CN100512858C - Preparation of Chinese traditional medicine for treating cardiovascular disease and cerebrovascular disease - Google Patents

Abstract

A Chinese medicine for treating cardiovascular and cerebrovascular diseases and preventing atherosclerosis is prepared from 28 Chinese-medicinal materials including notoginseng, ginseng, honeysuckle flower, red sage root, etc through immersing, heating, laying aside, and taking supernatant.

Description

A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly is raw material, the pharmaceutical composition that can treat cardiovascular and cerebrovascular disease fast with the Chinese herbal medicine.

Technical background

Hypertension and coronary heart disease all are frequently-occurring disease, the commonly encountered diseases of serious harm health, and both are not only in close relations but also influence each other.Show that according to medical department ASSOCIATE STATISTICS data in the middle of patients with coronary heart disease, nearly about 70% people suffers from hypertension, hypertension is to cause the arteriolar pathological changes of whole body, vasospasm, arteriolosclerosis main cause.The coronary heart disease shape atherosclerotic heart disease that wins again.Atherosclerosis mainly occurs in the large and medium-sized tremulous pulse of health, and main pathological change is that endarterium soaks into deposition because of lipid, forms medicated porridge sample or fiber atheromatous plaque, causes luminal stenosis, tube chamber obstruction, thrombosis.Blood supply insufficiency coronarius causes myocardial ischemia, necrosis, and angina pectoris, myocardial infarction take place, even sudden death.When hypertension, tunica intima, the easy damaged of endotheliocyte, make blood fat easily invade ductus arteriosus wall, impel the formation and the development of atherosclerotic plaque, and the coronary atherosclerosis pathological changes easily causes the renal artery atherosclerotic narrow, hypertension easily takes place or original hypertension is increased the weight of.

At present, the Chinese and western drugs of treatment cardiovascular and cerebrovascular disease is a lot, though the western medicine phase is short, side effect is difficult to radical cure greatly; And treatment by Chinese herbs is stablized, is had no side effect, but curative effect is long.

" a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease " patent of 00103969.5 a kind of patent No. was disclosed on State Intellectual Property Office's Gazette of Patent for Invention is on June 2nd, 2004, it is by Radix Polygoni Multiflori, Radix Rehmanniae Preparata, the Radix Rehmanniae, Radix Asparagi, Radix Ophiopogonis, Radix Angelicae Sinensis, the Cortex Eucommiae, Herba Cistanches, Fructus Lycii, Herba Epimedii, Fructus Schisandrae Chinensis, Semen Cuscutae, Radix Polygalae, Radix Dipsaci, Cacumen Platycladi, Fructus Cnidii, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Scrophulariae, Semen Platycladi, Cortex Cinnamomi, Rhizoma Dioscoreae, Radix Ginseng, the Radix Paeoniae Alba, Poria, Rhizoma Alismatis, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Saposhnikoviae, Semen Coicis, Stigma Croci, Rhizoma Chuanxiong, 33 flavor Chinese herbal medicine such as Cortex Acanthopancis are made, though this invention has certain curative effect to cardiovascular and cerebrovascular disease, curative effect is long.

Summary of the invention

In order to overcome the deficiencies in the prior art, the invention provides a kind of Chinese medicine preparation simple, that can treat cardiovascular and cerebrovascular disease fast for preparing.

The object of the present invention is achieved like this: a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease, form by following component by weight percentage:

Radix Saposhnikoviae 1%～3%, Radix Notoginseng 1%～3%, Radix Ginseng 1%～3%, Fructus Schisandrae Chinensis 1%～3%, Radix Bupleuri 2%～4%, Flos Chrysanthemi 2%～4%, Flos Lonicerae 2%～4%, Cortex Moutan 2%～4%, Cortex Acanthopancis 2%～4%, Rhizoma Atractylodis 2%～4%, Rhizoma Gastrodiae 2%～4%, Radix Angelicae Sinensis 2%～4%, Fructus Corni 2%～4%, the Cortex Eucommiae 2%～4%, Radix Morindae Officinalis 2%～4%, Herba Epimedii 2%～4%, Poria 3%～5%, Radix Puerariae 3%～5%, Fructus Crataegi 3%～5%, Radix Salviae Miltiorrhizae 3%～5%, the Radix Astragali 3%～5%, Fructus Lycii 3%～5%, Caulis Spatholobi 3%～5%, Radix Rehmanniae Preparata 3%～5%, Semen Ziziphi Spinosae 5%～7%, Rhizoma Dioscoreae 5%～7%, Rhizoma Polygonati 5%～7%, Radix Polygoni Multiflori Preparata 5%～7%.

