CN104771514A - Stagnated liver qi dispersing and bile flow promoting medicament for treating cholecystitis and preparation method thereof - Google Patents
Stagnated liver qi dispersing and bile flow promoting medicament for treating cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a stagnated liver qi dispersing and bile flow promoting medicament for treating cholecystitis. The stagnated liver qi dispersing and bile flow promoting medicament is prepared from the following main raw medicinal materials in parts by mass: 10-13 parts of ligusticum wallichii, 8-13 parts of jasmine roots, 10-15 parts of endive, 12-18 parts of aculeate staff-tree, 11-15 parts of snow of june herb, 13-15 parts of herba andrographitis, 11-13 parts of dracocephalum tanguticum maxim, 7-15 parts of negundo chastetree fruit, 13-18 parts of Dried tangerine peel, 9-16 parts of Swertia punicea Hemsl., 12-17 parts of capillary artemisia, 9-12 parts of lushan mountain barberry, 14-18 parts of honeysuckle, 12-14 parts of neat philippine violet herb and 9-13 parts of fructus aurantii. The stagnated liver qi dispersing and bile flow promoting medicament is prepared based on years of clinical practice, has the effects of clearing away heat, removing toxicity, dispersing stagnated liver qi and promoting bile flow and a remarkable curative effect and treats both manifestation and root cause of the cholecystitis.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament and method for making for the treatment of cholecystitis.
Background technology
The infection of cholecystitis system, bile stimulation, pancreatic juice are to biliary tract reflux, and the gallbladder inflammatory diseases that the red alpine rush or palm-bark rain cape of gallbladder and lipoids Metabolic disorder etc. are caused.Cholecystitis can be divided into acute cholecystitis and chronic cholecystitis again.The typical performance of acute cholecystitis is that the upper right abdomen of acute attack continues or paroxysmal colic, can radiate, gallbladder area tenderness or rebound tenderness, muscle tonus, heating, nausea and vomiting, or have jaundice and blood leukocytes to increase to right corner; And chronic cholecystitis shows as recurrent exerbation and the abdominal distention that weight differs, the indigestion symptoms such as upper right abdomen and epigastric discomfort or pain, be often radiated to the right shoulder back of the body, companion's belch pantothenic acid, enter the aggravation of greasy food symptom.It is the one of biliary system infective inflammation.
Publication No. CN 104189577 A(application number 201410425079.2) Chinese patent literature disclose a kind of Chinese medicine being used for the treatment of cholecystitis, it is prepared from by the raw medicinal material of following weight proportion: Fructus Toosendan 7 parts, Herba Lysimachiae 35 parts, Herba Artemisiae Scopariae 12 parts, Caulis Bambusae In Taenia 8 parts, Fructus Ligustri Lucidi 10 parts, Herba Cistanches 15 parts.Publication No. CN 102872362 A(application number 201210408458.1) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic cholecystitis, this Chinese medicine is made up of Radix Mume, Stigma Maydis, Herba Rabdosiae Lophanthoidis, Radix Cynanchi Paniculati, Herba Gentianopsis Paludosae, Herba menyanthis, Herba Patriniae, Os Draconis, Fructus Citri tangerinae core, Radix Stephaniae Cepharanthae, Pericarpium Vignae sinensis, Radix Gentianae Macrophyllae.Publication No. CN 103157069 A(application number 201310115773.X) Chinese patent literature disclose a kind of Miao Ethnomedicine for the treatment of cholecystitis, the quality of medicinal material proportioning of this Miao Ethnomedicine is as follows: Rhizoma Coptidis 10 ~ 15, Herba Artemisiae Scopariae 7 ~ 10, Herba Dichodrae 15 ~ 20, Radix Curcumae 5 ~ 8, Fructus Evodiae 5 ~ 8.Method for making is: get Rhizoma Coptidis, Herba Artemisiae Scopariae, Herba Dichodrae, Radix Curcumae, Fructus Evodiae 5 taste medical material clean respectively, with hot-air seasoning, then use disinfection by ultraviolet light, then grind to form 60 order powder respectively; Mix according to the quality proportioning of formula, incapsulate after mix homogeneously, every 1g, obtains patent medicine for subsequent use.
