CN1899425B - Chinese medicine composition for treating emmeniopathy - Google Patents
Chinese medicine composition for treating emmeniopathy Download PDFInfo
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- CN1899425B CN1899425B CN2006100522435A CN200610052243A CN1899425B CN 1899425 B CN1899425 B CN 1899425B CN 2006100522435 A CN2006100522435 A CN 2006100522435A CN 200610052243 A CN200610052243 A CN 200610052243A CN 1899425 B CN1899425 B CN 1899425B
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Abstract
The present invention discloses a kind of Chinese medicine composition for treating emmeniopathy. The Chinese medicine composition is granule prepared with loosestrife, motherwort, angelica, Japanese raspberry root, bracken, madder and other Chinese medicine materials, and through reflux extracting angelica and motherwort with 70-95 % alcohol solution, concentrating and drying to obtain extractum I; decocting all the Chinese medicine materials including alcohol extracted residue, concentrating and drying to obtain extractum II, merging the extractum I and the extractum II; and further steps. The Chinese medicine composition possesses functions of benefiting qi, nourishing blood, promoting blood circulation to regulate menstruation, dissipating blood stasis and relieving pain; is used in treating abnormal menstruation, dysmenorrheal and other emmeniopathy, and has the advantages of high curative effect, low cost, no toxic side effect, etc.
Description
Technical field
The present invention relates to field of medicaments, is a kind of Chinese medicine composition for the treatment of menopathy specifically
Background technology
The inflammation of menoxenia, dysmenorrhea, amenorrhea, various urogenital systems such as vaginitis, pelvic inflammatory disease, endometritis, adnexitis etc. are women's frequently-occurring disease and commonly encountered diseases in life.Relatively poor, diseases such as the weak easier trouble menopathy of women such as dysmenorrhea, menoxenia, amenorrhea, lochia after being ill of body constitution particularly.The menoxenia sickness rate is higher, often occupies first of the gynaecopathia.At present, doctor trained in Western medicine does not also have good treatment means to these diseases, this type of gynaecopathia of western medicine, and not only weak curative effect, easily recurrence, and also side effect is big.Particularly in order to the medicine of treatment women's diseases such as dysmenorrhea, amenorrhea, leukorrhagia, the very little or basic inefficacy of its curative effect has only by taking good care of slowly, and this brings very big inconvenience and misery to the women.
Summary of the invention
Purpose of the present invention overcomes exactly that the Western medicine side effect is big, curative effect not significantly or reason such as form of Chinese drug, the deficiency of technology such as curative effect instability, according to traditional Chinese medical science prescription and preparation principle to Chinese medicine composition advantages such as meticulously development provides a kind of pointed strong, good effect, the cycle is short, price is low, have no side effect, the patient is taken like a shot, can treat the pure Chinese medicinal preparation of menopathy preferably.It all has good effect to inflammation of menoxenia, dysmenorrhea, amenorrhea, various urogenital systems etc.This meets numerous doctors and patient's common aspiration fully.
The present invention develops Chinese medicine composition meticulously according to traditional Chinese medical science prescription and preparation principle, realizes by following technical scheme:
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
166～498 parts of 166～498 parts of Radix Angelicae Sinensis of 331～999 parts of Herba Leonuris of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
166～498 parts in 166～498 portions of Radix Rubiaes of 166～498 portions of Herba Pteridis Multifidaes of radix rubi parvifol
Preferable range is:
248～496 parts of 248～496 parts of Radix Angelicae Sinensis of 498～998 parts of Herba Leonuris of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
248～496 parts in 248～496 portions of Radix Rubiaes of 248～496 portions of Herba Pteridis Multifidaes of radix rubi parvifol
Optimum weight part is:
331 parts of 331 parts of Radix Angelicae Sinensis of 662 parts of Herba Leonuris of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
331 parts in 222 portions of Radix Rubiaes of 331 portions of Herba Pteridis Multifidaes of radix rubi parvifol
Technical problem to be solved by this invention is to realize by following technical scheme.Be characterized in that with Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Herba Leonuri, Radix Angelicae Sinensis, radix rubi parvifol, Herba Pteridis Multifidae, Radix Rubiae etc. be the medicine that raw material is made.The Chinese medicine composition of this treatment menopathy is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.The present invention is by scientific combination, development meticulously, effect with benefiting QI and nourishing blood, promoting blood flow to regulate menstruation, eliminating stasis to stop pain, have advantages such as good effect, the cycle is short, price is low, have no side effect, it all has good curative effect to various menstruation diseases such as gynecological's menoxenia, dysmenorrhea, amenorrheas.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably crude drug Radix Angelicae Sinensis, Herba Leonuri are carried out ethanol extraction, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine better bring into play drug effect.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation method of granule of the present invention: medicine of the present invention can prepare by the following method:
