CN105396120B - A kind of drug for treating acne hole and depressed scar - Google Patents

A kind of drug for treating acne hole and depressed scar Download PDF

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Publication number
CN105396120B
CN105396120B CN201510827123.7A CN201510827123A CN105396120B CN 105396120 B CN105396120 B CN 105396120B CN 201510827123 A CN201510827123 A CN 201510827123A CN 105396120 B CN105396120 B CN 105396120B
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extraction
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CN105396120A (en
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张作峰
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Ziyitang scar spot pox (Guangdong) skin Research Institute (L.P.)
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Shanghai Ziyitang Biological Science & Technology Co Ltd
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Abstract

A kind of drug for treating acne hole and depressed scar, it is made of prescription A and prescription B, prescription A is solid forms, contains mannitol, oligopeptides 1, oligopeptides 3, Magnolia cortex P.E, Rhizoma Gastrodiae extract, Horse chest Nut P.E, Radix Curcumae extract, Rhizoma Sparganii extract, Radix Berberidis extract, Radix Asteris extract, Fructus Sophorae extract, angelica extract；Prescription B is liquid form, contains water, Sensiva SC50, Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate, Herba Lycopi extract, tuckahoe extracts, Baical Skullcap root P.E, kaempferia galamga extract, phellodendron extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract, eucommia ulmoides extracts, semen vaccariae extraction, Semen Astragali Complanati extract, Chinese torreyanut extract, licorice, flores aurantii extract, Cananga odorata extract, aloe extract.

Description

A kind of drug for treating acne hole and depressed scar
Technical field
The present invention relates to a kind of drug, especially a kind of drug for treating acne hole and depressed scar.
Background technology
Acne is a kind of chronic inflammatory skin on pilosebaceous follicle, due to being mainly in teenager, is also referred to as whelk. The factors such as the generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction are close It is related.Acne, in the event of skin injury, can form acne hole and other depressed scars during rehabilitation, can be to people Psychology and social activity produce serious influence.Treatment acne hole and depressed scar most efficient method are laser mill skin operations at present, But this method price is very high, it is also very big to the injury of skin.The drug of depressed scar can be repaired on the market Usually also containing certain hormone, and the drug therapy cycle is longer, and side effect is larger.
The content of the invention
It is pure natural in order to solve the above technical problem, the present invention provides a kind of drug for treating acne hole and depressed scar It is environmentally protective, without hormone, defective tissue cytothesis can be promoted, be conducive to the growth of cell at skin depressions.The medicine Object is made of prescription A and prescription B,
Prescription A is solid forms, and the parts by weight of material composition and each substance in the prescription are：
11-19 parts of mannitol, -1 4-12 parts of oligopeptides, -3 4-12 parts of oligopeptides, 8-16 parts of Magnolia cortex P.E, Rhizoma Gastrodiae extraction 6-14 parts of object, 24-32 parts of Horse chest Nut P.E, 12-20 parts of Radix Curcumae extract, 4-12 parts of Rhizoma Sparganii extract, Radix Berberidis extract 32-40 parts, 12-20 parts of Radix Asteris extract, 6-14 parts of Fructus Sophorae extract, 4-12 parts of angelica extract；
Prescription B is liquid form, and the parts by weight of material composition and each substance in the prescription are：
100 parts of water, 35-65 parts of Sensiva SC50,14-26 parts of Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate 28-44 parts, 14-22 parts of Herba Lycopi extract, 4-12 parts of tuckahoe extracts, 4-12 parts of Baical Skullcap root P.E, kaempferia galamga extract 20-28 Part, 8-16 parts of phellodendron extract, 4-12 parts of Radix Morindae Officinalis extract, 4-12 parts of Radix Gentianae Macrophyllae extract, 32-40 parts of eucommia ulmoides extracts, king 14-22 parts of row extract, 28-36 parts of Semen Astragali Complanati extract, 8-16 parts of Chinese torreyanut extract, 18-26 parts of licorice, orange are not stayed 2-10 parts of flower extract, 2-10 parts of Cananga odorata extract, 2-10 parts of aloe extract.
As the present invention a kind of preferred technical solution,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
13-17 parts of mannitol, -1 6-10 parts of oligopeptides, -3 6-10 parts of oligopeptides, 10-14 parts of Magnolia cortex P.E, Rhizoma Gastrodiae carry Take 8-12 parts of object, 26-30 parts of Horse chest Nut P.E, 14-18 parts of Radix Curcumae extract, 6-10 parts of Rhizoma Sparganii extract, barberry extraction 34-38 parts of object, 14-18 parts of Radix Asteris extract, 8-12 parts of Fructus Sophorae extract, 6-10 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 40-60 parts of Sensiva SC50,16-24 parts of Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate 32-40 parts, 16-20 parts of Herba Lycopi extract, 6-10 parts of tuckahoe extracts, 6-10 parts of Baical Skullcap root P.E, kaempferia galamga extract 22-26 Part, 10-14 parts of phellodendron extract, 6-10 parts of Radix Morindae Officinalis extract, 6-10 parts of Radix Gentianae Macrophyllae extract, 34-38 parts of eucommia ulmoides extracts, king Do not stay 16-20 parts of row extract, 30-34 parts of Semen Astragali Complanati extract, 10-14 parts of Chinese torreyanut extract, 20-24 parts of licorice, 4-8 parts of flores aurantii extract, 4-8 parts of Cananga odorata extract, 4-8 parts of aloe extract.
As the present invention a kind of preferred technical solution,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
15 parts of mannitol, 8 parts of oligopeptides -1,8 parts of oligopeptides -3,12 parts of Magnolia cortex P.E, 10 parts of Rhizoma Gastrodiae extract, sieve Suo 28 parts of seed extract, 16 parts of Radix Curcumae extract, 8 parts of Rhizoma Sparganii extract, 36 parts of Radix Berberidis extract, 16 parts of Radix Asteris extract, Chinese scholartree 10 parts of horn extraction, 6 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 50 parts of Sensiva SC50,20 parts of Sodium Hyaluronate, 36 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 18 parts of extract, 8 parts of tuckahoe extracts, 8 parts of Baical Skullcap root P.E, 24 parts of kaempferia galamga extract, 12 parts of phellodendron extract, Morinda officinalis 8 parts of extract, 8 parts of Radix Gentianae Macrophyllae extract, 36 parts of eucommia ulmoides extracts, 18 parts of semen vaccariae extraction, 32 parts of Semen Astragali Complanati extract, Chinese torreya 12 parts of seed extract, 22 parts of licorice, 6 parts of flores aurantii extract, 6 parts of Cananga odorata extract, 6 parts of aloe extract.
The Magnolia cortex P.E, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, the extraction side of Radix Berberidis extract Method is：Clean, chopping, with acetic acid refluxing extraction 3-5 time, merging extracting solution, be dried in vacuo to get.
The Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, the extracting method of angelica extract are：It cleans, cuts It is heated to 45-65 DEG C after broken and refined honey mixing, keeps the temperature 3-5 h, using water as solvent after cooling, with ultrasonic wave extraction 3-6 h, After filtering be dried in vacuo to get.
The phellodendron extract, Radix Morindae Officinalis extract, the extracting method of Radix Gentianae Macrophyllae extract are：It cleans, chopping is returned with ethyl alcohol Stream extraction 3-5 times, merges extracting solution, is concentrated to give liquid extract.
The Herba Lycopi extract, tuckahoe extracts, Baical Skullcap root P.E, the extracting method of Rhizoma Kaempferiae extract are：It cleans, cuts It is broken, using water as solvent, with ultrasonic wave extraction 3-6 h, liquid extract is concentrated to give after filtering.
