CN104435597A - Medicine for treating habitual constipation and preparation method thereof - Google Patents

Medicine for treating habitual constipation and preparation method thereof Download PDF

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Publication number
CN104435597A
CN104435597A CN201410628618.2A CN201410628618A CN104435597A CN 104435597 A CN104435597 A CN 104435597A CN 201410628618 A CN201410628618 A CN 201410628618A CN 104435597 A CN104435597 A CN 104435597A
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radix
medicine
rhizoma rhei
treatment
habitual constipation
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连小旺
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention relates to a medicine for treating habitual constipation and a preparation method thereof. The medicine is characterized by being prepared from the following steps: firstly, grinding nine fold processed rheum officinale, raw rheum officinale and prepared pinellia ternate into fine powder and mixing for later use; then, adding water to soak trichosanthes peel, allium macrostemon, magnolia obavata, waterlife octozin, fructus aurantii, oysters, platycodon grandiflorum, burdockseeds, almonds, angelica sinensis, scutellaria baicalensis, saponin and semen brassicae, wherein water level is higher than the medicinal materials; after soaking for 48h, putting into a medicine decocting machine, decocting for 2 hours by a soft fire; taking out filtrate; then decocting and concentrating into paste; adding rheum officinale and pinellia ternate powder and making water-honeyed pills with honey; and packing to obtain a finished product. The medicine provided by the invention is good in curative effect, short in treatment course and free of toxic and side effects. The required medicinal materials are easily available, and the medicine is low in cost and remarkable in treatment effect on habitual constipation.

