CN108096356B

CN108096356B - Mild wound disinfectant and application thereof

Info

Publication number: CN108096356B
Application number: CN201810124650.5A
Authority: CN
Inventors: 不公告发明人
Original assignee: Nantong Dongkang Medical Science And Technology Co ltd
Current assignee: Nantong Dongkang Medical Science And Technology Co ltd
Priority date: 2018-02-07
Filing date: 2018-02-07
Publication date: 2020-12-18
Anticipated expiration: 2038-02-07
Also published as: CN108096356A

Abstract

The invention relates to the field of new technologies, in particular to a mild wound disinfection solution and application thereof. The mild wound disinfectant comprises raw materials for preparing garden burnet, golden cypress, herba lycopi, safflower, rheum officinale, sappan wood, rosewood, dandelion, purslane, hawthorn, honeysuckle, radix angelicae, angelica and radix scutellariae. Has good antibacterial and bactericidal effects on bacteria which are easy to infect wounds, such as staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and the like, and can avoid infection of wounds. Moreover, the raw materials for preparing the mild wound disinfectant are all natural plants, and the allergy of the obtained wound disinfectant to the wound can be avoided by extracting the mild wound disinfectant through the specific combination and method among the specific plant raw materials.

Description

Mild wound disinfectant and application thereof

Technical Field

The invention relates to the field of new technologies, in particular to a mild wound disinfection solution and application thereof.

Background

In daily life, due to surgery or other reasons, people inevitably suffer from traumatic wounds, which if not actively and effectively treated, are likely to cause wound infection, thereby affecting the wound healing process. The infected wound not only increases the pain of the patient, obviously prolongs the hospitalization time of the patient, influences the prognosis of the patient, but also increases the medical cost of the patient and even causes medical disputes. In real life, when people suffer from abrasion, puncture, scald and other conditions, disinfectants such as alcohol, iodine tincture, iodophor, gentian violet and the like are generally used for disinfection. The principle of alcohol disinfection is that the sterilization effect is achieved by destroying alcohol and solidifying bacteria, and because alcohol has strong irritation, the alcohol is generally only used for disinfecting skin around wounds and cannot be directly applied to the wounds. Otherwise, the wound is stimulated, pain is difficult to suffer, wound surface protein is solidified, and wound healing is influenced. The principle of iodine disinfection is that iodine element can be directly combined with amino group to destroy protein and enzyme and make microorganism die. However, iodine tincture cannot be applied to wounds, and the patients should be treated with alcohol as soon as possible after the iodine tincture is applied, so that the skin of the patients is prevented from being burnt. The iodophor is a common disinfectant, has small irritation to skin, has no corrosion effect, and can form a protective film to prevent bacterial reinfection. Patients allergic to iodine should be contraindicated. The gentian violet is used as gentian violet in medicine, has the functions of sterilizing and promoting scab formation, and is mainly used for wound infection and fungal infection of skin and mucous membrane. The gentian violet is fast in convergence and scabbing, so that the gentian violet is not suitable for deeper wounds and dirtier wounds, otherwise, pus is easily accumulated under scabs, the gentian violet is not suitable for puncture wounds and the like, and the gentian violet cannot play a good disinfection role for wounds caused by diabetes and the like.

Disclosure of Invention

In view of the above technical problems, the first aspect of the present invention provides a mild wound disinfectant, which is prepared from raw materials including sanguisorba officinalis, phellodendron amurense, herba lycopi, safflower, rheum officinale, sappan wood, dalbergia wood, dandelion, purslane, hawthorn, honeysuckle, radix angelicae, angelica sinensis and radix scutellariae.

As a preferable technical scheme, the mild wound disinfectant comprises, by weight, 15-50 parts of sanguisorba, 20-45 parts of golden cypress, 17-33 parts of herba lycopi, 22-35 parts of safflower, 20-30 parts of rheum officinale, 15-27 parts of sappan wood, 18-45 parts of lignum dalbergiae odoriferae, 18-30 parts of dandelion, 20-32 parts of purslane, 20-33 parts of hawthorn, 20-35 parts of honeysuckle, 20-38 parts of radix angelicae, 18-30 parts of angelica sinensis and 18-35 parts of scutellaria baicalensis.

As a preferable technical scheme, the mild wound disinfectant comprises, by weight, 24-45 parts of sanguisorba, 28-32 parts of phellodendron, 20-26 parts of herba lycopi, 28-32 parts of safflower, 20-26 parts of rheum officinale, 16-22 parts of sappan wood, 26-38 parts of rosewood, 20-26 parts of dandelion, 23-27 parts of purslane, 22-27 parts of hawthorn, 22-28 parts of honeysuckle, 23-29 parts of radix angelicae, 20-27 parts of angelica sinensis and 20-28 parts of scutellaria baicalensis.

As a preferred technical scheme, the mild wound disinfection solution also comprises 20-26 parts by weight of arnebia euchroma.

As a preferable technical scheme, the mild wound disinfectant comprises, by weight, 38 parts of sanguisorba officinalis, 31 parts of phellodendron, 24 parts of herba lycopi, 27 parts of safflower, 23 parts of rheum officinale, 20 parts of sappan wood, 35 parts of dalbergia wood, 24 parts of dandelion, 25 parts of purslane, 25 parts of hawthorn, 26 parts of honeysuckle, 26 parts of radix angelicae, 24 parts of angelica sinensis, 25 parts of radix scutellariae and 24 parts of arnebia euchroma.

