CN103520081B - The external use skin care of a kind of regulation of skin immunity, delay skin aging - Google Patents
The external use skin care of a kind of regulation of skin immunity, delay skin aging Download PDFInfo
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- CN103520081B CN103520081B CN201310449238.8A CN201310449238A CN103520081B CN 103520081 B CN103520081 B CN 103520081B CN 201310449238 A CN201310449238 A CN 201310449238A CN 103520081 B CN103520081 B CN 103520081B
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Abstract
The invention discloses a kind of regulation of skin immunity, the external use skin care of delay skin aging, it is characterized in that, by powder, water preparation and Emulsion composition, wherein, described powder comprises oligopeptide-1 and ginsenoside, described water preparation comprises Glycyrrhiza glabra L. root extract, Herba Artemisiae Scopariae flower extract, Radix Mori extract, Fructus Jujubae berry extract, scutellariae,radix extract, hydrolysis rice gluten and nicotiamide, described Emulsion comprises two and splits the molten spore thing of culture propagation product, creatine, carnosine, glucityl Hesperidin, six peptides-3, Herba Centellae extract, coenzyme Q10 wrappage, Prunus persica f. compressa Cactus Pedicel extract, Radix Rhodiolae extract, Herba Saussureae Involueratae extract, Radix Notoginseng extract and Radix Angelicae Sinensis extract wrappage.Powder of the present invention, water preparation and Emulsion three share, and have and reduce wrinkle, minimizing skin coarseness, and even skin tone, raising skin elasticity, firm skin, make skin finer and smoother, more aobvious youth.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of regulation of skin immunity, the external use skin care of delay skin aging.
Background technology
Skin aging is a part for human senescence, and it is both relevant with age factor, closely related with sun exposure again.Skin photoage is primarily of caused by sun exposure, and along with current depletion of the ozone layer increases the weight of, skin photoage phenomenon is more and more serious, and it not only impairs the beauty treatment of people, also with skin carcinoma have etiologic etiological relation.Sun exposure also can cause Langerhans cell quantity reduce and weaken its function, and light immunity atrophy causes damaged cell to accumulate, and just can cause skin aging for a long time.
Containing many active component in Chinese medicine extract, as saponin, flavone, alkaloid isoreactivity composition, different active component has different skin-protecting functions.Chinese herbal medicine beauty and skin care has the history of several thousand, particularly people in China to have started to abandon synthetics now, advocates natural materials.Therefore, Chinese herbal medicine beauty treatment receives the welcome of people.
Summary of the invention
The object of this invention is to provide a kind of external use skin care with immunity moderation power, delay skin aging.
Object of the present invention is achieved by the following technical programs: the external use skin care of a kind of regulation of skin immunity, delay skin aging, is made up of powder, water preparation and Emulsion, wherein,
Described powder comprises the component of following weight portion:
Oligopeptide-1 0 ~ 1.0 part
Ginsengenin 20 ~ 5.0 part
The weight portion of said components is zero time different;
Described water preparation comprises the component of following weight portion:
Glycyrrhiza glabra L. root extract 0 ~ 3.0 part
Herba Artemisiae Scopariae flower extract 0 ~ 3.0 part
Radix Mori extract 0 ~ 2.0 part
Fructus Jujubae berry extract 0 ~ 2.0 part
Scutellariae,radix extract 0 ~ 2.0 part
Hydrolysis rice gluten 0 ~ 5.0 part
Nicotiamide 0 ~ 3.0 part
The weight portion of said components is zero time different;
Described Emulsion comprises the component of following weight portion:
Two split the molten spore thing of culture propagation product 0.5 ~ 10.0 part
Creatine 0 ~ 2.0 part
Carnosine 0 ~ 2.0 part
Glucityl Hesperidin 0 ~ 5.0 part
Six peptides-3 0 ~ 5.0 parts
Herba Centellae extract 0 ~ 3.0 part
Coenzyme Q10 wrappage 0 ~ 2.0 part
Prunus persica f. compressa Cactus Pedicel extract 0 ~ 5.0 part
Radix Rhodiolae extract 0 ~ 2.0 part
Herba Saussureae Involueratae extract 0 ~ 5.0 part
Radix Notoginseng extract 0 ~ 5.0 part
Radix Angelicae Sinensis extract wrappage 0 ~ 5.0 part
Said components is removed two and is split the molten spore beyond the region of objective existence of culture propagation product, is zero when the weight portion of all the other components is different.
In described powder, oligopeptide-1 is epidermal growth factor, is microorganism high density secretion through highly purified albumen, it has the biological effect promoting skin epidermal cells growth metabolism under high-tech condition.Ginsenoside can be the total saponins be processed into through extraction from the root of Araliaceae Radix Ginseng Panax ginseng C.A .Mey., also can be the mixing of arbitrary monomer ginsenoside or various of monomer ginsenoside, as the mixing of one or both in ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Rg3 and Rh2.