The eucommia ulmoides extracts, semen vaccariae extraction, Semen Astragali Complanati extract, the extracting method of Chinese torreyanut extract are：It washes Only, wheat bran fries 0.5-1 h, and temperature is 120-130 DEG C, filters wheat bran after cooling, using ethyl alcohol as solvent, uses ultrasonic wave extraction 3-6 h are concentrated to give liquid extract after filtering.
The licorice, flores aurantii extract, Cananga odorata extract, aloe extract are obtained by supercritical carbon dioxide extracting It arrives, extraction temperature is 30-35 DEG C, and extracting pressure is 18-25 MPa, and resolution temperature is 42-53 DEG C, and parsing pressure is 5-7 MPa。
The application method of the drug of a kind of above-mentioned treatment acne hole and depressed scar, by the solid and liquid object with weight Measure ratio 1：（50-75）Required position is directly applied to after mixing.
With reference to the above, the advantages and features described further below for being more conducive to understand the present invention.
Specific embodiment
Unless otherwise defined, all technologies used herein and scientific terminology have and the common skill of fields of the present invention The normally understood identical meaning of art personnel.When there is a conflict, the definition in this specification shall prevail.
Equivalent, concentration or other values or parameter are excellent with scope, preferred scope or a series of upper limit preferred values and lower limit During the Range Representation that choosing value limits, this, which is appreciated that, specifically discloses by any range limit or preferred value and any scope All scopes that any pairing of lower limit or preferred value is formed, regardless of whether the scope separately discloses.For example, when open During scope " 1 to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise the scope intention include its end value with All integers and fraction in the range.
Term " refined honey " refers to：Honey is put in pot, is heated to after seething with excitement slowly, uses slow boiling instead, slightly boiling is kept, and removes Then foam and floating wax filter off dead bee, impurity with sieve sieve or gauze, then are poured into pot, be heated to 116 DEG C -118 DEG C, Panful plays flake bubble, with the toughness of hand sth.s made by twisting, two refer between there is no when growing white silk and occurring, take the dish out of the pot rapidly.
A kind of drug for treating acne hole and depressed scar, is made of prescription A and prescription B,
Prescription A is solid forms, and the parts by weight of material composition and each substance in the prescription are：
11-19 parts of mannitol, -1 4-12 parts of oligopeptides, -3 4-12 parts of oligopeptides, 8-16 parts of Magnolia cortex P.E, Rhizoma Gastrodiae extraction 6-14 parts of object, 24-32 parts of Horse chest Nut P.E, 12-20 parts of Radix Curcumae extract, 4-12 parts of Rhizoma Sparganii extract, Radix Berberidis extract 32-40 parts, 12-20 parts of Radix Asteris extract, 6-14 parts of Fructus Sophorae extract, 4-12 parts of angelica extract；
Prescription B is liquid form, and the parts by weight of material composition and each substance in the prescription are：
100 parts of water, 35-65 parts of Sensiva SC50,14-26 parts of Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate 28-44 parts, 14-22 parts of Herba Lycopi extract, 4-12 parts of tuckahoe extracts, 4-12 parts of Baical Skullcap root P.E, kaempferia galamga extract 20-28 Part, 8-16 parts of phellodendron extract, 4-12 parts of Radix Morindae Officinalis extract, 4-12 parts of Radix Gentianae Macrophyllae extract, 32-40 parts of eucommia ulmoides extracts, king 14-22 parts of row extract, 28-36 parts of Semen Astragali Complanati extract, 8-16 parts of Chinese torreyanut extract, 18-26 parts of licorice, orange are not stayed 2-10 parts of flower extract, 2-10 parts of Cananga odorata extract, 2-10 parts of aloe extract.
As the present invention a kind of preferred technical solution,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
13-17 parts of mannitol, -1 6-10 parts of oligopeptides, -3 6-10 parts of oligopeptides, 10-14 parts of Magnolia cortex P.E, Rhizoma Gastrodiae carry Take 8-12 parts of object, 26-30 parts of Horse chest Nut P.E, 14-18 parts of Radix Curcumae extract, 6-10 parts of Rhizoma Sparganii extract, barberry extraction 34-38 parts of object, 14-18 parts of Radix Asteris extract, 8-12 parts of Fructus Sophorae extract, 6-10 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 40-60 parts of Sensiva SC50,16-24 parts of Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate 32-40 parts, 16-20 parts of Herba Lycopi extract, 6-10 parts of tuckahoe extracts, 6-10 parts of Baical Skullcap root P.E, kaempferia galamga extract 22-26 Part, 10-14 parts of phellodendron extract, 6-10 parts of Radix Morindae Officinalis extract, 6-10 parts of Radix Gentianae Macrophyllae extract, 34-38 parts of eucommia ulmoides extracts, king Do not stay 16-20 parts of row extract, 30-34 parts of Semen Astragali Complanati extract, 10-14 parts of Chinese torreyanut extract, 20-24 parts of licorice, 4-8 parts of flores aurantii extract, 4-8 parts of Cananga odorata extract, 4-8 parts of aloe extract.
As the present invention a kind of preferred technical solution,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
15 parts of mannitol, 8 parts of oligopeptides -1,8 parts of oligopeptides -3,12 parts of Magnolia cortex P.E, 10 parts of Rhizoma Gastrodiae extract, sieve Suo 28 parts of seed extract, 16 parts of Radix Curcumae extract, 8 parts of Rhizoma Sparganii extract, 36 parts of Radix Berberidis extract, 16 parts of Radix Asteris extract, Chinese scholartree 10 parts of horn extraction, 6 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 50 parts of Sensiva SC50,20 parts of Sodium Hyaluronate, 36 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 18 parts of extract, 8 parts of tuckahoe extracts, 8 parts of Baical Skullcap root P.E, 24 parts of kaempferia galamga extract, 12 parts of phellodendron extract, Morinda officinalis 8 parts of extract, 8 parts of Radix Gentianae Macrophyllae extract, 36 parts of eucommia ulmoides extracts, 18 parts of semen vaccariae extraction, 32 parts of Semen Astragali Complanati extract, Chinese torreya 12 parts of seed extract, 22 parts of licorice, 6 parts of flores aurantii extract, 6 parts of Cananga odorata extract, 6 parts of aloe extract.
Cortex Magnoliae Officinalis is Magnoliaceae, magnolia, is used as medicine with dry hide, root skin and branch skin, bitter, pungent, warm-natured, returns spleen, stomach, Lung, large intestine channel.Cortex Magnoliae Officinalis contains Neolignans, such as：Magnolol, honokiol, the new phenol of magnolia obovata, 6 '-O- methyl and thickness Plain phenol, Cortex Magnoliae Officinalis aldehyde B, C, Cortex Magnoliae Officinalis lignan A, B, C, D, E and Taiwan sassafrases aldehyde；Also containing monoterpene Neolignans, such as： Peppery menthyl magnolol, double peppery menthyl magnolols, peppery menthyl honokiol and imperial born of the same parents' base magnolol；Also containing drop lignan Class compound, such as：Taiwan sassafrases phenol, Cortex Magnoliae Officinalis triphenol B, magnaldehyde D, E；Also containing double Neolignans, such as：Cortex Magnoliae Officinalis Lignan F, G, H and I；Also contain alkaloid, such as：Magnocurarine and salicifoline；Also contain volatile oil, such as：β- Eucalyptol, cubebol, guaiol, cymol, Isosorbide-5-Nitrae-Cineole, cloves alkene, linalool, α-terpinene, α-humulus grass Alkene, 4- terpinenols, globulol and α-limonene；Also contain and also contain sinapyladehyde, syringaresinol,-the O- of syringaresinol -4 ' β - D- glucopyanosides and 1- (4- hydroxy 3-methoxybenzenes base) -2- [4- (ω-hydroxypropyl) -2- methoxyphenoxies] -1,3- Propylene glycol.With eliminating dampness dissolving phlegm, the effect of lower gas removes full.
