CN1814193B - Chinese medicine composition for treating nephritis dropsy and preparation method thereof - Google Patents
Chinese medicine composition for treating nephritis dropsy and preparation method thereof Download PDFInfo
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- CN1814193B CN1814193B CN 200510061801 CN200510061801A CN1814193B CN 1814193 B CN1814193 B CN 1814193B CN 200510061801 CN200510061801 CN 200510061801 CN 200510061801 A CN200510061801 A CN 200510061801A CN 1814193 B CN1814193 B CN 1814193B
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Abstract
The invention discloses a Chinese medicinal combination for curing nephritis and edema and the application thereof, composed of Chinese Brake Herb, Jixuecao, Liquoricee Root, Persimmon Leaf, Membranous Milkvetch Root, Plantain Herb, etc. It is to be orally taken, convenient to use, tasting good and easy to be accepted by patients; has functions of nourishing liver and kidney, promoting blood circulation and rmoving blood stasis, and causing diuresis and detumescence, having advantages of good curative effect, short period of treatment, low price, no toxicity and side effect, convenient for patients to take, etc; and it is an ideal effective medicine for patients with acute and chronic nephritis and edema, hematuria, and albuminuria to select.
Description
Technical field
The present invention relates to field of medicaments, is a kind of Chinese medicine composition and application thereof for the treatment of oedema due to nephritis specifically
Background technology
Oedema due to nephritis is a kind of major disease that has a strong impact on human body health.Annual, oedema due to nephritis accounts for first of this disease because of causing the patient of renal failure.The nephritis kind is a lot, wherein acute nephritis edema is a kind of because the both sides kidney diffusivity glomerule infringement that allergy causes after infecting is main acute illness, the characteristics of primary disease are that morbidity is anxious, and serial clinical manifestations such as hematuria, albuminuria, cylinderuria, edema, oliguria, hypertension appear in 1～3 week after infection.Cause that by bacterial infection 30%～80% acute nephritis mostly occurred in summer.Child, the easiest trouble acute nephritis of teenager generally can account for more than 80% of acute nephritis sickness rate.North winter-spring season is pharyngitis, upper respiratory tract infection, tonsillitic multiple season, and the acute nephritis more than 90% all occurs in this two seasons.Acute nephritis male for seeing more, and men and women's ratio is about 2: 1.Chronic glomerulonephritis abbreviates chronic nephritis as, is that a kind of (even many decades) of growing the course of disease that various primary glomerulopathies cause is the disease of clinical manifestation with albuminuria, hematuria, edema, hypertension.This disease is common, especially with the young sickness rate height of male adults.
Acute and chronic glomerulonephritis (being called for short acute and chronic nephritis) is because after infecting (especially hemolytic streptococcal infection), cause immunoreation, antigen antibody complex deposits in glomerule, and acute diffusivity and immune inflammation pathological changes take place the glomerule that causes the both sides kidney.Mainly show for it with edema, albuminuria, hematuria, hypertension and all renal function injury.This is commonly encountered diseases, frequently-occurring disease in the population of China, its sickness rate height, and the patient is wide, is the health problem that we can not be ignored.Therefore seek effective medicine, be the target that domestic nephropathy circle is made joint efforts always.In the Western medicine of various treatment nephritis now, the Chinese medicine, the drug side effect that has is big; The curative effect that has is not remarkable; Have owing to reasons such as dosage forms, the curative effect instability has limited its range of application; So overall therapeutic effect is not really desirable.
Summary of the invention
The purpose of this invention is to provide a kind of pure Chinese medicinal preparation for the treatment of acute and chronic oedema due to nephritis.It follows the principle of the traditional Chinese medical science " sthenia syndrome requiring purgation " and " deficiency syndrome should be treated by tonifying method ", effect with liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, aim to provide and a kind ofly can either play fine treatment or relief of symptoms effect nephritis, have advantages such as good effect, the cycle is short, price is low, have no side effect, a kind of Chinese medicine composition that the patient is taken like a shot.It all has good effect to acute and chronic oedema due to nephritis, hematuria, albuminuria.
