CN108420913A - A kind of Chinese medicine composition and preparation method thereof for treating asthma - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating asthma Download PDFInfo
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Abstract
The present invention relates to tcm field, the Chinese medicine composition and preparation method thereof of specifically a kind for the treatment of asthma.The Chinese medicine composition is made of the raw material of following parts by weight：25 ~ 50 parts of Selaginella tamariscina, 15 ~ 30 parts of Chinese ephedra, 10 ~ 25 parts of the root bark of white mulberry, 10 ~ 20 parts of scutellaria, 20 ~ 30 parts of perillaseed, 15 ~ 30 parts of the tuber of pinellia, 1 ~ 10 part of almond, 10 ~ 15 parts of tussilago, 1 ~ 5 part of Radix Glycyrrhizae.Chinese medicine composition compatibility of the present invention is reasonable, safe and free of toxic and side effects, and no complication, preparation process is simple, significant in efficacy, is suitble to clinically large-scale use.
Description
Technical field
The present invention relates to tcm field, the Chinese medicine composition and preparation method thereof of specifically a kind for the treatment of asthma.
Background technology
Asthma be it is a kind of there are the diseases of airway constriction, caused by the airway hyperreactivity that certain inflammatory stimulus generate, roar
Asthma is a kind of common disease, frequently-occurring disease, is participated in by various kinds of cell especially mast cell, eosinophil and lymphocyte
Chronic airway inflammation, such inflammation can cause panting for recurrent exerbation in susceptible person, the symptoms such as shortness of breath, uncomfortable in chest and/or cough,
Small number of patients is also possible to pectoralgia be main performance.Incidence in adult is about 5%.Asthma has Familial aggregation tendency, grinds
Study carefully and show that the incidence of asthma in urban population is higher, and in Adults Asthma, the incidence higher of women.Such symptom
It is often accompanied by extensive and changeable airflow obstruction, can be reversed voluntarily or by treatment.Currently, medical field is to treating asthma without spy
Drug is imitated, it is palliative, so that many long-term illness of patient are not cured, prodigious physiology and psychological pressure are caused to patient.
Treatment asthma although the treatment works well for it, will produce mainly by the way of western medicine at present
Certain toxic side effect, and cannot tackling the problem at its root, it is very high thus to cause this kind of palindromia rate, to suffering from
Person brings prodigious stress.
Invention content
It is an object of the invention to overcome the defect of problem above, provide a kind of Selaginella tamariscina be used to treat asthma capsule and
Preparation method.
For achieving the above object, the present invention uses following technical scheme：
A kind of Chinese medicine composition for treating asthma, the Chinese medicine composition are made of the raw material of following parts by weight：Selaginella tamariscina 25 ~ 50
Part, 15 ~ 30 parts of Chinese ephedra, 10 ~ 25 parts of the root bark of white mulberry, 10 ~ 20 parts of scutellaria, 20 ~ 30 parts of perillaseed, 15 ~ 30 parts of the tuber of pinellia, 1 ~ 10 part of almond,
10 ~ 15 parts of tussilago, 1 ~ 5 part of Radix Glycyrrhizae.
Further, the dosage form of the Chinese medicine composition is capsule.
The preparation method for treating the Chinese medicine composition of asthma, includes the following steps：
(1) by Selaginella tamariscina, Chinese ephedra, the root bark of white mulberry, scutellaria, perillaseed, the tuber of pinellia, almond, tussilago, Radix Glycyrrhizae is cleaned, dedusting, is dried,
Water is added to be decocted, decocts 3 times repeatedly, merges 3 decoction liquors；
(2) it is concentrated after filtering the decoction liquor obtained in step (1), ethyl alcohol is added in concentrate makes alcohol content be 80%, stirs
It mixes, stands 48h, the filtrate of filtering；
(3) it by the decompression filtrate recycling ethanol obtained in step (2) to no alcohol taste, is evaporated, crushes, 60 mesh excessively sieve to obtain Chinese medicine group
Object powder is closed, it is spare；
(4) excipient is added in the Chinese medicine composition powder for obtaining step (3), and capsule is made in mixing.
Further, first time amount of water is 8 times of medicinal material total volume in step (1), decocts 3h, and second of amount of water is
6 times of medicinal material total volume decoct 2h, and the 3rd amount of water is 5 times of medicinal material total volume, decocts 1.5h.
Further, it is 1.10 ~ 1.15 (60 DEG C) to be concentrated into relative density in step (2) after decoction liquor filtering.
Further, the excipient being added in step (4) is dextrin, and the mass ratio of Chinese medicine composition powder and dextrin is
1:3。
The Chinese medicine composition for the treatment of asthma is applied in treating asthmatic medicament.
