CN101229236A - Relieve asthma oral liquid preparation and preparing method thereof - Google Patents
Relieve asthma oral liquid preparation and preparing method thereof Download PDFInfo
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- CN101229236A CN101229236A CNA2008100078424A CN200810007842A CN101229236A CN 101229236 A CN101229236 A CN 101229236A CN A2008100078424 A CNA2008100078424 A CN A2008100078424A CN 200810007842 A CN200810007842 A CN 200810007842A CN 101229236 A CN101229236 A CN 101229236A
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Abstract
The invention relates to an oral preparation of asthma-relieving decoction which is prepared by ginkgo seeds and other eight Chinese medicines mainly for asthma treatment and the preparation method thereof; according to conventional processes, the invention is prepared by mixed tracts (extractum or dry powders and volatile oils), which are utilized as raw materials and formed by ginkgo seeds, ephedra, perilla fruits, coltsfoot flowers, almond, cortex mori, scutellaria, pinellia ternate and glycyrrhiza, together with the vectors or the excipient, which are utilized as matrix and acceptable in pharmacy. The preparation has the efficacies of ventilating lung, lowering qi, clearing away heat and eliminatingsputum and mainly treats wind and cold affecting superficies and ashma causing accumulation of phlegm-heat. The long-term clinical application shows that the oral preparation has a very good therapeutic effects on bronchial asthma and chronic bronchial asthma, etc.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of relieve asthma oral liquid preparation that cures mainly asthma and preparation method thereof, particularly the extract with DINGCHUAN TANG Chinese medicine Cheng Fang is the oral formulations of active constituents of medicine.
Background technology
Formulate in " DINGCHUAN TANG " thorough when opening " the many wonderful recipes of health preserving " for the Ming Dynasty, always as accumulation of phlegm-heat in the interior, the side commonly used of the cough with asthma of impaired depurative descending of lung QI, by Semen Ginkgo, Herba Ephedrae, Fructus Perillae, Flos Farfarae, Semen Armeniacae Amarum, Cortex Mori, Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae is formed, has dispersing and descending lung-QI, the effect of removing heat-phlegm cures mainly the exterior tightened by pathogenic windcold, the asthma card of accumulation of phlegm-heat in the interior.This prescription long-term clinical application shows that to bronchial asthma, chronic bronchial asthma etc. have better curative effect, and has application widely, finds that also significantly secondary of poison should.
The source of selected Chinese crude drug is as follows in " DINGCHUAN TANG ":
Semen Ginkgo: be the dry mature fruit of Ginkgoaceae plant Ginkgo biloba.Astringing lung QI for relieving asthma is arranged, and leukorrhagia stopping is turbid, the effect of urine reducing.
Herba Ephedrae: be the dry herb stem of Ephedra sinica, epheday intermedia or ephedra equisetina.Have the diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema eliminates the phlegm, and is analgesic, antibiotic, antiviral, stimulating central nervous system, effects such as rising blood pressure.
Fructus Perillae: this product is the dry mature fruit of labiate Folium Perillae.The sending down the abnormal ascending QI expectorant is relievingd asthma, the effect of intestine moistening.
Flos Farfarae: be the dry flower of feverfew coltsfoot.Nourishing the lung to keep the adverse QI downward, the effect of relieving cough and resolving phlegm.
Semen Armeniacae Amarum: be the rosaceous plant Prunus armeniaca L.var.ansu Maxim., Siberia Fructus Pruni, the dry mature seed of prunus mandshuricaKoehne.The sending down the abnormal ascending QI relieving cough and asthma is arranged, the effect of loosening bowel to relieve constipation.
Cortex Mori: be the dry root bark of moraceae plants Mulberry.Eliminating pathogen from the lung for relieving asthma is arranged, the effect of inducing diuresis to remove edema.
Radix Scutellariae: be the root of labiate Radix Scutellariae.The removing the relative excess fire is arranged, remove damp and hot, hemostasis, antiabortive effect.
The Rhizoma Pinelliae: the tuber of the aroid Rhizoma Pinelliae.Drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass.
