CN1456294A

CN1456294A - Qingzhuoqudu tablets for removing toxicity and preparation thereof

Info

Publication number: CN1456294A
Application number: CN 03118931
Authority: CN
Inventors: 毛友昌; 毛晓敏
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-04-10
Filing date: 2003-04-10
Publication date: 2003-11-19

Abstract

A process for preparing Chinese medicine "Qingzuo-Qudu particles" for treating frequent urination, micturition, urgency and urodynia includes such steps as pulverizing 7 Chinese-medicinal materials including tree peony bark, decocting another 5, concentrating, drying, adding additive, mixing all together, granulating and drying. Its advantage is high curative effect and safety.

Description

Pure and impure malicious granule and the preparation method of dispelling

Technical field

This invention relates to the processing technology technical field of Chinese patent medical granule, relates in particular to pure and impure malicious granule and the preparation method of dispelling.

Background technology

Granule is a kind of form of Chinese drug, according to the relevant drug act of China, change dosage form as a kind of new drug research, former dosage form has the pure and impure poison pill of dispelling, and listed in National Drug Administration's country's standard for traditional Chinese medicines compilation-Chinese patent medicine provincial standard rising national standard part " surgery fascicle ", form by 12 flavor Chinese medicines.The technology of former dosage form is: seven flavor medicine materials such as Cortex Moutan are ground into fine powder, and the five tastes such as all the other Herba lygodii are made decocting in water cream, are mixed and made into water pill then and form.But this pill dose is big, and ampoule is 8g, 60 balls, Ms difficulty swallows, and control product quality quality standard still can further improve, with further control product quality.Have the shortcoming that influences quality based on pill, we use the modern pharmaceutical technology this product technology are done necessary the improvement, form new preparation, guarantee the quality monitoring of product, improve drug effect, benefit the common people.

Summary of the invention

The purpose of this invention is to provide a kind of pure and impure malicious granule and preparation method of dispelling, improve the quality of products, increase the stability of product, make that the patient is more pleased to take to satisfy needs of medical treatment better.

The objective of the invention is such realization:

Pure and impure malicious granule and the preparation method of dispelling comprises the steps:

One, the pure and impure malicious particulate prescription of dispelling is formed

Herba lygodii 1600g Caulis Sargentodoxae 4000g Herba Taraxaci 3200g

Cortex Moutan 800g Rhizoma Polygoni Cuspidati 800g Radix Rehmanniae 800g

Fructus Corni 800g Rhizoma Dioscoreae 800g Poria 800g

Rhizoma Alismatis 800g Herba Leonuri 800g Radix Astragali 800g

Right amount of auxiliary materials is made 1000 bags altogether.

Two, the pure and impure malicious granule preparing process of dispelling

Technology one cleans 12 flavor medicines respectively, removes impurity, and it is standby to be up to the standards; Get seven flavors such as Cortex Moutan, Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, the Radix Astragali and be ground into fine powder; Ground spices such as all the other Herba lygodii are broken into coarse powder or decoction pieces decocts with water 2-3 time, and each 1-3 hour, filter, filtrate is concentrated into the thick paste that relative density is 1.08-1.30 (80 ℃),, granulates drying, packing, quality inspection, packing with above-mentioned fine powder and auxiliary materials and mixing.

Technology two cleans 12 flavor medicines respectively, removes impurity, and it is standby to be up to the standards; Get seven flavors such as Cortex Moutan, Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, the Radix Astragali and be ground into fine powder; Ground spices such as all the other Herba lygodii are broken into coarse powder or decoction pieces decocts with water three times, each 1-3 hour, filter, filtrate is concentrated into the concentrated solution that relative density is 1.05-1.15 (60 ℃), spray drying, collect dried cream powder, add above-mentioned fine powder and appropriate amount of auxiliary materials mixing, granulate, dry, packing, quality inspection, packing.

Three, prepared by technology one, two is granule.

Adding adjuvant in the technology can be 30 POVIDONE K 30 BP/USP ₃₀, any or multiple mixing in the micropowder silica gel, sucrose, carmethose, starch, dextrin, Aspartane, magnesium stearate, essence uses.Seven flavor medicine material such as Cortex Moutan is broken into fine powder and was generally 80-160 purpose fine powder in the technology, is preferably superfine powder and is broken into 200-300 order fine powder.