Rhizoma Gastrodiae is orchid family Gastrodia herbaceos perennial, is used as medicine with rhizome, sweet in flavor, mild-natured, return liver warp.Content in Rhizoma Gastrodiae Higher main component is gastrodin, also referred to as Gastrodin, and chemical composition is p- methylol benzene-β-D- glucopyanosides；Separately The glucoside of ether containing Rhizoma Gastrodiae, chemical composition are double-(4- acrinyls)-ether-mono--β-D- glucopyanosides.Contain p- hydroxyphenylmethyl again Alcohol, p-hydroxy benzaldehyde, 4- acrinyl methyl ethers, 4- (4'- hydroxyls benzyloxy) methyl benzyl ether, double (4- acrinyls) ethers, three [4- (β-D- glucopyras glycosyloxy) benzyl] citric acid ester.There is Inflammation Zhijing, Pinggan Yang, dispelling wind and removing obstruction in the meridians.
Buckeye be Hippocastanaceae plant horse chestnut dry mature seed, sweet in flavor, warm-natured, Return liver, stomach.Buckeye contains Fat oil, starch, fiber, crude protein.Fat oil is mainly oleic acid and stearic glyceride.Stop with regulating the flow of QI to ease the stomach and stomach The effect of pain.
Radix Curcumae is the root tuber of zingiberaceous plant RADIX CURCUMAE, not the root tuber of zingiberaceous plant turmeric or zingiberaceous plant curcuma zedoary, acrid flavour, Hardship, it is cool in nature.Radix Curcumae main component is volatile oil, amphene, camphor, sesquiterpene, curcumene, sesquiterpene alcohols.Also containing curcumin, Demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone.Another starch-containing, fat oil, weld, Eucarvone and phellandrene.Clear away heart-fire with cool blood, the effect of stasis-dispelling and pain-killing, promoting qi circulation and removing obstruction in the collateral, normalizing gallbladder to cure jaundice.
Trigone is the stem tuber of Sparganiaceae plant rhizoma scirpi, and acrid flavour, hardship are mild-natured.The main chemical compositions of trigone are benzene second Alcohol, hydroquinone, hexadecylic acid also have dehydro-α-curcumene, 3,4- dihydro -8- hydroxy-3-methyl -1H-2- chromenes -4- Ketone, 1- hydroxyl -2- acetyl group -4- methylbenzenes, beta-elemene, 2- furan alcohols, 2- acetyl pyrroles etc..Also contain a variety of organic acids, Such as：Succinic acid, trigone acid, 9,11- octadecadienoic acids, 9,12 octadecadienoic acid, 10- nonadecenoic acids, 11- icosa alkenes Acid, benzoic acid, 3- benzene -2- acrylic acid, decanedioic acid and the aliphatic acid containing C8-C10, C12, C14-C20.Also contain ononis spinosa Element, stigmasterol, cupreol, Daucosterol.With blood-breaking, the effect of Xiao Ji Zhi Tong.
Barberry pierces the root skin of black pearl, berberis brachypoda Maxim, black stone pearl etc. or stem skin for Berberidaceae plant.Bitter, it is cold in nature, return Liver, stomach, large intestine channel.Barberry Alkaloid containing quaternary ammonium：Jamaicin, jateorrhizine, palmatine, jateorrhizine, magnolia Alkali；Tertiary amine Alkaloid：Berbamine etc..With heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating.
Aster is feverfew aster, is used as medicine with root and rhizome, acrid flavour, hardship are warm-natured, distributed in lung channel.Main alcohol containing freidelin, Freidelin, shionon, astersaponin, Quercetin, containing lachnophyllol, acetic acid hair leaf ester, anisole, hydrocarbon, aliphatic acid, virtue in volatile oil Fragrant race's acid.With moistening lung to lower qi, the effect of stopping coughing and removing phlegm.
The Fructus Sophorae is legume Chinese scholartree, and with fruit medicine, bitter is cold in nature, Return liver, large intestine channel.Mainly contain flavonoid Object, genistein, genistein -7- β-D- cellobioses glucoside, genistein -7- glucosulfone bases rhamnoside, Kaempferol, Kaempferol -3-O- rhamnopyranosyls diglucoside, Kaempferol -3,7-O- diglucosides, Quercetin, rutin, sophoricoside, Chinese scholartree Belong to double glucoside, sophoraflavonolosides.Also containing triterpene compound and lysine, asparagus fern acid amide, arginine, serine, glutamic acid, Soviet Union's ammonia The free amino acids such as acid, alanine, proline, tryptophan, valine, phenylalanine, leucine, isoleucine.Also containing life Alkaloids, such as：Sparteine, N-Methylcytisine, sophocarpine, matrine, stizolamine.Also containing galactomannan, phosphorus Fat and phytin, phytohemagglutin phytolectin etc..Also containing oleic acid, linoleic acid, leukotrienes, palmitic acid, stearic acid, octadecenoic acid, Octadecadienoic acid, octatecatrienoic acid.With clearing heat-fire, the effect of cooling blood and hemostasis.
When being classified as umbelliferae angelica, it is used as medicine with root, sweet in flavor, pungent, warm-natured, Return liver, the heart, the spleen channel.Radix Angelicae Sinensis mainly contains Butylidenephthalide, the positive the eleventh of the twelve Earthly Branches ketone of adjacent carboxyl benzene, δ -2,4- dihydros acid phthalic anhydride, sucrose, vitamin B12, vitamin A, oleic acid, linoleic acid, Sitosterol, Ligustilide, forulic acid, succinic acid, Scopoletin, umbelliferone, vanillic acid, choline, sickleleaf celery alcohol, sickleleaf celery Ketone, falcarindiol, uracil, adenine, a variety of amino acid and lot of trace metallic element, such as calcium, copper, zinc, iron, potassium. With replenishing and activating blood, menstruction regulating and pain relieving, the effect of relaxing bowel.
Herba Lycopi is labiate hair leaf lycopus lucidus, is used as medicine with cauline leaf, bitter, pungent, warm-natured, Return liver, the spleen channel.Mainly contain There are volatile oil, glycoside, tannin and resin, also containing glycosides displayed, phenols, amino acid, organic acid, saponin, glucose, gala Sugar, Herba Lycopi sugar, sucrose, gossypose, stachyose, fructose.Spleen and qi and blood are rushed down with tonifying liver, the effect of sharp tendon and vessel.
Poria cocos is On Polyporaceae Poria cocos, is used as medicine with sclerotium, mild-natured, sweet in flavor, the thoughts of returning home, lung, the spleen channel.Poria cocos main component For triterpene compound, pachymic acid, 16 Alpha-hydroxy eburicoic acids, 3 beta-hydroxies -7,9 (11), 24- wool steroid triolefins -21- acid, Poria cocos Sour methyl esters, 16 Alpha-hydroxy eburicoic acid methyl esters, 7,9 (11)-dehydroabietate methyl esters, 3 β, 16 alpha-dihydroxys -7,9 (11), 24 (31)-wool steroid triolefin -21- acid methyl esters, total triterpenes methyl esters, the loose Siberian cocklebur acid of 3- hydrogenations, eburicoic acid, dehydroeburicoic acid, Poria cocos are new Acid, β-aromadendrol acetic acid, 7,9 (11) dehydroabietate.Polysaccharide, pachyman, Poria cocos time poly-, callose H11.It is other, Ergosterol, octanoic acid, caprylate, hendecanoic acid, lauric acid, lauric acid ester, palmitic acid, dodecylene acid esters and inorganic member Element.With eliminating dampness and diuresis, the effect of strengthening the spleen and stomach, antitoxic heart-soothing and sedative.