Pharmaceutical composition optimum weight percentage ratio proportioning of the present invention is:

Radix Saposhnikoviae 2%, Radix Notoginseng 2%, Radix Ginseng 2%, Fructus Schisandrae Chinensis 2%, Radix Bupleuri 3%, Flos Chrysanthemi 3%, Flos Lonicerae 3%, Cortex Moutan 3%, Cortex Acanthopancis 3%, Rhizoma Atractylodis 3%, Rhizoma Gastrodiae 3%, Radix Angelicae Sinensis 3%, Fructus Corni 3%, the Cortex Eucommiae 3%, Radix Morindae Officinalis 3%, Herba Epimedii 3%, Poria 4%, Radix Puerariae 4%, Fructus Crataegi 4%, Radix Salviae Miltiorrhizae 4%, the Radix Astragali 4%, Fructus Lycii 4%, Caulis Spatholobi 4%, Radix Rehmanniae Preparata 4%, Semen Ziziphi Spinosae 6%, Rhizoma Dioscoreae 6%, Rhizoma Polygonati 6%, Radix Polygoni Multiflori Preparata 6%.

After above-mentioned 28 kinds of Chinese herbal medicine selection, weighing, carry out roguing work with 20 mesh sieves earlier, 1: 8 times of distilled water according to the Chinese herbal medicine gross weight carries out proportioning then, medicinal liquid is put into soaks post-heating half an hour in the boiling container.After temperature is controlled at 115 degree for the first time, left standstill 1 hour; Carry out decocting the second time, temperature is controlled at more than 100 degree, leaves standstill again again; So digestion process is through 2～3 times, and be 6～7 hours total heat time heating time, is the Chinese herbal medicine gross weight and the ratio of distilled water is 1: 5 until liquor strength, is brownish red.Left standstill clear liquor at normal temperatures 8～10 hours, and filtered the extraction supernatant, according to every bottle of 500 milliliters of medicinal liquids bottling with the macromolecular filter membrane machine.When taking, sooner or later respectively obey each 20～40 milliliters 1 time.

The present invention is according to being Chinese medical theory and modern medical theory, and wherein the compositions in the preparation has mainly been used:

1, Radix Saposhnikoviae:

Claim copper to rue again, fennel rues, fennel grass, screen, wind meat etc., main component is that Radix Saposhnikoviae contains volatile oil, mannitol, bitterness glycoside etc.It is main long-chain fat that root contains 3-0-Radix Angelicae Sinensis acyl hamaudol, 5-0-methyl tooth A Mi alcohol, cupreol, mannitol and lignoceric acid.Cure mainly affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious.Has the wind dispelling effect of inducing sweat.

2, Radix Notoginseng:

Other titles: mountain lacquer, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Wedeliae Wallichii, Radix Notoginseng, Typhonium flagelliforme (Lodd.) Blume, field lacquer, Radix Notoginseng.Main component: root contains ginsenoside Rb1, Rd, Re, Rg1, Rg2, Rh, 20-0-glucose Ginsenoside Rf, arasaponin R1, R2, R3, R4, Herba Gynostemmatis Saponin X VII.Still contain the panaxosideRb2.Contain ginsenoside Rb1, Rb2, Rd, Re, Rg1 and arasaponin R1 in the block rhizome.Bitter in the mouth, little sweet.

Function cures mainly: control haematemesis, and hemoptysis, epistaxis is had blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia falls and pounces on blood stasis, traumatic hemorrhage, carbuncle pain.Have removing stasis to stop bleeding, the analgesic therapy of invigorating blood circulation.

2, Radix Ginseng:

Have another name called people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), Rhizoma Panacis Japonici, HUANGSHEN, Radix Ginseng etc., main component: volatile oil, α-guaiene, β-patchoulene, transcaryophyllene, humulene, γ-elemene, Airy is phenol alkene not, β-farnesene, β-gurjunene, heptadecanol-1.Cure mainly: strongly invigorating primordial QI. invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst. calm the nerves and increase intelligence, control blood deficiency, have that the prosperous sun of gas is improved oneself and the merit of strengthening vital QI to eliminate pathogenic factors.

4, Fructus Schisandrae Chinensis:

Have another name called, profound and, can and, five Fructus Armeniacae Mumes; The main component fruit contains volatile oil approximately, and the sesquialter that volume wherein arranged is alkene, β 2-bisabolence, β-chamigrene and ylangene etc. all.Contain citric acid in the dry fruit, malic acid, and a small amount of tartaric acid.Still contain monosaccharide, resin etc.Cure mainly: control chronic cough of deficiency lung, lung is suffered from a deficiency of the kidney and is coughed, and night sweat is quenched one's thirst, insomnia etc.Have the nourishing kidney of astringing the lung, arresting seminal emission antidiarrheal, promote the production of body fluid, mind tranquilizing and the heart calming, can control quench one's thirst, chronic hepatitis, the neurasthenia.

