CN101371882A - Method for preparing Artemisia capillaris decoction formulation - Google Patents
Method for preparing Artemisia capillaris decoction formulation Download PDFInfo
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- CN101371882A CN101371882A CNA2007101461503A CN200710146150A CN101371882A CN 101371882 A CN101371882 A CN 101371882A CN A2007101461503 A CNA2007101461503 A CN A2007101461503A CN 200710146150 A CN200710146150 A CN 200710146150A CN 101371882 A CN101371882 A CN 101371882A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, in particular to a preparation method of a virgate wormwood decoction preparation. In order to return to the essence of the traditional medicine for the treatment of diseases, the invention proposes the guideline that the classic formula of the virgate wormwood decoction is in line with the ancient way, medicine is extracted by using water, and the preparation method is further combined with the modern concentration and granulation processes, thereby summing up the preparation process parameters and the applicable excipients which are most matched with the virgate wormwood decoction. The accumulated experiences of the traditional medicine are retained to the maximum extent, and the preparation method can also meet the needs of preparation forms which are applicable to the rapid pace of modern society, such as granules, tablets, capsules, powder, dropping pills, and the like.
Description
[technical field]
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Herba Artemisiae Scopariae Decoction preparation and preparation method thereof.
[background technology]
Herba Artemisiae Scopariae is the dry seedling of feverfew BINHAO Artemisia scoparia Waldst et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..
Herba Artemisiae Scopariae is a perennial herb, high 30～100cm, and seedling is close by the fine and soft hair of white, comes off when old; Stem is upright, multi-branched.Basal leaf has handle, and 2～3 split that pinniform is totally cleaved or palmation, and final sliver is linear; The leaf stockless of spray, pinniform is totally cleaved into thread.Head inflorescence is coniform, inflorescence diameter 1.5～2mm; The involucre sphere, 3～4 layers of phyllarys; The flower polygamy, on each holder with each about 5 of hermaphrodite flower and female flowers, be the lavender tubular flower, instaminate flower is long slightly than hermaphrodite flower, only there is a gynoecium in central authorities, stretch out outside the corolla, stigma 2 splits and is forked; The hermaphrodite flower synandrium, gynoecium 1 does not stretch out, and the stigma head does not divide.The achene Long Circle does not have hair.9～October of florescence, fruit phase 11～December.
The Herba Artemisiae Scopariae function cures mainly and is clearing away damp-heat, the jaundice eliminating subcutaneous ulcer.Be used for the jaundice oliguria, the eczema pruritus; Infectious jaundice type hepatitis etc.
Herba Artemisiae Scopariae contains the effective ingredient escoparone of tool choleretic effect, and promptly 6, it is different because of season that 7-dimethoxy coumarin contains rate, and florescence is the highest, reaches 1.98%, and chlorogenic acid and caffeic acid.Herb contains quintessence oil about 0.27%; Quintessence oil is more in the fruit ear, contains rate and reaches 1%.Its composition has: nopinene, capillin, capillon, capillene, capillarin.Also fatty oil, wherein fatty acid is a stearic acid, Palmic acid, oleic acid, linoleic acid, arachidic acid, montanic acid.Contain potassium chloride in the ash.Also contain escoparone and potassium chloride in the seed.
The source of Radix Et Rhizoma Rhei is the root and rhizome of Polygonaceae sorrel Rheum palmatum L. or Rheum tanguticum Rheumtanguticum Maxim.ex Balf. and Rheum officinale Rheum officinale Baill..The sorrel main product in Gansu, ground such as Qinghai, Tibet, Sichuan, be mainly cultivation, output accounts for the major part of Radix Et Rhizoma Rhei; The Rheum tanguticum main product in Qinghai, Gansu, Tibet and area, Sichuan, wild or cultivation.The Rheum officinale main product in Sichuan, provinces such as Guizhou, Yunnan, Hubei, Shaanxi, cultivation or wild, output is less.Radix Et Rhizoma Rhei gas delicate fragrance, bitter in the mouth is little puckery, and that chews sticks to one's teeth, and grains of sand sense is arranged, and saliva is dyed yellow; Rhizome cross section: the fascicular anomalous structure of tool marrow.
The effective ingredient of Radix Et Rhizoma Rhei mainly contains: the dissociated anthraquinone derivant: aloe-emodin (aloeemodin), chrysophanic acid (rhein), emodin (emodin), chrysophanol (chrysophanol), physcione (physcion) etc.; The associativity anthraquinone derivative: the glucoside of dissociated anthraquinone class or dianthracene ketoside are the following composition of mainly rushing down of Radix Et Rhizoma Rhei.The dianthracene ketoside is Sennoside A, B, C, D, E, F (sennosid A, B, C, D, E, F) etc., and discharge function is strong.Rheochrysin (rheinoside A, B, C, D) is also for rushing down composition down.Tannin class material about 5%: galloyl glucose, gallic acid, d-catechin etc. are astringent component.
Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae (Gardenia jasminoides Ellis.), has another name called SHANZHIZI, Yellow Fructus Gardeniae etc.The Fructus Gardeniae bitter in the mouth, cold in nature, GUIXIN, liver, lung, stomach warp have the effect of pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.Fructus Gardeniae is mainly used in:
1. calentura dysphoria with smothery sensation.This product bitter cold is fallen clearly, rushes down the three warmers pathogenic fire clearly, and the effect of the relieving restlessness of clearing away heart-fire is arranged.
2. jaundice due to damp-heat.Because of it can removing damp-heat from the liver and the gallbladder jaundice eliminating subcutaneous ulcer.
3. heat in blood is told nosebleed.
4. sore swollen toxin, traumatic injury." herbal classic " carries, Fructus Gardeniae " pathogen in main five, pathogenic heat in the stomach gas, flushed complexion wine skin ulcer abdomen nose, the red impetigo infections of tuberculoid leprosy "." Amplification on Materia Medica addendum " said: " rush down the three warmers fire, clearing stomach gastral cavity blood is controlled epigastric pain with cold limbs due to adverseness of heat, separates heat stagnation, the row stagnation of QI.”
Modern study confirms that Fructus Gardeniae contains gardenin, gardenoside, geniposide and crocin, crocetin, ursolic acid etc.Fructus Gardeniae decoct and alcohol extract have choleretic effect, can promote bile secretion, and can reduce blood mesobilirubin, can promote blood mesobilirubin to drain rapidly; Hemolytic streptococcus and dermatophytes there is inhibitory action; Analgesic, analgesia, calm, blood pressure lowering and anastalsis are arranged.
The prescription of Herba Artemisiae Scopariae Decoction is derived from treatise on Febrile Diseases: " this is that heat is got over, and can not turn to be yellow also for YANG MING syndrome, fever and sweating person; " " typhoid fever seven or eight days, color of the skin being yellow as peel of orange, dysuria, the slight fullness in the abdomen person, the Herba Artemisiae Scopariae Decoction master it.Herba Artemisiae Scopariae Decoction is made up of Herba Artemisiae Scopariae, Fructus Gardeniae and Radix Et Rhizoma Rhei three flavor medicines.
Herba Artemisiae Scopariae Decoction cures mainly jaundice due to damp-heat, and appearance is all yellow all over the body, and color is distinct in Fructus Citri tangerinae, and slight fullness in the abdomen is thirsty in mouthful, dysuria, yellowish fur, deep and forceful pulse or sliding number.Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis in the side, dredging sharp liver and gall is monarch; It is damp and hot that Fructus Gardeniae lets out three warmers clearly, but and jaundice eliminating be minister; Radix Et Rhizoma Rhei tonneau stool, behavior assistant under the heat conduction, three medicines match, and damp and hot heresy is just drained from two, and wet reducing phlegm and internal heat removed, and then jaundice is from moving back.
In recent decades, the production of Chinese herbal medicine has realized mechanization and semi-mechanization to a certain degree.Chinese medicine often is considered to that active constituent content is low, impurity is many, quality is unstable, so medication is based upon on the empirical basis more, can not integrate with modern medicine.For addressing this problem, Chinese medicine must be walked the road of extraction and purification.The extraction of Chinese medicine comprises many unit operationss such as leaching, clarification, filtration and evaporation.
[summary of the invention]
The preparation method that the purpose of this invention is to provide a kind of new Herba Artemisiae Scopariae Decoction preparation.Basis of the present invention prescription derives from Herba Artemisiae Scopariae Decoction.
Herba Artemisiae Scopariae Decoction preparation of the present invention, its prescription consists of Fructus Gardeniae 200-400 part, Herba Artemisiae Scopariae 300-600 part, Radix Et Rhizoma Rhei 50-150 part, its preparation method is: Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and Fructus Gardeniae are decocted with water 1-4 time each 0.5-3 hour, merge decocting liquid, filter the back concentrate fluid extract, add behind the adjuvant with behind the fluidized bed granulation useful in preparing drug formulations.
The proportion of above-mentioned fluid extract is 1.10-1.35, preferred 1.15-1.30.
Above-mentioned decocting liquid can carry out centrifugation earlier, gets clarifying decocting liquid, and centrifugal rotation speed is 1500-20000 rev/min, and preferred 1500-10000 rev/min, more preferably 2000-8000 rev/min, most preferably 3000-5000 rev/min.
