CN105168647A - Traditional Chinese medicine external lotion for treating thromboangiitis obliterans and preparation method - Google Patents
Traditional Chinese medicine external lotion for treating thromboangiitis obliterans and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine external lotion for treating thromboangiitis obliterans. The traditional Chinese medicine external lotion is prepared by, by weight, 8-16 parts of common andrographis herb, 10-13 parts of uncinata spikemoss herb, 7-12 parts of dewberryleaf cinquefoil herb, 9-13 parts of axillary choerospondias bark, 11-17 parts of chrysanthemum, 7-13 parts of calyx-shaped daphniphyllum root, 9-12 parts of Caryopteris mongholica Bgune, 8-14 parts of bloodred iris root and rhizome, 6-13 parts of anderson ironweed stem, 10-14 parts of tuan linden root, 8-15 parts of daghestan sweetclover herb, 9-14 parts of prepared rehmannia root and 7-12 parts of thinleaf buckthorn fruit. The traditional Chinese medicine external lotion is prepared by summarizing clinical practice of many years, has effects of cooling blood and relieving swelling and promoting blood circulation to remove meridian obstruction, and is evident in curative effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the external washout with traditional Chinese herbs agent and method for making for the treatment of thromboangiitis obliterans.
Background technology
Thromboangiitis obliterans is in a kind of rare chronic recurrent, the segmental diseases associated with inflammation of small artery and vein, and lower limb are common.Primary disease is more common in person between twenty and fifty, and suffering limb presents momentary or persistence is pale, cyanosis, have scorching hot and twinge, and when sick limb is sagging, color of the leather reddens, and bleaches during upper act, and then toes are numb, and Calf muscle pain, excites during walking, disappears during rest; Often there is superficial phlebitis and edema in calf.Find during inspection that pulsation of foot dorsal artery weakens or disappears.Along with PD can there is intermittent claudication and Raynaud phenomenon, night, the pain increased, toes sharp ache, skin cyanosis, and then toe-end ulcer or gangrene and turn black, spread to proximal part gradually.Thromboangiitis obliterans is called for short vasculitis, and the traditional Chinese medical science is " necrosis ", " gangrene of toe " etc.Vasculitic pathogenic factor is more complicated, generally freezing surplus because catching cold, causing blood vessel, nerve injury after wound; Be worried or excess of sexual intercourse, the functional disorder of the heart, liver,kidney,spleen can be made, and cause meridians, QI and blood dysfunction and falling ill.
Publication No. CN104800302A(application number 201510154454.9) Chinese patent literature disclose one and treat thromboangiitis obliterans externally applied ointment and preparation method, this externally applied ointment is made up of following raw material of Chinese medicine weight proportion: Flos Carthami 30 ~ 80g, Herba speranskiae tuberculatae 50 ~ 120g, Colophonium 2 ~ 12g, Hirudo 2 ~ 8g, Scorpio 2 ~ 6g, Radix Notoginseng 20 ~ 40g, Cortex Moutan 30 ~ 60g, Caulis Spatholobi 50 ~ 100g, Radix Paeoniae Rubra 50 ~ 100g, Radix Salviae Miltiorrhizae 20 ~ 50g.Publication No. CN104147324A(application number 201410434197.X) Chinese patent literature disclose a kind of external used medicine for the treatment of thromboangiitis obliterans, it is prepared by the raw material of Folium Styracis Suberifoliae Herba Alii fistulosi full stand 10-16, Herba Xanthii Seedling 10-16, Pericarpium Zanthoxyli 8-12.Publication No. CN102872258A(application number 201210312047.2) Chinese patent literature disclose a kind of external used medicine for the treatment of thromboangiitis obliterans, it is characterized in that, the concrete proportioning of this external used medicine is: fresh common chicken blood 200ml, eupolyphaga 30 grams, Ramulus Cinnamomi 15 grams, Fructus Chaenomelis 30 grams, 30 grams, Radix Rehmanniae Preparata, Radix Scrophulariae 30 grams, 40 grams, the seed of potherb mustard, the degree of accuracy of the dose of this prescription be each medicine ± 10%.
Sick for this, it is little that treatment by Chinese herbs has side effect, the advantage that anti-recurrence rate is effective, can stablize, mitigate the disease, part Chinese medicine formula Clinical Practice, and therapeutic effect is poor, therefore needs to work out Be very effective, formula that anti-relapse rate is high.