Radix scutellariae is labiate radix scutellariae, is used as medicine with root, bitter is cold in nature, return lung, courage, spleen, large intestine, small intestinl channel.Containing flavones Class compound：Baicalein, neobaicalein, baicalin, wogonin, wogonoside, oroxylin A, 7- methoxyl group baicalein, Huang A kind of reed mentioned in ancient books flavones, dihydro oroxylin A, Chrysin, 2,5,8- trihydroxy -7- methoxy flavones, 2,5,8- trihydroxy -6,7- dimethoxies Base flavones, 4,5,7- trihydroxy -6- methoxy flavanones, 2,3,5,6,7- penta hydroxy groups flavanones, wogonin -5- β-D- grapes Glucoside, 2- (3- hydroxyl -4- methoxyphenyls)-ethyl -1-O- α-L- rhamnopyranosyls (1 → 3)-β-D (4- asafoetides acyl group)-grape Sugar, Chrysin -6-C- α-L-arabinose glucoside, Chrysin -6-C- α-L-arabinose glucoside -8-C- β-D-Glucose glucoside, (2S) - 2,5,6,7- tetrahydroxys flavanones, 5,7,2,6- kaempferols, 5,8- dihydroxy -6,7- dimethoxy flavones, 5,7,4- tri- Hydroxyl -8- methoxy flavones, oroxylin A-7-O- glucuronides, 5,7,2- trihydroxies methoxy flavone, 5,2- dihydroxies Base -6,7,8- trimethoxy flavones, Norwogonin, dihydro baicalein, 5,7,2- trihydroxyflavones, 5,7,2- trihydroxies - 8,6- dimethoxy flavones, 5,7,2,5- tetrahydroxy -8,6- dimethoxy flavones, 5,2,5- trihydroxies trimethoxy flavone, Huang A kind of reed mentioned in ancient books element -7-O- β-D- glucopyanosides, 5,7,2- trihydroxy -8- methoxy flavones, 5,2,6- trihydroxy -7,8- dimethoxys Flavones, 5,2,6- trihydroxies -6-methoxy-2-phenyl-4H-chromen-4-one, 5,7,2,3- kaempferols, 3,5,7,2,5,6- pentahydroxyflavones, (2S) -7,2,6- trihydroxy -5- methoxy flavanones, 2,6,2,4- tetrahydroxy -6- methoxyl groups chalcone, 5,7,2,5- tetrahydroxys Flavones, left-handed eriodictyol, Sculellaria barbata kind element, 2-O- β-D- glucopyanosides.Also contain cupreol, campesterol and beans steroid Alcohol.With heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating, hemostasis, tocolysis.
Kaempferia galamga is more Zingiber Kaempferia kaempferia galamgas, is used as medicine with rhizome, acrid flavour is warm-natured, returns spleen, stomach.Chemical composition has kaempferia galamga Element, the ingredient of kaempferia galamga volatile oil have that cinnamic acid second vinegar, p-methoxycinnamic acid, p-methoxycinnamic acid second is cruel, cinnamic acid isopropyl Vinegar, cyclohexyl-acetic acid second are cruel, 3,7- dimethoxycoumarins, hendecanone, 2- heptadecanones, 9- hydroxyls-methyl n-heptyl ketone, 10- ten One alkynes -1- alcohol, benzene alkene, borneol etc..With warming middle-JIAO for eliminating dampness, the effect of promoting qi circulation and relieving pain.
Cortex Phellodendri is rutaceae wampee, is used as medicine with bark, bitter is cold in nature, returns kidney, bladder warp.Containing jamaicin, Cortex Phellodendri Alkali, magnoflorine, jateorrhizine, palm leaf coculine, candicine, menispermum dauricum appoint alkali, guanidine；Separately containing limonin, obakunone, γ- Sitosterol, cupreol, campesterol, stigmasterol, 7-Dehydrostigmaslerol, Dictamnolide, obacunonic acid, blue or green fluorescent acid, 24- are sub- Methyl ring jackfruit alcohol, γ-hydroxyl butylene lactone derivatives, milk tree alcohol-B, berberrubine.With heat-clearing and damp-drying drug, purging intense heat removes The effect of steaming, detoxification sore treatment.
Morinda officinalis is madder wort Morinda officinalis, is used as medicine with root, sweet in flavor, pungent, warm-natured, returns kidney, Liver Channel.It is mainly different containing methyl Rubican, Rubiadin 1-methylether, Physcion, 2- hydroxyl methylols anthraquinone, 1- hydroxy-anthraquiones, 1- hydroxyl -2- first Base anthraquinone, 1,6- dihydroxy -2,4- dimethoxys anthraquinone, 1,6- dihydroxy -2- methoxy anthraquinones, 2-methylanthraquinone, pinesap Glucoside, four acetyl asperulosides.Also containing glucose, mannose, cupreol, palmitic acid, vitamin C, nonadecane, 24- ethyls Cholesterine.It with tonifying the kidney and support yang, strengthens muscles and bones, the effect of dispelling wind and eliminating dampness.
Bark of ash is gentianaceae plant bark of ash, is used as medicine with root, acrid flavour, hardship are mild-natured, return stomach, liver, gallbladder channel.Mainly contain bark of ash Alkali first, gentianidine, gentianal, swertiamarin, montanic acid, montanic acid methyl esters, 3,4-Secoursa-4(23),12-dien-3-oic acid, α-amyrin, cupreol, Cupreol-β-D-Glucose glucoside.With there is the effect of wind-damp dispelling, clearing away damp-heat, stopping numbness pain, reducing the asthenic fever.
Cortex Eucommiae is Eucommiaceae plant Cortex Eucommiae, is used as medicine with bark, sweet in flavor, warm-natured, returns liver and kidney channel.Mainly contain dextrorotation cloves Syringaresinol, dextrorotation botany bar gum phenol glycoside, cloves glycerine-β-syringaresinol ether 4 ', 4 ' ' '-bis- glycosides, the right side Revolve pinoresinol, dextrorotation table pinoresinol, dextrorotation pinoresinol glycoside, dextrorotation pinoresinol double glycoside, dextrorotation 1- hydroxyl rosin Phenol, dextrorotation 1- hydroxyls pinoresinol -4 '-glycoside, dextrorotation 1- hydroxyls pinoresinol -4 ' '-glycoside, dextrorotation 1- hydroxyl rosin Phenol -4 ', 4 ' '-bis- glycosides, Dihydrodehydodiconiferyl alcohol, Soviet Union's formula dihydroxy dehydrodiconiferylalcohol, erythro form dihydroxy dehydrogenation two Coniferyl alcohol, dehydrodiconiferylalcohol -4, r '-diglucoside, left-handed olivil, left-handed olivil -4 '-glucose Glucoside, left-handed olivil -4 ' '-glycoside, left-handed olivil -4 ', 4 ' '-bis- glycosides, dextrorotation ring Chinese olive tree The double glycosides of fat element, dextrorotation Cortex Eucommiae Syringaresinol, Cortex Eucommiae element A, dextrorotation Cortex Eucommiae Syringaresinol, Auricled Hedyotis Herb lipidol C-4 ' ', 4 ' '-bis- grapes Glucoside, Liriodendron glucoside, mandarin orange category glucoside B, Aucubin, all eucommito, square rafter element, all square rafter glucoside, all square rafter glucoside, carpet bugle Glucoside, harpagide acetic acid esters, bugle glucoside, ulmoprenol, ulmoprenol glucoside I, caffeic acid, chlorogenic acid, methyl chlorogenate, vanilla Acid, betulin, betulic acid, ursolic acid, cupreol, Daucosterol, phenylalanine, lysine, tryptophan, methionine, Soviet Union Propylhomoserin, valine, leucine, isoleucine, glutamic acid, cystine, histidine, Cortex Eucommiae enol, Kaempferol, tartaric acid, gala Sugar alcohol, N-triacontanol, positive nonacosane, gutta-percha.With filling liver kidney, the effect of strengthening the bones and muscles, tocolysis.