Above-mentioned decocting liquid can adopt the method for membrane filtration to filter.
Above-mentioned membrane filtration comprises one of filter method of employing ultrafiltration and nanofiltration or ultrafiltration and nanofiltration is used in combination.
Above-mentioned ultrafilter membrane is selected from cellulose diacetate film, three cellulose acetate membrane, cyanoethyl cellulose film, polysulfone membrane, sulfonated polysulfone membrane, poly (ether sulfone) film, sulfonated polyether sulfone film, polysulfonamides film, phenolphthalein side group polyarylsulfone (PAS) film, polyvinylidene fluoride film, polyacrylonitrile film, polyimide film, cellulose membrane, methyl methacrylate-acrylonitrile copolymer film, polyacrylonitrile-cellulose diacetate blend film, the dynamic ultrafilter membrane that forms, one of and the Modified Membrane of above-mentioned film, its molecular retention amount is below the 6000-10000.
The filter membrane aperture of above-mentioned ultrafiltration is: the 0.22-0.45 micron.
The membrane ultrafiltration device that above-mentioned ultrafiltration is adopted can be commercial doughnut or plate ultrafilter membrane separator.
Above-mentioned NF membrane molecular retention amount is 500-2000, preferred 500-1000, more preferably 700-1000.
The process of above-mentioned membrane filtration preferably with the process ultrafiltration earlier of decocting liquid, is carried out nanofiltration again.
Above-mentioned adjuvant is selected from microcrystalline Cellulose, powdery cellulose, mannitol, starch, lactose, gelatin, methylcellulose, dextrin, pregelatinized Starch, micropowder silica gel, hydroxypropyl methylcellulose, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, Polyethylene Glycol, xylitol, lactose, glucose, glycine, mannitol, tartaric acid, silicon dioxide, one or more in calcium stearate and the magnesium stearate.
The said medicine preparation comprises granule, tablet, capsule, powder, drop pill.
In the above-mentioned fluidized bed granulation process, the optimization technique parameter of fluid bed fluidized granulating is: atomisation pressure 0.15-0.40 MPa; Temperature of charge 50-65 ℃; Inlet temperature 68-100 ℃; Leaving air temp 35-65 ℃; Preferably, atomisation pressure 0.15-0.40 MPa; Temperature of charge 55-60 ℃; Inlet temperature 80-100 ℃; Leaving air temp 60-65 ℃.
The technical study of fluid bed boiling patent of the present invention comprises:
1. dosage form selection: according to the clinical application needs, square taste of Chinese medicine character and active ingredient physicochemical property thereof and a day clothes crude drug amount in conjunction with factors such as the market demands, are selected dosage form.The present invention should be developed into dosage forms such as granule, capsule, tablet, drop pill, soft capsule, powder, syrup preparation or dispersible tablet, and they can satisfy the clinical day big needs of clothes dosage, and preserve, transport, carry and taking convenience.
But when granulating, find the water extraction after-filtration, put boiling granulating in the fluid bed again.The process route of drafting had both shortened production technology, had reduced supplementary product consumption again, was beneficial to molding.
2. isolation and purification technical study: the former prescription of this product day clothes crude drug amount is big, therefore should discard the dross and select the essential as far as possible, and it is more that water is carried the part impurities, as macromolecular substances and solid particles such as protein, phlegmatic temperaments.Also can adopt centrifugal (2000-20000 rev/min) method, reach impurity-eliminating effect.
3. concentration technology research: method for concentration is selected, and controls and avoid loss of effective components, water to carry medicinal liquid for the ease of production operation to concentrate, and getting relative density is the clear paste of 1.10-1.35.
4. granulating process research: (1) method of granulating is investigated: method of granulating once adopted wet granulation, selected for use Different concentrations of alcohol and PVP to granulate, and easily bonding is softening because of extractum, and operating difficulties is so abandon this kind method.Boiling method in the fluid bed is adopted in the back, for mix homogeneously, after the merging of water extract, adds an amount of adjuvant, mixing, and boiling granulating in fluid bed, promptly.
The investigation of fluidized granulating important technological parameters is screened the fluidized granulating important technological parameters, and concrete outcome sees Table 1.
Table 1 fluidized granulating important technological parameters is investigated
The important technological parameters of fluid bed fluidized granulating is as seen from the above table: atomisation pressure 0.15-0.40 MPa; Temperature of charge 50-65 ℃; Inlet temperature 68-100 ℃; Leaving air temp 35-65 ℃.
