CN100415214C - Preparing method gynaecologic capsule for regulating menstruation - Google Patents
Preparing method gynaecologic capsule for regulating menstruation Download PDFInfo
- Publication number
- CN100415214C CN100415214C CNB031189245A CN03118924A CN100415214C CN 100415214 C CN100415214 C CN 100415214C CN B031189245 A CNB031189245 A CN B031189245A CN 03118924 A CN03118924 A CN 03118924A CN 100415214 C CN100415214 C CN 100415214C
- Authority
- CN
- China
- Prior art keywords
- rhizoma
- radix
- medicine
- time
- angelicae sinensis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000002775 capsule Substances 0.000 title claims abstract description 6
- 230000005906 menstruation Effects 0.000 title abstract description 4
- 230000001105 regulatory effect Effects 0.000 title abstract description 4
- 238000000034 method Methods 0.000 title description 2
- 239000000843 powder Substances 0.000 claims abstract description 25
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 241000218176 Corydalis Species 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 9
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 7
- 238000007689 inspection Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 235000021419 vinegar Nutrition 0.000 claims description 6
- 239000000052 vinegar Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims description 3
- 229910001385 heavy metal Inorganic materials 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 claims 1
- 230000006837 decompression Effects 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 9
- 239000000463 material Substances 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 3
- 238000003908 quality control method Methods 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 208000004998 Abdominal Pain Diseases 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000234653 Cyperus Species 0.000 abstract 1
- 208000019255 Menstrual disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003821 menstrual periods Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000003390 Chinese drug Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a preparation method of a gynaecologic capsule for regulating menstruation. The present invention is characterized in that four kinds of traditional Chinese medicines, such as white atractylodes rhizome, etc. are pulverized; six kinds of traditional Chinese medicines, such as cyperus tuber, etc. are added with water to be decocted; the decocted liquid is concentrated into thick paste; the fine powder and auxiliary materials are added to be granulated, dried and encapsulated, or the decocted liquid is concentrated and dried to be prepared into dry paste powder which is encapsulated after being uniformly mixed with the fine powder and the auxiliary materials, and the whole preparation process is finished. Compared with the original preparation type, the medicine has the advantages of reasonable technology, and simple and convenient production; the affective ingredients of the medicine can be better reserved; the therapeutic effect is enhanced; quality control standards are roundly enhanced. The present invention has important significance for enhancing product quality, and is capable of better satisfying and ensuring people's medication requirements. The medicine has the functions of nourishing blood, regulating menstruation and alleviating pain, and is used for treating symptoms of menoxenia, bellyache in menstrual periods, etc. The medicine is convenient to carry and use, is a safe, stable and effective medicine and is an ideal product of modern pharmaceutical enterprises.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine capsule, relates in particular to FUKE TIAOJING JIAONANG and preparation method.
Background technology
Capsule is a kind of form of Chinese drug, according to the relevant drug act of China, changes dosage form as a kind of new drug research, former dosage form has gynecological's regulating menstruation sheet, listed in the 5th of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ", the technology of former dosage form is: four flavors such as Radix Angelicae Sinensis are ground into fine powder in the prescription, and Six-elements such as all the other Rhizoma Cyperis decoct with water, decocting liquid filters and is condensed into thick paste, add above-mentioned fine powder and auxiliary materials and mixing, granulate drying, tabletting, sugar coating forms.This tablet fine powder such as Radix Angelicae Sinensis aborning will be through granulating, dry this step, and volatile ingredient easily loses, and affect the treatment, and the coated tablet coating is loaded down with trivial details, and disintegrate is slow, and this target level of product quality is low simultaneously, no quantitative target.Based on the shortcoming that former tablet exists, we use the modern pharmaceutical technology this product technology are done necessary the improvement, form new preparation, guarantee the quality monitoring of product, improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of FUKE TIAOJING JIAONANG and preparation method, improve the quality of products and curative effect, increase the stability of product, satisfy needs of medical treatment better.
The objective of the invention is such realization:
FUKE TIAOJING JIAONANG and preparation method comprise the steps:
One, the prescription of FUKE TIAOJING JIAONANG is formed
Radix Angelicae Sinensis 70～220g Rhizoma Chuanxiong 8～24g Rhizoma Cyperi (processed with vinegar) 200-600g Rhizoma Atractylodis Macrocephalae (Bran stir-fry) 10～35g
The Radix Paeoniae Alba 6～18g Radix Paeoniae Rubra 6～18g Rhizoma Corydalis (processed with vinegar) 16～48g Radix Rehmanniae Preparata 24～72g
Fructus Jujubae 40～120g Radix Glycyrrhizae 5～17g
Right amount of auxiliary materials is made 1000 altogether.