Five tastes medical material such as all the other Herba lygodii is ground into coarse powder and was generally 5-30 purpose coarse powder/decoction pieces in the technology, is preferably 10 order coarse powder.

The condition that decocting boils in the technology is: decoct 2-3 time, amount of water is doubly measured for the 6-12 of dose for the first time, and second and third time doubly measured the each 1-3 of decocting time hour for the 4-10 of dose; The best is: decoct 3 times, amount of water is 10 times of amounts of dose for the first time, and second and third time is 8 times of amounts of dose, each 2 hours.

The relative density that is condensed into thick paste in the technology is 1.08-1.30 (80 ℃), and best relative density is 1.15-1.18 (80 ℃).

The relative density that is condensed into concentrated solution in the technology is 1.05-1.15 (60 ℃), and best relative density is 1.08-1.10 (60 ℃).

The spray drying inlet temperature is 100-200 ℃ in the technology, and leaving air temp is 50-150 ℃, and best inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.

The temperature of particle drying is controlled at 50-80 ℃ in the technology, is preferably 60 ℃.

The quality control of this product mainly is discriminating, inspection, three aspects of assay, increases the thin layer of Cortex Moutan, Rhizoma Polygoni Cuspidati, Herba Leonuri, the Radix Astragali in the prescription is differentiated; To heavy metal must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths limit examine.

This invention its superiority compared with the prior art is: production technology is simpler and reasonable, quality standard further improves, and makes the quality of product that guarantee arranged.

The specific embodiment

The optimum implementation of this invention is that 12 flavor medicines are cleaned respectively, removes impurity, and it is standby to be up to the standards; Get seven flavors such as Cortex Moutan, Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, the Radix Astragali and be ground into fine powder; Ground spices such as all the other Herba lygodii are broken into coarse powder or decoction pieces decocts with water 2-3 time, and each 1-3 hour, filter, filtrate is concentrated into the thick paste that relative density is 1.08-1.30 (80 ℃),, granulates drying, packing, quality inspection, packing with above-mentioned fine powder and auxiliary materials and mixing.

Claims

1, a kind of pure and impure malicious granule and preparation method of dispelling is characterized in that it may further comprise the steps:

(1) Cortex Moutan, Radix Rehmanniae, Fructus Corni, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis, Radix Astragali seven flavor medicine material are broken into fine powder and were generally 80-160 purpose fine powder in the technology, are preferably superfine powder and are broken into 200-300 order fine powder.

(2) Herba lygodii, Caulis Sargentodoxae, Herba Taraxaci, Rhizoma Polygoni Cuspidati, Herba Leonuri five tastes medical material are ground into coarse powder and were generally 5-30 purpose coarse powder/decoction pieces in the technology, are preferably 10 order coarse powder and decoct with water.

(3) condition that decocting boils in the technology is: decoct 2-3 time, amount of water is doubly measured for the 6-12 of dose for the first time, and second and third time doubly measured the each 1-3 of decocting time hour for the 4-10 of dose; The best is: decoct 3 times, amount of water is 10 times of amounts of dose for the first time, and second and third time is 8 times of amounts of dose, each 2 hours, concentrates then.

(4) relative density that is condensed into thick paste in the technology is 1.08-1.30 (80 ℃), and best relative density is 1.15-1.18 (80 ℃).

(5) relative density that is condensed into concentrated solution in the technology is 1.05-1.15 (60 ℃), and best relative density is 1.08-1.10 (60 ℃), carries out spray drying.

(6) the spray drying inlet temperature is 100-200 ℃ in the technology, and leaving air temp is 50-150 ℃, and best inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.

(7) temperature of particle drying is controlled at 50-80 ℃ in the technology, is preferably 60 ℃.

(8) adding adjuvant in the technology can be 30 POVIDONE K 30 BP/USP ₃₀, any/multiple mixing in the micropowder silica gel, sucrose, carmethose, starch, dextrin, Aspartane, magnesium stearate, essence uses.

(9) the standby composition with above-mentioned (1), (2), (3), (4), (5), (6), (7), (8) feeds intake by national standard prescription consumption, adds auxiliary materials and mixing, granulates, and the pure and impure malicious granule of dispelling is made in packing.

2, pure and impure malicious granule and the preparation method of dispelling according to claim 1 is characterized in that having the thin layer of pair Cortex Moutan, Rhizoma Polygoni Cuspidati, Herba Leonuri, the Radix Astragali to differentiate, has that heavy metal must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit examine.