patent application CN106176488A (control) for 4 weeks to 10 subjects per group, and after 4 weeks, the skin brightness (L) of the eyes of all subjects was measured^*Value), scattered light brightness, comprehensive brightness ratio, spot occupancy, VISIA photographing, visual evaluation, data analysis, comparison of whether the results before and after trial of the test object are different, and statistical variation values, the test results are shown in table 1 below.

TABLE 1 test results on eye pigmentation caused by administration of chlorpromazine

Note: in comparison with the example 1, the method of the present invention,^**P＜0.01，^*P＜0.05。

3.2 removal test for pigmentation due to body inflammation

All the body partsSubjects with inflammation-induced pigmentation eye was treated with the compositions described in examples 1 to 3, comparative examples 1 to 3 and Chinese patent application CN106176488A (control) for 4 weeks, 10 subjects per group, and 4 weeks later, all subjects were tested for eye skin color L^*Values, scattered light brightness, comprehensive brightness ratio and spot occupancy, VISIA photographing, visual evaluation, data analysis, comparison of whether the results before and after trial of the test object are different, and statistical variation values, wherein the test results are shown in table 2 below.

TABLE 2 results of the removal test of pigmentation due to body inflammation

3.3 test for removal of pigmentation by ultraviolet irradiation

All subjects with pigmentation due to ultraviolet irradiation were subjected to the composition described in examples 1 to 3, comparative examples 1 to 3 and Chinese patent application CN106176488A (control group) for 4 weeks for 10 subjects per group, and the eye complexion L of all subjects after 4 weeks was measured^*Values, scattered light brightness, comprehensive brightness ratio and spot occupancy, VISIA photographing, visual evaluation, data analysis, comparison of whether the results before and after trial of the test object are different, and statistical variation values, wherein the test results are shown in table 3 below.

TABLE 3 result of test for removing pigmentation by ultraviolet irradiation

as can be seen from the above tables 1 to 3, the examples 1 to 3 of the present invention have significant effects of removing pigmentation caused by administration of chlorpromazine, inflammation of the body and ultraviolet irradiation, and have significant effects of whitening, lightening spots and purifying skin. The comparative examples 1-3, which have no component, have a significant decrease in pigmentation caused by three factors compared with example 1, which shows that the technical effect of the invention is achieved by the combined action of the whole components. From the test results of the control group, the existing whitening composition can only aim at the pigmentation caused by a single factor, and has no obvious effect of removing the pigmentation caused by other factors.

Test example four test for repairing facial red blood streak

All the face red blood streak subjects are respectively coated with the composition for 4 weeks in examples 1-3 and comparative examples 1-3, and each group of 10 subjects are observed for the change of the face red blood streak after 4 weeks, and photographed and archived. The evaluation was performed according to the following evaluation criteria, and the evaluation results are shown in table 5 below, and the total effective rate was calculated. Total effective rate (effective + effective)/total number of cases × 100%.

TABLE 4 evaluation criteria

Item	Show effect	Is effective	Invalidation
				Changes in red blood streak	The red blood streak disappears completely	The symptoms are improved	The symptoms are not improved

TABLE 5 repair of facial Red blood streak test results

From the above table 5, it can be seen that the whitening composition disclosed in the embodiments 1-3 of the present invention has an obvious effect of removing facial red blood streak, and the total effective rate reaches 100%.

Test example five, Water content test

The skin care compositions of examples 1 to 3 of the present invention were measured for water content in each composition by a water content meter, and the results are shown in table 6 below.

TABLE 6 Water cut test results

Group of	Water content (%)
		Example 1	72％
Example 2	70％
		Example 3	65％

As can be seen from Table 6, the skin care compositions of examples 1-3 of the present invention all have a water content of 65% or more, up to 72%.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims

1. The whitening and skin-care composition capable of changing into cream is characterized by being prepared from the following components in percentage by weight: 1-20% of silicon dioxide, 1-10% of humectant, 0.1-0.8% of preservative, 120.1-5% of C12-14 alkanol polyether, 1-10% of emollient, 1-10% of skin conditioner and the balance of water;

the humectant is prepared from glycerol and butanediol in a proportion of 1: (0.5-1) by weight;

the emollient is prepared from polydimethylsiloxane and shea butter according to the weight ratio of 1: (0.1-1) by weight;

the skin conditioner comprises the following components in parts by weight: 1-10 parts of hydrolyzed yeast protein, 1-10 parts of turmeric root extract, 1-10 parts of tea extract, 1-10 parts of gentiana lutea root extract, 1-10 parts of coastal cress callus culture filtrate, 1-10 parts of sea fennel callus culture filtrate, 1-10 parts of wine extract, 1-10 parts of ganoderma lucidum extract, 1-10 parts of hydrolyzed wheat fine powder and 1-10 parts of blackberry lily root extract;

the preparation method of the whitening and skin-care composition with the powder-to-cream function comprises the following steps:

s1, heating and dissolving emollient, antiseptic and C12-14 alkanol polyether-12, and mixing to form phase A;

2. The skin care composition of claim 1 wherein the preservative is selected from at least one of methylparaben, propylparaben, and phenoxyethanol.

3. Use of the skin care composition according to claim 1 or 2 for the preparation of a skin care product for removing facial pigmentation and repairing facial red blood streaks.

4. The use according to claim 3, wherein the pigmentation comprises pigmentation caused by ultraviolet radiation, drug stimulation or an inflammatory response of the body.