CN104784388A - Traditional Chinese medicine externally applied patch for treating lymphnoditis and preparation method thereof - Google Patents

Traditional Chinese medicine externally applied patch for treating lymphnoditis and preparation method thereof Download PDF

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CN104784388A
CN104784388A CN201510239305.2A CN201510239305A CN104784388A CN 104784388 A CN104784388 A CN 104784388A CN 201510239305 A CN201510239305 A CN 201510239305A CN 104784388 A CN104784388 A CN 104784388A
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herba
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chinese medicine
lymphadenitis
external application
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范道锋
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Abstract

The invention discloses a traditional Chinese medicine externally applied patch for treating lymphnoditis. The traditional Chinese medicine externally applied patch is prepared from the following raw material medicines in parts by weight: 12-16 parts of rhizoma alismatis, 9-13 parts of Erigeron annuus, 7-12 parts of trichosanthes palmate, 13-17 parts of Platycodon grandiflorum, 10-18 parts of leaf of Chinese Hibiscus, 8-16 parts of Lepidogrammitis drymoglossoides Ching, 12-18 parts of Salvia miltiorrhiza, 10-16 parts of Indigofera tinctoria, 8-17 parts of tuber fern, 9-13 parts of Lemmaphyllum microphyllum, 11-17 parts of Dracocephalum heterophyllum, 8-12 parts of purslane, 12-16 parts of dandelion and 10-14 parts of herba andrographitis. The clinical practices for many years summarize that the traditional Chinese medicine externally applied patch has the heat-clearing and detoxicating, antisepsis and anti-inflammation functions and has an obvious effect.