Radix Glycyrrhizae: be the leguminous plant Radix Glycyrrhizae, the dry root and rhizome of expand dried fruits grass or light dried fruits grass.Invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain and coordinating the actions of various ingredients in a prescription.
Side's epheday intermedia dispersing and lowering lung-QI is with Dingchuan, the double exterior cold of separating, and the Semen Ginkgo astringing lung-QI and relieving cough, resolving phlegm and relieving asthma, two medicines one are received one and are loose, and are principal agent altogether; Semen Armeniacae Amarum, Fructus Perillae, the Rhizoma Pinelliae, Flos Farfarae lowering the adverse-rising QI to resolve phlegm, the merit that reinforcement is relievingd asthma is accessory drugs; Radix Scutellariae, Cortex Mori eliminating heat from the lung are with relieving cough and asthma.
Ancient times, DINGCHUAN TANG had only decoction, decoct behind the needs purchase decoction pieces and take, carry take all very inconvenient, we quantitatively control by index components and make the modern Chinese medicine oral formulations through studying, and product dosage is accurate, steady quality, conveniently take, be applicable to the big production of commercialization, overcome that the Chinese medicine decoction consumption is big, consumption is inaccurate, carry take inconvenience, can't commercialization etc. shortcoming, the needs that make things convenient for clinical treatment and family to use.
Summary of the invention
The objective of the invention is to preparation method according to modern Chinese medicine, quantitatively control by index components and to make the modern Chinese medicine oral formulations, with DINGCHUAN TANG be developed to product dosage accurately, steady quality, conveniently take, be applicable to the Chinese patent medicine of the big production of commercialization, make things convenient for clinical treatment and family to use.
The medicine of oral formulations involved in the present invention is by Semen Ginkgo, Herba Ephedrae, Fructus Perillae, Flos Farfarae, Semen Armeniacae Amarum, Cortex Mori, Radix Scutellariae, the Rhizoma Pinelliae, the mixed extract of Radix Glycyrrhizae (comprise water extract: extractum or dry powder and volatile oil) is raw material, with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, each flavour of a drug and weight fraction (unit is g or kg) are in preparation the present invention prescription:
Each flavour of a drug and weight fraction (unit is g or kg) are in preparation the present invention prescription:
Semen Ginkgo 1-20 part, Herba Ephedrae 1-20 part, Fructus Perillae 1-15 part, Flos Farfarae 1-20 part, Semen Armeniacae Amarum 1-20 part, Cortex Mori 1-20 part, Radix Scutellariae 1-15 part, Rhizoma Pinelliae 1-20 part, Radix Glycyrrhizae 1-8 part
Preparing in the optimizing prescriptions of the present invention each flavour of a drug and weight fraction (unit is g or kg) is:
Semen Ginkgo 2-15 part, Herba Ephedrae 2-15 part, Fructus Perillae 1-12 part, Flos Farfarae 2-15 part, Semen Armeniacae Amarum 2-15 part, Cortex Mori 2-15 part, Radix Scutellariae 1-12 part, Rhizoma Pinelliae 2-15 part, Radix Glycyrrhizae 1-6 part
Each flavour of a drug and weight fraction (unit is g or kg) are in the best optimizing prescriptions of preparation the present invention:
9 parts of Semen Ginkgoes, 9 parts in Herba Ephedrae, 6 parts of Fructus Perillaes, 9 parts of Flos Farfaraees, 9 parts in Semen Armeniacae Amarum, 6 parts of Cortex Mori, 6 parts of Radix Scutellariaes, 9 parts of the Rhizoma Pinelliaes, 3 parts in Radix Glycyrrhizae
Substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;
Proportioning: extract (comprise water extract: extractum or dry powder and volatile oil): substrate=9: 1～1: 9.
The extraction process of DINGCHUAN TANG mixed extract of the present invention (water extract and volatile oil) is as follows:
(1) each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, and reclaims volatile oil;
(2) aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;
(3) DINGCHUAN TANG extract (water extract and volatile oil) and pharmaceutically acceptable carrier or excipient composition routinely technology make various oral administration solids or liquid preparation, wherein said carrier or excipient pharmaceutically selected according to different dosage forms, and these used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The extracting method of DINGCHUAN TANG extract of the present invention is a lot, has only provided a kind of method here, but is not limited to this kind method.