In described water preparation; hydrolysis rice gluten refers to zymolyte rice protein alkaline protease and compound protease cohydrolysis obtained; it has Thymopentin; the Langerhans cell atrophy that UV causes can be prevented; the skin texture preventing UV from causing and integrity change; protection skin texture and integrity thereof; increase β 1-integrin, keratin and the synthesis of silk polyprotein; thus it is active to strengthen skin immunization; Human keratinocytes's culture experiment proves, hydrolysis rice gluten has raising cell viability and reaches 34%.
Glycyrrhiza glabra L. root extract has osajin composition-glabridin Glabridin, and its chemical constitution has isoflavone parent nucleus, and A ring and B ring are aromatic ring, B ring has 2 phenolic hydroxyl groups, there is individual ethylene linkage C9-position, therefore have stronger antioxidant activity.Radix Rhodiolae has fabulous immunoregulation effect, has protective effect to the apoptosis of fibroblasts that ultraviolet causes, delaying skin photoaging effect.
Emulsion of the present invention is emulsion, gel or cream.Wherein, two to split the molten spore thing of culture propagation product be the bacillus bifidus lysate utilizing biotechnology to obtain, and comprises metabolite, endochylema component, cell-wall component and polysaccharides compound.Research finds ultraviolet radiation meeting, and IL-12 secretion reduces the propagation affecting NK cell and T cell, and IL-10 expresses increase and causes immunosuppressant, thus DNA is suffered damage.Experiment proof two is split the IL-10 that the molten spore thing of culture propagation product can cause ultraviolet light and is expressed the immunosuppressant increasing and cause, and can excited ultraviolet irradiate after skin DNA naturally repair substrate, delaying skin is because the ager process that causes of ultraviolet light.
Creatine can increase the storage power of cell thus increase spendable ATP, and promotes the reparation of DNA and promote that cell synthesizes by the DNA after ultraviolet radiation infringement, obviously reduces the sunburn of cell by induced by ultraviolet irradiation, delay skin aging process.
Carnosine, also claims dipeptides or β-propylamine acyl group-L-Histidine, have scavenging capacity free radical, antioxidation, anti-glycosylation, anti-protein-crosslinking, sequester heavy metal ions, delay the effect of the process that telomere shortens, thus delaying skin is aging.
Hesperidin is a kind of natural biological flavonoid from Orange Peel, is described as " Citrin ", has the resistance strengthening capillary tube, reduces permeability and antiinflammatory action.Glucityl Hesperidin is a kind of derivant of water solublity hesperidin, utilizes zymotechnic to combine, and improves water dissolution performance.Experiment proves that glucityl Hesperidin has enhancing blood circulation, improves skin color, promotes effect of skin brightness.
Six peptides-3 are the allied substances of the 6-aminoacid sequence appeared in fibronectin molecule III type unit.Experiment proof six peptide-3 can improve cytoadherence effect, improves the expression of integrin β 1, helps cell more homogeneous sprawling on collagen protein, contributes to preventing skin photoage.
Herba Centellae extract contains Herba Centellae total glycosides and asiaticoside active component, has promotion proliferation of human dermal fibroblasts, promotes the effect of collage synthesis, inflammation-inhibiting.Herba Centellae extract can promote that ageing skin skin regenerates, and promote effect of wound healing, coenzyme Q10 is antioxidant, is the activator of Cellular respiration and metabolism, can bring energy and vigor to body and skin, and can active oxygen in purged body.Skin is subject to outside or inside when affecting, and is inflamed in course of reaction, produces a large amount of free radical, and coenzyme Q10 can scavenging free radicals, delay skin aging.Experiment proves, Prunus persica f. compressa Cactus Pedicel extract is by improving cathepsin-D, horny layer Chymotrypsin (SCCE) and horny layer trypsin SCTE) activity, promote coming off of horn cell, accelerate cell turnover, improve skin transparency and glossiness, reduce microgroove and wrinkle.
Herba Saussureae Involueratae extract is containing polysaccharide and flavonoid active ingredient, there are promotion and immunity moderation function, anti-radical action, and can jointly form the outer gelatinised matrix of born of the same parents of large quantity of moisture with other polysaccharide components of skin and fibrous proteins, for skin provides moisture, the problem of aging such as delaying skin appearance is dry, follow the string.
The active component of Radix Notoginseng is Radix Notoginseng total arasaponins, to raising skin SOD vigor, reduces hydroxyproline content effect in MDA content and raising skin obvious.
When being classified as the dry root of umbelliferae angelica, there is the ability of scavenging free radicals, complexation ferrous ion ability and restraint of tyrosinase, to skin aging and whitening all powerful.Mainly comprising of angelica root is volatile oil and fixed oil composition, and abnormal smells from the patient is heavier, reduces abnormal smells from the patient by parcel, makes active component be easy to infiltration simultaneously.
Described coenzyme Q10 wrappage refers to and uses conventional liposome technology to wrap up coenzyme Q10.
Further, the weight portion of described powder component is:
Oligopeptide-1 0.01 ~ 0. 5 part
Ginsenoside 0.1 ~ 2.0 part.
Further, the weight portion of described powder component is:
Oligopeptide-1 0.01 ~ 0.05 part
Ginsenoside 0.10 ~ 0.50 part.