The second aspect of the present invention provides a preparation method of the mild wound disinfection solution, which at least comprises the following steps:

(1) oven drying lignum sappan, radix Sangusorbae, flos Lonicerae and herba Lycopi, pulverizing, adding 50wt% ethanol water solution, heating and refluxing, filtering, and concentrating the filtrate to obtain viscous substance A;

(2) taking radix scutellariae and rheum officinale in required weight, drying and crushing, adding 75wt% ethanol water solution, stirring, mixing, performing microwave extraction, filtering, and concentrating the filtrate to obtain B;

(3) drying and crushing the hawthorn and the masson grass in required weight, adding 60wt% of ethanol water solution and 0.5-2.5 wt% of dispersant, stirring and mixing, then performing ultrasonic extraction at the power of 250w, filtering, and concentrating the filtrate to obtain C;

(4) drying and crushing safflower and angelica sinensis with required weight, adding distilled water, heating and refluxing, filtering, concentrating the filtrate to obtain D, and drying the filter residue to obtain extract powder; drying and crushing cortex phellodendri, adding the extracted powder, 1-3 wt% of an auxiliary agent and 80wt% of an ethanol aqueous solution, heating, refluxing, filtering, and concentrating the filtrate to obtain E;

(5) adding distilled water into the angelica dahurica with the required weight, heating and refluxing, filtering, and concentrating the filtrate to obtain F; drying the filter residue, adding dandelion, dalbergia wood and ethanol with required weight into the dried powder, heating and refluxing, centrifuging, precipitating and filtering, and concentrating the filtrate to obtain G;

(6) and (3) blending the A, B, C, D, E, F and G obtained in the steps (1) to (5), adding medical alcohol and distilled water for dilution, and performing aseptic treatment to obtain the mild wound disinfectant.

As a preferred technical scheme of the invention, arnebia euchroma (Royle) Johnst is also added in the process of extracting the radix scutellariae and the rhubarb in the step (2).

In a preferred embodiment of the present invention, the dispersant in step (3) is one or more selected from polyethylene glycol, gelatin, and cellulose derivatives.

In a preferred embodiment of the present invention, the auxiliary in step (4) is one or more selected from anhydrous sodium sulfate, anhydrous magnesium sulfate, and sodium chloride.

The third aspect of the invention provides application of the mild wound disinfectant prepared by the preparation method of the mild wound disinfectant, wherein the mild wound disinfectant is applied to disinfection of wounds caused by abrasion, laceration, cut wound, puncture, burn and diabetes.

Advantageous effects: compared with the prior art, the mild wound disinfectant provided by the application does not contain components such as antibiotics, the preparation raw materials are all natural plants, and the finally obtained wound disinfectant has good bacteriostatic and bactericidal effects on bacteria which are easy to infect wounds, such as staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and the like, through compounding among various natural plants, a specific preparation method and the synergistic effect among the components. In addition, the wound disinfectant with good pit allergy is obtained by adopting a specific extraction method through the compatibility of specific components. Secondly, the mild wound disinfectant provided by the application is simple in preparation method, durable in antibacterial action, free of toxic and side effects on wounds and human bodies, and free of pollution to the environment. The obtained wound disinfectant has good application in the fields of bruise, laceration, cut wound, puncture wound, burn, wound caused by diabetes and the like.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The generic term "polymer" embraces the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer".

"interpolymer" means a polymer prepared by polymerizing at least two different monomers. The generic term "interpolymer" includes the term "copolymer" (which is generally used to refer to polymers prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to polymers prepared from three different monomers). It also includes polymers made by polymerizing four or more monomers. "blend" means a polymer formed by two or more polymers being mixed together by physical or chemical means.

In order to solve the technical problems, in a first aspect of the invention, a mild wound disinfectant is provided, and raw materials for preparing the mild wound disinfectant comprise sanguisorba, phellodendron, herba lycopi, safflower, rheum officinale, sappan wood, dalbergia wood, dandelion, purslane, hawthorn, honeysuckle, angelica dahurica, angelica and radix scutellariae.

In a preferred embodiment, the mild wound disinfectant comprises, by weight, 15-50 parts of sanguisorba officinalis, 20-45 parts of phellodendron, 17-33 parts of herba lycopi, 22-35 parts of safflower, 20-30 parts of rheum officinale, 15-27 parts of sappan wood, 18-45 parts of rosewood, 18-30 parts of dandelion, 20-32 parts of purslane, 20-33 parts of hawthorn, 20-35 parts of honeysuckle, 20-38 parts of radix angelicae, 18-30 parts of angelica sinensis and 18-35 parts of scutellaria baicalensis.

In a preferred embodiment, the mild wound disinfectant comprises, by weight, 24-45 parts of sanguisorba officinalis, 28-32 parts of phellodendron, 20-26 parts of herba lycopi, 28-32 parts of safflower, 20-26 parts of rheum officinale, 16-22 parts of sappan wood, 26-38 parts of rosewood, 20-26 parts of dandelion, 23-27 parts of purslane, 22-27 parts of hawthorn, 22-28 parts of honeysuckle, 23-29 parts of radix angelicae, 20-27 parts of angelica sinensis and 20-28 parts of scutellaria baicalensis.

The sanguisorba officinalis in the invention is dried root of sanguisorba officinalis or sanguisorba longifolia which is a perennial herb of Rosaceae. All produced in China. Collected in spring and autumn, sliced, dried in the sun, unprocessed or stir-baked into charcoal. Contains triterpene and other glycosides, such as sanguisorba glycoside I, II, III, etc., and contains gallic acid tannin and condensed tannin, gallic acid, ellagic acid, etc. Can shorten blood coagulation time and shrink blood vessel, thereby having hemostatic effect; has therapeutic effect on experimental scald; the in vitro antibacterial test has effects on Staphylococcus aureus, Pseudomonas aeruginosa, Shigella shigella, typhoid bacillus, paratyphoid bacillus, human type tubercle bacillus and some pathogenic fungi; it also has antiinflammatory, experimental diarrhea resisting, and tranquilizing effects.

Cortex Phellodendri is the dried bark of phellodendron amurense or phellodendron amurense belonging to the genus phellodendron of the family Rutaceae, the former is commonly called "phellodendron amurense" and the latter is commonly called "phellodendron amurense" of the family Rutaceae. Modern scientific research shows that: cortex Phellodendri contains a large amount of bioactive components, such as alkaloid, sterol, lactone and mucus. Alkaloid is the most important active substance in phellodendron, and the currently discovered components comprise berberine, phellodendrine, jateorhizine, dauricine, tetrandrine, magnoflorine, N-methyl hordenine and the like. In addition, cortex Phellodendri contains other active substances, such as phellodendron lactone, obacunone, 7-dehydrostigmasterol, campesterol, green fluorescent acid, beta-sitosterol, obacunone acid and dictamnolide.

