CN105396120A - Drug for treating pox pits and pitting scars - Google Patents

Abstract

A drug for treating pox pits and pitting scars is composed of a component A and a component B. The component A is solid and contains mannitol, oligopeptides-1, oligopeptides-3, a cortex magnolia officinalis extract, a gastrodia elata extract, a semen aesculi extract, a curcuma aromatica extract, a rhizoma sparganii extract, a barberry root extract, an aster tataricus extract, a fructus sophorae extract and an angelica sinensis extract. The component B is liquid and contains water, ethylhexylglycerin, sodium hyaluronate, saccharomycetes fermentation cell lysis product filtrate, a herba lycopi extract, a poria cocos extract, a scutellaria baicalensis extract, a rhizoma kaempferiae extract, a golden cypress extract, a morinda officinalis extract, a gentiana macrophylla extract, a cortex eucommiae extract, a cowherb seed extract, a flatstem milkvetch seed extract, a grand torreya seed extract, a licorice extract, a flores aurantii extract, a cananga odorata extract and an aloe extract.

Description

A kind of medicine for the treatment of pox hole and depressed scar

Technical field

The present invention relates to a kind of medicine, especially a kind of medicine for the treatment of pox hole and depressed scar.

Background technology

Acne is that a kind of chronic inflammatory skin on pilosebaceous unit is sick, owing to being mainly in teenager, also claims comedo.The factors such as the generation of acne is main and hypersteatosis, pilosebaceous duct block, bacteriological infection and inflammatory reaction are closely related.If acne, between convalescence, skin injury occurs, pox hole and other depressed scar can be formed, can produce serious influence to the psychology of people and social activity.The most effective method of current treatment pox hole and depressed scar is the operation of laser mill skin, but this method price is very high, also very large to the injury of skin.Can repair the medicine of depressed scar on the market usually also containing certain hormone, and the Drug therapy cycle is longer, side effect is larger.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of pox hole and depressed scar, fully natural green environmental protection, not containing hormone, can promote defective tissue cell regeneration, be conducive to the growth of skin depressions place cell.Described medicine is made up of prescription A and prescription B,

Prescription A is solid forms, and its material composition and the parts by weight of each material in this prescription are:

Mannitol 11-19 part, oligopeptide-14-12 part, oligopeptide-34-12 part, Cortex Magnoliae Officinalis extract 8-16 part, Rhizoma Gastrodiae extract 6-14 part, Horse chest Nut P.E 24-32 part, Radix Curcumae extract 12-20 part, Rhizoma Sparganii extract 4-12 part, Radix Berberidis extract 32-40 part, Radix Asteris extract 12-20 part, Fructus Sophorae extract 6-14 part, Radix Angelicae Sinensis extract 4-12 part;

Prescription B is liquid form, and its material composition and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 35-65 part, hyaluronate sodium 14-26 part, yeast fermentation lysate filtrate 28-44 part, Herba Lycopi extract 14-22 part, Poria extract 4-12 part, Radix Scutellariae extract 4-12 part, Rhizoma Kaempferiae extract 20-28 part, Cortex Phellodendri extract 8-16 part, Radix Morindae Officinalis extract 4-12 part, Radix Gentianae Macrophyllae extract 4-12 part, Cortex Eucommiae extract 32-40 part, Semen Vaccariae extract 14-22 part, Semen Astragali Complanati extract 28-36 part, Semen Torreyae extract 8-16 part, Radix Glycyrrhizae extract 18-26 part, orange blossom extract 2-10 part, Cananga odorata extract 2-10 part, Aloe extract 2-10 part.

As the preferred technical scheme of one of the present invention,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 13-17 part, oligopeptide-16-10 part, oligopeptide-36-10 part, Cortex Magnoliae Officinalis extract 10-14 part, Rhizoma Gastrodiae extract 8-12 part, Horse chest Nut P.E 26-30 part, Radix Curcumae extract 14-18 part, Rhizoma Sparganii extract 6-10 part, Radix Berberidis extract 34-38 part, Radix Asteris extract 14-18 part, Fructus Sophorae extract 8-12 part, Radix Angelicae Sinensis extract 6-10 part;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 40-60 part, hyaluronate sodium 16-24 part, yeast fermentation lysate filtrate 32-40 part, Herba Lycopi extract 16-20 part, Poria extract 6-10 part, Radix Scutellariae extract 6-10 part, Rhizoma Kaempferiae extract 22-26 part, Cortex Phellodendri extract 10-14 part, Radix Morindae Officinalis extract 6-10 part, Radix Gentianae Macrophyllae extract 6-10 part, Cortex Eucommiae extract 34-38 part, Semen Vaccariae extract 16-20 part, Semen Astragali Complanati extract 30-34 part, Semen Torreyae extract 10-14 part, Radix Glycyrrhizae extract 20-24 part, orange blossom extract 4-8 part, Cananga odorata extract 4-8 part, Aloe extract 4-8 part.

As the preferred technical scheme of one of the present invention,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 15 parts, oligopeptide-18 parts, oligopeptide-38 parts, Cortex Magnoliae Officinalis extract 12 parts, Rhizoma Gastrodiae extract 10 parts, Horse chest Nut P.E 28 parts, Radix Curcumae extract 16 parts, Rhizoma Sparganii extract 8 parts, Radix Berberidis extract 36 parts, Radix Asteris extract 16 parts, Fructus Sophorae extract 10 parts, Radix Angelicae Sinensis extract 6 parts;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 50 parts, hyaluronate sodium 20 parts, yeast fermentation lysate filtrate 36 parts, Herba Lycopi extract 18 parts, Poria extract 8 parts, Radix Scutellariae extract 8 parts, Rhizoma Kaempferiae extract 24 parts, Cortex Phellodendri extract 12 parts, Radix Morindae Officinalis extract 8 parts, Radix Gentianae Macrophyllae extract 8 parts, Cortex Eucommiae extract 36 parts, Semen Vaccariae extract 18 parts, Semen Astragali Complanati extract 32 parts, Semen Torreyae extract 12 parts, Radix Glycyrrhizae extract 22 parts, orange blossom extract 6 parts, Cananga odorata extract 6 parts, Aloe extract 6 parts.

The extracting method of described Cortex Magnoliae Officinalis extract, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, Radix Berberidis extract is: clean, chopping, and by acetic acid reflux, extract, 3-5 time, merge extractive liquid, vacuum drying, to obtain final product.

The extracting method of described Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, Radix Angelicae Sinensis extract is: clean, chopping, and refined honey mixing post-heating is to 45-65 DEG C, insulation 3-5h, using water as solvent after cooling, uses ultrasonic extraction 3-6h, filtration final vacuum is dry, to obtain final product.

The extracting method of described Cortex Phellodendri extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract is: clean, chopping, with alcohol reflux 3-5 time, merge extractive liquid, concentrates and obtains fluid extract.

The extracting method of described Herba Lycopi extract, Poria extract, Radix Scutellariae extract, Rhizoma Kaempferiae extract is: clean, and chopping, using water as solvent, uses ultrasonic extraction 3-6h, concentrates and obtain fluid extract after filtering.

The extracting method of described Cortex Eucommiae extract, Semen Vaccariae extract, Semen Astragali Complanati extract, Semen Torreyae extract is: clean, and Testa Tritici fries 0.5-1h, and temperature is 120-130 DEG C, Testa Tritici is filtered after cooling, using ethanol as solvent, use ultrasonic extraction 3-6h, concentrate after filtering and obtain fluid extract.