Summary of the invention
For the problem of prior art, the object of this invention is to provide external washout with traditional Chinese herbs agent and the method for making of the wide treatment thromboangiitis obliterans of a kind of Be very effective, the use safety suitability.
Technical scheme of the present invention is:
The external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans, is prepared from primarily of following bulk drugs, is mass parts: Herba Andrographis 8-16; CUIYUNCAO 10-13; Herba Potentillae Fragarioidis 7-12; Cortex Choerospondiatis 9-13; Flos Chrysanthemi 11-17; Radix Daphniphylli calycini 7-13; Blue scented tea 9-12; Radix et Rhizoma Iridis Sanguineae 8-14; Caulis Vernoniae Andersonii 6-13; Radix Tiliae 10-14; Herba Meliloti Suaveolentis 8-15; Radix Rehmanniae Preparata 9-14; Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 7-12.
Preferred version is, Herba Andrographis 10-14; CUIYUNCAO 11-12; Herba Potentillae Fragarioidis 9-10; Cortex Choerospondiatis 10-12; Flos Chrysanthemi 13-15; Radix Daphniphylli calycini 9-11; Blue scented tea 10-11; Radix et Rhizoma Iridis Sanguineae 10-12; Caulis Vernoniae Andersonii 8-11; Radix Tiliae 11-13; Herba Meliloti Suaveolentis 10-13; Radix Rehmanniae Preparata 10-13; Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9-10.
More preferably, Herba Andrographis 12; CUIYUNCAO 11.5; Herba Potentillae Fragarioidis 9.5; Cortex Choerospondiatis 11; Flos Chrysanthemi 14; Radix Daphniphylli calycini 10; Blue scented tea 10.5; Radix et Rhizoma Iridis Sanguineae 11; Caulis Vernoniae Andersonii 9.5; Radix Tiliae 12; Herba Meliloti Suaveolentis 11.5; Radix Rehmanniae Preparata 11.5; Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9.5.
The preparation method of the external washout with traditional Chinese herbs agent of described treatment thromboangiitis obliterans, step is as follows:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 4-6 water doubly (preferred: the water adding Semen Bauhiniae championii quality 5 times) decoction to boiling, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, adds alcoholic solution and there was not medical material 1-2cm, soaks 10-20 minute (preferred: immersion 12-18 minute; Be more preferably: soak 15 minutes), heating and refluxing extraction twice, filters and merges extracted twice liquid, and extracting solution reclaims ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, decoct with water twice, each decocting time is 18-26 minute, after filtration, collects filtrate;
(5) pulverized and sieved by step (1) made crude drug, mix with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
The preparation method of the external washout with traditional Chinese herbs agent of described treatment thromboangiitis obliterans, step (1) is placed in vinegar water and soaks 5-15 minute (preferably: soak 8-12 minute; Be more preferably: soak 10 minutes).
The preparation method of the external washout with traditional Chinese herbs agent of described treatment thromboangiitis obliterans, time of each reflux, extract, of step (3) be 60-90 minute (preferred: the time of each reflux, extract, is 70-80 minute; Be more preferably: the time of each reflux, extract, is 75 minutes).
The preparation method of the external washout with traditional Chinese herbs agent of described treatment thromboangiitis obliterans, step (4) twice amount of water is the 6-9 of boiled crude drug quality doubly (preferably: each amount of water is the 7-8 of boiled crude drug quality doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality).
The preparation method of the external washout with traditional Chinese herbs agent of described treatment thromboangiitis obliterans, each decocting time of step (4) is 20-24 minute (preferred: each decocting time is 22 minutes).
The preparation method of the external washout with traditional Chinese herbs agent of described treatment thromboangiitis obliterans, it is (preferred: to pulverize 160-200 mesh sieve that step (5) pulverized 120-240 mesh sieve; Be more preferably: pulverized 180 mesh sieves).
Present invention also offers the application of external washout with traditional Chinese herbs agent when preparing the medicine for the treatment of thromboangiitis obliterans of described treatment thromboangiitis obliterans.
