CN104771601B - A kind of combination agent for improving blood viscosity and hematoblastic aggregation - Google Patents

Abstract

The invention discloses a kind of combination agents for improving blood viscosity and hematoblastic aggregation, belong to technical field of traditional Chinese medicine preparation, bulk pharmaceutical chemicals weight proportion：10 25 parts of propolis, 5 15 parts of earth-worm extractive as raw material, 10 18 parts of radix-polygoni multiflori extract, 10 15 parts of haw thorn extract, 10 15 parts of cassia seed extract, 10 20 parts of wax gourd bark extract, 10 18 parts of Salvia root P.E, 10 18 parts of angelica extract, 10 22 parts of Rhizoma Gastrodiae extract, 15 25 parts of uncaria extract, 6 12 parts of safflower extract, 5 12 parts of hirudo extract, 12 20 parts of Astragalus Root P.E, 10 21 parts of dried orange peel extracts, 15 25 parts of Prunella vulgaris extract, 10 20 parts of cornel extractive, 10 15 parts of papaya extractives, 8 15 parts of smoked plum extractive, 8 15 parts of pomegranate rind extract；The present invention improves blood viscosity and hematoblastic aggregation, to the disease energy auxiliary treatment being affected by it.

Description

A kind of combination agent for improving blood viscosity and hematoblastic aggregation

Technical field

The invention discloses a kind of combination agents for improving blood viscosity and hematoblastic aggregation, belong to Chinese medicine preparation technology neck Domain, and in particular to improve the proportioning of blood viscosity and the combination agent of hematoblastic aggregation, the production method of combination agent.

Background technology

Blood is a kind of opaque thick liquid of the red flowed in the blood vessel and heart of people.Blood is by blood plasma and blood Cell forms, and haemocyte includes red blood cell and leucocyte and blood platelet three classes cell.

Blood viscosity is the abbreviation of blood viscosity, reflects viscosity of blood, caused by being slow blood flow and hemorheology Blood characteristics with the characteristics of abnormal parameters.Generally, precisely due to erythrocyte aggregation bunchiness in blood, loses due gap And crooked deformability of the red blood cell when passing through tiny capillaries declines in distance or blood, makes the viscosity of blood Increase, circulation resistance increase, caused by microcirculation blood flow is not smooth.And platelet aggregation generally refers to the mutual adhesion of blood platelet, Lose due gap and distance.

Clinically there are many diseases, such as artery sclerosis, cerebral thrombus, myocardial infarction, hypertension, diabetes, obstructive view Film is scorching and chronic liver and kidney disease etc. all with blood is thick and platelet aggregation close relation.It is blood first when disease occurs The certain compositions and function of liquid are changed, and common is exactly that blood viscosity and hematoblastic concentration class exception occur.Micro- See that the red blood cell periphery charge balance in blood is broken under mirror, bond occur when serious around a phenomenon.Lead to blood Flows decrease, the oxygen and nutriment that body tissue is obtained are greatly decreased, the aging of particularly excessive red blood cell, hard Change, red cell conglomeration occurs, exacerbation blood is thick and blood coagulation occurs, and blood coagulation block occurs, causes blood vessel embolism, so as to cause ischemic The generation of the diseases such as the property heart, the cerebrovascular.And there is exception and not only cause disease in blood viscosity and hematoblastic concentration class, also result in Drug is difficult to be absorbed by organisms during treatment.

The present invention provides a kind of combination agent for improving blood viscosity and hematoblastic aggregation, is raw material with traditional Chinese medicine, Quick repair can be generated to abnormal blood viscosity, platelet aggregation.In clinical process, blood viscosity and blood are relieved After the high aggregation of platelet, because the therapeutic effect of disease such as diabetes, cancer etc. influenced by its symptom is also very notable, this hair Bright prescription agent can be processed into required dosage form, be used convenient for patient.

Invention content

The present invention according to the research of modern Chinese herbal medicine active ingredient and traditional tcm theory, provide a kind of improvement blood viscosity and The combination agent of hematoblastic aggregation, the effective elements of the medicine is prepared in direct use, and therapeutic effect is quick and notable.Specific application Raw material Chinese medicine it is as follows：

Mandarin orange【Nature and flavor】It is sweet acid, cool.1. Cui Yu tin《Cuisine canon》:" acid sweet in flavor, it is small cold, it is nontoxic."②《Kaibao Bencao》:" it is sweet in flavor, Great Cold."③《Daily book on Chinese herbal medicine》:" acid sweet in flavor is put down, nontoxic."【Major function】It promotes the production of body fluid to quench thirst, diuresis of sobering up.1. Cui Yu tin《Food Through》:" gas under food, the main hot dysphoria of chest."②《Kaibao Bencao》:" heat toxin in sharp stomach, only sudden and violent thirsty, diuresis."③《Medical center is compiled It will》:" relieving restlessness is sobered up."【Chemical analysis】Containing stigmasterol, cupreol and xanthyletin etc. in mandarin orange.Mandarin orange fruit contains orange peel Glucoside, Nobiletin and volatile oil etc..

Apple【Nature and flavor】It is sweet, it is cool.【Major function】It promotes the production of body fluid, moistening lung, relieving restlessness solves administration, and appetizing is sobered up.①《A thousand pieces of gold is eaten It controls》：" invigorating heart gas." 2. Meng's numerous：" main bowl spares coke various symptims and signs of deficiency gas and spleen；Gas is obstructed after soldier suffers from food, and life smashes juice and takes it."③《Drink meals Just》；It " slakes thirst and help produce saliva."④《Yunnan Pu's book on Chinese herbal medicine》：" stew promoting the production of body fluid for cream food."⑤《This sketch of the southern regions of the Yunnan Province is said》：" spleen deficiency fire Sheng is controlled, is mended Middle QI invigorating.Arthralgia and myalgia is controlled with food and drink.Putting sore blush on the skin can dissipate."⑥《Medical center bun will》：" quench the thirst, relieving restlessness, relieving summer-heat, stasis eliminatings."⑦ 《Diet spectrum is occupied with breath》：" heart is pleased in moistening lung, and appetizing of promoting the production of body fluid is sobered up."【Chemical analysis】Apple is mainly containing carbohydrate, wherein big portion It is sugar to divide, sucrose about 4% different with kind, reduced sugar 6~9%.It is not starch-containing into hot fruit, disappear with the maturation of fruit It loses.Containing acid about 0.5%, predominantly malic acid, in addition still containing quininic acid, citric acid, tartaric acid.Alcohols contains in fragrance ingredient 92%, carbonyl class compound 6% still has ester and acid in addition.

Grape【Nature and flavor】Sweet acid is put down.【Channel tropism】Enter lung, spleen, kidney channel.①《It obtains with book on Chinese herbal medicine》：" enter meridian of Hand-TAI YANG."②《This Grass is looked for the truth》：" enter kidney."③《Book on Chinese herbal medicine is new again》：" enter spleen, lung two passes through."【Major function】It fills blood, strengthening the bones and muscles, diuresis.Control gas The deficiency of blood is weak, cough due to deficiency of the lung, palpitation and night sweat, Bi condition, gonorrhoea, edema.①《This warp》：" main reinforcement bone arthritis with fixed pain caused by dampness, QI invigorating times power, by force Will makes us fertile and is good for resistance to famine, bears chill.It can make wine."②《It does not record》：" it relieves oedema or abdominal distension through diuresis or purgation, diuresis."③《Haigoushen》：" aqueous vapor between intestines is removed, Leaching, diuresis are controlled in tune."④《Bencao Tujing》：" gas hair sore rash does not go out person when controlling, and grinds beverage."⑤《The southern regions of the Yunnan Province book on Chinese herbal medicine》：It is " big to mend Qi and blood, relaxing tendons and activating collaterals steep in wine and take it.It controls negative and positive and takes off disease, and control night sweat asthenic symptoms.Juice controls cough."⑥《This sketch of the southern regions of the Yunnan Province is said》：" Control variola poison, tire adverse QI rushing upwards, decoction drink be under."⑦《Hundred careless mirrors》：" control the wet pain of muscles and bones.Li Shui is very prompt, except edema all over." ⑧《This ear is new again》：" warm stomach invigorating the spleen controls the deficiency syndrome of the lung and trembles with fear and coughs, blood-breaking product subcutaneous ulcer knurl."⑨《Diet spectrum is occupied with breath》：" tonifying Qi, nourshing kidney liquid, Beneficial liver-yin, strengthening the bones and muscles are quenched the thirst, tocolysis."⑩《Xinjiang medicinal material》：" removing toxic substances dissipates table."《Luchuan book on Chinese herbal medicine》：" nourishing is strong, enriches blood, Cardiac stimulant diuresis.Pain in the back is controlled, is had a stomachache, neurolysis, deficiency of blood heartbeat."【Chemical analysis】Grape containing glucose, fructose, a small amount of sucrose, Xylose, tartaric acid, oxalic acid, citric acid, malic acid.Single glycoside containing various anthocyanidin and double glycosides again.Every 100 grams Containing 0.2 gram of protein, 4 milligrams of calcium, 15 milligrams of phosphorus, 0.6 milligram of iron, 0.04 milligram of carrotene, 0.04 milligram of thiamine, core yellow 0.01 milligram of element, 0.1 milligram of niacin, 4 milligrams of vitamin C.Grape Skin is containing Cyanidin, peonidin, delphinidin, petunia Element, malvidin, malvidin -3- β-glycoside.Seed oil content 9.58%.Catechol containing coke, nutgall catechu again Essence, gallate etc..

Sugarcane【Nature and flavor】It is sweet, it trembles with fear.【Channel tropism】Enter lung, stomach.【Major function】Disappear heat, promotes the production of body fluid, and lower gas is moisturized.Control pyreticosis Tianjin is hindered, restlessness and thirst, gastric disorder causing nausea vomiting, xeropulmonary cough, dry feces.And relieving alcoholism.①《It does not record》：" main lower gas helps spleen in Stomach, profit large intestine."②《Dietetic materia medica》：" main tonifying Qi, simultaneous lower gas."③《Japan hanako materia medica》：" sharp intestine and small intestine, lower diarrhea due to disorder of qi, tonifying spleen, Dissolving phlegm is quenched the thirst, except vexed heat."④《Daily book on Chinese herbal medicine》：" only abnormal heat polydipsia, relieving alcoholism."⑤《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" the hundred all sores of poison are controlled, Ulcer carbuncle on the back, mashes and applies it；Juice：Ill at ease and full of dread, deeply perturbed, apoplectic aphasia is controlled, is washed open underwater.Treacle food and stomach are endured again more It is good."⑥《This sketch of the southern regions of the Yunnan Province is said》：It " is taken with ginger juice, fugutoxin can be solved."⑦《Book on Chinese herbal medicine is new again》：It " relieves inflammation or internal heat in and, soothing the liver invigorating the spleen is raw Tianjin is quenched the thirst, and controls vomiting and diarrhoea, malaria, dysentery, all poison of solution sore fire."⑧《Diet spectrum is occupied with breath》：" throat, strengthening the bones and muscles, ceases wind blood-nourishing are big to mend Spleen is cloudy."

【Chemical analysis】In every lOO grams of edible part, 84 grams of moisture content, 0.2 gram of protein, fatty 0.5 gram, carbon hydrate 12 grams of object, 8 milligrams of calcium, 4 milligrams of phosphorus, 1.3 milligrams of iron.Containing a variety of amino acid in sugarcane juice, there are asparagine, asparatate, paddy Propylhomoserin, serine, alanine, valine, leucine, nor-leucine, lysine, alpha-amino-beta-hydroxybutyric acid, glutamine, proline, junket Propylhomoserin, cystine and phenylalanine, γ-aminobutyric acid etc..Also containing mesaconic acid, fumaric acid, succinic acid, aconitic acid, The organic acids such as Glycolic acid, malic acid, citric acid and oxalic acid.Also containing vitamin B6 in stipes, with content in the tender stem section on top compared with It is more.Also contain vitamin C in stem.Squeezing is gone in the bagasse of juice, contains polysaccharide；Sugarcane top is containing vitamin C, aconitic acid etc..Leaf wax In, in addition to cupreol, stigmasterol, campesterol, also containing 4 alpha-methyl-2 4- methylene-γ-cholestenol and citrostadienol.

Propolis【Nature and flavor】Taste micro-sweet；It is mild-natured.【Channel tropism】Liver；The spleen channel.【Major function】Moisturizing myogenic；Anti-inflammatory analgetic.Main stomach Ulcer；Canker sore；Cervical erosion；Herpes zoster；Ox-hide is considered to be worth doing；Psoriasis；Skin Tearing Pain；Corn；Burn and scald.【Chemical analysis】 The resinous about 50%-60% of propolis, the fragrant field trashes such as volatile oil 10% and some pollen of beeswax 30%.Mainly have flavonoids, phenols, Lactone, Coumarins, aldehyde, ketone, steroid, also containing vitamin B1, niacin, provitamin A and a variety of amino acid, sugar, 34 kinds of polysaccharide etc. and indispensable element：Oxygen, carbon, hydrogen, calcium, phosphorus, nitrogen, potassium, sulphur, sodium, chlorine, magnesium, iron, cobalt, copper, molybdenum, fluorine, aluminium, tin, Silicon, arsenic, selenium, titanium, vanadium, chromium, nickel, barium, zirconium, antimony, cadmium, silver, lead, strontium etc..