The present invention develops Chinese medicine composition meticulously according to traditional Chinese medical science prescription and preparation principle, realizes by following technical scheme:
The consumption of drug component of the present invention is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges, and medicine of the present invention contains
166～498 parts of 166～498 parts of Radixs Astragali of 331～999 parts of Herba Centellaes of Herba Pteridis Multifidae
166～498 parts of 166～498 parts of Folium Kaki of 166～498 parts of Ramulus et Folium Mussaendae Pubescentis of Herba Plantaginis
Preferable range is:
248～496 parts of 248～496 parts of Radixs Astragali of 498～998 parts of Herba Centellaes of Herba Pteridis Multifidae
248～496 parts of 248～496 parts of Folium Kaki of 248～496 parts of Ramulus et Folium Mussaendae Pubescentis of Herba Plantaginis
Optimum weight part is:
331 parts of 331 parts of Radixs Astragali of 662 parts of Herba Centellaes of Herba Pteridis Multifidae
331 parts of 222 parts of Folium Kaki of 331 parts of Ramulus et Folium Mussaendae Pubescentis of Herba Plantaginis
Technical problem to be solved by this invention is to realize by following technical scheme.Be characterized in that with Herba Pteridis Multifidae, Herba Centellae, the Radix Astragali, Herba Plantaginis, Ramulus et Folium Mussaendae Pubescentis, Folium Kaki etc. be the medicine that raw material is made.The Chinese medicine composition of this treatment nephritis is characterized in that it is that component is formed or made active component and pharmaceutically acceptable additives are formed or make active component and pharmaceutically acceptable additives are formed by the alcohol extract of following main materials by the water extract of following main materials by following main materials.The present invention is by scientific combination, development meticulously, effect with liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, have advantages such as good effect, the cycle is short, price is low, have no side effect, it all has good effect to acute and chronic nephritis edema, hematuria, albuminuria.
Medicine of the present invention can adopt the Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably crude drug Herba Pteridis Multifidae, Herba Centellae, Ramulus et Folium Mussaendae Pubescentis are carried out ethanol extraction, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine better bring into play drug effect.
Described pharmaceutically acceptable additives are following one or more: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, ethanol, dried starch, citric acid, sodium bicarbonate, ethyl hydroxybenzoate, tartaric acid, lecithin, sodium lauryl sulphate.
Its dosage form can be a said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule can be common capsule, effervescent capsule or other various suitable capsules; Described tablet can be common tablet, effervescent tablet, dispersible tablet or other various suitable tablets, can be with suitable coating material coating also coating not; The preferred particulates agent.
The specific embodiment
Describe implementation of the present invention in detail below in conjunction with embodiment.
Embodiment 1:
The preparation method of granule of the present invention: medicine of the present invention can prepare by the following method:
(a) take by weighing former medicines such as Herba Pteridis Multifidae 500 grams, Herba Centellae 500 grams, Ramulus et Folium Mussaendae Pubescentis 250 grams, Folium Kaki 350 grams, the Radix Astragali 500 grams, Herba Plantaginis 250 grams and that coarser powder is ground in its pulverizing is standby by weight ratio;
(b) Herba Pteridis Multifidae, Herba Centellae, the Ramulus et Folium Mussaendae Pubescentis with described weight proportion carries out reflux, extract, twice with 70%～95% ethanol, merges extracted twice liquid, reclaims ethanol, is condensed into proportion and is 1.15～1.35 extractum, 45～55 ℃ dry down, dry extract 1;
(c) residue after Folium Kaki, the Radix Astragali, Herba Plantaginis and the Herba Pteridis Multifidae of described weight proportion, Herba Centellae, the Ramulus et Folium Mussaendae Pubescentis alcohol extraction is decocted with water twice, add water was not advisable to have powder at every turn, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, the active component of preparation cost invention medicine;
(e) with gained active component and pharmaceutically acceptable additives such as correctives, the abundant mixing of adjuvant, make any dosage form of pharmaceutics.As above-mentioned active component was pulverized 100 mesh sieves, with pharmaceutically acceptable additives such as mixings such as ethanol, starch, moistening, soften, take out when forming agglomerate, make dissolved granule.