Though operative treatment can remove focus fast, the suitability is wide, injury is comparatively large, and treatment by Chinese herbs to have side effect little, the advantage that anti-recurrence rate is effective, part Chinese medicine formula Clinical Practice, therapeutic effect is poor, therefore needs to work out the more significant formula of curative effect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take wide a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament and the method for making for the treatment of cholecystitis of safe and applicable.
Technical scheme of the present invention is:
Treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Chuanxiong 10-13; Radix Fructus Gardeniae 8-13; Herba Cichorii 10-15; Celastrus aceleatus Merr 12-18; Serissa foetida 11-15; Herba Andrographis 13-15; Herba Dracocephali tangutici 11-13; Fructus Viticis Negundo 7-15; Pericarpium Citri Reticulatae 13-18; Herba Swertiae Puniceae 9-16; Herba Artemisiae Scopariae 12-17; Caulis seu radix berberidis virgetori 9-12; Flos Lonicerae 14-18; Herba Violae mundae 12-14; Fructus Aurantii 9-13.
Preferred version is, Rhizoma Chuanxiong 11-12; Radix Fructus Gardeniae 9-12; Herba Cichorii 11-14; Celastrus aceleatus Merr 14-16; Serissa foetida 12-14; Herba Andrographis 13.5-14.5; Herba Dracocephali tangutici 11.5-12.5; Fructus Viticis Negundo 9-13; Pericarpium Citri Reticulatae 14-17; Herba Swertiae Puniceae 11-14; Herba Artemisiae Scopariae 13-16; Caulis seu radix berberidis virgetori 10-11; Flos Lonicerae 15-17; Herba Violae mundae 12.5-13.5; Fructus Aurantii 10-12.
Be more preferably, Rhizoma Chuanxiong 11.5; Radix Fructus Gardeniae 10.5; Herba Cichorii 12.5; Celastrus aceleatus Merr 15; Serissa foetida 13; Herba Andrographis 14; Herba Dracocephali tangutici 12; Fructus Viticis Negundo 11; Pericarpium Citri Reticulatae 15.5; Herba Swertiae Puniceae 12.5; Herba Artemisiae Scopariae 14.5; Caulis seu radix berberidis virgetori 10.5; Flos Lonicerae 16; Herba Violae mundae 13; Fructus Aurantii 11.
Described a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, add yellow wine and soak 15-25 minute (preferred: to soak 20 minutes), slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, be added in step (4) gained filtrate, stir, obtain decoction.
Described a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament decoction of cholecystitis, the amount that step (1) adds yellow wine is the 0.4-0.6 of crude drug quality doubly (preferred: the amount adding yellow wine is 0.5 times of crude drug quality).
Described a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 15-25 minute (preferred: soak 20 minutes), and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, spraying dry, obtains dry thing;
(5) step (1) (2) (4) made crude drug and dry thing are pulverized and sieved, namely subpackage obtains powder.
Described a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament powder of cholecystitis, it is (preferred: to pulverize 140-200 mesh sieve that step (5) pulverized 100-240 mesh sieve; Be more preferably: pulverized 170 mesh sieves).
Described a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 15-25 minute (preferred: soak 20 minutes), and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, heating is concentrated into thick paste;
(5) made to step (1) (2) crude drug is pulverized, be added in step (4) gained thick paste, dry, be ground into end, be packed in capsule, obtain capsule.
Described a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting drug capsule agent of cholecystitis, the every capsules Chinese medicine powder content of step (5) is that 0.5-0.7g(is preferred: every capsules Chinese medicine powder content is 0.6g).
Described a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 15-25 minute (preferred: soak 20 minutes), and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, heating is concentrated into thick paste;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained thick paste, dry, pulverize, add adjuvant, round sheet dosage form made by tabletting.
Described a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament tablet of cholecystitis, the metering of step (5) tablet is that 0.3-0.6g/ grain is (preferred: the metering of tablet is 0.4-0.5g/ grain; Be more preferably: the metering of tablet is 0.45g/ grain).