The at present used extracting technique of Chinese medicine compound recipes that adopt certain density ethanol extraction Chinese medicine more, help reclaiming solvent like this and reduce impurity, but the method that adopts alcohol extraction has deviated from the experience accumulation of the treatment disease of Chinese medicine since 3000, has ignored for the purpose that can arrive " quality controllable " comparatively simply under the guiding theory of " modernization of Chinese medicine " " effectiveness " even " safety ".
In sum, the hysteresis of Chinese medicine extraction separating technology development becomes the bottleneck of traditional Chinese medicine development and existence, must be optimized, reform and strengthen original technology.The reinforcement technique of chemical separating and mass transfer will provide strong assurance for this reason, and realization Chinese medicine subject intersects with Chemical Engineering, will help realizing the modernization of Chinese medicine production equipment.With the Chinese medicine extraction separation process that induces one of notion, the theory of Chemical Engineering.Utilize available research achievements,,, technological process, production equipment, operating condition are done modernization overlay and careful groping, provided feasible scheme from basic influence factor's research staff in conjunction with the concrete condition that Chinese medicine is produced.
In order to return the marrow of traditional medicine treatment disease, the present invention proposes the guiding theory according to " abiding by Gu " with Herba Artemisiae Scopariae Decoction classics side, use the water extraction medicine, concentrated, granulating process in conjunction with modern have summed up the preparation process parameter and the suitable adjuvant that mate the most with the Herba Artemisiae Scopariae Decoction preparation.Kept the experience accumulation of traditional medicine to greatest extent, and it is allegro as dosage forms such as tablet, capsule, granule, powder, drop pills to adapt to modern society, for the innovation of traditional medicine provides a kind of new method and thinking.
[specific embodiment]
Following embodiment further describes the present invention, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Embodiment 1
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2 hours, amount of water is 10 times of medical material, merges the water extract, filters, decompression and solvent recovery, get fluid extract (proportion is 1.18-1.25), add adjuvant boiling granulating in fluid bed, promptly get granular preparation of the present invention.
Embodiment 2
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 4 times with water extraction, each 1 hour, amount of water was 10 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.25-1.34), adds adjuvant boiling granulating in fluid bed, encapsulated, promptly obtain capsule preparations of the present invention.
Embodiment 3
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water was 6 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.28-1.35), adds adjuvant boiling granulating in fluid bed, add the adjuvant tabletting, promptly obtain tablet of the present invention.
Embodiment 4
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 3 hours, amount of water was 8 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.26-1.30), add adjuvant boiling granulating in fluid bed, add vegetable oil substrate, pill promptly obtains drop pill of the present invention.
Embodiment 5
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2.5 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.21-1.32), add adjuvant boiling granulating in fluid bed, add 200 gram vegetable oil, mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 6
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 1.5 hours, amount of water was 6 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.28-1.34), adds adjuvant boiling granulating in fluid bed, pulverize, promptly obtain powder of the present invention.
Embodiment 7
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water was 8 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.28-1.35), add adjuvant boiling granulating in fluid bed, add sodium carboxymethyl cellulose, tabletting promptly obtains dispersible tablet of the present invention.
Embodiment 8
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2 hours, amount of water is 12 times of medical material, merges the water extract, filters, decompression and solvent recovery, get fluid extract (proportion is 1.13-1.18), add adjuvant boiling granulating in fluid bed, promptly get granular preparation of the present invention.
Embodiment 9
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water was 8 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.15-1.21), adds adjuvant boiling granulating in fluid bed, encapsulated, promptly obtain capsule preparations of the present invention.
Embodiment 10
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water was 10 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.10-1.19), adds adjuvant boiling granulating in fluid bed, add the adjuvant tabletting, promptly obtain tablet of the present invention.
Embodiment 11
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 3 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.20-1.26), add adjuvant boiling granulating in fluid bed, add vegetable oil substrate, pill promptly obtains drop pill of the present invention.
Embodiment 12
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2.5 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.19-1.25), add adjuvant boiling granulating in fluid bed, add 200 gram vegetable oil, mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 13
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 1.5 hours, amount of water was 10 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.20-1.24), adds adjuvant boiling granulating in fluid bed, pulverize, promptly obtain powder of the present invention.
Embodiment 14
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water was 6 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.18-1.23), add adjuvant boiling granulating in fluid bed, add sodium carboxymethyl cellulose, tabletting promptly obtains dispersible tablet of the present invention.
Embodiment 15
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times each 2 hours with water extraction, amount of water is 6 times of medical material, merges the water extract, filters, filtrate is 8000 three cellulose acetate membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.85 times of former ultrafiltrate, get fluid extract (proportion is 1.18-1.25), add adjuvant boiling granulating in fluid bed, promptly get granular preparation of the present invention.