In the above-mentioned preparation method, when in the preferred steps (b) medicine being added ethanol extraction, adding amount of alcohol for the first time is 12 times, extracts 1 hour, and add amount of alcohol the second time is 10 times, extracts 1 hour.(c) during with the medicine extracting in water, add 10 times in water for the first time in, decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours.
Embodiment 2:
The preparation method of syrup of the present invention:, each 1 hour, filter with Herba Pteridis Multifidae 500 grams, Herba Centellae 500 grams, Ramulus et Folium Mussaendae Pubescentis 250 grams, Folium Kaki 350 grams, the Radix Astragali 500 grams, Herba Plantaginis 250 gram decocting secondaries, merging filtrate, be condensed into thick paste, add the ethanol precipitation secondary, make to contain pure flow control and once reach 65%, for the second time reach 80%, filter, reclaim ethanol and be concentrated into about 700mL, stir molten with sucrose, ethyl hydroxybenzoate alcohol liquid while hot, add boiling water again to full dose, stir evenly promptly to get and make syrup.
Embodiment 3:
The preparation method of tablet of the present invention:
The broken coarser powder that grind into of former medicated powder such as Herba Pteridis Multifidae 555 grams, Herba Centellae 555 grams, the Radix Astragali 455 grams, Herba Plantaginis 350 grams, Ramulus et Folium Mussaendae Pubescentis 250 grams, Folium Kaki 250 grams is standby; After making granule by example 1 method, add an amount of additives, mixing, tabletting, coating are made suitable tablet.The decocting secondary, 2 hours for the first time, 1 hour for the second time, filter, filtrate is condensed into thick paste, drying was pulverized 100 mesh sieves, mixing, moistening, soften, take out when forming agglomerate, make dissolved granule.
In like manner, press the method for embodiment 1, add suitable capsule etc.
Preparation of the present invention is fragrant faint yellow granule, sepia syrup or tablet or capsule.
More than during each forms, weight is calculated with crude drug, in the present invention, if weight is unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, described 1000 doses of fingers, 1000 doses in the final drug preparation of making, as make 1000 in 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000 peace bottles, injection 1000 peace bottles, drop pill etc., also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 150 bags, 200 bags, 250 bags, 500 bags, every bag can be used as dose 1 time.This weight of formulation can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
For a better understanding of the present invention, below further set forth the action effect of medicine of the present invention in pharmacology and clinical research, but not to the restriction of effect of the present invention.
(1) diagnosis basis:
According to clinical glomerulonephritis case diagnosis standard, observe 28 routine patients, be divided into 2 groups, every group 14 example.Matched group adopts the treatment of control drug SHENYAN SIWEI PIAN, and the treatment group adopts the treatment of this medicine.The main inspection item of laboratory:
1, Niao change
1. hematuria; 2. urine protein＞++; Uropsammus examination: can see the pleomorphism erythrocyte, leukocyte, epithelial cell, hyaline cast and the inside grain cast;
2, blood routine examination
1. hemoglobin and RBC number reduce; 2. adstante febre, total white blood cells and neutrophilic granulocyte often increase;
3, kidney function test
Creatinine in the serum, the modern content of blood urea nitrogen increases.
4, the visible hypertension of part patient.
(2) medicinal granule experimental result of the present invention:
1, nephritis patient use urine protein before and after this medicine treatment＞++ the variation of routine number %
The present invention has the effect of quick reduction urine protein to the glomerulonephritis patient, treats after 7 days, and urine protein＞++ routine number is 30%, treats after 14 days, and urine protein＞++ routine number is 13%, the results are shown in Table 1;
Table 1 nephritis patient use urine protein before and after this medicine treatment＞++ the variation of routine number %
Annotate: matched group, treatment group compare respectively with before and after each group treatment, adopt the t check,
*P＜0.05
*P＜0.01
2, nephritis patient uses the variation of this medicine treatment front and back serum creatinines (μ mol/L)
The present invention has the effect of quick reduction serum creatinine to the glomerulonephritis patient, treats before the back 14 days treatment groups in back 7 days, treatment and the treatment relatively, and there is the significance difference p＜0.05, with matched group relatively＜0.05, the significance difference is arranged, and the results are shown in Table 2;
Table 2 nephritis patient use serum creatinines (μ mol/L) before and after this medicine treatment variation (n=12,
Annotate: matched group, treatment group compare respectively with before and after each group treatment, adopt the t check,
*P＜0.05
3. nephritis patient uses the variation of the preceding blood urea nitrogen (mol/L) of this medicine treatment
The present invention can reduce the effect of blood urea nitrogen fast to the glomerulonephritis patient, treats back 7 days, treatment back 14 days, and relatively, there is the significance difference P＜0.05 before treatment group and the treatment, with matched group p＜0.05 relatively, the significance difference is arranged, and the results are shown in Table 3;
The variation of blood urea nitrogen (mol/L) before table 3 nephritis patient uses this medicine to treat (n=12,
Annotate: matched group, treatment group compare respectively with before and after each group treatment, adopt the t check,
*P＜0.05.
