CN105902595A - Sea buckthron oil-containing medicine for treating scalds, and preparation method of medicine - Google Patents

Sea buckthron oil-containing medicine for treating scalds, and preparation method of medicine Download PDF

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CN105902595A
CN105902595A CN201610317482.2A CN201610317482A CN105902595A CN 105902595 A CN105902595 A CN 105902595A CN 201610317482 A CN201610317482 A CN 201610317482A CN 105902595 A CN105902595 A CN 105902595A
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medicament
hippophae
oleum hippophae
weight
treating scald
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王欢
安月玲
王锦凤
米世文
于雪
龚晨
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QINGHAI QINGHUA BOZHONG BIOTECHNOLOGY CO Ltd
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QINGHAI QINGHUA BOZHONG BIOTECHNOLOGY CO Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The invention provides a sea buckthron oil-containing medicine for treating scalds, and a preparation method of the medicine. The sea buckthron oil-containing medicine for treating scalds is prepared from the following components in parts by weight: 50-80 parts of sea buckthorn seed oil, 10-25 parts of radix lithospermi and 2-5 parts of borneol. The sea buckthron oil-containing medicine for treating scalds solves the problems that the existing medicine for treating burns and scalds is long in curative time and poor in treatment effect, shallow scars are left in the skin, and the like. The sea buckthron oil-containing medicine for treating scalds has the advantages of being rapid in effect, can obviously relieve the pain of patients, enables no scar to be left in the skin, and the like. According to the preparation method of the sea buckthron oil-containing medicine for treating scalds, the sea buckthron oil-containing medicine for treating scalds is obtained by mixing all the raw materials and homogenizing. The preparation method has the advantages of being simple, convenient, easy to operate, and the like, thus being suitable for being widely used.

Description

A kind of Oleum Hippophae medicament for treating scald and preparation method thereof
Technical field
The present invention relates to scald medicine for external use field, in particular to a kind of Oleum Hippophae medicament for treating scald and Preparation method.
Background technology
Burn and scald is the burnings such as unexpected injury common in life, flame, boiling water, deep fat, vapours The burn and scald that thing or scorching hot thing cause is recurrent thing.Different according to burn and scald degree, burn and scald Wound can be divided into four classes: I degree burn and scald, damages epidermis shallow-layer, including cutin, clear layer, granular layer, Sometimes can injure prickle cell layer, but stratum germinativum is still living and in good health, regeneration capacity is enlivened;Shallow II degree is burnt, damage Epidermis deep layer and papillary layer of corium, rely on germinal layer cell and the appendages of skin of remaining, can enter quickly Row is repaired;Deep II degree burn and scald, injures corium, up to deep layer.The appendages of skin relying on residual are formed Epithelial island and gradually epithelization;III degree burn and scald, injures full thickness skin, even reaches subcutaneous fat, flesh Meat, skeleton, have cicatrix the most afterwards and leave over.Its treatment time of existing burn-scald medicine is long, uses process In can not substantially reduce the pain of patient, cicatrix can be left after wound healing.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of Oleum Hippophae medicament for treating scald, to solve existing burn-scald medicine Healing time is long, and therapeutic effect is poor, and skin can leave the problems such as plain cicatrix.Described Oleum Hippophae Medicament for treating scald, has instant effect, can substantially alleviate the advantages such as patient pain's sense, preventing from scar.
The second object of the present invention is to provide the preparation method of a kind of described Oleum Hippophae medicament for treating scald, should Each raw material mixes by method, be homogenized after obtain this Oleum Hippophae medicament for treating scald, have simple, convenient, be prone to The advantages such as operation, are suitable for being widely used.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of Oleum Hippophae medicament for treating scald, the following component including preparing according to parts by weight:
Fructrs Hippophae seed oil 50-80 part, Radix Arnebiae (Radix Lithospermi) 10-25 part, Borneolum Syntheticum 2-5 part.
