CN101966261A - Medicament for treating high blood pressure and preparation method thereof - Google Patents
Medicament for treating high blood pressure and preparation method thereof Download PDFInfo
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- CN101966261A CN101966261A CN2010105163670A CN201010516367A CN101966261A CN 101966261 A CN101966261 A CN 101966261A CN 2010105163670 A CN2010105163670 A CN 2010105163670A CN 201010516367 A CN201010516367 A CN 201010516367A CN 101966261 A CN101966261 A CN 101966261A
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Abstract
The invention discloses a medicament for treating high blood pressure and a preparation method thereof. The medicament comprises the following components in part by weight: 10 to 15 parts of ilex, 10 to 15 parts of cassia seed, 3 to 10 parts of lotus seed, 3 to 10 parts of white chrysanthemum, 10 to 20 parts of nacre, 10 to 15 parts of raw astragals, 5 to 10 parts of raw hawthorn, 10 to 15 parts of danshen root, 10 to 15 parts of kudzuvine root, 10 to 15 parts of polygonum multiflorum thunb, 10 to 15 parts of cornus fruit, 10 to 15 parts of eucommia bark, 3 to 5 parts of lotus leaves, 10 to 15 parts of medlar, 3 to 5 parts of honeysuckles and 5 to 10 parts of ginkgo leaves. The preparation method of the medicament comprises the following steps of: drying and grinding part of the traditional Chinese medicines, and sieving the powder; soaking part of the traditional Chinese medicines, decocting, filtering and concentrating; and mixing the powder and the concentrated solution, drying and grinding the mixture, sieving the mixture, and preparing the mixture into grains, tablets or capsules. The medicament has the effect of promoting blood circulation and removing blood stasis, nourishing yin and reducing blood pressure, calming liver wind, and strengthening the spleen and kidney, is used for treating symptoms, such as high blood pressure, hyperlipidemia, ischemia of heart and brain, arrhythmia, dizziness and the like, and has a unique formula, obvious curative effect and simple production process.
Description
Affiliated technical field
The invention belongs to the Chinese medicine preparation technical field, relating to a kind of is that raw material is treated hypertensive medicine and preparation method thereof with the Chinese herbal medicine.
Background technology
Hypertension is a kind of commonly encountered diseases and frequently-occurring disease, these disease serious harm people's is healthy, for a long time, western medicine and medical practitioners is treated this disease and has been obtained certain curative effect, but, the toxic and side effects of its medicine has also been brought a lot of miseries to patient, as the cough that causes after taking medicine, constipation, gastrointestinal reaction, liver function change or the like.Therefore, according to the tcm treatment according to syndrome differentiation theory, the hypertensive Chinese patent medicine of exploitation treatment just has crucial meaning.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of hypertension and preparation method thereof.
In order to achieve the above object, hypertensive medicine of a kind of treatment of the present invention and preparation method thereof, the weight proportion of its medicine is: Folium Ilicis 10～15, Semen Cassiae 10～15, Plumula Nelumbinis 3～10, Flos Chrysanthemi 3～10, Concha Margaritifera 10～20, Radix Astragali 10～15, Fructus Crataegi 5～10, Radix Salviae Miltiorrhizae 10～15, Radix Puerariae 10～15, Radix Polygoni Multiflori Preparata 10～15, Fructus Corni 10～15, the continuous Cortex Eucommiae 10～15, Folium Nelumbinis 3～5, Fructus Lycii 10～15, Flos Lonicerae 3～5, Folium Ginkgo 5～10.The dosage form of medicine is granule, tablet or capsule.
The manufacture method of medicine of the present invention is: with the Radix Puerariae drying; wearing into fine powder, to cross 100 mesh sieves standby; the water logging that adds 5～8 times of drug weight after then all the other the medicine weighings in the above-mentioned prescription being mixed was steeped 2 hours; decocting secondary (decocts 1.5 hours after-filtration for the first time and goes out medicinal liquid; the decocting that adds for the second time 4～5 times of drug weight in medicinal residues boils 1 hour after-filtration and goes out medicinal liquid); merge 2 times filtrate; being concentrated into relative density is 1.05～1.10; 10 ℃ of following cold preservations, getting supernatant reconcentration to heat survey proportion after 24 hours is 1.35～1.40, adds the Radix Puerariae fine powder; stir evenly; vacuum drying, the mill coarse powder is crossed 14 mesh sieves; granulate after the fine powder moistening; cross 14 mesh sieves, drying is mixed behind the granulate tabletting or is made granule or make capsule.
