CN101229304A - Chinese thorowax Shugansan oral preparation and preparing method thereof - Google Patents
Chinese thorowax Shugansan oral preparation and preparing method thereof Download PDFInfo
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- CN101229304A CN101229304A CNA200810007841XA CN200810007841A CN101229304A CN 101229304 A CN101229304 A CN 101229304A CN A200810007841X A CNA200810007841X A CN A200810007841XA CN 200810007841 A CN200810007841 A CN 200810007841A CN 101229304 A CN101229304 A CN 101229304A
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Abstract
The invention relates to an oral preparation of Chaihushugan powder, which is prepared with Chinese thorowax root and other six Chinese medicines mainly for treating stagnation of hepatic qi, and the preparation method thereof. The oral preparation is prepared according to conventional processes and utilizing the mixed extracts (extractum or drymeal and naphtha) of bupleurum, tangerine peel, szechuan lovage rhizome, nutgrass galingale rhizome, bitter orange, peony and radix glycyrrhizae preparata as raw materials, together with vector or excipient which are utilized as matrix and acceptable in pharmacy. The preparation has the effects of relieving liver qi stagnation, promoting qi and relieving pain, and mainly treats liver qi depression. The long-term clinical application of the prescription shows that the oral preparation has a good effect on chronic hepatitis, chronic gastritis and cholecystitis, etc.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of oral formulations that cures mainly irritability stasis and preparation method thereof, particularly the extract with bupleurum powder for relieving liver-qi Chinese medicine prescription is the oral formulations of active constituents of medicine.
Background technology
" bupleurum powder for relieving liver-qi " is initiative among the Ye Wenling " medical science system purport " of the Ming Dynasty, always as the side commonly used of dispersing the stagnated live-QI to relieve the stagnation of QI, and by Radix Bupleuri, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Rhizoma Cyperi, Fructus Aurantii, Radix Paeoniae, Radix Glycyrrhizae Preparata is formed, and has dispersing the stagnated live-QI to relieve the stagnation of QI, and the effect of promoting the circulation of QI to relieve pain cures mainly irritability stasis card.This prescription long-term clinical application shows, to chronic hepatitis, and chronic gastritis, cholecystitis etc. have better curative effect, and have widely and use, and find that also significantly secondary the sending out of poison should.
The source of the Chinese crude drug of bupleurum powder for relieving liver-qi is as follows:
Radix Bupleuri: be the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Reconciling superficies and interior is arranged, dredge the sense liver, the effect of yang invigorating.
Pericarpium Citri Reticulatae: be the dry mature fruit of rutaceae orange and variety thereof.Regulating qi-flowing for strengthening spleen is arranged, the effect of drying dampness to eliminate phlegm.
Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong rhizome.Blood-activating and qi-promoting is arranged, the effect of wind-expelling pain-stopping.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber.Promoting QI circulation for relieving depression are arranged, the effect of menstruction regulating and pain relieving.
Fructus Aurantii: be the rutaceae Citrus aurantium Linn. dry green fruit of variety extremely.Regulating the flow of QI to ease the stomach is arranged, the effect of the stagnant relieving distension of row.
Radix Paeoniae: be the root of ranunculaceae plant Radix Paeoniae.The suppressing the hyperactive liver pain relieving is arranged, nourishing blood for regulating menstruation, the effect of astringing YIN to stop sweating.
Radix Glycyrrhizae Preparata: be the leguminous plant Radix Glycyrrhizae, the dry root and rhizome of expand dried fruits grass or light dried fruits grass.Invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain and coordinating the actions of various ingredients in a prescription.
Fang Zhongyong Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI is a monarch drug.Rhizoma Cyperi is regulated the flow of vital energy soothing the liver, helps Radix Bupleuri to separate stagnation of liver-QI; Rhizoma Chuanxiong promoting flow of QI and blood and pain relieving, help Radix Bupleuri with untie through stasis, two medicines are harmonious, and increase the merit of its promoting the circulation of QI to relieve pain, are ministerial drug.Pericarpium Citri Reticulatae, Fructus Aurantii regulating qi-flowing for activating stagnancy; Radix Paeoniae, Radix Glycyrrhizae nourishing blood to suppress the hyperactive liver, relieving spasm to stop pain is adjuvant drug.Radix Glycyrrhizae is held concurrently and transfers all medicines, also is the usefulness of messenger drug.All medicines are harmonious, altogether long memorial liver circulation of qi promoting, and the merit of promoting blood circulation and stopping pain reaches the irritability bar, unobstructed vessel, the Wei Zihe of battalion, pain is ended and cold and heat also remove.
