CN101700323B - Pharmaceutical composition for preventing and treating liver cancer - Google Patents
Pharmaceutical composition for preventing and treating liver cancer Download PDFInfo
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- CN101700323B CN101700323B CN200910154495.2A CN200910154495A CN101700323B CN 101700323 B CN101700323 B CN 101700323B CN 200910154495 A CN200910154495 A CN 200910154495A CN 101700323 B CN101700323 B CN 101700323B
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- pharmaceutical composition
- radix
- spore powder
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- ganoderma lucidum
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Abstract
The invention discloses a pharmaceutical composition for treating liver cancer and a prepration method thereof. The pharmaceutical composition consists of ganoderma wall-broken spore powder, hemsley rockvine root, spreading hedyotis herb, barbed skullcap herb, kiwi root, wild grape root and other components. The preparation method comprises the following steps: weighing all the raw materials according to the proportion of a formula, smashing and grinding the medicines except the ganoderma wall-broken spore powder into coarse powder, carrying out water decoction twice with 3 hours for the first time and 2 hours for the second time, filtering, concentrating filtrate into a thick paste, drying, smashing, passing through a 100-mesh sieve, adding the ganoderma wall-broken spore powder, mixing evenly, wetting, softening, taking out when forming clumps, and preparing into granules. The prepared compound preparation adopts the oral formulation, thereby having convenient use and good taste and being easy to be accepted by a patient. The pharmaceutical composition actually has the effects of strengthening body resistance, promoting blood circulation, removing blood stasis, clearing heat-toxin, inducing diuresis and removing edema, can well play the role of treating the liver cancer or relieving symptoms, and has the advantages of good efficacy, short period, low price, on side effects and convenient administration for the patient, thereby being an effective drug which is easy to be accepted by the patient and used for preventing and treating the cancer liver.
Description
Technical field
The present invention relates to Chinese patent medicine, be specifically a kind of take that Chinese medicine is main component prevent and treat pharmaceutical composition of hepatocarcinoma and preparation method thereof.
Background technology
Hepatocarcinoma is a kind of of cancer, is one of main disease causing mankind's death, at present temporarily without specific drug and specific treatment method.The operation of doctor trained in Western medicine can be excised rapidly early, mid-term cancer, but often easily recurrence; Simultaneously, to a patient who suffers from hepatocarcinoma, operation technique can emit lethal danger, because he also suffers from quite serious hepatitis interstitialis chronica, although be a better Therapeutic Method if use in the case good anticancer preparation. radiotherapy can make cancer cell atrophy, degeneration, but can only carry out topical therapeutic, and accommodator only accounts for 20%; Though chemotherapy can be carried out whole body therapeutic, patient is often because toxic and side effects and untoward reaction seriously cannot be persevered.In order to solve the deficiency of above-mentioned technology, the present invention is through scientific composition, and development, provides a kind of anticancer Chinese medicine preparation and preparation method thereof meticulously.It can be cured the disease, again can diseases prevention, and therapeutic effect is good, and patient Le Yi accepts.Meanwhile, fatty liver and hepatitis interstitialis chronica are also had to good prevention effect, can effectively stop the development of hepatocarcinoma and be used for the treatment of hepatocarcinoma.
Summary of the invention
The pure Chinese medicinal preparation that the object of this invention is to provide a kind of Hepatoma therapy.It follows the principle of the traditional Chinese medical science " sthenia syndrome requiring purgation " and " deficiency syndrome should be treated by tonifying method ", there is the effect of strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, inducing diuresis to remove edema, aim to provide and a kind ofly can either play fine treatment or relief of symptoms effect to hepatocarcinoma, there is good effect, the cycle is short, price is low, without any untoward reaction, patient can be continuously, long-term prescription and be unlikely to produce the toxic and side effects of the organ injuries such as bone marrow depression, granulocytopenia, liver and kidney; Medication is convenient, economical, is only equivalent to 25% of chemotherapeutics expense, is a kind of anticancer Chinese medicine composition that patient takes like a shot.It all has good effect to all kinds of hepatocarcinoma of early, middle and late phase.