Earthworm【Nature and flavor】Cold, taste is salty.【Channel tropism】Liver, stomach, lung, bladder warp【Major function】Heat-clearing, soothing the liver, Zhichuan, dredging collateral. The flat liver of heat-clearing, relieving convulsion and spasm, relieving asthma, diuresis, dredging collateral eliminating impediment.Cure mainly high fever agitation, twitch, dyspnea and cough due to lung-heat, thermojunction renal shutdown, The cards such as numbness pain limb fiber crops, hemiplegia and sore swollen toxin.Cure mainly high fanatical dry, convulsion, headache due to pathogenic wind-heat, hot eyes, half body are not Then etc..Earthworm provide take liquid play the role of it is good determine cloperastine breathe heavily.Earthworm ash knits baldness with attar of rose hybrid energy.

【Chemical analysis】Earthworm Lumbrifebrine containing lumbrifebrine, lumbricin Lumbritin, terrestro-lumbrolysin Terrestro-lumbrolysin wide dragons Hypoxanthine containing hypoxanthine, succinic acid Succinic acid and L+ paddy The earthworms such as propylhomoserin also Xanthine containing xanthine, adenine Adenine, guanine Guanine, choline Choline, guanidine Guanidine is still containing a variety of amino acid, such as alanine, valine, leucine, phenylalanine, tyrosine, lysine.

Containing stearic acid, palmitic acid, highly unsaturated fatty acid, phosphorus in the lipid moieties of earthworm Lumbricus spencer Fat, cholesterine etc..Carbon containing aquation in the yellow cell tissue Chlorogogen tissue of earthworm Lumbricus terrestris It may be core yellow to close object, lipid, protein and basic amino acid contained by pigment to have its uranidin of histidine, arginine, lysine Plain Riboflavine or its similar substance.

The fleece-flower root【Nature and flavor】Bitter sweet is puckery, tepor.【Channel tropism】Enter liver and kidney channel.【Major function】Tonifying liver, kidney-nourishing, blood-nourishing are dispelled Wind.Liver-kidney Yin deficiency is controlled, hair must be early white, and the deficiency of blood is dizzy, and waist and knee is weak, and muscles and bones is ached, and passes out semen, collapses band, chronic malaria, protracted dysentery, Chronic Liver Inflammation, carbuncle swells, scrofula, intestines wind, haemorrhoids.RADIX POLYGONI MULTIFLORI PREPARATA filling liver kidney, benefiting essence-blood, black beard and hair strengthen the bone；It is early for dizziness and tinnitus, beard and hair In vain, soreness and weakness of waist and knees, extremity numbness, neurasthenia, hyperlipemia.①《The fleece-flower root is recorded》：" main five hemorrhoid, chronic ill cold air in waist abdomen are long Muscle strengthening the essence can be eaten, benefiting energy, long skin, macrobiosis."②《Japan hanako materia medica》：" control all cold air and intestines wind."③《Kai Baoben Grass》：" main scrofula, subduing inflammation, treat head wind sore, five hemorrhoid are only pained, beneficial vim and vigour, black moustache temples, please color, also control married woman's postpartum and All diseases under band." 4. Wang Haogu：" purging the liver of pathogenic fire wind."⑤《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" puckery essence, hard kidney qi, only red white turbid urine, reduces just, enters blood Point, dissolving phlegm poison.It controls and does leucoderma, sore scabies stubborn dermatitis, skin scabies ancient term for country school.Preventing malaria controls phlegm malaria."⑥《Drugization justice》：" beneficial liver, holds back blood, Enriching yin.Waist and knee weakness is controlled, muscles and bones is ached, and cuts empty malaria, and only kidney rushes down, and except uterine bleeding, ungirds down."⑦《Book on Chinese herbal medicine is stated》：" control apoplexy, head Bitterly, migratory arthralgia, the arthroncus of knee, epilepsy card, jaundice."⑧《Book on Chinese herbal medicine is new again》：" tonifying lung is empty, antiemetic blood." 9. Guangzhou army《Common Chinese herbal medicine Handbook》：" control neurasthenia, chronic hepatitis."⑩《Jiangxi herbal medicine》：" defaecation solves sore；Make ripe filling liver kidney, benefiting essence-blood."【Change Study part】Root and rhizome containing Anthraquinones, predominantly Chrysophanol and rheum emodin, be secondly Rhein, the Physcion of trace and Chrysophanic acid anthrone etc.（Without Rhein after toast）.In addition, starch-containing 45.2%, crude fat 3.1%, lecithin 3.7% etc..

Hawthorn【Nature and flavor】Sour sweet, tepor.【Channel tropism】Enter spleen, stomach, Liver Channel.【Major function】Digestion gathered food, scattered blood stasis drive silk ribbon Worm.Control meat product, abdominal mass, phlegm and retained fluid, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia postpartum postpartum abdominal pain, lochiorrhagia, children's breast food It stagnates.Food digesting stomach fortifying, scattered stasis.For meat stagnation, gastric ulcer fullness, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, trusted subordinate Shouting pain, hernia pain, hyperlipemia.1. Tao Hongjing：" liquor washes dermatitis rhus."②《Tang materia medica》：" juice takes main profit, hair washing and with Sore is itched."③《Bencao Tujing》：" control dysentery and Low Back Pain."④《Lv Cliff rocks book on Chinese herbal medicine》：It " can help digestion."⑤《Daily book on Chinese herbal medicine》：" helping digestion Product, row knot gas, the wide diaphragm of stomach invigorating, disappear blood mass at the right hypochondrium block."⑥《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" meat that disappears stagnates, lower gas；Control acid regurgitation, product block."⑦《This Grass covers bamboo fish trap》：" row knot gas, treats ruined hernia.It is " 8. peaceful former《Food mirror book on Chinese herbal medicine》：" change clot, air parcel, promoting blood circulation."⑨《Detailed outline》：" change diet, Disappear meat Ji , Disorder lumps in the abdomen, phlegm and retained fluid feeling of fullness acid regurgitation, and stagnant blood pain is swollen."⑩《Book on Chinese herbal medicine is new again》：" it is damp and hot to control spleen deficiency, help digestion mill product, sharp size Just."

【Chemical analysis】Fruit (epicatechin) containing left-handed epicatechin, Quercetin (quercetin), hyperin (hyperoside), chlorogenic acid (chlorogenicacid), citric acid (citricacid) and mono-methyl, dimethyl ester and front three Ester, sucrose, flavan polymers (flavanpolymers), also containing ursolic acid；Containing anthocyan (anthocyanin), acids can Dissolubility carbohydrate；Oxalic acid (oxalicacid), citric acid, malic acid (malicacid), amber cypress acid (succinicacid), pulp Middle aliphatic acid has：Linoleic acid, palmitic acid, stearic acid, oleic acid, leukotrienes.

Cassia seed【Nature and flavor】It is sweet, bitter, salty, it is slightly cold.【Channel tropism】Return liver, large intestine channel.【Major function】Heat-clearing improving eyesight, profit Intestines defaecation.For the puckery pain of hot eyes, the more tears of photophobia, dizziness of having a headache, mesh is secretly unknown, constipation.【Chemical analysis】Fresh seeds contain Chrysophanol, rheum emodin, aloe-emodin, Rhein, emodin monoglucoside, emodin anthrone, Physcion, obtusin, Aurantio-obtusin and rubrofusarin, Cassia pine, toralactone.Still contain vitamin A.

Waxgourd peel【Nature and flavor】It is sweet, it is cool.【Channel tropism】《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" enter spleen, lung two passes through."【Major function】Inducing diuresis for removing edema. It harnesses the river swollen, diarrhea, carbuncle swells.①《Bencao Tujing》：" function and wax gourd etc.."②《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" quench the thirst, dissolving phlegm is sharp small Just." " controls apoplexy."③《Detailed outline》：" main donkey horse sweat enters sore swells pain, dries in the shade for last paintings, and main injured damage is bitterly."④《Book on Chinese herbal medicine is again Newly》：" skin is walked, dries and chases after wind, tonifying spleen purging intense heat."⑤《Chongqing hall random notes》：" solution wind-heat, disappear edema."⑥《Classification herbal medicine Property》：" it harnesses the river swollen, hemorrhoid."⑦《Plant medicine state in Jiangsu》：" control diarrhea, back of foot edema."⑧《Shandong Chinese medicine》：" dampness removing is relieved summer heat."

【Chemical analysis】Waxgourd peel contains volatile ingredient：E-2- olefine aldehydrs（E-2-hexe-nal), just olefine aldehydr（n- Hexenal), formic acid hexanol ester（N-hexylformate), 2,5- dimethyl pyrazines（2,5-dimethylpyra-zine), 2,6- dimethyl pyrazines（2-ethyl-5-methylpyrazine)[1].Contain triterpene compound again：It is sour different to spend more Eremurus chinensis Enol ester（Isomultiflorenylacetate) [2], glut-5-en-3β-ol（Glutinol), simiarenol（Simiarenol), 5,24- cucurbit dienols（cucurbita-5,24-dienol)；Cholesterin derivative：24- this cholesteric -7,25- dienols （24-ethylcholesta-7,25-dienol), 24- base cholesterics -7,22, tri- enols of 25-（24-ethylcholesta-7, 22,25-trienol), 24- this cholest-7-enol（24-ethylcholesta-7-enol), 24- base cholesterics -7,22- Dienol（24-ethylchol-lesta-7,22-dienol).Separately contain vitamin（Vitamin) B1, B2, C, niacin （Niacin), carrotene（Carotene), glucose（Glucose), fructose（Fructose), sucrose（Srcrose), it is organic The inorganic elements such as acid, starch and sodium, potassium, calcium, iron, manganese, zinc.

Radix Salviae Miltiorrhizae【Nature and flavor】Hardship, tepor.【Channel tropism】Enter the heart, Liver Channel.【Major function】Promoting blood circulation, calming heart and tranquilizing mind, apocenosis, only Bitterly.Control angina pectoris, irregular menstruation, dysmenorrhoea, Amenorrhea, under metrorrhagia band, abdominal mass, accumulation, abdominal pain due to blood stasis, arthralgia, shock palpitation not sleep, Malignant sore swollen drug.①《This warp》：" main trusted subordinate's perverse trend, borborygmus is faint such as to leak water, fever and chills accumulation；Broken disease removes lump in the abdomen, only dysphoria, QI invigorating." ②《Wu Pu Bencao》：" control pain in the chest and abdomen."③《It does not record》：" trusted subordinate's chronic illness knot gas, stiff lumbar vertebra, foot numbness are gone in blood-nourishing；Exorcising stays heat, Long term usage profit people." 4. Tao Hongjing：" stain beverage it, treat wandering arthritis."⑤《Haigoushen》：" flaccidity of lower limbs is controlled, numbness is ached, is disliked in main；Control abdominal pain, gas Make sound toot shout."⑥《Japan hanako materia medica》：" sedate of reposing, tonneau Guan pulse.Control cold and hot labor, arthralgia, four limbs are unsuccessful；Apocenosis Analgesic, myogenic are put on flesh；Broken place blood, mends new green blood；Peaceful tire, falls stillborn foetus；Hemostasis is collapsed under band, adjusts married woman's passages through which vital energy circulates irregular, blood evil thought It is tired；Malignant sore mange, goitre are gone to live in the household of one's in-laws on getting married pyogenic infections, erysipelas；Headache, cute conjunctivitis, heat temperature are mad bored."⑦《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" bushing sedate is calmed the nerves peaceful The heart.Forgetful punching seized with terror is controlled, palpitation with fear is insomnia."⑧《Detailed outline》：" percardium is led in promoting blood circulation.Control colic."⑨《Yunnan Chinese herbal medicine choosing》：It is " living Blood dissipates the stasis of blood, sedation-analgesia.Control irregular menstruation, dysmenorrhoea, arthralgia pain due to rheumatism, uterine hemorrhage, haematemesis, mastitis, carbuncle swells."