The bupleurum powder for relieving liver-qi in ancient times does not have only decoction, decoct behind the needs purchase decoction pieces and take, carry take all very inconvenient, we quantitatively control by index components and make the modern Chinese medicine oral formulations through studying, and product dosage is accurate, steady quality, conveniently take, be applicable to the big production of commercialization, overcome that the Chinese medicine decoction consumption is big, consumption is inaccurate, carry take inconvenience, can't commercialization etc. shortcoming, the needs that make things convenient for clinical treatment and family to use.
Summary of the invention
The objective of the invention is to preparation method according to modern Chinese medicine, quantitatively control by index components and to make the modern Chinese medicine oral formulations, with bupleurum powder for relieving liver-qi be developed to product dosage accurately, steady quality, conveniently take, be applicable to the Chinese patent medicine of the big production of commercialization, make things convenient for clinical treatment and family to use.
The medicine of oral formulations involved in the present invention is raw material by the mixed extract of Radix Bupleuri, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Rhizoma Cyperi, Fructus Aurantii, Radix Paeoniae and Radix Glycyrrhizae Preparata (comprise water extract: extractum or dry powder and volatile oil), with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, because it is slightly different to record the bupleurum powder for relieving liver-qi recipe quantity in the different medical books, each flavour of a drug and weight fraction (unit is g or kg) are in preparation the present invention prescription:
Radix Bupleuri 2-10 part, Pericarpium Citri Reticulatae 2-10 part, Rhizoma Chuanxiong 2-8 part, Rhizoma Cyperi 2-8 part, Fructus Aurantii 2-8 part, Radix Paeoniae 2-8 part, Radix Glycyrrhizae Preparata 1-6 part
Each flavour of a drug and weight fraction (unit is g or kg) are in the best optimizing prescriptions:
Radix Bupleuri 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Rhizoma Chuanxiong 4-6 part, Rhizoma Cyperi 4-6 part, Fructus Aurantii 4-6 part, Radix Paeoniae 4-6 part, Radix Glycyrrhizae Preparata 1-3 part;
Substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;
Proportioning: extract (comprise water extract: extractum or dry powder and volatile oil): substrate=9: 1～1: 9.
The extraction process of bupleurum powder for relieving liver-qi mixed extract of the present invention (water extract and volatile oil) is as follows:
(1) each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, and reclaims volatile oil;
(2) aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;
(3) bupleurum powder for relieving liver-qi extract (water extract and volatile oil) and pharmaceutically acceptable carrier or excipient composition routinely technology make various oral administration solids or liquid preparation, wherein said carrier or excipient pharmaceutically selected according to different dosage forms, and these used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The extracting method of bupleurum powder for relieving liver-qi extract of the present invention is a lot, has only provided a kind of method here, but is not limited to this kind method.
Medicine of the present invention, wherein dosage form comprises oral solid formulation and oral liquid, wherein oral solid formulation comprises: tablet, hard capsule, liquid type capsule, granule, soft capsule, drop pill, pill, pellet, slow releasing preparation; Oral liquid comprises: oral liquid, syrup, medicated wine; Granule wherein, oral liquid, hard capsule and additive of tablet are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate, mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, polyethylene compares pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more; Wherein the adjuvant of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C
5-C
14Triglyceride, in the ethyl oleate one or more, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
Pharmaceutical preparation of the present invention, wherein tablet specifically refers to common compressed tablet, coated tablet, coated tablet, Film coated tablets, enteric coated tablet, effervescent tablet, chewable tablet, multilayer tablet, dispersible tablet, Sublingual tablet, buccal tablet.
Pharmaceutical preparation of the present invention wherein can also contain aromatic and antiseptic, and wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
Pharmaceutical preparation of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, and the effect of promoting the circulation of QI to relieve pain cures mainly irritability stasis card, this prescription long-term clinical application demonstration, and to chronic hepatitis, chronic gastritis, cholecystitis etc. have better curative effect, and have application widely.
The bupleurum powder for relieving liver-qi method for preparing extractive is as follows:
Prescription: Radix Bupleuri 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Rhizoma Chuanxiong 4-6 part, Rhizoma Cyperi 4-6 part, Fructus Aurantii 4-6 part, Radix Paeoniae 4-6 part, Radix Glycyrrhizae Preparata 1-3 part
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and take by weighing each medical material of recipe quantity and add 6～20 times of water gagings and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, collection volatile oil; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying is that dry powder is that water extract is standby.