A kind of depressed liver-energy dispersing and function of gallbladder promoting reagent combination science for the treatment of cholecystitis provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, this formula meets Chinese medical theory, has effect of heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting;
2, Chinese crude drug selected by the present invention, safety has no side effect, can long-term taking, and the suitability is wider;
3, products obtained therefrom of the present invention can keep the comprehensive therapeutic effect of each composition of crude drug, and cure rate is high, Be very effective.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Chuanxiong 10 parts, Radix Fructus Gardeniae 8 parts, Herba Cichorii 10 parts, Celastrus aceleatus Merr 12 parts, Serissa foetida 11 parts, Herba Andrographis 13 parts, Herba Dracocephali tangutici 11 parts, Fructus Viticis Negundo 7 parts, Pericarpium Citri Reticulatae 13 parts, 9 parts, Herba Swertiae Puniceae, Herba Artemisiae Scopariae 12 parts, Caulis seu radix berberidis virgetori 9 parts, Flos Lonicerae 14 parts, Herba Violae mundae 12 parts, Fructus Aurantii 9 parts.Above-mentioned a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament decoction of cholecystitis is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 20 minutes, and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water and steam 25 minutes, take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve removes crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add the water soaking 15 minutes of boiled crude drug quality 6.5 times, big fire is heated to boiling, add Flos Lonicerae and Herba Artemisiae Scopariae again, turn little fire and decoct 25 minutes, filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, be added in step (4) gained filtrate, stir, obtain decoction.
embodiment 2treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Chuanxiong 13 parts, Radix Fructus Gardeniae 13 parts, Herba Cichorii 15 parts, Celastrus aceleatus Merr 18 parts, Serissa foetida 15 parts, Herba Andrographis 15 parts, Herba Dracocephali tangutici 13 parts, Fructus Viticis Negundo 15 parts, Pericarpium Citri Reticulatae 18 parts, 16 parts, Herba Swertiae Puniceae, Herba Artemisiae Scopariae 17 parts, Caulis seu radix berberidis virgetori 12 parts, Flos Lonicerae 18 parts, Herba Violae mundae 14 parts, Fructus Aurantii 13 parts.Above-mentioned a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament powder of cholecystitis is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 20 minutes, and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water and steam 25 minutes, take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve removes crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add the water soaking 15 minutes of boiled crude drug quality 6.5 times, big fire is heated to boiling, add Flos Lonicerae and Herba Artemisiae Scopariae again, turn little fire and decoct 25 minutes, filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, spraying dry, obtains dry thing;
(5) step (1) (2) (4) made crude drug and dry thing were pulverized 170 mesh sieves, namely subpackage obtains powder.
Model case: xxx, women, 41 years old.Main suit: epigastrium distending pain, with vomiting.Medical history: eat cake when patient celebrates a birthday too much, cause epigastrium distending pain, with Nausea and vomiting symptom, tell the rear state of an illness and do not alleviate, to examination in hospital, upper right abdominal pressure pain, without rebound tenderness, B ultrasonic display gallbladder increases, thickening of capsule wall of gallbladder, quantity of leucocyte 17.1 × 10
9/ L, is diagnosed as acute cholecystitis.
Take this example gained powder, each 3-5g, warm boiled water, one day twice ten days is a course for the treatment of, after patient takes two courses for the treatment of, symptom obviously alleviates, through check, gallbladder volume form is normal, and quantity of leucocyte drops to normally, after continuing to strengthen a course for the treatment of, patient fully recovers, and follows up a case by regular visits in two years, does not recur.