The external washout with traditional Chinese herbs agent prescription science for the treatment of thromboangiitis obliterans provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, effectively can reduce relapse rate;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of removing heat from blood detumescence, promoting blood circulation to remove obstruction in the collateral;
3, Chinese crude drug selected by the present invention, safety has no side effect, and wide material sources are cheap.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Andrographis 8 parts, CUIYUNCAO 10 parts, Herba Potentillae Fragarioidis 7 parts, Cortex Choerospondiatis 9 parts, Flos Chrysanthemi 11 parts, Radix Daphniphylli calycini 7 parts, blue scented tea 9 parts, Radix et Rhizoma Iridis Sanguineae 8 parts, Caulis Vernoniae Andersonii 6 parts, Radix Tiliae 10 parts, Herba Meliloti Suaveolentis 8 parts, Radix Rehmanniae Preparata 9 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 7 parts.The preparation method of the external washout with traditional Chinese herbs agent of above-mentioned treatment thromboangiitis obliterans is:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak 5 minutes, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds the soak by water extremely boiling of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 4 times, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, add alcoholic solution and do not have medical material 1-2cm, soaks 10 minutes, heating and refluxing extraction twice, the time of each reflux, extract, is 60 minutes, filters and merges extracted twice liquid, extracting solution recovery ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, add the soak by water twice of 6 times of boiled crude drug quality, each decocting time is 18 minutes, after filtration, collects filtrate;
(5) step (1) made crude drug was pulverized 120 mesh sieves, and mixed with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
embodiment 2the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Andrographis 16 parts, CUIYUNCAO 13 parts, Herba Potentillae Fragarioidis 12 parts, Cortex Choerospondiatis 13 parts, Flos Chrysanthemi 17 parts, Radix Daphniphylli calycini 13 parts, blue scented tea 12 parts, Radix et Rhizoma Iridis Sanguineae 14 parts, Caulis Vernoniae Andersonii 13 parts, Radix Tiliae 14 parts, Herba Meliloti Suaveolentis 15 parts, Radix Rehmanniae Preparata 14 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 12 parts.The preparation method of the external washout with traditional Chinese herbs agent of above-mentioned treatment thromboangiitis obliterans is:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak 15 minutes, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds the soak by water extremely boiling of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 6 times, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, add alcoholic solution and do not have medical material 1-2cm, soaks 20 minutes, heating and refluxing extraction twice, the time of each reflux, extract, is 90 minutes, filters and merges extracted twice liquid, extracting solution recovery ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, add the soak by water twice of 9 times of boiled crude drug quality, each decocting time is 26 minutes, after filtration, collects filtrate;
(5) step (1) made crude drug was pulverized 240 mesh sieves, and mixed with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
Model case: xxx, male, 45 years old.Main suit: both feet send out cool, numb, toe festers; Medical history: patient is from the year before, and both feet are afraid of cold, after numb, pain gradually, slightly alleviate after rest, night, the pain increased, and impact sleep, to hospital diagnosis, being diagnosed as thromboangiitis obliterans, because being unwilling to carry out operative treatment, then finding tcm methods.
Use the agent of this example gained external washout with traditional Chinese herbs, one day twice, cleaning affected part, it within 30 days, is a course for the treatment of, after patient uses ten days, pain symptom is alleviated to some extent, and spirit and muscle power increase to some extent, after adhering to two courses for the treatment of of use, fester disappearance, fresh granulation tissue grows, and patient fully recovers, follow up a case by regular visits in half a year, do not recur.
