CN103285278A - Medicament for preventing and treating ischemic cerebral apoplexy and preparation method thereof - Google Patents
Medicament for preventing and treating ischemic cerebral apoplexy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicament for preventing and treating ischemic cerebral apoplexy and a preparation method thereof. The preparation method comprises the following steps of: adding water into the drugs including peach seeds, safflower, medicinal cyathula roots, angelica sinensis, eucommia ulmoides, radix astragali, wolfberry fruits, prepared fleece flower roots, albizia flowers, rhizoma gastrodiae, rhizoma gastrodiae, polygala tenuifolia, platycladi seeds and long-noded pit viper, and decocting the mixture twice and two hours respectively; mixing filtrates, filtering the filtrate, and concentrating the filtrate to obtain a thick paste with the relative density of 1.35-1.40; crushing three traditional Chinese medicines including musk, Chinese yam and coix seed into fine powder, screening the fine powder and uniformly mixing the fine powder; uniformly mixing the thick paste and the fine powder; placing the mixture into an oven; drying the mixture at the temperature below 60 DEG C, so that the water content is lower than 6%; discharging; cooling the mixture to room temperature, then crushing the mixture into fine powder of 80-140 meshes, and weighing; adding glycerol and azone respectively accounting for 1% of the fine power, and vaseline and wool grease respectively accounting for 50%-100% of the fine power into the fine power; stirring the substances into a paste at the temperature of 60-80 DEG C; forming by pressing the paste; cooling a formed product; adhering the formed product to an adhesive tape; packaging to obtain a product. The medicament is low in cost, convenient to use and remarkable in curative effect for preventing and treating ischemic cerebral apoplexy, and has no toxic or side effects and does not need oral administration.
Description
Technical field
The present invention relates to the medicine of a kind of prevention and treatment ischemia apoplexy, particularly a kind of is the prevention of crude drug preparation and the medicine for the treatment of ischemia apoplexy with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Ischemia apoplexy is a kind of commonly encountered diseases, just refers to cerebrovascular stenosis or obturation, causes cerebral blood flow blocking-up and makes cerebral tissue generation hypoxic-ischemic, softening even downright bad, causes the cerebrovascular function obstacle, causes related symptoms.Ischemia apoplexy, cerebral thrombosis, cerebral embolism, lacuna ischemia apoplexy and multiple ischemia apoplexy and transient apoplexy all belong to ischemia apoplexy, and ischemia apoplexy is the main type of cerebrovascular disease, and about 85% apoplexy is ischemic.Be main clinical manifestation with the hemiplegia, often accompany by facial hemiparalysis, slurred speech.Clinical common patient causes ischemia apoplexy because medical histories such as hypertension, hyperlipidemia, diabetes are arranged self.At present, clinically prevention and the treatment of ischemia apoplexy still there is not especially effectively medicine.Existing Therapeutic Method commonly used has supporting treatment, recovers ischemic region perfusion and neurocyte protection Drug therapy.Also can only play the effect of blood vessel dilating, alleviation disease, poor effect.
Summary of the invention
The purpose of this invention is to provide the medicine of a kind of prevention and treatment ischemia apoplexy, natural pure, the safety non-toxic of this medicine does not have dependency, is free from side effects.
The preparation method that this medicine is provided in addition is another object of the present invention.
Contained drug is that crude drug prepares by following parts by weight of traditional Chinese medicines among the present invention:
Semen Persicae 1-30 Flos Carthami 10-30 Moschus 5-15
Radix Cyathulae 30-90 Rhizoma Dioscoreae 30-90 Radix Angelicae Sinensis 20-60
Cortex Eucommiae 20-60 Radix Astragali 60-180 Semen Coicis 20-60
Fructus Lycii 20-60 Radix Polygoni Multiflori Preparata 30-90 Flos Albiziae 10-30
Rhizoma Gastrodiae 10-30 Rhizoma Chuanxiong 10-30 Radix Polygalae 10-30
Semen Platycladi 10-30 Agkistrodon 10-30.
