CN1537576A - Jinjia paishi granule for discharging calculus, and its prepn. method - Google Patents
Jinjia paishi granule for discharging calculus, and its prepn. method Download PDFInfo
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- CN1537576A CN1537576A CNA031182828A CN03118282A CN1537576A CN 1537576 A CN1537576 A CN 1537576A CN A031182828 A CNA031182828 A CN A031182828A CN 03118282 A CN03118282 A CN 03118282A CN 1537576 A CN1537576 A CN 1537576A
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Abstract
An improved Chinese medicine 'jinjia lithagogue granule' for treating urolithiasis is prepared through pulverizing part of raw materials, extracting part of raw materials in alcohol, decocting the rest, collecting all together, drying adding auxiliary and fine powder, granulating and drying. Its advantages are quickly taking its effect, high curative effect and high safety.
Description
Technical field
This invention relates to the particulate processing technology technical field of Chinese patent medicine, relates in particular to tortoise beetle PAISHI KELI and preparation method.
Background technology
Granule is the pharmaceutical formulation of using always, according to the relevant drug act of China, change dosage form as a kind of new drug research, original dosage form of tortoise beetle PAISHI KELI is the tortoise beetle lithagogue pill, has listed in national Bureau of Drugs Supervision's country's standard for traditional Chinese medicines compilation (terrestrial reference rises the GB tentative standard).The technology characteristics of former dosage form is: eight flavors such as Radix Paeoniae Rubra are ground into fine powder in the ten Six-element medicines, and eight flavors such as all the other rhizoma sparganic are made the decocting dried cream powder, mixing then, encapsulated forming.Big 5 large capsule of this capsule dose, dysphagia is especially to old person, and this pharmaceutically dosage form is single, far can not satisfy people's medication demand, its quality standard still can further improve simultaneously, based on this, we use the modern pharmaceutical technology this product technology are done necessary improvement, form new preparation, the control criterion that improves the quality simultaneously guarantees the quality monitoring of product, improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of tortoise beetle PAISHI KELI and preparation method, improve the quality of products and curative effect, increase the stability of product, enrich medicine variety, to satisfy and to ensure people's medication demand better.
1, the preparation method of tortoise beetle PAISHI KELI comprises the steps:
1.1 the prescription of tortoise beetle PAISHI KELI is formed
Rhizoma sparganic (system) 275g Myrrha (stir-fry) 165g Radix Paeoniae Rubra 275g Semen Persicae (system) 165g
Spina Gleditsiae 165g Radix Angelicae Dahuricae 110g Fructus Aurantii (parched) 165g Rhizoma Curcumae 275g
Pericarpium Citri Reticulatae Viride 165g Olibanum (stir-fry) 165g Semen Coicis 275g Radix Cyathulae 165g
Semen Plantaginis 275g Cortex Magnoliae Officinalis 110g Squama Manis (system) 55g Herba Desmodii Styracifolii 550g
Right amount of auxiliary materials is made 1000 bags altogether.
1.2 the preparation technology of tortoise beetle PAISHI KELI
Technology one, will write out a prescription in ten Six-element medicines be up to the standards standby respectively; Radix Paeoniae Rubra, Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Angelicae Dahuricae, Semen Coicis, Olibanum, Myrrha are ground into fine powder, and be standby; Eight flavors such as all the other rhizoma sparganic are ground into coarse powder or decoction pieces, decoct with water 2-3 time, each 1-4 hour, filter merging filtrate, being concentrated into relative density is the thick paste of 1.15-1.45 (80 ℃), and drying is ground into fine powder, with above-mentioned fine powder and appropriate amount of auxiliary materials mixing, granulates, drying, granulate, packing, promptly.
Technology two, will write out a prescription in ten Six-element medicines be up to the standards standby respectively; Olibanum, Myrrha are ground into fine powder, and be standby; Radix Paeoniae Rubra, Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Angelicae Dahuricae extract 2-3 time with the 60-95% alcohol heating reflux, and each 1-3 hour, extracting solution reclaimed ethanol, are concentrated into an amount of, standby; Nine flavors such as all the other rhizoma sparganic decoct with water 2-3 time, and each 1-4 hour, filter, merging filtrate is concentrated into an amount of, merge with above-mentioned alcohol extract, vacuum drying/spray drying is made dried cream powder, with above-mentioned fine powder and appropriate amount of auxiliary materials mixing, granulates, drying, granulate, packing, promptly.
1.3 by the technology gained is granule
The added adjuvant of tortoise beetle PAISHI KELI can be: 30 POVIDONE K 30 BP/USP
30, any or multiple mixing in the micropowder silica gel, starch, dextrin, sucrose, steviosin, Aspartane, magnesium stearate, essence etc. uses.