The seed of cowherb is pinkwort cow-fat, is used as medicine with seed, bitter is mild-natured, Return liver, stomach.Mainly contain king Row saponin A, B, C, D, seed of cowherb glycosides displayed, isosaponaretin, phytin, phosphatide, stigmasterol, seed of cowherb xanthene are not stayed Ketone, cow-fat xanthone, 1,8- dihydroxy -3,5- dimethoxy 9- xanthones.With invigorate blood circulation, lower newborn the effect of subsiding a swelling.
Semen astragali complanati is the flat stem astragalus of legume, is used as medicine with seed, sweet in flavor, warm-natured, returns liver and kidney channel.Mainly contain sucrose, Glucuronic acid, mucilaginous substance, amino acid, bitter principle, choline, glycine betaine, folic acid, 2 ', 4 '-dihydroxy -5,6- dimethoxys are different Flavane, kumatakenin, linoleic acid, leukotrienes, cupreol.With liver-kidney tonifying, the effect of improving eyesight controlling nocturnal emission with astringent drugs.
Chinese torreyanut is taxaceae plant Chinese torreya, is used as medicine with seed, sweet in flavor, mild-natured, return lung, stomach, large intestine channel.Mainly contain palm Acid, stearic acid, oleic acid, linoleic glyceride, sterol, oxalic acid, glucose, polysaccharide, volatile oil, tannin.With killing insect and eliminating accumulation, It moistens the lung and relieve the cough, the effect of moistening dryness for relaxing bowels.
Radix Glycyrrhizae is glycyrrhizic legume, is used as medicine with rhizome, sweet in flavor, mild-natured, the thoughts of returning home, lung, spleen, stomach.Licorice and rhizome It is main to contain triterpenoid saponin.Wherein main one kind, is commonly called as glycyrrhizin, is the sweet ingredient of Radix Glycyrrhizae, is 18 β-Radix Glycyrrhizae of 1 molecule The glucuronic acid of hypo acid and 2 molecules combines the sylvite and calcium salt of the glycyrrhizic acid of generation.Other triterpenoid saponins have：Glycyrrhiza Uralensis Saponin A, B and glycyrrhizic acid A3、B2、C2、D3、E2、F3、G2、H2、J2、K2.Chlorins compound containing flavones again：Liquiritigenin, Radix Glycyrrhizae Glucoside, Isoliquiritigenin, isoliquiritin, neoliquriitin, close isoliquiritin, licoricidin, Licoricone, formoononetin, 5-O- Methyl Radix Glycyrrhizae sheet is fixed, liquiritigenin -4 '-celery sugar glycoside, liquiritigenin -7,4 '-diglucoside, vicenin-2 It is bis--glucosyl groups of 6,8- apiolin, ononin, isolicoflavonol, Isoliquiritigenin -4 '-celery sugar grape glucoside.Also contain Coumarins compound：Radix Glycyrrhizae coumarin, glycyol, isoglycyol, Radix Glycyrrhizae coumarin -7- methyl ethers, neoglycyrol, Radix Glycyrrhizae pyrans Coumarin, licocoumarone etc..Contain alkaloid again：5,6,7,8- tetrahydrochysene -4- methylquinolines, 5,6,7,8- tetrahydrochysene -2,4- diformazans Base quinoline, 3- methyl -6,7,8- three hydrogen pyrrolo- [1,2-a] pyrimidine -3- ketone.Also contain licobenzofuran also known as Radix Glycyrrhizae new wood Fat element, cupreol, n-tricosane, n-hexacosane, heptacosane etc..With invigorating the spleen and benefiting qi, clearing heat and detoxicating, eliminating the phlegm stops The effect of cough, relieving spasm to stop pain.
Flores aurantii is the flower of Rutaceae bigarabe, mainly contains limonene, linalool, geraniol, nerol, aldehyde, adjacent aminobenzene Methyl formate, aurantiamarin, rutin, aurantiin.
Yilan is Annonaceae Yilan platymiscium, is used as medicine with flower, mainly contains linalool, geraniol, nerol, pine tar Alcohol, benzyl alcohol, benzyl carbinol, leaf-alcohol, eugenol, paracresol, paracresol ether, safrole, isosafrole, methyl heptenone, Valeric acid, benzoic acid, salicylic acid, geranyl acetate, gaultherolin, firpene, farnesene, carypohyllene.
Aloe is liliaceous plant aloe barbadensis Miller, is used as medicine with leaf, bitter is cold in nature, Return liver, stomach, large intestine channel.Aloe is main Containing aloin, different aloin, 7- hydroxyls aloin, 5- hydroxyl aloins A, resin, Altheine, aspartic acid, DL- threonines, L-Trp, cholesterine, campesterol, cupreol, lupeol, apple Acid, citric acid, tartaric acid, D-Glucose, D-MANNOSE, pectic acid, D- galactans, arabinose and rhamnose.With rushing down The effect of fire removing toxic substances, stagnation resolvation desinsection.
Mannitol, also known as PEARLITOL 25C, hexitol, for white orthorhombic system acicular crystal, sugariness is about granulated sugar 57%-72%.Mannitol can be catalyzed by nickel and is prepared, such as：By 50% sucrose solution in 5-15 MPa air pressures and 120- It is reduced at a temperature of 150 DEG C under Raney nickel effect.
Mannitol can also be extracted from natural plants.Such as：It will be fresh（Or it dries or passes through and impregnate）Kelp or The mucus on seaweed surface is washed down, and with alkali precipitation, filtering, filtrate is acidified, filtering, and crude product is made in filtrate after concentration.It will Crude product is washed with ethyl alcohol, recrystallize in water to get.
Mannitol can also be obtained by electrolytic method.Such as：Using sucrose or glucose as raw material, electricity is made into sodium sulphate Solve liquid, to amalgamate stereotype as cathode, using stereotype as anode, using porous ceramics as membrane, be electrolysed, can be made mannitol and Then the mixed liquor of D-sorbite both makes to separate, refine to get.
Oligopeptides is the linear peptides formed by 2-6 amino acid by peptide key connection, and molecular weight section is generally in 1000 dalton Hereinafter, it is not required to digest in human body, you can directly absorb.Oligopeptides be selected from oligopeptides -1, oligopeptides -2, oligopeptides -3, oligopeptides -4, oligopeptides -5, At least one of oligopeptides -6.As a kind of preferred technical solution of the present invention, the oligopeptides is selected from oligopeptides -1 and oligopeptides -3 Composition.
Sensiva SC50 is a kind of moderate emollient of spreading property, moisturizer and wetting agent.It can be formulated improving While moisturizing effect there is soft and smooth skin sense again, while the growth and breeding for causing the bacterium of peculiar smell can be inhibited, there is deodorization effect Fruit.In addition, Sensiva SC50 influences from hydrolysis, temperature and pH value, it is compatible with other dispensings.
Hyaluronic acid is by (1 → 3) -2- acetylaminohydroxyphenylarsonic acid 2- deoxidations-β-D-Glucoses-(1 → 4)-O- β-D-Glucose aldehyde A kind of high polymer that the disaccharide recurring unit of acid is formed, is acid mucopolysaccharides.Sodium Hyaluronate forms one in water The thick viscoelastic solution of kind, has physiology acid-base value and ionic strength.It can be extracted and obtained by cockscomb and umbilical cord.Such as：It will be new Freshly-slaughtered poultry chops up after being preced with 10 kg washings, adds the sodium hydroxide solution of doubling dose, 30 min of extraction is stirred at 60 DEG C, then It is neutralized with trichloroacetic acid solution, addition catalase decomposes remaining hydrogen peroxide.Then deproteinized is removed with trichloroacetic acid, Make the trichloroacetic acid concentration of extracting solution become 5 %.After filtering, neutralized with the sodium hydroxide solution of 10 weight %, by it in flowing water It dialyses after 24 h, filters.The filtrate of about 15 L is obtained, after its heat sterilization, about adds the absolute ethyl alcohol of 45 L, is stirred, It is obtained after the sediment of precipitation is filtered.