(a) take by weighing former medicines such as Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 500 grams, Herba Leonuri 500 grams, Radix Angelicae Sinensis 500 grams, radix rubi parvifol 250 grams, Herba Pteridis Multifidae 350, Radix Rubiae 250 grams and that coarser powder is ground in its pulverizing is standby by weight ratio;
(b) Radix Angelicae Sinensis, the Herba Leonuri with described weight proportion carries out reflux, extract, twice with 70%～95% ethanol, merges extracted twice liquid, reclaims ethanol, is condensed into proportion and is 1.15～1.35 extractum, 45～55 ℃ dry down, dry extract 1;
(c) Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), radix rubi parvifol, Herba Pteridis Multifidae, Radix Rubiae and the Radix Angelicae Sinensis of described weight proportion, the residue after the Herba Leonuri alcohol extraction are decocted with water twice, add water serves as easy not have powder at every turn, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, the active component of preparation cost invention medicine;
(e) with gained active component and pharmaceutically acceptable additives such as correctives, the abundant mixing of adjuvant, make any dosage form of pharmaceutics.As above-mentioned active component was pulverized 100 mesh sieves, with pharmaceutically acceptable additives such as mixings such as ethanol, starch, moistening, soften, take out when forming agglomerate, make dissolved granule.
In the above-mentioned preparation method, when in the preferred steps (b) medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, and add amount of alcohol the second time is 10 times, extracts 1 hour.(c) during with the medicine extracting in water, add 10 times in water for the first time in, decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours.
Embodiment 2:
The preparation method of syrup of the present invention:, each 1 hour, filter with Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 600 grams, Herba Leonuri 500 grams, Radix Angelicae Sinensis 450 grams, radix rubi parvifol 250 grams, Herba Pteridis Multifidae 250, Radix Rubiae 350 gram decocting secondaries, merging filtrate, be condensed into thick paste, add the ethanol precipitation secondary, make to contain pure flow control and once reach 65%, for the second time reach 80%, filter, reclaim ethanol and be concentrated into about 700mL, stir molten with sucrose, ethyl hydroxybenzoate alcohol liquid while hot, add boiling water again to full dose, stir evenly promptly to get and make syrup.
Embodiment 3:
The preparation method of tablet of the present invention:
The broken coarser powder that grind into of former medicated powder such as Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 500 grams, Herba Leonuri 400 grams, Radix Angelicae Sinensis 450 grams, radix rubi parvifol 250 grams, Herba Pteridis Multifidae 250 grams, Radix Rubiae 350 grams is standby; After making granule by example 1 method, add an amount of additives, mixing, tabletting, coating are made suitable tablet.
In like manner, press the method for embodiment 1, add suitable capsule etc.
Preparation of the present invention is fragrant faint yellow granule, sepia syrup or tablet or capsule.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as 100-500 bags, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
For a better understanding of the present invention, below further set forth the action effect of medicine of the present invention in pharmacology and clinical research, but not to the restriction of effect of the present invention.
Observe 128 routine patients, be divided into 2 groups.Matched group 60 examples adopt the treatment of control drug YANGXUE DANGGUI JING, and treatment group 68 examples adopt the treatment of this medicine, and clinical effectiveness is as follows:
According to above clinical effectiveness, the present invention is by scientific combination, development meticulously, really the effect that has benefiting QI and nourishing blood, promoting blood flow to regulate menstruation, eliminating stasis to stop pain, have advantages such as good effect, the cycle is short, price is low, have no side effect, it all has good curative effect to various menstruation diseases such as gynecological's menoxenia, dysmenorrhea, amenorrheas.
Claims (8)
1. Chinese medicine composition for the treatment of menopathy, it is characterized in that: it is by the water extract of following raw materials according or alcohol extract is made active component and pharmaceutically receptible additives are formed, and the weight portion of each raw material is: 248～496 parts in 248～496 portions of Radix Rubiaes of 248～496 portions of Herba Pteridis Multifidaes of 248～496 parts of radix rubi parvifols of 248～496 parts of Radix Angelicae Sinensis of 498～998 parts of Herba Leonuris of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).
2. a kind of Chinese medicine composition for the treatment of menopathy according to claim 1 is characterized in that: described pharmaceutically receptible additives are following more than one: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, dried starch, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin and sodium lauryl sulphate.