embodiment 3treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Chuanxiong 11 parts, Radix Fructus Gardeniae 9 parts, Herba Cichorii 11 parts, Celastrus aceleatus Merr 14 parts, Serissa foetida 12 parts, Herba Andrographis 13.5 parts, Herba Dracocephali tangutici 11.5 parts, Fructus Viticis Negundo 9 parts, Pericarpium Citri Reticulatae 14 parts, 11 parts, Herba Swertiae Puniceae, Herba Artemisiae Scopariae 13 parts, Caulis seu radix berberidis virgetori 10 parts, Flos Lonicerae 15 parts, Herba Violae mundae 12.5 parts, Fructus Aurantii 10 parts.Above-mentioned a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting drug capsule agent of cholecystitis is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 20 minutes, and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water and steam 25 minutes, take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve removes crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add the water soaking 15 minutes of boiled crude drug quality 6.5 times, big fire is heated to boiling, add Flos Lonicerae and Herba Artemisiae Scopariae again, turn little fire and decoct 25 minutes, filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, heating is concentrated into thick paste;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained thick paste, dry, be ground into end, be packed in capsule, every capsules Chinese medicine powder content is 0.6g, obtains capsule.
Model case: xxx, male, 52 years old.Medical history: patient's epigastrium angor one month, with poor appetite, feel sick, slightly greasy, the state of an illness just increases the weight of, through having a medical check-up, abdominal tenderness is obvious, bowel sounds active, B ultrasonic display cholelithiasis (0.6*0.8cm), gallbladder wall is crude rough, and shrink of capsular space is diagnosed as chronic cholecystitis.
Recommend to take this example gained capsule, each 2-3 grain, warm boiled water through people, one day twice, within ten days, be a course for the treatment of, patient takes a course for the treatment of, colic symptoms is alleviated to some extent, and appetite recovers normal, after taking two courses for the treatment of, check cholelithiasis disappears, gallbladder wall recovers smooth, and adhere to again taking two courses for the treatment of, uncomfortable disease is all eliminated, recovery from illness, without other untoward reaction.
embodiment 4treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Chuanxiong 12 parts, Radix Fructus Gardeniae 12 parts, Herba Cichorii 14 parts, Celastrus aceleatus Merr 16 parts, Serissa foetida 14 parts, Herba Andrographis 14.5 parts, Herba Dracocephali tangutici 12.5 parts, Fructus Viticis Negundo 13 parts, Pericarpium Citri Reticulatae 17 parts, 14 parts, Herba Swertiae Puniceae, Herba Artemisiae Scopariae 16 parts, Caulis seu radix berberidis virgetori 11 parts, Flos Lonicerae 17 parts, Herba Violae mundae 13.5 parts, Fructus Aurantii 12 parts.Above-mentioned a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament tablet of cholecystitis is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 20 minutes, and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water and steam 25 minutes, take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve removes crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add the water soaking 15 minutes of boiled crude drug quality 6.5 times, big fire is heated to boiling, add Flos Lonicerae and Herba Artemisiae Scopariae again, turn little fire and decoct 25 minutes, filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, heating is concentrated into thick paste;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained thick paste, dry, pulverize, add adjuvant, according to the metering of 0.45g/ grain, round sheet dosage form made by tabletting.
Model case: xxx, male, 36 years old.Medical history: patient's obese, likes eating rich food dish, within the next few days abdominal pain, and distension is uncomfortable, and with feeling sick, inappetence, the symptom such as nervous, abdomen examination display upper right abdomen is full, and have obvious tenderness and rebound tenderness, last diagnostic is acute cholecystitis.
Patient refuses operation, adopts traditional Chinese medical science expectant treatment, takes this example gained tablet, each 3-4 sheet, warm boiled water, one day twice, it within ten days, is a course for the treatment of, after patient takes one week, the symptoms such as stomachache, Nausea and vomiting alleviate, after continuing to take a course for the treatment of, uncomfortable disease disappears substantially, further consultation checks, indices all recovers normal, and patient fully recovers.