Herba Lycopi, also called as Gekko Swinhonis seedling, rhizoma Lycopi, semen mannocarotis, and herba Lycopi Farfarae, is the dry aerial part of Gekko Swinhonis seedling of Labiatae. Collected in summer and autumn when stems and leaves are flourishing, dried in the sun, and the whole plant can be used as medicine. The eupatorium adenophorum is in a square column shape, has few branches, has shallow longitudinal ditches on four sides, is 50-100 cm long, and has a diameter of 0.2-0.6 cm. The surface is yellow green or green, the joints are purple and obvious, and white fuzz exists; brittle, yellowish white cross section, and hollow pulp. The leaves are opposite and have short stalks; the blades are more wrinkled and are in a needle-shaped or long round shape after being flattened, and the length of the blades is 5-10 cm; the upper surface is dark green, the lower surface is gray green, the gland points are densely arranged, and both surfaces are provided with short hairs; the front end is sharp and the edge is provided with sawteeth. The axils of the flowers and the leaves are wheel-shaped, the corolla is mostly fallen off, bracts and calyx are reserved, and the flowers and the leaves are yellow brown, odorless and light in taste. The rhizoma et radix Diphylleiae seedling contains volatile oil, glucoside, tannin and resin, and also contains flavonoid glycoside, phenols, amino acids, organic acids, saponin, glucose, galactose, eupatorium japonicum sugar, sucrose, raffinose, stachyose, fructose, glucose, galactose, eupatorium japonicum sugar, sucrose, raffinose, stachyose, caffeic acid, rosmarinic acid, betulinic acid, flavonoids compounds, phenolic acid compounds, triterpenic acid compounds and other components.

Safflower, alias: carthamus tinctorius flower, Carthamus tinctorius flower of Compositae, Carthamus, dried tubular flower, orange red, narrow and thin floral tube, 5-split tip, narrow-slit shape, and yellow anther, which are combined into tube, higher than the split, with its stigma exposed at the center. Has special fragrance and slightly bitter taste. The preferred one is long, bright red, soft. The Carthami flos contains carthamin, pre-carthamin, safflower yellow A and B, and carthamin A. And also polyphenol components, such as: chlorogenic acid, caffeic acid, catechol, pyrocatechol, and dopa. And further comprises volatile components of eighty or more species, such as ethyl acetate, benzene, 1-penten-3-ol, 3-hexanol, 2-hexanol, (E) -2-hexenal, 3-methylbutyric acid, 2-methylbutyric acid, ethylbenzene, p-xylene, o-xylene, phenylacetaldehyde, nonanal, terpinen-4-ol, mazinone, decanal, benzothiazole, (E, E) -2, 4-decadienal, methyl cinnamate, 1,2, 3-trimethoxy-5-methylbenzene, alpha- (royal) (wangu) ene, 1-ditetracarbene, alpha-cedrene, caryophyllene, (E) -beta-farnesene, humulene, beta-ionone, beta-apiecene, dihydroactinidiolide, 1-pentadecene, -pipercubene, caryophyllene epoxide, 1-hexadecene, beta-sitosterol, palmitic acid, myristic acid, lauric acid, alpha, gamma-dipalmitin, oleic acid, linoleic acid, beta-sitosterol-3-O-glucoside and the like. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain. Has the effects of promoting blood circulation, stimulating the menstrual flow, dissipating blood stasis, relieving pain and the like.

Rhubarb is the name of perennial plants of rhubarb of Polygonaceae and also the name of Chinese medicinal materials, and the invention uses rhizome as medicine. Rhubarb is often referred to in the literature in Chinese areas as rheum palmatum. The radix et rhizoma Rhei powder is rich in anthraquinone compounds such as rhein, emodin, aloe-emodin, chrysophanol, and physcion.

Lignum sappan, iso-name Su balk, Su Fang mu, Chimu, and Red firewood, which are the dry heartwood of lignum sappan of Leguminosae. The method is mainly distributed in places such as Guangxi, Guangdong, Taiwan, Guizhou, Yunnan, Sichuan and the like in China. Collected all the year round, the outer skin and the edge material are removed, the core material is taken and dried in the sun. The drug property is sweet, salty, mild and nontoxic. The chemical components of the compound comprise 1-hydroxy-7-methoxyl xanthone, 2-hydroxyl xanthone, 1, 5-dyhydroxyl xanthone, 1, 7-dyhydroxyl xanthone, chrysophanol, friedelin, ursolic acid, beta-sitosterol palmitate, stigmasterol, beta-sitosterol and the like. Can be used for treating traumatic injury, tetanus, dysmenorrhea, puerperal blood stasis, cardialgia, puerperal blood faint, carbuncle, swelling, etc. It has expectorant, repercussive, analgesic, blood circulation promoting, blood stasis dispelling, and pathogenic wind expelling effects.

Lignum Dalbergiae Odoriferae, also called rosewood and Dalbergia odorifera, is tall 10-15 m and has small and dense bark holes in small branches. The length of the pinnate compound leaf is 12-25 cm. The dalbergia wood, pungent in flavor and pungent in flavor, has the effects of warming and dredging, entering liver meridian, and descending blood, has the functions of removing stasis, stopping bleeding and relieving pain, and has the effects on traumatic injury, blood stasis and swelling pain, internal and external bleeding, and both oral administration and external application. Internal bleeding stopping is achieved based on blood stasis, so it is not suitable for patients with internal bleeding without blood stasis.

Herba Taraxaci of Compositae, herba Taraxaci of alias herba Violae, herba Veronicae Didyma, HUALANG, etc. Perennial herb of Compositae. The dandelion has the effects of clearing away heat and toxic materials, relieving swelling, resolving hard mass, inducing diuresis and treating stranguria. The name of the prescription: dandelion, fresh dandelion and herba violae. The dandelion plant contains various health nutritional components such as taraxol, taraxacin, choline, organic acid, inulin, etc.

