CN101623474B - Preparation method of Shengui antler oral solid preparation - Google Patents
Preparation method of Shengui antler oral solid preparation Download PDFInfo
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- CN101623474B CN101623474B CN2009100060798A CN200910006079A CN101623474B CN 101623474 B CN101623474 B CN 101623474B CN 2009100060798 A CN2009100060798 A CN 2009100060798A CN 200910006079 A CN200910006079 A CN 200910006079A CN 101623474 B CN101623474 B CN 101623474B
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Abstract
The invention relates to a preparation method of an oral solid traditional Chinese medicine preparation, in particular to a preparation method of a Shengui antler oral solid preparation. In the preparation method, medicinal materials are subjected to superfine grinding and are extracted, thus retaining the active ingredients in the medicinal materials, being beneficial for the patients to absorb the active ingredients, improving the resource utilization ratio of the medicinal materials and achieving the purpose of reducing the daily dosage of the patients by reducing the dose of the crude medicine powder.
Description
Technical field
The present invention relates to a kind of preparation method of extract oral solid preparation, particularly relate to the Shengui antler oral solid formulation preparation method.
Background technology
The Shengui antler preparation prescription is from the 3rd of Chinese medicine ministry standard, and this prescription has the effect of QI invigorating kidney tonifying, spermatogenesis benefit marrow, nourishing blood for regulating menstruation, is used for Qi and blood deficiency, and what deficiency of the liver and kindey caused has a delicate constitution, soreness of the waist and knees, dizziness and tinnitus, spontaneous sweating, insomnia and dreamful sleep, cold womb leukorrhagia, menoxenia etc.
Modern medicine is all thought material base that Chinese medicine prevents and cures diseases from biological activity position or active chemical components, and therefore, general traditional medicine scholar's attention mainly concentrates on to seek to be had on the various bioactive chemical compounds.But through the modern science personnel traditional Chinese medical science, Chinese medicine further investigation are shown: living organism is an extremely complex physical chemical process to absorption, metabolism and the drainage of medicine, the pharmacodynamics effect that Chinese medicine produces can not give the credit to this medicine special chemical component uniquely, and is also closely related with the physical state of medicine etc.Therefore, changing the physical state of medicine, is the raising drug effect, also is a kind of method that is worth trying to explore of development newtype drug.
From having had many scientific and technical personnel some Chinese crude drug to be changed the test of drug unit size (volume) the disclosed documents and materials at present, result of the test shows, change crude drug with distinct methods, make it to make the granularity difference, the biological activity of its medicine and availability all can be largely increased.Its reason is: the dissolution rate of medicine is directly proportional with the specific grain surface of medicine is long-pending, and this surface area and particle diameter are inversely proportional to.Therefore, the particle diameter of medicine is thin more, and its surface area is big more, helps the stripping of effective ingredient more.
Micron Chinese medicine that present stage uses and nanometer Chinese medicine are meant that adopting the modern high technology nanotechnology to combine with the tradition process of preparing Chinese medicine and preparation technique develops; can effectively keep herbal medicine efficacy material base, particle diameter to be respectively 0.1-10 μ m micron particles or particle diameter new medicine less than 0.1 μ m nano-scale particle.
Shengui antler preparation dosage form at present on sale is mainly based on small honey pill, water-honeyed pill and big honeyed pills, any dosage form no matter, and all more than 8 grams, from the angle of consumer, consumption is too big, takes inconvenience, is not more and more accepted by consumer for the dose of single.Contain the multi-flavor valuable medicinal in this prescription in addition, and most of raw medicinal material all is the more expensive tonification medical material of price.Along with raw medicinal material in recent years generally goes up, price of medicinal materials such as Stigma Croci, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae connect in a short time and turn over several times, price of medicinal material amounts of increase such as Radix Ginseng, Cornu Cervi Pantotrichum, Fructus Corni, Semen Ziziphi Spinosae, Lignum Aquilariae Resinatum are also more than 30%, and it directly has influence on the manufacturing cost of Shengui antler ball.In addition, all full powder of multi-flavor medical material is used as medicine, and can not reach the effect of drug absorption effectively.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and a kind of preparation method of Shengui antler oral solid preparation is provided.