Description

A kind of external application of Chinese medicine patch and method for making for the treatment of lymphadenitis
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of external application of Chinese medicine patch and method for making for the treatment of lymphadenitis.
Background technology
Lymphadenitis is the nonspecific inflammation that the Acute and chronic inflammation in drain region belonging to lymph node involves caused by lymph node, and according to onset emergency, course of disease length, lymphadenitis can be divided into acute and chronic lymphadenitis.Acute lymphadenitis has the acute inflammation features such as red, swollen, hot, the pain in local, onset urgency, and often occur together heat, the lymph node softness of enlargement, has tenderness, smooth surface, and without adhesion, namely enlargement extremely to a certain degree stops.Can be disappeared by redness after timely anti-infective therapy.Also abscess can be developed into, with systemic infection symptom during aggravation.The chronic lymphadenitis course of disease is long, mild symptoms, and lymph node is comparatively hard, and movable, tenderness is not obvious, and final lymph node can reduce or disappear.The treatment of acute lymphadenitis, mainly for the timely process of primary lesion; Antibiotic application; Take a good rest; Incision and drainage are answered when being partially formed abscess; And chronic lymphadenitis is usually without the need to special treatment.
Publication No. CN 103638182 A(application number 201310615773.6) Chinese patent literature disclose a kind of Chinese medicine for outer use for the treatment of acute lymphadenitis, be made up of the raw material of Chinese medicine of following parts by weight: Mirabilitum crystallina 5 parts, Herba Duchesneae Indicae 4 parts, Herba Andrographis 2 parts, Herba veronicastri villosuli 3 parts, Borneolum Syntheticum 1 part.Publication No. CN 102885995 A(application number 201210438111.1) Chinese patent literature disclose a kind of Chinese medicine for the treatment of acute lymphadenitis, be made up of the raw material of Chinese medicine of following weight ratio: Fructus Forsythiae 8-12g, Fructus Arctii 8-12g, Retinervus Luffae Fructus 9-11g, Radix Paeoniae Rubra 10-12g, Rhizoma Coptidis 7-9g, Rhizoma Pinelliae 8-11g, Spica Prunellae 9-11g, Semen Benincasae 8-10g, Cortex Phellodendri 12-14g, Semen Plantaginis 8-10g, Cortex Moutan 7-9g, Rhizoma Dioscoreae Septemlobae 14-16g, Radix Pseudostellariae 18-20g, Radix Trichosanthis 5-7g, Pericarpium Citri Reticulatae 9-11g, Fructus Corni 12-14g, Fructus Schisandrae Chinensis 4-6g, Gypsum Fibrosum 15-20g, Radix Scutellariae 12-15g, Radix Et Rhizoma Rhei 6-8g, Herba Lophatheri 11-13g, Fructus Gardeniae 5-9g, Radix Saposhnikoviae 12-15g.Publication No. CN 103479980 A(application number 201310431398.X) Chinese patent literature disclose a kind of plaster for the treatment of acute lymphadenitis, the weight proportion of its each raw material components is: Hirudo 10-14, Herba Andrographis 13-17, Radix Aconiti 10-14, Centranthera grandiflora Benth 6-10, Cortex Cinnamomi 13-17, Semen Coicis 6-10, Flos Rosae Chinensis 4-8, Myrrha 4-8, Herba Asari 1-5, Herba Verbenae 4-8, Rhizoma Zingiberis 6-10, Turpinia arguta Seem 10-14, Moschus 1-5, Asplenium normale Don 6-10, LUBIANHUANG 13-17.
Western medical treatment is based on antibiotic, and it is large to take rear side effect, and relapse rate is high, and adopts Chinese traditional treatment, can treating both the principal and secondary aspects of a disease, and determined curative effect, has advantage better, therefore needs to develop a kind of instant effect, eutherapeutic Chinese medicine formula.
Summary of the invention
For the problem of prior art, the object of this invention is to provide external application of Chinese medicine patch and the method for making of the wide treatment lymphadenitis of a kind of Be very effective, the use safety suitability.
Technical scheme of the present invention is:
Treat an external application of Chinese medicine patch for lymphadenitis, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Alismatis 12-16; Herba Erigerontis Annui 9-13; Radix Stephaniae Cepharanthae 7-12; Radix Platycodonis 13-17; Folium Hibisci Rosae-Sinensis 10-18; Lepidogrammitis drymoglossoides (Bak.) Ching 8-16; Radix Salviae Miltiorrhizae 12-18; Folium et Caulis Indigoferae Tinctoriae 10-16; Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 8-17; Drymoglossum Herba Drymoglossi 9-13; Spend very sweet 11-17 in vain; Herba Portulacae 8-12; Herba Taraxaci 12-16; Herba Andrographis 10-14.
Preferred version is, Rhizoma Alismatis 13-15; Herba Erigerontis Annui 10-12; Radix Stephaniae Cepharanthae 9-10; Radix Platycodonis 14-16; Folium Hibisci Rosae-Sinensis 12-16; Lepidogrammitis drymoglossoides (Bak.) Ching 10-14; Radix Salviae Miltiorrhizae 14-16; Folium et Caulis Indigoferae Tinctoriae 12-14; Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 10-15; Drymoglossum Herba Drymoglossi 10-12; Spend very sweet 13-15 in vain; Herba Portulacae 9-11; Herba Taraxaci 13-15; Herba Andrographis 11-13.
More preferably, Rhizoma Alismatis 14; Herba Erigerontis Annui 11; Radix Stephaniae Cepharanthae 9.5; Radix Platycodonis 15; Folium Hibisci Rosae-Sinensis 14; Lepidogrammitis drymoglossoides (Bak.) Ching 12; Radix Salviae Miltiorrhizae 15; Folium et Caulis Indigoferae Tinctoriae 13; Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12.5; Drymoglossum Herba Drymoglossi 11; Spend very sweet 14 in vain; Herba Portulacae 10; Herba Taraxaci 14; Herba Andrographis 12.
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, step is as follows:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, fumigate with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, it is (preferred: dipping 16-20 hour to add alcoholic solution dipping 14-22 hour; Be more preferably: flood 18 hours), then carry out percolation, collect and filter liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, big fire is heated to boiling, and turn little fire and decoct, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) made to step (1) (3) crude drug is pulverized, mix with filter liquid and filtrate of step (2) (4) gained, heat and be concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, step (1) fumigates 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar).
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, the concentration of step (2) ethanol is that 50%-80%(is preferred: the concentration of ethanol is 60%-70%; Be more preferably: the concentration of ethanol is 65%).