Purslane is an annual fleshy herbaceous plant of Portulaca in Portulacaceae, widely distributed in temperate and tropical regions, is the most common plant in China and is a plant for both food and medicine. The chemical components of the compound comprise norepinephrine, potassium salt, dopa, dopamine, betanin, isobetanin, beet type, isobetanin, oxalic acid, malic acid, citric acid, glutamic acid, aspartic acid, alanine, glucose, fructose, sucrose and the like. Can be used for treating heat toxin and bloody dysentery, carbuncle, furuncle, eczema, erysipelas, snake and insect bite, hematochezia, hemorrhoidal bleeding, metrorrhagia, metrostaxis, etc. Has effects of clearing away heat and toxic materials, relieving swelling, stopping bleeding, and cooling blood.

Crataegus pinnatifida is a plant of Crataegus of Rosaceae, more than 140 plants of Crataegus worldwide, and 17 varieties of 2 varieties are recorded in Chinese plant records. Flavonoid, procyanidine, tripalmonic acid, etc. are the main bioactive components in hawthorn. At present, more than 60 flavonoid compounds are separated from hawthorn and mainly comprise glycosides taking apigenin and luteolin as aglycones and flavonol and oxygen glycoside substances taking rutin, hyperin and quercetin as main components. The hawthorn of the present invention may use its fruit or leaf as an active ingredient.

Honeysuckle flower, also known as honeysuckle flower. Honeysuckle is named because honeysuckle flowers turn white at first and turn yellow later. The flos Lonicerae is dried bud or flower with initial blossom of Lonicera Japonica of Lonicera of Caprifoliaceae and plants of the same genus. The chemical components of the compound comprise luteolin, inositol, saponin, chlorogenic acid, isochlorogenic acid, linalool, pinene, 1-hexene, cis-3-hexenol-1, cis-2-methyl-2-vinyl-5, trans-2-methyl-2-vinyl-5, geraniol, alpha-terpineol, benzyl alcohol, phenethyl alcohol, carvacrol, eugenol and the like. Can be used for treating enteritis, bacillary dysentery, measles, pneumonia, encephalitis B, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, skin pruritus, carbuncle, cellulitis, furuncle, erysipelas, parotitis, and suppurative tonsillitis. Has effects of resisting inflammation, clearing away heat and toxic materials, and treating wind due to topical deficiency.

Radix Angelicae Dahuricae is a perennial herb with a height of 1-2.5 m, a cylindrical root with a base diameter of 2-5 cm, a basal leaf with a pinnate division, a multiple umbelliform inflorescence growing on the top or on the side, and a long fruit with a shape of oval to a oval. The root is used as a medicine and has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like. It can be used for treating wind-cold type common cold, headache, rhinitis, toothache, leucorrhea with red and white discharge, furuncle, and toxic swelling, and can also be used as perfume. Typically under the forest, at the forest edge, beside the stream, in shrubs and on the valley grassland. The water-soluble extract of radix Angelicae Dahuricae contains palmitic acid, stigmasterol, beta-sitosterol, beta-carotene, etc.; the fat-soluble extract contains coumarins such as Angelica sinensis, bergapten, umbelliferone, etc.

Dang Gui, root of Angelica sinensis Diels of Umbelliferae, can be used as a medicine. The property of the medicine is sweet, pungent and warm. The chemical components comprise volatile oil, organic acid and urine purine, wherein the organic acid comprises ferulic acid, nicotinic acid, succinic acid, vanillic acid, tetracosanoic acid, palmitic acid and the like. Can be used for treating traumatic injury, amenorrhea, dysmenorrhea, abdominal mass, metrorrhagia, skin numbness, dysentery, carbuncle, skin ulcer, etc. Has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, smoothing intestine, relieving inflammation, and enhancing immunity. In the invention, the root of Chinese angelica is used as the medicine. The radix Angelicae sinensis contains coumarins such as dihydrofurocoumarin derivative, angustifolia furocoumarin, and pyranocoumarin; flavonoid compounds such as luteolin and rutin glycoside; organic acids such as nicotinic acid and vanillic acid; chemical components such as phthalides compounds such as alloocimene, phthalides, p-cresol, etc.

Scutellariae radix, also known as radix Camelliae Japonicae and radix Tujin tea, is a perennial herb of Scutellaria of Labiatae; fleshy rhizome is fat, leaves are solid and paper, the shape of the rootstock is from needle to linear, the general inflorescence is terminal on stems and branches, the corolla is purple, purplish red to blue, the filament is flat, the style is slender, the flower disc is annular, the ovary is brown, the small nut is in the shape of an egg ball, and the period of the flower is 7-9 months. The scutellaria contains flavonoid compounds: baicalein, i.e., baicalein II, baicalin, wogonin, oroxin A, 7-methoxybaicalein, baicalein, dihydrooroxin A, chrysin, 2,5, 8-trihydroxy-7-methoxyflavone, 2,5, 8-trihydroxy-6, 7-dimethoxyflavone, 4,5, 7-trihydroxy-6-methoxyflavanone, 2,3,5,6, 7-pentahydroxyflavanone, wogonin-5-beta-D-glucoside, 2- (3-hydroxy-4-methoxyphenyl) -ethyl-1-O-alpha-L-rhamnosyl (1 → 3) -beta-D (4-feruloyl) -glucose, chrysin-6-C-alpha-L-arabinoside, chrysin-6-C-alpha-L-arabinoside-8-C-beta-D-glucoside, 5,7, 2-trihydroxy methoxyl flavone, 5,7,2, 3-tetrahydroxy flavone, etc.

In a preferred embodiment, the mild wound disinfectant also comprises 20-26 parts by weight of arnebia euchroma.