Preparation bupleurum powder for relieving liver-qi oral liquid and syrup
Bupleurum powder for relieving liver-qi extract and correctives, antiseptic and water are made oral liquid, and wherein correctives is selected from one or more in sucrose, saccharin sodium, sodium cyclamate, stevioside, aspartoyl aminotoluene acid methyl ester, the Oleum menthae (alcohol); Antiseptic is selected from sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more.
The preparation method of oral liquid and syrup is as follows: the bupleurum powder for relieving liver-qi extract adds water to be adjusted to preparation amount, adds correctives, antiseptic mix homogeneously, through technologies such as sterilization, fill, check, packings, promptly gets jichuan decoction oral liquid and syrup.
Wherein the weight percent content of Jia Ruing is: bupleurum powder for relieving liver-qi extract 5-80%, correctives 0.05-5%, antiseptic 0.001-2%, water 10-90%.
Preparation bupleurum powder for relieving liver-qi granule, pill, pellet, capsule, tablet
Granule, pill, pellet, capsule, and tablet are made the used adjuvant of concentrated granule or pill or tablet and are comprised diluent, binding agent, lubricant; Diluent is selected from one or more of starch, lactose, dextrin, microcrystalline Cellulose kind; Binding agent comprise water, macromolecular material and alcoholic acid one or more; Lubricant comprises one or more in magnesium stearate, Pulvis Talci, the stearic acid.
Granule, pill, pellet, capsule, and the preparation method of tablet as follows:
With bupleurum powder for relieving liver-qi extract and an amount of pharmaceutic adjuvant mixing, adding binding agent etc. is made soft material, makes granule with granulator, and dry, granulate promptly gets granule, or the general pill of making, or makes capsule through capsule filling machine, or makes tablet through tabletting.
Granule, pill, pellet, capsule, and tablet, wherein every gram granule is equivalent to contain the crude drug amount of 0.1-10 gram.
Preparation bupleurum powder for relieving liver-qi drop pill
The used adjuvant of preparation drop pill comprises substrate, liquid coolant.Substrate comprises one or more of Polyethylene Glycol, polyvidone, octadecanol, cholic acid apoplexy due to endogenous wind; Liquid coolant comprises one or more in water, dimethicone, vegetable oil, the liquid Paraffin.Get the substrate heating and melting, the bupleurum powder for relieving liver-qi extract is mixed wherein, splash in the suitable liquid coolant, drying is made, and wherein every gram drop pill is equivalent to contain the crude drug amount of 0.1-10 gram.。
Preparation bupleurum powder for relieving liver-qi soft capsule
With bupleurum powder for relieving liver-qi extract and adjuvant diluent, antioxidant, antiseptic, suspending agent, wherein diluent is selected from one or more in Polyethylene Glycol, propylene glycol, vegetable oil, the mineral oil; Antioxidant is selected from that glycine, vitamin E and derivant thereof, ascorbic acid, pyrosulfurous acid are received, in the potassium metabisulfite one or more; Antiseptic comprises sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more; Suspending agent is selected from one or more in chitin, cellulose family, agar, the Cera Flava.
Preparation method is as follows: bupleurum powder for relieving liver-qi extract 5-50%, add an amount of diluent, antioxidant, antiseptic, suspending agent mix homogeneously, prepared forms routinely, and wherein every gram soft capsule is equivalent to contain the crude drug amount of 0.1-10 gram.
Specific embodiment
Embodiment one: bupleurum powder for relieving liver-qi extract 1 (extractum and volatile oil) preparation method
Prescription: Radix Bupleuri 6g, Pericarpium Citri Reticulatae 6g, Rhizoma Chuanxiong 5g, Rhizoma Cyperi 5g, Fructus Aurantii 5g, Radix Paeoniae 5g, Radix Glycyrrhizae Preparata 3g
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 6～15 times of water gagings and soaks 2-10 hour, heat little boiling and extracts 2-3 time, and volatile oil is collected in the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and it is the about 8.5g of water extract that concentrating under reduced pressure gets extractum, the about 0.2g of volatile oil.