embodiment 3the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Andrographis 10 parts, CUIYUNCAO 11 parts, Herba Potentillae Fragarioidis 9 parts, Cortex Choerospondiatis 10 parts, Flos Chrysanthemi 13 parts, Radix Daphniphylli calycini 9 parts, blue scented tea 10 parts, Radix et Rhizoma Iridis Sanguineae 10 parts, Caulis Vernoniae Andersonii 8 parts, Radix Tiliae 11 parts, Herba Meliloti Suaveolentis 10 parts, Radix Rehmanniae Preparata 10 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9 parts.The preparation method of the external washout with traditional Chinese herbs agent of above-mentioned treatment thromboangiitis obliterans is:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak 8 minutes, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds the soak by water extremely boiling of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 4 times, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, add alcoholic solution and do not have medical material 1-2cm, soaks 12 minutes, heating and refluxing extraction twice, the time of each reflux, extract, is 70 minutes, filters and merges extracted twice liquid, extracting solution recovery ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, add the soak by water twice of 7 times of boiled crude drug quality, each decocting time is 20 minutes, after filtration, collects filtrate;
(5) step (1) made crude drug was pulverized 160 mesh sieves, and mixed with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
embodiment 4the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Andrographis 14 parts, CUIYUNCAO 12 parts, Herba Potentillae Fragarioidis 10 parts, Cortex Choerospondiatis 12 parts, Flos Chrysanthemi 15 parts, Radix Daphniphylli calycini 11 parts, blue scented tea 11 parts, Radix et Rhizoma Iridis Sanguineae 12 parts, Caulis Vernoniae Andersonii 11 parts, Radix Tiliae 13 parts, Herba Meliloti Suaveolentis 13 parts, Radix Rehmanniae Preparata 13 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 10 parts.The preparation method of the external washout with traditional Chinese herbs agent of above-mentioned treatment thromboangiitis obliterans is:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak 12 minutes, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds the soak by water extremely boiling of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 6 times, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, add alcoholic solution and do not have medical material 1-2cm, soaks 18 minutes, heating and refluxing extraction twice, the time of each reflux, extract, is 80 minutes, filters and merges extracted twice liquid, extracting solution recovery ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, add the soak by water twice of 8 times of boiled crude drug quality, each decocting time is 24 minutes, after filtration, collects filtrate;
(5) step (1) made crude drug was pulverized 200 mesh sieves, and mixed with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
Model case: xxx, male, 36 years old.Medical history: patient must have thromboangiitis obliterans half a year, existing symptom is that lower limb are sent out cool, and intermittent claudication, a segment distance of walking, shank distending pain, can alleviate after rest, and night, the pain increased, moans ceaselessly, and once takes many medicines and treats, and effect is very not remarkable.
Introduce through friend and use the agent of this example gained external washout with traditional Chinese herbs, one day twice, cleaning affected part 30 days is a course for the treatment of, after patient uses a course for the treatment of, pain obviously alleviates, and continue a course for the treatment of, uncomfortable disease is all eliminated, can normally walk, patient fully recovers, and follow up a case by regular visits to after 1 year, the state of an illness does not recur again.
embodiment 5the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Andrographis 12 parts, CUIYUNCAO 11.5 parts, Herba Potentillae Fragarioidis 9.5 parts, Cortex Choerospondiatis 11 parts, Flos Chrysanthemi 14 parts, Radix Daphniphylli calycini 10 parts, blue scented tea 10.5 parts, Radix et Rhizoma Iridis Sanguineae 11 parts, Caulis Vernoniae Andersonii 9.5 parts, Radix Tiliae 12 parts, Herba Meliloti Suaveolentis 11.5 parts, Radix Rehmanniae Preparata 11.5 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9.5 parts.The preparation method of the external washout with traditional Chinese herbs agent of above-mentioned treatment thromboangiitis obliterans is:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak 10 minutes, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds the soak by water extremely boiling of Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 5 times, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, add alcoholic solution and do not have medical material 1-2cm, soaks 15 minutes, heating and refluxing extraction twice, the time of each reflux, extract, is 75 minutes, filters and merges extracted twice liquid, extracting solution recovery ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, add the soak by water twice of 7.5 times of boiled crude drug quality, each decocting time is 22 minutes, after filtration, collects filtrate;
(5) step (1) made crude drug was pulverized 180 mesh sieves, and mixed with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.Nature and flavor: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." return through: " Quanzhou book on Chinese herbal medicine ": " enters the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.Pharmacological action: 1. antibacterial action 2. antivirus action 3. other effects.
CUIYUNCAO: base is former: be the herb of Selaginaceae Rock lily plant CUIYUNCAO.The property of medicine: light, micro-hardship, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances, hemostasis.Cure mainly jaundice, dysentery, have loose bowels, edema, gonorrhea, myalgia, spit blood, spitting of blood, has blood in stool, traumatic hemorrhage, anal fistula, burn and scald, venom.
Herba Potentillae Fragarioidis: base is former: be the herb of rosaceous plant strawberry cinquefoil root.Nature and flavor: sweet; Temperature.Gui Jing: lung; Spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, replenishing YIN and removing heat.Main hernia, an emaciation due to blood disorder.
Cortex Choerospondiatis: base is former: be the bark of Anacardiaceae plant Fructus Choerospondiatis.Nature and flavor: acid; Puckery; Cool.Gui Jing: spleen; Stomach warp.Function cures mainly: heat-clearing and toxic substances removing; Damp eliminating; Parasite killing.Main skin infection; Burn and scald; Eczema scrotum; Dysentery; Leucorrhea; Skin ulcer tinea.