embodiment 5treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Chuanxiong 11.5 parts, Radix Fructus Gardeniae 10.5 parts, Herba Cichorii 12.5 parts, Celastrus aceleatus Merr 15 parts, Serissa foetida 13 parts, Herba Andrographis 14 parts, Herba Dracocephali tangutici 12 parts, Fructus Viticis Negundo 11 parts, Pericarpium Citri Reticulatae 15.5 parts, 12.5 parts, Herba Swertiae Puniceae, Herba Artemisiae Scopariae 14.5 parts, Caulis seu radix berberidis virgetori 10.5 parts, Flos Lonicerae 16 parts, Herba Violae mundae 13 parts, Fructus Aurantii 11 parts.Above-mentioned a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament decoction of cholecystitis is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 20 minutes, and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water and steam 25 minutes, take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve removes crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add the water soaking 15 minutes of boiled crude drug quality 6.5 times, big fire is heated to boiling, add Flos Lonicerae and Herba Artemisiae Scopariae again, turn little fire and decoct 25 minutes, filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, be added in step (4) gained filtrate, stir, obtain decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Chuanxiong: nature and flavor with return through: pungent, temperature.Return liver, gallbladder, pericardium channel.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.For obstruction of qi in the chest and cardialgia, the twinge of the breast side of body, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea, abdominal mass abdominal mass is suffered from abdominal pain, headache, rheumatic arthralgia.
Radix Fructus Gardeniae: base is former: be the root of Rubiaceae Gardenia Ellis plant Fructus Gardeniae.The property of medicine: sweet in the mouth, hardship, cold in nature.Function cures mainly: clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.Cure mainly jaundice, dysentery, the high heat of flu, spits blood, stranguria, edema, acute mastitis, acute toothache, sore and toxic, traumatic injury.
Herba Cichorii: base is former: be the aerial parts of feverfew Herba Cichorii.Chemical analysis: herb contains aesculetin, aesculin, 6,7-dihydroxycoumarin-7-glucoside., lactucin and lactucopicin.Leaf is containing caftaric acid, and chicoric acid has another name called chicoric acid.Nature and flavor: bitter in the mouth; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main jaundice due to damp-heat; Oedema due to nephritis; Epigastric distending pain; Inappetence.
Celastrus aceleatus Merr: base is former: be the root of Celastraceae plant Celastrus aceleatus Merr.Chemical analysis: containing dulcitol and cupreol.Nature and flavor: bitter; Pungent; Cool.Gui Jing: liver; Gallbladder; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main air pain of dampness syndrome; Gout; Nephritis; Cholecystitis; Leukemia.
Serissa foetida: base is former: be Rubiaceae Serissa foetida platymiscium Serissa foetida, be used as medicine with Herb.Nature and flavor: light, micro-pungent, cool.Function cures mainly: dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.For flu, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension complicated headache, migraine, rheumatic arthralgia, leucorrhea; Stem ashing eye dripping controls mist.
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.Nature and flavor: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." return through: " Quanzhou book on Chinese herbal medicine ": " enters the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.Pharmacological action: 1. antibacterial action 2. antivirus action 3. other effects.
Herba Dracocephali tangutici: base is former: be the whole herb with root of labiate tangut dragonhead.Chemical analysis: herb contains oleanolic acid, ursolic acid, daucosterol, skimmin, cosmosiin, sesamin, sesame glycoside and sesame glycoside-6 '-acetas etc.Nature and flavor: acrid in the mouth; Bitter; Cold in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Preventing phlegm from forming and stopping coughing.Main icterohepatitis; Gastritis; Gastric ulcer; Tracheitis.
Fructus Viticis Negundo: base is former: be the fruit of Verbenaceae five-leaved chaste tree.Chemical analysis: Fructus Viticis Negundo dry product, containing quintessence oil 0.1%, contains 1, 8-Cineole, l-sabinene, l-2-pinene, camphene, caryophyllene and Diterpenes, sesquiterpenoid and azulenoid etc. in oil.Still containing flavonoid and cardiotonic glycoside.Nature and flavor: arduous, temperature.Function cures mainly: dispel the wind, expectorant, circulation of qi promoting, pain relieving.Cure cold, cough, asthma, migratory arthralgia, malaria, stomachache, hernia, anal fistula.