The present invention develops Chinese medicine composition meticulously according to traditional Chinese medical science prescription and preparation principle, by following technical scheme, realizes:
The consumption of drug component of the present invention is groped in a large number to sum up through inventor and is drawn, each amounts of components has good curative effect in following ranges, and medicine of the present invention contains:
Sporoderm-broken Ganoderma Lucidum Spore powder 331-999 part Radix Apioris Fortunei (Radix Lespedezae Buergeri) 166-498 part Radix vitis romanetii 166-498 part
Herba Hedyotidis Diffusae 166-998 part Herba Scutellariae Barbatae 166-498 part Radix Actinidiae Chinensis 166-498 part
The preparation method of described pharmaceutical composition comprises the steps:
Take in proportion each raw material, except Sporoderm-broken Ganoderma Lucidum Spore powder, said medicine is pulverized and is ground into coarser powder, decocting secondary, 3 hours for the first time, 2 hours for the second time, filter, filtrate is condensed into thick paste, dry, pulverize 100 mesh sieves, added Sporoderm-broken Ganoderma Lucidum Spore powder, mix, moistening, soften, take out granulation electuary while forming agglomerate.
Object of the present invention can also take following methods to realize:
Its formula optimization is:
333 parts of 333 parts of Radix vitis romanetiis of 666 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Sporoderm-broken Ganoderma Lucidum Spore powder
333 parts of 333 parts of Radix Actinidiae Chinensiss of 666 portions of Herba Scutellariae Barbataes of Herba Hedyotidis Diffusae
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not;
The present invention is by scientific combination, development meticulously, there is the effect of strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, inducing diuresis to remove edema, can play fine treatment or relief of symptoms effect to hepatocarcinoma, there is good effect, the cycle is short, price is low, without any untoward reaction, patient's medication is convenient, economical, only be equivalent to 25% of chemotherapeutics expense, can be continuously, long-term prescription and be unlikely to produce the toxic and side effects of the organ injuries such as bone marrow depression, granulocytopenia, liver and kidney; All kinds of hepatocarcinoma of early, middle and late phase is all had to good effect, is a kind of anticancer Chinese medicine composition that patient takes like a shot.
Medicine of the present invention can adopt Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverize mix homogeneously can be made to powder takes after mixing it with water; Also can be by these medicines together decocting, then, condensed water decocting liquid, makes peroral dosage form; But can not limit the scope of the invention.
The specific embodiment
Below in conjunction with embodiment, describe implementation of the present invention in detail.
Embodiment 1:
The preparation method of granule of the present invention:
Take in proportion each raw material, 666 grams of Sporoderm-broken Ganoderma Lucidum Spore powder, Radix Apioris Fortunei (Radix Lespedezae Buergeri) grams 333 grams, 333 grams of Radix vitis romanetiis, Herba Hedyotidis Diffusae grams 666 grams, Herba Scutellariae Barbatae grams 333 grams, Radix Actinidiae Chinensis grams 333 grams.
Except Sporoderm-broken Ganoderma Lucidum Spore powder, said medicine is pulverized and is ground into coarser powder, decocting secondary, 3 hours for the first time, 2 hours for the second time, filter, filtrate is condensed into thick paste, dry, pulverized 100 mesh sieves, add Sporoderm-broken Ganoderma Lucidum Spore powder, mix, moistening, soften, take out granulation electuary while forming agglomerate.
Embodiment 2:
The preparation method of syrup of the present invention: take in proportion each raw material, 666 grams of Sporoderm-broken Ganoderma Lucidum Spore powder, 333 grams of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s, 333 grams of Radix vitis romanetiis, 666 grams of Herba Hedyotidis Diffusaes, 333 grams of Herba Scutellariae Barbataes, 333 grams of Radix Actinidiae Chinensiss.Except Sporoderm-broken Ganoderma Lucidum Spore powder, said medicine is pulverized and is ground into coarser powder, decocting secondary, each 2 hours, filter merging filtrate, be condensed into thick paste, add ethanol precipitation secondary, make once to reach 65% containing alcohol flow control, reach for the second time 80%, filter, reclaim ethanol and be concentrated into about 700mL, with sucrose, ethyl hydroxybenzoate alcohol liquid, stir molten while hot, add again boiling water to full dose, stir evenly and obtain and make syrup.