Medicine of the present invention, wherein dosage form comprises oral solid formulation and oral liquid, wherein oral solid formulation comprises: tablet, hard capsule, liquid type capsule, granule, soft capsule, drop pill, pill, pellet, slow releasing preparation; Oral liquid comprises: oral liquid, syrup, medicated wine; Granule wherein, oral liquid, hard capsule and additive of tablet are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate, mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, polyethylene compares pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more; Wherein the adjuvant of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C
5-C
14Triglyceride, in the ethyl oleate one or more, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
Pharmaceutical preparation of the present invention wherein can also contain aromatic and antiseptic, and wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
The DINGCHUAN TANG method for preparing extractive is as follows:
Prescription: 9 parts of Semen Ginkgoes, 9 parts in Herba Ephedrae, 6 parts of Fructus Perillaes, 9 parts of Flos Farfaraees, 9 parts in Semen Armeniacae Amarum, 6 parts of Cortex Mori, 6 parts of Radix Scutellariaes, 9 parts of the Rhizoma Pinelliaes, 3 parts in Radix Glycyrrhizae
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and take by weighing each medical material of recipe quantity and add 6～20 times of water gagings and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, collection volatile oil; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying is that dry powder is that water extract is standby.
Preparation relieve asthma oral liquid liquid and syrup
DINGCHUAN TANG extract and correctives, antiseptic and water are made oral liquid, and wherein correctives is selected from one or more in sucrose, saccharin sodium, sodium cyclamate, stevioside, aspartoyl aminotoluene acid methyl ester, the Oleum menthae (alcohol); Antiseptic is selected from sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more.
The preparation method of oral liquid and syrup is as follows: the DINGCHUAN TANG extract adds water to be adjusted to preparation amount, adds correctives, antiseptic mix homogeneously, through technologies such as sterilization, fill, check, packings, promptly gets jichuan decoction oral liquid and syrup.
Wherein the weight percent content of Jia Ruing is: DINGCHUAN TANG extract 5-80%, correctives 0.05-5%, antiseptic 0.001-2%, water 10-90%.
Preparation DINGCHUAN TANG granule, pill, pellet, capsule, tablet
Granule, pill, pellet, capsule, and tablet are made the used adjuvant of concentrated granule or pill or tablet and are comprised diluent, binding agent, lubricant; Diluent is selected from one or more of starch, lactose, dextrin, microcrystalline Cellulose kind; Binding agent comprise water, macromolecular material and alcoholic acid one or more; Lubricant comprises one or more in magnesium stearate, Pulvis Talci, the stearic acid.
Granule, pill, pellet, capsule, and the preparation method of tablet as follows:
With DINGCHUAN TANG extract and an amount of pharmaceutic adjuvant mixing, adding binding agent etc. is made soft material, makes granule with granulator, and dry, granulate promptly gets granule, or the general pill of making, or makes capsule through capsule filling machine, or makes tablet through tabletting.
Granule, pill, pellet, capsule, and tablet, wherein every gram granule is equivalent to contain the crude drug amount of 0.1-10 gram.
Preparation DINGCHUAN TANG soft capsule
With DINGCHUAN TANG extract and adjuvant diluent, antioxidant, antiseptic, suspending agent, wherein diluent is selected from one or more in Polyethylene Glycol, propylene glycol, vegetable oil, the mineral oil; Antioxidant is selected from that glycine, vitamin E and derivant thereof, ascorbic acid, pyrosulfurous acid are received, in the potassium metabisulfite one or more; Antiseptic comprises sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more; Suspending agent is selected from one or more in chitin, cellulose family, agar, the Cera Flava.
Preparation method is as follows: DINGCHUAN TANG extract 5-50%, add an amount of diluent, antioxidant, antiseptic, suspending agent mix homogeneously, prepared forms routinely, and wherein every gram soft capsule is equivalent to contain the crude drug amount of 0.1-10 gram.