5, Radix Bupleuri:

Claim soft Radix Bupleuri, hard Radix Bupleuri, wine Radix Bupleuri, Radix Bupleuri (processed with vinegar) etc. again.Main component is for containing volatile oil, bupleurumol, oleic acid, linolenic acid, Palmic acid, stearic acid, carnaubic acid, glucose and Saponin etc.Has the dispersing the stagnated live-QI to relieve the stagnation of QI function.

6, Flos Chrysanthemi:

Claim Flos Chrysanthemi, Flos Chrysanthemi, Flos Chrysanthemi, Flos Chrysanthemi, Flos Chrysanthemi etc. again, contain chrysanthemum glycoside, aminoacid, flavonoid and mcg vitamin B1 main the branch.Have functions such as wind and heat dispersing, liver heat removing and eyesight improving, blood pressure lowering.

7, Flos Lonicerae:

Claim Flos Lonicerae, Flos Lonicerae, little egret flower, Soviet Union's flower, JINHUA etc. again; The main component flower contains luteolin, inositol and Saponin, tannin etc.Flos Lonicerae contains luteolin, inositol and volatile oil.Main constituent is Flos Lonicerae alcohol and linalool in the volatile oil.Have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior heat clearing away, antiinflammatory etc.

8, Cortex Moutan:

Another name Cortex Moutan, unpeeled CORTEX MOUTAN, wooden Radix Paeoniae, bar Cortex Moutan, Luoyang flower are the root bark of Ranunculaceae Paeonia plant Paeonia suffruticosa.Be used as medicine with root bark.Effect with clearing away heat and cooling blood, promoting blood circulation to remove blood stasis cures mainly calentura and spits blood, epistaxis, and the heat in blood macule, acute appendicitis, dysmenorrhea due to blood stasis, amenorrhea stomachache, the traumatic injury blood stasis is had a pain, hypertension, neurodermatitis, allergic rhinitis.

9, Cortex Acanthopancis:

Claim CORTEX ACANTHOPANACIS again; Main component contains tannin, Palmic acid, linolenic acid and vitamin A, B1, and lignan's compositions such as single glycoside of sesamin, Savinin, syringaresinol and two glycosides also contain daucosterol, cardiotonic glycoside and Saponin etc.Cure mainly anemofrigid-damp arthralgia, the muscles and bones contraction is anxious, traumatic injury impairment caused by overstrain, waist knee joint weakness, sexual impotence.Disease with wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, only numb pain.

10, Rhizoma Atractylodis:

Call red art, horse Ji, blue or green art, thatch art, magic arts etc., be the root of feverfew; Function: spleen invigorating, dampness, resolving depression is warded off dirty.Cure mainly: control wet the Sheng and be stranded spleen, the asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting is had loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.

11, Rhizoma Gastrodiae:

Claim again yellow moccasin flower, RHIZONA GASTRODIAE, water Rhizoma Solani tuber osi, winter Peng etc.; Main component contains vanillyl alcohol, vanillin, retinoid material, glycoside, crystallinity neutral substance and gastrodin, p-Hydroxybenzylalcohol, Pai Lixin, Rhizoma Gastrodiae ether glycoside etc.Cure mainly and control dizzy pupil, the wind syndrome of head headache, numb limbs and tense tendons, hemiplegia, aphasia, children's startles wind.Have endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, wind-expelling pain-stopping.

12, Radix Angelicae Sinensis:

Claim dried returning again; Main component contains volatile oil, contains Palmic acid, stearic acid, myristic acid and unsaturated oleic acid, linoleic acid; In the not saponification composition cupreol is arranged.Have tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation, energy coronary dilating, antiinflammatory action, the bronchial smooth muscle that can relax has hepatoprotective effect

13, Fructus Corni:

Claim another name for Sichuan Province Fructus Jujubae, reality, Fructus Corni, real Fructus Jujubae, meat Fructus Jujubae, medicine Fructus Jujubae etc. again, main component contains cornin, Saponin, tannin, ursolic acid, gallic acid, malic acid, tartaric acid and vitamin A; Palmic acid, oleic acid and linoleic acid etc. are arranged in the fatty oil of seed.Have liver and kidney tonifying, convergence astringent or styptic treatment for spontaneous sweating, hidroschesis, the merit of hemostasis arranged.