Described Radix Glycyrrhizae extract, orange blossom extract, Cananga odorata extract, Aloe extract are obtained by supercritical carbon dioxide extraction, and extraction temperature is 30-35 DEG C, and extracting pressure is 18-25MPa, and resolution temperature is 42-53 DEG C, and parsing pressure is 5-7MPa.

A using method for the medicine of above-mentioned treatment pox hole and depressed scar, by described solids and liquid object with weight ratio 1:(50-75) directly smear to desired area after mix homogeneously.

Be more conducive to understand foregoing of the present invention, advantage and feature with reference to following detailed description.

Detailed description of the invention

Unless otherwise defined, all technology used herein and scientific terminology have the identical implication usually understood with one skilled in the art of the present invention.When there is contradiction, be as the criterion with the definition in this description.

During the Range Representation that equivalent, concentration or other value or parameter limit with scope, preferable range or a series of upper limit preferred value and lower preferable values, this is appreciated that all scopes specifically disclosing and formed by arbitrary pairing of any range limit or preferred value and any range lower limit or preferred value, no matter and whether this scope separately discloses.Such as, when disclosing scope " 1 to 5 ", described scope should be interpreted as comprising scope " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-3 and 5 " etc.When numerical range is described in this article, unless otherwise indicated, otherwise this scope intention comprises its end value and all integers within the scope of this and mark.

Term " refined honey " refers to: put by Mel in pot, after being heated to boiling slowly, using slow fire instead, keep micro-and boil, and scumming and floating waxiness, then with sieve sieve or the dead honeybee of gauze elimination, impurity, then in impouring pot, 116 DEG C-118 DEG C are heated to, panful plays flake bubble, with the toughness of hands sth. made by twisting, two refer between there is no long white silk when occurring, take the dish out of the pot rapidly.

Treat a medicine for pox hole and depressed scar, be made up of prescription A and prescription B,

Prescription A is solid forms, and its material composition and the parts by weight of each material in this prescription are:

Mannitol 11-19 part, oligopeptide-14-12 part, oligopeptide-34-12 part, Cortex Magnoliae Officinalis extract 8-16 part, Rhizoma Gastrodiae extract 6-14 part, Horse chest Nut P.E 24-32 part, Radix Curcumae extract 12-20 part, Rhizoma Sparganii extract 4-12 part, Radix Berberidis extract 32-40 part, Radix Asteris extract 12-20 part, Fructus Sophorae extract 6-14 part, Radix Angelicae Sinensis extract 4-12 part;

Prescription B is liquid form, and its material composition and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 35-65 part, hyaluronate sodium 14-26 part, yeast fermentation lysate filtrate 28-44 part, Herba Lycopi extract 14-22 part, Poria extract 4-12 part, Radix Scutellariae extract 4-12 part, Rhizoma Kaempferiae extract 20-28 part, Cortex Phellodendri extract 8-16 part, Radix Morindae Officinalis extract 4-12 part, Radix Gentianae Macrophyllae extract 4-12 part, Cortex Eucommiae extract 32-40 part, Semen Vaccariae extract 14-22 part, Semen Astragali Complanati extract 28-36 part, Semen Torreyae extract 8-16 part, Radix Glycyrrhizae extract 18-26 part, orange blossom extract 2-10 part, Cananga odorata extract 2-10 part, Aloe extract 2-10 part.

As the preferred technical scheme of one of the present invention,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 13-17 part, oligopeptide-16-10 part, oligopeptide-36-10 part, Cortex Magnoliae Officinalis extract 10-14 part, Rhizoma Gastrodiae extract 8-12 part, Horse chest Nut P.E 26-30 part, Radix Curcumae extract 14-18 part, Rhizoma Sparganii extract 6-10 part, Radix Berberidis extract 34-38 part, Radix Asteris extract 14-18 part, Fructus Sophorae extract 8-12 part, Radix Angelicae Sinensis extract 6-10 part;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 40-60 part, hyaluronate sodium 16-24 part, yeast fermentation lysate filtrate 32-40 part, Herba Lycopi extract 16-20 part, Poria extract 6-10 part, Radix Scutellariae extract 6-10 part, Rhizoma Kaempferiae extract 22-26 part, Cortex Phellodendri extract 10-14 part, Radix Morindae Officinalis extract 6-10 part, Radix Gentianae Macrophyllae extract 6-10 part, Cortex Eucommiae extract 34-38 part, Semen Vaccariae extract 16-20 part, Semen Astragali Complanati extract 30-34 part, Semen Torreyae extract 10-14 part, Radix Glycyrrhizae extract 20-24 part, orange blossom extract 4-8 part, Cananga odorata extract 4-8 part, Aloe extract 4-8 part.

As the preferred technical scheme of one of the present invention,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 15 parts, oligopeptide-18 parts, oligopeptide-38 parts, Cortex Magnoliae Officinalis extract 12 parts, Rhizoma Gastrodiae extract 10 parts, Horse chest Nut P.E 28 parts, Radix Curcumae extract 16 parts, Rhizoma Sparganii extract 8 parts, Radix Berberidis extract 36 parts, Radix Asteris extract 16 parts, Fructus Sophorae extract 10 parts, Radix Angelicae Sinensis extract 6 parts;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 50 parts, hyaluronate sodium 20 parts, yeast fermentation lysate filtrate 36 parts, Herba Lycopi extract 18 parts, Poria extract 8 parts, Radix Scutellariae extract 8 parts, Rhizoma Kaempferiae extract 24 parts, Cortex Phellodendri extract 12 parts, Radix Morindae Officinalis extract 8 parts, Radix Gentianae Macrophyllae extract 8 parts, Cortex Eucommiae extract 36 parts, Semen Vaccariae extract 18 parts, Semen Astragali Complanati extract 32 parts, Semen Torreyae extract 12 parts, Radix Glycyrrhizae extract 22 parts, orange blossom extract 6 parts, Cananga odorata extract 6 parts, Aloe extract 6 parts.

Cortex Magnoliae Officinalis is Magnoliaceae, magnolia, is used as medicine with dried bark, root bark and branch skin, bitter in the mouth, pungent, warm in nature, returns spleen, stomach, lung, large intestine channel.Cortex Magnoliae Officinalis contains Neolignans, such as: magnolol, and honokiol, the new phenol of magnolia obovata, 6 '-O-methyl honokiol, Cortex Magnoliae Officinalis aldehyde B, C, Cortex Magnoliae Officinalis lignan A, B, C, D, E and Taiwan sassafrases aldehyde; Also containing monoterpene Neolignans, such as: Mentha piperita base magnolol, two Mentha piperita base magnolol, Mentha piperita base honokiol and imperial born of the same parents' base magnolol; Also containing falling Neolignans, such as: Taiwan sassafrases phenol, Cortex Magnoliae Officinalis triphenol B, magnaldehyde D, E; Also containing two Neolignans, such as: Cortex Magnoliae Officinalis lignan F, G, H and I; Also containing alkaloid, such as: magnocurarine and salicifoline; Also containing volatile oil, such as: sagittol, cubebol, guaiol, cymol, Isosorbide-5-Nitrae-cineole, Flos Caryophylli alkene, linalool, α-terpinene, α-Humuleno, 4-terpinenol, globulol and α-limonene; Also containing also containing sinapyladehyde, syringaresinol, syringaresinol-4 '-O-β-D-glucopyanoside and 1-(4-hydroxy 3-methoxybenzene base)-2-[4-(ω-hydroxypropyl)-2-methoxyphenoxy]-1,3-PD.Have dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full effect.