Fructus Hippophae, has another name called vinegar willow, black thorn, acid thorn etc., originates from Qinghai-Tibet Platean, for Elaeangnaceae Fructus Hippophae Belong to machaka, have eliminate the phlegm, profit lung, removing dampness, strong cloudy, the effect of yang invigorating.It addition, Fructus Hippophae is also There is the function of strengthening the spleen and nourishing the stomach and removing blood stasis with potent drugs hemostasis.The Fructrs Hippophae seed oil extracted from seed of Fructus Hippophae is pale brown Color, to brownish red transparent oily liquid, includes flavone, alkaloid, sterols, triterpene alkenes and multiple Vitamin etc. more than 140 plant sea-buckthorn biological active component.
Radix Arnebiae (Radix Lithospermi), another name mountain Radix Arnebiae (Radix Lithospermi), Zi Dan, purple cottonrose hibiscus, blood, Radix Arnebiae (Radix Lithospermi) etc., be Boraginaceae Lithospermum Plant, perennial herb, it has effect of removing heat from blood, activating blood and clearing heat, removing toxic substances.
Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae etc., is by Compositae Herba Blumeae Balsamiferae stem and leaf or canella dragon Brain Camphor tree branch and leaf obtain through steam distillation recrystallization.Borneolum Syntheticum acrid in the mouth, hardship, be slightly cold;GUIXIN, liver, Lung meridian;Delicate fragrance a surname dissipate, and has refreshment of having one's ideas straightened out, the scattered poison of heat clearing away, effect of improving acuity of vision and removing nebula, can treat Excess syndrome of stroke coma, conjunctival congestion and swelling pain, sore throat aphtha, swell and ache for skin infection, burst after the symptom such as do not hold back.
Radix Arnebiae (Radix Lithospermi) has inhibitory action in capital section 68-1 virus test tube, to staphylococcus aureus, Bacterium prodigiosum, Pyogenic baeceria, escherichia coli also have inhibitory action, and can accelerate epithelial growth, arrange in pairs or groups with Oleum Hippophae.Add After entering Radix Arnebiae (Radix Lithospermi) and the Borneolum Syntheticum of special ratios, the therapeutic efficiency of Oleum Hippophae can be accelerated, alleviate rapidly the wounded's pain Bitterly, accelerating wound healing, it is to avoid affected part scar.
Preferably, in terms of parts by weight, also include: Aloe 10-20 part.
Aloe has sterilization, antiinflammatory and moistening beautification function, can effectively Lavender Extract, reducing swelling and alleviating pain, Treatment cicatrix.
Preferably, in terms of parts by weight, also include: Flos Lonicerae 5-10 part.
The Main Function of Flos Lonicerae is the effect having heat-clearing and toxic substances removing to affected part, and he also has antiinflammatory, benefit simultaneously Empty effect treating wind, can be prevented effectively from wound infection.
Preferably, in terms of parts by weight, also include: Radix Et Rhizoma Rhei 2-10 part.
Radix Et Rhizoma Rhei has attacks the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.Start with, Foot yangming Channel, therefore the heat-clearing and toxic substances removing for the burn and scald of trick has special efficacy, contributes to blood stasis dispelling and dissipates Knot, it is to avoid scar.
Aloe, Flos Lonicerae and Radix Et Rhizoma Rhei collocation use, and can more effectively treat burn and scald with heat-clearing and toxic substances removing, Avoid the generation of cicatrix.
Preferably, in terms of parts by weight, also include: Rhizoma Paridis 4-8 part.
Rhizoma Paridis, for liliaceous plant Rhizoma Paridis or the dry rhizome of Rhizoma Paridis.Its bitter in the mouth, property It is slightly cold;Slightly poisonous.There is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, effect of cool liver arresting convulsion.
Preferably, also include: Radix Angelicae Sinensis 3-7 part.
Radix Angelicae Sinensis, for the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen Warp.There is the effect of replenishing and activating blood, menstruction regulating and pain relieving.
The preparation method of a kind of Oleum Hippophae medicament for treating scald, comprises the following steps:
By other raw materials in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum and in powder according to set weight After number mixing, it is the seed of Fructus Hippophae of 75-85 DEG C that the material of mixing adds extremely set parts by weight and temperature In oil, after sizing mixing and being homogenized and get final product.