The present invention is through 500 routine clinical trials, random packet, double blinding dual analog case shows: with Drug therapy 300 examples of the present invention, be 85.6% to hypertensive cure-remarkable-effectiveness rate, total effective rate is 98.4%, following up a case by regular visits to 3 months cure-remarkable-effectiveness rates is 89.5%, and total effective rate is 98.7%, and matched group is treated 200 examples with Nifedipine sustained release tablets, to hypertensive cure-remarkable-effectiveness rate is 72.3%, total effective rate is 83.4%, and following up a case by regular visits to 3 months cure-remarkable-effectiveness rates is 68.8%, and total effective rate is 85.3%.Treatment group and matched group clinical efficacy, follow up a case by regular visits to the comparison of curative effect, medicine of the present invention obviously is better than Nifedipine sustained release tablets matched group (P＜0.01).
The invention has the beneficial effects as follows that this medicine has that blood circulation promoting and blood stasis dispelling, YIN nourishing blood pressure lowering, suppressing the hyperactive liver dispel the wind, the effect of strengthening spleen, tonifying kidney.Disease such as be used for the treatment of hypertension, hyperlipidemia, high blood viscosity, cardiac-cerebral ischemia, arrhythmia, feel dizzy.
Embodiment one:
1, wearing into fine powder after Radix Puerariae 15 dryings with weight proportion, to cross 100 mesh sieves standby.
2, Folium Ilicis 10 with weight proportion, Semen Cassiae 15, Plumula Nelumbinis 3, Flos Chrysanthemi 3, Concha Margaritifera 20, Radix Astragali 10, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 10, Radix Polygoni Multiflori Preparata 10, Fructus Corni 10, the continuous Cortex Eucommiae 10, Folium Nelumbinis 3, Fructus Lycii 10, Flos Lonicerae 3, Folium Ginkgo 5 medical materials add the water logging of 8 times of drug weight and steeped 2 hours, decocting secondary (decocts 1.5 hours after-filtration for the first time and goes out medicinal liquid, the decocting that adds for the second time 4 times of drug weight in medicinal residues boils 1 hour after-filtration and goes out medicinal liquid), merge 2 times filtrate, being concentrated into relative density is 1.05,10 ℃ of following cold preservations, getting supernatant reconcentration to heat survey proportion after 24 hours is 1.40, add the Radix Puerariae fine powder, stir evenly, vacuum drying, the mill coarse powder is crossed 14 mesh sieves, granulate after the fine powder moistening, cross 14 mesh sieves, drying, tabletting behind the mixing granulate.
Embodiment two:
1, wearing into fine powder after Radix Puerariae 10 dryings with weight proportion, to cross 100 mesh sieves standby.
2, Folium Ilicis 15 with weight proportion, Semen Cassiae 15, Plumula Nelumbinis 5, Flos Chrysanthemi 3, Concha Margaritifera 15, Radix Astragali 10, Fructus Crataegi 10, Radix Salviae Miltiorrhizae 15, Radix Polygoni Multiflori Preparata 15, Fructus Corni 15, the continuous Cortex Eucommiae 15, Folium Nelumbinis 3, Fructus Lycii 10, Flos Lonicerae 5, Folium Ginkgo 10 medical materials add the water logging of 8 times of drug weight and steeped 2 hours, decocting secondary (decocts 1.5 hours after-filtration for the first time and goes out medicinal liquid, the decocting that adds for the second time 4 times of drug weight in medicinal residues boils 1 hour after-filtration and goes out medicinal liquid), merge 2 times filtrate, being concentrated into relative density is 1.05,10 ℃ of following cold preservations, getting supernatant reconcentration to heat survey proportion after 24 hours is 1.40, add the Radix Puerariae fine powder, stir evenly, vacuum drying, the mill coarse powder is crossed 14 mesh sieves, granulate after the fine powder moistening, cross 14 mesh sieves, drying pours into capsule behind the mixing granulate.
Claims (3)
1. the hypertensive medicine of treatment is characterized in that this drug weight proportioning consists of: Folium Ilicis 10～15, Semen Cassiae 10～15, Plumula Nelumbinis 3～10, Flos Chrysanthemi 3～10, Concha Margaritifera 10～20, Radix Astragali 10～15, Fructus Crataegi 5～10, Radix Salviae Miltiorrhizae 10～15, Radix Puerariae 10～15, Radix Polygoni Multiflori Preparata 10～15, Fructus Corni 10～15, the continuous Cortex Eucommiae 10～15, Folium Nelumbinis 3～5, Fructus Lycii 10～15, Flos Lonicerae 3～5, Folium Ginkgo 5～10.