Saccharomycetes to make fermentation lysate filtrate is that broken wall obtains that lysate is filtered to be obtained after being fermented by yeast.Wherein ammonia 30 more than % of base acid content, 50 more than % of total protein, 10 more than % of nucleotide have moisturizing, activation and other effects.Amino acid is skin The main component of natural moisturizing factor, is easily absorbed by the skin in skin cuticula, the epidermis of aging is made to recover elasticity, delaying skin declines Always.Nucleic acid and nucleotide are the central genetic substances of human body, have and boost metabolism, improve the works such as protein aggregate velocity With enhancing immunity function, enhancing superoxide dismutase activity improve skin antiradical activities.In addition, wherein a small amount of dimension The nutrients such as raw element and minerals can also provide sufficient nutrition for skin.
The Magnolia cortex P.E, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, the extraction side of Radix Berberidis extract Method is：Clean, chopping, with acetic acid refluxing extraction 3-5 time, merging extracting solution, be dried in vacuo to get.
The Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, the extracting method of angelica extract are：It cleans, cuts It is heated to 45-65 DEG C after broken and refined honey mixing, keeps the temperature 3-5 h, using water as solvent after cooling, with ultrasonic wave extraction 3-6 h, After filtering be dried in vacuo to get.
The phellodendron extract, Radix Morindae Officinalis extract, the extracting method of Radix Gentianae Macrophyllae extract are：It cleans, chopping is returned with ethyl alcohol Stream extraction 3-5 times, merges extracting solution, is concentrated to give liquid extract.
The Herba Lycopi extract, tuckahoe extracts, Baical Skullcap root P.E, the extracting method of Rhizoma Kaempferiae extract are：It cleans, cuts It is broken, using water as solvent, with ultrasonic wave extraction 3-6 h, liquid extract is concentrated to give after filtering.
The eucommia ulmoides extracts, semen vaccariae extraction, Semen Astragali Complanati extract, the extracting method of Chinese torreyanut extract are：It washes Only, wheat bran fries 0.5-1 h, and temperature is 120-130 DEG C, wheat bran is filtered after cooling, using ethyl alcohol as solvent, with ultrasonic wave extraction 3- 6 h are concentrated to give liquid extract after filtering.
The licorice, flores aurantii extract, Cananga odorata extract, aloe extract are obtained by supercritical carbon dioxide extracting It arrives, extraction temperature is 30-35 DEG C, and extracting pressure is 18-25 MPa, and resolution temperature is 42-53 DEG C, and parsing pressure is 5-7 MPa。
Prescription A is by mannitol, oligopeptides -1, oligopeptides -3, Magnolia cortex P.E, Rhizoma Gastrodiae extract, Horse chest Nut P.E, strongly fragrant Golden extract, Rhizoma Sparganii extract, Radix Berberidis extract, Radix Asteris extract, Fructus Sophorae extract, angelica extract are uniformly mixed, so Solid is frozen into using freeze drier afterwards, then is dried in vacuo to obtain.
Prescription B is by water, Sensiva SC50, Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate, Herba Lycopi extraction Object, tuckahoe extracts, Baical Skullcap root P.E, kaempferia galamga extract, phellodendron extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract, Cortex Eucommiae carry Take object, semen vaccariae extraction, Semen Astragali Complanati extract, Chinese torreyanut extract, licorice, flores aurantii extract, Cananga odorata extract, Aloe extract is uniformly mixed to obtain.
The application method of the drug of a kind of above-mentioned treatment acne hole and depressed scar, by the solid and liquid object with weight Measure ratio 1：（50-75）Required position is directly applied to after mixing.
Hereinafter, the present invention is explained in more detail by embodiment, it should be appreciated that these embodiments are only Illustrate and not restrictive.It is if raw materials used to be all commercially available without other explanations.
The present invention is described in detail referring to several examples.
Embodiment 1
A kind of drug for treating acne hole and depressed scar, is made of prescription A and prescription B,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
15 parts of mannitol, 8 parts of oligopeptides -1,8 parts of oligopeptides -3,12 parts of Magnolia cortex P.E, 10 parts of Rhizoma Gastrodiae extract, sieve Suo 28 parts of seed extract, 16 parts of Radix Curcumae extract, 8 parts of Rhizoma Sparganii extract, 36 parts of Radix Berberidis extract, 16 parts of Radix Asteris extract, Chinese scholartree 10 parts of horn extraction, 6 parts of angelica extract；
Prescription A is to be frozen into solid using freeze drier after mixing by above-mentioned substance, then is dried in vacuo to obtain.
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 50 parts of Sensiva SC50,20 parts of Sodium Hyaluronate, 36 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 18 parts of extract, 8 parts of tuckahoe extracts, 8 parts of Baical Skullcap root P.E, 24 parts of kaempferia galamga extract, 12 parts of phellodendron extract, Morinda officinalis 8 parts of extract, 8 parts of Radix Gentianae Macrophyllae extract, 36 parts of eucommia ulmoides extracts, 18 parts of semen vaccariae extraction, 32 parts of Semen Astragali Complanati extract, Chinese torreya 12 parts of seed extract, 22 parts of licorice, 6 parts of flores aurantii extract, 6 parts of Cananga odorata extract, 6 parts of aloe extract.
Prescription B is to be uniformly mixed to obtain by above-mentioned substance.
The Magnolia cortex P.E, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, the extraction side of Radix Berberidis extract Method is：Clean, chopping, with acetic acid refluxing extraction 5 times, merge extracting solution, be dried in vacuo to get.
The Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, the extracting method of angelica extract are：It cleans, cuts 50 DEG C are heated to after broken and refined honey mixing, keeps the temperature 4 h, using water as solvent after cooling, with 5 h of ultrasonic wave extraction, vacuum is done Dry extracting solution to get.
The phellodendron extract, Radix Morindae Officinalis extract, the extracting method of Radix Gentianae Macrophyllae extract are：It cleans, chopping is returned with ethyl alcohol Stream extraction 5 times, merges extracting solution, is concentrated to give liquid extract.
The Herba Lycopi extract, tuckahoe extracts, Baical Skullcap root P.E, the extracting method of Rhizoma Kaempferiae extract are：It cleans, cuts It is broken, using water as solvent, with 5 h of ultrasonic wave extraction, liquid extract is concentrated to give after filtering.
The eucommia ulmoides extracts, semen vaccariae extraction, Semen Astragali Complanati extract, the extracting method of Chinese torreyanut extract are：It washes Only, wheat bran fries 40 min, and temperature is 125 DEG C, wheat bran is filtered after cooling, using ethyl alcohol as solvent, with 5 h of ultrasonic wave extraction, mistake Liquid extract is concentrated to give after filter.
The licorice, flores aurantii extract, Cananga odorata extract, aloe extract are obtained by supercritical carbon dioxide extracting It arrives, extraction temperature is 33 DEG C, and extracting pressure is 22 MPa, and resolution temperature is 45 DEG C, and parsing pressure is 6 MPa.
Embodiment 2
It is same as Example 1, the difference is that,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
13 parts of mannitol, 6 parts of oligopeptides -1,6 parts of oligopeptides -3,10 parts of Magnolia cortex P.E, 8 parts of Rhizoma Gastrodiae extract, sieve Suo 26 parts of seed extract, 14 parts of Radix Curcumae extract, 6 parts of Rhizoma Sparganii extract, 34 parts of Radix Berberidis extract, 14 parts of Radix Asteris extract, Chinese scholartree 8 parts of horn extraction, 6 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 40 parts of Sensiva SC50,16 parts of Sodium Hyaluronate, 32 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 16 parts of extract, 6 parts of tuckahoe extracts, 6 parts of Baical Skullcap root P.E, 22 parts of kaempferia galamga extract, 10 parts of phellodendron extract, Morinda officinalis 6 parts of extract, 6 parts of Radix Gentianae Macrophyllae extract, 34 parts of eucommia ulmoides extracts, 16 parts of semen vaccariae extraction, 30 parts of Semen Astragali Complanati extract, Chinese torreya 10 parts of seed extract, 20 parts of licorice, 4 parts of flores aurantii extract, 4 parts of Cananga odorata extract, 4 parts of aloe extract.