4, matched group, treatment group clinical effectiveness relatively see Table 4;
Table 4 clinical effectiveness is as follows:
According to above clinical pharmacology result of study, the present invention has the effect of liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema really, can either play fine treatment or relief of symptoms effect to nephritis, have advantages such as good effect, the cycle is short, price is low, have no side effect, can make patient's taking convenience again, take like a shot; To acute and chronic oedema due to nephritis, hematuria, albuminuria patient is a kind of medicine of effective selection.
Claims (9)
1. Chinese medicine composition for the treatment of oedema due to nephritis, it is characterized in that: the weight portion of each crude drug is:
166～498 parts of 166～498 parts of Radixs Astragali of 331～999 parts of Herba Centellaes of Herba Pteridis Multifidae
166～498 parts of 166～498 parts of Folium Kaki of 166～498 parts of Ramulus et Folium Mussaendae Pubescentis of Herba Plantaginis;
(a) take by weighing Herba Pteridis Multifidae, Herba Centellae, Ramulus et Folium Mussaendae Pubescentis, Folium Kaki, the Radix Astragali, Herba Plantaginis and pulverize that to grind into coarser powder standby by weight;
(b) Herba Pteridis Multifidae, Herba Centellae, the Ramulus et Folium Mussaendae Pubescentis with described weight portion carries out reflux, extract, twice with 70%～95% ethanol, merges extracted twice liquid, reclaims ethanol, is condensed into proportion and is 1.15～1.35 extractum, 45～55 ℃ dry down, dry extract 1;
(c) residue after Folium Kaki, the Radix Astragali, Herba Plantaginis and the Herba Pteridis Multifidae of described weight portion, Herba Centellae, the Ramulus et Folium Mussaendae Pubescentis alcohol extraction is decocted with water twice, add water at every turn and do not have powder, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, be prepared into the active component of medicine;
(e) with gained active component and the abundant mixing of receptible additives pharmaceutically, make any dosage form of pharmaceutics.
2. a kind of Chinese medicine composition for the treatment of oedema due to nephritis according to claim 1, it is characterized in that: the weight portion of described each crude drug is:
331 parts of 331 parts of Radixs Astragali of 662 parts of Herba Centellaes of Herba Pteridis Multifidae
331 parts of 222 parts of Folium Kaki of 331 parts of Ramulus et Folium Mussaendae Pubescentis of Herba Plantaginis.
3. a kind of Chinese medicine composition for the treatment of oedema due to nephritis according to claim 1 is characterized in that: described pharmaceutically receptible additives are following more than one: glycerol, gelatin, Polyethylene Glycol, propylene glycol, dextrin, dried starch, ethylparaben, tartaric acid, citric acid, sodium bicarbonate, lecithin, sodium lauryl sulphate.
4. a kind of Chinese medicine composition for the treatment of oedema due to nephritis according to claim 1 is characterized in that: its dosage form is effervescent granule electuary, capsule or tablet.
5. a kind of Chinese medicine composition for the treatment of oedema due to nephritis according to claim 4 is characterized in that: described capsule is the effervescent capsule.
6. a kind of Chinese medicine composition for the treatment of oedema due to nephritis according to claim 4 is characterized in that: described tablet is effervescent tablet or is dispersible tablet, with suitable coating material coating.