2. the hypertensive medicine of a kind of treatment according to claim 1; the manufacture method that it is characterized in that this tablet is: with the Radix Puerariae drying; wear into fine powder; it is standby to cross 100 mesh sieves; the water logging that adds 5～8 times of drug weight after then all the other the medicine weighings in the above-mentioned prescription being mixed was steeped 2 hours; decocting 1.5 hours after-filtration, to go out medicinal liquid standby, and the decocting that adds 4～5 times of drug weight again in the medicine residue boils 1 hour after-filtration and goes out medicinal liquid, merges 2 times filtrate; it is concentrated into relative density is 1.05～1.10; 10 ℃ of following cold preservations 24 hours, getting supernatant reconcentration to heat survey proportion was 1.35～1.40, adds the Radix Puerariae fine powder then; stir evenly; vacuum drying, the mill coarse powder is crossed 14 mesh sieves; granulate after the fine powder moistening; cross 14 mesh sieves, drying is mixed behind the granulate tabletting or granulation or is poured into capsule.
3. the hypertensive medicine of a kind of treatment according to claim 1, the dosage form that it is characterized in that this medicine is tablet or granule or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010516367A CN101966261B (en) | 2010-10-11 | 2010-10-11 | Medicament for treating high blood pressure and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010516367A CN101966261B (en) | 2010-10-11 | 2010-10-11 | Medicament for treating high blood pressure and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101966261A true CN101966261A (en) | 2011-02-09 |
| CN101966261B CN101966261B (en) | 2012-10-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010516367A Expired - Fee Related CN101966261B (en) | 2010-10-11 | 2010-10-11 | Medicament for treating high blood pressure and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907745A (en) * | 2012-09-20 | 2013-02-06 | 郑州瑞龙制药股份有限公司 | Solid beverage for clearing liver and decreasing lipid and preparation method of solid beverage |
| CN103828966A (en) * | 2014-03-05 | 2014-06-04 | 贵州省印江自治县梵净青茶业有限责任公司 | Health care tea |
| CN109170054A (en) * | 2018-09-28 | 2019-01-11 | 潜山梦想葛业专业合作社 | A kind of antihypertensive health care kudzu root tea and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536809A (en) * | 2013-11-10 | 2014-01-29 | 李艳琴 | Traditional Chinese medicine preparation for treating hypertension and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113156A (en) * | 1995-02-13 | 1995-12-13 | 张家祥 | Liquid hypotensor with cephalocatharic function |
| CN101595927A (en) * | 2008-06-06 | 2009-12-09 | 刘泳宏 | A kind of natural lung-nourishing lipopenicillinase, hypoglycemic, blood-pressure decreasing tea and preparation method |
-
2010
- 2010-10-11 CN CN201010516367A patent/CN101966261B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113156A (en) * | 1995-02-13 | 1995-12-13 | 张家祥 | Liquid hypotensor with cephalocatharic function |
| CN101595927A (en) * | 2008-06-06 | 2009-12-09 | 刘泳宏 | A kind of natural lung-nourishing lipopenicillinase, hypoglycemic, blood-pressure decreasing tea and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 《南方护理杂志》 19940831 郝蕾 高血压的食疗方 50 1－3 , 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907745A (en) * | 2012-09-20 | 2013-02-06 | 郑州瑞龙制药股份有限公司 | Solid beverage for clearing liver and decreasing lipid and preparation method of solid beverage |
| CN103828966A (en) * | 2014-03-05 | 2014-06-04 | 贵州省印江自治县梵净青茶业有限责任公司 | Health care tea |
| CN109170054A (en) * | 2018-09-28 | 2019-01-11 | 潜山梦想葛业专业合作社 | A kind of antihypertensive health care kudzu root tea and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101966261B (en) | 2012-10-24 |
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| C06 | Publication | ||
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
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Inventor after: Liang Ying Inventor before: Wang Wei |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20171016 Address after: Wu Village town 238051 administrative villages in south of the Five Ridges city of Chaohu province Anhui screen Patentee after: Liang Ying Address before: 225300 Jiangsu Province, Taizhou City Hailing District eight Bridge Street 3 building 503 room Patentee before: Wang Wei |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121024 Termination date: 20171011 |