Rhizoma Gastrodiae is the orchid family Gastrodia herbaceos perennial, is used as medicine with rhizome, sweet in the mouth, and property is put down, and returns Liver Channel.The main component that in Rhizoma Gastrodiae, content is higher is gastrodin, also claims gastrodine, and its chemical composition is p-methylol benzene-β-D-glucopyanoside; Another containing Rhizoma Gastrodiae ether glycoside, its chemical composition is two-(4-acrinyl)-ether-mono--β-D-glucopyanoside.Again containing p-hydroxyphenylmethyl alcohol, para hydroxybenzene methyl aldehyde, 4-acrinyl methyl ether, 4-(4'-hydroxyl benzyloxy) methyl benzyl ether., two (4-acrinyl) ether, three [4-(β-D-glucopyra glycosyloxy base) benzyl] citron acid esters.There is effect of endogenous wind stopping relieving convulsion, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.

Semen Aesculi is the dry mature seed of Hippocastanaceae plant Aesculus chinensis Bunge, and sweet in the mouth is warm in nature, returns liver, stomach warp.The fatty oil of Semen Aesculi, starch, fiber, crude protein.Fatty oil is mainly oleic acid and stearic glyceride.There is regulating the flow of QI to ease the stomach, and effect of stomach and alleviating pain.

Radix Curcumae is the tuber of zingiberaceous plant RADIX CURCUMAE, not the tuber of zingiberaceous plant Rhizoma Curcumae Longae or zingiberaceous plant Rhizoma Curcumae, and acrid in the mouth, hardship are cool in nature.Radix Curcumae main component is volatile oil, camphene, Camphora, sesquiterpene, curcumene, sesquiterpene alcohols.Also containing curcumin, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone.Separately starch-containing, fatty oil, weld, Eucarvone and phellandrene.There is removing heat from blood clear away heart-fire, stasis-dispelling and pain-killing, promoting QI circulation for relieving depression, effect of promoting the function of the gallbladder to alleviate jaundice.

Rhizoma Sparganii is the tuber of Sparganiaceae plant rhizoma scirpi, acrid in the mouth, hardship, and property is put down.The main chemical compositions of Rhizoma Sparganii is phenethanol, hydroquinone, hexadecylic acid; also have dehydrocostuslactone, 3,4-dihydro-8-hydroxy-3-methyl-1H-2-benzopyran-4-ones, 1-hydroxyl-2-acetyl group-4-methylbenzene, beta-elemene, 2-furan alcohol, 2-acetyl pyrrole etc.Also containing multiple organic acid, such as: succinic acid, Rhizoma Sparganii acid, 9,11-octadecadienoic acid, 9,12-octadecadienoic acids, 10-nonadecenoic acid, 11-eicosenoic acid, benzoic acid, 3-benzene-2-acrylic acid, decanedioic acid and the fatty acid containing C8-C10, C12, C14-C20.Also containing formoononetin, stigmasterol, cupreol, daucosterol.There is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving.

Radix Berberidis is root bark or the peel of stem that Berberidaceae plant stings black pearl, berberis brachypoda Maxim, black stone pearl etc.Bitter in the mouth, cold in nature, return liver, stomach, large intestine channel.Radix Berberidis is containing quaternary amines alkaloid: berberine, jateorhizine, palmatine, Columbamine, magnoflorine; Tertiary amines alkaloid: berbamine etc.There is heat clearing and damp drying, effect of eliminating fire and detoxication.

Radix Asteris is feverfew Radix Asteris, is used as medicine with root and rhizome, acrid in the mouth, hardship, warm in nature, returns lung meridian.Main containing freidelin alcohol, freidelin, shionon, astersaponin, Quercetin, containing lachnophyllol, acetic acid hair leaf ester, methoxybenzene, hydrocarbon, fatty acid, aromatic acid in volatile oil.There is nourishing the lung to keep the adverse QI downward, effect of stopping coughing and removing phlegm.

The Fructus Sophorae is leguminous plant Chinese scholartree, with fruit medicine, and bitter in the mouth, cold in nature, return liver, large intestine channel.Main containing flavone compound, genistein, genistein-7-β-D-cellobiose glycoside, genistein-7-glucosulfone base rhamnoside, kaempferol, kaempferol-3-O-rhamanopyranosyl diglucoside, kaempferol-3,7-O-diglucoside, Quercetin, globulariacitrin, sophoricoside, genistein-4'-glucosidorhamnoside., sophoraflavonoloside.Also containing the free amino acid such as triterpenoid compound and lysine, Radix Asparagi acid amide, arginine, serine, glutamic acid, threonine, alanine, proline, tryptophan, valine, phenylalanine, leucine, isoleucine.Also containing alkaloid, such as: eulexine, N-Methylcytisine, sophocarpine, matrine, stizolamine.Also containing galactomannan, phospholipid and phytin., phytohaemagglutinin etc.Also containing oleic acid, linoleic acid, linolenic acid, Palmic acid, stearic acid, octadecenoic acid, octadecadienoic acid, jeceric acid.There is clearing away heat-fire, effect of cooling blood for hemostasis.

When being classified as umbelliferae angelica, be used as medicine with root, sweet in the mouth, pungent, warm in nature, return liver, the heart, spleen channel.Radix Angelicae Sinensis is mainly containing butylidenephthalide, the positive the eleventh of the twelve Earthly Branches ketone of adjacent carboxyl benzene, δ-2,4-dihydro acid phthalic anhydride, sucrose, vitamin B12, vitamin A, oleic acid, linoleic acid, sitosterol, ligustilide, ferulic acid, succinic acid, scopoletin, umbelliferone, vanillic acid, choline, sickleleaf celery alcohol, sickleleaf celery ketone, falcarindiol, uracil, adenine, several amino acids and lot of trace metallic element, as calcium, copper, zinc, ferrum, potassium.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.

Herba Lycopi is labiate hair leaf lycopus lucidus, is used as medicine with stem and leaf, bitter in the mouth, pungent, warm in nature, returns liver, spleen channel.Main containing volatile oil, glycoside, tannin and resin, also containing flavonoid glycoside, phenols, aminoacid, organic acid, Saponin, glucose, galactose, Herba Lycopi's sugar, sucrose, Raffinose, stachyose, fructose.There is tonifying liver purgation of spleen excess, and QI and blood, effect of Li Jinmai.

Poria is On Polyporaceae Poria, is used as medicine with sclerotium, and property is put down, sweet in the mouth, GUIXIN, lung, spleen channel.Poria main component is triterpenoid compound, pachymic acid, 16 Alpha-hydroxy eburicoic acids, 3 beta-hydroxies-7,9 (11), 24-Pilus Caprae seu Ovis steroid triolefin-21-acid, pachymic acid methyl ester, 16 Alpha-hydroxy eburicoic acid methyl ester, 7,9 (11)-DHPA methyl ester, 3 β, 16 alpha-dihydroxy-s-7,9 (11), 24 (31)-Pilus Caprae seu Ovis steroid triolefin-21-acid methyl ester, total triterpenes methyl ester, the acid of 3-hydrogenation pine Siberian cocklebur, eburicoic acid, dehydroeburicoic acid, Poria eo-acid, β-aromadendrol acetic acid, 7,9 (11) DHPAs.Polysaccharide, pachyman, Poria time poly-, callose H11.Other, ergosterol, sad, caprylate, hendecanoic acid, lauric acid, lauric acid ester, Palmic acid, dodecylene acid esters and inorganic elements.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.

