CN103315934B - Composition for promoting opening of skin aquaporin and preparation method thereof - Google Patents
Composition for promoting opening of skin aquaporin and preparation method thereof Download PDFInfo
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- CN103315934B CN103315934B CN201310248241.3A CN201310248241A CN103315934B CN 103315934 B CN103315934 B CN 103315934B CN 201310248241 A CN201310248241 A CN 201310248241A CN 103315934 B CN103315934 B CN 103315934B
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Abstract
The invention particularly discloses a composition for promoting opening of skin aquaporin, which is mainly proportionally prepared from deionized water, glycerol, carbomer, xanthan gum, lycine, trehalose, inositol, taurine, lauryl mammary gland sodium lactate, monomethyl-monosilane triol, oxyproline, aspartic acid, yeast amino acid, polyglutamic acid, sodium hyaluronate, dipotassium glycyrrhetate, purslane extracting solution, licorice extract, ceramide, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary amine salt-14 and the like. The composition has the function of promoting opening of skin aquaporin, has better water replenishing and locking effect, and effectively prevents and resists the phenomena of dry skin mucosa and skin aging.
Description
Technical field
The present invention relates to promote the compositions of skin beauty water molecule transport, particularly relate to the composition and method of making the same that promotes that skin beauty water channel protein is opened.
Background technology
Horny layer is the top layer of skin, its hydration for skin appearance and physiology all tool be of great significance.Horny layer hydration determines by several factors, as ambient humidity, skin texture, Oil content and Protein content, barrier characteristics and some have material of moisturizing effect etc.Horn cell plays a decisive role to the reaction of these factors.
Aquaporin-3 (AQP3) be a kind of not only can transport of water molecule but also can transport the difunctional aquaporin of the small-molecule substances such as glycerol.In skin keratin cell, the transport of the glycerol of AQP3 mediation is of great significance for skin function tool, and its functional defect can cause that xerosis cutis, flexibility decrease and barrier action weaken etc., and skin damages.So the multiple action of AQP3 aspect skin function becomes the potential target spot of skin related disease treatment and skin-protection product development etc.
During skin aging, it is dry that skin becomes.Therefore gerontal patient, particularly in those 50 years old and above patient, to lower sebum secretion, hormone change or the current by epidermis slow down relevant axersis or the common generation of dry mucous membranes.Skin can become pruritus and tight, and this is two kinds of characteristic symptoms of dry skin.Cause the example of the acquired disease of dry skin to comprise axersis and the eczema of photochemical treatment induction.
To use the topical product that is intended to recover skin barrier for the first replacement therapy of dry skin, can be in conjunction with the wetting agent of water as used, the example comprises carbamide and the lactic acid in the Proteolytic enzyme derivant composition that enters nature moisturizing factor NMF, silk polyprotein, for keeping the film forming agent of water, maybe can rebuild the material of skin barrier, as Squalene, ceramide type, fatty acid.But these products have surface action, it does not correct defect biology of the skin of suffering from chronic dehydration.
Due to the characteristic of aquaporin, so aquaporin becomes for improving skin hydration effect and reducing potential target spot biology of xerosis cutis sign.
Aquaporin-3(AQP3) regulator is keratinocyte at the cell of the most critical of epidermis internal control controlling the water circulation shunt volume, they are just being organized below the cell of cuticular dead angle.The moisture Control of keratinocyte water channel albumen major effect cell, thus aquaporin-3rd learnt, the best aquaporin matter of skin moisture-keeping.In addition, AQP3, except control current are logical, also participates in controlling glycerol circulation, and now it is called as water-glycerol channel albumen.AQP3 is one of AQP family member, is that first is found except water is had permeability, can also penetrating glycerol and the AQP of carbamide, so AQP3 is also glycerol integrated protein at first.AQP3 is in expression and the function of skin: glycerol channel AQP3 great expression is in the horn cell of mammal skin epidermis.Mice, the main high expressed of AQP3 is in the keratinocyte basal layer of epidermis, and this confluent monolayer cells is upwards divided into cuticular layer, and forms the interface between cuticular layer and skin corium.Research to AQP3 knock-out mice skin function shows, though its epidermal structure without significant change, wettability and elasticity obviously decline, it is nearly 50% that epidermis glycerol content reduces, all there is obstacle in barrier function and injury repairing function.When or empty stomach glycerol injection oral to AQP3 knock-out mice are corrected above-mentioned all skin function obstacles completely.Thus, reach a conclusion: glycerol is the factor of determination of horny layer water conservation and biological synthetic functional, the barrier repair function after moisturizing, elasticity and the damage of the glycerol function of motion of AQP3 to skin plays critical effect.AQP3 this pivotal role in epidermis physiology can be used for developing in the dermopathic new therapy of cosmetics and the change of skin beauty water content.Aquaporin plays a significant role maintaining in body water balance and homeostasis.