Further, the weight portion of described water preparation component is:
Glycyrrhiza glabra L. root extract 0.10 ~ 1.50 part
Herba Artemisiae Scopariae flower extract 0.10 ~ 1.50 part
Radix Mori extract 0.10 ~ 1.00 part
Fructus Jujubae berry extract 0.10 ~ 1.00 part
Scutellariae,radix extract 0.10 ~ 1.00 part
Hydrolysis rice gluten 0.10 ~ 2.00 part
Nicotiamide 0.10 ~ 1.50 part.
Further, the weight portion of described water preparation component is:
Glycyrrhiza glabra L. root extract 0.5 ~ 1.0 part
Herba Artemisiae Scopariae flower extract 0.5 ~ 1.0 part
Radix Mori extract 0.5 ~ 1.0 part
Fructus Jujubae berry extract 0.5 ~ 1.0 part
Scutellariae,radix extract 0.5 ~ 1.0 part
Hydrolysis rice gluten 0.5 ~ 1.0 part
Nicotiamide 0.50 ~ 1.0 part.
Further, the weight portion of described Emulsion component is:
Radix Rhodiolae extract 0.1 ~ 2.0 part
Two split the molten spore thing of culture propagation product 0.5 ~ 5.0 part
Creatine 0.5 ~ 1.5 part
Carnosine 0.1 ~ 1.0 part
Glucityl Hesperidin 0.1 ~ 2.0 part
Six peptides-3 0.5 ~ 1.5 parts
Herba Centellae extract 0.1 ~ 1.0 part
Coenzyme Q10 wrappage 0.1 ~ 1.0 part
Prunus persica f. compressa Cactus Pedicel extract 0.1 ~ 3.0 part.
Powder provided by the invention, water preparation and Emulsion, except above-mentioned principle active component, also comprise the conventional substrate of cosmetics exterior-applied formulation.Wherein, the conventional substrate in powder comprises the adjuvants such as mannitol, sodium hydrogen phosphate and sodium dihydrogen phosphate.Conventional substrate in water preparation comprises the adjuvants such as hyaluronate sodium, gelatinum oxhide, butanediol, EDETATE SODIUM, glycyrrhizic acid dipotassium, pantothenylol, antiseptic.In Emulsion, conventional substrate comprises bisabolol, N-palmityl hydroxyproline cetyl, campesterol, Jojoba seed oil, plant sterol isostearate, Vitamin E acetate, silicone oil, cetearyl alcohol, Sucrose Polystearic Acid Esters, behenyl alcohol polyethers-25, dipalmitoyl hydroxyproline, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, butanediol, glycerol, stearoyl-glutamic acid sodium, EDETATE SODIUM, xanthan gum, deionized water, acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20, 1-methyl hydantoin-2-acid imide, the adjuvants such as antiseptic.
the present invention has following beneficial effect:
(1) powder of the present invention has the effect of immunity moderation power, delay skin aging, and water preparation has immunity moderation power, skin whitening, effect of delay skin aging, and Emulsion has immunity moderation power, firm skin, effect of delay skin aging.Three share, and 28 days is one-period, has and reduces wrinkle, minimizing skin coarseness, and even skin tone, raising skin elasticity, firm skin, make skin finer and smoother, more aobvious youth.
(2) onset time of the present invention is short, and only needs intermittent use, as 3 months use 28 days (one-period), or uses when dermal sensation is bad.
(3) preparation technology of powder of the present invention, water preparation and Emulsion can ensure that active component can not run off in storage process, guarantees functional effect.
Accompanying drawing explanation
Fig. 1 is that the skin care item of the embodiment of the present invention 1 and the skin care item of comparative example 1 improve general effect satisfaction bar shaped comparison diagram to skin;
Fig. 2 is that the skin care item of the embodiment of the present invention 1 and the skin care item of comparative example 1 improve general effect bar shaped comparison diagram to skin;
Fig. 3 is that the skin care item of the embodiment of the present invention 1 and the skin care item of comparative example 1 improve weekly effect curve comparison diagram to skin.
Detailed description of the invention
Explain the present invention further below in conjunction with specific embodiment, but embodiment does not limit in any form to the present invention.The raw material components used in the embodiment of the present invention belongs to commercial goods, all can commercially obtain.Unless otherwise specified, the number of each component is weight portion otherwise in following examples.
embodiment 1
1. the preparation of powder
The component of powder is:
Oligopeptide-1 0.1 part
Ginsenoside 1.0 parts
10.0 parts, mannitol
Sodium hydrogen phosphate 0.5 part
Sodium dihydrogen phosphate 0.2 part
The preparation method of powder is:
(1) be dissolved in by all components in appropriate deionized water, gained solution adopts 0.2 micron membranes to filter.
(2) be divided in vial, put into vacuum freezing drying oven.
(3) through 45 hours vacuum freezings, drying is powdery, and capping, to obtain final product.