The prescription of Shengui antler oral solid preparation adopts the Shengui antler ball prescription that the 3rd of Chinese medicine ministry standard recorded, promptly following weight portion: 120 parts of Radix Ginsengs among the present invention, 240 parts in Cornu Cervi Pantotrichum (unhairing), 120 parts of Fructus Corni (wine is processed), 240 parts of Radix Rehmanniae, 240 parts of Radix Rehmanniae Preparata, 240 parts of the Radix Paeoniae Albas, 120 parts of Carapax Et Plastrum Testudiniss (the husky quench in vinegar that scalds), 120 parts of Carapax Trionycis (the husky quench in vinegar that scalds), 360 parts in Colla Corii Asini, 120 parts of the Cortexs Eucommiae (parch to black), 120 parts of Radix Dipsacis, 162 parts of Radix Asparagis, 240 parts in Poria, 120 parts of Semen Ziziphi Spinosaes (stir-fry), 60 parts of succinums, 120 parts of Folium Artemisiae Argyis (parch to black), 480 parts of Pericarpium Citri Reticulataes, 120 parts of Rhizoma Alismatis, 120 parts of Myrrhas (processed with vinegar), 90 parts of Olibanums (processed with vinegar), 90 parts of Rhizoma Corydalis (processed with vinegar), 90 parts on Flos Carthami, 60 parts of Stigma Crocis, 138 parts of Radix Achyranthis Bidentataes (decaptitating), 120 parts of Radix Cyathulaes (decaptitating), 1 80 parts of Flos Celosiae Cristataes, 90 parts of Halloysitum Rubrums (forging), 360 parts of Rhizoma Cyperis (processed with vinegar), 60 parts in Radix Glycyrrhizae, 120 parts of Radix Gentianae Macrophyllae, 150 parts of Radix Scutellariaes, 180 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 30 parts of the Radix Aucklandiae, 120 parts of Fructus Amomis, 30 parts of Lignum Aquilariae Resinatum, 240 parts of Radix Angelicae Sinensis, 180 parts of Rhizoma Chuanxiongs, 120 parts of Cortex Cinnamomis.
Technical problem to be solved by this invention is achieved through the following technical solutions, and it may further comprise the steps:
(1) gets at least a in Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and the Cortex Cinnamomi 19 flavor medical materials, drying is ground into fine powder material;
(2) Fructus Corni, Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Dipsaci, Radix Asparagi, Poria, Semen Ziziphi Spinosae, Folium Artemisiae Argyi, Rhizoma Alismatis, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Radix Cyathulae, Flos Celosiae Cristatae, Halloysitum Rubrum, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Radix Scutellariae 19 flavor medical materials remaining medical material in step (1) are decocted with water, get medicinal liquid;
(3) the described medicinal liquid of step (2) is concentrated concentrated solution;
(4) add step (1) comminuting matter in the concentrated solution, make principal agent;
(5) principal agent interpolation pharmacy acceptable auxiliary is made the Shengui antler oral solid preparation.
The particle diameter of at least a mixed powder that is ground in the Radix Ginseng in the described step (1), Cornu Cervi Pantotrichum etc. the 19 flavor medical materials is for being main fine powder less than 150 μ m, preferred 10-150 μ m, and preferred 0.1-10 μ m is more preferably less than the fine powder of 0.1 μ m.The relative density of the concentrated solution of described step (3) gained is 1.05-1.38, preferred 1.15-1.28.