Specific embodiment
Embodiment one: DINGCHUAN TANG extract (extractum and volatile oil) preparation method
Prescription: Semen Ginkgo 9g, Herba Ephedrae 9g, Fructus Perillae 6g, Flos Farfarae 9g, Semen Armeniacae Amarum 9g, Cortex Mori 9g, Radix Scutellariae 4.5g, Rhizoma Pinelliae 9g, Radix Glycyrrhizae 3g
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 10～15 times of water gagings and soaks 2-10 hour, heat little boiling and extracts 2-3 time, and volatile oil is collected in the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and it is the about 20.5g of water extract that concentrating under reduced pressure gets extractum, the about 0.2g of volatile oil.
Embodiment two: relieve asthma oral liquid solid preparation preparation method
(1) preparation DINGCHUAN TANG granule
Prescription:
DINGCHUAN TANG extract 10-90%
Starch 5.0-70%
Dextrin 2.0-20%
Xylitol 5.0-20%
Sorbic acid methyl ester 0.001-2.0%
Optimizing prescriptions:
DINGCHUAN TANG extract 20.7g
Starch 8.0g
Dextrin 8.0g
Xylitol 4.0g
Sorbic acid methyl ester 0.002g
Method for making: prepare bavin DINGCHUAN TANG extract by the method among the embodiment one, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, and every bag of 10g is packed promptly in cold drying.
(2) preparation DINGCHUAN TANG effervescent tablet
Prescription: DINGCHUAN TANG extract 20.7
Starch 5g
Dextrin 5g
Microcrystalline Cellulose 3g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Anhydrous citric acid 5.0g
Sodium bicarbonate 5.0g
Lactose 5.0g
Water is an amount of
Method for making: prepare bavin DINGCHUAN TANG extract by the method among the embodiment one, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(3) preparation DINGCHUAN TANG pill
Prescription:
DINGCHUAN TANG extract 20.7g
Starch 10g
Magnesium stearate 0.5g
Dextrin 5g
Water is an amount of
Method for making: prepare bavin DINGCHUAN TANG extract by the method among the embodiment one, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and pelleting is promptly.
(4) preparation DINGCHUAN TANG soft capsule
The content prescription:
DINGCHUAN TANG extract 20.7g
Vegetable oil 20g
Polyoxyethylene monostearate 2.5g
Ethylparaben 0.02g
Cera Flava 6g
Method for making: prepare the DINGCHUAN TANG extract by the method among the embodiment one, the vegetable oil of adding optimizing prescriptions percentage amounts, Cera Flava, polyoxyethylene monostearate, ethylparaben prepared routinely form.
(5) preparation DINGCHUAN TANG capsule
Prescription:
DINGCHUAN TANG extract 10-95%
Starch 5-55%
Magnesium stearate 0.1-5%
Optimizing prescriptions:
DINGCHUAN TANG extract 2 20.7g
Starch 10g
Magnesium stearate 1.5g
Method for making: prepare bavin DINGCHUAN TANG extract by the method among the embodiment one, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, and cold drying, fill are promptly.
Embodiment three: relieve asthma oral liquid liquid preparation preparation method
(1) oral liquid preparation
Prescription: DINGCHUAN TANG extract 5-80%
Sucrose 5.0-50%
Sodium cyclamate 5.0-40%
Sorbic acid methyl ester 0.001-2%
Span 20 5.0-40%
Distilled water 10-90%.
Optimizing prescriptions:
DINGCHUAN TANG extract 20.7g
Sucrose 5.0g
Sodium cyclamate 1.5g
Span 20 2.5g
Sorbic acid methyl ester 0.02g
Distilled water is settled to 60ml.
Method for making: prepare the DINGCHUAN TANG extract by the method among the embodiment one, add each adjuvant of prescription and distilled water, again through the ultrafilter ultrafiltration, the ultrafiltrate fill, sterilization, promptly.