Embodiment 16
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times each 2 hours with water extraction, amount of water is 8 times of medical material, merges the water extract, filters, filtrate is 6000 cyanoethyl cellulose membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.8 times of former ultrafiltrate, get fluid extract (proportion is 1.25-1.34), add adjuvant boiling granulating in fluid bed, encapsulated, promptly obtain capsule preparations of the present invention.
Embodiment 17
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times with water extraction, and each 2 hours, amount of water was 6 times of medical material, merged the water extract, filter, and filtrate is 10000 polysulfone membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.75 times of former ultrafiltrate, get fluid extract (proportion is 1.28-1.35), add adjuvant boiling granulating in fluid bed, add the adjuvant tabletting, promptly obtain tablet of the present invention.
Embodiment 18
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times with water extraction, and each 3 hours, amount of water was 10 times of medical material, merged the water extract, filter, and filtrate is 6000 SPSF membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 1000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.7 times of former ultrafiltrate, get fluid extract (proportion is 1.26-1.30), add adjuvant boiling granulating in fluid bed, add vegetable oil substrate, pill promptly obtains drop pill of the present invention.
Embodiment 19
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times with water extraction, and each 2.5 hours, amount of water was 10 times of medical material, merged the water extract, filter, and filtrate is 8000 poly (ether sulfone) film ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 2000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.75 times of former ultrafiltrate, get fluid extract (proportion is 1.21-1.32), add adjuvant boiling granulating in fluid bed, add 200 gram vegetable oil, mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 20
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times each 1.5 hours with water extraction, amount of water is 10 times of medical material, merges the water extract, filters, filtrate is 6000 sulfonated polyether sulfone membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.65 times of former ultrafiltrate, get fluid extract (proportion is 1.28-1.34), add adjuvant boiling granulating in fluid bed, pulverize, promptly obtain powder of the present invention.
Embodiment 21
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times with water extraction, and each 2 hours, amount of water was 12 times of medical material, merged the water extract, filter, and filtrate is 6000 polysulfonamides membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 1000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.75 times of former ultrafiltrate, get fluid extract (proportion is 1.28-1.35), add adjuvant boiling granulating in fluid bed, add sodium carboxymethyl cellulose, tabletting promptly obtains dispersible tablet of the present invention.
Embodiment 22
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 2000 rev/mins) filters, filtrate is 6000 three cellulose acetate membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.15-1.25), adds adjuvant boiling granulating in fluid bed, promptly gets granular preparation of the present invention.
Embodiment 23
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 2500 rev/mins) filters, filtrate is 8000 cyanoethyl cellulose membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.17-1.24), adds adjuvant boiling granulating in fluid bed, and is encapsulated, promptly obtains capsule preparations of the present invention.
Embodiment 24
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times each 2 hours with water extraction, amount of water is 8 times of medical material, merges the water extract, centrifugal (rotating speed is 5000 rev/mins), filter, filtrate is 6000 polysulfone membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.18-1.30), adds adjuvant boiling granulating in fluid bed, adds the adjuvant tabletting, promptly obtains tablet of the present invention.
Embodiment 25
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 3 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 3000 rev/mins) filters, filtrate is 6000 SPSF membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.24-1.29), adds adjuvant boiling granulating in fluid bed, adds vegetable oil substrate, and pill promptly obtains drop pill of the present invention.
Embodiment 26
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2.5 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 8000 rev/mins) filters, filtrate is 6000 poly (ether sulfone) film ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression recovery solvent gets fluid extract (proportion is 1.21-1.29), adds adjuvant boiling granulating in fluid bed, adds 200 gram vegetable oil, and mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 27
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 1.5 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 10000 rev/mins) filters, filtrate is 6000 sulfonated polyether sulfone membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.29-1.33), adds adjuvant boiling granulating in fluid bed, pulverizes, and promptly obtains powder of the present invention.
Embodiment 28
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 5000 rev/mins) filters, filtrate is 10000 polysulfonamides membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.28-1.34), adds adjuvant boiling granulating in fluid bed, adds sodium carboxymethyl cellulose, and tabletting promptly obtains dispersible tablet of the present invention.
Embodiment 29
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 1500 rev/mins) filters, filtrate is 6000 phenolphthalein side group polyarylsulfone (PAS) membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.13-1.20), adds adjuvant boiling granulating in fluid bed, promptly gets granular preparation of the present invention.
Embodiment 30
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 3000 rev/mins) filters, filtrate is 6000 Kynoar membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.10-1.14), adds adjuvant boiling granulating in fluid bed, and is encapsulated, promptly obtains capsule preparations of the present invention.