The Sinkiang arnebia root of the invention: it is the dried heel of arnebia euchroma (Royle) Johnst of Boraginaceae. Sinkiang is the main production area of arnebia euchroma (Royle) Johnst in China, 70% of raw materials in arnebia euchroma (Royle) Johnst are from arnebia euchroma (Royle) Johnst, and the annual output of Sinkiang (Sinkiang) Johnst can reach up to 200 tons. Sinkiang radix Arnebiae is rich in naphthoquinone pigment, polysaccharide, phenols, acids, etc. such as shikonin and its derivatives. The applicant finds that the extraction effect of the arnebia euchroma (Royle) Johnst added in the raw materials for preparing the mild wound disinfectant and the comprehensive performance of the finally obtained wound disinfectant are better.

In a preferred embodiment, the mild wound disinfectant is prepared from raw materials including, by weight, 38 portions of sanguisorba officinalis, 31 portions of phellodendron amurense, 24 portions of herba lycopi, 27 portions of safflower, 23 portions of rhubarb, 20 portions of sappan wood, 35 portions of dalbergia wood, 24 portions of dandelion, 25 portions of purslane, 25 portions of hawthorn, 26 portions of honeysuckle, 26 portions of angelica dahurica, 24 portions of angelica, 25 portions of radix scutellariae, and 24 portions of arnebia euchroma.

(4) drying and crushing safflower and angelica with required weight, adding distilled water, heating and refluxing, filtering, concentrating the filtrate to obtain D, and drying the filter residue to obtain extract powder; drying and crushing cortex phellodendri, adding the extracted powder, 1-3 wt% of an auxiliary agent and 80wt% of an ethanol aqueous solution, heating, refluxing, filtering, and concentrating the filtrate to obtain E;

The applicant finds that the sappan wood, the garden burnet root, the honeysuckle flower and the eupatorium japonicum can mutually promote the dissolution and extraction of the effective components in the components when being extracted together. Furthermore, it has been unexpectedly found that antiallergic effects can also be achieved to some extent.

In a preferred embodiment, arnebia euchroma (Royle) Johnst is also added during the extraction of the radix scutellariae and the rheum officinale in the step (2).

The inventor unexpectedly discovers that when the residual part of arnebia euchroma (Royle) Johnst which is extracted by water is mixed with radix scutellariae and rhubarb and then extracted by 75wt% of ethanol water solution, the extraction efficiency is higher, and the antibacterial efficiency, the wound healing performance and other effects of the finally obtained disinfectant are obviously improved. Microwave extraction is adopted, and the microwave power is set to be 500-700, so that the best extraction effect is found. The microwave in the invention is an electromagnetic wave and consists of two parts of energy, namely an electric field and a magnetic field. In the invention, high-frequency electromagnetic waves in microwaves penetrate through raw materials such as radix scutellariae, rheum officinale and the like in an ethanol water solution and enter vascular bundles and glandular systems in the raw materials to break cells, and active ingredients in the cells freely flow out. The electromagnetic field generated by the microwave can also accelerate the diffusion of the components in the raw materials to the solvent interface, so that the effective components are dissolved out at a higher speed at a relatively lower temperature, and the extraction quality is ensured to the maximum extent. The microwave extraction has the advantages of high selectivity, short operation time, high effective component yield and the like.

The inventor unexpectedly discovers that the performances of the wound disinfectant prepared finally when the radix scutellariae, the rheum officinale and the arnebia euchroma are extracted together are obviously improved, such as bacteriostatic effect and the like. The possible reasons are that the three components can promote the dissolution of anthraquinone derivatives such as emodin, rhein, aloe-emodin and the like in rhubarb under the action of microwaves in 75wt% ethanol water solution, and the effective substances can inhibit the synthesis of nucleic acid and protein of bacterial cells and the glycometabolism, block the respiratory chain of bacteria, cut off the energy source required by the growth of the bacteria and improve the antibacterial performance of the wound disinfectant.

According to the invention, ultrasonic extraction of the hawthorn and the masson grass together in a 60wt% ethanol aqueous solution is found, and the effect is good and is stronger than that of a disinfectant liquid obtained after single extraction. The ultrasonic cavitation treatment is carried out on the system, under the mutual promotion of hawthorn and dens equi, the cell wall can be broken, thereby being beneficial to the leaching of the content, the diffusion of the solvent into the cell and the dissolution of the effective components are increased, the extraction time is greatly shortened, the extraction efficiency is improved, and the damage effect on the extracted substances is not generated. And when the dispersing agent such as polyethylene glycol is added in the extraction process, the extraction time can be shortened, and the dissolution and diffusion of some components which are easy to agglomerate and difficult to dissolve are facilitated.

The ultrasonic extraction in the invention is to extract the raw material by using ultrasonic waves. The ultrasonic wave is elastic mechanical vibration which generates strong vibration, high speed, strong cavitation effect and stirring effect, so that the disturbance effect, the cavitation effect and the heat effect generated by ultrasonic wave radiation pressure intensity in ultrasonic wave extraction cause mechanical stirring, cells in hawthorn and malted forage raw materials are damaged, and the extraction effect of effective components in the raw materials is improved. The dispersant is added in the ultrasonic extraction process, so that the effective components in the system can be fully extracted, and the extraction time is shortened.

In a preferred embodiment, the dispersant in step (3) is selected from one or more of polyethylene glycol, gelatin, and cellulose derivatives.

The inventor finds that the dissolution of effective substances can be promoted and the extraction effect can be improved by adding 1-3 wt% of an auxiliary agent in the total powder mass in the extraction process of the phellodendron, the safflower and the angelica. The possible reasons are that a large amount of mucus cells are contained in phellodendron, the swelling of other tissue cells and the dissolution and diffusion of active ingredients in tissues are hindered by water absorption and expansion in the extraction process, and the addition of the auxiliary agent can destroy the cell structure to fully dissolve active substances in cells.

In a preferred embodiment, the auxiliary agent in step (4) is one or more selected from anhydrous sodium sulfate, anhydrous magnesium sulfate and sodium chloride.