In the present invention, the effect of each Chinese medicine material medicinal material, is as follows：
Selaginella tamariscina：Acrid flavour.It is mild-natured.Return liver, the heart channel of Hang-Shaoyin.With invigorate blood circulation；The effect of Selaginella tamariscina charcoal removing blood stasis and hemostasis.
Chinese ephedra：Acrid flavour, slight bitter.It is warm-natured.Return lung, bladder warp.Have effects that sweating cold dispelling, freeing lung and relieving asthma, inducing diuresis for removing edema.
The root bark of white mulberry：It is sweet in flavor, pungent.It is cold in nature.Return lung, the spleen channel.With removing heat from lung and relieving asthma, the effect of inducing diuresis for removing edema.
Scutellaria：It is bitter, cold in nature.Return lung, courage, spleen, large intestine, small intestinl channel.With heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis
The effect of.
Perillaseed：It is acrid flavour, warm-natured.It is distributed in lung channel.Has effects that relieving cough and asthma, sending down abnormally ascending dissolving phlegm.
The tuber of pinellia：It is acrid flavour, warm-natured.Returns spleen, stomach, lung channel.With eliminating dampness and eliminating phlegm, the effect of stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.
Almond：It is bitter, warm-natured.Returns spleen, stomach, large intestine channel.Have effects that it is relieving cough and asthma, relax bowel.
Tussilago：It is acrid flavour, sweet.It is warm-natured.It is distributed in lung channel.With moistening the lung and relieve the cough, under dissolving phlegm the effect of gas.
Radix Glycyrrhizae：It is sweet in flavor.It is mild-natured.The thoughts of returning home, lung, spleen, stomach.It is all with clearing heat and detoxicating, cough-relieving apophlegmatic, tonifying spleen and stomach, reconciliation
The effect of medicine.
Selaginella tamariscina has antasthmatic effect, and Chinese ephedra is as traditional relieving cough and asthma Chinese medicine, so this two tastes Chinese medicine is common
For monarch drug in a prescription, ministerial drug drops clearly lung qi with the root bark of white mulberry, scutellaria to relieving asthma, and has heat-clearing；Assistant reinforces monarch drug in a prescription with perillaseed, almond,
Depressing Qi and relieving asthma is to use, and the tuber of pinellia, tussilago are relievingd asthma with eliminating phlegm and lowering adverse QI；Make with Radix Glycyrrhizae coordinating the drug actions of a prescription, lung is given birth in tonifying spleen.
Specific implementation mode
With reference to specific example, invention is further described in detail.
Embodiment 1
A kind of capsule for treating asthma, includes the raw material components of following parts by weight：Selaginella tamariscina 25g, Chinese ephedra 15g, root bark of white mulberry 10g,
Scutellaria 10g, perillaseed 20g, tuber of pinellia 15g, almond 5g, tussilago 10g, Radix Glycyrrhizae 3g.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, includes the following steps：
(1) by Selaginella tamariscina, Chinese ephedra, the root bark of white mulberry, scutellaria, perillaseed, the tuber of pinellia, almond, tussilago, Radix Glycyrrhizae is cleaned, dedusting, is dried,
Water is added to be decocted, carries out 3 times repeatedly, obtains decoction liquor, first time amount of water is 8 times of medicinal material total volume, is decocted
3h, second of amount of water are 6 times of medicinal material total volume, decoct 2h, and the 3rd amount of water is 5 times of medicinal material total volume, is decocted
1.5h。
(2) merge 3 decoction liquors, be filtered, filtrate is concentrated, it is 1.10- to concentrate the filtrate to relative density
1.15(60℃).Ethyl alcohol is added in concentrate, it is 80% to make alcohol content, is stirred, and places 48h, is filtered.
(3) by above-mentioned decompression filtrate recycling ethanol to no alcohol taste, the sieve be evaporated, crush, crossing 60 mesh is spare.
(4) a certain amount of excipient is added in above-mentioned powder, the excipient of addition is dextrin, and the amount of addition is powder：Paste
Essence=1:3, after mixing, it is made capsule, 2.5g/.
Embodiment 2
A kind of capsule for treating asthma, includes the raw material components of following parts by weight：Selaginella tamariscina 30g, Chinese ephedra 20g, root bark of white mulberry 12g,
Scutellaria 13g, perillaseed 22g, tuber of pinellia 20g, almond 5g, tussilago 13g, Radix Glycyrrhizae 3g.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, includes the following steps：
(1) by Selaginella tamariscina, Chinese ephedra, the root bark of white mulberry, scutellaria, perillaseed, the tuber of pinellia, almond, tussilago, Radix Glycyrrhizae is cleaned, dedusting, is dried,
Water is added to be decocted, carries out 3 times repeatedly, obtains decoction liquor, first time amount of water is 8 times of medicinal material total volume, is decocted
3h, second of amount of water are 6 times of medicinal material total volume, decoct 2h, and the 3rd amount of water is 5 times of medicinal material total volume, is decocted
1.5h。
(2) merge 3 decoction liquors, be filtered, filtrate is concentrated, it is 1.10- to concentrate the filtrate to relative density
1.15(60℃).Ethyl alcohol is added in concentrate, it is 80% to make alcohol content, is stirred, and places 48h, is filtered.