2. the preparation of water preparation
The component of water preparation is:
Glycyrrhiza glabra L. root extract 2.0 parts
Herba Artemisiae Scopariae flower extract 2.0 parts
Radix Mori extract 1.0 parts
Fructus Jujubae berry extract 1.0 parts
Scutellariae,radix extract 1.0 parts
Hydrolysis rice gluten 3.0 parts
Nicotiamide 2.0 parts
Hyaluronate sodium 0.5 part
Butanediol 10.0 parts
EDETATE SODIUM 0.5 part
Glycyrrhizic acid dipotassium 1.0 parts
Pantothenylol 5.0 parts
Antiseptic 0.1 part
Deionized water is appropriate
The molecular weight 300,000 of above-mentioned hyaluronate sodium.
The preparation method of water preparation is:
(1) hyaluronate sodium is added in deionized water, stirring and dissolving;
(2) all the other components are added, stirring and dissolving;
(3) adjust ph to 5.5 ~ 7.0 obtain water preparation, and inspection, after qualified, then carry out fill and get final product.
3. the preparation of emulsion
The component of emulsion is:
A phase:
Jojoba seed oil 8 parts
Plant sterol isostearate 5 parts
Vitamin E acetate 3 parts
Radix Rhodiolae extract 0.1 part
Palmityl hydrolyzed wheat protein 3 parts
Cetearyl alcohol 2 parts
Sucrose Polystearic Acid Esters 2 parts
Parleam 5 parts
Dipalmitoyl hydroxyproline 2 parts
B phase: acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.5 part
Butanediol 10 parts
Glycerol 5 parts
1 part, stearoyl-glutamic acid sodium
EDETATE SODIUM 0.1 part
Xanthan gum 0.5 part
Deionized water surplus;
C phase: acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20 2.0 parts
D phase: aminomethyl propanol 0.2 part
1-methyl hydantoin-2-acid imide 1.0 parts
Creatine 0.5 part
Carnosine 0.5 part
Glucityl Hesperidin 1.0 parts
Glycyrrhizic acid dipotassium 2.0 parts
Two split the molten spore thing of culture propagation product 5.0 parts
Six peptides-3 0.5 parts
Herba Centellae extract 1.0 parts
Coenzyme Q10 wrappage 1.0 parts
Prunus persica f. compressa Cactus Pedicel extract 2.0 parts
Herba Saussureae Involueratae extract 0.5 part
Radix Notoginseng extract 0.5 part
Radix Angelicae Sinensis extract wrappage 0.5 part
Antiseptic 0.1 part
The preparation method of emulsion is:
(1) by A phase all components mix homogeneously, be heated to 80 DEG C, stir and make it dissolve, obtain A phase solution;
(2) by acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer adds in deionized water, after stirring and dissolving, add other raw materials of B phase, be heated to 80 DEG C, stir and make it dissolve, obtain B phase solution;
(3) A phase solution is added in B phase solution, and add C phase all components, stir emulsifying;
(4) stirring is cooled to 45 DEG C, adds aminomethyl propanol, after stirring and dissolving, adds all the other components of D phase, stirs and is cooled to 30 ~ 35 DEG C;
(5) regulate between pH value to 5.5 ~ 6.5, obtain emulsion, inspection, after qualified, then carry out fill and get final product.
embodiment 2
1. the preparation of powder
The component of powder is:
Oligopeptide-1 0.5 part
Ginsenoside 2.0 parts
15 parts, mannitol
Sodium hydrogen phosphate 0.5 part
Sodium dihydrogen phosphate 0.2g part
The preparation method of powder is:
(1) be dissolved in by all the components in appropriate deionized water, gained solution is by 0.2 Mm filter.
(2) be placed in loading tray, put into vacuum freezing drying oven.
(3) through 45 hours vacuum freezings, drying is powdery, is packed as bottle, obtains final product.
2. the preparation of water preparation
The component of water preparation is:
Glycyrrhiza glabra L. root extract 0.5 part
Herba Artemisiae Scopariae flower extract 0.5 part
Radix Mori extract 0.5 part
Fructus Jujubae berry extract 0.5 part
Scutellariae,radix extract 0.5 part
Hydrolysis rice gluten 1.0 parts
Hyaluronate sodium 0.5 part
Butanediol 8.0 parts
EDETATE SODIUM 0.1 part
Glycyrrhizic acid dipotassium 0.5 part
Pantothenylol 0.5 part
Nicotiamide 0.3 part
Xanthan gum 1.2 parts
Antiseptic 0.1 part
Deionized water is appropriate
The molecular weight 300,000 of above-mentioned hyaluronate sodium.
The preparation method of water preparation is:
(1) xanthan gum is added in deionized water, stirring and dissolving;
(2) other all the components are added in (1), stirring and dissolving;
Regulate between pH value to 5.5 ~ 6.5, obtain water preparation, inspection, after qualified, then carry out fill and get final product.