Embodiment two: bupleurum powder for relieving liver-qi extract 2 (dry powder and volatile oil) preparation method
Prescription: Radix Bupleuri 6g, Pericarpium Citri Reticulatae 6g, Rhizoma Chuanxiong 4.5g, Rhizoma Cyperi 4.5g, Fructus Aurantii 4.5g, Radix Paeoniae 4.5g, Radix Glycyrrhizae Preparata 1.5g
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 8～10 times of water gagings and soaks 2-8 hour, and being heated to boils extracts 2-3 time, and volatile oil is collected in the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure, and it is the about 6.0g of water extract that spray drying gets dry powder; The about 0.15g of volatile oil.
Embodiment three: bupleurum powder for relieving liver-qi oral solid formulation preparation method
(1) preparation bupleurum powder for relieving liver-qi granule
Prescription:
Bupleurum powder for relieving liver-qi extract 1 10-90%
Starch 5.0-70%
Dextrin 2.0-20%
Xylitol 5.0-20%
Sorbic acid methyl ester 0.001-2.0%
Optimizing prescriptions:
Bupleurum powder for relieving liver-qi extract 1 8.5g
Starch 3.0g
Dextrin 3.0g
Xylitol 2.0g
Sorbic acid methyl ester 0.002g
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment one, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and packing is made two bags, every bag of 8.25g.
(2) preparation bupleurum powder for relieving liver-qi tablet:
(1) ordinary tablet prescription:
Bupleurum powder for relieving liver-qi extract 2 5.0-90%
Starch 5.0-50%
Dextrin 2.0-20%
Microcrystalline Cellulose 5.0-20%
Pulvis Talci 0.5-5.0%
Magnesium stearate 0.1-5.0%
Optimizing prescriptions:
Bupleurum powder for relieving liver-qi extract 2 6.0g
Starch 4g
Dextrin 3g
Microcrystalline Cellulose 2g
Pulvis Talci 0.2g
Magnesium stearate 0.1g
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(2) effervescent tablet is write out a prescription and is prepared as follows:
Prescription: bupleurum powder for relieving liver-qi extract 2 6.0
Starch 2g
Dextrin 2g
Microcrystalline Cellulose 1g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Anhydrous citric acid 1.0g
Sodium bicarbonate 1.0g
Lactose 0.5g
Water is an amount of
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(3) buccal tablet is write out a prescription and is prepared as follows:
Prescription: bupleurum powder for relieving liver-qi extract 2 6g
Starch 2g
Dextrin 3g
Microcrystalline Cellulose 1g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Citric acid 0.1g
Aspartame 0.02g
Water is an amount of
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and tabletting is promptly.
(4) coated tablet is write out a prescription and is prepared as follows:
Prescription: bupleurum powder for relieving liver-qi extract 2 6g
Starch 3g
Dextrin 2g
Microcrystalline Cellulose 2g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, the an amount of dissolve with ethanol of volatile oil, evenly be sprayed on the granule, cold drying, tabletting is made coating material according to conventional method, with coating machine coating promptly, the difference according to coating material can be bundled into sugar-coat and film-coat.
(3) preparation bupleurum powder for relieving liver-qi drop pill
Prescription:
Bupleurum powder for relieving liver-qi extract 2 10-70%
Macrogol 4000 20-80%
Polyethylene glycol 6000 20.0-50%
Liquid paraffin is an amount of
Optimizing prescriptions:
Bupleurum powder for relieving liver-qi extract 2 6g
Macrogol 4000 6g
Polyethylene glycol 6000 6g
Liquid paraffin is an amount of
Method for making: Macrogol 4000 and the polyethylene glycol 6000 ratio in 1: 1 is added in the lead pan of drop pill machine, in oil bath, be heated to 90-100 ℃, treat whole fusions after, add and to prepare bupleurum powder for relieving liver-qi extract 2 by the method among the embodiment two, be stirred to fusion, be transferred in the reservoir, airtight and the insulation at 80-90 ℃, regulator solution titer valve, splash in 10-15 ℃ the liquid paraffin, fish for the drop pill drop to the greatest extent and wipe liquid Paraffin, put in the Calx cylinder dry, both.
(4) preparation bupleurum powder for relieving liver-qi pill
Prescription:
Bupleurum powder for relieving liver-qi extract 2 6g
Starch 3g
Magnesium stearate 0.1g
Dextrin 3g
Water is an amount of
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, cold drying, and pelleting is promptly.
(5) preparation bupleurum powder for relieving liver-qi soft capsule
The content prescription:
Bupleurum powder for relieving liver-qi extract 2 6g
Vegetable oil 10g
Ethylparaben 0.01g
Cera Flava 2g
Method for making: prepare the bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add vegetable oil, the Cera Flava of optimizing prescriptions percentage amounts, ethylparaben prepared routinely forms.