Optimum formula is:
Radix Angelicae Sinensis 144g Rhizoma Chuanxiong 16g Rhizoma Cyperi (processed with vinegar) the 400g Rhizoma Atractylodis Macrocephalae (Bran stir-fry) 23g Radix Paeoniae Alba 12g
Radix Paeoniae Rubra 12g Rhizoma Corydalis (processed with vinegar) 32g Radix Rehmanniae Preparata 48g Fructus Jujubae 80g Radix Glycyrrhizae 11g
Right amount of auxiliary materials is made 1000 altogether.
Two, FUKE TIAOJING JIAONANG preparation technology
Technology one cleans ten flavor medical materials respectively, removes impurity, and it is standby to be up to the standards; The Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Radix Angelicae Sinensis, Rhizoma Chuanxiong power are broken into fine powder, and Six-elements such as all the other Rhizoma Cyperis decoct with water 2-3 time, filter, and filtrate merges, and is condensed into thick paste, adds above-mentioned fine powder and right amount of auxiliary materials, and mixing is granulated, dry, encapsulated below 60 ℃, and quality inspection, packing, promptly.
Technology two cleans ten flavor medical materials respectively, removes impurity, and it is standby to be up to the standards; The Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Radix Angelicae Sinensis, Rhizoma Chuanxiong power are broken into fine powder, and Six-elements such as all the other Rhizoma Cyperis decoct with water 2-3 time, filter, and filtrate merges, and concentrate drying is made dried cream powder, and is encapsulated with above-mentioned fine powder and right amount of auxiliary materials mixing, quality inspection, and packing, promptly.
Three, prepared by technology one, two is capsule.
Four flavors such as the Rhizoma Atractylodis Macrocephalae are ground into fine powder in the technology, are generally 80-160 order fine powder, and best to be broken into 200-300 order fine powder standby for superfine powder.
Six-element pulverizing medicinal materials such as Rhizoma Cyperi became 5-30 purpose coarse powder or cut decoction pieces in the technology, was preferably 10 order coarse powder.
The condition that decocting boils in the technology is: decoct 2-3 time, amount of water is doubly measured for the 6-15 of dose for the first time, and second and third time doubly measured for the 4-10 of dose, and decocting time is 1-4 hour for the first time, and second and third time is 0.5-3 hour.The best is: decoct 2 times, amount of water is 10 times of amounts of dose for the first time, is 8 times of amounts of dose for the second time, and the time is 2 hours for being 3 hours for the first time for the second time.
Drying can adopt drying under reduced pressure or spray drying in the technology.The drying under reduced pressure temperature is controlled at 40-80 ℃, and the best is 50 ℃.Spray drying is for to be condensed into the thick paste that relative density is 1.05-1.15 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100-200 ℃, and leaving air temp is 50-150 ℃.Best relative density is 1.08 (60 ℃), and inlet temperature is 160 ℃, and leaving air temp is 100 ℃.
Concentrate in the technology and can adopt concentrating under reduced pressure or thin film concentration.
Added adjuvant can be in the technology: any or multiple mixing in micropowder silica gel, starch, dextrin, the magnesium stearate etc. is used.
Extracting solution filters and also can adopt centrifugation method in the technology.
This product quality control mainly is discriminating, inspection, three aspects of assay, former dosage form has been carried out the thin layer discriminating to Rhizoma Corydalis on differentiating, now given reservation, and increased the thin layer of Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae has been differentiated, on checking, increased the limit examine of heavy metal, arsenic salt, the regulation heavy metal limit must not cross 10/1000000ths, and arsenic salt must not limit the quantity of 2/1000000ths; On assay, the Radix Paeoniae Alba has been carried out quantitatively.
This invention its superiority compared with the prior art is: technology is more reasonable, produces easylier, can better keep effective ingredient, and quality standard has new raising again, makes product that the qualitative, quantitative control method of science be arranged, and makes the quality of product that guarantee arranged.
The specific embodiment
The optimum implementation of this invention is that ten flavor medical materials are cleaned respectively, removes impurity, and it is standby to be up to the standards; The Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Radix Angelicae Sinensis, Rhizoma Chuanxiong power are broken into fine powder, and Six-elements such as all the other Rhizoma Cyperis decoct with water 2-3 time, filter, and filtrate merges, and concentrate drying is made dried cream powder, and is encapsulated with above-mentioned fine powder and right amount of auxiliary materials mixing, quality inspection, and packing, promptly.