Flos Chrysanthemi: chemical analysis: flower and stem containing volatile oil, and have adenine, choline, stachydrine etc.Flower is again containing chrysanthemum glycoside, aminoacid, flavonoid and mcg vitamin B1.Volatile oil is mainly containing Borneolum Syntheticum, Camphora, chrysanthenone etc.Flavonoid has luteolin-7-glycoside, cosmosiin, acaciin.Still containing aminozide.Nature and flavor: sweetness and bitterness are cool.Gui Jing: enter lung, Liver Channel.Function cures mainly: dispelling wind, heat clearing away, improving eyesight, removing toxic substances.Control headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.
Radix Daphniphylli calycini: base is former: be the root of Daphniphyllaceae plant Daphniphyllum calycinum.Nature and flavor: acrid in the mouth; Bitter; Cool in nature; Mild toxicity.Gui Jing: lung; Large intestine channel.Function cures mainly: heat-clearing and toxic substances removing; Blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain.Main fever caused by exogenous pathogens; Cough; Laryngopharynx swelling and pain; The lower mass in the abdomen of the side of body; Rheumatic ostalgia; Traumatic injury.
Blue scented tea: base is former: be the young stem and leaf of Verenaceae Caryopteris plants mongolian bluebeard.The property of medicine: acrid, sweet, warm.Function cures mainly: regulate the flow of vital energy and help digestion, inducing diuresis to remove edema.Cure mainly diet not disappear, distension and fullness in the abdomen, edema, dysuria, rheumatic lumbocrural pain pain.
Radix et Rhizoma Iridis Sanguineae: base is former: be root or the herb of the long sequence Rhizoma et radix valerianae of Valerianaceae plant.Nature and flavor: acrid in the mouth; Sweet; Property is put down.Function cures mainly: promoting blood flow to regulate menstruation; Expelling wind and removing dampness; Spleen invigorating removing food stagnancy.Main menoxenia; Dysmenorrhea is closed; Rheumatic arthralgia; Dysuria; Infantile malnutrition; Traumatic pain; Vasculitis.
Caulis Vernoniae Andersonii: base is former: be rattan and the root of feverfew poison root Herba Vernonia esculenta.Nature and flavor: bitter in the mouth; Pungent; Slightly warm in nature; Poisonous.Function cures mainly: expelling pathogenic wind from the body surface; Relaxing muscles and tendons and activating QI and blood in the collateral.Main flu; Malaria; Laryngalgia; Toothache; Wind-fire acute conjunctivitis; Rheumatic arthralgia; Lumbar muscle strain; Traumatic injury.
Radix Tiliae: base is former: be the root of Cornaceae plant blue or green pod leaf Himalaya Helaingia Helwingia chinensis.Nature and flavor: acrid in the mouth; Micro-sweet; Property is put down.Function cures mainly: relieving cough and asthma; Promoting blood circulation to remove obstruction in the collateral.Main chronic cough dyspnea due to deficiency; Impairment caused by overstrain lumbago; Rheumatic arthralgia; Treating swelling and pain by traumatic injury; Stomachache; Menoxenia; Puerperal abdonimal pain.
Herba Meliloti Suaveolentis: base is former: be the herb of leguminous plant melilotus.Nature and flavor: pungent; Sweet; Micro-hardship; Cool in nature; Mild toxicity.Gui Jing: liver; Spleen; Stomach warp.Function cures mainly: clearing away summer-heat and eliminating dampness; Stomach invigorating and in.Main heat-damp in summer breast is vexed; Feeling of fullness in the head is had a headache; Dysentery; Malaria; Stranguria; Leukorrhagia; Aphtha; Halitosis; Skin infection; Eczema; Scabies; Lymphoid tuberculosis.
Radix Rehmanniae Preparata: base is former: for the rhizome of Radix Rehmanniae is celebrated in scrophulariaceae rehmannia glutinosa plant or bosom, steam solarization through processing and form.Nature and flavor with return through: sweet, tepor.Return liver, kidney channel.Function with cure mainly: YIN nourishing, enrich blood.Control deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.
: Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) base is former: be the fruit of Rhamnaceae plant fineflower buckthorn.Nature and flavor: bitter; Puckery; Flat.Gui Jing: the heart; Spleen; Kidney channel.Function cures mainly: relieving dyspepsia; Row water can be just.Main dyspeptic abdominal distention; Edema; Ascites; Constipation.
test example 1the clinical practice of the external washout with traditional Chinese herbs agent (embodiment 5) of gained treatment thromboangiitis obliterans of the present invention:
Choose crowd: in May ,-2015 in April, 2014, according to medical case history, have patient 252 example of thromboangiitis obliterans six hospital's screenings, age 20-55 year, 36.8 ± 2.6 years old mean age, the course of disease 3 months-4 years, wherein male patient 220 example, female patient 32 example.Diagnostic criteria: 1. most of case is male adults (20-40 years old), and majority has smoking to have a liking for.2. suffering limb have the intermittent claudication increased the weight of gradually in various degree and chronic ischemic symptom (as numb, be afraid of cold, pain, pale).3. there is the migrans superficial phlebitis of recurrent before ill or in pathogenic process.4. suffering limb dorsal artery of foot or posterior tibial artery are beaten and are weakened or disappear.5. generally arteriosclerotic factor is easily caused without hypertension, hyperlipemia, diabetes etc.6. angiography has typical X sign.7. Burger test or Allen test are positive.8. Differential Diagnosis, gets rid of Other diseases.
Before test, patient is divided into two groups at random, experimental group 140 example and matched group 112 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, one day twice, and cleaning affected part 30 days is a course for the treatment of; Matched group takes other conventional medicines (MAILUONING, vasculitis sheet, vascular recovery capsule etc.).Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cure: clinical symptoms disappears substantially, and limbs wound surface heals completely, and distal limb disturbance of blood circulation and impedance type rheography obviously improve, walking speed 100 ~ 120m/min, and walking can be continued be about more than 1500m without uncomfortable; (2) effective: clinical symptoms is obviously improved, limbs wound healing or close healing, distal limb disturbance of blood circulation and rheography are all improved, walking speed 100 ~ 120m/min, can continue walking and be about more than 500m; (3) take a turn for the better: clinical symptom relief, limbs wound surface is close to healing or reduce, and distal limb blood circulation and rheography slightly improve, walking speed 100 ~ 120m/min, and can walk about 300m; (4) invalid: after treatment, symptom and sign continue to increase the weight of without progressive or the state of an illness.
Clinical effectiveness: after the medication of two courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the healing patient of experimental group is 89 examples, and effective patient is 30 examples, and improvement patient is 17 examples, total effective rate is 97.1%, and the patient that matched group is cured is 51 examples, effective patient is 22 examples, and the patient of improvement is 18 examples, total effective rate 81.2%, be starkly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The Chinese medicine used in the present invention, the Herba Andrographis of removing heat from blood detumescence, the CUIYUNCAO of clearing away heat-damp and promoting diuresis, the Herba Potentillae Fragarioidis of blood circulation promoting and blood stasis dispelling, the Cortex Choerospondiatis of heat-clearing and toxic substances removing, the Flos Chrysanthemi of wind and heat dispersing, the Radix Daphniphylli calycini of reducing swelling and alleviating pain, the blue scented tea helped digestion of regulating the flow of vital energy, the Radix et Rhizoma Iridis Sanguineae of promoting blood flow to regulate menstruation, the Caulis Vernoniae Andersonii of relaxing muscles and tendons and activating QI and blood in the collateral, the Radix Tiliae of promoting blood circulation to remove obstruction in the collateral, stomach invigorating and in Herba Meliloti Suaveolentis, the Radix Rehmanniae Preparata of nourishing YIN and supplementing blood, the Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) of relieving dyspepsia, multiple medical material synergism, can give play to effect of removing heat from blood detumescence, promoting blood circulation to remove obstruction in the collateral.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the external washout with traditional Chinese herbs agent of thromboangiitis obliterans, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Herba Andrographis 8-16; CUIYUNCAO 10-13; Herba Potentillae Fragarioidis 7-12; Cortex Choerospondiatis 9-13; Flos Chrysanthemi 11-17; Radix Daphniphylli calycini 7-13; Blue scented tea 9-12; Radix et Rhizoma Iridis Sanguineae 8-14; Caulis Vernoniae Andersonii 6-13; Radix Tiliae 10-14; Herba Meliloti Suaveolentis 8-15; Radix Rehmanniae Preparata 9-14; Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 7-12.