(6) preparation bupleurum powder for relieving liver-qi capsule
Prescription:
Bupleurum powder for relieving liver-qi extract 2 10-95%
Starch 5-55%
Magnesium stearate 0.1-5%
Optimizing prescriptions:
Bupleurum powder for relieving liver-qi extract 2 6g
Starch 5g
Magnesium stearate 0.5g
Method for making: prepare bavin bupleurum powder for relieving liver-qi extract by the method among the embodiment two, add the recipe quantity adjuvant and make granule according to a conventional method, an amount of dissolve with ethanol of volatile oil evenly is sprayed on the granule, and cold drying, fill are promptly.
Embodiment four: bupleurum powder for relieving liver-qi oral liquid preparation method
(1) oral liquid preparation
Prescription: bupleurum powder for relieving liver-qi extract 1 5-80%
Sucrose 5.0-50%
Sodium cyclamate 5.0-40%
Sorbic acid methyl ester 0.001-2%
Distilled water 10-90%.
Optimizing prescriptions:
Bupleurum powder for relieving liver-qi extract 1 8.5g
Sucrose 1.0g
Sodium cyclamate 0.5g
Sorbic acid methyl ester 0.002g
Distilled water is settled to 20ml.
Method for making: prepare the bupleurum powder for relieving liver-qi extract by the method among the embodiment one, add each adjuvant of prescription and distilled water, again through the ultrafilter ultrafiltration, the ultrafiltrate fill, sterilization, promptly.
Claims (7)
- One kind by 7 flavor Chinese medicines preparations such as Radix Bupleuri cure mainly bupleurum powder for relieving liver-qi drug oral preparation of irritability stasis and preparation method thereof, mixed extract (extractum or dry powder and volatile oil) with Radix Bupleuri, Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, Rhizoma Cyperi, Fructus Aurantii, Radix Paeoniae, Radix Glycyrrhizae Preparata is a raw material, with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, wherein:1.1 each flavour of a drug and shared percentage by weight (unit is g or kg) are in the prescription: Radix Bupleuri 2-10 part, Pericarpium Citri Reticulatae 2-10 part, Rhizoma Chuanxiong 2-8 part, Rhizoma Cyperi 2-8 part, Fructus Aurantii 2-8 part, Radix Paeoniae 2-8 part, Radix Glycyrrhizae Preparata 1-6 partEach flavour of a drug and weight fraction are in the best optimizing prescriptions:Radix Bupleuri 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Rhizoma Chuanxiong 4-6 part, Rhizoma Cyperi 4-6 part, Fructus Aurantii 4-6 part, Radix Paeoniae 4-6 part, Radix Glycyrrhizae Preparata 1-3 part;1.2 substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;1.3 proportioning: extract (comprise water extract: extractum or dry powder and volatile oil): substrate=9: 1～1: 9.
- 2. according to the bupleurum powder for relieving liver-qi extract in the claim 1, its preparation technology is as follows:1.1 each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges, and collects volatile oil;1.2 aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;1.3 bupleurum powder for relieving liver-qi water extract and volatile oil and carrier pharmaceutically or adjuvant root make up routinely technology and make various oral administration solids or liquid preparation, these wherein used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
- 3. according to the bupleurum powder for relieving liver-qi oral drug preparation among the claim 1-2, wherein dosage form comprises tablet, hard capsule, granule, soft capsule, liquid type capsule, drop pill and oral liquid, wherein:1.1 granule, tablet, hard capsule and oral liquid liquid preparation substrate are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts (mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate), mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more.1.2 the substrate of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C 5-C 14Triglyceride, in the ethyl oleate one or more.
- 4. according to the pharmaceutical preparation among the claim 1-4, wherein tablet specifically refers to common compressed tablet, coated tablet, coated tablet, Film coated tablets, enteric coated tablet, effervescent tablet, chewable tablet, multilayer tablet, dispersible tablet, Sublingual tablet, buccal tablet.