14, the Cortex Eucommiae:

Claim to think celestial being again, think the second month in a season, pull a skin, silk flosssilk wadding skin;

Cure mainly the spinal column ache, a little less than the limbs flaccidity, seminal emission, spermatorrhea is had loose bowels just before dawn, asthenia, dribbling urination, hypertension.Has invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering.

15, Radix Morindae Officinalis:

Title clings to halberd, Intestinum Gallus domesticus wind, rabbit intestinal, three MANCAO again, grass does not wither;

Main component contains vitamin C and saccharide.Disease with reinforcing the kidney and supporting YANG benefit essence, expelling wind and removing dampness, treating the liver, kidney two void.

16, Herba Epimedii:

Have another name called: Herba Epimedii, Herba Epimedii, abandon cane grass, thousand liang of gold, dried chicken muscle, three furculas, Herba Saniculae lamelligerae etc.,

Main component: contain icariine, leaf still contains volatile oil, ceryl alcohol, 1 alkane, plant sterol, tannin, oils and fats.Fatty acid in the fatty oil has Palmic acid, stearic acid, oleic acid, linoleic acid.

Have kidney invigorating and YANG supporting, expelling wind and removing dampness, can control anemofrigid-damp arthralgia, pain in the lumbar region limb fiber crops.

17, Poria:

Claim Fu Tu, Poria, Fu Ling, volt Tu, loose potato, Song Ling etc. again; The main component sclerotium contains B-pachyman and triterpenoid compound acetyl pachymic acid, pachymic acid, 3B-hydroxyl Pilus Caprae seu Ovis steroid trienic acid.

Have. promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing.

18, Radix Puerariae:

Claim RADIX PUERARIAE, Pachyrhizua angulatus, Radix puerariae, Radix Puerariae etc. again, main component contains multiple flavones ingredient, and main active is big legumin, daidzin, puerarin, puerarin-7-xyloside etc.Have expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, antidiarrheal, expansible brain coronary artery.

19, Fructus Crataegi:

Claim red pawl reality, Chinese bush cherry, red Chinese date, Fructus Pyri Pashiae fruit, Ziziphi Spinosae etc. again, main component: contain citric acid, malic acid, Crataegolic acid, tannin, Saponin, fructose, vitamin C, protein and fat etc.Have promoting digestion and removing stagnation, blood circulation promoting and blood stasis dispelling, can control hernia swelling and hanging down of either of the testes distending pain and angina pectoris, hypertension, hyperlipidemia etc.

20, Radix Salviae Miltiorrhizae:

Claim Radix Salviae Miltiorrhizae again, fry Radix Salviae Miltiorrhizae; Main component contains crystallinity furo phenanthrenequione class pigment, and main is TANSHINONES 1A, IIB, cryptotanshinone, and the quinones pigment that dihydroisotanshinone I and multiple content are less is as the hydroxyl TANSHINONES; Iso tanshinone I, II, different cryptotanshinone, miltirone etc.; Other contains danshensu, carnosol, phenols branches such as protocatechualdehyde.In addition, contain vitamin E, B one sitosterol, steroid derivative tigogenin etc.Has the effect that blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, relieving restlessness are calmed the nerves.

21, the Radix Astragali:

Claim hundred, Rhizoma Paridis tetraphyllae, the arrow stilbene only son and heir, two people to lift etc. again; Main component contains sucrose, glucuronic acid, phlegmatic temperament, several aminoacid, bitter principle, choline, betanin, folic acid, tells 2 ', 4 '-dihydroxy-5 again, 6-dimethoxy isoflavan and kumatakenin.Cure mainly: control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and do not hold back for a long time.Have invigorating the spleen and replenishing QI, strengthening superficial resistance to stop perspiration, benefiting qi and raising yang, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, the treatment prostate hyperplasia, urine retention, surgery ulcer, bad, the edema of hematopoietic function, hypertension, apoplexy retreat that disease, metrorrhagia are lost blood, diabetes etc.

22, structure Fructus Lycii:

Claim Gou Qizi, FRUCTUS LYCII, red ear pendant, Chinese holly ground bud, blood Fructus Lycii etc. again;

Main component contains carotene, thiamine, riboflavin, Yan acid, ascorbic acid, β-sitosterol, linoleic acid etc.Cure mainly hepatic and renal YIN deficiency, nourishing the liver and kidney makes eye bright, lung moistening.

23, Caulis Spatholobi:

Claim CAULIS SPATHOLOBI, blood joint rattan again; Main component contains catechol tannin, reducing sugar, resinene, volatile oil and steroid substances.Curing mainly enriches blood invigorates blood circulation relaxing muscles and tendons and activating QI and blood in the collateral.