Need be ground into the medical material of fine powder in the technology, can routine be ground into 80-160 purpose fine powder or superfine powder is broken into 200-300 purpose fine powder.
Be ground into coarse powder in the technology or make decoction pieces and be generally 5-40 purpose coarse powder/decoction pieces, be preferably 10-20 order coarse powder.
The condition that decocting boils in the technology is: amount of water is that 6-15 doubly measures for the first time, and second and third time doubly measured for 4-10, decocts each 1-4 hour 2-3 time.Best amount of water is 10 times of amounts for the first time in order to decoct secondary, is 8 times of amounts for the second time, decocts 2 hours for the second time 3 hours for the first time.
The reflux condition is in the technology two: the ethanol with 60-95% is molten, and the solubilizer flow control is once doubly measured for 6-14, and second and third time doubly measured for 4-12, reflux 2-3 time, each 1-3 hour.The best thinks that 70% ethanol is solvent, and the solubilizer flow control once is 10 times of amounts, is 8 times of amounts for the second time, refluxes each 2 hours 2 times.
The relative density of thick paste is 1.15-1.45 (80 ℃) in the technology, and best relative density is 1.36-1.38 (80 ℃).
Drying can adopt vacuum drying or spray drying in the technology.The vacuum drying temperature is controlled at 50-90 ℃, and the best is 60 ℃.Spray drying is for to be condensed into the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100-200 ℃, leaving air temp is 50-150 ℃, best relative density is 1.08-1.12 (60 ℃), and inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.Particle drying adopts vacuum drying.
Extracting solution filters and also can adopt centrifugation method in the technology.
Concentrate in the technology and can adopt concentrating under reduced pressure or thin film concentration.
2, the quality control standard of tortoise beetle PAISHI KELI further improves on the basis of original tortoise beetle lithagogue pill among the present invention, on differentiating, increased Olibanum, Myrrha, the Radix Angelicae Dahuricae have been carried out the thin layer discriminating, former dosage form does not have the limit examine of arsenic salt, heavy metal on checking, now increased heavy metal limit and must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths.
This invention is dosage form technological innovation on existing capsular basis, and quality standard has new raising again, to improving the quality of products significant meaning is arranged, and has enriched medicine variety, satisfies and ensured people's medication demand.
The specific embodiment
This invention optimum implementation is: ten Six-element medicines are up to the standards standby respectively in will writing out a prescription; Olibanum, Myrrha are ground into fine powder, and be standby; Radix Paeoniae Rubra, Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Angelicae Dahuricae extract 2 times with 70% alcohol heating reflux, and each 2 hours, extracting solution reclaimed ethanol, and it is standby to be concentrated into relative density 1.08-1.10 (60 ℃); Nine flavors such as all the other rhizoma sparganic decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time, filter, merging filtrate is concentrated into relative density 1.08-1.10 (60 ℃), merge with above-mentioned alcohol extract, spray drying is made dried cream powder, with above-mentioned fine powder and appropriate amount of auxiliary materials mixing, granulates, dry, granulate, packing, promptly.
Claims (8)
1, a kind of tortoise beetle PAISHI KELI and preparation method is characterized in that:
(1) will write out a prescription in ten Six-element medicines be up to the standards standby respectively; Radix Paeoniae Rubra, Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Angelicae Dahuricae, Semen Coicis, Olibanum, Myrrha are ground into fine powder, and be standby; All the other rhizoma sparganic, Semen Persicae, Spina Gleditsiae, Rhizoma Curcumae, Radix Cyathulae, Semen Plantaginis, Squama Manis, Herba Desmodii Styracifolii eight flavors are ground into coarse powder/decoction pieces, decoct with water each 1-4 hour 2-3 time, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.15-1.45 (80 ℃), dry, be ground into fine powder,, granulate with above-mentioned fine powder and appropriate amount of auxiliary materials mixing, dry, granulate, packing makes the tortoise beetle PAISHI KELI.
(2) will write out a prescription in ten Six-element medicines be up to the standards standby respectively; Olibanum, Myrrha are ground into fine powder, and be standby; Radix Paeoniae Rubra, Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae Viride, the Radix Angelicae Dahuricae extract 2-3 time with the 60-95% alcohol heating reflux, and each 1-3 hour, extracting solution reclaimed ethanol, are concentrated into an amount of, standby; All the other rhizoma sparganic, Semen Persicae, Spina Gleditsiae, Rhizoma Curcumae, Radix Cyathulae, Semen Plantaginis, Squama Manis, Herba Desmodii Styracifolii, Semen Coicis nine flavors decoct with water 2-3 time, each 1-4 hour, filter, merging filtrate, be concentrated in right amount, merge with above-mentioned alcohol extract, vacuum drying/spray drying is made dried cream powder, with above-mentioned fine powder and appropriate amount of auxiliary materials mixing, granulate drying, granulate, packing, promptly.