- 5. according to the pharmaceutical preparation among the claim 1-3, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
- 6. according to the pharmaceutical preparation among the claim 1-5, wherein can also contain aromatic and antiseptic, wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
- 7. according to the bupleurum powder for relieving liver-qi drug oral preparation among the claim 1-6, said preparation has dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of promoting the circulation of QI to relieve pain, cure mainly irritability stasis card, this prescription long-term clinical application shows, to chronic hepatitis, chronic gastritis, cholecystitis etc. have better curative effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810007841XA CN101229304A (en) | 2008-02-25 | 2008-02-25 | Chinese thorowax Shugansan oral preparation and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810007841XA CN101229304A (en) | 2008-02-25 | 2008-02-25 | Chinese thorowax Shugansan oral preparation and preparing method thereof |
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| CN101229304A true CN101229304A (en) | 2008-07-30 |
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| CNA200810007841XA Pending CN101229304A (en) | 2008-02-25 | 2008-02-25 | Chinese thorowax Shugansan oral preparation and preparing method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991809B (en) * | 2009-08-13 | 2012-06-27 | 马文才 | Traditional Chinese medicinal composition for treating liver stagnation |
| CN102670962A (en) * | 2012-05-16 | 2012-09-19 | 李承平 | Combined tablet capable of soothing liver and relieving depression |
| CN103495061A (en) * | 2013-09-25 | 2014-01-08 | 周志坚 | Traditional Chinese medicine composition for treating cholecystitis caused by stagnation of liver qi and phlegm and blood stasis |
| CN104721455A (en) * | 2015-04-10 | 2015-06-24 | 王红垒 | Traditional Chinese medicine for treating acute cholecystitis |
| CN104771514A (en) * | 2015-04-22 | 2015-07-15 | 王玉玲 | Stagnated liver qi dispersing and bile flow promoting medicament for treating cholecystitis and preparation method thereof |
| CN105832785A (en) * | 2015-01-15 | 2016-08-10 | 邓学峰 | Pharmaceutical composition containing radix bupleuri extract and preparation thereof |
| CN106822522A (en) * | 2017-03-17 | 2017-06-13 | 哈尔滨中科生物工程有限公司 | A kind of preparation method and application for improving poultry growth performance and immunity herb fermenting preparation |
| CN108030850A (en) * | 2018-01-29 | 2018-05-15 | 湘潭大学 | A kind of supercritical CO2The method for extracting active ingredient in bupleurum powder for relieving liver-qi |
| CN108159352A (en) * | 2018-02-06 | 2018-06-15 | 赵子荣 | A kind of drug of soothing liver-qi stagnation |
| CN110237166A (en) * | 2019-04-25 | 2019-09-17 | 华中科技大学鄂州工业技术研究院 | A kind of natural composition and preparation method thereof improving liver function and pre- preventing bone rarefaction |
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2008
- 2008-02-25 CN CNA200810007841XA patent/CN101229304A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991809B (en) * | 2009-08-13 | 2012-06-27 | 马文才 | Traditional Chinese medicinal composition for treating liver stagnation |
| CN102670962A (en) * | 2012-05-16 | 2012-09-19 | 李承平 | Combined tablet capable of soothing liver and relieving depression |
| CN103495061A (en) * | 2013-09-25 | 2014-01-08 | 周志坚 | Traditional Chinese medicine composition for treating cholecystitis caused by stagnation of liver qi and phlegm and blood stasis |
| CN103495061B (en) * | 2013-09-25 | 2015-01-07 | 周志坚 | Traditional Chinese medicine composition for treating cholecystitis caused by stagnation of liver qi and phlegm and blood stasis |
| CN105832785A (en) * | 2015-01-15 | 2016-08-10 | 邓学峰 | Pharmaceutical composition containing radix bupleuri extract and preparation thereof |
| CN104721455A (en) * | 2015-04-10 | 2015-06-24 | 王红垒 | Traditional Chinese medicine for treating acute cholecystitis |
| CN104771514A (en) * | 2015-04-22 | 2015-07-15 | 王玉玲 | Stagnated liver qi dispersing and bile flow promoting medicament for treating cholecystitis and preparation method thereof |
| CN106822522A (en) * | 2017-03-17 | 2017-06-13 | 哈尔滨中科生物工程有限公司 | A kind of preparation method and application for improving poultry growth performance and immunity herb fermenting preparation |
| CN108030850A (en) * | 2018-01-29 | 2018-05-15 | 湘潭大学 | A kind of supercritical CO2The method for extracting active ingredient in bupleurum powder for relieving liver-qi |
| CN108159352A (en) * | 2018-02-06 | 2018-06-15 | 赵子荣 | A kind of drug of soothing liver-qi stagnation |
| CN110237166A (en) * | 2019-04-25 | 2019-09-17 | 华中科技大学鄂州工业技术研究院 | A kind of natural composition and preparation method thereof improving liver function and pre- preventing bone rarefaction |
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