But the transmission of the water of skin layer is limited upward from darker skin layer for the product of prior art.The transmission of water and glycerol must be undertaken by cell membrane, and aquaporin is responsible for this process.Be positioned at Skin Cell film aquaporin limited amount and according to the difference of skin type and skin area and difference.The effect that traditional product obtains is in most cases the short time, because conventionally can not obtain deep layer effect, and can moistening darker skin layer.Therefore, prior art lacks and can promote or actively affect the autologous product that improves hydration of horny layer.
Summary of the invention
The compositions that will provide a kind of short effectively promotion, chafe aquaporin to open is provided, thereby further makes human body skin obtain deeper moistening.
According to an aspect of the present invention, provide a kind of compositions that promotes that skin beauty water channel protein is opened, comprise by weight ratio following component:
In some embodiments, promote the compositions that skin beauty water channel protein is opened, preferably, comprise by weight ratio following component:
Another object of the present invention, is to provide a kind of method of preparing above-mentioned composition.Promote the preparation method of the compositions of skin beauty water channel protein unlatching to comprise the following steps:
(1) weigh respectively each raw material components by the weight portion proportioning of claim 1 or 2, place separately;
(2) by deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in step (1), add in reactor and mix and be heated to 80～85 DEG C, stir then evacuation 20～30 minutes, and be cooled to 75～80 DEG C, then constant temperature 25～35 minutes;
(3) mixed material in step (2) is cooled to 36～45 DEG C of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, the taurine in step (1), stir the mixture 15～25 minutes;
(4) fall to the mixed material in step (3) the lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that add successively in step (1), be uniformly mixed material 15～25 minutes;
(5) mixed material in step (4) is kept to the constant temperature 10～15 minutes of 30～35 DEG C, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in step (1), then stir 30～35 minutes, vacuum froth breaking, then discharging.
The present invention compared with prior art, its beneficial effect is: compositions of the present invention has the function that promotes that skin beauty water channel protein is opened, skin is had to profound moisturizing and moisten function, there is stronger moisturizing and lock water effect, can also effectively prevent and resist mucocutaneous dry and skin ageing phenomenon simultaneously.
Trehalose is the sugar that repeatedly stress generate in dehydration at yeast, can help cell to preserve precious moisture under xerodermatic condition.Carbamide is to keep the indispensable nature moisturizing factor composition of skin moisture, and can come off by accelerated ageing cutin.Betanin, inosite, taurine can regulate moisture flowing in cell, and especially taurine has the ability of composing skin cell alive, and can provide energy supplement to skin fast.Yeast amino acid can promote the unlatching of aquaporin-3.Polyglutamic acid has good moisture-retaining capacity.Ceramide can prevent that moisture from distributing, effectively protection and skin care.Each constituent in compositions of the present invention all can be by commercial acquisition, and jointly coordinate by a certain percentage, mutually coordinate, can promote the unlatching of skin beauty water channel protein, thereby active moisturizing composition rapid permeability is absorbed by Skin Cell to skin, improve moistening effect.