24, Radix Rehmanniae Preparata:

Claim Radix Rehmanniae Preparata, big Radix Rehmanniae Preparata again, fry ground, two ground, nine prepared glutinous rehmannias, cherish Radix Rehmanniae Preparata etc.;

Main component: contain Rehmannioside A, B, C, D, dihydro Catalpin, aucubin, Catalpin, Catalpin.Still contain cupreol, mannitol, daucosterol, 1-ethyl-β-D-galactoside and sucrose in the bright root ethanol extract.Have enrich blood, YIN nourishing, vital essence replenishing and marrow benifiting, invigorating the liver and kidney.

25, Semen Ziziphi Spinosae:

Main component contains jujuboside A, B, contains the acid of birch skin, birch skin alcohol and volume fatty oil, protein etc. in addition.Feeble QI, sour in the mouth.

Function cures mainly: nourish heart, easing the affected liver is calmed the nerves, arresting sweating.Be used for restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, diseases such as sweating due to debility excessive thirst.

26, Rhizoma Dioscoreae:

Claim Rhizoma Dioscoreae, youngster's grass, Rhizoma Dioscoreae, Rhizoma dioscoreae, Serpentis taro, wild sweet potato etc. again;

Main component contains Saponin, phlegmatic temperament, choline, starch, glycoprotein and free amino acid, also contains only wooden fork element, polyphenol oxidase, vitamin C, 3,4-dihydroxy benzenes ethamine, mannan and phytic acid.Function cures mainly diarrhea due to hypofunction of the spleen, chronic dysentery, and cough due to consumptive disease is quenched one's thirst, frequent micturition.Have strengthen the spleen and stomach, lung benefiting nourishing kidney, weakness of the spleen and stomach, chronic nephritis, diabetes, dysphoria with smothery sensation are thirsty.

27, Rhizoma Polygonati:

Claim Herba Polygoni Capitati, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Zingiberis Recens, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Rhizoma Polygonati etc. again;

Main mucous matter, starch, sugar, Yan acid quinones.

Function cures mainly: control deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones weakness, rheumatalgia, wind favus disease.Have lung moistening YIN nourishing, invigorating the spleen and replenishing QI, the kidney invigorating and essence nourishing, can treat tinea pedis, low blood pressure, myopia, weakness of the spleen and stomach, fatigue and asthenia, angina pectoris, etc.

28, Radix Polygoni Multiflori Preparata:

Have another name called Radix Polygoni Multiflori, Herba Stellariae Saxatilis, be the dried root of polygonum multiflorum thunb.Radix Polygoni Multiflori Preparata has the function of invigorating the liver and kidney, benefiting essence-blood, strengthening bone and muscle, is used for diseases such as dizziness and tinnitus, early whitening of hair, soreness of waist and knee joint, numb limbs and tense tendons, hyperlipidemia.

The present invention makes full use of the effect that aforementioned pharmaceutical compositions supplements and complements each other according to Chinese medical theory, reaches heat-clearing and toxic substances removing, evil-wind expelling and dampness removing, blood circulation promoting and blood stasis dispelling, dredging the meridian, anti-inflammatory analgetic jointly, and Yin Yang balancing improves immunity and strengthens resistance against diseases.

Compared with the prior art, the present invention not only simple, the pure Chinese medicinal preparation of preparation technology, have no side effect, and have curative effect short, expand blood vessel, suppress platelet aggregation, prevent atherosclerosis.

The specific embodiment

The invention will be further described below in conjunction with embodiment.

Embodiment 1

The present invention carries out selection, weighs by following 28 kinds of Chinese herbal medicine:

Radix Saposhnikoviae 10 grams, Radix Notoginseng 10 grams, Radix Ginseng 10 grams, Fructus Schisandrae Chinensis 10 grams, Radix Bupleuri 15 grams, Flos Chrysanthemi 15 grams, Flos Lonicerae 15 grams, Cortex Moutan 15 grams, Cortex Acanthopancis 15 grams, Rhizoma Atractylodis 15 grams, Rhizoma Gastrodiae 15 grams, Radix Angelicae Sinensis 15 grams, Fructus Corni 15 grams, the Cortex Eucommiae 15 grams, Radix Morindae Officinalis 15 grams, Herba Epimedii 15 grams, Poria 20 grams, Radix Puerariae 20 grams, Fructus Crataegi 20 grams, Radix Salviae Miltiorrhizae 20 grams, the Radix Astragali 20 grams, Fructus Lycii 20 grams, Caulis Spatholobi 20 grams, Radix Rehmanniae Preparata 20 grams, Semen Ziziphi Spinosae 30 grams, Rhizoma Dioscoreae 30 grams, Rhizoma Polygonati 30 grams, Radix Polygoni Multiflori Preparata 30 grams.After weighing, carry out roguing work, carry out the distilled water proportioning according to 1: 8 multiple proportions example of Chinese herbal medicine gross weight 500 grams then, promptly add the distilled water of 4000 grams with 20 mesh sieves.Admixing medical solutions is put into immersion post-heating half an hour in the boiling container.After temperature is controlled at 115 degree for the first time, left standstill 1 hour; Carry out the heating second time again, temperature reaches 100 degree, leaves standstill again; So digestion process is through 2～3 times, total more than 6 hour heat time heating time, and this invention Chinese herbal medicine gross weight is 1: 5 with the ratio of distilled water, when being brownish red, leaves standstill clear liquor at normal temperatures 8 hours.Filter the extraction supernatant with the macromolecular filter membrane machine, according to every bottle of 500 milliliters of medicinal liquids bottling.When taking, sooner or later respectively obey each 20～40 milliliters 1 time.

Embodiment 2

The present invention carries out selection, weighs by following 28 kinds of Chinese herbal medicine:

Radix Saposhnikoviae 5 gram, Radix Notoginseng 5 grams, Radix Ginseng 5 grams, Fructus Schisandrae Chinensis 5 grams, Radix Bupleuri 10 grams, Flos Chrysanthemi 10 grams, Flos Lonicerae 10 grams, Cortex Moutan 10 grams, Cortex Acanthopancis 10 grams, Rhizoma Atractylodis 10 grams, Rhizoma Gastrodiae 10 grams, Radix Angelicae Sinensis 10 grams, Fructus Corni 10 grams, the Cortex Eucommiae 10 grams, Radix Morindae Officinalis 10 grams, Herba Epimedii 10 grams, Poria 15 grams, Radix Puerariae 15 grams, Fructus Crataegi 15 grams, Radix Salviae Miltiorrhizae 15 grams, the Radix Astragali 15 grams, Fructus Lycii 15 grams, Caulis Spatholobi 15 grams, Radix Rehmanniae Preparata 15 grams, Semen Ziziphi Spinosae 25 grams, Rhizoma Dioscoreae 25 gram, Rhizoma Polygonati 25 gram, Radix Polygoni Multiflori Preparata 25 gram.After weighing, carry out roguing work, carry out the distilled water proportioning according to the 1:8 multiple proportions example of Chinese herbal medicine gross weight 360 grams then, promptly add the distilled water of 2880 grams with 20 mesh sieves.Admixing medical solutions is put into immersion post-heating half an hour in the boiling container.After temperature is controlled at 115 degree for the first time, left standstill 1 hour; Carry out the heating second time again, temperature reaches 100 degree, leaves standstill again; So digestion process is through 2～3 times, and total more than 6 hour heat time heating time, this invention Chinese herbal medicine gross weight is 1:5 with the ratio of distilled water, when being brownish red, leaves standstill clear liquor at normal temperatures 9 hours.Filter the extraction supernatant with the macromolecular filter membrane machine, according to every bottle of 500 milliliters of medicinal liquids bottling.。When taking, sooner or later respectively obey each 20～40 milliliters 1 time.

Embodiment 3

The present invention carries out selection, weighs by following 28 kinds of Chinese herbal medicine:

Radix Saposhnikoviae 15 grams, Radix Notoginseng 15 grams, Radix Ginseng 15 grams, Fructus Schisandrae Chinensis 15 grams, Radix Bupleuri 20 grams, Flos Chrysanthemi 20 grams, Flos Lonicerae 20 grams, Cortex Moutan 20 grams, Cortex Acanthopancis 20 grams, Rhizoma Atractylodis 20 grams, Rhizoma Gastrodiae 20 grams, Radix Angelicae Sinensis 20 grams, Fructus Corni 20 grams, the Cortex Eucommiae 20 grams, Radix Morindae Officinalis 20 grams, Herba Epimedii 20 grams, Poria 25 grams, Radix Puerariae 25 grams, Fructus Crataegi 25 grams, Radix Salviae Miltiorrhizae 25 grams, the Radix Astragali 25 grams, structure Fructus Lycii 25 grams, Caulis Spatholobi 25 grams, Radix Rehmanniae Preparata 25 grams, Semen Ziziphi Spinosae 35 grams, Rhizoma Dioscoreae 35 grams, Rhizoma Polygonati 35 grams, Radix Polygoni Multiflori Preparata 35 grams.After weighing, carry out roguing work, carry out the distilled water proportioning according to the 1:8 multiple proportions example of Chinese herbal medicine gross weight 640 grams then, promptly add the distilled water of 5120 grams with 20 mesh sieves.Admixing medical solutions is put into immersion post-heating half an hour in the boiling container.After temperature is controlled at 115 degree for the first time, left standstill 1 hour; Carry out the heating second time again, temperature reaches 100 degree, leaves standstill again; So digestion process is through 2～3 times, and total more than 6 hour heat time heating time, this invention Chinese herbal medicine gross weight is 1: 5 with the ratio of distilled water, when being brownish red, leaves standstill clear liquor at normal temperatures 10 hours.Filter the extraction supernatant with the macromolecular filter membrane machine, according to every bottle of 500 milliliters of medicinal liquids bottling.。When taking, sooner or later respectively obey each 20～40 milliliters 1 time.