The preferred parts by weight proportioning of the present invention is:
Semen Persicae 20, Flos Carthami 20, Moschus 10, Radix Cyathulae 60, Rhizoma Dioscoreae 60, Radix Angelicae Sinensis 40, the Cortex Eucommiae 40, the Radix Astragali 120, Semen Coicis 40, Fructus Lycii 40, Radix Polygoni Multiflori Preparata 60, Flos Albiziae 20, Rhizoma Gastrodiae 20, Rhizoma Chuanxiong 20, Radix Polygalae 20, Semen Platycladi 20, Agkistrodon 20.
Said medicine can be made on the pharmaceutics any dosage form such as tablet, pill, powder, capsule, the present invention is patch preferably.
The concrete preparation method of above-mentioned each component being made medicine of the present invention is:
With above-mentioned except Moschus, Rhizoma Dioscoreae, Semen Coicis 14 flavor Chinese medicines, decoct with water twice, each 2h, merging filtrate filters, it is 1.35～1.40 thick paste that filtrate is concentrated into relative density; Moschus, Rhizoma Dioscoreae, Semen Coicis three flavor Chinese medicine powders are broken into fine powder, sieve mixing; With above-mentioned thick paste, fine powder mixing, put into baking oven, carrying out drying below 60 ℃, water content is reached below 6%, discharging is cooled to and is ground into 80～140 purpose fine powders after the room temperature and weighs, and vaseline, the lanoline that respectively accounts for glycerol, the azone of fine powder weight 1% and account for fine powder weight 50%～100% added in the fine powder, under 60～80 ℃ condition, stir into pasty state, compression moulding, cooling sticks on the adhesive tape, packing namely gets product.
Specification: every subsides dose is 3～9 grams, and the best is 6 grams.
Using method: be affixed on umbilical part, one time one subsides, 2～3 are once.
In the prescription of the present invention, the Radix Astragali, Rhizoma Dioscoreae QI invigorating are monarch, the Fructus Lycii yin nourishing is minister, and Cortex Eucommiae invigorating the liver and kidney is minister, and the Radix Polygoni Multiflori Preparata enrich and benefit essence and blood is minister, the Rhizoma Gastrodiae suppressing the hyperactive liver and subsiding YANG is minister, Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Cyathulae are invigorated blood circulation and are that minister, Semen Coicis spleen invigorating are minister, and the Agkistrodon dispelling wind and removing obstruction in the collateral is minister, Radix Polygalae, Semen Platycladi, Flos Albiziae tranquilizing by nourishing the heart, loosening bowel to relieve constipation are assistant, and Moschus is had one's ideas straightened out and is assistant.All medicines share, and gather the effect of benefiting QI for activating blood circulation, dispelling wind and removing obstruction in the collateral, invigorating the liver and kidney, benefiting essence-blood, strengthening the body resistance altogether, hold concurrently with tranquilizing by nourishing the heart, and prevention and treatment ischemia apoplexy have special effect.
For further investigating clinical efficacy and the safety of medicine of the present invention, select 66 routine ischemia apoplexy patients that the curative effect of medicine of the present invention is carried out clinical observation.
Therapeutic effect standard of the present invention:
Cure: symptom and sign disappear, and can live on one's own life substantially.Take a turn for the better: symptom and sign take a turn for the better, the action of energy cane, or basic life can be taken care of oneself.Do not heal: symptom and sign no change.
Through treating 66 examples, cure 58 examples, 5 examples that take a turn for the better, 3 examples that do not heal, total effective rate 96 ﹪.
The present invention is with low cost, need not orally, easy to use, has no side effect, and is evident in efficacy to prevention and treatment ischemia apoplexy.