Radix Scutellariae is labiate Radix Scutellariae, is used as medicine with root, and bitter in the mouth is cold in nature, returns lung, gallbladder, spleen, large intestine, small intestine meridian.Containing flavone compound: baicalin, neobaicalein, baicalin, wogonin, wogonoside, oroxylin A, 7-methoxyl group baicalin, skullcapflavone, dihydro oroxylin A, chrysin, 2,5,8-trihydroxy-7-methoxy flavone, 2,5,8-trihydroxy-6,7-dimethoxy flavone, 4,5,7-trihydroxy-6-methoxy flavanone, 2,3,5,6,7-penta hydroxy group flavanone, wogonin-5-β-D-Glucose glycoside, 2-(3-hydroxyl-4-methoxyphenyl)-ethyl-1-O-α-L-rhamanopyranosyl (1 → 3)-β-D (4-Resina Ferulae acyl group)-glucose, chrysin-6-C-α-L-arabinose glycoside, chrysin-6-C-α-L-arabinose glycoside-8-C-β-D-Glucose glycoside, (2S)-2,5,6,7-tetrahydroxy flavanone, 5,7,2,6-kaempferol, 5,8-dihydroxy-6,7-dimethoxy flavone, 5,7,4-trihydroxy-8-methoxy flavone, oroxylin A-7-O-glucuronide, 5,7,2-trihydroxy methoxy flavone, 5,2-dihydroxy-6,7,8-trimethoxy flavone, Norwogonin, dihydro baicalin, 5,7,2-trihydroxyflavone, 5,7,2-trihydroxy-8,6-dimethoxy flavone, 5,7,2,5-tetrahydroxy-8,6-dimethoxy flavone, 5,2,5-trihydroxy trimethoxy flavone, baicalin-7-O-β-D-glucopyanoside, 5,7,2-trihydroxy-8-methoxy flavone, 5,2,6-trihydroxy-7,8-dimethoxy flavone, 5,2,6-trihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one, 5,7,2,3-kaempferol, 3,5,7,2,5,6-pentahydroxyflavone, (2S)-7,2,6-trihydroxy-5-methoxy flavanone, 2,6,2,4-tetrahydroxy-6-methoxyl group chalcone, 5,7,2,5-kaempferol, left-handed eriodictyol, Herba Scutellariae Barbatae kind element, 2-O-β-D-glucopyanoside.Also containing cupreol, campesterol and stigmasterol.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.

Rhizoma Kaempferiae is many Zingiberaceaes Kaempferia Rhizoma Kaempferiae, is used as medicine with rhizome, and acrid in the mouth is warm in nature, returns spleen, stomach warp.Chemical composition has kaempferide, the composition of Rhizoma Kaempferiae volatile oil has that cinnamic acid second vinegar, p-methoxycinnamic acid, p-methoxycinnamic acid second are cruel, cinnamic acid isopropyl vinegar, cyclohexyl-acetic acid second are cruel, 3,7-dimethoxy coumarin, hendecanone, 2-heptadecanone, 9-hydroxyl-methyl n-heptyl ketone, 10-undecyne-1-alcohol, benzene alkene, Borneolum Syntheticum etc.There is warming middle-JIAO for eliminating dampness, effect of promoting the circulation of QI to relieve pain.

Cortex Phellodendri is rutaceae wampee, is used as medicine with bark, and bitter in the mouth is cold in nature, returns kidney, urinary bladder channel.Alkali, guanidine is appointed containing berberine, phellodendrine, magnoflorine, jateorhizine, palm leaf coculine, candicine, Caulis menispermi; Another containing limonin, obacunone, clionasterol, cupreol, campesterol, stigmasterol, 7-Dehydrostigmaslerol, Dictamnolide, obacunonic acid, the acid of blue or green fluorescent, 24-methylene basic ring jackfruit alcohol, γ-hydroxyl butylene lactone derivatives, Fici hispidae alcohol-B, berberrubine.Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.

Radix Morindae Officinalis is Maguireothamnus speciosus Radix Morindae Officinalis, is used as medicine with root, and sweet in the mouth is pungent, warm in nature, returns kidney, Liver Channel.Main containing Rubiadin, Rubiadin 1-methylether, physcione, 2-hydroxyl methylol anthraquinone, 1-hydroxyanthraquinone, 1-hydroxy-2-methyl anthraquinone, 1,6-dihydroxy-2,4-dimethoxy anthraquinone, 1,6-dihydroxy-2-methoxy anthraquinone, 2-methylanthraquinone, Monotropein, four acetyl rubichloric acid .s.Also containing glucose, mannose, cupreol, Palmic acid, vitamin C, nonadecane, 24-ethyl cholesterol.There is reinforcing the kidney and supporting YANG, bone and muscle strengthening, effect of expelling wind and removing dampness.

Radix Gentianae Macrophyllae is gentianaceae plant Radix Gentianae Macrophyllae, is used as medicine with root, acrid in the mouth, hardship, and property is put down, and returns stomach, liver, gallbladder meridian.Main containing gentianin, gentianidine, gentianal, swertiamarin, montanic acid, montanic acid methyl ester, roburic acid, α-Amyrin, cupreol, cupreol-β-D-Glucose glycoside.Have and have wind-damp dispelling, clearing away damp-heat, stopping numbness pain, effect of reducing the asthenic fever.

The Cortex Eucommiae is the Eucommiaceae plant Cortex Eucommiae, is used as medicine with bark, and sweet in the mouth is warm in nature, returns liver, kidney channel.Main containing dextrorotation syringaresinol, dextrorotation balsam phenol glycoside, Flos Caryophylli glycerol-β-syringaresinol ether 4 ', 4 ' ' '-bis-glycoside, dextrorotation pinoresinol, dextrorotation table pinoresinol, dextrorotation pinoresinol glycoside, the two glycoside of dextrorotation pinoresinol, dextrorotation 1-hydroxyl pinoresinol, dextrorotation 1-hydroxyl pinoresinol-4 '-glycoside, dextrorotation 1-hydroxyl pinoresinol-4 ' '-glycoside, dextrorotation 1-hydroxyl pinoresinol-4 ', 4 ' '-bis-glycoside, Dihydrodehydodiconiferyl alcohol, Soviet Union's formula dihydroxy dehydrodiconiferylalcohol, erythro form dihydroxy dehydrodiconiferylalcohol, dehydrodiconiferylalcohol-4, r '-diglucoside, left-handed olivil, left-handed olivil-4 '-glycoside, left-handed olivil-4 ' '-glycoside, left-handed olivil-4 ', 4 ' '-bis-glycoside, dextrorotation ring olivil, dextrorotation Cortex Eucommiae Syringaresinol, Cortex Eucommiae element A, the two glycoside of dextrorotation Cortex Eucommiae Syringaresinol, Auricled Hedyotis Herb lipidol C-4 ' ', 4 ' '-bis-glycoside, Liriodendron glycoside, Citrus chachiensis Hort. belongs to glycoside B, aucubin, eucommito, all square rafter elements, all square rafter glycosides, all square rafter glycoside acid, ajugoside, harpagide acetas, bugle glycoside, eucommoil, eucommoil glycoside I, caffeic acid, chlorogenic acid, methyl chlorogenate, vanillic acid, betulin, betulic acid, ursolic acid, cupreol, daucosterol, phenylalanine, lysine, tryptophan, methionine, threonine, valine, leucine, isoleucine, glutamic acid, cystine, histidine, Cortex Eucommiae enol, nimbecetin, tartaric acid, galactitol, N-triacontanol, positive nonacosane, gutta-percha.There is invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.