One, acute toxicity testing:

Chinese medicine oral liquid content of dispersion of the present invention is 0.2 grams per milliliter, one day 2 times, each 20 milliliters～40 milliliters sooner or later, average every day, pharmaceutical quantities was about 12 gram/crude drugs/people/sky.

Get 12 of healthy home mouse, every about 30～50 grams divide two groups, 6 of every group of home mouse at random.By 60 gram/kilogram oral liquids and 120 gram/kilogram oral liquid administrations, irritate and feed oral liquid of the present invention respectively.After 7 days, all none death of home mouse.Through anatomic observation, each internal organs tubing form does not have any unusual, illustrates that the present invention has certain safety.

Two, clinical experiment:

Be the property of medicine that explanation drug port of the present invention is taken medicine, choose 100 routine patients immediately and divide into groups to test treatment group (A group) 50 examples, matched group (B group) 50 examples.Wherein A organizes: male 35 examples, women 15 examples, 46～70 years old age, average 63.55 ± 5.74 years old; B group: male 42 examples, women 8 examples, 45～71 years old age, average 62.50 ± 8.17 years old.Treatment group (A group) adopts drug port of the present invention to take medicine, every day 2 times sooner or later, each 20ml～40ml; And matched group (B group) adopts each 6 of XIAOSHUAN TONGLUO PIAN, every day 3 times.Equal oral meal, testing the course of treatment is 15 days.During the treatment, the related drugs of the various cardiovascular and cerebrovascular vessel of stopping using.

1, the apoplexy at acute stage clinical efficacy relatively: see Table 1.

Table 1 apoplexy at acute stage clinical efficacy relatively

? n

Recovery from illness

Produce effects

Effectively

Invalid

Total effective rate

Total obvious effective rate

					(％)	(％)
							The A group	50	7	13	4	92.45	67.92
The B group	50	3	19	4	92.00	54.00

Analyze through Ridit: two groups of total effective rates do not have significant difference (P〉0.05), and total obvious effective rate A group is better than B group (P＜0.01)

2, to the influence of blood fat: see Table 2.

The variation of blood fat before and after table 2 treatment (X ± S)

The t check: (A group) be triglyceride reducing and cholesterol (P＜0.01) obviously, and XIAOSHUAN TONGLUO PIAN (B group) does not all have this effect.

3, to hemorheological influence: see Table 3.

Hemorheological variation before and after table 3 treatment (X ± S)

As seen from the above table: two groups can be reduced effectively all that whole blood is high and low cuts viscosity and plasma viscosity, and the A group slightly is better than the B group.

4, treat the variation of suffering from acute stroke: see Table 4 to head CT.

The change (peripheral edema band) of head CT when table 4 brain bolt extensively treating is treated apoplexy

CT contrast before and after the treatment: show that hemorrhagic focus all obviously absorbs, peripheral edema also is clearly better, and the occupy-place effect all disappears, and for cerebral infarction, infarct size is not seen obviously and dwindled before and after the treatment, but the peripheral edema band all obviously alleviates.Two groups of peripheral edema bands all take an evident turn for the better, through X 2 test there was no significant difference (P〉0.05).

5, the influence of blood aggregation:

Select the patient of 72 routine hyperviscosity syndromes, after the present invention's treatment, the variation of blood aggregation.See Table 5

The comparison of table 5 blood aggregation (x ± s)

	The example number	Erythrocyte aggregation index	Platelet adhesion rate (%)	Erythrocyte sedimentation rate (mm/l)	ESR equation K value
						Before the treatment	72	2.29±0.27	73.48±3.46	25±12.6	157±26.9
After the treatment	72	1.90±0.26	59.68±2.76	24±11.8	136±21.6
						The P value		<0.01	<0.01	<0.05	<0.01

Data shows: the patient of 72 routine hyperviscosity syndromes, after the present invention's treatment, full erythrocyte aggregation index, number of platelets, with relatively there were significant differences (P＜0.01) before the treatment, and erythrocyte sedimentation rate changes not obvious (P＜0.05), as seen the present invention can reduce dense consistence, aggregation and the viscosity of blood by a plurality of links, eliminates the danger of blood-hyperviscosity state, can be used for the prevention and the treatment of ischemic cardiovascular and cerebrovascular disease.