Description

A kind of medicine for the treatment of habitual constipation and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of habitual constipation, particularly a kind of take Chinese medicine as the Chinese medicine for the treatment of habitual constipation prepared by crude drug.The invention still further relates to the preparation method of this medicine.
Background technology
Habitual constipation is one of common disease clinically, and its risk factor is a lot.Motherland's medical science thinks QI and blood deficiency; Vehement in dryness-fire; Intestinal juice lacks; Impairment of dispersing and descending function of the lung; Deficiency of QI in middle-JIAO; The reasons such as failure of stomach-QI to descend cause.The medicine of current treatment constipation is a lot, can be divided into Chinese medicine and Western medicine generally.Western medicine is loosening bowel to relieve constipation mainly, as phenolphthalein tablets, and phenolphthalein tablet etc.So it cannot remove root.Also have Chinese medicine preparation in addition, but effect can not be satisfactory mostly.
Summary of the invention
The object of this invention is to provide a kind of therapeutic effect good, short treating period, have no side effect, the medicine of the treatment constipation that treatment cost is low.Medicine required for the present invention is drawn materials extensively, with low cost, treatment habitual constipation Be very effective.The preparation method of this medicine is provided to be another object of the present invention in addition.
Medicine of the present invention is that crude drug prepares by the Chinese medicine of following parts by weight:
Pericarpium Trichosanthis 30-60 Bulbus Allii Macrostemonis 60-90 Cortex Magnoliae Officinalis 10-15
DABAIPIAN 10-15 Fructus Aurantii 10-15 Radix Scutellariae 10-30
Concha Ostreae 20-30 Radix Platycodonis 10-15 Fructus Arctii 10-15
Semen Armeniacae Amarum 10-15 Radix Angelicae Sinensis 20-30 Rhizoma Pinelliae Preparata 10-20
Semen Sinapis Albae 15-20 Fructus Gleditsia 15-20 nine Radix et Rhizoma Rhei (processed) 10-15
Radix Et Rhizoma Rhei 15-20.
The preferred parts by weight proportioning of the present invention is:
Pericarpium Trichosanthis 45, Bulbus Allii Macrostemonis 75, Cortex Magnoliae Officinalis 18, DABAIPIAN 13, Fructus Aurantii 13, Radix Scutellariae 20, Concha Ostreae 25, Radix Platycodonis 12, Fructus Arctii 12, Semen Armeniacae Amarum 13, Radix Angelicae Sinensis 25, Rhizoma Pinelliae Preparata 15, Semen Sinapis Albae 16, Fructus Gleditsia 18, nine Radix et Rhizoma Rhei (processed) 15, Radix Et Rhizoma Rhei 18.
Said medicine can be made on pharmaceutics that any one dosage form is as tablet, powder, capsule, the present invention is water-honeyed pill preferably.
The concrete preparation method above-mentioned each component being made water-honeyed pill of the present invention is:
First nine Radix et Rhizoma Rhei (processed), Radix Et Rhizoma Rhei, Rhizoma Pinelliae Preparata are ground as smalls mixing for standby use, again by Pericarpium Trichosanthis, Bulbus Allii Macrostemonis, Cortex Magnoliae Officinalis, DABAIPIAN, Fructus Aurantii, Concha Ostreae, Radix Platycodonis, Fructus Arctii, Semen Armeniacae Amarum, Radix Angelicae Sinensis, Radix Scutellariae, Fructus Gleditsia, Semen Sinapis Albae, soak, water crosses powder, puts into boiling machine after 48 hours, slow fire boiling 2 hours, take out filtrate, decocting and concentrating becomes cream again, adds Radix Et Rhizoma Rhei, half late summer practiced honey for water-honeyed pill, be finished product after packaging.
Condensed cream also can be dried into powder and Radix Et Rhizoma Rhei half and mix late summer evenly and incapsulate by the present invention, is finished product after packaging.
In prescription of the present invention, Fructus Gleditsia, the Rhizoma Pinelliae, Pericarpium Trichosanthis, Bulbus Allii Macrostemonis, Semen Armeniacae Amarum, Semen Sinapis Albae acrid in the mouth are slided, fluent mechanism of qi, the logical intestinal knot of temperature; Cortex Magnoliae Officinalis, Fructus Aurantii, DABAIPIAN, the scale removal of bowel relieving promoting the circulation of QI, because of lung being connected with large intestine, add Radix Platycodonis, Fructus Arctii, the pungent profit hardship of Semen Armeniacae Amarum fall, opening lung-energy helps and falls; With Concha Ostreae, the kidney invigorating of softening the hard mass eliminate indigestion easing the affected liver arresting seminal emission; Increase liquid nourishing the liver with Radix Angelicae Sinensis benefiting vital QI and blood to moisturize, the catharsis of liver department.The medicine of of the present invention group, coordinate to share its duty of each department, become to mend intensive culture liquid, softening the hard mass eliminate indigestion, circulation of qi promoting scale removal loosening bowel to relieve constipation, constipation is cured.This medicine can treat various constipation.
Advantage of the present invention is: the present invention is clinical experiences decades, progressively improves through repeatedly studying, the medicine of last successful a kind of good treatment habitual constipation.Therapeutic effect is good, and short treating period has no side effect, and treatment cost is low, has no side effect, treatment habitual constipation Be very effective.
For investigating clinical efficacy and the safety of medicine of the present invention further, selection treatment group, each 120 examples of matched group carry out clinical observation to the curative effect of medicine of the present invention.It is oral at twice that treatment group every patient every day takes medicine of the present invention 4, and the morning, once afternoon once.Matched group routine administration.
Therapeutic effect standard of the present invention:
Cure: constipation disease disappears, and does not recur.
Take a turn for the better: constipation disease alleviates.
Do not heal: symptom is without improvement.
Cure Take a turn for the better Cure rate Effective percentage
Treatment group 100 119 83.3% 99.1%
Matched group 20 118 16.6% 98.3%
Treatment group is compared matched group and is had higher cure rate and effective percentage.Think that the present invention will have better effects to treatment constipation thus.By observing for many years, and bimestrial comparison is observed, and takes medicine of the present invention and does not occur any toxic and side effects.
Through treating 120 examples, clinical cure 100 example, take a turn for the better 19 examples, and do not heal 1 example, total effective rate 99.1%.Without any side effect and untoward reaction.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but do not form any limitation of the invention.
Embodiment one:
Raw material is prepared: Pericarpium Trichosanthis 600kg, Bulbus Allii Macrostemonis 900kg, Cortex Magnoliae Officinalis 150kg by following weight, DABAIPIAN 150kg, Fructus Aurantii 150kg, Radix Platycodonis 150kg, Fructus Arctii 150kg, Semen Armeniacae Amarum 150kg, Semen Sinapis Albae 150kg, Radix Angelicae Sinensis 150kg, Concha Ostreae 300kg, Radix Scutellariae 150kg, nine Radix et Rhizoma Rhei (processed) 150kg, Fructus Gleditsia 40kg, Rhizoma Pinelliae Preparata 200kg, Radix Et Rhizoma Rhei 150kg.
Nine Radix et Rhizoma Rhei (processed), Radix Et Rhizoma Rhei, the Rhizoma Pinelliae are ground as smalls is for subsequent use, by said medicine except Radix Et Rhizoma Rhei, the Rhizoma Pinelliae, after soaking 2 days, put into boiling machine, water crosses powder, and slow fire boiling was condensed into cream after 2 hours, adding Radix Et Rhizoma Rhei Pinellia Tuber white silk honey is water-honeyed pill, makes finished product after packaging.
Embodiment two:
Raw material is prepared: Pericarpium Trichosanthis 600kg, Bulbus Allii Macrostemonis 900kg, Cortex Magnoliae Officinalis 150kg by following weight, DABAIPIAN 150kg, Fructus Aurantii 150kg, Radix Platycodonis 150kg, Fructus Arctii 150kg, Semen Armeniacae Amarum 150kg, Semen Sinapis Albae 150kg, Radix Angelicae Sinensis 150kg, Concha Ostreae 300kg, Radix Scutellariae 150kg, nine Radix et Rhizoma Rhei (processed) 150kg, Fructus Gleditsia 40kg, Rhizoma Pinelliae Preparata 200kg, Radix Et Rhizoma Rhei 150kg.
Nine Radix et Rhizoma Rhei (processed), Radix Et Rhizoma Rhei, the Rhizoma Pinelliae are ground as smalls is for subsequent use, by said medicine except Radix Et Rhizoma Rhei, the Rhizoma Pinelliae, after soaking 2 days, put into boiling machine, water crosses powder, and slow fire boiling was condensed into cream after 2 hours, adding Radix Et Rhizoma Rhei Pinellia Tuber white silk honey is water-honeyed pill, makes finished product after packaging.
Embodiment three:
Raw material is prepared: Pericarpium Trichosanthis 600kg, Bulbus Allii Macrostemonis 900kg, Cortex Magnoliae Officinalis 150kg by following weight, DABAIPIAN 150kg, Fructus Aurantii 150kg, Radix Platycodonis 150kg, Fructus Arctii 150kg, Semen Armeniacae Amarum 150kg, Semen Sinapis Albae 150kg, Radix Angelicae Sinensis 150kg, Concha Ostreae 300kg, Radix Scutellariae 150kg, nine Radix et Rhizoma Rhei (processed) 150kg, Fructus Gleditsia 40kg, Rhizoma Pinelliae Preparata 200kg, Radix Et Rhizoma Rhei 150kg;
Grind as smalls is for subsequent use by nine Radix et Rhizoma Rhei (processed), Radix Et Rhizoma Rhei, the Rhizoma Pinelliae, by said medicine except Radix Et Rhizoma Rhei, the Rhizoma Pinelliae, after soaking 2 days, put into boiling machine, water crosses powder, and slow fire boiling was condensed into cream after 2 hours;
Medicine-feeding is condensed into cream be dried into powder and mix Radix Et Rhizoma Rhei, half late summer evenly incapsulate in make capsule, packaging after be finished product.