Detailed description of the invention
Embodiment 1
The present invention promotes the compositions that skin beauty water channel protein is opened, and comprises by weight ratio following component: deionized water is 53.17 parts, glycerol is 3.50 parts, carbomer is 0.02 part, xanthan gum is 0.01 part, EDETATE SODIUM is 0.02 part, allantoin is 0.05 part, carbamide is 1.00 parts, vitamin B5 is 0.20 part, betanin is 0.20 part, trehalose is 0.50 part, inosite is 0.50 part, taurine is 0.50 part, lauryl mammary gland sodium lactate is 0.20 part, monomethyl silantriol is 1.00 parts, hydroxyproline is 1.00 parts, aspartic acid is 1.00 parts, yeast amino acid is 0.50 part, polyglutamic acid is 0.01 part, hyaluronate sodium is 0.01 part, glycyrrhizic acid dipotassium is 0.01 part, Herba Portulacae extract is 1.50 parts, Radix Glycyrrhizae extract is 1.30 parts, ceramide 3 is 0.001 part, Cer AP is 0.001 part, Cer EOS is 0.001 part, phytosphingosine is 0.05 part, cholesterol is 0.10 part, oligopeptide-1 is 0.001 part, polyquaternary ammonium salt-14 are 0.05 part.(above raw material is commercially available)
Concrete preparation method and step are as follows:
(1) weigh respectively each raw material components by said components and weight portion proportioning, place separately;
(2) by deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in step (1), add in reactor and mix and be heated to 80 DEG C, stir then evacuation, and be cooled to 75 DEG C, then constant temperature 25 minutes 20 minutes;
(3) mixed material in step (2) is cooled to 36 DEG C of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, the taurine in step (1), 15 minutes and constant temperature 15 minutes stir the mixture;
(4) fall to the mixed material in step (3) the lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that add successively in step (1), be uniformly mixed material 15 minutes;
(5) mixed material in step (4) is kept to the constant temperature 10 minutes of 30 DEG C, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in step (1), then stir 30 minutes, vacuum froth breaking, then discharging.
Embodiment 2
The present invention promotes the compositions that skin beauty water channel protein is opened, comprise by weight ratio following component: deionized water is 76.67 parts, glycerol is 4.50 parts, carbomer is 0.04 part, xanthan gum is 0.04 part, EDETATE SODIUM is 0.10 part, allantoin is 0.20 part, carbamide is 5.00 parts, vitamin B5 is 1.00 parts, betanin is 2.00 parts, trehalose is 2.00 parts, inosite is 1.50 parts, taurine is 1.00 parts, lauryl mammary gland sodium lactate is 0.40 part, monomethyl silantriol is 2.00 parts, hydroxyproline is 3.00 parts, aspartic acid is 2.00 parts, yeast amino acid is 4.00 parts, polyglutamic acid is 0.10 part, hyaluronate sodium is 0.10 part, glycyrrhizic acid dipotassium is 0.40 part, Herba Portulacae extract is 5.50 parts, Radix Glycyrrhizae extract is 2.30 parts, ceramide 3 is 0.01 part, Cer AP is 0.02 part, Cer EOS is 0.02 part, phytosphingosine is 0.12 part, cholesterol is 0.30 part, oligopeptide-1 is 0.08 part, polyquaternary ammonium salt-14 are 0.10 part.
Concrete preparation method and step are as follows:
(1) weigh respectively each raw material components by said components and weight portion proportioning, place separately;
(2) by deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in step (1), add in reactor and mix and be heated to 85 DEG C, stir then evacuation, and be cooled to 80 DEG C, then constant temperature 35 minutes 30 minutes;
(3) mixed material in step (2) is cooled to 45 DEG C of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, the taurine in step (1), 25 minutes and constant temperature 20 minutes stir the mixture;
(4) fall to the mixed material in step (3) the lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that add successively in step (1), be uniformly mixed material 25 minutes;
(5) mixed material in step (4) is kept to the constant temperature 15 minutes of 35 DEG C, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in step (1), then stir 35 minutes, vacuum froth breaking, then discharging.
Embodiment 3
The present invention promotes the compositions that skin beauty water channel protein is opened, comprise by weight ratio following component: deionized water is 60 parts, glycerol is 4.00 parts, carbomer is 0.03 part, xanthan gum is 0.03 part, EDETATE SODIUM is 0.05 part, allantoin is 0.10 part, carbamide is 2.00 parts, vitamin B5 is 0.50 part, betanin is 1.00 parts, trehalose is 1.00 parts, inosite is 0.80 part, taurine is 0.80 part, lauryl mammary gland sodium lactate is 0.30 part, monomethyl silantriol is 1.50 parts, hydroxyproline is 1.50 parts, aspartic acid is 1.50 parts, yeast amino acid is 2.50 parts, polyglutamic acid is 0.05 part, hyaluronate sodium is 0.05 part, glycyrrhizic acid dipotassium is 0.10 part, Herba Portulacae extract is 2.50 parts, Radix Glycyrrhizae extract is 1.50 parts, ceramide 3 is 0.008 part, Cer AP is 0.008 part, Cer EOS is 0.008 part, phytosphingosine is 0.08 part, cholesterol is 0.20 part, oligopeptide-1 is 0.03 part, polyquaternary ammonium salt-14 are 0.08 part.