By the raw material stoving in addition to Fructrs Hippophae seed oil, remove unnecessary moisture, retain effective one-tenth of Chinese medicine Point, it is to avoid unnecessary moisture affects the efficacy of a drug of medicament for treating scald.Wherein, the temperature of Fructrs Hippophae seed oil is 75-85 DEG C, Can avoid grease mixing difficulty, and should at a temperature of can sufficiently dissolve the effective one-tenth in Chinese medicine Point, improve drug effect.
Preferably, the preparation method of described Oleum Hippophae medicament for treating scald, specifically include following steps:
Raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried to constant weight at 80-100 DEG C, according to Set parts by weight mix, pulverize, cross 80-140 mesh sieve, obtain pulverizing fines;Material by mixing Add to set parts by weight and Fructrs Hippophae seed oil that temperature is 75-85 DEG C, after sizing mixing and being homogenized I.e. obtain this Oleum Hippophae medicament for treating scald.The temperature dried is selected in 80-100 DEG C, both can be efficiently and quickly Dry the moisture in Chinese medicine, it is also possible to avoid high temperature to the infringement of effective ingredient in Chinese medicine.
80-140 mesh sieves, convenient processing and effective rapid dissolution of Chinese medicine material.
Preferably, described Oleum Hippophae uses the method for supercritical carbon dioxide extraction to prepare, and described sand The mass fraction of spine oil is 50-80%.
The principle of supercritical carbon dioxide extraction separation process is to utilize supercritical carbon dioxide special to some Different natural product has special dissolution, utilizes solvability and its density of supercritical carbon dioxide Relation, i.e. utilize pressure and temperature that the impact of supercritical carbon dioxide solvability is carried out. In the supercritical state, supercritical carbon dioxide is contacted with material to be separated so that it is selective Ground extracts polarity size, the boiling point height composition the most different with molecular size range successively.Using should Oleum Hippophae purity prepared by method is high, and treatment is scalded effective.Oleum Hippophae mass fraction ensures at 50-80% Between, it is to avoid concentration is too low, reduces the drug effect of medicament for treating scald.
Preferably, described homogenate uses high-speed homogenization machine to carry out, and the rotating speed of homogenate is 7000-9000 Rev/min, the time of homogenate is 3-10 minute.
Homogenate can ensure that and sufficiently mixes between Oleum Hippophae and Chinese medicine, is conducive to playing in Chinese medicine effective Effect of composition.
Compared with prior art, the invention have the benefit that
1), the present invention a kind of Oleum Hippophae medicament for treating scald is provided, instant effect, can substantially alleviate patient pain Sense, preventing from scar.
2), the second object of the present invention be to provide the preparation method of a kind of described Oleum Hippophae medicament for treating scald, Each raw material mixes by the method, be homogenized after obtain this Oleum Hippophae medicament for treating scald, have simple, convenient, easily In advantages such as operations, it is suitable for being widely used.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but this area skill Art personnel are it will be appreciated that the following example is merely to illustrate the present invention, and are not construed as limiting the present invention Scope.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer Carry out.Agents useful for same or instrument unreceipted production firm person, being can be by commercially available purchase acquisition Conventional products.
Embodiment 1
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 50 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Borneolum Syntheticum 2 grams.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
By other raw materials in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum and in powder according to shown in above-mentioned After quality mixing, the material of mixing is added to set weight and Fructrs Hippophae seed oil that temperature is 75 DEG C, This Oleum Hippophae medicament for treating scald is i.e. obtained after sizing mixing and being homogenized.
Embodiment 2
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 50 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, Borneolum Syntheticum 2 grams, Aloe 10 grams.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
Raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried to constant weight at 80 DEG C, according to above-mentioned institute The mass mixing that shows, pulverize, cross 80 mesh sieves, obtain pulverizing fines;Then Fructrs Hippophae seed oil is heated to 75 DEG C, add in above-mentioned pulverizing fines, obtain pastel;Put into pastel in high-speed homogenization machine Row homogenate, the rotating speed of homogenate is 7000 revs/min, and the time of homogenate is 3 minutes, obtains this Oleum Hippophae Medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 50%.