Claims (3)

1. medicine for the treatment of habitual constipation and preparation method thereof, is characterized in that:
The medicine for the treatment of habitual constipation of the present invention is that raw material prepares by the Chinese medicine of following parts by weight:
Pericarpium Trichosanthis 30-60 Bulbus Allii Macrostemonis 60-90 Cortex Magnoliae Officinalis 10-15
DABAIPIAN 10-15 Fructus Aurantii 10-15 Radix Scutellariae 10-30
Concha Ostreae 20-30 Radix Platycodonis 10-15 Fructus Arctii 10-15
Semen Armeniacae Amarum 10-15 Radix Angelicae Sinensis 20-30 Rhizoma Pinelliae Preparata 10-20
Semen Sinapis Albae 15-20 Fructus Gleditsia 15-20 nine Radix et Rhizoma Rhei (processed) 10-15
Radix Et Rhizoma Rhei 15-20.
2. the medicine and preparation method thereof for the treatment of habitual constipation according to claim 1, is characterized in that described medicine to make water-honeyed pill.
3. the preparation method for the treatment of habitual constipation according to claim 1, it is characterized in that: first nine Radix et Rhizoma Rhei (processed), Radix Et Rhizoma Rhei, Rhizoma Pinelliae Preparata are ground as smalls mixing for standby use, again by Pericarpium Trichosanthis, Bulbus Allii Macrostemonis, Cortex Magnoliae Officinalis, DABAIPIAN, Fructus Aurantii, Concha Ostreae, Radix Platycodonis, Fructus Arctii, Semen Armeniacae Amarum, Radix Angelicae Sinensis, Radix Scutellariae, Fructus Gleditsia, Semen Sinapis Albae, soak, water crosses powder, boiling machine is put into after 48 hours, slow fire boiling 2 hours, take out filtrate, decocting and concentrating becomes cream again, add Radix Et Rhizoma Rhei, half late summer practiced honey for water-honeyed pill, after packaging, be finished product.
CN201410628618.2A 2014-11-11 2014-11-11 Medicine for treating habitual constipation and preparation method thereof Pending CN104435597A (en)

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Publication number Priority date Publication date Assignee Title
CN104958746A (en) * 2015-08-01 2015-10-07 朱克兰 Foot bath composition for treating constipation and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104958746A (en) * 2015-08-01 2015-10-07 朱克兰 Foot bath composition for treating constipation and preparation method thereof

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Application publication date: 20150325