7. one kind prepares the described a kind of method for the treatment of the Chinese medicine composition of oedema due to nephritis of claim 1, it is characterized in that comprising the steps:
(a) take by weighing Herba Pteridis Multifidae, Herba Centellae, Ramulus et Folium Mussaendae Pubescentis, Folium Kaki, the Radix Astragali, Herba Plantaginis and pulverize that to grind into coarser powder standby by weight;
(b) Herba Pteridis Multifidae, Herba Centellae, the Ramulus et Folium Mussaendae Pubescentis with described weight portion carries out reflux, extract, twice with 70%～95% ethanol, merges extracted twice liquid, reclaims ethanol, is condensed into proportion and is 1.15～1.35 extractum, 45～55 ℃ dry down, dry extract 1;
(c) residue after Folium Kaki, the Radix Astragali, Herba Plantaginis and the Herba Pteridis Multifidae of described weight portion, Herba Centellae, the Ramulus et Folium Mussaendae Pubescentis alcohol extraction is decocted with water twice, add water at every turn and do not have powder, merge decocting liquid twice, filter to get filtrate 2, it is 1.15～1.35 extractum that concentrated filtrate becomes proportion, dry under 45～55 ℃, get dry extract 2;
(d) merge dry extract 1 and 2, it is ground into powder, be prepared into the active component of medicine;
(e) with gained active component and the abundant mixing of receptible additives pharmaceutically, make any dosage form of pharmaceutics.
8. method according to claim 7 is characterized in that: when adding ethanol extraction in the described step (b), adding amount of alcohol for the first time is 12 times, extracts 1 hour, and adding amount of alcohol for the second time is 10 times, extracts 1 hour; Spissated extractum proportion is 1.15.
9. method according to claim 7 is characterized in that: during extracting in water, add 10 times in water for the first time in the described step (c), decocted 2 hours, add 8 times in water the second time, decocted 1.5 hours; Spissated extractum proportion is 1.20.
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| CN 200510061801 CN1814193B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating nephritis dropsy and preparation method thereof |
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| CN 200510061801 CN1814193B (en) | 2005-12-05 | 2005-12-05 | Chinese medicine composition for treating nephritis dropsy and preparation method thereof |
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| CN1814193B true CN1814193B (en) | 2011-02-16 |
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| CN104225192A (en) * | 2014-09-02 | 2014-12-24 | 苏州卫生职业技术学院 | Traditional Chinese medicine composition for treating leg edema and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089592C (en) * | 1995-05-30 | 2002-08-28 | 吴常庆 | Chinese medicine for treating acute and chronic nephritis |
| CN1528376A (en) * | 2003-09-30 | 2004-09-15 | 牛联改 | Chinese medicine for treating chronic nephritis and chronic renal insufficiency |
| CN1651049A (en) * | 2001-11-18 | 2005-08-10 | 孙燕明 | Chinese medicinal preparation for treating pelvis nephritis |
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2005
- 2005-12-05 CN CN 200510061801 patent/CN1814193B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089592C (en) * | 1995-05-30 | 2002-08-28 | 吴常庆 | Chinese medicine for treating acute and chronic nephritis |
| CN1651049A (en) * | 2001-11-18 | 2005-08-10 | 孙燕明 | Chinese medicinal preparation for treating pelvis nephritis |
| CN1528376A (en) * | 2003-09-30 | 2004-09-15 | 牛联改 | Chinese medicine for treating chronic nephritis and chronic renal insufficiency |
Non-Patent Citations (4)
| Title |
|---|
| 吴金国等.急慢性肾炎中药治疗研究进展.中医药信息18 4.2001,18(4),5-7. |
| 吴金国等.急慢性肾炎中药治疗研究进展.中医药信息18 4.2001,18(4),5-7. * |
| 文明清等.知柏地黄汤加味治疗慢性肾盂肾炎52例.湖南中医杂志20 2.2004,20(2),39-40. |
| 文明清等.知柏地黄汤加味治疗慢性肾盂肾炎52例.湖南中医杂志20 2.2004,20(2),39-40. * |
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