Semen Vaccariae is pinkwort Vaccaria segetalis, is used as medicine with seed, bitter in the mouth, and property is put down, and returns liver, stomach warp.Main containing vacsedoside A, B, C, D, Semen Vaccariae flavonoid glycoside, isosaponaretin, phytin., phospholipid, stigmasterol, Semen Vaccariae xanthone, Vaccaria segetalis xanthone, 1,8-dihydroxy-3,5-dimethoxy 9-xanthone.There is promoting blood circulation to restore menstrual flow, effect of stimulating milk secretion detumescence.

Semen Astragali Complanati is the flat stem Radix Astragali of leguminous plant, is used as medicine with seed, and sweet in the mouth is warm in nature, returns liver, kidney channel.Main containing sucrose, glucuronic acid, phlegmatic temperament, aminoacid, bitter principle, choline, betanin, folic acid, 2 ', 4 '-dihydroxy-5,6-dimethoxy isoflavan, kumatakenin, linoleic acid, linolenic acid, cupreol.There is the liver and the kidney tonifying, effect of improving eyesight controlling nocturnal emission with astringent drugs.

Semen Torreyae is taxaceae plant Chinese torreya, is used as medicine with seed, sweet in the mouth, and property is put down, and returns lung, stomach, large intestine channel.Main containing Palmic acid, stearic acid, oleic acid, linoleic glyceride, sterol, oxalic acid, glucose, polysaccharide, volatile oil, tannin.There is killing insect and eliminating accumulation, nourishing the lung to arrest cough, effect of moistening dryness for relaxing bowels.

Radix Glycyrrhizae is glycyrrhizic legume, is used as medicine with rhizome, sweet in the mouth, and property is put down, GUIXIN, lung, spleen, stomach warp.Radix Glycyrrhizae root welding technology master is containing triterpenoid saponin.Wherein main one, being commonly called as glycyrrhizin, is the sweet ingredient of Radix Glycyrrhizae, is potassium salt and calcium salt that the 18 β-enoxolone of 1 molecule and the glucuronic acid of 2 molecules combine the glycyrrhizic acid generated.Other triterpenoid saponin has: uralsaponin A, B and glycyrrhizin A ₃, B ₂, C ₂, D ₃, E ₂, F ₃, G ₂, H ₂, J ₂, K ₂.Again containing flavone compounds: liquiritigenin, liquiritin, Isoliquiritigenin, isoliquiritin, neoliquriitin, close isoliquiritin, licoricidin (+)-Licoricidin., Licoricone, formoononetin, this fixed, liquiritigenin-4 of 5-O-methyl Radix Glycyrrhizae '-celery sugar glycoside, liquiritigenin-7, namely 4 '-diglucoside, vicenin-2 are 6,8-, bis--glucosyl group apigenin, ononin, Isolicoflavonol., Isoliquiritigenin-4 '-celery sugar Fructus Vitis viniferae glycoside.Also containing Coumarins compound: Radix Glycyrrhizae coumarin, glycyol, isoglycyol, Radix Glycyrrhizae coumarin-7-methyl ether, neoglycyrol, Radix Glycyrrhizae pyrans coumarin, licocoumarone etc.Again containing alkaloid: 5,6,7,8-tetrahydrochysene-4-methylquinoline, 5,6,7,8-tetrahydrochysene-2,4-dimethyl quinolines, 3-methyl-6,7,8-tri-hydrogen pyrrolo-[1,2-a] pyrimidine-3-ketone.Also containing licobenzofuran, have another name called liconeolignan, cupreol, n-tricosane, n-hexacosane, heptacosane etc.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, effect of relieving spasm to stop pain.

Orange blossom is the flower of Rutaceae bigarabe, mainly containing limonene, linalool, geraniol, nerol, aldehyde, methyl 2-aminobenzoate, Hesperidin, rutin, naringin.

Fragrant cananga is annonaceae fragrant cananga platymiscium, be used as medicine with flower, mainly containing linalool, geraniol, nerol, terpineol, benzyl alcohol, phenethanol, folic alcohol, eugenol, paracresol, paracresol ether, safrole, isosafrole, methyl heptenone, valeric acid, benzoic acid, salicylic acid, geranyl acetate, methyl salicylate, pinene, farnesene, caryophyllene.

Aloe is liliaceous plant Aloe vulgaris, is used as medicine with leaf, and bitter in the mouth is cold in nature, returns liver, stomach, large intestine channel.Aloe is mainly containing aloin, different aloin, 7-hydroxyl aloin, 5-hydroxyl aloin A, resin, altheine, aspartic acid, DL-threonine, L-Trp, cholesterol, campesterol, cupreol, lupeol, malic acid, citric acid, tartaric acid, D-Glucose, D-MANNOSE, pectic acid, D-galactan, arabinose and rhamnose.There is eliminating fire and detoxication, effect of blood stasis dispelling parasite killing.

Mannitol, is also called PEARLITOL 25C, hexanhexol, and be white orthorhombic system acicular crystal, sugariness is about the 57%-72% of Saccharum Sinensis Roxb..Mannitol can be prepared by nickel catalysis, such as: reduced under Raney nickel effect at the temperature of 5-15MPa air pressure and 120-150 DEG C by the sucrose solution of 50%.

Mannitol also can extract from natural plants.Such as: the Thallus Laminariae (Thallus Eckloniae) of fresh (or dry or through soak) or the mucus on Sargassum surface are washed down, with alkali precipitation, filter, filtrate is through acidify, filtration, and filtrate is obtained thick product after concentrated.By thick product washing with alcohol, recrystallization in water, to obtain final product.

Mannitol also can be obtained by electrolytic method.Such as: with sucrose or glucose for raw material, being made into electrolyte with sodium sulfate, with amalgamate stereotype for negative electrode, take stereotype as anode, take porous ceramics as barrier film, carry out electrolysis, the mixed liquor of mannitol and Sorbitol can be obtained, then the two is made to be separated, refining, to obtain final product.

Oligopeptide is the linear peptides be connected to form by peptide bond by 2-6 aminoacid, and molecular weight section, generally below 1000 dalton, does not need digestion at human body, can directly absorb.Oligopeptide is selected from least one in oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, oligopeptide-6.As a kind of preferred technical scheme of the present invention, described oligopeptide is selected from the compositions of oligopeptide-1 and oligopeptide-3.

Sensiva SC50 is moderate emollient, wetting agent and the wetting agent of a kind of spreading property.Soft and smooth skinfeel can be had again while raising formula moisturizing effect, the growth and breeding of the antibacterial causing abnormal flavour can be suppressed simultaneously, there is deodorizing effect.In addition, Sensiva SC50 does not affect by hydrolysis, temperature and pH value, prepares burden compatible with other.

A kind of high polymer that hyaluronic acid is made up of the disaccharidase recurring unit of (1 → 3)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-β-D-Glucose-(1 → 4)-O-β-D-Glucose aldehydic acid is acid mucopolysaccharides.Hyaluronate sodium forms a kind of sticky elastic solution in water, has physiology acid-base value and ionic strength.Can be extracted by cockscomb and umbilical cord and be obtained.Such as: chop up after being washed by fresh cockscomb 10kg, add the sodium hydroxide solution of doubling dose, be uniformly mixed at 60 DEG C and extract 30min, then with trichloroacetic acid solution neutralization, catalase is added by residual peroxide decomposition.Then remove Deproteinization with trichloroacetic acid, make the trichloroacetic acid concentration of extracting solution become 5%.After filtration, with the sodium hydroxide solution neutralization of 10 % by weight, after 24h that it is dialysed in flowing water, filter.Obtain the filtrate of about 15L, after its heat sterilization, about add the dehydrated alcohol of 45L, be uniformly mixed, obtain after the precipitate of precipitation is filtered.