A kind of Shengui antler oral solid preparation according to above technical scheme proposition, compare with the water-honeyed pill preparation with the large and small honeyed pill of this kind, it has following feature: the first is ground into fine powder with valuable medicinals such as Radix Ginseng, Cornu Cervi Pantotrichum, Stigma Croci, Lignum Aquilariae Resinatum, Carapax Et Plastrum Testudiniss and is used as medicine, so both helped its effective ingredient stripping, also help the patient and absorb, improve the herb resource utilization rate; It two is the part medical material to be boiled carry, and discards the dross and selects the essential, and is condensed into thick paste and is used as medicine, and goes into dose and then reaches the purpose that reduces patient's day dose by reducing the crude drug powder.
Obviously, according to foregoing of the present invention, those skilled in the art can also make other forms of modification, replacement or change not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples, and Dan Buying is interpreted as that with this scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The invention provides a kind of preparation method of Shengui antler oral solid preparation, form by the following examples is further described foregoing of the present invention.
Embodiment one
(1) gets Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and Cortex Cinnamomi 19 flavor medical materials, dry, be ground into the micropowder of 0.1-10 μ m particle diameter, standby;
(2) all the other 19 flavor medical materials are added 4 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.05-1.12 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make tablet.
Embodiment two
(1) gets Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and Cortex Cinnamomi 19 flavor medical materials, dry, be ground into the fine powder of 10-150 μ m particle diameter, standby;
(2) all the other 19 flavor medical materials are added 6 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.30-1.38 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make concentrated pill.
Embodiment three
(1) gets Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and Cortex Cinnamomi 19 flavor medical materials, dry, be ground into nano powder less than 0.1 μ m particle diameter, standby;
(2) all the other 19 flavor medical materials are added 8 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.22-1.28 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make granule.
Embodiment four
(1) gets Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and Cortex Cinnamomi 19 flavor medical materials, dry, be ground into nano powder less than 0.1 μ m particle diameter, standby;
(2) all the other 19 flavor medical materials are added 10 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.05-1.10 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make capsule.
Embodiment five
(1) gets Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and Cortex Cinnamomi 19 flavor medical materials, dry, be ground into fine powder less than 150 μ m particle diameters, standby;
(2) all the other 19 flavor medical materials are added 12 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.30-1.38 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make drop pill.
Embodiment six
(1) get Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis and Cortex Cinnamomi ten medical material simply, drying is ground into the fine powder of 10-150 μ m particle diameter, and is standby;
(2) all the other 20 seven flavor medicine materials are added 4 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.05-1.18 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make concentrated pill.
Embodiment seven
(1) get Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis, Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae and Pericarpium Citri Reticulatae ten four Chinese medicine materials, drying is ground into the nano powder less than 0.1 μ m particle diameter, and is standby;
(2) all the other 20 four Chinese medicine materials are added 12 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.20-1.30 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make capsule.
Embodiment eight
(1) get Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami and Cortex Cinnamomi four Chinese medicine material, drying is ground into the fine powder less than 150 μ m particle diameters, and is standby;
(2) its excess-three ten four Chinese medicine materials are added 8 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.30-1.38 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make drop pill.
Embodiment nine
(1) get the fine powder that the Radix Ginseng powder is broken into 10-150 μ m particle diameter, standby;
(2) its excess-three ten seven flavor medicine materials are added 6 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.30-1.38 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make concentrated pill.
Embodiment ten
(1) get Radix Ginseng, Cornu Cervi Pantotrichum two flavor medical materials, drying is ground into the fine powder less than 150 μ m particle diameters, and is standby;
(2) all the other 36-flavor Glutinous medical materials are added 12 times of water gagings and decoct 2 times, each 2 hours, medicinal liquid filtered, and being condensed into relative density is the concentrated solution of 1.30-1.38 (55-60 ℃);
(3) add above-mentioned comminuting matter and appropriate amount of auxiliary materials in the concentrated solution, make drop pill.