According to the invention, the dahurian angelica root is distilled and extracted to obtain effective water-soluble components such as palmitic acid, stigmasterol, beta-sitosterol, beta-carotene and the like, and the rest components, dandelion and rosewood are extracted by ethyl acetate together to improve the dissolution rate of coumarin compounds such as bergapten, peucedanum root bone ester, phellopterin, 8-methoxy-4-oxy- (3-methyl-2-butenyl) psoralen, phellandrene alcohol and the like in the dahurian angelica root, and volatile oil such as formal diol, daucosterol, alkaloid and the like, so that the wound disinfectant can break the persistent blood, supplement new blood, expel pus and promote granulation, activate blood and relieve pain, and improve various performances of the disinfectant. In addition, the dandelion, the dalbergia wood and the angelica dahurica can promote the dissolution of effective components such as furano coumarins, xanthotoxin, peucedanum lactone, hydrated oxidized decursin, dandelion saponins, flavonoids, inositol and the like, and the components can enhance the lipolysis induced by epinephrine and ACTH, inhibit the effect of converting glucose into fat induced by insulin, and indirectly promote lipolysis and inhibit fat synthesis. Can also promote the secretion of insulin in vivo to a certain extent, resist hyperglycemia, even can disinfect wounds caused by diabetes and the like, and improve the comprehensive performance of the wound disinfection solution. The applicant finds that the finally prepared disinfectant after the three components are extracted together has the characteristic of antianaphylaxis to a certain degree.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

Examples

Example 1

Embodiment 1 provides a mild wound disinfectant, which is prepared from 15 parts by weight of sanguisorba officinalis, 20 parts by weight of phellodendron amurense, 17 parts by weight of herba lycopi, 22 parts by weight of safflower, 20 parts by weight of rheum officinale, 15 parts by weight of sappan wood, 18 parts by weight of rosewood heart wood, 18 parts by weight of dandelion, 20 parts by weight of purslane, 20 parts by weight of hawthorn, 20 parts by weight of honeysuckle, 20 parts by weight of angelica dahurica, 18 parts by weight of angelica sinensis and 18.

The preparation method of the mild wound disinfection solution comprises the following steps:

(1) oven drying lignum sappan, radix Sangusorbae, flos Lonicerae and herba Lycopi, pulverizing, adding 50wt% ethanol water solution 12 times of the total powder, heating and refluxing for 2 hr, filtering, and concentrating the filtrate to obtain viscous substance A;

(2) taking radix Scutellariae and radix Et rhizoma Rhei, oven drying, pulverizing, adding 75wt% ethanol water solution 15 times of the total weight of the raw materials, stirring, extracting with 650w microwave for 30min, filtering, and concentrating the filtrate to obtain B;

(3) drying and crushing the hawthorn and the masson grass in required weight, adding a 25-time weight of 60wt% ethanol aqueous solution and 0.5 wt% polyethylene glycol (weight average molecular weight is 400), stirring and mixing, then performing ultrasonic extraction for 45min under 250w of power, filtering, and concentrating the filtrate to obtain E;

(4) drying and crushing safflower and angelica sinensis with required weight, adding distilled water, heating and refluxing, filtering, concentrating the filtrate to obtain D, and drying the filter residue to obtain extract powder; drying and crushing cortex phellodendri, adding the extracted powder, 1 wt% of anhydrous magnesium sulfate and 80wt% of ethanol aqueous solution, heating, refluxing, filtering, and concentrating the filtrate to obtain E;

(5) drying and crushing the angelica dahurica with the required weight, adding distilled water with the weight 5 times that of the powder, heating and refluxing for 2 hours, filtering, and concentrating the filtrate to obtain F; drying the filter residue, adding the dandelion, the dalbergia wood and 60wt% ethanol which is 8 times of the angelica dahurica by weight into the dried powder, heating and refluxing for 1.5 hours, centrifuging, precipitating and filtering, and concentrating the filtrate to obtain G;

Example 2

Embodiment 2 provides a mild wound disinfectant, which is prepared from raw materials including, by weight, 50 parts of sanguisorba officinalis, 45 parts of phellodendron amurense, 33 parts of herba lycopi, 35 parts of safflower, 30 parts of rheum officinale, 27 parts of sappan wood, 45 parts of dalbergia wood, 30 parts of dandelion, 32 parts of purslane, 33 parts of hawthorn, 35 parts of honeysuckle, 38 parts of radix angelicae, 30 parts of angelica sinensis and 35 parts of radix scutellariae.

(3) drying and pulverizing fructus crataegi and herba Portulacae of required weight, adding 25 times of 60wt% ethanol water solution and 2.5wt% gelatin (CAS No. 9000708, available from Chinese medicinal materials), stirring, mixing, performing ultrasonic extraction at 250w power for 45min, filtering, and concentrating the filtrate to obtain E;

(4) drying and crushing safflower and angelica sinensis with required weight, adding distilled water, heating and refluxing, filtering, concentrating the filtrate to obtain D, and drying the filter residue to obtain extract powder; drying and crushing cortex phellodendri, adding the extracted powder, 3wt% of sodium chloride and 80wt% of ethanol aqueous solution, heating, refluxing, filtering, and concentrating the filtrate to obtain E;

Example 3

Embodiment 3 provides a mild wound disinfectant, which is prepared from raw materials including, by weight, 24 parts of sanguisorba officinalis, 28 parts of phellodendron amurense, 20 parts of herba lycopi, 28 parts of safflower, 20 parts of rheum officinale, 16 parts of sappan wood, 26 parts of dalbergia wood, 20 parts of dandelion, 23 parts of purslane, 22 parts of hawthorn, 22 parts of honeysuckle, 23 parts of angelica dahurica, 20 parts of angelica sinensis and 20 parts of radix scutellariae.