Yeast fermentation lysate filtrate obtains lysate by breaking cellular wall after culture propagation to obtain after filtration.Wherein amino acid content more than 30%, total protein more than 50%, nucleotide more than 10%, has the effect such as moisturizing, activation.Aminoacid is the main component of natural Moisture factor in keratodermatitis, is easily absorbed by the skin, and makes aging epidermis recover elasticity, delay skin aging.Nucleic acid and nucleotide are the central genetic materials of human body, have enhancing metabolism, improve the effects such as protein synthesis speed, strengthen immune function, superoxide dismutase activity improving, improve skin antiradical activities.In addition, the nutrients such as wherein a small amount of vitamin and mineral can also provide sufficient nutrition for skin.

The extracting method of described Cortex Magnoliae Officinalis extract, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, Radix Berberidis extract is: clean, chopping, and by acetic acid reflux, extract, 3-5 time, merge extractive liquid, vacuum drying, to obtain final product.

The extracting method of described Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, Radix Angelicae Sinensis extract is: clean, chopping, and refined honey mixing post-heating is to 45-65 DEG C, insulation 3-5h, using water as solvent after cooling, uses ultrasonic extraction 3-6h, filtration final vacuum is dry, to obtain final product.

The extracting method of described Cortex Phellodendri extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract is: clean, chopping, with alcohol reflux 3-5 time, merge extractive liquid, concentrates and obtains fluid extract.

The extracting method of described Herba Lycopi extract, Poria extract, Radix Scutellariae extract, Rhizoma Kaempferiae extract is: clean, and chopping, using water as solvent, uses ultrasonic extraction 3-6h, concentrates and obtain fluid extract after filtering.

The extracting method of described Cortex Eucommiae extract, Semen Vaccariae extract, Semen Astragali Complanati extract, Semen Torreyae extract is: clean, and Testa Tritici fries 0.5-1h, and temperature is 120-130 DEG C, Testa Tritici is filtered after cooling, using ethanol as solvent, use ultrasonic extraction 3-6h, concentrate after filtering and obtain fluid extract.

Described Radix Glycyrrhizae extract, orange blossom extract, Cananga odorata extract, Aloe extract are obtained by supercritical carbon dioxide extraction, and extraction temperature is 30-35 DEG C, and extracting pressure is 18-25MPa, and resolution temperature is 42-53 DEG C, and parsing pressure is 5-7MPa.

Prescription A is by mannitol, oligopeptide-1, oligopeptide-3, Cortex Magnoliae Officinalis extract, Rhizoma Gastrodiae extract, Horse chest Nut P.E, Radix Curcumae extract, Rhizoma Sparganii extract, Radix Berberidis extract, Radix Asteris extract, Fructus Sophorae extract, Radix Angelicae Sinensis extract mix homogeneously, then use freezer dryer to be frozen into solid, then vacuum drying obtain.

Water, Sensiva SC50, hyaluronate sodium, yeast fermentation lysate filtrate, Herba Lycopi extract, Poria extract, Radix Scutellariae extract, Rhizoma Kaempferiae extract, Cortex Phellodendri extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract, Cortex Eucommiae extract, Semen Vaccariae extract, Semen Astragali Complanati extract, Semen Torreyae extract, Radix Glycyrrhizae extract, orange blossom extract, Cananga odorata extract, Aloe extract mix homogeneously obtain by prescription B.

A using method for the medicine of above-mentioned treatment pox hole and depressed scar, by described solids and liquid object with weight ratio 1:(50-75) directly smear to desired area after mix homogeneously.

Hereinafter, by embodiment, the present invention is explained in more detail, but should be understood that these embodiments are only illustrative and nonrestrictive.If do not have other to illustrate, raw materials used is all commercially available.

The present invention is described in detail referring to several example.

Embodiment 1

Treat a medicine for pox hole and depressed scar, be made up of prescription A and prescription B,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 15 parts, oligopeptide-18 parts, oligopeptide-38 parts, Cortex Magnoliae Officinalis extract 12 parts, Rhizoma Gastrodiae extract 10 parts, Horse chest Nut P.E 28 parts, Radix Curcumae extract 16 parts, Rhizoma Sparganii extract 8 parts, Radix Berberidis extract 36 parts, Radix Asteris extract 16 parts, Fructus Sophorae extract 10 parts, Radix Angelicae Sinensis extract 6 parts;

Prescription A uses freezer dryer to be frozen into solid by after above-mentioned substance mix homogeneously, then vacuum drying obtains.

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 50 parts, hyaluronate sodium 20 parts, yeast fermentation lysate filtrate 36 parts, Herba Lycopi extract 18 parts, Poria extract 8 parts, Radix Scutellariae extract 8 parts, Rhizoma Kaempferiae extract 24 parts, Cortex Phellodendri extract 12 parts, Radix Morindae Officinalis extract 8 parts, Radix Gentianae Macrophyllae extract 8 parts, Cortex Eucommiae extract 36 parts, Semen Vaccariae extract 18 parts, Semen Astragali Complanati extract 32 parts, Semen Torreyae extract 12 parts, Radix Glycyrrhizae extract 22 parts, orange blossom extract 6 parts, Cananga odorata extract 6 parts, Aloe extract 6 parts.

Prescription B is obtained by above-mentioned substance mix homogeneously.

The extracting method of described Cortex Magnoliae Officinalis extract, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, Radix Berberidis extract is: clean, chopping, and by acetic acid reflux, extract, 5 times, merge extractive liquid, vacuum drying, to obtain final product.

The extracting method of described Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, Radix Angelicae Sinensis extract is: clean, chopping, and refined honey mixing post-heating to 50 DEG C, insulation 4h, using water as solvent after cooling, uses ultrasonic extraction 5h, vacuum drying extracting solution, to obtain final product.

The extracting method of described Cortex Phellodendri extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract is: clean, chopping, with alcohol reflux 5 times, merge extractive liquid, concentratedly obtains fluid extract.

The extracting method of described Herba Lycopi extract, Poria extract, Radix Scutellariae extract, Rhizoma Kaempferiae extract is: clean, and chopping, using water as solvent, uses ultrasonic extraction 5h, concentrates and obtain fluid extract after filtering.

The extracting method of described Cortex Eucommiae extract, Semen Vaccariae extract, Semen Astragali Complanati extract, Semen Torreyae extract is: clean, and Testa Tritici fries 40min, and temperature is 125 DEG C, Testa Tritici is filtered after cooling, using ethanol as solvent, use ultrasonic extraction 5h, concentrate after filtering and obtain fluid extract.

Described Radix Glycyrrhizae extract, orange blossom extract, Cananga odorata extract, Aloe extract are obtained by supercritical carbon dioxide extraction, and extraction temperature is 33 DEG C, and extracting pressure is 22MPa, and resolution temperature is 45 DEG C, and parsing pressure is 6MPa.

Embodiment 2

Identical with embodiment 1, difference is,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 13 parts, oligopeptide-16 parts, oligopeptide-36 parts, Cortex Magnoliae Officinalis extract 10 parts, Rhizoma Gastrodiae extract 8 parts, Horse chest Nut P.E 26 parts, Radix Curcumae extract 14 parts, Rhizoma Sparganii extract 6 parts, Radix Berberidis extract 34 parts, Radix Asteris extract 14 parts, Fructus Sophorae extract 8 parts, Radix Angelicae Sinensis extract 6 parts;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 40 parts, hyaluronate sodium 16 parts, yeast fermentation lysate filtrate 32 parts, Herba Lycopi extract 16 parts, Poria extract 6 parts, Radix Scutellariae extract 6 parts, Rhizoma Kaempferiae extract 22 parts, Cortex Phellodendri extract 10 parts, Radix Morindae Officinalis extract 6 parts, Radix Gentianae Macrophyllae extract 6 parts, Cortex Eucommiae extract 34 parts, Semen Vaccariae extract 16 parts, Semen Astragali Complanati extract 30 parts, Semen Torreyae extract 10 parts, Radix Glycyrrhizae extract 20 parts, orange blossom extract 4 parts, Cananga odorata extract 4 parts, Aloe extract 4 parts.