Embodiment 3:
The preparation method of tablet of the present invention:
By 555 grams of Sporoderm-broken Ganoderma Lucidum Spore powder, Radix Apioris Fortunei (Radix Lespedezae Buergeri) grams 345 grams, 345 grams of Radix vitis romanetiis, 555 grams of Herba Hedyotidis Diffusaes, Herba Scutellariae Barbatae grams 345 grams, 345 grams of Radix Actinidiae Chinensiss.Except Sporoderm-broken Ganoderma Lucidum Spore powder, said medicine is pulverized and is ground into slightly not, after example 1 method granulation, add appropriate additives, mix, tabletting, coating, make suitable tablet.
In like manner, by the method for embodiment 1, add suitable capsule etc.
Preparation of the present invention is fragrant faint yellow granule, sepia syrup or tablet or capsule.
During each forms above, weight is calculated with crude drug, in the present invention, if weight in grams, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses, the final drug preparation of making, as make 1000 of 1000 of capsule preparations, 1000, tablet, granule 1000g, oral liquid 1000 ampullas, injection 1000 ampullas, drop pill etc., as granule, also can make large packing, as 100-500 bag, can be specifically 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but each raw medicinal herbs weight proportion constant rate between forming.
For a better understanding of the present invention, below further set forth medicine of the present invention at the action effect of pharmacology and clinical research, but not restriction to effect of the present invention.
Selection of clinical is observed 30 routine liver cancer patients, is divided into 2 groups, every group of 15 examples.Matched group adopts Treated with Tian-Xian-Wan Pills, and treatment group adopts the treatment of this medicine.Clinical effectiveness is as follows:
According to above clinical pharmacology result of study, the present invention has the effect of strengthening the body resistance, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, inducing diuresis to remove edema really, can play fine treatment or relief of symptoms effect to hepatocarcinoma, there is good effect, the cycle is short, price is low, without any untoward reaction, patient's medication is convenient, economical, only be equivalent to 25% of chemotherapeutics expense, can be continuously, long-term prescription and be unlikely to produce the toxic and side effects of the organ injuries such as bone marrow depression, granulocytopenia, liver and kidney; All kinds of hepatocarcinoma of early, middle and late phase is all had to good effect, is a kind of active drug of preventing and treating hepatocarcinoma that patient takes like a shot.
Claims (7)
1. prevent and treat a pharmaceutical composition for hepatocarcinoma, it is characterized in that it is comprised of as active component and pharmaceutically acceptable additives Sporoderm-broken Ganoderma Lucidum Spore powder, other following raw materials according water extract, the weight portion of each raw material is:
Sporoderm-broken Ganoderma Lucidum Spore powder 331-999 part Radix Apioris Fortunei (Radix Lespedezae Buergeri) 166-498 part Radix vitis romanetii 166-498 part
Herba Hedyotidis Diffusae 166-998 part Herba Scutellariae Barbatae 166-498 part Radix Actinidiae Chinensis 166-498 part
2. pharmaceutical composition according to claim 1, optimum weight part is:
333 parts of 333 parts of Radix vitis romanetiis of 666 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s of Sporoderm-broken Ganoderma Lucidum Spore powder,
222 parts of 222 parts of Radix Actinidiae Chinensiss of 666 portions of Herba Scutellariae Barbataes of Herba Hedyotidis Diffusae
3. pharmaceutical composition according to claim 1, is characterized in that: described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, dried starch, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate.
4. the preparation method of pharmaceutical composition according to claim 1, is characterized in that comprising the steps:
Take in proportion each raw material, except Sporoderm-broken Ganoderma Lucidum Spore powder, said medicine is pulverized and is ground into coarser powder, decocting secondary, 3 hours for the first time, 2 hours for the second time, filter, filtrate is condensed into extractum, dry, pulverize 100 mesh sieves, added Sporoderm-broken Ganoderma Lucidum Spore powder, mix, moistening, soften, take out granulation electuary while forming agglomerate.