Claims (6)
- One kind by 9 flavor Chinese medicines preparations such as Semen Ginkgo cure mainly DINGCHUAN TANG drug oral preparation of asthma and preparation method thereof, mixed extract (extractum or dry powder and volatile oil) with Semen Ginkgo, Herba Ephedrae, Fructus Perillae, Flos Farfarae, Semen Armeniacae Amarum, Cortex Mori, Radix Scutellariae, the Rhizoma Pinelliae, Radix Glycyrrhizae is a raw material, with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, wherein:1.1 each flavour of a drug and weight fraction (unit is g or kg) are in preparation the present invention prescription:Semen Ginkgo 1-20 part, Herba Ephedrae 1-20 part, Fructus Perillae 1-15 part, Flos Farfarae 1-20 part, Semen Armeniacae Amarum 1-20 part, Cortex Mori 1-20 part, Radix Scutellariae 1-15 part, Rhizoma Pinelliae 1-20 part, Radix Glycyrrhizae 1-8 partEach flavour of a drug and weight fraction in the optimizing prescriptions (unit is g or kg) are:Semen Ginkgo 2-15 part, Herba Ephedrae 2-15 part, Fructus Perillae 1-12 part, Flos Farfarae 2-15 part, Semen Armeniacae Amarum 2-15 part, Cortex Mori 2-15 part, Radix Scutellariae 1-12 part, Rhizoma Pinelliae 2-15 part, Radix Glycyrrhizae 1-6 partEach flavour of a drug and weight fraction (unit is g or kg) are in the best optimizing prescriptions:9 parts of Semen Ginkgoes, 9 parts in Herba Ephedrae, 6 parts of Fructus Perillaes, 9 parts of Flos Farfaraees, 9 parts in Semen Armeniacae Amarum, 6 parts of Cortex Mori, 6 parts of Radix Scutellariaes, 9 parts of the Rhizoma Pinelliaes, 3 parts in Radix Glycyrrhizae1.2 substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;1.3 proportioning: extract (comprise water extract: extractum or dry powder and volatile oil): substrate=9: 1～1: 9.
- 2. according to the DINGCHUAN TANG extract in the claim 1, its preparation technology is as follows:1.1 each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, and collects volatile oil;1.2 aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;1.3 DINGCHUAN TANG water extract and volatile oil and carrier pharmaceutically or adjuvant root make up routinely technology and make various oral administration solids or liquid preparation, these wherein used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
- 3. according to the relieve asthma oral liquid pharmaceutical preparation among the claim 1-2, wherein dosage form comprises tablet, hard capsule, granule, soft capsule, drop pill and oral liquid, wherein:1.1 granule, tablet, hard capsule and oral liquid liquid preparation substrate are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts (mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate), mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more.1.2 the substrate of soft capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C 5-C 14Triglyceride, in the ethyl oleate one or more.
- 4. according to the pharmaceutical preparation among the claim 1-3, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
- 5. according to the pharmaceutical preparation among the claim 1-4, wherein can also contain aromatic and antiseptic, wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
- 6. according to the DINGCHUAN TANG drug oral preparation among the claim 1-5, has dispersing and descending lung-QI, the effect of removing heat-phlegm, cure mainly the exterior tightened by pathogenic windcold, the asthma card of accumulation of phlegm-heat in the interior, this prescription long-term clinical application shows, to bronchial asthma, chronic bronchial asthma etc. have better curative effect.
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| CN104288477A (en) * | 2014-10-29 | 2015-01-21 | 王丽丽 | Traditional Chinese medicine preparation curing infantile asthma |
| CN104398717A (en) * | 2014-12-11 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | Chinese herbal preparation for treating asthma, as well as preparation method and application of Chinese herbal preparation |
| CN104587262A (en) * | 2015-02-02 | 2015-05-06 | 李志� | Traditional Chinese medicine for treatment of bronchial asthma |
| CN105749147A (en) * | 2016-03-01 | 2016-07-13 | 徐立勇 | Medicine for treating hypertension and hyperlipidemia and preparation method of medicine |
| CN107496866A (en) * | 2017-09-04 | 2017-12-22 | 上海市中医医院 | Chinese medicine composition of the treatment childhood asthma containing volatile oil and its preparation method and application |
| CN108420913A (en) * | 2018-05-18 | 2018-08-21 | 大连大学 | A kind of Chinese medicine composition and preparation method thereof for treating asthma |
| CN109260340A (en) * | 2018-10-19 | 2019-01-25 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition and preparation method and application |
| CN109260340B (en) * | 2018-10-19 | 2024-01-19 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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