Embodiment 31
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 5000 rev/mins) filters, filtrate is 6000 polyacrylonitrile membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.16-1.19), adds adjuvant boiling granulating in fluid bed, adds the adjuvant tabletting, promptly obtains tablet of the present invention.
Embodiment 32
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 4 times with water extraction, each 1 hour, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 10000 rev/mins) filters, filtrate is 8000 polyimides membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.16-1.20), adds adjuvant boiling granulating in fluid bed, adds vegetable oil substrate, and pill promptly obtains drop pill of the present invention.
Embodiment 33
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2.5 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 15000 rev/mins) filters, filtrate is 6000 cellulose membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression recovery solvent gets fluid extract (proportion is 1.14-1.19), adds adjuvant boiling granulating in fluid bed, adds 200 gram vegetable oil, and mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 34
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 3 times with water extraction, each 1.5 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 2000 rev/mins) filters, filtrate is methyl methacrylate-acrylonitrile copolymer membrane ultrafiltration of 6000 with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.17-1.22), adds adjuvant boiling granulating in fluid bed, pulverizes, and promptly obtains powder of the present invention.
Embodiment 35
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, decoct 2 times with water extraction, each 2 hours, amount of water is 8 times of medical material, merge the water extract, centrifugal (rotating speed is 4000 rev/mins) filters, filtrate is polyacrylonitrile-cellulose diacetate blend film ultrafiltration of 6000 with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.Ultrafiltration gained filtrate decompression reclaims solvent, gets fluid extract (proportion is 1.16-1.20), adds adjuvant boiling granulating in fluid bed, adds sodium carboxymethyl cellulose, and tabletting promptly obtains dispersible tablet of the present invention.
Embodiment 36
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times each 2 hours with water extraction, amount of water is 8 times of medical material, merges the water extract, filters, filtrate is 6000 phenolphthalein side group polyarylsulfone (PAS) membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 1000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.8 times of former ultrafiltrate, get fluid extract (proportion is 1.13-1.18), add adjuvant boiling granulating in fluid bed, promptly get granular preparation of the present invention.
Embodiment 37
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times with water extraction, and each 2 hours, amount of water was 10 times of medical material, merged the water extract, filter, and filtrate is 6000 Kynoar membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.8 times of former ultrafiltrate, get fluid extract (proportion is 1.15-1.21), add adjuvant boiling granulating in fluid bed, encapsulated, promptly obtain capsule preparations of the present invention.
Embodiment 38
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times with water extraction, and each 2 hours, amount of water was 8 times of medical material, merged the water extract, filter, and filtrate is 6000 polyacrylonitrile membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 2000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.6 times of former ultrafiltrate, get fluid extract (proportion is 1.10-1.19), add adjuvant boiling granulating in fluid bed, add the adjuvant tabletting, promptly obtain tablet of the present invention.
Embodiment 39
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times with water extraction, and each 3 hours, amount of water was 10 times of medical material, merged the water extract, filter, and filtrate is 6000 polyimides membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 1000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.6 times of former ultrafiltrate, get fluid extract (proportion is 1.20-1.26), add adjuvant boiling granulating in fluid bed, add vegetable oil substrate, pill promptly obtains drop pill of the present invention.
Embodiment 40
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 2 times with water extraction, and each 2.5 hours, amount of water was 8 times of medical material, merged the water extract, filter, and filtrate is 8000 cellulose membrane ultrafiltration with molecular cut off, filter type employing cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.65 times of former ultrafiltrate, get fluid extract (proportion is 1.19-1.25), add adjuvant boiling granulating in fluid bed, add 200 gram vegetable oil, mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 41
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 3 times each 1.5 hours with water extraction, amount of water is 8 times of medical material, merges the water extract, filters, filtrate is 6000 cellulose diacetate membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 2000 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.85 times of former ultrafiltrate, get fluid extract (proportion is 1.20-1.24), add adjuvant boiling granulating in fluid bed, pulverize, promptly obtain powder of the present invention.
Embodiment 42
The Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae that take by weighing recipe quantity are pulverized, and decoct 4 times each 1.5 hours with water extraction, amount of water is 8 times of medical material, merges the water extract, filters, filtrate is 6000 cellulose diacetate membrane ultrafiltration with molecular cut off, and filter type adopts cross flow filter.The operating condition of ultrafiltration technology is: the inlet pressure of ultrafiltration is 0.1 MPa, and low 0.5 kPa of the liquid outlet pressure ratio inlet pressure of ultrafiltration progressively boosts during ultrafiltration.In ultra-filtration process, adopt the periodic pressure fluctuation, the pressure wave moment is 0.1 MPa.It is to handle in 500 the rolling nanofiltration device that ultrafiltration gained filtrate is selected molecular cut off for use through system, wherein the nanofiltration amount of water can be controlled in about 0.7 times of former ultrafiltrate, get fluid extract (proportion is 1.18-1.23), add adjuvant boiling granulating in fluid bed, add sodium carboxymethyl cellulose, tabletting promptly obtains dispersible tablet of the present invention.