Concrete preparation method and step are as follows:
(1) weigh respectively each raw material components by said components and weight portion proportioning, place separately;
(2) by deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in step (1), add in reactor and mix and be heated to 83 DEG C, stir then evacuation, and be cooled to 78 DEG C, then constant temperature 30 minutes 27 minutes;
(3) mixed material in step (2) is cooled to 40 DEG C of backward its and adds successively carbamide, vitamin B5, carbamide, vitamin B5, betanin, trehalose, inosite, the taurine in step (1), 20 minutes and constant temperature 18 minutes stir the mixture;
(4) fall to the mixed material in step (3) the lauryl mammary gland sodium lactate, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid that add successively in step (1), be uniformly mixed material 20 minutes;
(5) mixed material in step (4) is kept to the constant temperature 13 minutes of 32 DEG C, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in step (1), then stir 33 minutes, vacuum froth breaking, then discharging.
The effect experiment of the present composition
(1) compositions of getting the embodiment of the present invention 3 is carried out effect mensuration, and concrete assay method and measurement result are specific as follows:
To produce the compositions obtaining as example according to embodiment 3, and adopt matched group (this matched group be two groups, the product that wherein matched group one uses is normal saline, the product that matched group two uses is glycerol) carry out the actual use of crowd tracking test, to investigate the result of use of elimination eczema of compositions of the present invention.In this experiment, choose 300 volunteers, 50～60 years old age, on arm, there is respectively eczema in various degree, volunteer is divided into three groups of (experimental group, matched group one and matched group two) every group of 100 people at random, experimental group is coated with and uses compositions of the present invention, matched group one painting normal saline, matched group two painting glycerol.Every day, sooner or later respectively once the evaluation result of after 45 days, eczema being improved to effect recorded as shown in table 1.
Table 1-eczema is improved the evaluation result of effect
The structure recording from table 1, compositions of the present invention has better therapeutic effect to the acquired disease-eczema of dry skin.Wherein effectively refer to that compositions of the present invention can cure eczema, effectively refer to that compositions of the present invention has to eczema degree the effect of alleviating.
(2) prove the impact that compositions of the present invention is expressed the aquaporin 3 in skin samples, get the combination of embodiment 3 and measure, concrete assay method and result are as follows:
Cultivate application on human skin sample at gas/liquid interface.Experimental group is the application on human skin sample of the compositions of local application embodiment 3, and matched group one is untreated application on human skin sample, the application on human skin sample that matched group two is local application glycerol.All samples is all hatched 48 hours.Then fix after these skin samples with formaldehyde, be embedded in afterwards in paraffin, then obtain the section of 4～5 microns.In multiple washings with carry out immune labeled after hatching the step of these sections.By aquaporin 3 specific antibodies, then be coupling agent fluorescently-labeled two anti-carry out immune labeled, then use Epi-fluorescence microscope (Nikon Eclipse E600 microscope) to check described skin biopsy, its epidermis is as shown in table 2 compared with upper strata fluorescent effect grade.
Table 2-epidermis is compared with upper strata fluorescent effect grade
| ? | Experimental group | Matched group one | Matched group two |
| Fluorescent effect | By force | Generally | Generally |
As shown in Table 2, the compositions of experimental group promotes the expression of aquaporin 3 strongly, particularly shows peridermal expression.
(3) human body uses the test of the moisture after the present composition, and concrete method of testing and result are as follows:
Taking the compositions of embodiment 3 as example, and adopt matched group to carry out the actual use of crowd tracking test, matched group does not carry out any moisturizing processing.In this experiment, choose 30 volunteers, the concrete age is determined at random.Volunteer's left hand arm position is coated with and uses compositions of the present invention, and right arm does not use any product to process as blank group.Start to measure with cutin drimeter the water content base value of Experimental Area in experiment, experiment starts after 20 minutes, 5 hours, 10 hours and 24 hours, measure respectively again the moisture content of skin 5 times of different time sections with identical gauge, average, statistics volunteer tests the numerical value that position records at every turn, the moisture increment of analyzing skin.