(3) drying and crushing the hawthorn and the masson grass in required weight, adding a 25-time weight of 60wt% ethanol aqueous solution and 1.5 wt% polyethylene glycol (weight average molecular weight is 400), stirring and mixing, then performing ultrasonic extraction for 45min under 250w of power, filtering, and concentrating the filtrate to obtain E;

(4) drying and crushing safflower and angelica sinensis with required weight, adding distilled water, heating and refluxing, filtering, concentrating the filtrate to obtain D, and drying the filter residue to obtain extract powder; drying and crushing cortex phellodendri, adding the extracted powder, 1.8 wt% of anhydrous sodium sulfate and 80wt% of ethanol water solution, heating, refluxing, filtering, and concentrating the filtrate to obtain E;

Example 4

Embodiment 4 provides a mild wound disinfectant, which is prepared from raw materials including, by weight, garden burnet 45, phellodendron bark 32, lycopus herb 26, safflower 32, rhubarb 26, sappan wood 22, rosewood 38, dandelion 26, purslane 27, hawthorn 27, honeysuckle 28, angelica dahurica 29, angelica sinensis 27 and scutellaria 28.

Example 5

Embodiment 5 provides a mild wound disinfectant, which is prepared from raw materials including, by weight, 38 parts of sanguisorba officinalis, 31 parts of phellodendron, 24 parts of herba lycopi, 27 parts of safflower, 23 parts of rheum officinale, 20 parts of sappan wood, 35 parts of dalbergia wood, 24 parts of dandelion, 25 parts of purslane, 25 parts of hawthorn, 26 parts of honeysuckle, 26 parts of radix angelicae, 24 parts of angelica sinensis and 25 parts of radix scutellariae.

Example 6

Embodiment 6 provides a mild wound disinfectant, which is prepared from raw materials including, by weight, 38 parts of sanguisorba officinalis, 31 parts of phellodendron, 24 parts of herba lycopi, 27 parts of safflower, 23 parts of rheum officinale, 20 parts of sappan wood, 35 parts of rosewood, 24 parts of dandelion, 25 parts of purslane, 25 parts of hawthorn, 26 parts of honeysuckle, 26 parts of radix angelicae, 24 parts of angelica sinensis, 25 parts of radix scutellariae and 24 parts of sinkiang arnebia root.

(2) taking radix Scutellariae, radix et rhizoma Rhei and Sinkiang radix Arnebiae, oven drying, pulverizing, adding 75wt% ethanol water solution 15 times of the total raw material powder, stirring, mixing, extracting with 650w microwave for 30min, filtering, and concentrating the filtrate to obtain B;

Comparative example 1

Comparative example 1 provides a mild wound disinfectant, and raw materials for preparing the mild wound disinfectant comprise, by weight, 31 parts of phellodendron, 24 parts of herba lycopi, 27 parts of safflower, 23 parts of rheum officinale, 20 parts of sappan wood, 24 parts of dandelion, 25 parts of purslane, 25 parts of hawthorn, 26 parts of honeysuckle, 26 parts of radix angelicae, 24 parts of angelica sinensis and 25 parts of radix scutellariae.

(1) oven drying lignum sappan, flos Lonicerae and herba Lycopi, pulverizing, adding 50wt% ethanol water solution 12 times of the total powder, heating and refluxing for 2 hr, filtering, and concentrating the filtrate to obtain viscous substance A;

(2) taking radix Scutellariae and radix et rhizoma Rhei of required weight, oven drying, pulverizing, adding 75wt% ethanol water solution 15 times of the total raw material powder weight, stirring, mixing, extracting with 650w microwave for 30min, filtering, and concentrating the filtrate to obtain B;

(5) drying and crushing the angelica dahurica with the required weight, adding distilled water with the weight 5 times that of the powder, heating and refluxing for 2 hours, filtering, and concentrating the filtrate to obtain F; drying the filter residue, adding 60wt% ethanol 8 times of the weight of dandelion and angelica dahurica into the dried powder, heating and refluxing for 1.5 hours, centrifuging, precipitating and filtering, and concentrating the filtrate to obtain G;

Comparative example 2

Comparative example 2 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfection solution is different from that in the embodiment 6 in that the sappan wood, the garden burnet root, the honeysuckle and the herba lycopi in the step (1) are separately extracted according to the method in the step (1), and the obtained filtrate is blended to form the dope A.

Comparative example 3

Comparative example 3 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfection solution is different from that in the embodiment 6 in that the sappan wood, the honeysuckle and the herba lycopi in the step (1) are extracted according to the method in the step (1), and the obtained filtrate and the filtrate obtained by separately extracting the garden burnet root according to the method in the step (1) are blended to form the dope A.

Comparative example 4

Comparative example 4 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that of example 6 in that the scutellaria baicalensis, the rheum officinale and the arnebia euchroma (Royle) Johnst in the step (2) are extracted separately and then filtrate is blended to obtain the B.

Comparative example 5

Comparative example 5 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that in the embodiment 6 in that the hawthorn and the masson grass in the step (3) are separately extracted according to the method in the step (3), and the obtained filtrates are combined and concentrated to obtain E.

Comparative example 6

Comparative example 6 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that of the mild wound disinfectant in example 6 in that no dispersant is added in the step (3).

Comparative example 7

Comparative example 7 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that of the example 6 in that the phellodendron amurense in the step (4) is extracted separately according to the method, namely, the residual components after the water extraction of the safflower and the angelica are not added in the step E.

Comparative example 8

Comparative example 8 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that of the mild wound disinfectant in the embodiment 6, wherein the safflower and the angelica are not subjected to water extraction in the step (4), namely, the D component is not contained in the final wound disinfectant; extracting Carthami flos, radix Angelicae sinensis and cortex Phellodendri with ethanol according to the method (4).

Comparative example 9

Comparative example 9 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfection solution is different from that of the mild wound disinfection solution in the embodiment 6, in the step (5), the dandelion, the dalbergia wood and the angelica dahurica water extraction residues are independently subjected to ethanol extraction according to the method, and the obtained extracts are blended and concentrated to obtain G.

Comparative example 10

Comparative example 10 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that of the mild wound disinfectant in the embodiment 6, in the step (5), the dandelion and the rosewood heart wood are subjected to ethanol extraction according to the method, the obtained extract and the angelica dahurica are extracted separately according to the method, and the two obtained extracts are blended and concentrated to obtain G.

Comparative example 11

Comparative example 11 provides a mild wound disinfectant prepared from the same raw materials as in example 6.