(3) by above-mentioned decompression filtrate recycling ethanol to no alcohol taste, the sieve be evaporated, crush, crossing 60 mesh is spare.
(4) a certain amount of excipient is added in above-mentioned powder, the excipient of addition is dextrin, and the amount of addition is powder：Paste
Essence=1:3, after mixing, it is made capsule, 2.5g/.
Embodiment 3
A kind of capsule for treating asthma, it is made of following raw material：Selaginella tamariscina 35g, Chinese ephedra 25g, 15g parts of the root bark of white mulberry,
Scutellaria 15g, perillaseed 25g, tuber of pinellia 23g, almond 5g, tussilago 14g, Radix Glycyrrhizae 4g.
The capsule preparation method thereof of above-mentioned treatment asthma, includes the following steps：
(1) by Selaginella tamariscina, Chinese ephedra, the root bark of white mulberry, scutellaria, perillaseed, the tuber of pinellia, almond, tussilago, Radix Glycyrrhizae is cleaned, dedusting, is dried,
Water is added to be decocted, carries out 3 times repeatedly, obtains decoction liquor, first time amount of water is 8 times of medicinal material total volume, is decocted
3h, second of amount of water are 6 times of medicinal material total volume, decoct 2h, and the 3rd amount of water is 5 times of medicinal material total volume, is decocted
1.5h。
(2) merge 3 decoction liquors, be filtered, filtrate is concentrated, it is 1.10- to concentrate the filtrate to relative density
1.15(60℃).Ethyl alcohol is added in concentrate, it is 80% to make alcohol content, is stirred, and places 48h, is filtered.
(3) by above-mentioned decompression filtrate recycling ethanol to no alcohol taste, the sieve be evaporated, crush, crossing 60 mesh is spare.
(4) a certain amount of excipient is added in above-mentioned powder, the excipient of addition is dextrin, and the amount of addition is powder：Paste
Essence=1:3, after mixing, it is made capsule, 2.5g/.
Embodiment 4
A kind of capsule for treating asthma, it is made of following raw material：Selaginella tamariscina 50g, Chinese ephedra 30g, 25g parts of the root bark of white mulberry,
Scutellaria 15g, perillaseed 25g, tuber of pinellia 23g, almond 5g, tussilago 14g, Radix Glycyrrhizae 4g.
The capsule preparation method thereof of above-mentioned treatment asthma, includes the following steps：
(1) by Selaginella tamariscina, Chinese ephedra, the root bark of white mulberry, scutellaria, perillaseed, the tuber of pinellia, almond, tussilago, Radix Glycyrrhizae is cleaned, dedusting, is dried,
Water is added to be decocted, carries out 3 times repeatedly, obtains decoction liquor, first time amount of water is 8 times of medicinal material total volume, is decocted
3h, second of amount of water are 6 times of medicinal material total volume, decoct 2h, and the 3rd amount of water is 5 times of medicinal material total volume, is decocted
1.5h。
(2) merge 3 decoction liquors, be filtered, filtrate is concentrated, it is 1.10- to concentrate the filtrate to relative density
1.15(60℃).Ethyl alcohol is added in concentrate, it is 80% to make alcohol content, is stirred, and places 48h, is filtered.
(3) by above-mentioned decompression filtrate recycling ethanol to no alcohol taste, the sieve be evaporated, crush, crossing 60 mesh is spare.
(4) a certain amount of excipient is added in above-mentioned powder, the excipient of addition is dextrin, and the amount of addition is powder：Paste
Essence=1:3, after mixing, it is made capsule, 2.5g/.
Animal toxicity is tested：
1. take experiment mice 120, half male and half female, 150 ~ 200g of weight is respectively divided into three group 1 ~ 3, every group each 40, every group small
Mouse sign is good, and physiological characteristic is almost the same, is comparable.
2. the capsule that the Selaginella tamariscina for using the embodiment of the present invention 1 ~ 3 to prepare respectively to three groups of mouse treats asthma carries out gavage
Experiment, it is secondary daily, it continuously takes 15 days, observes and records the sign situation of all mouse during the experiment.
After experiment, three groups of mouse is showed no death, and 20 mouse are randomly selected in each group and are dissected,
It was found that the major organs of mouse are showed no abnormal situation, so the capsule is nontoxic, can use safely.