Claims (2)
1. the preparation method of a FUKE TIAOJING JIAONANG, it is characterized in that, it is to be raw material with Radix Angelicae Sinensis 144g, Rhizoma Chuanxiong 16g, Rhizoma Cyperi (processed with vinegar) 400g, Rhizoma Atractylodis Macrocephalae (parched with bran) 23g, Radix Paeoniae Alba 12g, Radix Paeoniae Rubra 12g, Rhizoma Corydalis (processed with vinegar) 32g, Radix Rehmanniae Preparata 48g, Fructus Jujubae 80g, Radix Glycyrrhizae 11g, prepares 1000 of capsules according to the following steps:
(1) Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis superfine powder are broken into 200～300 purpose fine powders, standby;
(2) Rhizoma Cyperi, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Fructus Jujubae, Radix Glycyrrhizae powder are broken into 10 purpose coarse powder, decoct with water 2 times, amount of water is 10 times of amounts of dose for the first time, and decocting time is 3 hours; Amount of water is 8 times of amounts of dose for the second time, and decocting time is 2 hours; The employing centrifugation method filters, and merges filtrate twice; Filtrate decompression is condensed into to survey relative density 60 ℃ the time be 1.08 thick paste; The thick paste spray drying is that micropowder is preserved; Spray-dired inlet temperature is 160 ℃, and leaving air temp is 100 ℃;
(3) with the fine powder of thick paste and the above-mentioned Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, and any or multiple mixture mixing in the adjuvant micropowder silica gel, starch, dextrin, magnesium stearate, granulate, encapsulated, quality inspection gets product.
2. the preparation method of FUKE TIAOJING JIAONANG according to claim 1, it is characterized in that: described quality inspection comprises to be differentiated the thin layer of Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, to heavy metal limit must not cross 1,000,000/, arsenic salt must not limit the quantity of 2/1000000ths limit detection, and to the detection by quantitative of peoniflorin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031189245A CN100415214C (en) | 2003-04-10 | 2003-04-10 | Preparing method gynaecologic capsule for regulating menstruation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031189245A CN100415214C (en) | 2003-04-10 | 2003-04-10 | Preparing method gynaecologic capsule for regulating menstruation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1456289A CN1456289A (en) | 2003-11-19 |
| CN100415214C true CN100415214C (en) | 2008-09-03 |
Family
ID=29411424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031189245A Expired - Lifetime CN100415214C (en) | 2003-04-10 | 2003-04-10 | Preparing method gynaecologic capsule for regulating menstruation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100415214C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323709C (en) * | 2004-12-09 | 2007-07-04 | 朱本海 | Traditional Chinese medicine decoction for treating gynecological diseases |
| CN100415253C (en) * | 2005-03-01 | 2008-09-03 | 重庆大易科技投资有限公司 | Medicinal composition for treating dysmenorrhea and preparation method thereof |
| CN102805796B (en) * | 2012-08-29 | 2014-03-26 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating abnormal menstruation and preparation method thereof |
| CN103251769B (en) * | 2013-05-03 | 2015-03-11 | 吉林万通药业集团梅河药业股份有限公司 | Gynecological menstruation-regulating tablet and preparation method thereof |
| CN113101330B (en) * | 2021-04-09 | 2022-06-17 | 一力制药(南宁)有限公司 | Menstruation regulating composition and application thereof |
-
2003
- 2003-04-10 CN CNB031189245A patent/CN100415214C/en not_active Expired - Lifetime
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂第五册. 中华人民共和国卫生部药典委员会，70. 1992 |
| 中华人民共和国卫生部药品标准中药成方制剂第五册. 中华人民共和国卫生部药典委员会，70. 1992 * |
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| Publication number | Publication date |
|---|---|
| CN1456289A (en) | 2003-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20060127 Address after: No. 45 Hawthorn Road, Yunyan District, Guizhou, Guiyang Applicant after: Du Zhongxing Address before: Jiangxi Province, Nanchang City Lake Magi residential area 34 building 3 unit 301 room Applicant before: Mao Youchang |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: GUIZHOU WEIKANG MEDICINE CO., LTD. Free format text: FORMER OWNER: DU ZHONGXING Effective date: 20090703 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20090703 Address after: Guizhou city in Guiyang province of China Road No. 45 Building 9 floor E block Huakun development Patentee after: Guizhou Weikang Pharmaceutical Co.,Ltd. Address before: No. 45 Hawthorn Road, Yunyan District, Guizhou, Guiyang Patentee before: Du Zhongxing |
|
| DD01 | Delivery of document by public notice |
Addressee: Guizhou Weikang Pharmaceutical Co.,Ltd. Document name: Notification to Pay the Fees |
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| DD01 | Delivery of document by public notice |
Addressee: Guizhou Weikang Pharmaceutical Co.,Ltd. Document name: Notification of Termination of Patent Right |
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| DD01 | Delivery of document by public notice |
Addressee: Guizhou Weikang Pharmaceutical Co.,Ltd. Document name: Notification of Decision on Request for Restoration of Right |
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| DD01 | Delivery of document by public notice | ||
| CP03 | Change of name, title or address |
Address after: 6, 9 floor, 42 international office building, No. 550002 South Road, Nanming District, Guiyang, Guizhou, China Patentee after: GUIZHOU WEIKANG ZIFAN PHARMACEUTICAL CO.,LTD. Address before: 550002 Guizhou city of Guiyang province of China Road No. 45 Building 9 floor E block Huakun development Patentee before: Guizhou Weikang Pharmaceutical Co.,Ltd. |
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| CP03 | Change of name, title or address | ||
| CX01 | Expiry of patent term |
Granted publication date: 20080903 |
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