The preparation method of the mild wound disinfectant is different from that of the comparative example 2 in that the dandelion, the dalbergia wood and the radix angelicae water extraction residues in the step (5) are independently subjected to ethanol extraction according to the method, and the obtained extracts are blended and concentrated to obtain G.

Evaluation of Performance

1. Test of bacteriostatic Property

Respectively inoculating slant cultures of staphylococcus aureus, escherichia coli, candida albicans and pseudomonas aeruginosa into a meat soup culture medium in a circle, respectively inoculating 0.2 ml of slant cultures into 3 plate culture media after culturing for 24 hours at 37 ℃, and respectively dripping equal amounts of the mild wound disinfection solution prepared in the above embodiment and the comparative example into 3 plate culture media; after 3min of action, the average sterilization rate is detected, and the other operations all meet the disinfection technical Specification.

2. Allergy test

The mild wound disinfectant prepared by the methods of the above examples and comparative examples is prepared into disinfectant with the same concentration and is subjected to aseptic treatment. And then, randomly selecting 32 experimental rats, injecting the prepared disinfectant into the same position of the ears of the old rats with the same dosage, and observing whether the rats injected with the disinfectant have the allergic characteristics of red swelling, pruritus and the like within 45 min. The degree of allergy is recorded on four scales of overt allergy (meaning that the allergic characteristics are clear), allergy (meaning that some allergic characteristics are present), mild (meaning that the characteristics are mild allergic but the phenomenon is not clear), and no allergy (no allergic characteristics are present).

TABLE 1 Performance test Table

From the above table 1, it can be seen that the mild wound disinfectant provided by the invention has good bacteriostatic and bactericidal effects on bacteria which are easy to infect wounds, such as staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa and the like, and can avoid infection of wounds. Moreover, the raw materials for preparing the mild wound disinfectant are all natural plants, and the allergy of the obtained wound disinfectant to the wound can be avoided by extracting the mild wound disinfectant through the specific combination and method among the specific plant raw materials.

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. A mild wound disinfectant is characterized in that the mild wound disinfectant is prepared from, by weight, 15-50 parts of sanguisorba officinalis, 20-45 parts of golden cypress, 17-33 parts of herba lycopi, 22-35 parts of safflower, 20-30 parts of rheum officinale, 15-27 parts of sappan wood, 18-45 parts of dalbergia wood, 18-30 parts of dandelion, 20-32 parts of purslane, 20-33 parts of hawthorn, 20-35 parts of honeysuckle, 20-38 parts of radix angelicae, 18-30 parts of angelica sinensis and 18-35 parts of scutellaria baicalensis;

the preparation method of the mild wound disinfection solution at least comprises the following steps:

(2) taking the required weight of scutellaria baicalensis and the required weight of rhubarb, drying and crushing, then adding 75wt% of ethanol water solution, stirring, mixing, performing microwave extraction, filtering, and concentrating the filtrate to obtain B;

(3) drying and crushing the hawthorn and the purslane with required weight, adding 60wt% of ethanol water solution and 0.5-2.5 wt% of dispersant, stirring and mixing, then performing ultrasonic extraction at the power of 250w, filtering, and concentrating the filtrate to obtain C;

(6) blending the A, B, C, D, E, F and G obtained in the steps (1) to (5), adding medical alcohol and distilled water for dilution, and performing aseptic treatment to obtain the mild wound disinfectant;

the dispersing agent in the step (3) is selected from one or more of polyethylene glycol, gelatin and cellulose derivatives;

in the step (4), the auxiliary agent is selected from one or more of anhydrous sodium sulfate, anhydrous magnesium sulfate and sodium chloride.

2. The mild wound disinfectant as claimed in claim 1, wherein the mild wound disinfectant is prepared from, by weight, 24-45 parts of sanguisorba officinalis, 28-32 parts of phellodendron amurense, 20-26 parts of herba lycopi, 28-32 parts of safflower, 20-26 parts of rheum officinale, 16-22 parts of sappan wood, 26-38 parts of dalbergia wood, 20-26 parts of dandelion, 23-27 parts of purslane, 22-27 parts of hawthorn, 22-28 parts of honeysuckle, 23-29 parts of radix angelicae, 20-27 parts of angelica sinensis and 20-28 parts of scutellaria baicalensis.

3. The mild wound disinfectant is characterized by comprising, by weight, 15-50 parts of sanguisorba officinalis, 20-45 parts of golden cypress, 17-33 parts of herba lycopi, 22-35 parts of safflower carthamus, 20-30 parts of rheum officinale, 15-27 parts of sappan wood, 18-45 parts of lignum dalbergiae odoriferae, 18-30 parts of dandelion, 20-32 parts of purslane, 20-33 parts of hawthorn, 20-35 parts of honeysuckle, 20-38 parts of radix angelicae, 18-30 parts of angelica sinensis, 18-35 parts of scutellaria baicalensis and 20-26 parts of sinkiang arnebia root.

4. The mild wound disinfection solution of claim 3, wherein the mild wound disinfection solution is prepared from the raw materials of, by weight, 38 parts of sanguisorba officinalis, 31 parts of phellodendron amurense, 24 parts of herba lycopi, 27 parts of safflower, 23 parts of rheum officinale, 20 parts of sappan wood, 35 parts of dalbergia wood, 24 parts of dandelion, 25 parts of purslane, 25 parts of hawthorn, 26 parts of honeysuckle, 26 parts of angelica dahurica, 24 parts of angelica sinensis, 25 parts of scutellaria baicalensis and 24 parts of sinkiang arnebia root.

5. The method of claim 3, wherein the method comprises at least the following steps:

the auxiliary agent in the step (4) is selected from one or more of anhydrous sodium sulfate, anhydrous magnesium sulfate and sodium chloride;

sinkiang arnebia root is also added in the process of extracting the scutellaria and the rhubarb in the step (2).

6. The use of a mild wound disinfectant prepared by the process of claim 1, wherein the mild wound disinfectant is used for disinfecting wounds caused by abrasion, laceration, cut, puncture, burn, diabetes.