Determining of the amount of experimental example 1-dry extract of the present invention
Fluid extract with the embodiment 1-42 among the present invention does not add adjuvant, and directly lyophilization obtains dry extract, and data are as follows:
By realization of the present invention, can be under the prerequisite that the effective ingredient in the Herba Artemisiae Scopariae Decoction is extracted to greatest extent, reducing in the extract macromolecular substances such as impurity such as tannin, polyphenol, resin, protein, phlegmatic temperament and solid particle effectively removes, keep the active ingredient in Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae, for the preparation of oral drug preparation is provided convenience.
Gardenoside assay in the experimental example 2-dry extract of the present invention
1 material and instrument
1.1 material
Embodiment 1-42 fluid extract (not adding adjuvant) is lyophilization gained dry extract directly.Methanol is chromatographic grade; Other reagent is analytical pure.
1.2 instrument
SPD-10AVP type high performance liquid chromatograph (day island proper Tianjin company); LibrorAEG-200 electronic balance (day island proper Tianjin company); LS-3120 supersonic generator (U.S. scientific system company).
2 assays
2.1 chromatographic condition
Water)=25:75 is a mobile phase (5 μ m, 4.6mm * 200mm) are chromatographic column to DiamonsilTM C18, and (methanol:, the detection wavelength is 238nm, and flow velocity is 1.0 ml/min with ψ.The result
2.2 reagent
Methanol (chromatographically pure), ammonium acetate (analytical pure), glacial acetic acid (analytical pure), distilled water, gardenoside reference substance
2.3 the investigation of the range of linearity
The preparation precision of reference substance stock solution takes by weighing 25 milligrams of gardenoside reference substances, puts in 50 milliliters of measuring bottles, adds dissolve with methanol and is diluted to scale, shakes up, and makes per 1 milliliter of solution that contains 1 milligram, in contrast the product stock solution.Accurate above-mentioned reference substance stock solution (1 milligram/1 milliliter) 0.1,0.5,1.0,2.0,5.0,8.0,10.0 milliliters of drawing is put in 10 milliliters of measuring bottles, adds methanol and is diluted to scale, shakes up.The therefrom accurate respectively 10 μ l that draw inject chromatograph of liquid, the record peak area.The range of linearity of gardenoside is 0.2884～1.4420 μ g (r=0.9998), and average recovery rate (n=5) is 98.6%, and RSD is 0.92%.
2.4 the preparation of reference substance solution: precision takes by weighing 25 milligrams of gardenoside reference substances, put in 50 milliliters of measuring bottles, add dissolve with methanol and be diluted to scale, shake up, accurate again absorption is put in 50 milliliters of measuring bottles for 10 milliliters, adds dissolve with methanol and is diluted to scale, shakes up, make per 1 milliliter of solution that contains 0.1 milligram, in contrast product solution.
2.5. the preparation of need testing solution: get the about 0.25g of sample of the present invention (embodiment 1-42), porphyrize.Precision takes by weighing, and puts in 50 milliliters of measuring bottles, adds about 45 milliliters of methanol, and supersound extraction is 60 minutes respectively, the cooling back is diluted to scale with methanol, shakes up, and leaves standstill, and gets supernatant and filters with microporous filter membrane (0.45 μ m), discard filtrate just, get subsequent filtrate 10 μ l, inject chromatograph of liquid, the results are shown in Table 1.
The table 1 sample ultrasonic time is investigated
3. conclusion: guaranteed the stable content of gardenoside among the present invention, for the standardization production of preparation is laid a good foundation.By realization of the present invention, can be under the prerequisite that the effective ingredient in the Herba Artemisiae Scopariae Decoction is extracted to greatest extent, reducing in the extract macromolecular substances such as impurity such as tannin, polyphenol, resin, protein, phlegmatic temperament and solid particle effectively removes, keep the active ingredient in Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and the Fructus Gardeniae, for the preparation of oral drug preparation is provided convenience.