3. the preparation of emulsion
The component of described emulsion is:
A phase:
Jojoba seed oil 5 parts
Plant sterol isostearate 2 parts
Vitamin E acetate 5 parts
Radix Rhodiolae extract 0.5 part
Cetearyl alcohol 3 parts
Sucrose Polystearic Acid Esters 5 parts
Dipalmitoyl hydroxyproline 2 parts
B phase: acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 1.5 parts
Butanediol 15 parts
Glycerol 15 parts
0.5 part, stearoyl-glutamic acid sodium
EDETATE SODIUM 0.1 part
Xanthan gum 0.5 part
Deionized water surplus
C phase: acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20 2.0 parts
D phase: aminomethyl propanol 0.15 part
1-methyl hydantoin-2-acid imide 1.0 parts
Creatine 0.5 part
Carnosine 0.5 part
Glucityl Hesperidin 1.0 parts
Glycyrrhizic acid dipotassium 2.0 parts
Two split the molten spore thing of culture propagation product 5.0 parts
Six peptides-3 1.0 parts
Herba Centellae extract 1.0 parts
Coenzyme Q10 wrappage 1.0 parts
Prunus persica f. compressa Cactus Pedicel extract 2.0 parts
Herba Saussureae Involueratae extract 0.5 part
Radix Notoginseng extract 0.5 part
Radix Angelicae Sinensis extract wrappage 0.5 part
Antiseptic 0.1 part
The preparation method of cream is:
(1) by A phase heating raw materials to 80 ~ 90 DEG C, stir and make it dissolve;
(2) by acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer adds in deionized water, after stirring and dissolving, add other raw materials of B phase, be heated to 80 ~ 90 DEG C, stir and make it dissolve;
(3) A is added in B phase, stirs emulsifying, add C phase raw material simultaneously.
(4) mix and be cooled to 45 DEG C, add aminomethyl propanol, after stirring and dissolving, add other raw materials of D phase, stir and be cooled to 30 ~ 35 DEG C.
(5) regulate between pH value to 5.5 ~ 7.0, obtain cream;
(6) above-mentioned cream is tested, after qualified, then carry out fill and get final product.
embodiment 3
1. the preparation of powder
The raw material components of powder is:
Oligopeptide-1 0.5 part
Ginsenoside 2.0 parts
Mannitol surplus
The preparation method of powder is:
(1) by all the components mix homogeneously.
(2) be divided in fractional pack.
2. the preparation of water preparation
The raw material components of water preparation is:
Glycyrrhiza glabra L. root extract 2.0 parts
Herba Artemisiae Scopariae flower extract 2.0 parts
Radix Mori extract 1.0 parts
Fructus Jujubae berry extract 1.0 parts
Scutellariae,radix extract 1.0 parts
Hydrolysis rice gluten 3.0 parts
Glycerol 10.0 parts
EDETATE SODIUM 0.1 part
Glycyrrhizic acid dipotassium 2.0 parts
Pantothenylol 0.5 part
Nicotiamide 1.0 parts
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 1.0 parts
Aminomethyl propanol 0.15 part
Antiseptic 0.10 part
Deionized water is appropriate
The molecular weight 300,000 of above-mentioned hyaluronate sodium.
The preparation method of water preparation is:
(1) by acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer adds in deionized water, dispersed with stirring, adds aminomethyl propanol, is stirred to and dissolves completely;
(2) other all the components are added in (1), stirring and dissolving;
(3) regulate between pH value to 5.5 ~ 7.0;
Above-mentioned water preparation is tested, after qualified, then carry out fill and get final product.
3. the preparation of gel
Gel material component is:
A phase:
Cetearyl alcohol 2 parts
Sucrose Polystearic Acid Esters 2 parts
Dipalmitoyl hydroxyproline 2 parts
Radix Rhodiolae extract 0.1 part
B phase: acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 3 parts
Butanediol 10 parts
Glycerol 5 parts
EDETATE SODIUM 0.1 part
Xanthan gum 0.5 part
Deionized water surplus
C phase: acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20 2.0 parts
D phase: aminomethyl propanol 0.3 part
Creatine 0.5 part
Carnosine 0.5 part
Glucityl Hesperidin 1.0 parts
Glycyrrhizic acid dipotassium 2.0 parts
Two split the molten spore thing of culture propagation product 5.0 parts
Six peptides-3 0.5 parts
Herba Centellae extract 1.0 parts
Coenzyme Q10 wrappage 1.0 parts
Prunus persica f. compressa Cactus Pedicel extract 2.0 parts
Herba Saussureae Involueratae extract 0.5 part
Radix Notoginseng extract 0.5 part
Radix Angelicae Sinensis extract wrappage 0.5 part
Antiseptic 0.1 part
The preparation method of gel is:
(1) by A phase heating raw materials to 80 ~ 90 DEG C, stir and make it dissolve;
(2) by acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer adds in deionized water, after stirring and dissolving, add other raw materials of B phase, be heated to 80 ~ 90 DEG C, stir and make it dissolve;
(3) A is added in B phase, stirs emulsifying, add C phase raw material simultaneously.
(4) mix and be cooled to 45 DEG C, add aminomethyl propanol, after stirring and dissolving, add other raw materials of D phase, stir and be cooled to 30 ~ 35 DEG C.