Case 1:

Liu Yuzhen, woman, 54 years old;

On October 8th, 1985 suffered from hypertension, coronary heart disease several years when going to a doctor, and it is all invalid to take medicine for a long time, have an injection.By taking Chinese medicine oral liquid of the present invention, according to sooner or later respectively obeying 40 milliliters every day, warm water is taken after mixing it with water.After two treatments 30 days courses of treatment, hypertension, coronary heart disease all disappear, and do not see recurrence so far.

Case 2:

Zhang Yuankui, man, 53 years old;

On July 12nd, 1997 was admitted to hospital a few days ago, and is uncomfortable in chest because of overworking, dizziness is weak, the heart is uncomfortable, day outbreak 2～3 times.The back electrocardiogram of being admitted to hospital shows that acute myocardial ischemia is diagnosed as angina pectoris.Take Chinese medicine oral liquid of the present invention, according to sooner or later respectively obeying 40 milliliters every day, transference cure after oral 3 days, continue to take 15 days courses of treatment after, electrocardiogram is normal, recovery from illness.

Case 3:

Guo Song, the man, 39 years old,

When December was gone to a doctor on the 20th in 2000, nervous uncomfortable in chest, half wheat harvesting period of breathing hard was taken one week of XIAOSHUAN TONGLUO PIAN, and curative effect does not show.After diagnosing, coronary disease pain fatigue angina pectoris.By taking Chinese medicine oral liquid of the present invention, according to sooner or later respectively obeying 40 milliliters every day, sx after oral 3 days, continue to take 15 days courses of treatment after, the index of blood fat, cholesterol, triglyceride, lipoprotein is all normal, recovery from illness.

Claims (2)

1, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease is characterized in that according to the percentage by weight crude drug being:

Radix Saposhnikoviae 1%～3%, Radix Notoginseng 1%～3%, Radix Ginseng 1%～3%, Fructus Schisandrae Chinensis 1%～3%, Radix Bupleuri 2%～4%, Flos Chrysanthemi 2%～4%, Flos Lonicerae 2%～4%, Cortex Moutan 2%～4%, Cortex Acanthopancis 2%～4%, Rhizoma Atractylodis 2%～4%, Rhizoma Gastrodiae 2%～4%, Radix Angelicae Sinensis 2%～4%, Fructus Corni 2%～4%, the Cortex Eucommiae 2%～4%, Radix Morindae Officinalis 2%～4%, Herba Epimedii 2%～4%, Poria 3%～5%, Radix Puerariae 3%～5%, Fructus Crataegi 3%～5%, Radix Salviae Miltiorrhizae 3%～5%, the Radix Astragali 3%～5%, Fructus Lycii 3%～5%, Caulis Spatholobi 3%～5%, Radix Rehmanniae Preparata 3%～5%, Semen Ziziphi Spinosae 5%～7%, Rhizoma Dioscoreae 5%～7%, Rhizoma Polygonati 5%～7%, Radix Polygoni Multiflori Preparata 5%～7%.

2, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease according to claim 1 is characterized in that according to the percentage by weight crude drug being:

Radix Saposhnikoviae 2%, Radix Notoginseng 2%, Radix Ginseng 2%, Fructus Schisandrae Chinensis 2%, Radix Bupleuri 3%, Flos Chrysanthemi 3%, Flos Lonicerae 3%, Cortex Moutan 3%, Cortex Acanthopancis 3%, Rhizoma Atractylodis 3%, Rhizoma Gastrodiae 3%, Radix Angelicae Sinensis 3%, Fructus Corni 3%, the Cortex Eucommiae 3%, Radix Morindae Officinalis 3%, Herba Epimedii 3%, Poria 4%, Radix Puerariae 4%, Fructus Crataegi 4%, Radix Salviae Miltiorrhizae 4%, the Radix Astragali 4%, Fructus Lycii 4%, Caulis Spatholobi 4%, Radix Rehmanniae Preparata 4%, Semen Ziziphi Spinosae 6%, Rhizoma Dioscoreae 6%, Rhizoma Polygonati 6%, Radix Polygoni Multiflori Preparata 6%.