Embodiment 3

Identical with embodiment 1, difference is,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 11 parts, oligopeptide-14 parts, oligopeptide-34 parts, Cortex Magnoliae Officinalis extract 8 parts, Rhizoma Gastrodiae extract 6 parts, Horse chest Nut P.E 24 parts, Radix Curcumae extract 12 parts, Rhizoma Sparganii extract 4 parts, Radix Berberidis extract 32 parts, Radix Asteris extract 12 parts, Fructus Sophorae extract 6 parts, Radix Angelicae Sinensis extract 4 parts;

Prescription B is liquid form, and its material composition and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 35 parts, hyaluronate sodium 14 parts, yeast fermentation lysate filtrate 28 parts, Herba Lycopi extract 14 parts, Poria extract 4 parts, Radix Scutellariae extract 4 parts, Rhizoma Kaempferiae extract 20 parts, Cortex Phellodendri extract 8 parts, Radix Morindae Officinalis extract 4 parts, Radix Gentianae Macrophyllae extract 4 parts, Cortex Eucommiae extract 32 parts, Semen Vaccariae extract 14 parts, Semen Astragali Complanati extract 28 parts, Semen Torreyae extract 8 parts, Radix Glycyrrhizae extract 18 parts, orange blossom extract 2 parts, Cananga odorata extract 2 parts, Aloe extract 2 parts.

Embodiment 4

Identical with embodiment 1, difference is,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 17 parts, oligopeptide-110 parts, oligopeptide-310 parts, Cortex Magnoliae Officinalis extract 14 parts, Rhizoma Gastrodiae extract 12 parts, Horse chest Nut P.E 30 parts, Radix Curcumae extract 18 parts, Rhizoma Sparganii extract 10 parts, Radix Berberidis extract 38 parts, Radix Asteris extract 18 parts, Fructus Sophorae extract 12 parts, Radix Angelicae Sinensis extract 10 parts;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 60 parts, hyaluronate sodium 24 parts, yeast fermentation lysate filtrate 40 parts, Herba Lycopi extract 20 parts, Poria extract 10 parts, Radix Scutellariae extract 10 parts, Rhizoma Kaempferiae extract 26 parts, Cortex Phellodendri extract 14 parts, Radix Morindae Officinalis extract 10 parts, Radix Gentianae Macrophyllae extract 10 parts, Cortex Eucommiae extract 38 parts, Semen Vaccariae extract 20 parts, Semen Astragali Complanati extract 34 parts, Semen Torreyae extract 14 parts, Radix Glycyrrhizae extract 24 parts, orange blossom extract 8 parts, Cananga odorata extract 8 parts, Aloe extract 8 parts.

Embodiment 5

Identical with embodiment 1, difference is,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 19 parts, oligopeptide-112 parts, oligopeptide-312 parts, Cortex Magnoliae Officinalis extract 16 parts, Rhizoma Gastrodiae extract 14 parts, Horse chest Nut P.E 32 parts, Radix Curcumae extract 20 parts, Rhizoma Sparganii extract 12 parts, Radix Berberidis extract 40 parts, Radix Asteris extract 20 parts, Fructus Sophorae extract 14 parts, Radix Angelicae Sinensis extract 12 parts;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 65 parts, hyaluronate sodium 26 parts, yeast fermentation lysate filtrate 44 parts, Herba Lycopi extract 22 parts, Poria extract 12 parts, Radix Scutellariae extract 12 parts, Rhizoma Kaempferiae extract 28 parts, Cortex Phellodendri extract 16 parts, Radix Morindae Officinalis extract 12 parts, Radix Gentianae Macrophyllae extract 12 parts, Cortex Eucommiae extract 40 parts, Semen Vaccariae extract 22 parts, Semen Astragali Complanati extract 36 parts, Semen Torreyae extract 16 parts, Radix Glycyrrhizae extract 26 parts, orange blossom extract 10 parts, Cananga odorata extract 10 parts, Aloe extract 10 parts.

Comparative example 1

Identical with embodiment 1, difference is that the material composition of prescription A is not containing Radix Berberidis extract.

Comparative example 2

Identical with embodiment 1, difference is that the material composition of prescription A is not containing Horse chest Nut P.E.

Comparative example 3

Identical with embodiment 1, difference is that the material composition of prescription B is not containing Semen Astragali Complanati extract.

Comparative example 4

Identical with embodiment 1, difference is that the material composition of prescription B is not containing Cortex Eucommiae extract.

Comparative example 5

Identical with embodiment 1, difference is that the material composition of prescription A is not containing Radix Asteris extract.

Comparative example 6

Identical with embodiment 1, difference is that the material composition of prescription B is not containing Rhizoma Kaempferiae extract.

Comparative example 7

Identical with embodiment 1, difference is that the material composition of prescription A is not containing Cortex Magnoliae Officinalis extract.

Comparative example 8

Identical with embodiment 1, difference is, the extracting method of Radix Berberidis extract is: using water as solvent, use ultrasonic extraction 5h, concentrates and obtain fluid extract after filtering.

Comparative example 9

Identical with embodiment 1, difference is, the extracting method of Horse chest Nut P.E is: clean, chopping, with alcohol reflux 5 times, merge extractive liquid, concentratedly obtains fluid extract.

Comparative example 10

Identical with embodiment 1, difference is, the extracting method of Semen Astragali Complanati extract is: clean, chopping, with alcohol reflux 5 times, merge extractive liquid, concentratedly obtains fluid extract.

Comparative example 11

Identical with embodiment 1, difference is, the extracting method of Cortex Eucommiae extract is: clean, chopping, with alcohol reflux 5 times, merge extractive liquid, concentratedly obtains fluid extract.

Evaluation methodology

Select 160 volunteers, male 16 people of age between 18-25 year, women 16 people; Male 16 people of age between 26-30 year, women 16 people; Male 16 people of age between 31-35 year, women 16 people; Male 16 people of age between 36-40 year, women 16 people; Male 16 people of age between 41-45 year, women 16 people.Volunteer's face of selecting all has pox to cheat or depressed scar, and in previous month of test, do not use the product of any treatment pox hole or depressed scar.Be 1-16 group by 160 volunteer's lacings, often organize 10 people, men and women each 1 people of age between 18-25 year, men and women each 1 people of age between 26-30 year, men and women each 1 people of age between 31-35 year, men and women each 1 people of age between 36-40 year, men and women each 1 people of age between 41-45 year.

1-5 group uses embodiment 1-5 respectively, and 6-16 group uses comparative example 1-11 respectively, and morning, noon and afternoon every day respectively use once, gets prescription A16mg during use, prescription B1g, directly spreads upon on pox hole and depressed scar after mix homogeneously, continuously uninterrupted use 180 days.

Opinion rating is divided into A, and pox hole and depressed scar disappear completely; B, pox hole and depressed scar alleviate about 80%; C, pox hole and depressed scar alleviate about 30%; D, pox hole and depressed scar do not change.

Therapeutic outcome sees the following form.