【Chemical analysis】In liposoluble constituent, belong to quinone, ketone type structure has：Tanshinone（tanshinone)Ⅰ、ⅡA、ⅡB、 Vth, VI, Cryptotanshinone（Cryptotanshinone), isotanshinone（Isotanshinone) I, II, II B, different Cryptotanshinone （Isocryptotanshi-none), hydroxyl tanshinone（Hydroxytanshinone) II A, saivianic acid A acid （Methyltanshinonate), danshenxinkun（Dan-shexinkum) A, B, C, D, dihydroisotanshinone（dihydroi- Sotanshinone) I, new Cryptotanshinone（Neocryptotanshinone), the new Cryptotanshinone of hydroxyl is removed （Deoxyneocryptotanshinone), code name is 2- isopropyl -8- methylphenanthrene -3,4- diketone of Ro-090680（2- Isopropyl-8-methylphenanthrene-3,4-dione), remove first tanshinone（Nortanshinone), Radix Salviae Miltiorrhizae glycol （Tanshindiol) A, B, C, miltionone（miltirone）, 1- hydrogen miltionones（1-dehy-dromiltirone), 1- hydrogen Tanshinone（1-dehydrotanshinone) II A, 1- hydrogen are for different Cryptotanshinone（1-detoisocryptotanshinone), 3 Alpha-hydroxy tanshinone（3 α-hy-droxytanshinone) II A, 1,2- dihydro Radix Salviae Miltiorrhizae quinone（1,2-dihydrotan- Shinqiunone), aldehyde radical tanshinone（Formyltanshinenone), methylene dihydrotanshinone （Methylenedihydrotanshinone), 7 beta-hydroxy -8,13- abietadiene -11,12- diketone（7β-hydroxy-8- 13-abietadiene-11,12-dione), 1,2,5,6- tetrahydrochysene tanshinone（1,2,5,6- TeTCMLIBahydrotanshinone) I, 4- methylenes miltionone（4-methylenemiltirone), tanshinlactone （Tanshinlactone), dihydro tanshinlactone（Dihydrotanshinlactone), Radix Salviae Miltiorrhizae Spiroketals lactone（danshen- Spiroketallactone), table Radix Salviae Miltiorrhizae Spiroketals lactone（Epidanshenspiroketallac-tone), Radix Salviae Miltiorrhizae Spiroketals Lactone II is exactly the hidden spirolactone of Radix Salviae Miltiorrhizae（Cryptoac-etalide), sageone（miltiodiol)[22].Radix Salviae Miltiorrhizae cycloheptyl three Alkene phenolic ketone（miltipolone）Deng；Belong to having for other types structure：Salvia japonica oxide drops（Nor-salvioxide), more sieve Loose phenol（Ferruginol), carnosol（Salviol), cryptojaponol（Sugiol) etc..Water-soluble phenol acid compound has：It is red Ginseng acid（Sal-vianicacid) A, B, C, Salvianic acidA are also known as danshensu, structure D（+）-β-（3,4- dihydroxy phenyls）Breast Acid [D（+）-β-（3,4-dihydroxyphenyl) lacticacid], lithospermic acid B is the danshensu and 1 molecule by 3 molecules Caffeic acid（Caffeicacid) condensation is formed, and is exactly root of red-rooted salvia phenolic acid B；Radix Salviae Miltiorrhizae acid C is the condensation product of 2 molecule danshensus；Radix Salviae Miltiorrhizae Phenolic acid（salvianolicacid)A、B、C、D、E、G；Rosmarinic acid（Rosmarinicacid), methyl rosmarinate （Methylrosmarinate), alkannic acid mono methyl ester（Monomethyllithospermater), alkannic acid dimethyl ester （Dimethyllithospermate), alkannic acid ethyl ester（Ethylithospermate), alkannic acid （Lithospermicacid) B, protocatechualdehyde（Protocaterchualdehyde), caffeic acid, isoferulic acid （Isoferulicacid) etc..Also glucoside containing radix scutellariae（Baicalin), different imperatorin（Isomperatorin), ursolic acid （Ursolicacid), cupreol（β-stiosterol), Daucosterol（Daucosterol), 5-（3- hydroxypropyls）- 7- methoxies Base -2-（3- methoxyl group -4- hydroxyphenyls）- 3- benzofurans formaldehyde [5（3-hydroxypropyl)-7-methoxy-2-(3- Methoxy-4-hydroxyphe-nyl) -3-benzofurancarbaldehyde] [33], for by sapogenin（tigo- Genin) [1], stigmasterol（Stigmasterol) [7] etc..

Get salvia miltiorrhiza bge I II A, II B, Cryptotanshinone, danshenxinkun B, dihydrotanshinone Ⅰ, methylene Radix Salviae Miltiorrhizae quinone in rhizome.

Radix Angelicae Sinensis【Nature and flavor】Sweet, acrid, warm.【Channel tropism】Return liver, the heart, the spleen channel.【Major function】Replenishing and activating blood, menstruction regulating and pain relieving, profit Intestines defaecation.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism falls Flutter damage, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.【Chemical analysis】Root contains Volatile oil, Gansu Minxian County production person contain 0.7% containing 0.4%, Si Chuanwen counties production person.The main component of volatile oil has：Butylidenephthalide, The positive pentanone of adjacent carboxyl benzene and Δ 2,4- dihydro acid phthalic anhydrides.Volatile oil component is complicated, is singly that low boiling point part just has more than 10 kinds, wherein having A variety of hydro carbons, including 3 kinds of terpenes.Another sucrose containing volume（40%）, vitamin B12（0.25~40 microgram/100 gram）, vitamin A Class substance（It is 0.0675% containing rate in terms of vitamin A）.Containing palmitic acid, stearic acid, myristic acid and not in the saponification part of root Saturation oleic acid, sub- kojic acid；There is cupreol in not saponification ingredient.Herb has fragrance, it is known that each section is all containing volatile oil, and fruit Content is special more.

Rhizoma Gastrodiae【Nature and flavor】Sweet and neutral.【Channel tropism】Enter Liver Channel.【Major function】Ceases wind, arresting convulsion.Control dizziness pupil, head wind headache, Extremity numbness, hemiplegia, aphasia, infantile epilepsy and convulsions.①《This warp》：" main bad odor, long term usage benefiting energy, long cloudy fertilizer It is strong."②《It does not record》：" subduing inflammation, lower branch expire, hernia, lower blood."③《Haigoushen》：" the stupid numbness of cold air is controlled, paralysis is slow unsuccessful, and language is mostly all of a sudden Hu, more frightened mistake will."④《Japan hanako materia medica》：" aid yang qi, mends general debility, and promoting blood circulation is had one's ideas straightened out."⑤《Kaibao Bencao》：It is " main All rheumatism numbness, spasm of limbs, children's wind epilepsy, frightened gas, benifit waist and knees, strengthening tendons power." 6. Zhang Yuansu：" control wind void dizziness and headache."⑦ 《Collected statements on the herbal foundation》：" main intermittent headache, headache, dizzy empty rotation, the strong convulsion of epilepsy, four limbs contraction is anxious, and language has some setbacks, all apoplexy, wind phlegm."

【Chemical analysis】The higher main component of content is gastrodin in Rhizoma Gastrodiae（gasTCMLIBodin）, also referred to as Gastrodin, Its chemical composition is p- methylol benzene-β-D- glucopyanosides（p-hydroxymethylphenyl-β-D- glucopyranoside）；The another glucoside of ether containing Rhizoma Gastrodiae, chemical composition for pair-（4- acrinyls）Ether-mono--β-D- glucopyranoses Glucoside [bis- (4-hydroxybenzyl) ether-mono- β-D-glucoyranoside].It is right again containing p- hydroxyphenylmethyl alcohol Hydroxyphenylmethyl aldehyde（p-hydroxybenzaldehyde）, 4- acrinyl methyl ethers（4-hydroxybenzylmethylether）, 4- (4'- hydroxyls benzyloxy) methyl benzyl ether [4-（4'-hydroxybenzyloxy）- benzylmethylether], it is double（4- hydroxyl benzyls Base）Ether [bis (4-hydroxybenzyl) ether], three [4-（β-D- glucopyra glycosyloxies）Benzyl] citric acid ester.

Uncaria【Nature and flavor】It is sweet, it is cool.【Channel tropism】Enter liver, the heart channel of Hang-Shaoyin.【Major function】The flat liver of heat-clearing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Children are controlled to shy Xian Chi Zong, adult's slight Hypertension is dizzy, dizzy, married woman's eclampsia.①《It does not record》：" main children's fever and chills, frightened epilepsy."②《Pharmacological property By》：" main children's crying with fear , Chi Zong heat is stopped up."③《Japan hanako materia medica》：" control the disobedient tire wind of visitor."④《Detailed outline》：" big number of people rotation is dizzy, Suppressing liver-wind except heart heat, fishes abdominal pain in children, sends out macula."⑤《Book on Chinese herbal medicine sign will》：" relaxing muscles and tendons except dizzy, during lower gas is wide."⑥《Book on Chinese herbal medicine It states》：" paralysis due to windstroke, facial paralysis and all brothers' walking pain are controlled, podomere contraction is anxious.The paralysis of many years ago gout is controlled again, and tendon and vessel is arrested Suddenly have a pain endlessly."

【Chemical analysis】

The uncaria hook stem Alkaloid of oxindole containing 2-：Different wing handle uncaria is sour (isopteropodicacid), wing handle uncaria Sour (ptcropodicacid), cap spar acid (mi-traphyllicacid), indoles alkaloid：Tetrahydroalstonine (tetrahydroal-stonine), the i.e. different wing handle uncaria acid methyl esters of different wing handle rhynchophyllin (isopteropodine) (isopteropodicacidmethylester) isorhynchophylline.Wing handle rhynchophyllin (pteropo-dine) i.e. wing handle uncaria acid first Ester (pteropodicacidmethylester), isoformosanine (7-isorormosanine), mitragynine are cap spar acid Methyl esters (mitraphylline, mitraphyllicacidmethylester).Rhynchophyllin, isorhynchophylline N- oxides (isorhynchophyllineN-oxide), wing handle Rhynchophylline N-oxide (pteropodineN-oxide), rhynchophyllin N- oxygen Compound (rhynchophyllineN-oxide), mitragynine N- oxides (mitraphyllineN-oxide).Containing Anisodus luridus Plain (scopole-tin) 3. largeleaf gambirplant branchlet leaf oxindole alkaloids containing 2-：Isorhynchophylline, rhynchophyllin, ocrynoxine (corynoxine), ocrynoxine (corynoxine) B.

Safflower【Nature and flavor】It is acrid in flavour and warm in nature.【Channel tropism】Converge to heart and liver channels.【Major function】Invigorate blood circulation, removing blood stasis and analgesics.For Amenorrhea, Dysmenorrhoea, lochia, abdominal mass lump in the abdomen, injury from falling down, sore swell and ache curative.

【Chemical analysis】Safflower contains carthamin yellow and carthamin.Carthamin is hydrolyzed through hydrochloric acid, obtains glucose and carthamin. Also containing 15 α, 20 beta-dihydroxies-Δ 4- pregnene -3- ketone.Separately still it is fatty oil claim safflower oil, be palmitic acid, stearic acid, arachidic acid, The glyceride type of oleic acid, linoleic acid, leukotrienes etc..Leaf -7- containing cyanidenon glycosides.

Leech【Nature and flavor】Salty hardship is put down, toxic.【Channel tropism】Enter liver, bladder warp.【Major function】Blood-breaking, by the stasis of blood, promoting menstruation.It controls Blood is stored, abdominal mass, accumulation, women's Amenorrhea, dry blood is into consumptive disease, injury from falling down, mesh also pain, cloudiness.

【Chemical analysis】Leech contain 17 kinds of amino acid, wherein ammonia needed by human its acid 7 kinds, account for total amino acid content 39% with On.With glutamic acid（glutamicacid）, aspartic acid（aspartiacid）, leucine（leucine）, lysine （lysine）And valine（valine）Content is higher.Total amino acid content accounts for about more than 49% leech dry weight.In addition, leech Mainly containing protein, heparin（heparin）, antithrombase（antithrombin）, a kind of anti-freezing is contained in fresh leech saliva Blood substance name hirudin.（hirudin）In addition leech also contains macroelement sodium needed by human, potassium, calcium, magnesium etc., and content It is higher.Also contain totally 28 kinds of trace elements such as iron, manganese, zinc, silicon, aluminium.

Radix Astragali【Nature and flavor】It is sweet, tepor.【Channel tropism】Return lung, the spleen channel.【Major function】Invigorating qi for strengthening superficies, torr sore myogenic.Cure mainly body Empty spontaneous perspiration, chronic diarrhea, rectal prolapse, the prolapse of uterus, chronic nephritis, physically weak edema, chronic ulcer, the long disunion of the open sore part.

【Chemical analysis】Calycosin containing flavones ingredient（calycosin）, 3- hydroxyl -9,10- dimethoxy red sandalwoods Alkane, also containing astragalus saponin I, V, III（astragalosideⅠ、Ⅴ、Ⅲ）.