The moisture increment of table 3-skin
| ? | 20 minutes | 5 hours | 10 hours | 24 hours |
| The moisture increment of experimental group | 40% | 36% | 29% | 23% |
| The moisture increment of matched group | 1.2% | 6% | 4% | 2.2% |
As known from Table 3, compositions of the present invention can keep the skin wet to skin at short notice quickly, and lock water function is better, can allow skin realize the long-acting moisturizing of whole day.
Above-described is only some embodiments of the present invention.For the person of ordinary skill of the art, without departing from the concept of the premise of the invention, can also make some distortion and improvement, these all belong to the protection domain of invention.
Claims (3)
1. promote the compositions that skin beauty water channel protein is opened, it is characterized in that, comprise by weight ratio following component:
2. the compositions that promotion skin beauty water channel protein according to claim 1 is opened, is characterized in that, comprises by weight ratio following component:
3. the preparation method of the compositions that the promotion skin beauty water channel protein described in claim 1 or 2 is opened, is characterized in that, comprises the following steps:
(1) weigh respectively each raw material components by the weight portion proportioning of claim 1 or 2, place separately;
(2) by deionized water, glycerol, carbomer, xanthan gum, EDETATE SODIUM and allantoin in step (1), add in reactor and mix and be heated to 80～85 DEG C, stir then evacuation 20～30 minutes, and be cooled to 75～80 DEG C, then constant temperature 25～35 minutes;
(3) mixed material in step (2) is cooled to 36～45 DEG C of backward its and adds successively carbamide, vitamin B5, betanin, trehalose, inosite, the taurine in step (1), stir the mixture 15～25 minutes;
(4) in the mixed material in step (3), add successively lauroyl dilactic acid sodium, monomethyl silantriol, hydroxyproline, aspartic acid, yeast amino acid, the polyglutamic acid in step (1), be uniformly mixed material 15～25 minutes;
(5) mixed material in step (4) is kept to the constant temperature 10～15 minutes of 30～35 DEG C, add successively again hyaluronate sodium, glycyrrhizic acid dipotassium, Herba Portulacae extract, Radix Glycyrrhizae extract, ceramide 3, Cer AP, Cer EOS, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary ammonium salt-14 in step (1), then stir 30～35 minutes and carry out vacuum froth breaking.
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| CN108619007A (en) * | 2018-06-29 | 2018-10-09 | 广西浙缘农业科技有限公司 | A kind of face cream containing camellia seed oil |
| CN111297725A (en) * | 2018-12-11 | 2020-06-19 | 安琪酵母股份有限公司 | Skin care composition for restoring skin barrier function and preparation method and application thereof |
| JP7356826B2 (en) * | 2019-06-25 | 2023-10-05 | 小林製薬株式会社 | External composition |
| CN111419751A (en) * | 2020-04-23 | 2020-07-17 | 广州市科能化妆品科研有限公司 | Soothing composition, preparation method thereof and skin care product containing soothing composition |
| CN114886811A (en) * | 2022-05-25 | 2022-08-12 | 广州澳莱娜生物科技有限公司 | Composition for repairing sensitive skin |
| EP4356898A1 (en) * | 2022-10-20 | 2024-04-24 | Croda Korea Limited | Cosmetic composition comprising ceramides and sphingolipid |
Family Cites Families (3)
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| FR2944526B1 (en) * | 2009-04-15 | 2013-05-10 | Isp Investments Inc | COSMETIC AND / OR PHARMACEUTICAL COMPOSITION COMPRISING A PEPTIDE HYDROLYZATE CAPABLE OF STRENGTHENING BARRIER FUNCTION |
| CN102357070B (en) * | 2011-11-10 | 2013-05-01 | 深圳市金因生物技术有限公司 | Hydrolyzed silk protein/ recombinant human Epidermal Growth Factor (rhEGF) compound skin care facial mask and preparation method thereof |
| CN102579297B (en) * | 2012-03-16 | 2013-05-01 | 深圳市金因生物技术有限公司 | Cosmetic for improving tolerance of skin and preparation method thereof |
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