Group	A	B	C	D
					1st group	9	1	0	0
2nd group	7	2	1	0
					3rd group	8	1	1	0
4th group	8	2	0	0
					5th group	7	1	2	0
6th group	0	2	4	4
					7th group	0	3	4	3
8th group	0	2	3	5
					9th group	0	2	4	4
10th group	5	3	2	0
					11st group	4	3	3	0
12nd group	5	3	2	0
					13rd group	2	4	3	1
14th group	1	3	4	2
					15th group	0	4	2	4
16th group	0	3	5	2

As can be seen from test result, a kind of medicine for the treatment of pox hole and depressed scar provided by the invention can promote defective tissue cell regeneration, is conducive to the growth of skin depressions place cell.Effective improve 18-45 year the pox hole of people of each age level and depressed scar, simultaneously containing hormone, environmental protection, provides useful effect.

The above, be only preferred embodiment of the present invention, be not intended to limit protection scope of the present invention.Every equalization done according to content of the present invention changes and modifies, and is all encompassed in the scope of the claims of the present invention.

Claims (10)

1. treat a medicine for pox hole and depressed scar, it is characterized in that, be made up of prescription A and prescription B,

Prescription A is solid forms, and its material composition and the parts by weight of each material in this prescription are:

Mannitol 11-19 part, oligopeptide-14-12 part, oligopeptide-34-12 part, Cortex Magnoliae Officinalis extract 8-16 part, Rhizoma Gastrodiae extract 6-14 part, Horse chest Nut P.E 24-32 part, Radix Curcumae extract 12-20 part, Rhizoma Sparganii extract 4-12 part, Radix Berberidis extract 32-40 part, Radix Asteris extract 12-20 part, Fructus Sophorae extract 6-14 part, Radix Angelicae Sinensis extract 4-12 part;

Prescription B is liquid form, and its material composition and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 35-65 part, hyaluronate sodium 14-26 part, yeast fermentation lysate filtrate 28-44 part, Herba Lycopi extract 14-22 part, Poria extract 4-12 part, Radix Scutellariae extract 4-12 part, Rhizoma Kaempferiae extract 20-28 part, Cortex Phellodendri extract 8-16 part, Radix Morindae Officinalis extract 4-12 part, Radix Gentianae Macrophyllae extract 4-12 part, Cortex Eucommiae extract 32-40 part, Semen Vaccariae extract 14-22 part, Semen Astragali Complanati extract 28-36 part, Semen Torreyae extract 8-16 part, Radix Glycyrrhizae extract 18-26 part, orange blossom extract 2-10 part, Cananga odorata extract 2-10 part, Aloe extract 2-10 part.

2. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, is characterized in that,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 13-17 part, oligopeptide-16-10 part, oligopeptide-36-10 part, Cortex Magnoliae Officinalis extract 10-14 part, Rhizoma Gastrodiae extract 8-12 part, Horse chest Nut P.E 26-30 part, Radix Curcumae extract 14-18 part, Rhizoma Sparganii extract 6-10 part, Radix Berberidis extract 34-38 part, Radix Asteris extract 14-18 part, Fructus Sophorae extract 8-12 part, Radix Angelicae Sinensis extract 6-10 part;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 40-60 part, hyaluronate sodium 16-24 part, yeast fermentation lysate filtrate 32-40 part, Herba Lycopi extract 16-20 part, Poria extract 6-10 part, Radix Scutellariae extract 6-10 part, Rhizoma Kaempferiae extract 22-26 part, Cortex Phellodendri extract 10-14 part, Radix Morindae Officinalis extract 6-10 part, Radix Gentianae Macrophyllae extract 6-10 part, Cortex Eucommiae extract 34-38 part, Semen Vaccariae extract 16-20 part, Semen Astragali Complanati extract 30-34 part, Semen Torreyae extract 10-14 part, Radix Glycyrrhizae extract 20-24 part, orange blossom extract 4-8 part, Cananga odorata extract 4-8 part, Aloe extract 4-8 part.

3. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, is characterized in that,

The material composition of prescription A and the parts by weight of each material in this prescription are:

Mannitol 15 parts, oligopeptide-18 parts, oligopeptide-38 parts, Cortex Magnoliae Officinalis extract 12 parts, Rhizoma Gastrodiae extract 10 parts, Horse chest Nut P.E 28 parts, Radix Curcumae extract 16 parts, Rhizoma Sparganii extract 8 parts, Radix Berberidis extract 36 parts, Radix Asteris extract 16 parts, Fructus Sophorae extract 10 parts, Radix Angelicae Sinensis extract 6 parts;

The material composition of prescription B and the parts by weight of each material in this prescription are:

100 parts, water, Sensiva SC50 50 parts, hyaluronate sodium 20 parts, yeast fermentation lysate filtrate 36 parts, Herba Lycopi extract 18 parts, Poria extract 8 parts, Radix Scutellariae extract 8 parts, Rhizoma Kaempferiae extract 24 parts, Cortex Phellodendri extract 12 parts, Radix Morindae Officinalis extract 8 parts, Radix Gentianae Macrophyllae extract 8 parts, Cortex Eucommiae extract 36 parts, Semen Vaccariae extract 18 parts, Semen Astragali Complanati extract 32 parts, Semen Torreyae extract 12 parts, Radix Glycyrrhizae extract 22 parts, orange blossom extract 6 parts, Cananga odorata extract 6 parts, Aloe extract 6 parts.

4. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, it is characterized in that, the extracting method of described Cortex Magnoliae Officinalis extract, Rhizoma Gastrodiae extract, Radix Curcumae extract, Rhizoma Sparganii extract, Radix Berberidis extract is: clean, chopping, by acetic acid reflux, extract, 3-5 time, merge extractive liquid, vacuum drying, to obtain final product.

5. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, it is characterized in that, the extracting method of described Horse chest Nut P.E, Radix Asteris extract, Fructus Sophorae extract, Radix Angelicae Sinensis extract is: clean, chopping, and refined honey mixing post-heating is to 45-65 DEG C, insulation 3-5h, using water as solvent after cooling, use ultrasonic extraction 3-6h, filter final vacuum dry, to obtain final product.

6. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, it is characterized in that, the extracting method of described Cortex Phellodendri extract, Radix Morindae Officinalis extract, Radix Gentianae Macrophyllae extract is: clean, chopping, with alcohol reflux 3-5 time, merge extractive liquid, concentratedly obtain fluid extract.

7. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, it is characterized in that, the extracting method of described Herba Lycopi extract, Poria extract, Radix Scutellariae extract, Rhizoma Kaempferiae extract is: clean, chopping, using water as solvent, use ultrasonic extraction 3-6h, concentrate after filtering and obtain fluid extract.

8. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, it is characterized in that, the extracting method of described Cortex Eucommiae extract, Semen Vaccariae extract, Semen Astragali Complanati extract, Semen Torreyae extract is: clean, Testa Tritici fries 0.5-1h, and temperature is 120-130 DEG C, filters Testa Tritici after cooling, chopping, using ethanol as solvent, use ultrasonic extraction 3-6h, concentrate after filtering and obtain fluid extract.

9. the medicine for the treatment of pox hole as claimed in claim 1 and depressed scar, it is characterized in that, described Radix Glycyrrhizae extract, orange blossom extract, Cananga odorata extract, Aloe extract are obtained by supercritical carbon dioxide extraction, extraction temperature is 30-35 DEG C, extracting pressure is 18-25MPa, resolution temperature is 42-53 DEG C, and parsing pressure is 5-7MPa.

10. the using method of medicine of a treatment pox hole any one of claim 1-9 as described in claim and depressed scar, it is characterized in that, by described solids and liquid object with weight ratio 1:(50-75) directly smear to desired area after mix homogeneously.