2, tortoise beetle PAISHI KELI according to claim 1 and preparation method is characterized in that: the added adjuvant of tortoise beetle PAISHI KELI can be: 30 POVIDONE K 30 BP/USP
30, any/multiple mixing in the micropowder silica gel, starch, dextrin, sucrose, steviosin, Aspartane, magnesium stearate, essence etc. uses.
3, tortoise beetle PAISHI KELI according to claim 1 and preparation method, it is characterized in that: the medical material that need be ground into fine powder in the technology, can routine be ground into 80-160 purpose fine powder/superfine powder and be broken into 200-300 purpose fine powder, be ground into coarse powder in the technology or make decoction pieces and be generally 5-40 purpose coarse powder/decoction pieces, be preferably 10-20 order coarse powder.
4, tortoise beetle PAISHI KELI according to claim 1 and preparation method, it is characterized in that: the condition that decocting boils in the technology is: amount of water is that 6-15 doubly measures for the first time, and second and third time doubly measured for 4-10, decocts each 1-4 hour 2-3 time.Best amount of water is 10 times of amounts for the first time in order to decoct secondary, is 8 times of amounts for the second time, decocts 2 hours for the second time 3 hours for the first time.
5, tortoise beetle PAISHI KELI according to claim 1 and preparation method, it is characterized in that: the reflux condition is in the technology two: the ethanol with 60-95% is molten, the solubilizer flow control is once doubly measured for 6-14, and second and third time doubly measured for 4-12, reflux 2-3 time, each 1-3 hour, the best thinks that 70% ethanol is solvent, and the solubilizer flow control once is 10 times of amounts, is 8 times of amounts for the second time, reflux each 2 hours 2 times.
6, tortoise beetle PAISHI KELI according to claim 1 and preparation method is characterized in that: the relative density of thick paste is 1.15-1.45 (80 ℃) in the technology, and best relative density is 1.36-1.38 (80 ℃).
7, tortoise beetle PAISHI KELI according to claim 1 and preparation method, it is characterized in that: drying can adopt vacuum drying/spray drying in the technology, and the vacuum drying temperature is controlled at 50-90 ℃, and the best is 60 ℃.Spray drying is for to be condensed into the concentrated solution that relative density is 1.05-1.15 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100-200 ℃, leaving air temp is 50-150 ℃, best relative density is 1.08-1.12 (60 ℃), and inlet temperature is 160-180 ℃, and leaving air temp is 80-100 ℃.Particle drying adopts vacuum drying.
8, tortoise beetle PAISHI KELI according to claim 1 and preparation method, it is characterized in that: on quality inspection standard, have the thin layer of Olibanum, Myrrha, the Radix Angelicae Dahuricae to differentiate, have heavy metal limit must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031182828A CN1537576A (en) | 2003-04-15 | 2003-04-15 | Jinjia paishi granule for discharging calculus, and its prepn. method |
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| CNA031182828A CN1537576A (en) | 2003-04-15 | 2003-04-15 | Jinjia paishi granule for discharging calculus, and its prepn. method |
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| CN1537576A true CN1537576A (en) | 2004-10-20 |
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| CNA031182828A Pending CN1537576A (en) | 2003-04-15 | 2003-04-15 | Jinjia paishi granule for discharging calculus, and its prepn. method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657826A (en) * | 2012-06-03 | 2012-09-12 | 王光华 | Medicine used for treating renal calculus and preparation method thereof |
| CN103394035A (en) * | 2013-08-05 | 2013-11-20 | 刘建飞 | Traditional Chinese medicine composition used for treating urinary calculus |
| CN107753875A (en) * | 2017-11-26 | 2018-03-06 | 孙国安 | It is a kind of to be used for anti-inflammatory, spasmolysis, analgesic, diuresis, the medicine and preparation method for arranging stone |
-
2003
- 2003-04-15 CN CNA031182828A patent/CN1537576A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657826A (en) * | 2012-06-03 | 2012-09-12 | 王光华 | Medicine used for treating renal calculus and preparation method thereof |
| CN103394035A (en) * | 2013-08-05 | 2013-11-20 | 刘建飞 | Traditional Chinese medicine composition used for treating urinary calculus |
| CN103394035B (en) * | 2013-08-05 | 2015-11-18 | 范海燕 | A kind of Chinese medicine composition for the treatment of urinary system calculus |
| CN107753875A (en) * | 2017-11-26 | 2018-03-06 | 孙国安 | It is a kind of to be used for anti-inflammatory, spasmolysis, analgesic, diuresis, the medicine and preparation method for arranging stone |
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