(5) regulate between pH value to 5.5 ~ 7.0 and obtain gel;
(6) above-mentioned gel is tested, after qualified, then carry out fill and get final product.
embodiment 4
1. the preparation of powder
The component of powder is:
Oligopeptide-1 0.001 part
Ginsenoside 0.1 part
5.0 parts, mannitol
Sodium hydrogen phosphate 0.5 part
Sodium dihydrogen phosphate 0.2 part
The preparation method of powder is:
(2) all components is dissolved in appropriate deionized water, gained solution pressure cooker 121 DEG C, 0.1Mpa sterilizing 30mins.
(2) be divided in vial, put into vacuum freezing drying oven.
(3) through 45 hours vacuum freezings, drying is powdery, and capping, to obtain final product.
2. the preparation of water preparation
The component of water preparation is:
Glycyrrhiza glabra L. root extract 0.5 part
Herba Artemisiae Scopariae flower extract 0.5 part
Radix Mori extract 0.3 part
Fructus Jujubae berry extract 0.3 part
Scutellariae,radix extract 0.3 part
Hydrolysis rice gluten 1.0 parts
Nicotiamide 0.5 part
Hyaluronate sodium 0.1 part
Butanediol 8.0 parts
EDETATE SODIUM 0.1 part
Glycyrrhizic acid dipotassium 0.1 part
Pantothenylol 0.5 part
Antiseptic 0.01 part
Deionized water is appropriate
The molecular weight 300,000 of above-mentioned hyaluronate sodium.
The preparation method of water preparation is:
(3) hyaluronate sodium is added in deionized water, stirring and dissolving;
(4) all the other components are added, stirring and dissolving;
(3) adjust ph to 5.5 ~ 7.0 obtain water preparation, and inspection, after qualified, then carry out fill and get final product.
3. the preparation of emulsion
The component of emulsion is:
A phase:
Plant sterol isostearate 0.5 part
Vitamin E acetate 1 part
Cetearyl alcohol 1 part
Sucrose Polystearic Acid Esters 2 parts
Dipalmitoyl hydroxyproline 1 part
Radix Rhodiolae extract 0.1 part
B phase: acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.1 part
Butanediol 5 parts
Glycerol 2 parts
0.5 part, stearoyl-glutamic acid sodium
EDETATE SODIUM 0.1 part
Xanthan gum 0.1 part
Deionized water surplus.
C phase: acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20 1.0 parts
D phase: aminomethyl propanol 0.2 part
1-methyl hydantoin-2-acid imide 1.0 parts
Creatine 0.2 part
Carnosine 0.2 part
Glucityl Hesperidin 0.5 part
Glycyrrhizic acid dipotassium 0.1 part
Two split the molten spore thing of culture propagation product 1.0 parts
Herba Centellae extract 0.5 part
Coenzyme Q10 wrappage 0.5 part
Prunus persica f. compressa Cactus Pedicel extract 1.0 parts
Six peptides-3 1.0 parts
Herba Saussureae Involueratae extract 0.1 part
Radix Notoginseng extract 0.1 part
Radix Angelicae Sinensis extract wrappage 0.1 part
Antiseptic 0.05 part.
The preparation method of emulsion is:
(1) by A phase all components mix homogeneously, be heated to 80 DEG C, stir and make it dissolve, obtain A phase solution;
(2) by acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer adds in deionized water, after stirring and dissolving, add other raw materials of B phase, be heated to 80 DEG C, stir and make it dissolve, obtain B phase solution;
(3) A phase solution is added in B phase solution, and add C phase all components, stir emulsifying;
(4) stirring is cooled to 45 DEG C, adds aminomethyl propanol, after stirring and dissolving, adds all the other components of D phase, stirs and is cooled to 30 ~ 35 DEG C;
(5) regulate between pH value to 5.5 ~ 6.5, obtain emulsion, inspection, after qualified, then carry out fill and get final product.
embodiment 5
1. the preparation of powder
The component of powder is:
Oligopeptide-1 1.0 part
Ginsenoside 5.0 parts
20.0 parts, mannitol.
The preparation method of powder is:
(3) all components is dissolved in appropriate deionized water, gained solution pressure cooker 121 DEG C, 0.1Mpa sterilizing 30mins.
(2) be divided in vial, put into vacuum freezing drying oven.
(3) through 45 hours vacuum freezings, drying is powdery, and capping, to obtain final product.
2. the preparation of water preparation
The component of water preparation is:
Glycyrrhiza glabra L. root extract 3.0 parts
Herba Artemisiae Scopariae flower extract 3.0 parts
Radix Mori extract 2.0 parts
Fructus Jujubae berry extract 2.0 parts
Scutellariae,radix extract 2.0 parts
Hydrolysis rice gluten 5.0 parts
Nicotiamide 3.0 parts
Hyaluronate sodium 2.0 parts
Butanediol 20.0 parts
EDETATE SODIUM 0.1 part
Glycyrrhizic acid dipotassium 2.0 parts
Pantothenylol 5.0 parts
Antiseptic 0.01 part
Deionized water is appropriate.
The molecular weight 300,000 of above-mentioned hyaluronate sodium.