Embodiment 3
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 60 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Borneolum Syntheticum 3 grams, Aloe 20 grams, Flos Lonicerae 5 grams.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
After raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried 15 minutes at 100 DEG C, according to upper State shown mass mixing, pulverize, cross 140 mesh sieves, obtain pulverizing fines;Then by Fructrs Hippophae seed oil It is heated to 85 DEG C, adds in above-mentioned pulverizing fines, obtain pastel;Pastel is put into high-speed homogenization Being homogenized in machine, the rotating speed of homogenate is 9000 revs/min, and the time of homogenate is 10 minutes, is somebody's turn to do Oleum Hippophae medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 80%.
Embodiment 4
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 70 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Borneolum Syntheticum 4 grams, Aloe 15 grams, Flos Lonicerae 10 grams, Radix Et Rhizoma Rhei 2 grams.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
After raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried 11 minutes at 90 DEG C, according to above-mentioned Shown mass mixing, pulverize, cross 100 mesh sieves, obtain pulverizing fines;Then Fructrs Hippophae seed oil is added Heat, to 80 DEG C, adds in above-mentioned pulverizing fines, obtains pastel;Pastel is put into high-speed homogenization machine In be homogenized, the rotating speed of homogenate is 8000 revs/min, and the time of homogenate is 3-10 minute, is somebody's turn to do Oleum Hippophae medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 60%.
Embodiment 5
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 75 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, Borneolum Syntheticum 3 grams, Aloe 18 grams, Flos Lonicerae 6 grams, Radix Et Rhizoma Rhei 10 grams, Rhizoma Paridis 4 grams.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
After raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried 13 minutes at 85 DEG C, according to above-mentioned Shown mass mixing, pulverize, cross 120 mesh sieves, obtain pulverizing fines;Then Fructrs Hippophae seed oil is added Heat, to 75 DEG C, adds in above-mentioned pulverizing fines, obtains pastel;Pastel is put into high-speed homogenization machine In be homogenized, the rotating speed of homogenate is 7000 revs/min, and the time of homogenate is 6 minutes, obtains this sand Spine oil medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 70%.
Embodiment 6
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 55 grams, Radix Arnebiae (Radix Lithospermi) 17 grams, Borneolum Syntheticum 3 grams, Aloe 15 grams, Flos Lonicerae 7 grams, Radix Et Rhizoma Rhei 3 grams, Rhizoma Paridis 4 grams, Radix Angelicae Sinensis 3 parts.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
After raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried 14 minutes at 100 DEG C, according to upper State shown mass mixing, pulverize, cross 100 mesh sieves, obtain pulverizing fines;Then by Fructrs Hippophae seed oil It is heated to 80 DEG C, adds in above-mentioned pulverizing fines, obtain pastel;Pastel is put into high-speed homogenization Being homogenized in machine, the rotating speed of homogenate is 9000 revs/min, and the time of homogenate is 8 minutes, is somebody's turn to do Oleum Hippophae medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 55%.
Embodiment 7
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 50 grams, Radix Arnebiae (Radix Lithospermi) 12 grams, Borneolum Syntheticum 3 grams, Aloe 15 grams, Flos Lonicerae 6 grams, Radix Et Rhizoma Rhei 4 grams, Rhizoma Paridis 5 grams, Radix Angelicae Sinensis 5 parts.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
After raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried 10 minutes at 100 DEG C, according to upper State shown mass mixing, pulverize, cross 120 mesh sieves, obtain pulverizing fines;Then by Fructrs Hippophae seed oil It is heated to 85 DEG C, adds in above-mentioned pulverizing fines, obtain pastel;Pastel is put into high-speed homogenization Being homogenized in machine, the rotating speed of homogenate is 9000 revs/min, and the time of homogenate is 7 minutes, is somebody's turn to do Oleum Hippophae medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 80%.
Embodiment 8
The Oleum Hippophae medicament for treating scald that the present embodiment provides, including following component:
Fructrs Hippophae seed oil 70 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, Borneolum Syntheticum 4 grams, Aloe 15 grams, Flos Lonicerae 10 grams, Radix Et Rhizoma Rhei 2 grams, Rhizoma Paridis 6 grams, Radix Angelicae Sinensis 5 parts.