Claims (3)
1. the preparation method of a Shengui antler oral solid preparation is characterized in that may further comprise the steps:
1) gets at least a in Radix Ginseng, Cornu Cervi Pantotrichum, Flos Carthami, Stigma Croci, Colla Corii Asini, Olibanum, Myrrha, succinum, Carapax Et Plastrum Testudinis Carapax Trionycis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Fructus Amomi, Lignum Aquilariae Resinatum, Rhizoma Cyperi and the Cortex Cinnamomi 19 flavor medical materials, dry, be ground into fine powder material, the particle diameter of the fine powder material after the pulverizing is less than 0.1 μ m, and is standby;
2) Fructus Corni, Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Dipsaci, Radix Asparagi, Poria, Semen Ziziphi Spinosae, Folium Artemisiae Argyi, Rhizoma Alismatis, Rhizoma Corydalis, Radix Achyranthis Bidentatae, Radix Cyathulae, Flos Celosiae Cristatae, Halloysitum Rubrum, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Radix Scutellariae 19 flavor medical materials remaining medical material in step 1) are decocted with water, get medicinal liquid;
3) with step 2) described medicinal liquid concentrate concentrated solution, its relative density is 1.05-1.38;
4) add the step 1) comminuting matter in the concentrated solution, make principal agent;
5) principal agent interpolation pharmacy acceptable auxiliary is made the Shengui antler oral solid preparation;
Wherein, described Cornu Cervi Pantotrichum is the unhairing Cornu Cervi Pantotrichum; Olibanum is the processed with vinegar Olibanum; Myrrha is the processed with vinegar Myrrha; Carapax Et Plastrum Testudinis is the husky quench in vinegar Carapax Et Plastrum Testudinis that scalds; Carapax Trionycis is the husky quench in vinegar Carapax Trionycis that scalds; The Rhizoma Atractylodis Macrocephalae is a Rhizoma Atractylodis Macrocephalae (parched with bran); Rhizoma Cyperi is a Rhizoma Cyperi (processed with vinegar); Fructus Corni is the wine Fructus Corni Preparata; The Cortex Eucommiae is the parch to black Cortex Eucommiae; Semen Ziziphi Spinosae is a Semen Ziziphi Spinosae (parched); Folium Artemisiae Argyi is the parch to black Folium Artemisiae Argyi; Rhizoma Corydalis is a Rhizoma Corydalis (processed with vinegar); Radix Achyranthis Bidentatae is the Radix Achyranthis Bidentatae of decaptitating; Radix Cyathulae is the Radix Cyathulae that decaptitates; Halloysitum Rubrum is a Halloysitum Rubrum(calcined).
2. preparation method according to claim 1, the relative density that it is characterized in that the concentrated solution of step 3) gained is 1.15-1.28.
3. method according to claim 1 is characterized in that described oral solid formulation is granule, tablet, capsule, concentrated pill or drop pill.
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| CN106509553A (en) * | 2016-09-30 | 2017-03-22 | 深圳市贝沃德克生物技术研究院有限公司 | Health promotion based drink suitable for insomnia groups to drink and preparation method thereof |
| CN112353916A (en) * | 2020-09-25 | 2021-02-12 | 健民药业集团股份有限公司 | Ginseng-cassia antler granules and preparation method thereof |
| CN116688080A (en) * | 2023-07-01 | 2023-09-05 | 河南润弘本草制药有限公司 | Ginseng, cassia bark and pilose antler pill and preparation method thereof |
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2009
- 2009-01-22 CN CN2009100060798A patent/CN101623474B/en active Active
Non-Patent Citations (6)
| Title |
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| 中华人民共和国卫生部药典委员会.《参桂鹿茸丸》.《药品标准 中药成方制剂 第三册》.1991,111. * |
| 杨晓波.《纳米技术在中药制剂中的应用》.《药学实践杂志》.2007,第25卷(第2期),65-67. |
| 石焱 |
| 石焱;罗佳波;袭荣刚;杨晓波.《纳米技术在中药制剂中的应用》.《药学实践杂志》.2007,第25卷(第2期),65-67. * |
| 罗佳波 |
| 袭荣刚 |
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