Dried orange peel【Nature and flavor】It is warm-natured, acrid flavour, bitter.【Channel tropism】Enter the spleen channel, stomach, lung channel.【Attending effectiveness】Regulating qi-flowing for strengthening spleen is adjusted In, eliminating dampness, resolving sputum.Cure mainly the abdominal fullness and distention of the taste stagnation of the circulation of vital energy or pain, indigestion.Abdominal distension uncomfortable in chest in wet turbid resistance, it is indigestion and loss of appetite just It is half congealed.The cough and asthma of phlegm obstructing lung.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.《Compendium of Materia Medica》：It is to hundred and always The work(of chess qi-regulating eliminating dampness is taken, is then mended with tonic, is then rushed down with cathartic, is then risen with hydrargyrum oxydatum crudum, is then dropped with medicine is dropped.Spleen is the mother of vigour, lung Be take the photograph gas will, therefore orange peel for two through qi leel will, but with match and reinforcing and reducing methods lift.②《Daily book on Chinese herbal medicine》：Can dissipate can rush down, energy Temperature can mend, and can disappear diaphragm gas, and resolving sputum saliva and spleen are only coughed, and lead to five leaching.③《Bencao Jingshu》：Pungent to dissipate, hardship can rush down, and temperature can pass through, then Under inverse gas, vomit and cough only, lump in the abdomen heat disappears in the heart, and spleen is dirty for sport mill object, and the stagnation of the circulation of vital energy cannot then digest trough, for spit inverse, cholera, The cards such as diarrhea, bitter temperature dried orange peel can dig the wet of spleen man, run stagnant gas, all card autotherapys.④《Collected statements on the herbal foundation》：Acrid flavour is apt to dissipate, therefore Gas can be opened；Stomach hardship, which is opened, lets out, therefore can manage it phlegm；Its temperature is put down, be good at it is sensible, therefore can preventing or arresting vomiting, cough-relieving, strengthening the spleen and stomach person.Dong Yuan is said： Madam is cured the disease based on taste using regulating the qi flowing in the channels as first, and here such as desire regulating the qi flowing in the channels invigorating the spleen person, the work(of orange peel occupies its head.Warm energy promoting the circulation of qi, Xin Neng Diverging, it is bitter and sluice.

【Chemical composition】Containing volatile oil 1.5%（Squeezing method）To 2%（The way of distillation）, oil in main component be D- limonenes（d- limonene）, also containing beta-myrcene（β-myrcene）α-and nopinene（pinene）Deng, another hesperidine containing flavones ingredient, Neohesperidin（neohesperidin）, naringenin（Tangeretin, 5,6,7,8,4 '-pentamethoxyflavone）, two Hydrogen Nobiletin（Citromitin, 5,6,7,8,3 ', 4 '-hexamethoxyflavanone）And 5- removes first dihydro Nobiletin （5-O-desmethyl-citromitin）；Report river dried orange peel is containing hesperidine about 8.4%, Nobiletin again（nobiletin）About 0. 15%. separately contain synephrine.

Selfheal【Nature and flavor】Toil is trembled with fear.【Channel tropism】Enter liver, gallbladder channel.【Major function】It clears liver, dissipating bind.Control scrofula, goiter and tumor, Acute mastitis, breast cancer, mesh pearl nyctalgia, photophobia are shed tears, vertigo, facial paralysis, arthralgia and myalgia, pulmonary tuberculosis, and acute icteric infects Property hepatitis, metrorrhagia, band under.①《This warp》：" main fever and chills, scrofula, mouse fistula, head sore break disease, dissipate goitre knot gas, and foot swells arthritis with fixed pain caused by dampness."② 《A supplement to augmented materia medica》：" take a tonic or nourishing food to build up one's health blood vessels."③《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" liver wind of dispelling, network of passing through control facial paralysis.Row irritability, opens liver It is strongly fragrant, only arthralgia and myalgia, ophthal malgia, dissipate scrofula steal, whole body tuberculosis."④《Sward pharmacological property is standby will》：" phlegm is gone to disappear purulence, controls scrofula, it is clear on Under benefit, eye mask is removed, is relieved pain."⑤《The new compilation of materia medica》：" control scrofula, mouse fistula, goiter and tumor, Disorder heavily fortified points, acute mastitis, mammary cancer."⑥《The people of science Between medicinal herbs》：" there is diuresis bactericidal effect.Decoction can wash wound, control suppurative outer disease, wash vagina, control vaginal orifice and uterine mucosa It is scorching."⑦《Modern Practical Chinese medicinal》：It is " effective to gonorrhoea, hysteropathy for diuretics；And hypertension can be controlled, blood pressure can be declined."

【Chemical analysis】Herb contain triterpenoid saponin, glucoside member is oleanolic acid, still containing free oleanolic acid, ursolic acid, Rutin, hyperin, cis- caffeic acid, trans- caffeic acid, vitamin B1, vitamin C, vitamin K, carrotene, resin, hardship Taste matter, tannin, volatile oil, alkaloid, water soluble salt（About 3.5%, wherein about 63% is potassium chloride）Deng.Flower spike contains delphinium Anthocyanin, d- camphors, d- fenchones, the ursolic acid of element and Cyanidin.

Fructus Corni【Nature and flavor】Acid, tepor.【Channel tropism】Enter liver and kidney channel.【Major function】Filling liver kidney, puckery vital essence, Gu collapse.It controls Soreness of waist and knee joint, dizziness, tinnitus, impotence, seminal emission, frequent urination, liver cold of insufficiency type heat, incessant sweating due to debility, the heart shake arteries and veins and dissipate.It tonifies the liver and kidney, it is puckery Smart prevent prolapse.For under dizziness and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, uterine bleeding band, profuse sweating collapse, Heat Diabetes.Temperature Liver kidney tonifying, except a wind cutting, only menorrhalgia, punish-old human urine frequency.①《This warp》：" perverse trend fever and chills under the main heart, middle benefit gas, by cold-dampness numbness, Go three worms."②《Lei Gong Pao Zhi Lun》：" strong vigour, secret essence."③《It does not record》：" stomach ailment said due to cold or exposure, fever and chills hernia lump in the abdomen, intermittent headache, general mood are gone To come, nasal obstruction, mesh is yellow, deaf, pimples, middle benefit gas, and lower gas is perspired, Qiang Yin, strengthening the essence, and five viscera settling leads to nine orifices, only diuresis, improving eyesight, Strongly."④《Haigoushen》：" brain ostalgia is controlled, only the moon, water was indefinite, kidney tonifying gas；Xing Yangdao adds marrow, treats tinnitus, main except sore on face Can sweating, only old man urine do not save."⑤《Japan hanako materia medica》：" warm waist and knee, helps water dirty, except a wind cutting, cuts gas one by one, breaks Disorder knots, Control wine Zha."⑥《Pearl sac》：" warm liver."⑦《Book on Chinese herbal medicine asks former》：" only chronic diarrhea, fever sweating of having a guilty conscience."

【Chemical analysis】Fructus Corni pulp contains tannin compositions：Fructus Corni tan hair（Cornus-tannin) 1,2,3, Fructus Corni Tannin 1 is different terchebin（) also known as water chestnut category tannin isoterchebin（), trapain Fructus Corni tannin 2 is new miterwort Element II（Tel-limagrandin II), Fructus Corni tannin 2 is new miterwort element I（tellima-grandinⅠ）；Wooden tannin （Cornusiin) A, B, C, G, clove tree tannin（Eugeniin), yellow avens tannin D（GeminD) and bis--O- of 2,3- is not eaten Sub- acyl glucose（2,3-di-O-glloy- β-D-glucose), 1,2,3- tri--O- galloyl glucoses（1,2,6-tri-O- Galloyl- β-D-glucose), 1,2,6-dg-O-D-glucose), 1,2,6- tri--O- galloyl glucoses（1、2、6- tetro-O-galloyl-β-D-glucose).Glucoside-containing ingredient again；Fructus Corni splits glucoside（Cornuside), morroniside （), morroniside 7-O- methyl morroniside（7-O-methylmorroniside), vomiting nut glucoside（Loganin), when Medicine glucoside（sweroside).Also contain glucose（Glucose), fructose（Fructose), sucrose（Su-crose), ursolic acid （Ursolicacid) [5], gallic acid（Gallicacid), malic acid（Malicacid), tartaric acid（tartaricacid) And vitamin A（VitaminA) etc..Contain again and give as security hair oil, therefrom isolated 9 monoterpene hydrocarbon, 6 sequiterpene hydrocarbon, 5 aliphatic hydrocarbons, 7 monoterpene esters and fatty alcohol, 4 monoterpene aldehyde and ketone, 3 fatty aldehydes and ketone, 4 acid, 18 esters and 15 aromatic compounds, The wherein more main component of content has：Isobutanol（Isobutylalcohol), butanol（Butanol), isoamyl alcohol （), isoanylalcohol cis- and trans- camphor tree alcohol oxide of premeditating（linalool）, furfural（Furfural), β-benzene has been Alcohol（β-phenylethylalcohol), methyleugenol（Methyleugenol), elemicine（Elemicin), it is different thin Pungent bridal veil（Isoasarone), palmitic acid ester（Ethylpalmitate), oleic acid ester（Ethyloleate), linoleic acid ester （Ethyllinoleate), benzyl cinnamate（Benzylcinnamate), palmitic acid（Palmiticacid), stearic acid （Stearicacid), alpha-terpineol（α-terpi-neol), α-curcumene（α curcumene), anethole（Anethole), 4- Methoxyl group -1,2- benzodioxole（4-methoxy-1,2-benzodioxole), asarone（Asaricin), horse Pocket bell ketone（Aristolone), basic note oxalaldehyde（Ethylvanillin), leukotrienes ester（Ethyllinolenate), it is recklessly thin Lotus ketone（Pulegone), safrole（Safrole) etc..Contain linoleic acid in core（Linoleicacid), oleic acid（Oleicacid), Palmitic acid（Palmiticacid), stearic acid（Stearicacid), leukotrienes（Linolenicacid), lauric acid （21 kinds of elements such as aliphatic acid and iron, aluminium, copper, zinc, boron, phosphorus such as lauricacid).Contain threonine in pulp and core （Threonine), valine（Valine), leucine（Leucine), isoleucine（Isoleucine), phenylalanine （Phenylalanine), histidine（Histidine), lysine（Lysine), serine（Serine), glutamic acid （Glutam-icacid), glycine（Glycine), alanine（Alanine), tyrosine（Tyrosine), arginine （Arginine), aspartic acid（14 kinds of amino acid such as asparticacid) also separately have methionine in core（Methionine), dried meat Propylhomoserin（Proline), cystine（cystine).

Pawpaw【Nature and flavor】Acid, temperature.【Channel tropism】Enter liver, the spleen channel.【Major function】Suppressing the hyperactive liver and easing the stomach, dry relaxing muscles and tendons.Vomiting and diarrhoea is controlled to turn Muscle, arthritis with fixed pain caused by dampness, tinea pedis, oedema, dysentery.①《Lei Gong Pao Zhi Lun》：" battalion is adjusted to defend, helps essence derived from food."②《It does not record》：" main arthritis with fixed pain caused by dampness perverse trend, suddenly It disorderly spits down greatly, convulsion is more than."③《Dietetic materia medica》：" land measure of 30 mu general mood of vomitting is controlled, is had a cramp after spitting, liquor drinks it."④《Book on Chinese herbal medicine, which picks up, to be sent》：" Lower cold air, strengthening the bones and muscles help digestion, thirsty more than after sealing dysentery, make drink-service it.Disease of weak foot affecting heart again takes one to remove son, decoction it, tender person More preferably.Preventing or arresting vomiting is inverse again, heart diaphragm phlegm saliva."⑤《Haiyao Bencao, Oversea Materia Medica》：It " astringes the lung and stomach, reason spleen cuts down liver, helping digestion is quenched the thirst."⑥《Solar corona is originally Grass》：" antiemetic rushes down run quickly globefish and tinea pedis oedema, cold and hot dysentery, and pain in the chest and abdomen is treated thirsty." 7. Wang Haogu：It " dries and stomach, grows spleen benefit lung.It controls Abdominal distension is apt to, and ruffian is tired of under the heart."⑧《Daily book on Chinese herbal medicine》：" it controls and is attacked in tinea pedis, leg knee pain, detumescence of quenching the thirst."⑨《Book on Chinese herbal medicine is new again》：" Hold back liver and taste, invigorate blood circulation."

【Chemical analysis】Fruit contains malic acid (malicacid) tartaric acid (tartaricacid) citric acid (citricacid) and saponin, also containing oleanolic acid (oleanolicacid).