Embodiment 3
It is same as Example 1, the difference is that,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
11 parts of mannitol, 4 parts of oligopeptides -1,4 parts of oligopeptides -3,8 parts of Magnolia cortex P.E, 6 parts of Rhizoma Gastrodiae extract, buckeye 24 parts of extract, 12 parts of Radix Curcumae extract, 4 parts of Rhizoma Sparganii extract, 32 parts of Radix Berberidis extract, 12 parts of Radix Asteris extract, the Fructus Sophorae 6 parts of extract, 4 parts of angelica extract；
Prescription B is liquid form, and the parts by weight of material composition and each substance in the prescription are：
100 parts of water, 35 parts of Sensiva SC50,14 parts of Sodium Hyaluronate, 28 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 14 parts of extract, 4 parts of tuckahoe extracts, 4 parts of Baical Skullcap root P.E, 20 parts of kaempferia galamga extract, 8 parts of phellodendron extract, Morinda officinalis 4 parts of extract, 4 parts of Radix Gentianae Macrophyllae extract, 32 parts of eucommia ulmoides extracts, 14 parts of semen vaccariae extraction, 28 parts of Semen Astragali Complanati extract, Chinese torreya 8 parts of seed extract, 18 parts of licorice, 2 parts of flores aurantii extract, 2 parts of Cananga odorata extract, 2 parts of aloe extract.
Embodiment 4
It is same as Example 1, the difference is that,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
17 parts of mannitol, 10 parts of oligopeptides -1,10 parts of oligopeptides -3,14 parts of Magnolia cortex P.E, 12 parts of Rhizoma Gastrodiae extract, Suo 30 parts of sieve seed extract, 18 parts of Radix Curcumae extract, 10 parts of Rhizoma Sparganii extract, 38 parts of Radix Berberidis extract, 18 parts of Radix Asteris extract, 12 parts of Fructus Sophorae extract, 10 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 60 parts of Sensiva SC50,24 parts of Sodium Hyaluronate, 40 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 20 parts of extract, 10 parts of tuckahoe extracts, 10 parts of Baical Skullcap root P.E, 26 parts of kaempferia galamga extract, 14 parts of phellodendron extract, Morinda offcinalis How 10 parts of its extract, 10 parts of Radix Gentianae Macrophyllae extract, 38 parts of eucommia ulmoides extracts, 20 parts of semen vaccariae extraction, Semen Astragali Complanati extract 34 Part, 14 parts of Chinese torreyanut extract, 24 parts of licorice, 8 parts of flores aurantii extract, 8 parts of Cananga odorata extract, 8 parts of aloe extract.
Embodiment 5
It is same as Example 1, the difference is that,
The parts by weight of the material composition of prescription A and each substance in the prescription are：
19 parts of mannitol, 12 parts of oligopeptides -1,12 parts of oligopeptides -3,16 parts of Magnolia cortex P.E, 14 parts of Rhizoma Gastrodiae extract, Suo 32 parts of sieve seed extract, 20 parts of Radix Curcumae extract, 12 parts of Rhizoma Sparganii extract, 40 parts of Radix Berberidis extract, 20 parts of Radix Asteris extract, 14 parts of Fructus Sophorae extract, 12 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 65 parts of Sensiva SC50,26 parts of Sodium Hyaluronate, 44 parts of saccharomycetes to make fermentation lysate filtrate, pool Blue 22 parts of extract, 12 parts of tuckahoe extracts, 12 parts of Baical Skullcap root P.E, 28 parts of kaempferia galamga extract, 16 parts of phellodendron extract, Morinda offcinalis How 12 parts of its extract, 12 parts of Radix Gentianae Macrophyllae extract, 40 parts of eucommia ulmoides extracts, 22 parts of semen vaccariae extraction, Semen Astragali Complanati extract 36 Part, 16 parts of Chinese torreyanut extract, 26 parts of licorice, 10 parts of flores aurantii extract, 10 parts of Cananga odorata extract, aloe extract 10 Part.
Comparative example 1
It is same as Example 1, the difference is that the material composition of prescription A is free of Radix Berberidis extract.
Comparative example 2
It is same as Example 1, the difference is that the material composition of prescription A is free of Horse chest Nut P.E.
Comparative example 3
It is same as Example 1, the difference is that the material composition of prescription B is free of Semen Astragali Complanati extract.
Comparative example 4
It is same as Example 1, the difference is that the material composition of prescription B is free of eucommia ulmoides extracts.
Comparative example 5
It is same as Example 1, the difference is that the material composition of prescription A is free of Radix Asteris extract.
Comparative example 6
It is same as Example 1, the difference is that the material composition of prescription B is free of kaempferia galamga extract.
Comparative example 7
It is same as Example 1, the difference is that the material composition of prescription A is free of Magnolia cortex P.E.
Comparative example 8
It is same as Example 1, the difference is that, the extracting method of Radix Berberidis extract is：Using water as solvent, with super Sound wave extracts 5 h, and liquid extract is concentrated to give after filtering.
Comparative example 9
It is same as Example 1, the difference is that, the extracting method of Horse chest Nut P.E is：It cleans, ethyl alcohol is used in chopping Refluxing extraction 5 times merges extracting solution, is concentrated to give liquid extract.
Comparative example 10
It is same as Example 1, the difference is that, the extracting method of Semen Astragali Complanati extract is：It cleans, ethyl alcohol is used in chopping Refluxing extraction 5 times merges extracting solution, is concentrated to give liquid extract.
Comparative example 11
It is same as Example 1, the difference is that, the extracting method of eucommia ulmoides extracts is：It cleans, chopping is returned with ethyl alcohol Stream extraction 5 times, merges extracting solution, is concentrated to give liquid extract.
Evaluation method
Select 160 volunteers, male 16 people of the age between 18-25 Sui, 16 people of women；Age is 26-30 year Between 16 people of male, 16 people of women；Male 16 people of the age between 31-35 Sui, 16 people of women；Age is between 36-40 Sui 16 people of male, 16 people of women；Male 16 people of the age between 41-45 Sui, 16 people of women.The volunteer's face selected is There is acne to cheat or depressed scar, and do not have in previous month of test using any treatment acne hole or depressed scar Product.It is 1-16 groups by 160 volunteer's lacings, every group of 10 people, each 1 people of men and women of the age between 18-25 Sui, the age exists Each 1 people of men and women between 26-30 Sui, each 1 people of men and women of the age between 31-35 Sui, the age, the men and women between 36-40 Sui was each 1 people, each 1 people of men and women of the age between 41-45 Sui.
1-5 groups are respectively using embodiment 1-5, and 6-16 groups are respectively using comparative example 1-11, daily each use in the morning, afternoon and evening Once, 16 mg of prescription A, 1 g of prescription B are taken during use, is directly applied to after mixing on acne hole and depressed scar, even It is continuous uninterruptedly to use 180 days.
Opinion rating is divided into A, and acne hole and depressed scar completely disappear；It is left that B, acne hole and depressed scar mitigate 80 % It is right；C, acne hole and depressed scar mitigate 30 % or so；D, acne hole and depressed scar do not change.
Treatment results see the table below.