The preparation method of water preparation is:
(5) hyaluronate sodium is added in deionized water, stirring and dissolving;
(6) all the other components are added, stirring and dissolving;
(3) adjust ph to 5.5 ~ 7.0 obtain water preparation, and inspection, after qualified, then carry out fill and get final product.
3. the preparation of emulsion
The component of emulsion is:
A phase:
Plant sterol isostearate 0.5 part
Vitamin E acetate 3 parts
Radix Rhodiolae extract 2.0 parts
Cetearyl alcohol 1 part
Sucrose Polystearic Acid Esters 2 parts
Dipalmitoyl hydroxyproline 1 part
B phase: acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer 0.1 part
Butanediol 5 parts
Glycerol 2 parts
0.5 part, stearoyl-glutamic acid sodium
EDETATE SODIUM 0.1 part
Xanthan gum 0.1 part
Deionized water surplus
C phase: acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20 1.0 parts
D phase: aminomethyl propanol 0.2 part
1-methyl hydantoin-2-acid imide 1.0 parts
Creatine 2.0 parts
Carnosine 2.0 parts
Glucityl Hesperidin 5.0 parts
Glycyrrhizic acid dipotassium 0.1 part
Two split the molten spore thing of culture propagation product 10.0 parts
Six peptides-3 5.0 parts
Herba Centellae extract 3.0 parts
Coenzyme Q10 wrappage 0.5 part
Prunus persica f. compressa Cactus Pedicel extract 1.0 parts
Herba Saussureae Involueratae extract 0.1 part
Radix Notoginseng extract 0.1 part
Radix Angelicae Sinensis extract wrappage 0.1 part
Antiseptic 0.05 part.
The preparation method of emulsion is:
(1) by A phase all components mix homogeneously, be heated to 80 DEG C, stir and make it dissolve, obtain A phase solution;
(2) by acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer adds in deionized water, after stirring and dissolving, add other raw materials of B phase, be heated to 80 DEG C, stir and make it dissolve, obtain B phase solution;
(3) A phase solution is added in B phase solution, and add C phase all components, stir emulsifying;
(4) stirring is cooled to 45 DEG C, adds aminomethyl propanol, after stirring and dissolving, adds all the other components of D phase, stirs and is cooled to 30 ~ 35 DEG C;
(5) regulate between pH value to 5.5 ~ 6.5, obtain emulsion, inspection, after qualified, then carry out fill and get final product.
comparative example 1
The external use skin care of comparative example 1 is made up of the component of following weight portion:
PPG-3 benzylic ether myristinate 2 ~ 5 parts
Polyglycereol-3 methyl distearate 2 ~ 5 parts
Parleam 2 ~ 5 parts
Matrixyl-3 2 ~ 5 parts
Polyglycereol-3 methyl distearate 1 ~ 3 part
Oat extract 1 ~ 3 part
Hexadeca-octadecyl alcohol 1 ~ 3 part
Glyceryl monostearate 1 ~ 3 part
Bisabolol 0.1 ~ 0.5 part
Flos Caraganae Sinicae root extract 0.1 ~ 0.3 part
Herba Centellae extract 0.1 ~ 0.5 part
Pantothenylol 0.1 ~ 0.5 part
Flos Inulae extract 0.1 ~ 0.5 part
0.1 ~ 0.5 part, hydrolyzed yeast albumen
Aesculus hippocastanum L. extract 0.1 ~ 0.5 part
Radix Glycyrrhizae acid amide 0.1 ~ 0.5 part
Boswellia serrata tree (BOSWELLIA SERRATA) extract 0.1 ~ 0.3 part
Carnosine 0.1 ~ 0.5 part
HANSHENGJIAO 0.1 ~ 0.5 part
Radix Ginseng extract 0.1 ~ 0.5 part
Ganoderma extract 0.1 ~ 0.5 part
Olibanum extract 0.1 ~ 0.5 part
Oligopeptide-1 0.1 ~ 0.5 part
Antiseptic 0.1 ~ 0.2 part
PH
observation on probation
The regulation of skin immunity adopting the embodiment of the present invention 1 to prepare, the external use skin care of delay skin aging, efficacy observation is carried out with the external use skin care of comparative example 1, in crowd, carry out efficacy test, observation user skin moisture in use, elasticity, microgroove, roughness, glossiness, corse sweat pore, colour of skin inequality, skin play the improvement situations such as bits.Choose the healthy women of about 50, the skin care item of embodiment 1 are used according to the use flow process of regulation, the 0th day, the first thoughtful 4th week carries out skin assessment to experimenter, clinical judgment comprises following skin symptom: whether wrinkle/microgroove, skin coarseness, xerosis cutis, moisture, skin elasticity, skin shine, skin splash, skin sensitivity degree, the colour of skin even.
From Fig. 1 ~ 3, compare ratio 1, after using product of the present invention, moisture content of skin continues to increase, wrinkle/microgroove, pore, the colour of skin are uneven, responsive, pigmentation, mottle, play scurf, fuel-displaced symptom and constantly improved, and skin exquisiteness, gloss, elasticity are significantly improved.