Dark plum【Nature and flavor】Acid, temperature.【Channel tropism】Enter liver, spleen, lung, large intestine channel.【Major function】Convergence is promoted the production of body fluid, claming ascaris expelling parasite. Control chronic cough, abnormal heat polydipsia, chronic malaria, chronic diarrhea, dysentery has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract abdominal pain, vomiting, hookworm disease, psoriasis, Nu Meat.①《This warp》：" main lower gas, except hot dysphoria, feels at ease, and limbs pain, hemiplegia meciless, dead flesh removes green black mole, dislikes meat."②《Not Record》：" only diarrhea, good saliva dry." " profit tendon and vessel, goes numbness." 3. Tao Hongjing：" typhoid fever dysphoria with smothery sensation, water stain drink juice." 4. Meng's numerous：" stool Obstructed, gas, which is run quickly, to be intended to dead, with dark plum ten, is put in soup, and moment Norway stonings, pestle is big for ball such as jujube, receives lower part, is led to when few.Thumb is broken It is water stain, with it is few honey mutually and, quench the thirst.Cholera trusted subordinate is uneasy and dysentery is red, preventing and curing malaria side is mostly used it."⑤《Bencao Shiyi》：" phlegm is removed, it is main Malaria miasma, in the tune that quenches the thirst, except cold and hot dysentery, antiemetic is inverse."⑥《Japan hanako materia medica》：" except labor, hectic fever due to yin is controlled, goes unhappiness, antidysentery with astringent disappears Wine poison controls hemiplegia skin paralysis, removes stain, make us sleeping.Enter to build again tea, rhizoma zingiberis be ball, dysentery stopping."⑦《This sketch Through》：" main typhoid fever dysphoria with smothery sensation and cholera are hot-tempered thirsty, and consumptive disease is thin thin, it is mostly used in the sides such as puerpera's diarrhea due to disorder of qi."⑧《Medication heart method》：" receive lung Gas."⑨《Detailed outline》：" puckery intestines of astringing the lung, control and cough long, and rush down dysentery, gastric disorder causing nausea is dysphagic, and the ascariasis of biliary tract spits profit, detumescence, gush phlegm, desinsection, solution ichthyotoxin, horse Sweat poison, Sulfur poison."⑩《Book on Chinese herbal medicine asks former》：" control haematuria, lower blood, all blood troubles, spontaneous perspiration, dryness of the mouth and throat."

【Chemical analysis】Fruit edge containing Chinese holly acid (citricacid), malic acid (malicacid), oxalic acid (oxalicacid), succinic acid (succinicacid) and fumaric acid (fumaricacid) total acid content about 4%-5.5%, in the past The content of two kinds of organic acids is more.Also (5-hydroxymethyl-2-furaldehyde) containing HMF 5 hydroxymethyl 2 furaldehyde is nothing Color grease.Contained volatile ingredient mainly has benzaldehyde (benzaldehyde) 62.40%, 4- terpinenols (terpinen- 4-ol) 3.97%, benzyl alcohol (benzylalcohol) 3.97% and hexadecanoic acid (hexadecanoicacid) 4.55%.Dark plum benevolence Containing amygdalin (amygdalin) about 0.5%, and Mei Renhan about 4.3%.Also contain picric acid in dark plum according to another report (picricacid) and superoxide dismutase (SOD).

Granatum【Nature and flavor】Sour and astringent, temperature is toxic.【Channel tropism】Enter large intestine, kidney channel.【Major function】Puckery intestines, hemostasis, expelling parasite. Chronic diarrhea is controlled, protracted dysentery is had blood in stool, rectal prolapse, involuntary emission, uterine bleeding, under band, abdominal pain due to enterositosis, mange.①《It does not record》：" treat diarrhea, leak-stopping essence." ②《Haigoushen》：" muscles and bones wind is controlled, waist foot is unsuccessful, walking contraction urgency pain.Puckery intestines are led, only red white diarrhea.Juice is taken to stop under mesh tear, is controlled Leakage essence."③《Bencao Shiyi》：" main roundworm.Decoction."④《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" with the passing of time watery diarrhea is controlled, simmers clothes, and control dysentery with granulated sugar is fried Purulence blood, blood under large intestine." " decocts with birthwort controls children infantile malnutrition due to digestive disturbances or intestinalparasites worm."⑤《Book on Chinese herbal medicine covers bamboo fish trap》：" reason decayed tooth."⑥《Detailed outline》：" antidiarrheal dysentery, Lower blood, rectal prolapse, under metrorrhagia band."⑦《Sward pharmacological property is standby will》：" tumor sore is controlled, washes colic."⑧《Book on Chinese herbal medicine asks former》：" wash spot, scabies Leprosy."⑨《The civil medicinal herbs of science》：" drive away hook, tapeworm."

【Chemical analysis】Pericarp contains tannin（Tannin), wax（Wax), tree fat（Resin), mannitol（D- Mannitol), mucilaginous substance（Mucilage), gallic acid（Galicacid), malic acid（Amlicacid), pectin（pectin) And calcium oxalate（Calciumoxalate), it is gummy（Gum), synanthrin（Inulin), non-crystallizable sugars.Get from tannin：Granatum Bitter principle（Granatin) A, B, Tannin in Punica granatum L（Punicalin), 2,3-O- connects two nutgall acyl Tannin in Punica granatum L （punicalagin).Pericarp also contains elaidic acid（Elaidicaicd), Isoquercitrin（Isoquercetrin), Cyanidin -3- Glycoside cyanidin-3-glucoside), Cyanidin -3,5- glucosulfone（Cyanindin-3, -5- Diglucosede), crow line India element -3- glycosides（Pelargonidin-3-glucoside), crow line India element -3,5- Diglucoside（Pelargonidin-3,5-diglucoside).Get four poly- nutgalls from the methanolic extract of pericarp again Acid（Tetramericgallicacid), there is the activity for inhibiting carbonic acid dehydrogenase.

Pericarp, stem skin, bark containing alkaloid, it is separated go out：Granatenine（Pel-letierine, punicine), it is different Granatenine（Isopelletierine), pseudo- granatenine（Pseudopelletierine), N- methylisopelletierines（N- Methylisopelletie-rine) etc..It is isolated from tannin contained by bark again：Tannin in Punica granatum L, 2,3-O- connect two and do not eat Sub- acyl Tannin in Punica granatum L, 2-O- nutgall acyls -4,6-（S, s) benzoaric acid connects two nutgall acyls-D-Glucose [2-O- Galloyl-4,6）S, s)-gallgyl-D-glu-cose], 2,3-（s）Hexahydroxy biphenyl diformyl-D-Glucose [2,3- （s）- hexahy-droxydiphenoyl-D- glucose [6-O-galloyl-2,3- (s)-hexahydroxydiphenoyl- D-glucose], long A, B, C, D, granatum gluconic acid（Punigluconin), horse-tail tannin（Cacortein), wood fiber crops Yellow tan is peaceful.

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, is made of the bulk pharmaceutical chemicals of following weight proportion：

10-25 parts of propolis, 10-18 parts of radix-polygoni multiflori extract, 10-15 parts of haw thorn extract, is determined at 5-15 parts of earth-worm extractive as raw material 10-15 parts of pine torch extract, 10-20 parts of wax gourd bark extract, 10-18 parts of Salvia root P.E, 10-18 parts of angelica extract, day 10-22 parts of nettle extract, 15-25 parts of uncaria extract, 6-12 parts of safflower extract, 5-12 parts of hirudo extract, astragalus extraction 12-20 parts of object, 10-21 parts of dried orange peel extracts, 15-25 parts of Prunella vulgaris extract, 10-20 parts of cornel extractive, pawpaw extraction 10-15 parts of object, 8-15 parts of smoked plum extractive, 8-15 parts of pomegranate rind extract, 5-10 parts of mandarin orange extract, apple extract 5-10 Part, 6-12 parts of grape extract, 8-15 parts of Caulis Sacchari sinensis extract；

Earth-worm extractive as raw material：Dry earthworm is taken, adds 8 times of 75% ethyl alcohol of amount of volume, refiner homogenate carries out 3 refluxing extractions, It 40 minutes every time, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Radix-polygoni multiflori extract：The dry fleece-flower root is taken to be ground into 20-30 mesh, 65% ethyl alcohol for adding in 10 times of amounts of volume impregnates 30 Minute, microwave treatment 45 seconds carries out 2 refluxing extractions, 30 minutes every time, recycles ethyl alcohol, crossing No. 5 sieves after vacuum concentration is dry is ；

Haw thorn extract：Haw berry is taken, adds in 75% ethyl alcohol of 10 times of amounts of volume, ultrasound 3 times 45 minutes every time, recycles second Alcohol is crossed No. 5 after vacuum concentration is dry and is sieved to obtain the final product；

Cassia seed extract：Depending on pine torch, add in 65% ethyl alcohol of 8 times of amounts of volume, ultrasonic 1h carries out 3 refluxing extractions, It 40 minutes every time, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Wax gourd bark extract：Waxgourd peel is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merges concentration To density 1.05, it is 80% to add 70% ethyl alcohol to alcohol content, and precipitation stands 8 h, recycles ethyl alcohol, No. 5 sieves are crossed after vacuum concentration is dry To obtain the final product；

Angelica extract：By Radix Angelicae Sinensis coarse crushing, absolute ethyl alcohol is added in 40-45 DEG C of extraction temperature, extracting pressure 28-32MPa, Parse pressure 9-12 MPa, CO₂Extraction 8 hours is carried out under conditions of flow 10-12L/h, recycles ethyl alcohol, after being concentrated in vacuo drying No. 5 are crossed to sieve to obtain the final product；

Salvia root P.E：8 times of amount water will be added in after Radix Salviae Miltiorrhizae coarse crushing to impregnate 2 hours, heating and refluxing extraction 3 hours, extraction 3 It is secondary, merge extracting solution, filter, concentration；By concentrate reverse phase silica gel column separating purification；Eluent is collected in elution 3 times, is concentrated, No. 5 are crossed after vacuum drying to sieve to obtain the final product；

Rhizoma Gastrodiae extract：It by Rhizoma Gastrodiae coarse crushing, is extracted using water extraction, adds activated carbon decolorizing, filter to obtain extracting solution, it is dense Contracting, with 95% ethanol precipitation, overnight, ethyl alcohol is recycled in centrifugation, crosses No. 5 after vacuum drying and sieves to obtain the final product；

Uncaria extract：By uncaria coarse crushing, extracted 3 hours, extracted 3 times with 65% alcohol reflux of 8 times of amounts of volume；It will be upper State filtrate merge filter, be concentrated under reduced pressure recycling ethyl alcohol obtain just extract, then with 95% ethyl alcohol, purified water rinse reuse；It will be upper Just extract extraction is stated, stands, filter, obtains crude extract；Above-mentioned crude extract with macroporous resin column is adsorbed, is eluted, recycling Eluent is crossed No. 5 after vacuum drying and is sieved to obtain the final product；

Safflower extract：Will dry safflower coarse crushing, with 95% ethyl alcohol of 7 times of amounts of volume to coarse crushing object refluxing extraction 4 hours, It is extracted 2.5 hours, filter centrifugation, is filtered within 4 hours with 95% ethyl alcohol alcohol precipitation after supernatant concentration, very at 95 DEG C with 6 times of waters again No. 5 are crossed after sky is dry to sieve to obtain the final product；

Hirudo extract：Dry leech is taken, adds 8 times of 75% ethyl alcohol of amount of volume, refiner homogenate carries out 3 refluxing extractions, It 40 minutes every time, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Astragalus Root P.E：Radix Astragali is impregnated into 2h, boiling 2 times decocts 2h every time, and filtering obtains filtrate and filter residue；Filter residue is used 65% ethyl alcohol heating and refluxing extraction 2 times merges extracting solution and above-mentioned filtrate；By amalgamation liquid macroporous resin adsorption and elution 3 It is secondary, recycle eluent, concentration is crossed No. 5 after vacuum drying and sieved to obtain the final product；

Dried orange peel extracts：Dried orange peel is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merging is concentrated into close 1.08-1.2 is spent, it is 85% to add 80% ethyl alcohol to alcohol content, and precipitation is stood overnight, and recycles ethyl alcohol, and No. 5 sieves are crossed after being concentrated in vacuo drying To obtain the final product；

Prunella vulgaris extract：Selfheal is impregnated into 2h, boiling 2 times decocts 2h every time, and filtering obtains filtrate and filter residue；It will filter 65% ethyl alcohol heating and refluxing extraction 2 times of slag, merges extracting solution and above-mentioned filtrate；By amalgamation liquid macroporous resin adsorption and wash It is 3 times de-, recycle eluent, concentration is crossed No. 5 after vacuum drying and sieved to obtain the final product；

Cornel extractive：Fructus Corni is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merges concentration To density 1.08, it is 80% to add 70% ethyl alcohol to alcohol content, and precipitation stands 8 h, recycles ethyl alcohol, No. 5 sieves are crossed after vacuum concentration is dry To obtain the final product；

Papaya extractives：By pawpaw pulp coarse crushing, absolute ethyl alcohol is added in 40-45 DEG C of extraction temperature, extracting pressure 28- 32MPa, parsing pressure 9-12 MPa, CO₂Extraction 8 hours is carried out under conditions of flow 10-12L/h, recycles ethyl alcohol, is concentrated in vacuo No. 5 are crossed after drying to sieve to obtain the final product；

Smoked plum extractive：Dark plum coarse crushing will be enucleated, the water of 6 times of amounts is added to decoct 3 times, 1.5 hours every time, is merged after filtering every Secondary filtrate, filtrate add in 95% ethyl alcohol after being condensed into thick paste, and thick paste alcohol content is made to stand overnight, be concentrated after filtering up to 60~80%, No. 5 are crossed after vacuum concentration is dry to sieve to obtain the final product；

Pomegranate rind extract：Granatum is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merges concentration To density 1.05, it is 70% to add 65% ethyl alcohol to alcohol content, and precipitation stands 8h, recycles ethyl alcohol, and crossing No. 5 sieves after vacuum concentration is dry is ；

Mandarin orange extract：Mandarin orange coarse crushing is taken, adds in 65% ethyl alcohol of 6 times of amounts of volume, ultrasonic power 350w is extracted 40 minutes, is returned It receives ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Apple extract：By apple coarse crushing, absolute ethyl alcohol is added in 50 DEG C, extracting pressure 30-40MPa of extraction temperature, solution Analyse pressure 9-12 MPa, CO₂Extraction 5 hours is carried out under conditions of flow 15-20L/h, recycles ethyl alcohol, is concentrated in vacuo mistake after drying No. 5 are sieved to obtain the final product；

Grape extract：By grape coarse crushing, absolute ethyl alcohol is added in 45-55 DEG C of extraction temperature, extracting pressure 40MPa, solution Analyse pressure 10-12 MPa, CO₂Extraction 8 hours is carried out under conditions of flow 18-25L/h, recycles ethyl alcohol, after being concentrated in vacuo drying No. 5 are crossed to sieve to obtain the final product；

Caulis Sacchari sinensis extract：By sugarcane coarse crushing, absolute ethyl alcohol is added in 50 DEG C, extracting pressure 45MPa of extraction temperature, parsing pressure Power 9-12 MPa, CO₂Extraction 5 hours is carried out under conditions of flow 10-15L/h, recycles ethyl alcohol, No. 5 are crossed after being concentrated in vacuo drying It sieves to obtain the final product.