3. a kind of preparation method for the treatment of the Chinese medicine composition of menopathy according to claim 1 is characterized in that comprising the steps:
(a) take by weighing Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), radix rubi parvifol, Herba Pteridis Multifidae, Radix Rubiae and Herba Leonuri, the former medicine of Radix Angelicae Sinensis and that coarser powder is ground in its pulverizing is standby by weight;
(b) Radix Angelicae Sinensis, the Herba Leonuri with described weight proportion carries out reflux, extract, twice with 70%～95% ethanol, merges extracted twice liquid, reclaims ethanol, is condensed into proportion and is 1.15～1.35 extractum, 45～55 ℃ dry down, dry extract 1;
(c) Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), radix rubi parvifol, Herba Pteridis Multifidae, Radix Rubiae and the Radix Angelicae Sinensis of described weight proportion, the residue after the Herba Leonuri alcohol extraction are decocted with water twice, add water at every turn and do not have powder, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, be prepared into the active component of medicine;
(e) with gained active component and the abundant mixing of receptible additives pharmaceutically, make dissolved granule.
4. a kind of preparation method for the treatment of the Chinese medicine composition of menopathy according to claim 3, it is characterized in that: when in the described step (b) medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, for the second time adding amount of alcohol is 10 times, extracts 1 hour; Spissated extractum proportion is 1.15.
5. a kind of preparation method for the treatment of the Chinese medicine composition of menopathy according to claim 3 is characterized in that: during with the medicine extracting in water, add 10 times in water for the first time in the described step (c), decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours; Spissated extractum proportion is 1.20.
6. a kind of Chinese medicine composition for the treatment of menopathy according to claim 1 is characterized in that: its dosage form is effervescent granule electuary, capsule or tablet.
7. a kind of Chinese medicine composition for the treatment of menopathy according to claim 6 is characterized in that: described capsule is the effervescent capsule.
8. a kind of Chinese medicine composition for the treatment of menopathy according to claim 6 is characterized in that: described tablet is effervescent tablet or is dispersible tablet, with suitable coating material coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100522435A CN1899425B (en) | 2006-06-30 | 2006-06-30 | Chinese medicine composition for treating emmeniopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100522435A CN1899425B (en) | 2006-06-30 | 2006-06-30 | Chinese medicine composition for treating emmeniopathy |
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| Publication Number | Publication Date |
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| CN1899425A CN1899425A (en) | 2007-01-24 |
| CN1899425B true CN1899425B (en) | 2011-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006100522435A Expired - Fee Related CN1899425B (en) | 2006-06-30 | 2006-06-30 | Chinese medicine composition for treating emmeniopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103006876B (en) * | 2013-01-09 | 2013-10-30 | 张守红 | Externally used traditional Chinese medicine pills for treating metrorrhagia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135905A (en) * | 1995-05-18 | 1996-11-20 | 辽宁中医学院附属医院 | Medicine for regulating menstruation |
| CN1456245A (en) * | 2003-02-18 | 2003-11-19 | 毛友昌 | Preparation of tablets for profuse menstruation |
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- 2006-06-30 CN CN2006100522435A patent/CN1899425B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135905A (en) * | 1995-05-18 | 1996-11-20 | 辽宁中医学院附属医院 | Medicine for regulating menstruation |
| CN1456245A (en) * | 2003-02-18 | 2003-11-19 | 毛友昌 | Preparation of tablets for profuse menstruation |
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| CN1899425A (en) | 2007-01-24 |
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Effective date of registration: 20090109 Address after: Zhejiang city of Ningbo province Yinzhou District Yinxian Avenue East Zhejiang Pharmaceutical College No. 888 post encoding: 315100 Applicant after: Yang Xiong Zhi Co-applicant after: Yang Yijie Address before: 21, 4 floor, 293 South Rainbow Road, Jiangdong District, Zhejiang, Ningbo, China: 315040 Applicant before: Yang Yijie |
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Owner name: YANG XIONGZHI Free format text: FORMER OWNER: YANG YIKAI Effective date: 20090109 |
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Owner name: NINGBO YUANZHI BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: YANG XIONGZHI Effective date: 20110927 Free format text: FORMER OWNER: YANG YIKAI |
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Effective date of registration: 20110927 Address after: 315100, room 10, building 68, Lane 402, Tai Mo Road, Ningbo, Zhejiang, Yinzhou District Applicant after: Ningbo Yuanzhi Biotechnology Co., Ltd. Address before: 315100 Zhejiang city of Ningbo province Yinzhou District County Road No. 888 east section of Zhejiang Pharmaceutical College Applicant before: Yang Xiongzhi Co-applicant before: Yang Yijie |
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