Clinical observation statistics is improved for the conditioning of asthma disease state：
1. case is chosen：Clinically choose the anaphylactia patient 200 made a definite diagnosis, 20 ~ 70 years old age, male 80, women
120, it is divided into three groups of experimental groups 1 ~ 4, every group 50.
2. test method：The capsule for using the embodiment of the present invention 1 ~ 4 to prepare respectively to experimental group 1 ~ 4, three times a day, often
Secondary 1,2.5g/, continuous medication 15 days observes and records the recovery situation of patient.
3. standard：Effectively：Asthma symptoms, sign disappear, and follow-up half a year is without recidivist；It is effective：Asthma symptoms are substantially reduced,
And attack times are reduced；In vain：The state of an illness is without any improvement or aggravates.
4. test data counts：
5. test result：As can be seen from the above experimental data, the capsule for the Selaginella tamariscina treatment asthma that prepared by the present invention is for roaring
The total effective rate for breathing heavily the treatment of disease is 94.5%, and 200 patients have no any adverse reaction, therefore is illustrated, volume of the invention
The capsule that cypress treats asthma is safe and effective drug, has good clinical expansion meaning.
Claims (7)
1. a kind of Chinese medicine composition for treating asthma, which is characterized in that the Chinese medicine composition by following parts by weight raw material system
At：25 ~ 50 parts of Selaginella tamariscina, 15 ~ 30 parts of Chinese ephedra, 10 ~ 25 parts of the root bark of white mulberry, 10 ~ 20 parts of scutellaria, 20 ~ 30 parts of perillaseed, 15 ~ 30 parts of the tuber of pinellia,
1 ~ 10 part of almond, 10 ~ 15 parts of tussilago, 1 ~ 5 part of Radix Glycyrrhizae.
2. a kind of Chinese medicine composition for treating asthma as described in claim 1, which is characterized in that the agent of the Chinese medicine composition
Type is capsule.
3. the preparation method of the Chinese medicine composition for the treatment of asthma as claimed in claim 2, which is characterized in that including following step
Suddenly：
(1) by Selaginella tamariscina, Chinese ephedra, the root bark of white mulberry, scutellaria, perillaseed, the tuber of pinellia, almond, tussilago, Radix Glycyrrhizae is cleaned, dedusting, is dried,
Water is added to be decocted, decocts 3 times repeatedly, merges 3 decoction liquors；
(2) it is concentrated after filtering the decoction liquor obtained in step (1), ethyl alcohol is added in concentrate makes alcohol content be 80%, stirs
It mixes, stands 48h, the filtrate of filtering；
(3) it by the decompression filtrate recycling ethanol obtained in step (2) to no alcohol taste, is evaporated, crushes, 60 mesh excessively sieve to obtain Chinese medicine group
Object powder is closed, it is spare；
(4) excipient is added in the Chinese medicine composition powder for obtaining step (3), and capsule is made in mixing.
4. the preparation method of the Chinese medicine composition for the treatment of asthma as claimed in claim 3, which is characterized in that the in step (1)
Amount of water is 8 times of medicinal material total volume, decocts 3h, and second of amount of water is 6 times of medicinal material total volume, decocts 2h, the 3rd time
Amount of water is 5 times of medicinal material total volume, decocts 1.5h.
5. the preparation method of the Chinese medicine composition for the treatment of asthma as claimed in claim 3, which is characterized in that decocted in step (2)
It is 1.10 ~ 1.15 (60 DEG C) that relative density is concentrated into after boil liquid filtering.
6. the preparation method of the Chinese medicine composition for the treatment of asthma as claimed in claim 3, which is characterized in that add in step (4)
The excipient entered is dextrin, and the mass ratio of Chinese medicine composition powder and dextrin is 1:3.
7. application of the Chinese medicine composition of asthma described in claim 1 in treating asthmatic medicament.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810480307.4A CN108420913A (en) | 2018-05-18 | 2018-05-18 | A kind of Chinese medicine composition and preparation method thereof for treating asthma |
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| CN201810480307.4A CN108420913A (en) | 2018-05-18 | 2018-05-18 | A kind of Chinese medicine composition and preparation method thereof for treating asthma |
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| CN108420913A true CN108420913A (en) | 2018-08-21 |
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| CN201810480307.4A Pending CN108420913A (en) | 2018-05-18 | 2018-05-18 | A kind of Chinese medicine composition and preparation method thereof for treating asthma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109260340A (en) * | 2018-10-19 | 2019-01-25 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition and preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109260340A (en) * | 2018-10-19 | 2019-01-25 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition and preparation method and application |
| CN109260340B (en) * | 2018-10-19 | 2024-01-19 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
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Application publication date: 20180821 |