A kind of improvement blood viscosity and the combination agent of hematoblastic aggregation, the bulk pharmaceutical chemicals of which part weight proportion For：11-24 parts of propolis, 6-14 parts of earth-worm extractive as raw material, 11-17 parts of radix-polygoni multiflori extract, 11-17 parts of haw thorn extract, cassia seed 11-17 parts of extract, 11-19 parts of wax gourd bark extract, 11-17 parts of Salvia root P.E, 11-17 parts of angelica extract, Rhizoma Gastrodiae carries Take 11-21 parts of object, 16-24 parts of uncaria extract, 7-11 parts of safflower extract, 6-11 parts of hirudo extract, Astragalus Root P.E 13- 19 parts, 11-20 parts of dried orange peel extracts, 16-24 parts of Prunella vulgaris extract, 11-19 parts of cornel extractive, papaya extractives 11- 17 parts, 9-14 parts of smoked plum extractive, 9-14 parts of pomegranate rind extract.

A kind of improvement blood viscosity and the combination agent of hematoblastic aggregation, the bulk pharmaceutical chemicals of which part weight proportion For：12-23 parts of propolis, 7-13 parts of earth-worm extractive as raw material, 12-16 parts of radix-polygoni multiflori extract, 12-16 parts of haw thorn extract, cassia seed 12-16 parts of extract, 12-18 parts of wax gourd bark extract, 12-16 parts of Salvia root P.E, 12-16 parts of angelica extract, Rhizoma Gastrodiae carries Take 12-20 parts of object, 17-23 parts of uncaria extract, 8-10 parts of safflower extract, 7-10 parts of hirudo extract, Astragalus Root P.E 14- 18 parts, 12-19 parts of dried orange peel extracts, 17-23 parts of Prunella vulgaris extract, 13-17 parts of cornel extractive, papaya extractives 13- 15 parts, 10-13 parts of smoked plum extractive, 10-13 parts of pomegranate rind extract.

A kind of improvement blood viscosity and the combination agent of hematoblastic aggregation, the bulk pharmaceutical chemicals of which part weight proportion For：6-9 parts of mandarin orange extract, 6-9 parts of apple extract, 7-11 parts of grape extract, 9-14 parts of Caulis Sacchari sinensis extract.

A kind of improvement blood viscosity and the combination agent of hematoblastic aggregation be by the extract of the bulk pharmaceutical chemicals by It is filling into capsule or directly as oral powder according to ratio.

Usefulness of the present invention is：Propolis, Astragalus Root P.E moisturizing myogenic, anti-inflammatory analgetic in combination agent of the present invention；Certainly Pine torch extract heat-clearing improving eyesight, relaxes bowel；Waxgourd peel, papaya extractives inducing diuresis for removing edema, dry relaxing muscles and tendons；Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, safflower Extract promoting blood circulation, apocenosis, analgesic；Rhizoma Gastrodiae, uncaria extract ceases wind, arresting convulsion, are aided with selfheal clearing liver dissipating bind；In addition water Leech, earth-worm extractive as raw material heat-clearing, removing obstruction inchannels to removing blood stasis；Hawthorn, dried orange peel extracts regulating qi-flowing for strengthening spleen dissipate the stasis of blood in tune；The fleece-flower root, Fructus Corni extraction Object filling liver kidney, blood-nourishing, wind-dispelling；Dark plum, pomegranate rind extract convergence are promoted the production of body fluid, puckery intestines, hemostasis；Mandarin orange, apple, grape, sweet in addition Rich in tartaric acid in sugarcane extract, body cell reparation is helped, the haemocyte dissociation of aggregation is effectively facilitated, restores normal condition, it is right The disease being affected by it has adjuvant treatment effect.

Description of the drawings

Fig. 1 is blood inner cell form photo under microscope before case 1 takes combination agent of the present invention；

Fig. 2 is blood inner cell form photo under microscope after case 1 takes combination agent of the present invention；

Fig. 3 is blood inner cell form photo under microscope before case 2 takes combination agent of the present invention；

Fig. 4 is blood inner cell form photo under microscope after case 2 takes combination agent of the present invention；

Fig. 5 is blood inner cell form photo under microscope before case 3 takes combination agent of the present invention；

Fig. 6 is blood inner cell form photo under microscope after case 3 takes combination agent of the present invention；

Fig. 7 is blood inner cell form photo under microscope before case 4 takes combination agent of the present invention；

Fig. 8 is blood inner cell form photo under microscope after case 4 takes combination agent of the present invention；

Fig. 9 is blood inner cell form photo under microscope before case 5 takes combination agent of the present invention；

Figure 10 is blood inner cell form photo under microscope after case 5 takes combination agent of the present invention；

Figure 11 is blood inner cell form photo under microscope before case 6 takes combination agent of the present invention；

Figure 12 is blood inner cell form photo under microscope after case 6 takes combination agent of the present invention；

Figure 13 is blood inner cell form photo under microscope before case 7 takes combination agent of the present invention；

Figure 14 is blood inner cell form photo under microscope after case 7 takes combination agent of the present invention；

Figure 15 is blood inner cell form photo under microscope before case 8 takes combination agent of the present invention；

Figure 16 is blood inner cell form photo under microscope after case 8 takes combination agent of the present invention.

Specific embodiment

Embodiment 1

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, the bulk pharmaceutical chemicals including following weight proportion are made：

10 parts of propolis, 5 parts of earth-worm extractive as raw material, 10 parts of radix-polygoni multiflori extract, 10 parts of haw thorn extract, cassia seed extract 10 Part, 10 parts of wax gourd bark extract, 10 parts of Salvia root P.E, 10 parts of angelica extract, 10 parts of Rhizoma Gastrodiae extract, uncaria extract 15 Part, 6 parts of safflower extract, 5 parts of hirudo extract, 12 parts of Astragalus Root P.E, 10 parts of dried orange peel extracts, Prunella vulgaris extract 15 Part, 10 parts of cornel extractive, 10 parts of papaya extractives, 8 parts of smoked plum extractive, 8 parts of pomegranate rind extract；

Earth-worm extractive as raw material：Dry earthworm is taken, adds 8 times of 75% ethyl alcohol of amount of volume, refiner homogenate carries out 3 refluxing extractions, It 40 minutes every time, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Radix-polygoni multiflori extract：The dry fleece-flower root is taken to be ground into 20-30 mesh, 65% ethyl alcohol for adding in 10 times of amounts of volume impregnates 30 Minute, microwave treatment 45 seconds carries out 2 refluxing extractions, 30 minutes every time, recycles ethyl alcohol, crossing No. 5 sieves after vacuum concentration is dry is ；

Haw thorn extract：Haw berry is taken, adds in 75% ethyl alcohol of 10 times of amounts of volume, ultrasound 3 times 45 minutes every time, recycles second Alcohol is crossed No. 5 after vacuum concentration is dry and is sieved to obtain the final product；

Cassia seed extract：Depending on pine torch, add in 65% ethyl alcohol of 8 times of amounts of volume, ultrasonic 1h carries out 3 refluxing extractions, It 40 minutes every time, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Wax gourd bark extract：Waxgourd peel is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merges concentration To density 1.05, it is 80% to add 70% ethyl alcohol to alcohol content, and precipitation stands 8 h, recycles ethyl alcohol, No. 5 sieves are crossed after vacuum concentration is dry To obtain the final product；

Angelica extract：By Radix Angelicae Sinensis coarse crushing, absolute ethyl alcohol is added in 40-45 DEG C of extraction temperature, extracting pressure 28-32MPa, Parse pressure 9-12 MPa, CO₂Extraction 8 hours is carried out under conditions of flow 10-12L/h, recycles ethyl alcohol, after being concentrated in vacuo drying No. 5 are crossed to sieve to obtain the final product；

Salvia root P.E：8 times of amount water will be added in after Radix Salviae Miltiorrhizae coarse crushing to impregnate 2 hours, heating and refluxing extraction 3 hours, extraction 3 It is secondary, merge extracting solution, filter, concentration；By concentrate reverse phase silica gel column separating purification；Eluent is collected in elution 3 times, is concentrated, No. 5 are crossed after vacuum drying to sieve to obtain the final product；

Rhizoma Gastrodiae extract：It by Rhizoma Gastrodiae coarse crushing, is extracted using water extraction, adds activated carbon decolorizing, filter to obtain extracting solution, it is dense Contracting, with 95% ethanol precipitation, overnight, ethyl alcohol is recycled in centrifugation, crosses No. 5 after vacuum drying and sieves to obtain the final product；

Uncaria extract：By uncaria coarse crushing, extracted 3 hours, extracted 3 times with 65% alcohol reflux of 8 times of amounts of volume；It will be upper State filtrate merge filter, be concentrated under reduced pressure recycling ethyl alcohol obtain just extract, then with 95% ethyl alcohol, purified water rinse reuse；It will be upper Just extract extraction is stated, stands, filter, obtains crude extract；Above-mentioned crude extract with macroporous resin column is adsorbed, is eluted, recycling Eluent is crossed No. 5 after vacuum drying and is sieved to obtain the final product；

Safflower extract：Will dry safflower coarse crushing, with 95% ethyl alcohol of 7 times of amounts of volume to coarse crushing object refluxing extraction 4 hours, It is extracted 2.5 hours, filter centrifugation, is filtered within 4 hours with 95% ethyl alcohol alcohol precipitation after supernatant concentration, very at 95 DEG C with 6 times of waters again No. 5 are crossed after sky is dry to sieve to obtain the final product；

Hirudo extract：Dry leech is taken, adds 8 times of 75% ethyl alcohol of amount of volume, refiner homogenate carries out 3 refluxing extractions, It 40 minutes every time, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Astragalus Root P.E：Radix Astragali is impregnated into 2h, boiling 2 times decocts 2h every time, and filtering obtains filtrate and filter residue；Filter residue is used 65% ethyl alcohol heating and refluxing extraction 2 times merges extracting solution and above-mentioned filtrate；By amalgamation liquid macroporous resin adsorption and elution 3 It is secondary, recycle eluent, concentration is crossed No. 5 after vacuum drying and sieved to obtain the final product；

Dried orange peel extracts：Dried orange peel is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merging is concentrated into close 1.08-1.2 is spent, it is 85% to add 80% ethyl alcohol to alcohol content, and precipitation is stood overnight, and recycles ethyl alcohol, and No. 5 sieves are crossed after being concentrated in vacuo drying To obtain the final product；

Prunella vulgaris extract：Selfheal is impregnated into 2h, boiling 2 times decocts 2h every time, and filtering obtains filtrate and filter residue；It will filter 65% ethyl alcohol heating and refluxing extraction 2 times of slag, merges extracting solution and above-mentioned filtrate；By amalgamation liquid macroporous resin adsorption and wash It is 3 times de-, recycle eluent, concentration is crossed No. 5 after vacuum drying and sieved to obtain the final product；

Cornel extractive：Fructus Corni is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merges concentration To density 1.08, it is 80% to add 70% ethyl alcohol to alcohol content, and precipitation stands 8 h, recycles ethyl alcohol, No. 5 sieves are crossed after vacuum concentration is dry To obtain the final product；

Papaya extractives：By pawpaw pulp coarse crushing, absolute ethyl alcohol is added in 40-45 DEG C of extraction temperature, extracting pressure 28- 32MPa, parsing pressure 9-12 MPa, CO₂Extraction 8 hours is carried out under conditions of flow 10-12L/h, recycles ethyl alcohol, is concentrated in vacuo No. 5 are crossed after drying to sieve to obtain the final product；

Smoked plum extractive：Dark plum coarse crushing will be enucleated, the water of 6 times of amounts is added to decoct 3 times, 1.5 hours every time, is merged after filtering every Secondary filtrate, filtrate add in 95% ethyl alcohol after being condensed into thick paste, and thick paste alcohol content is made to stand overnight, be concentrated after filtering up to 60~80%, No. 5 are crossed after vacuum concentration is dry to sieve to obtain the final product；

Pomegranate rind extract：Granatum is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merges concentration To density 1.05, it is 70% to add 65% ethyl alcohol to alcohol content, and precipitation stands 8h, recycles ethyl alcohol, and crossing No. 5 sieves after vacuum concentration is dry is .