The preparation method of this Oleum Hippophae medicament for treating scald, specifically includes following steps:
After raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried 10-15 minute at 80-100 DEG C, According to the mass mixing shown in above-mentioned, pulverize, cross 80-140 mesh sieve, obtain pulverizing fines;Then will Fructrs Hippophae seed oil is heated to 75-85 DEG C, adds in above-mentioned pulverizing fines, obtains pastel;Pastel is put Entering in high-speed homogenization machine and be homogenized, the rotating speed of homogenate is 7000-9000 rev/min, and the time of homogenate is 3-10 minute, obtain this Oleum Hippophae medicament for treating scald;
Wherein, Oleum Hippophae uses the method for carbon dioxide supercritical fluid extraction to prepare, and the quality of Oleum Hippophae Mark is 80%.
Experimental example 1 scalds patient's average curative day statistics
Certain is scalded section hospital and within 1 year, accepts boiling hot, burn personnel 304 people altogether for medical treatment.Wherein, I degree burn and scald 189 people, shallow II degree burns 99 people, deep II degree burn and scald 54 people.For different types of burning, scald Hindering patient, be equally divided into 9 groups, the Oleum Hippophae that front 1-8 group uses embodiment 1-8 to provide respectively is scalded Medicine, external, once a day, and with smear Tonghua Maoxiang Pharmaceutical Co., Ltd. buy the auspicious burn and scald of cyclopentadienyl Cream contrasts, and experimental result is as shown in table 1.
Patient's average curative day statistics scalded by table one
As shown in Table 1, use medicament for treating scald provided by the present invention, contrast with existing medicament for treating scald, cure Time is short.Further, the pain of patient in use can substantially be reduced, after wound healing not Cicatrix can be left.And existing medicament for treating scald, do not ensure that patient cure after preventing from scar completely.
Experimental example 2 case
Case 1 Lee, 12 years old, man, the oil scald seethed with excitement, it is diagnosed as shallow II degree burn, makes The Oleum Hippophae medicament for treating scald provided by the embodiment of the present invention 6, is applied in affected part every night, after 1 day, Pain substantially alleviates, and after 3 days, blister disappears, and after 7 days, healing in affected part, after 9 days, affected part is all controlled Heal and without cicatrix.
Case 2 Wu, 54 years old, is diagnosed as shallow II degree burn, uses the embodiment of the present invention 7 institute The Oleum Hippophae medicament for treating scald provided, is applied in affected part every night, and after 1 day, pain substantially alleviates, 3 days Healing in rear affected part, after 6 days, affected part all cures and without cicatrix.
Case 3 Zhang, 33 years old, is diagnosed as deep ii degree burn, uses the embodiment of the present invention 8 institute The Oleum Hippophae medicament for treating scald provided, is applied in affected part every night, and after 2 days, pain substantially alleviates, 5 days Rear blister disappears, and affected part healing after 13 days, after 18 days, affected part all cures and without cicatrix.
In sum, the present invention provides a kind of Oleum Hippophae medicament for treating scald, to solve the healing of existing burn-scald medicine Time is long, and therapeutic effect is poor, and skin can leave the problems such as plain cicatrix.This Oleum Hippophae medicament for treating scald, There is instant effect, can substantially alleviate the advantages such as patient pain's sense, preventing from scar.The present invention provides The preparation method of Oleum Hippophae medicament for treating scald, obtains this Oleum Hippophae medicament for treating scald after the mixing of each raw material, homogenate, There is the advantages such as simple, convenient, easily operated, be suitable for being widely used.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that and do not carrying on the back May be made that in the case of the spirit and scope of the present invention many other change and amendment.Therefore, This means all these changes including belonging in the scope of the invention in the following claims and repair Change.

Claims (10)

1. an Oleum Hippophae medicament for treating scald, it is characterised in that include following group according to parts by weight preparation Point:
Fructrs Hippophae seed oil 50-80 part, Radix Arnebiae (Radix Lithospermi) 10-25 part, Borneolum Syntheticum 2-5 part.
Oleum Hippophae medicament for treating scald the most according to claim 1, it is characterised in that in terms of parts by weight, Also include: Aloe 10-20 part.