Pericarpium Citri Reticulatae: nature and flavor with return through: bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Herba Swertiae Puniceae: base is former: be the herb of gentianaceae plant Swertia punicea Hemsl..Nature and flavor: bitter; Cold in nature.Function cures mainly: liver heat removing function of gallbladder promoting; Heat-clearing and toxic substances removing; Dampness removing.Main acute icterohepatitis; Cholecystitis; Anemopyretic cold; Acute toothache; Laryngopharynx swelling and pain; Dyspepsia; Acute bacillary dysentery; Urinary system infection; Hiccough and deaf; Burn and scald.
Herba Artemisiae Scopariae: base is former: be the seedling of feverfew Herba Artemisiae Scopariae.Chemical analysis: containing 6,7-Dimethylesculetin and volatile oil, is mainly a-pinene, capillin, capillen block, capillanol, capillarisin, chlorogenic acid etc. in oil.Nature and flavor: cold nature, acrid in the mouth, hardship.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.
Caulis seu radix berberidis virgetori: base is former: be stem and the root of Berberidaceae plant Mount Lushan Radix Berberidis Amurensis.Chemical analysis: Mount Lushan Radix Berberidis Amurensis stem is containing berberine 2.84%, and berbamine 1.98%, also containing jateorhizine, isotetrandrine root bark is containing berberine 4.72%.Congener long column Radix Berberidis Amurensis also contains berbamine etc. containing berberine 4.99%.Nature and flavor: bitter; Cold in nature.Gui Jing: liver; Stomach; Large intestine channel.Function cures mainly: clearing away damp-heat; Removing toxic substances.Main damp-heat dysentery; Jaundice; Cholecystitis; Aphtha; Laryngopharynx swelling and pain, acute catarrhal conjunctivitis conjunctival congestion; Damp and hot stranguria with turbid discharge; Erysipelas; Sore swollen toxin; Burn and scald.
Flos Lonicerae: sweet in the mouth, micro-hardship, cold nature.Have heat-clearing and toxic substances removing, expelling pathogenic factors from the exterior is gone out, effect of stomach function regulating preventing or arresting vomiting, stops up resistance, disorder of stomach-QI, fever and irritability for pathogenic heat.
Herba Violae mundae: base is former: be the herb of Violaceae plant Herba Violae mundae.Nature and flavor: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold nature, acrid in the mouth acid." return through: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters liver, walks sun bright." function cures mainly: loose wind, and heat clearing away is soothing the liver, detumescence.Control wind-fire acute conjunctivitis, corneal nebula hides eyeball, acute mastitis, scrofula, and furuncle swells.
Fructus Aurantii: base is former: be the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..Nature and flavor with return through: bitter, pungent, sour, be slightly cold.Return spleen, stomach warp.There is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention, visceroptosis.
test example 1a kind of clinical practice for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament (embodiment 5) of cholecystitis of gained of the present invention:
Choose crowd: in January ,-2015 in March, 2014, according to medical case history, five hospitals screening acute cholecystitis patients 210 examples, male 112 example, women 98 example, age 21-66 year, average 38.9 ± 1.6 years old, course of disease 1-5 days; Chronic cholecystitis patient 190 example, male 98 example, women 92 example, age 20-65 year, average 40.8 ± 1.2 years old, course of disease 1-8.
Before test, patient is divided into two groups at random, experimental group 224 example and matched group 176 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, and each 100-200ml(changes to some extent according to situation), one day twice, warmly taking, ten days is a course for the treatment of; Matched group takes other conventional medicines (XIAOYAN LIDAN PIAN, JINDAN PIAN, DANSHU JIAONANG or liver heat removing choleretic granules etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Test grouping situation is as shown in table 1:
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: clinical symptoms and sign disappear, and the indexs such as leukocyte recover normal, and ultrasound diagnosis gallbladder recovers normal; (2) effective: clinical symptoms and sign disappear, and the indexs such as leukocyte are normal, B ultrasonic display gallbladder obviously improves; (3) effective: clinical symptoms and sign major part disappear, and the treatment such as leukocyte declines, B ultrasonic display gallbladder makes moderate progress; (4) invalid: before and after treatment, symptom and sign are not all improved.
Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 2:
As shown in Table 2, the healing patient of experimental group is 129 examples, and cure rate is 57.6%, effective patient is 52 examples, and obvious effective rate is 23.2%, and effective patient is 35 examples, effective percentage is 15.6%, and total effective rate is 96.4%, and the patient that matched group is cured is 77 examples, cure rate is 43.8%, and effective patient is 28 examples, and obvious effective rate is 15.9%, effective patient is 35 examples, and effective percentage is 19.9%, total effective rate 79.6%, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The Chinese medicine used in the present invention, multiple medical material synergism, Rhizoma Chuanxiong can wind-expelling pain-stopping, Radix Fructus Gardeniae, Serissa foetida, Herba Dracocephali tangutici can clearing away heat-damp and promoting diuresis, and Herba Cichorii, Caulis seu radix berberidis virgetori, Flos Lonicerae can heat-clearing and toxic substances removing, and Celastrus aceleatus Merr can expelling wind and removing dampness, Herba Andrographis can be subsided a swelling by removing heat from blood, Fructus Viticis Negundo can promoting the circulation of QI to relieve pain, and Pericarpium Citri Reticulatae can regulating qi-flowing for strengthening spleen, and Herba Swertiae Puniceae can liver heat removing function of gallbladder promoting, Herba Artemisiae Scopariae can wet clearly and bring down a fever, Herba Violae mundae can soothing the liverly be subsided a swelling, and the feasible stagnant relieving distension of Fructus Aurantii, plays effect of heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a depressed liver-energy dispersing and function of gallbladder promoting medicament for cholecystitis, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Chuanxiong 10-13; Radix Fructus Gardeniae 8-13; Herba Cichorii 10-15; Celastrus aceleatus Merr 12-18; Serissa foetida 11-15; Herba Andrographis 13-15; Herba Dracocephali tangutici 11-13; Fructus Viticis Negundo 7-15; Pericarpium Citri Reticulatae 13-18; Herba Swertiae Puniceae 9-16; Herba Artemisiae Scopariae 12-17; Caulis seu radix berberidis virgetori 9-12; Flos Lonicerae 14-18; Herba Violae mundae 12-14; Fructus Aurantii 9-13.
2. a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis as claimed in claim 1, is characterized in that, Rhizoma Chuanxiong 11-12; Radix Fructus Gardeniae 9-12; Herba Cichorii 11-14; Celastrus aceleatus Merr 14-16; Serissa foetida 12-14; Herba Andrographis 13.5-14.5; Herba Dracocephali tangutici 11.5-12.5; Fructus Viticis Negundo 9-13; Pericarpium Citri Reticulatae 14-17; Herba Swertiae Puniceae 11-14; Herba Artemisiae Scopariae 13-16; Caulis seu radix berberidis virgetori 10-11; Flos Lonicerae 15-17; Herba Violae mundae 12.5-13.5; Fructus Aurantii 10-12(is preferably: Rhizoma Chuanxiong 11.5; Radix Fructus Gardeniae 10.5; Herba Cichorii 12.5; Celastrus aceleatus Merr 15; Serissa foetida 13; Herba Andrographis 14; Herba Dracocephali tangutici 12; Fructus Viticis Negundo 11; Pericarpium Citri Reticulatae 15.5; Herba Swertiae Puniceae 12.5; Herba Artemisiae Scopariae 14.5; Caulis seu radix berberidis virgetori 10.5; Flos Lonicerae 16; Herba Violae mundae 13; Fructus Aurantii 11).
3. a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, add yellow wine and soak 15-25 minute (preferred: to soak 20 minutes), slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate;
(5) made to step (1) (2) crude drug is pulverized, be added in step (4) gained filtrate, stir, obtain decoction.
4. a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament decoction of cholecystitis as claimed in claim 3, it is characterized in that, the amount that step (1) adds yellow wine is the 0.4-0.6 of crude drug quality doubly (preferred: the amount adding yellow wine is 0.5 times of crude drug quality).
5. a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 15-25 minute (preferred: soak 20 minutes), and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, spraying dry, obtains dry thing;
(5) step (1) (2) (4) made crude drug and dry thing are pulverized and sieved, namely subpackage obtains powder.