Claims (9)
1. the preparation method of a Herba Artemisiae Scopariae Decoction preparation, its prescription consists of Fructus Gardeniae 200-400 part, Herba Artemisiae Scopariae 300-600 part, Radix Et Rhizoma Rhei 50-150 part is characterized in that, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei and Fructus Gardeniae are decocted with water 1-4 time, each 0.5-3 hour, merge decocting liquid, filter the back concentrate fluid extract, add behind the adjuvant with behind the fluidized bed granulation useful in preparing drug formulations.
2. preparation method according to claim 1, the proportion that it is characterized in that described fluid extract is 1.10-1.35.
3. preparation method according to claim 2, the proportion that it is characterized in that described fluid extract is 1.15-1.30.
4.. preparation method according to claim 1 is characterized in that described decocting liquid can carry out centrifugation earlier, gets clarifying decocting liquid, centrifugal rotation speed is 1500-20000 rev/min.
5. according to the arbitrary described preparation method of claim 1-4, it is characterized in that described decocting liquid can adopt the method for membrane filtration to filter.
6. preparation method according to claim 5 is characterized in that described membrane filtration comprises ultrafiltration and nanofiltration.
7. preparation method according to claim 6, the process that it is characterized in that described membrane filtration is carried out nanofiltration again for the process ultrafiltration earlier of decocting liquid.
8. according to the arbitrary described preparation method of claim 1-7, it is characterized in that described adjuvant is selected from microcrystalline Cellulose, powdery cellulose, mannitol, starch, lactose, gelatin, methylcellulose, dextrin, pregelatinized Starch, micropowder silica gel, hydroxypropyl methylcellulose, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, Polyethylene Glycol, xylitol, lactose, glucose, glycine, mannitol, tartaric acid, silicon dioxide, one or more in calcium stearate and the magnesium stearate.
9. according to the arbitrary described preparation method of claim 1-7, it is characterized in that described pharmaceutical preparation comprises granule, tablet, capsule, powder, drop pill.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101461503A CN101371882A (en) | 2007-08-24 | 2007-08-24 | Method for preparing Artemisia capillaris decoction formulation |
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| CNA2007101461503A CN101371882A (en) | 2007-08-24 | 2007-08-24 | Method for preparing Artemisia capillaris decoction formulation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101940642A (en) * | 2010-10-08 | 2011-01-12 | 华东理工大学 | Chinese medicinal composition and application thereof |
| CN102028701A (en) * | 2010-12-29 | 2011-04-27 | 王喜军 | Active ingredient composition for treating alcoholic liver injury |
| CN103230453A (en) * | 2013-04-19 | 2013-08-07 | 康美药业股份有限公司 | Yinchengao Decoction formula particles, and preparation method and detection method thereof |
| CN104922218A (en) * | 2015-07-01 | 2015-09-23 | 臧海阳 | Traditional Chinese medicine composition for treating exuberant heat toxin type of infantile jaundice |
| CN104971246A (en) * | 2015-06-30 | 2015-10-14 | 谭清平 | Traditional Chinese medicine decoction for treating neonatal pathologic jaundice |
| CN110090251A (en) * | 2019-06-03 | 2019-08-06 | 扬子江药业集团上海海尼药业有限公司 | A kind of preparation method of Artemisia capillaris piece |
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2007
- 2007-08-24 CN CNA2007101461503A patent/CN101371882A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940642A (en) * | 2010-10-08 | 2011-01-12 | 华东理工大学 | Chinese medicinal composition and application thereof |
| CN101940642B (en) * | 2010-10-08 | 2013-05-22 | 华东理工大学 | Chinese medicinal composition and application thereof |
| CN102028701A (en) * | 2010-12-29 | 2011-04-27 | 王喜军 | Active ingredient composition for treating alcoholic liver injury |
| CN102028701B (en) * | 2010-12-29 | 2012-09-19 | 王喜军 | Active ingredient composition for treating alcoholic liver injury |
| CN103230453A (en) * | 2013-04-19 | 2013-08-07 | 康美药业股份有限公司 | Yinchengao Decoction formula particles, and preparation method and detection method thereof |
| CN104971246A (en) * | 2015-06-30 | 2015-10-14 | 谭清平 | Traditional Chinese medicine decoction for treating neonatal pathologic jaundice |
| CN104922218A (en) * | 2015-07-01 | 2015-09-23 | 臧海阳 | Traditional Chinese medicine composition for treating exuberant heat toxin type of infantile jaundice |
| CN110090251A (en) * | 2019-06-03 | 2019-08-06 | 扬子江药业集团上海海尼药业有限公司 | A kind of preparation method of Artemisia capillaris piece |
| CN110090251B (en) * | 2019-06-03 | 2021-07-06 | 扬子江药业集团上海海尼药业有限公司 | Preparation method of artemisia capillaris tablet |
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Open date: 20090225 |