Oleum Hippophae medicament for treating scald the most according to claim 2, it is characterised in that in terms of parts by weight, Also include: Flos Lonicerae 5-10 part.
Oleum Hippophae medicament for treating scald the most according to claim 3, it is characterised in that in terms of parts by weight, Also include: Radix Et Rhizoma Rhei 2-10 part.
Oleum Hippophae medicament for treating scald the most according to claim 4, it is characterised in that in terms of parts by weight, Also include: Rhizoma Paridis 4-8 part.
Oleum Hippophae medicament for treating scald the most according to claim 5, it is characterised in that in terms of parts by weight, Also include: Radix Angelicae Sinensis 3-7 part.
7. according to a preparation method for the Oleum Hippophae medicament for treating scald described in any one of claim 1-6, its It is characterised by, comprises the following steps:
By other raw materials in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum and in powder according to set weight After number mixing, it is the seed of Fructus Hippophae of 75-85 DEG C that the material of mixing adds extremely set parts by weight and temperature In oil, after sizing mixing and being homogenized and get final product.
The preparation method of Oleum Hippophae medicament for treating scald the most according to claim 7, it is characterised in that tool Body comprises the following steps:
Raw material in addition to Fructrs Hippophae seed oil and Borneolum Syntheticum is dried to constant weight at 80-100 DEG C, according to Set parts by weight mix, pulverize, cross 80-140 mesh sieve, obtain pulverizing fines;Material by mixing Add to set parts by weight and Fructrs Hippophae seed oil that temperature is 75-85 DEG C, after sizing mixing and being homogenized I.e. obtain this Oleum Hippophae medicament for treating scald.
The preparation method of Oleum Hippophae medicament for treating scald the most according to claim 7, it is characterised in that institute Stating Oleum Hippophae uses the method for supercritical carbon dioxide extraction to prepare, and the mass fraction of described Oleum Hippophae For 50-80%.
The preparation method of Oleum Hippophae medicament for treating scald the most according to claim 7, it is characterised in that Described homogenate uses high-speed homogenization machine to carry out, and the rotating speed of homogenate is 7000-9000 rev/min, homogenate Time is 3-10 minute.
CN201610317482.2A 2016-05-12 2016-05-12 Sea buckthron oil-containing medicine for treating scalds, and preparation method of medicine Pending CN105902595A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108159203A (en) * 2017-12-23 2018-06-15 董晓 A kind of preparation method for the spray that scald is promoted to repair
CN113456735A (en) * 2021-06-02 2021-10-01 广州市锦盛生物科技有限公司 Inactivated probiotic herbal gel and preparation method and application thereof

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Publication number Priority date Publication date Assignee Title
CN1106697A (en) * 1994-10-18 1995-08-16 叶太华 Medicine for treatment of burn and scald and its preparation
CN1369293A (en) * 2002-01-11 2002-09-18 翟学礼 Chinese-medicinal ointment for treating burn and scald and its preparing process
CN101069725A (en) * 2006-05-09 2007-11-14 王桂欣 Ostrichoil for treating wound and burn and scald, and tibet medicine ointment and preparing method
CN103610888A (en) * 2013-12-16 2014-03-05 李晓 Ointment for treating burns and scalds and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1106697A (en) * 1994-10-18 1995-08-16 叶太华 Medicine for treatment of burn and scald and its preparation
CN1369293A (en) * 2002-01-11 2002-09-18 翟学礼 Chinese-medicinal ointment for treating burn and scald and its preparing process
CN101069725A (en) * 2006-05-09 2007-11-14 王桂欣 Ostrichoil for treating wound and burn and scald, and tibet medicine ointment and preparing method
CN103610888A (en) * 2013-12-16 2014-03-05 李晓 Ointment for treating burns and scalds and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108159203A (en) * 2017-12-23 2018-06-15 董晓 A kind of preparation method for the spray that scald is promoted to repair
CN113456735A (en) * 2021-06-02 2021-10-01 广州市锦盛生物科技有限公司 Inactivated probiotic herbal gel and preparation method and application thereof
CN113456735B (en) * 2021-06-02 2022-11-25 广州市锦盛生物科技有限公司 Inactivated probiotic herbal gel and preparation method and application thereof

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Application publication date: 20160831