Claims (8)
1. an external use skin care for regulation of skin immunity, delay skin aging, is characterized in that, is made up of powder, water preparation and Emulsion, wherein,
Described powder comprises the component of following weight portion:
Oligopeptide-1 0.01 ~ 0. 5 part
Ginsenoside 0.1 ~ 2.0 part;
Described water preparation comprises the component of following weight portion:
Glycyrrhiza glabra L. root extract 0.10 ~ 1.50 part
Herba Artemisiae Scopariae flower extract 0.10 ~ 1.50 part
Radix Mori extract 0.10 ~ 1.00 part
Fructus Jujubae berry extract 0.10 ~ 1.00 part
Scutellariae,radix extract 0.10 ~ 1.00 part
Hydrolysis rice gluten 0.10 ~ 2.00 part
Nicotiamide 0.10 ~ 1.50 part;
Described Emulsion comprises the component of following weight portion:
Two split the molten spore thing of culture propagation product 0.5 ~ 10.0 part
Creatine 0 ~ 2.0 part
Carnosine 0 ~ 2.0 part
Glucityl Hesperidin 0 ~ 5.0 part
Six peptides-3 0 ~ 5.0 parts
Herba Centellae extract 0 ~ 3.0 part
Coenzyme Q10 wrappage 0 ~ 2.0 part
Prunus persica f. compressa Cactus Pedicel extract 0 ~ 5.0 part
Radix Rhodiolae extract 0 ~ 2.0 part
Herba Saussureae Involueratae extract 0 ~ 5.0 part
Radix Notoginseng extract 0 ~ 5.0 part
Radix Angelicae Sinensis extract wrappage 0 ~ 5.0 part
Said components is removed two and is split the molten spore beyond the region of objective existence of culture propagation product, is zero when the weight portion of all the other components is different.
2. the external use skin care of regulation of skin immunity according to claim 1, delay skin aging, is characterized in that,
The weight portion of described powder component is:
Oligopeptide-1 0.01 ~ 0.05 part
Ginsenoside 0.10 ~ 0.50 part.
3. the external use skin care of regulation of skin immunity according to claim 1, delay skin aging, is characterized in that, the weight portion of described water preparation component is:
Glycyrrhiza glabra L. root extract 0.5 ~ 1.0 part
Herba Artemisiae Scopariae flower extract 0.5 ~ 1.0 part
Radix Mori extract 0.5 ~ 1.0 part
Fructus Jujubae berry extract 0.5 ~ 1.0 part
Scutellariae,radix extract 0.5 ~ 1.0 part
Hydrolysis rice gluten 0.5 ~ 1.0 part
Nicotiamide 0.50 ~ 1.0 part.
4. the external use skin care of regulation of skin immunity according to claim 1, delay skin aging, is characterized in that, the weight portion of described Emulsion component is:
Radix Rhodiolae extract 0.1 ~ 2.0 part
Two split the molten spore thing of culture propagation product 0.5 ~ 5.0 part
Creatine 0.5 ~ 1.5 part
Carnosine 0.1 ~ 1.0 part
Glucityl Hesperidin 0.1 ~ 2.0 part
Six peptides-3 0.5 ~ 1.5 parts
Herba Centellae extract 0.1 ~ 1.0 part
Coenzyme Q10 wrappage 0.1 ~ 1.0 part
Prunus persica f. compressa Cactus Pedicel extract 0.1 ~ 3.0 part.
5. the regulation of skin immunity according to claim 1 or 4, the external use skin care of delay skin aging, is characterized in that, described Emulsion is emulsion, gel or cream.
6. regulation of skin immunity according to claim 5, the external use skin care of delay skin aging, it is characterized in that, described Emulsion also comprises the conventional substrate of cosmetics exterior-applied formulation, described conventional substrate is selected from bisabolol, N-palmityl hydroxyproline cetyl, campesterol, Jojoba seed oil, plant sterol isostearate, Vitamin E acetate, silicone oil, cetearyl alcohol, Sucrose Polystearic Acid Esters, behenyl alcohol polyethers-25, dipalmitoyl hydroxyproline, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, butanediol, glycerol, stearoyl-glutamic acid sodium, EDETATE SODIUM, xanthan gum, deionized water, acrylamide/ammonium acrylate copolymer (with) polyisobutylene (with) polysorbate-20, one or more mixing in 1-methyl hydantoin-2-acid imide and antiseptic.
7. the external use skin care of regulation of skin immunity according to claim 1 and 2, delay skin aging, it is characterized in that, described powder also comprises the conventional substrate of cosmetics exterior-applied formulation, and described conventional substrate is selected from one or more the mixing in mannitol, sodium hydrogen phosphate and sodium dihydrogen phosphate.
8. the regulation of skin immunity according to claim 1 or 3, the external use skin care of delay skin aging, it is characterized in that, described water preparation also comprises the conventional substrate of cosmetics exterior-applied formulation, and described conventional substrate is selected from one or more the mixing in hyaluronate sodium, gelatinum oxhide, butanediol, EDETATE SODIUM, glycyrrhizic acid dipotassium, pantothenylol and antiseptic.
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