2. the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 1, is characterized in that, Herba Andrographis 10-14; CUIYUNCAO 11-12; Herba Potentillae Fragarioidis 9-10; Cortex Choerospondiatis 10-12; Flos Chrysanthemi 13-15; Radix Daphniphylli calycini 9-11; Blue scented tea 10-11; Radix et Rhizoma Iridis Sanguineae 10-12; Caulis Vernoniae Andersonii 8-11; Radix Tiliae 11-13; Herba Meliloti Suaveolentis 10-13; Radix Rehmanniae Preparata 10-13; Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9-10.
3. the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 1, is characterized in that, Herba Andrographis 12; CUIYUNCAO 11.5; Herba Potentillae Fragarioidis 9.5; Cortex Choerospondiatis 11; Flos Chrysanthemi 14; Radix Daphniphylli calycini 10; Blue scented tea 10.5; Radix et Rhizoma Iridis Sanguineae 11; Caulis Vernoniae Andersonii 9.5; Radix Tiliae 12; Herba Meliloti Suaveolentis 11.5; Radix Rehmanniae Preparata 11.5; Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 9.5.
4. the preparation method of the external washout with traditional Chinese herbs agent of the treatment thromboangiitis obliterans as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Cortex Choerospondiatis, Radix Daphniphylli calycini, Caulis Vernoniae Andersonii, Radix Tiliae and Radix Rehmanniae Preparata and clean remove impurity, be placed in vinegar water and soak, take out, section, mixes with rice, is placed in frying pan, and moderate heat is fried to dry, takes out, and sieve removes rice;
(2) get Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) and put into frying pan, moderate heat heats, and constantly stir-fries 5 minutes, after mashing, adds ginger slice, then adds Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) quality 4-6 water doubly (preferred: the water adding Semen Bauhiniae championii quality 5 times) decoction to boiling, after filtration, collects filtrate
(3) get Flos Chrysanthemi and blue scented tea wash quickly clean, chopping, adds alcoholic solution and there was not medical material 1-2cm, soaks 10-20 minute (preferred: immersion 12-18 minute; Be more preferably: soak 15 minutes), heating and refluxing extraction twice, filters and merges extracted twice liquid, and extracting solution reclaims ethanol;
(4) Herba Andrographis, CUIYUNCAO, Herba Potentillae Fragarioidis, Radix et Rhizoma Iridis Sanguineae and Herba Meliloti Suaveolentis are cleaned remove impurity, be placed in marmite, decoct with water twice, each decocting time is 18-26 minute, after filtration, collects filtrate;
(5) pulverized and sieved by step (1) made crude drug, mix with step (2) (3) (4) gained filtrate and extracting solution, heating is concentrated into the half of original volume, namely obtains outer lotion after filtration.
5. the preparation method of the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 4, is characterized in that, step (1) is placed in vinegar water and soaks 5-15 minute (preferably: soak 8-12 minute; Be more preferably: soak 10 minutes).
6. the preparation method of the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 4, is characterized in that, time of each reflux, extract, of step (3) be 60-90 minute (preferred: the time of each reflux, extract, is 70-80 minute; Be more preferably: the time of each reflux, extract, is 75 minutes).
7. the preparation method of the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 4, it is characterized in that, step (4) twice amount of water is the 6-9 of boiled crude drug quality doubly (preferably: each amount of water is the 7-8 of boiled crude drug quality doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality).
8. the preparation method of the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 4, is characterized in that, each decocting time of step (4) is 20-24 minute (preferred: each decocting time is 22 minutes).
9. the preparation method of the external washout with traditional Chinese herbs agent for the treatment of thromboangiitis obliterans as claimed in claim 4, it is characterized in that, it is (preferred: to pulverize 160-200 mesh sieve that step (5) pulverized 120-240 mesh sieve; Be more preferably: pulverized 180 mesh sieves).
10. the application of external washout with traditional Chinese herbs agent when preparing the medicine for the treatment of thromboangiitis obliterans of the treatment thromboangiitis obliterans as described in as arbitrary in claim 1-3.
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Address after: 719000 Shaanxi, Yuyang District, Shi Shi Shi Road, No. 15 sunshine District, building 3-201, 1 Applicant after: Huo Chuanying Address before: Zhang Zhuang Lu, Huaiyin District of Ji'nan city of Shandong Province, No. 19 250000 Applicant before: Huo Chuanying |
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Application publication date: 20151223 |