The specific embodiment
Embodiment 1: get Semen Persicae 10 kg, Flos Carthami 10 kg, Moschus 5 kg, Radix Cyathulae 30 kg, Rhizoma Dioscoreae 30 kg, Radix Angelicae Sinensis 20 kg, the Cortex Eucommiae 20 kg, the Radix Astragali 60 kg, Semen Coicis 20 kg, Fructus Lycii 20 kg, Radix Polygoni Multiflori Preparata 30 kg, Flos Albiziae 10 kg, Rhizoma Gastrodiae 10 kg, Rhizoma Chuanxiong 10 kg, Radix Polygalae 10 kg, Semen Platycladi 10 kg, 10 kg are standby for Agkistrodon; With above-mentioned except Moschus, Rhizoma Dioscoreae, Semen Coicis 14 flavor Chinese medicines, decoct with water twice, each 2h, merging filtrate filters, it is 1.35 thick paste that filtrate is concentrated into relative density; Again Moschus, Rhizoma Dioscoreae, Semen Coicis three flavor Chinese medicine powders are broken into fine powder, sieve mixing; With above-mentioned thick paste, fine powder mixing, put into baking oven, carrying out drying below 60 ℃, water content is reached below 6%, discharging is cooled to and is ground into 80 purpose fine powders after the room temperature and weighs, and vaseline, the lanoline that respectively accounts for glycerol, the azone of fine powder weight 1% and account for fine powder weight 50% added in the fine powder, under 60 ℃ condition, stir into pasty state, compression moulding, cooling sticks on the adhesive tape, packing namely gets product.
Embodiment 2: get Semen Persicae 20 kg, Flos Carthami 20 kg, Moschus 10 kg, Radix Cyathulae 60 kg, Rhizoma Dioscoreae 60 kg, Radix Angelicae Sinensis 40 kg, the Cortex Eucommiae 40 kg, the Radix Astragali 120 kg, Semen Coicis 40 kg, Fructus Lycii 40 kg, Radix Polygoni Multiflori Preparata 60 kg, Flos Albiziae 20 kg, Rhizoma Gastrodiae 20 kg, Rhizoma Chuanxiong 20 kg, Radix Polygalae 20 kg, Semen Platycladi 20 kg, 20 kg are standby for Agkistrodon; With above-mentioned except Moschus, Rhizoma Dioscoreae, Semen Coicis 14 flavor Chinese medicines, decoct with water twice, each 2h, merging filtrate filters, it is 1.38 thick paste that filtrate is concentrated into relative density; Again Moschus, Rhizoma Dioscoreae, Semen Coicis three flavor Chinese medicine powders are broken into fine powder, sieve mixing; With above-mentioned thick paste, fine powder mixing, put into baking oven, carrying out drying below 60 ℃, water content is reached below 6%, discharging is cooled to and is ground into 100 purpose fine powders after the room temperature and weighs, and vaseline, the lanoline that respectively accounts for glycerol, the azone of fine powder weight 1% and account for fine powder weight 80% added in the fine powder, under 70 ℃ condition, stir into pasty state, compression moulding, cooling sticks on the adhesive tape, packing namely gets product.
Embodiment 3: get Semen Persicae 30 kg, Flos Carthami 30 kg, Moschus 15 kg, Radix Cyathulae 90 kg, Rhizoma Dioscoreae 90 kg, Radix Angelicae Sinensis 60 kg, the Cortex Eucommiae 60 kg, the Radix Astragali 180 kg, Semen Coicis 60 kg, Fructus Lycii 60 kg, Radix Polygoni Multiflori Preparata 90 kg, Flos Albiziae 30 kg, Rhizoma Gastrodiae 30 kg, Rhizoma Chuanxiong 30 kg, Radix Polygalae 30 kg, Semen Platycladi 30 kg, 30 kg are standby for Agkistrodon; With above-mentioned except Moschus, Rhizoma Dioscoreae, Semen Coicis 14 flavor Chinese medicines, decoct with water twice, each 2h, merging filtrate filters, it is 1.4 thick paste that filtrate is concentrated into relative density; Again Moschus, Rhizoma Dioscoreae, Semen Coicis three flavor Chinese medicine powders are broken into fine powder, sieve mixing; With above-mentioned thick paste, fine powder mixing, put into baking oven, carrying out drying below 60 ℃, water content is reached below 6%, discharging is cooled to and is ground into 140 purpose fine powders after the room temperature and weighs, and vaseline, the lanoline that respectively accounts for glycerol, the azone of fine powder weight 1% and account for fine powder weight 1000% added in the fine powder, under 80 ℃ condition, stir into pasty state, compression moulding, cooling sticks on the adhesive tape, packing namely gets product.