5. pharmaceutical composition according to claim 1, is characterized in that: its dosage form is effervescent granule electuary, capsule or tablet;
6. pharmaceutical composition according to claim 5, is characterized in that described capsule is effervescent capsule;
7. pharmaceutical composition according to claim 5, is characterized in that, described tablet can be effervescent tablet or dispersible tablet, with suitable coating material coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910154495.2A CN101700323B (en) | 2009-10-30 | 2009-10-30 | Pharmaceutical composition for preventing and treating liver cancer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910154495.2A CN101700323B (en) | 2009-10-30 | 2009-10-30 | Pharmaceutical composition for preventing and treating liver cancer |
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| Publication Number | Publication Date |
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| CN101700323A CN101700323A (en) | 2010-05-05 |
| CN101700323B true CN101700323B (en) | 2014-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200910154495.2A Expired - Fee Related CN101700323B (en) | 2009-10-30 | 2009-10-30 | Pharmaceutical composition for preventing and treating liver cancer |
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| CN109170592A (en) * | 2018-10-22 | 2019-01-11 | 中南民族大学 | A kind of radix tetrastigme polysaccharide liver protection dilated food and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265314A (en) * | 2000-01-25 | 2000-09-06 | 邓云飞 | Liver-invigorating detoxication pill for treating hepatitis B |
| CN1336186A (en) * | 2000-07-28 | 2002-02-20 | 雷学军 | Antineoplastic functional water containing natural medicine component and its compounding process |
| CN1899574A (en) * | 2006-06-30 | 2007-01-24 | 杨熠锴 | Chinese medicine composition for preventing and controlling liver cancer and its use |
-
2009
- 2009-10-30 CN CN200910154495.2A patent/CN101700323B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265314A (en) * | 2000-01-25 | 2000-09-06 | 邓云飞 | Liver-invigorating detoxication pill for treating hepatitis B |
| CN1336186A (en) * | 2000-07-28 | 2002-02-20 | 雷学军 | Antineoplastic functional water containing natural medicine component and its compounding process |
| CN1899574A (en) * | 2006-06-30 | 2007-01-24 | 杨熠锴 | Chinese medicine composition for preventing and controlling liver cancer and its use |
Non-Patent Citations (6)
| Title |
|---|
| 张杲等.金国梁辨治肿瘤经验介绍.《山西中医》.2008,第24卷(第10期), |
| 林志彬等.灵芝孢子及其活性成分的药理研究.《北京大学学报(医学版)》.2006,第38卷(第05期), |
| 灵芝孢子及其活性成分的药理研究;林志彬等;《北京大学学报(医学版)》;20061031;第38卷(第05期);541-547 * |
| 王静雯.齐鲁灵芝破壁孢子粉配合奇宁注射液治疗恶性肿瘤28例副反应观察及护理.《齐鲁护理杂志》.2007,第13卷(第17期), |
| 金国梁辨治肿瘤经验介绍;张杲等;《山西中医》;20081031;第24卷(第10期);4-5 * |
| 齐鲁灵芝破壁孢子粉配合奇宁注射液治疗恶性肿瘤28例副反应观察及护理;王静雯;《齐鲁护理杂志》;20070930;第13卷(第17期);第2页第2栏第2段 * |
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| CN101700323A (en) | 2010-05-05 |
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Owner name: ZHEJIANG PHARMACEUTICAL COLLEGE Free format text: FORMER OWNER: YANG XIONGZHI Effective date: 20131230 |
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Free format text: CORRECT: ADDRESS; FROM: 315040 NINGBO, ZHEJIANG PROVINCE TO: 315100 NINGBO, ZHEJIANG PROVINCE |
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Effective date of registration: 20131230 Address after: 315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Applicant after: Zhejiang Pharmaceutical College Address before: 315040 Zhejiang city of Ningbo Province Higher Education Park East Yinxian Avenue No. 888 Applicant before: Yang Xiongzhi |
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