6. a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament powder of cholecystitis as claimed in claim 5, is characterized in that, it is (preferred: to pulverize 140-200 mesh sieve that step (5) pulverized 100-240 mesh sieve; Be more preferably: pulverized 170 mesh sieves).
7. a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 15-25 minute (preferred: soak 20 minutes), and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, heating is concentrated into thick paste;
(5) made to step (1) (2) crude drug is pulverized, be added in step (4) gained thick paste, dry, be ground into end, be packed in capsule, obtain capsule.
8. a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting drug capsule agent of cholecystitis as claimed in claim 7, is characterized in that, the every capsules Chinese medicine powder content of step (5) is that 0.5-0.7g(is preferred: every capsules Chinese medicine powder content is 0.6g).
9. a kind of depressed liver-energy dispersing and function of gallbladder promoting medicament for the treatment of cholecystitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Herba Andrographis, Herba Dracocephali tangutici, Herba Swertiae Puniceae and Herba Violae mundae wash quickly clean, be cut into thread, dry, pulverize into powder, the yellow wine adding crude drug quality 0.5 times soaks 15-25 minute (preferred: soak 20 minutes), and slow fire is heated to drying, take out, dry in the air cool;
(2) get Fructus Viticis Negundo and Fructus Aurantii to clean, add vinegar water steam 20-30 minute (preferred: to steam 22-28 minute; Be more preferably: steam 25 minutes), take out and cut sheet, be placed in frying pan, add crude salt, stir-fry 10 minutes, take out, sieve and remove crude salt;
(3) Rhizoma Chuanxiong, Radix Fructus Gardeniae, Herba Cichorii, Celastrus aceleatus Merr, Serissa foetida, Pericarpium Citri Reticulatae and Caulis seu radix berberidis virgetori are cleaned, add boiled crude drug quality 5-8 water doubly (preferably: add boiled crude drug quality 6-7 water doubly; Be more preferably: the water adding boiled crude drug quality 6.5 times) soak 15 minutes, big fire is heated to boiling, then adds Flos Lonicerae and Herba Artemisiae Scopariae, and turn little fire and decoct 20-30 minute (preferred: to turn little fire and decoct 25 minutes), filter, collect filtrate, medicinal residues are stand-by;
(4) by step (3) remaining medicinal residues, add water and continue decoction 25 minutes, after closing fire filtration, mix homogeneously with step (3) gained filtrate, heating is concentrated into thick paste;
(5) pulverized by made to step (1) (2) crude drug, be added in step (4) gained thick paste, dry, pulverize, add adjuvant, round sheet dosage form made by tabletting.
10. a kind of preparation method for the treatment of the depressed liver-energy dispersing and function of gallbladder promoting medicament tablet of cholecystitis as claimed in claim 9, is characterized in that, the metering of step (5) tablet is that 0.3-0.6g/ grain is (preferred: the metering of tablet is 0.4-0.5g/ grain; Be more preferably: the metering of tablet is 0.45g/ grain).
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| JPH06135847A (en) * | 1992-07-13 | 1994-05-17 | Tsumura & Co | Gallstone formation inhibitor |
| CN101229304A (en) * | 2008-02-25 | 2008-07-30 | 北京金方华医药科技有限公司 | Chinese thorowax Shugansan oral preparation and preparing method thereof |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06135847A (en) * | 1992-07-13 | 1994-05-17 | Tsumura & Co | Gallstone formation inhibitor |
| CN101229304A (en) * | 2008-02-25 | 2008-07-30 | 北京金方华医药科技有限公司 | Chinese thorowax Shugansan oral preparation and preparing method thereof |
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| Title |
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| 侯桂萍等: "柴胡疏肝散加味配合西药治疗糖尿病合并胆囊炎疗效观察", 《陕西中医》 * |
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Address after: 332000 building 2-102, building 1355, No. ten, Lane 2, Mount Lu, Jiangxi, Jiujiang Applicant after: Wang Yuling Address before: 250000 Ji'nan, China Hi tech Zone, Shandong Chong Hua Road, No. 1587 Applicant before: Wang Yuling |
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Application publication date: 20150715 |