By the extract of the bulk pharmaceutical chemicals proportionally and production specification it is filling into capsule.

Embodiment 2

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, the bulk pharmaceutical chemicals including following weight proportion are made：

18 parts of propolis, 10 parts of earth-worm extractive as raw material, 15 parts of radix-polygoni multiflori extract, 13 parts of haw thorn extract, cassia seed extract 13 parts, 15 parts of wax gourd bark extract, 15 parts of Salvia root P.E, 14 parts of angelica extract, 18 parts of Rhizoma Gastrodiae extract, uncaria extract 19 parts, 8 parts of safflower extract, 8 parts of hirudo extract, 17 parts of Astragalus Root P.E, 17 parts of dried orange peel extracts, Prunella vulgaris extract 19 Part, 16 parts of cornel extractive, 13 parts of papaya extractives, 12 parts of smoked plum extractive, 12 parts of pomegranate rind extract.

Method for preparing extractive is the same as embodiment 1.By the extract of the bulk pharmaceutical chemicals proportionally and production specification it is filling Into capsule.

Embodiment 3

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, the bulk pharmaceutical chemicals including following weight proportion are made：

25 parts of propolis, 15 parts of earth-worm extractive as raw material, 18 parts of radix-polygoni multiflori extract, 15 parts of haw thorn extract, cassia seed extract 15 parts, 20 parts of wax gourd bark extract, 18 parts of Salvia root P.E, 18 parts of angelica extract, 22 parts of Rhizoma Gastrodiae extract, uncaria extract 25 parts, 12 parts of safflower extract, 12 parts of hirudo extract, 20 parts of Astragalus Root P.E, 21 parts of dried orange peel extracts, Prunella vulgaris extract 25 parts, 20 parts of cornel extractive, 15 parts of papaya extractives, 15 parts of smoked plum extractive, 15 parts of pomegranate rind extract.

Method for preparing extractive is the same as embodiment 1.By the extract of the bulk pharmaceutical chemicals proportionally and production specification make Into oral powder.

Embodiment 4

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, is made of the bulk pharmaceutical chemicals of following weight proportion：Propolis 11 parts, 6 parts of earth-worm extractive as raw material, 11 parts of radix-polygoni multiflori extract, 11 parts of haw thorn extract, 11 parts of cassia seed extract, waxgourd peel carry Take 11 parts of object, 11 parts of Salvia root P.E, 11 parts of angelica extract, 11 parts of Rhizoma Gastrodiae extract, 16 parts of uncaria extract, safflower extraction 7 parts of object, 6 parts of hirudo extract, 13 parts of Astragalus Root P.E, 11 parts of dried orange peel extracts, 16 parts of Prunella vulgaris extract, Fructus Corni extraction 11 parts of object, 11 parts of papaya extractives, 9 parts of smoked plum extractive, 9 parts of pomegranate rind extract, 5 parts of mandarin orange extract, apple extract 5 Part, 6 parts of grape extract, 8 parts of Caulis Sacchari sinensis extract；

Mandarin orange extract：Mandarin orange coarse crushing is taken, adds in 65% ethyl alcohol of 6 times of amounts of volume, ultrasonic power 350w is extracted 40 minutes, is returned It receives ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Apple extract：By apple coarse crushing, absolute ethyl alcohol is added in 50 DEG C, extracting pressure 30-40MPa of extraction temperature, solution Analyse pressure 9-12 MPa, CO₂Extraction 5 hours is carried out under conditions of flow 15-20L/h, recycles ethyl alcohol, is concentrated in vacuo mistake after drying No. 5 are sieved to obtain the final product；

Grape extract：By grape coarse crushing, absolute ethyl alcohol is added in 45-55 DEG C of extraction temperature, extracting pressure 40MPa, solution Analyse pressure 10-12 MPa, CO₂Extraction 8 hours is carried out under conditions of flow 18-25L/h, recycles ethyl alcohol, after being concentrated in vacuo drying No. 5 are crossed to sieve to obtain the final product；

Caulis Sacchari sinensis extract：By sugarcane coarse crushing, absolute ethyl alcohol is added in 50 DEG C, extracting pressure 45MPa of extraction temperature, parsing pressure Power 9-12 MPa, CO₂Extraction 5 hours is carried out under conditions of flow 10-15L/h, recycles ethyl alcohol, No. 5 are crossed after being concentrated in vacuo drying It sieves to obtain the final product；

Remaining method for preparing extractive is the same as embodiment 1.By the extract of the bulk pharmaceutical chemicals proportionally and production specification It is fabricated to oral powder.

Embodiment 5

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, is made of the bulk pharmaceutical chemicals of following weight proportion：Propolis 12 parts, 7 parts of earth-worm extractive as raw material, 12 parts of radix-polygoni multiflori extract, 12 parts of haw thorn extract, 12 parts of cassia seed extract, waxgourd peel carry Take 12 parts of object, 12 parts of Salvia root P.E, 12 parts of angelica extract, 12 parts of Rhizoma Gastrodiae extract, 17 parts of uncaria extract, safflower extraction 8 parts of object, 7 parts of hirudo extract, 14 parts of Astragalus Root P.E, 12 parts of dried orange peel extracts, 17 parts of Prunella vulgaris extract, Fructus Corni extraction 13 parts of object, 13 parts of papaya extractives, 10 parts of smoked plum extractive, 10 parts of pomegranate rind extract, 6 parts of mandarin orange extract, apple extract 6 Part, 7 parts of grape extract, 9 parts of Caulis Sacchari sinensis extract.

Method for preparing extractive is the same as embodiment 4.By the extract of the bulk pharmaceutical chemicals proportionally and production specification it is filling Into capsule.

Embodiment 6

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, is made of the bulk pharmaceutical chemicals of following weight proportion：Propolis 12 parts, 7 parts of earth-worm extractive as raw material, 12 parts of radix-polygoni multiflori extract, 12 parts of haw thorn extract, 12 parts of cassia seed extract, waxgourd peel carry Take 12 parts of object, 12 parts of Salvia root P.E, 12 parts of angelica extract, 12 parts of Rhizoma Gastrodiae extract, 17 parts of uncaria extract, safflower extraction 8 parts of object, 7 parts of hirudo extract, 14 parts of Astragalus Root P.E, 12 parts of dried orange peel extracts, 17 parts of Prunella vulgaris extract, Fructus Corni extraction 13 parts of object, 13 parts of papaya extractives, 10 parts of smoked plum extractive, 10 parts of pomegranate rind extract, 8 parts of mandarin orange extract, apple extract 8 Part, 10 parts of grape extract, 10 parts of Caulis Sacchari sinensis extract.

Method for preparing extractive is the same as embodiment 4.By the extract of the bulk pharmaceutical chemicals proportionally and production specification it is filling Into capsule.

Embodiment 7

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, is made of the bulk pharmaceutical chemicals of following weight proportion：Propolis 23 parts, 13 parts of earth-worm extractive as raw material, 16 parts of radix-polygoni multiflori extract, 16 parts of haw thorn extract, 16 parts of cassia seed extract, waxgourd peel carry Take 18 parts of object, 16 parts of Salvia root P.E, 16 parts of angelica extract, 20 parts of Rhizoma Gastrodiae extract, 23 parts of uncaria extract, safflower extraction 10 parts of object, 10 parts of hirudo extract, 18 parts of Astragalus Root P.E, 19 parts of dried orange peel extracts, 23 parts of Prunella vulgaris extract, Fructus Corni carry Take 17 parts of object, 15 parts of papaya extractives, 13 parts of smoked plum extractive, 13 parts of pomegranate rind extract, 9 parts of mandarin orange extract, apple extraction 9 parts of object, 11 parts of grape extract, 14 parts of Caulis Sacchari sinensis extract.

Method for preparing extractive is the same as embodiment 4.By the extract of the bulk pharmaceutical chemicals proportionally and production specification it is filling Into capsule.

Embodiment 8

A kind of combination agent for improving blood viscosity and hematoblastic aggregation, is made of the bulk pharmaceutical chemicals of following weight proportion：Propolis 24 parts, 14 parts of earth-worm extractive as raw material, 17 parts of radix-polygoni multiflori extract, 17 parts of haw thorn extract, 17 parts of cassia seed extract, waxgourd peel carry Take 19 parts of object, 17 parts of Salvia root P.E, 17 parts of angelica extract, 21 parts of Rhizoma Gastrodiae extract, 24 parts of uncaria extract, safflower extraction 11 parts of object, 11 parts of hirudo extract, 19 parts of Astragalus Root P.E, 20 parts of dried orange peel extracts, 24 parts of Prunella vulgaris extract, Fructus Corni carry Take 19 parts of object, 17 parts of papaya extractives, 14 parts of smoked plum extractive, 14 parts of pomegranate rind extract, 10 parts of mandarin orange extract, apple extraction 10 parts of object, 12 parts of grape extract, 15 parts of Caulis Sacchari sinensis extract.

Method for preparing extractive is the same as embodiment 4.By the extract of the bulk pharmaceutical chemicals proportionally and production specification make Into oral powder.

Instructions of taking：Disease initial stage：Three times a day, it is equivalent to two grams of bulk pharmaceutical chemicals weight every time；Disease mid-term：Daily three It is secondary, it is equivalent to five grams of bulk pharmaceutical chemicals weight every time；Terminal stage of a disease：Three times a day, it is equivalent to ten grams of bulk pharmaceutical chemicals weight every time；Disease is on the point of Face the phase：Three times a day, it is equivalent to 20 grams of bulk pharmaceutical chemicals weight every time；Or honor doctor's advice is taken.

With specific case come the effect of illustrating Chinese medicine preparation of the present invention.

Case 1：Old * *, man, 52 years old.Suffer from after thrombotic disease 5 years.State is before treatment：Two skelasthenias, 10 centimetres every time of stride Left and right.1 capsule of embodiment is taken, by three times a day, one every time.Continuously take 60 days.Powerless anesthesia, stride restore just Often.

Case 2：King * *, man, 65 years old.Thrombus sequela 6 years.Treat front left skelasthenia, it will be apparent that lift difficulty.Take reality 2 capsule of example is applied by three times a day, is taken 30 days for two every time.Symptom disappears, and restores normal.

Case 3：Liu * *, man, 55 years old.It is narrow that hyperlipemia forms heart arter, vein blood vessel.Face bypass surgery.Clothes With 3 powder of embodiment three times a day, symptom is obviously improved within two months, is withdrawn after four months.

Case 4：Hu * *, man, 65 years old.Once suffered from pulmonary heart disease and varix of lower limb.Hospitalization is recurred after New Year's Day in 2015 More than month, after take 4 powder of embodiment, the state of an illness releases discharge after four weeks.

Case 5：Horse * *, man, 84 years old.Cerebral thrombus after chemotherapy cannot play seat in bed, spoken unclear.Take 5 glue of embodiment Capsule, by three times a day every time three take one month.One month, three times a day, one every time are added after restoring normal again.

Case 6：Nanmu * *, man, 58 years old.Both feet are powerless after suffering from thrombus, difficult upstairs.6 capsule of embodiment is taken, by daily three It is secondary, the previous grain of breakfast, middle each one of evening.Restore after two months normal.

Case 7：Liu * *, man, 64 years old.Formation right crus of diaphragm is powerless after cerebral thrombus, and right crus of diaphragm significantly mops floor on foot.Take embodiment 7 Capsule restores journey after two months.

Case 8：Old * *, female, 67 years old.Thrombus sequela, after hospital abandons treatment.8 capsule of embodiment is taken, 5 Month, it can be with normal walking.

Before attached it can be seen from the figure that does not take combination agent of the present invention, the haemocyte of case 1-8 has a degree of aggregation, Due gap and distance are lost, after taking combination agent of the present invention for a period of time, Blood cell accumulation situation is eased, haemocyte Tend to be normal.