Group A B C D
1st group 9 1 0 0
2nd group 7 2 1 0
3rd group 8 1 1 0
4th group 8 2 0 0
5th group 7 1 2 0
6th group 0 2 4 4
7th group 0 3 4 3
8th group 0 2 3 5
9th group 0 2 4 4
10th group 5 3 2 0
11st group 4 3 3 0
12nd group 5 3 2 0
13rd group 2 4 3 1
14th group 1 3 4 2
15th group 0 4 2 4
16th group 0 3 5 2
From test result as can be seen that a kind of acne hole and the drug of depressed scar for the treatment of provided by the invention can promote Defective tissue cytothesis is conducive to the growth of cell at skin depressions.It is effectively improved the acne of the people of 18-45 Sui each age level Hole and depressed scar, while hormone is not contained, it is environmentally protective, provide beneficial effect.
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the scope of the present invention.It is every The equivalent changes and modifications that content is done according to the present invention are encompassed by the scope of the claims of the present invention.

Claims (9)

1. a kind of drug for treating acne hole and depressed scar, which is characterized in that be made of prescription A and prescription B, prescription A is solid Volume morphing, the parts by weight of material composition and each substance in the prescription are：
11-19 parts of mannitol, -1 4-12 parts of oligopeptides, -3 4-12 parts of oligopeptides, 8-16 parts of Magnolia cortex P.E, Rhizoma Gastrodiae extract 6- 14 parts, 24-32 parts of Horse chest Nut P.E, 12-20 parts of Radix Curcumae extract, 4-12 parts of Rhizoma Sparganii extract, Radix Berberidis extract 32-40 Part, 12-20 parts of Radix Asteris extract, 6-14 parts of Fructus Sophorae extract, 4-12 parts of angelica extract；
Prescription B is liquid form, and the parts by weight of material composition and each substance in the prescription are：
100 parts of water, 35-65 parts of Sensiva SC50,14-26 parts of Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate 28-44 Part, 14-22 parts of Herba Lycopi extract, 4-12 parts of tuckahoe extracts, 4-12 parts of Baical Skullcap root P.E, 20-28 parts of kaempferia galamga extract, Cortex Phellodendri 8-16 parts of extract, 4-12 parts of Radix Morindae Officinalis extract, 4-12 parts of Radix Gentianae Macrophyllae extract, 32-40 parts of eucommia ulmoides extracts, the seed of cowherb carry Take 14-22 parts of object, 28-36 parts of Semen Astragali Complanati extract, 8-16 parts of Chinese torreyanut extract, 18-26 parts of licorice, flores aurantii extract 2-10 parts, 2-10 parts of Cananga odorata extract, 2-10 parts of aloe extract.
2. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that
The parts by weight of the material composition of prescription A and each substance in the prescription are：
13-17 parts of mannitol, -1 6-10 parts of oligopeptides, -3 6-10 parts of oligopeptides, 10-14 parts of Magnolia cortex P.E, Rhizoma Gastrodiae extract 8-12 parts, 26-30 parts of Horse chest Nut P.E, 14-18 parts of Radix Curcumae extract, 6-10 parts of Rhizoma Sparganii extract, Radix Berberidis extract 34- 38 parts, 14-18 parts of Radix Asteris extract, 8-12 parts of Fructus Sophorae extract, 6-10 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 40-60 parts of Sensiva SC50,16-24 parts of Sodium Hyaluronate, saccharomycetes to make fermentation lysate filtrate 32-40 Part, 16-20 parts of Herba Lycopi extract, 6-10 parts of tuckahoe extracts, 6-10 parts of Baical Skullcap root P.E, 22-26 parts of kaempferia galamga extract, Cortex Phellodendri 10-14 parts of extract, 6-10 parts of Radix Morindae Officinalis extract, 6-10 parts of Radix Gentianae Macrophyllae extract, 34-38 parts of eucommia ulmoides extracts, the seed of cowherb 16-20 parts of extract, 30-34 parts of Semen Astragali Complanati extract, 10-14 parts of Chinese torreyanut extract, 20-24 parts of licorice, flores aurantii carry Take 4-8 parts of object, 4-8 parts of Cananga odorata extract, 4-8 parts of aloe extract.
3. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that
The parts by weight of the material composition of prescription A and each substance in the prescription are：
15 parts of mannitol, 8 parts of oligopeptides -1,8 parts of oligopeptides -3,12 parts of Magnolia cortex P.E, 10 parts of Rhizoma Gastrodiae extract, buckeye carry 28 parts of object, 16 parts of Radix Curcumae extract, 8 parts of Rhizoma Sparganii extract, 36 parts of Radix Berberidis extract, 16 parts of Radix Asteris extract, the Fructus Sophorae is taken to carry Take 10 parts of object, 6 parts of angelica extract；
The parts by weight of the material composition of prescription B and each substance in the prescription are：
100 parts of water, 50 parts of Sensiva SC50,20 parts of Sodium Hyaluronate, 36 parts of saccharomycetes to make fermentation lysate filtrate, Herba Lycopi carry Take 18 parts of object, 8 parts of tuckahoe extracts, 8 parts of Baical Skullcap root P.E, 24 parts of kaempferia galamga extract, 12 parts of phellodendron extract, Morinda officinalis extraction 8 parts of object, 8 parts of Radix Gentianae Macrophyllae extract, 36 parts of eucommia ulmoides extracts, 18 parts of semen vaccariae extraction, 32 parts of Semen Astragali Complanati extract, Chinese torreyanut carry Take 12 parts of object, 22 parts of licorice, 6 parts of flores aurantii extract, 6 parts of Cananga odorata extract, 6 parts of aloe extract.
4. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that the Magnolia cortex P.E, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, the extracting method of Radix Berberidis extract are：It cleans, chopping is returned with acetic acid Stream extraction 3-5 time, merging extracting solution, be dried in vacuo to get.
5. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that the buckeye extraction Object, Radix Asteris extract, Fructus Sophorae extract, the extracting method of angelica extract are：It cleans, is heated to after chopping and refined honey mixing 45-65 DEG C, keep the temperature 3-5h, using water as solvent after cooling, with ultrasonic wave extraction 3-6h, after filtering vacuum drying to get.
6. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that the phellodendron extract, Radix Morindae Officinalis extract, the extracting method of Radix Gentianae Macrophyllae extract are：It cleans, chopping is extracted 3-5 times with alcohol reflux, merges extracting solution, It is concentrated to give liquid extract.
7. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that the Herba Lycopi extract, Tuckahoe extracts, Baical Skullcap root P.E, the extracting method of Rhizoma Kaempferiae extract are：It cleans, chopping using water as solvent, uses ultrasonic wave 3-6h is extracted, liquid extract is concentrated to give after filtering.
8. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that the eucommia ulmoides extracts, Semen vaccariae extraction, Semen Astragali Complanati extract, the extracting method of Chinese torreyanut extract are：It cleans, wheat bran fries 0.5-1h, and temperature is 120-130 DEG C, wheat bran is filtered after cooling, shreds, using ethyl alcohol as solvent, with ultrasonic wave extraction 3-6h, is concentrated to give after filtering Liquid extract.
9. the drug for the treatment of acne hole and depressed scar as described in claim 1, which is characterized in that the licorice, Flores aurantii extract, Cananga odorata extract, aloe extract are obtained by supercritical carbon dioxide extracting, and extraction temperature is 30-35 DEG C, extraction Pressure power is 18-25MPa, and resolution temperature is 42-53 DEG C, and parsing pressure is 5-7MPa.
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CN107308440A (en) * 2017-06-01 2017-11-03 李博 Dispel striae of pregnancy, scar reparation, anti-wrinkle Skin whitening care cosmeticses and preparation method thereof
CN107596360A (en) * 2017-10-10 2018-01-19 苏州浔宇新材料科技有限公司 A kind of pharmaceutical composition for repairing scar and preparation method thereof
CN111494393B (en) * 2019-01-30 2021-05-07 中国科学院微生物研究所 Preparation method and application of poria peel triterpene composition
CN115554386B (en) * 2022-11-03 2023-05-19 通化仁生源生物科技股份有限公司 Application of gastrodia elata polypeptide in preparing external product for inhibiting or killing trichophyton

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