Claims (3)
- One kind the prevention and the treatment ischemia apoplexy medicine, it is characterized in that:Be that feedstock production obtains by following parts by weight of traditional Chinese medicines:Semen Persicae 1-30 Flos Carthami 10-30 Moschus 5-15Radix Cyathulae 30-90 Rhizoma Dioscoreae 30-90 Radix Angelicae Sinensis 20-60Cortex Eucommiae 20-60 Radix Astragali 60-180 Semen Coicis 20-60Fructus Lycii 20-60 Radix Polygoni Multiflori Preparata 30-90 Flos Albiziae 10-30Rhizoma Gastrodiae 10-30 Rhizoma Chuanxiong 10-30 Radix Polygalae 10-30Semen Platycladi 10-30 Agkistrodon 10-30.
- 2. medicine of prevention according to claim 1 and treatment ischemia apoplexy and preparation method thereof is characterized in that described medicine is made patch.
- 3. the preparation method of medicine of the described prevention of claim 1 and treatment ischemia apoplexy, it is characterized in that with above-mentioned except Moschus, Rhizoma Dioscoreae, Semen Coicis 14 Chinese medicines of distinguishing the flavor of, decoct with water twice, each 2h, merging filtrate filters, and it is 1.35～1.40 thick paste that filtrate is concentrated into relative density; Moschus, Rhizoma Dioscoreae, Semen Coicis three flavor Chinese medicine powders are broken into fine powder, sieve mixing; With above-mentioned thick paste, fine powder mixing, put into baking oven, carrying out drying below 60 ℃, water content is reached below 6%, discharging is cooled to and is ground into 80～140 purpose fine powders after the room temperature and weighs, and vaseline, the lanoline that respectively accounts for glycerol, the azone of fine powder weight 1% and account for fine powder weight 50%～100% added in the fine powder, under 60～80 ℃ condition, stir into pasty state, compression moulding, cooling sticks on the adhesive tape, packing namely gets product.
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Cited By (3)
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| CN103610983A (en) * | 2013-12-04 | 2014-03-05 | 孙桂好 | Traditional Chinese medicine preparation for treating cerebral apoplexy |
| CN104758790A (en) * | 2015-04-07 | 2015-07-08 | 奚济孝 | Traditional Chinese medicine preparation for treating stroke syndrome and preparation method of traditional Chinese medicine preparation |
| JP2022105722A (en) * | 2017-06-30 | 2022-07-14 | 小林製薬株式会社 | Tablet including cinnamomi cortex |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610983A (en) * | 2013-12-04 | 2014-03-05 | 孙桂好 | Traditional Chinese medicine preparation for treating cerebral apoplexy |
| CN103610983B (en) * | 2013-12-04 | 2016-02-17 | 孙桂好 | A kind of Chinese medicine preparation for the treatment of apoplexy |
| CN104758790A (en) * | 2015-04-07 | 2015-07-08 | 奚济孝 | Traditional Chinese medicine preparation for treating stroke syndrome and preparation method of traditional Chinese medicine preparation |
| JP2022105722A (en) * | 2017-06-30 | 2022-07-14 | 小林製薬株式会社 | Tablet including cinnamomi cortex |
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Application publication date: 20130911 |