It the above is only the specific embodiment illustrated to explain the present invention, other do not depart from this on the basis of the present invention The variation that the technical solution of invention is done each falls within protection scope of the present invention, and in addition to technology disclosed by the invention, remaining is For the prior art well known to those skilled in the art.

Claims (5)

1. a kind of combination agent for improving blood viscosity and hematoblastic aggregation, it is characterized in that the bulk pharmaceutical chemicals system by following weight proportion Into：

10-25 parts of propolis, 5-15 parts of earth-worm extractive as raw material, 10-18 parts of radix-polygoni multiflori extract, 10-18 parts of haw thorn extract, cassia seed 10-18 parts of extract, 10-20 parts of wax gourd bark extract, 10-18 parts of Salvia root P.E, 10-18 parts of angelica extract, Rhizoma Gastrodiae carry Take 10-22 parts of object, 15-25 parts of uncaria extract, 6-12 parts of safflower extract, 5-12 parts of hirudo extract, Astragalus Root P.E 12- 20 parts, 10-21 parts of dried orange peel extracts, 15-25 parts of Prunella vulgaris extract, 10-20 parts of cornel extractive, papaya extractives 10- 18 parts, 8-15 parts of smoked plum extractive, 8-15 parts of pomegranate rind extract, 5-10 parts of mandarin orange extract, 5-10 parts of apple extract, grape 6-12 parts of extract, 8-15 parts of Caulis Sacchari sinensis extract,

Earth-worm extractive as raw material：Dry earthworm is taken, adds 8 times of 75% ethyl alcohol of amount of volume, refiner homogenate carries out 3 refluxing extractions, every time It 40 minutes, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Radix-polygoni multiflori extract：The dry fleece-flower root is taken to be ground into 20-30 mesh, 65% ethyl alcohol for adding in 10 times of amounts of volume impregnates 30 points Clock, microwave treatment 45 seconds carry out 2 refluxing extractions, 30 minutes every time, recycle ethyl alcohol, crossing No. 5 sieves after vacuum concentration is dry is ；

Haw thorn extract：Haw berry is taken, adds in 75% ethyl alcohol of 10 times of amounts of volume, ultrasound 3 times 45 minutes every time, recycles ethyl alcohol, No. 5 are crossed after vacuum concentration is dry to sieve to obtain the final product；

Cassia seed extract：Depend on pine torch, add in 65% ethyl alcohol of 8 times of amounts of volume, ultrasonic 1h carries out 3 refluxing extractions, every time It 40 minutes, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Wax gourd bark extract：Waxgourd peel is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merging is concentrated into close 1.05 are spent, it is 80% to add 70% ethyl alcohol to alcohol content, and precipitation stands 8h, recycles ethyl alcohol, and crossing No. 5 sieves after vacuum concentration is dry is ；

Angelica extract：By Radix Angelicae Sinensis coarse crushing, absolute ethyl alcohol is added in 40-45 DEG C of extraction temperature, extracting pressure 28-32MPa, parsing Pressure 9-12MPa, CO₂Extraction 8 hours is carried out under conditions of flow 10-12L/h, recycles ethyl alcohol, No. 5 are crossed after being concentrated in vacuo drying It sieves to obtain the final product；

Salvia root P.E：8 times of amount water will be added in after Radix Salviae Miltiorrhizae coarse crushing to impregnate 2 hours, heating and refluxing extraction 3 hours is extracted 3 times, is closed And extracting solution, it filters, concentration；By concentrate reverse phase silica gel column separating purification；Eluent, concentration, vacuum are collected in elution 3 times No. 5 are crossed after drying to sieve to obtain the final product；

Rhizoma Gastrodiae extract：It by Rhizoma Gastrodiae coarse crushing, is extracted using water extraction, adds activated carbon decolorizing, filter to obtain extracting solution, concentrated, With 95% ethanol precipitation, overnight, ethyl alcohol is recycled in centrifugation, crosses No. 5 after vacuum drying and sieves to obtain the final product；

Uncaria extract：By uncaria coarse crushing, extracted 3 hours, extracted 3 times with 65% alcohol reflux of 8 times of amounts of volume；By above-mentioned filter Liquid merge filter, be concentrated under reduced pressure recycling ethyl alcohol obtain just extract, then with 95% ethyl alcohol, purified water rinse reuse；It will be above-mentioned First extract extraction stands, filters, and obtains crude extract；Above-mentioned crude extract with macroporous resin column is adsorbed, is eluted, recycling is washed De- liquid is crossed No. 5 after vacuum drying and is sieved to obtain the final product；

Safflower extract：Will dry safflower coarse crushing, with 95% ethyl alcohol of 7 times of amounts of volume to coarse crushing object refluxing extraction 4 hours, then use 6 times of waters are extracted 2.5 hours at 95 DEG C, filter centrifugation, are filtered within 4 hours with 95% ethyl alcohol alcohol precipitation after supernatant concentration, vacuum No. 5 are crossed after drying to sieve to obtain the final product；

Hirudo extract：Dry leech is taken, adds 8 times of 75% ethyl alcohol of amount of volume, refiner homogenate carries out 3 refluxing extractions, every time It 40 minutes, recycles ethyl alcohol, crosses No. 5 after vacuum concentration is dry and sieve to obtain the final product；

Astragalus Root P.E：Radix Astragali is impregnated into 2h, boiling 2 times decocts 2h every time, and filtering obtains filtrate and filter residue；By filter residue with 65% Ethyl alcohol heating and refluxing extraction 2 times, merge extracting solution and above-mentioned filtrate；It by amalgamation liquid macroporous resin adsorption and elutes 3 times, returns Receive eluent, concentration is crossed No. 5 after vacuum drying and sieved to obtain the final product；

Dried orange peel extracts：Dried orange peel is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merging is concentrated into density 1.08-1.2, it is 85% to add 80% ethyl alcohol to alcohol content, and precipitation is stood overnight, and recycles ethyl alcohol, and No. 5 sieves are crossed after being concentrated in vacuo drying To obtain the final product；

Prunella vulgaris extract：Selfheal is impregnated into 2h, boiling 2 times decocts 2h every time, and filtering obtains filtrate and filter residue；Filter residue is used 65% ethyl alcohol heating and refluxing extraction 2 times merges extracting solution and above-mentioned filtrate；By amalgamation liquid macroporous resin adsorption and elution 3 It is secondary, recycle eluent, concentration is crossed No. 5 after vacuum drying and sieved to obtain the final product；

Cornel extractive：Fructus Corni is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merging is concentrated into close 1.08 are spent, it is 80% to add 70% ethyl alcohol to alcohol content, and precipitation stands 8h, recycles ethyl alcohol, and crossing No. 5 sieves after vacuum concentration is dry is ；

Papaya extractives：By pawpaw pulp coarse crushing, absolute ethyl alcohol is added in 40-45 DEG C of extraction temperature, extracting pressure 28-32MPa, Parse pressure 9-12MPa, CO₂Extraction 8 hours is carried out under conditions of flow 10-12L/h, recycles ethyl alcohol, after being concentrated in vacuo drying No. 5 are crossed to sieve to obtain the final product；

Smoked plum extractive：Dark plum coarse crushing will be enucleated, the water of 6 times of amounts is added to decoct 3 times, 1.5 hours every time, filter every time is merged after filtering Liquid, filtrate add in 95% ethyl alcohol after being condensed into thick paste, and thick paste alcohol content is made to stand overnight, be concentrated after filtering, very up to 60~80% Sky is crossed No. 5 after being concentrated and dried and is sieved to obtain the final product；

Pomegranate rind extract：Granatum is taken to add 10 times of amount water of volume, boiling is extracted 3 times, each 3h, and extracting solution merging is concentrated into close 1.05 are spent, it is 70% to add 65% ethyl alcohol to alcohol content, and precipitation stands 8h, recycles ethyl alcohol, and crossing No. 5 sieves after vacuum concentration is dry is ；

Mandarin orange extract：Mandarin orange coarse crushing is taken, adds in 65% ethyl alcohol of 6 times of amounts of volume, ultrasonic power 350w is extracted 40 minutes, recycling Ethyl alcohol is crossed No. 5 after vacuum concentration is dry and is sieved to obtain the final product；

Apple extract：By apple coarse crushing, absolute ethyl alcohol is added in 50 DEG C, extracting pressure 30-40MPa of extraction temperature, parsing pressure Power 9-12MPa, CO₂Extraction 5 hours is carried out under conditions of flow 15-20L/h, recycles ethyl alcohol, No. 5 sieves are crossed after being concentrated in vacuo drying To obtain the final product；

Grape extract：By grape coarse crushing, absolute ethyl alcohol is added in 45-55 DEG C of extraction temperature, extracting pressure 40MPa, parsing pressure Power 10-12MPa, CO₂Extraction 8 hours is carried out under conditions of flow 18-25L/h, recycles ethyl alcohol, No. 5 are crossed after being concentrated in vacuo drying It sieves to obtain the final product；

Caulis Sacchari sinensis extract：By sugarcane coarse crushing, absolute ethyl alcohol is added in 50 DEG C, extracting pressure 45MPa of extraction temperature, parsing pressure 9- 12MPa, CO₂Extraction 5 hours is carried out under conditions of flow 10-15L/h, recycles ethyl alcohol, crossing No. 5 sieves after vacuum concentration is dry is .

2. a kind of combination agent for improving blood viscosity and hematoblastic aggregation according to claim 1, it is characterized in that by following The bulk pharmaceutical chemicals of weight proportion are made：11-24 parts of propolis, 6-14 parts of earth-worm extractive as raw material, 11-17 parts of radix-polygoni multiflori extract, hawthorn carry 11-17 parts of object, 11-17 parts of cassia seed extract, 11-19 parts of wax gourd bark extract, 11-17 parts of Salvia root P.E are taken, Radix Angelicae Sinensis carries Take 11-17 parts of object, 11-21 parts of Rhizoma Gastrodiae extract, 16-24 parts of uncaria extract, 7-11 parts of safflower extract, hirudo extract 6- 11 parts, 13-19 parts of Astragalus Root P.E, 11-20 parts of dried orange peel extracts, 16-24 parts of Prunella vulgaris extract, cornel extractive 11- 19 parts, 11-17 parts of papaya extractives, 9-14 parts of smoked plum extractive, 9-14 parts of pomegranate rind extract, 5-10 parts of mandarin orange extract, apple 5-10 parts of berry extract, 6-12 parts of grape extract, 8-15 parts of Caulis Sacchari sinensis extract.

3. a kind of combination agent for improving blood viscosity and hematoblastic aggregation according to claim 1, it is characterized in that by following The bulk pharmaceutical chemicals of weight proportion are made：12-23 parts of propolis, 7-13 parts of earth-worm extractive as raw material, 12-16 parts of radix-polygoni multiflori extract, hawthorn carry 12-16 parts of object, 12-16 parts of cassia seed extract, 12-18 parts of wax gourd bark extract, 12-16 parts of Salvia root P.E are taken, Radix Angelicae Sinensis carries Take 12-16 parts of object, 12-20 parts of Rhizoma Gastrodiae extract, 17-23 parts of uncaria extract, 8-10 parts of safflower extract, hirudo extract 7- 10 parts, 14-18 parts of Astragalus Root P.E, 12-19 parts of dried orange peel extracts, 17-23 parts of Prunella vulgaris extract, cornel extractive 13- 17 parts, 13-15 parts of papaya extractives, 10-13 parts of smoked plum extractive, 10-13 parts of pomegranate rind extract, 5-10 parts of mandarin orange extract, 5-10 parts of apple extract, 6-12 parts of grape extract, 8-15 parts of Caulis Sacchari sinensis extract.

4. a kind of combination agent for improving blood viscosity and hematoblastic aggregation according to claim 1, it is characterized in that by following The bulk pharmaceutical chemicals of weight proportion are made：10-25 parts of propolis, 5-15 parts of earth-worm extractive as raw material, 10-18 parts of radix-polygoni multiflori extract, hawthorn carry 10-18 parts of object, 10-18 parts of cassia seed extract, 10-20 parts of wax gourd bark extract, 10-18 parts of Salvia root P.E, Radix Angelicae Sinensis is taken to carry Take 10-18 parts of object, 10-22 parts of Rhizoma Gastrodiae extract, 15-25 parts of uncaria extract, 6-12 parts of safflower extract, hirudo extract 5- 12 parts, 12-20 parts of Astragalus Root P.E, 10-21 parts of dried orange peel extracts, 15-25 parts of Prunella vulgaris extract, cornel extractive 10- 20 parts, 10-18 parts of papaya extractives, 8-15 parts of smoked plum extractive, 8-15 parts of pomegranate rind extract, 6-9 parts of mandarin orange extract, apple 6-9 parts of extract, 7-11 parts of grape extract, 9-14 parts of Caulis Sacchari sinensis extract.

5. according to a kind of combination agent for improving blood viscosity and hematoblastic aggregation of claim 1-4 any one of them, feature Be the combination agent it is that the extract of the bulk pharmaceutical chemicals is proportionally filling into capsule or directly as oral powder.