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, soaks 24-36 minute (preferably: soak 28-32 minute in saline in step (3) saline; Be more preferably: soak 30 minutes in saline).
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, step (4) turns little fire and decocts 32-46 minute (preferably: turn little fire and decoct 36-42 minute; Be more preferably: turn little fire and decoct 39 minutes).
Described a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis, it is (preferred: to pulverize 120-160 mesh sieve that step (5) pulverized 100-180 mesh sieve; Be more preferably: pulverized 140 mesh sieves).
A kind of external application of Chinese medicine patch scientific formulation for the treatment of lymphadenitis provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, effectively can reduce relapse rate;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of heat-clearing and toxic substances removing, anti-inflammation;
3, Chinese crude drug selected by the present invention, safety has no side effect, and drug effect directly acts on focus, instant effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat an external application of Chinese medicine patch for lymphadenitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Alismatis 12 parts, Herba Erigerontis Annui 9 parts, Radix Stephaniae Cepharanthae 7 parts, Radix Platycodonis 13 parts, Folium Hibisci Rosae-Sinensis 10 parts, Lepidogrammitis drymoglossoides (Bak.) Ching 8 parts, Radix Salviae Miltiorrhizae 12 parts, Folium et Caulis Indigoferae Tinctoriae 10 parts, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 8 parts, Drymoglossum Herba Drymoglossi 9 parts, spends very sweet 11 parts in vain, Herba Portulacae 8 parts, Herba Taraxaci 12 parts, Herba Andrographis 10 parts.Above-mentioned a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis is:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, with stifling 18 minutes of vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, to add concentration be concentration is that 50% alcoholic solution floods 14 hours, then carries out percolation, collects and filters liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak 24 minutes, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, amount of water is 5 times of boiled crude drug quality, big fire is heated to boiling, turns little fire and decocts 32 minutes, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) step (1) (3) made crude drug was pulverized 100 mesh sieves, mix with filter liquid and filtrate of step (2) (4) gained, heating is concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
embodiment 2treat an external application of Chinese medicine patch for lymphadenitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Alismatis 16 parts, Herba Erigerontis Annui 13 parts, Radix Stephaniae Cepharanthae 12 parts, Radix Platycodonis 17 parts, Folium Hibisci Rosae-Sinensis 18 parts, Lepidogrammitis drymoglossoides (Bak.) Ching 16 parts, Radix Salviae Miltiorrhizae 18 parts, Folium et Caulis Indigoferae Tinctoriae 16 parts, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 17 parts, Drymoglossum Herba Drymoglossi 13 parts, spends very sweet 17 parts in vain, Herba Portulacae 12 parts, Herba Taraxaci 16 parts, Herba Andrographis 14 parts.Above-mentioned a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis is:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, with stifling 34 minutes of vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, to add concentration be concentration is that 80% alcoholic solution floods 22 hours, then carries out percolation, collects and filters liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak 36 minutes, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, amount of water is 8 times of boiled crude drug quality, big fire is heated to boiling, turns little fire and decocts 46 minutes, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) step (1) (3) made crude drug was pulverized 180 mesh sieves, mix with filter liquid and filtrate of step (2) (4) gained, heating is concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
Model case: xxx, male, 34 years old.Main suit: generate heat three days, cervical lymph node enlargement, pain; Medical history: find before patient's first quarter moon that cervical region has scleroma, pressing, without pain, is just not placed in the heart, and rear caking increases, clear border, movable good, pressing pain, and with heating paresthesia, through hospital diagnosis, quantity of leucocyte increases, and is diagnosed as acute lymphadenitis.
Use this example gained external plaster application agent, each one pastes, and within two days, changes once, within ten days, is a course for the treatment of, after patient uses a course for the treatment of, lymphadenectasis is alleviated, and routine blood test recovers normal, after continuing a course for the treatment of of use, lymph node recovers normal, and patient fully recovers, and follows up a case by regular visits to, do not recur after 1 year.
embodiment 3treat an external application of Chinese medicine patch for lymphadenitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Alismatis 13 parts, Herba Erigerontis Annui 10 parts, Radix Stephaniae Cepharanthae 9 parts, Radix Platycodonis 14 parts, Folium Hibisci Rosae-Sinensis 12 parts, Lepidogrammitis drymoglossoides (Bak.) Ching 10 parts, Radix Salviae Miltiorrhizae 14 parts, Folium et Caulis Indigoferae Tinctoriae 12 parts, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 10 parts, Drymoglossum Herba Drymoglossi 10 parts, spends very sweet 13 parts in vain, Herba Portulacae 9 parts, Herba Taraxaci 13 parts, Herba Andrographis 11 parts.Above-mentioned a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis is:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, with stifling 22 minutes of vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, to add concentration be concentration is that 60% alcoholic solution floods 16 hours, then carries out percolation, collects and filters liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak 28 minutes, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, amount of water is 6 times of boiled crude drug quality, big fire is heated to boiling, turns little fire and decocts 36 minutes, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) step (1) (3) made crude drug was pulverized 120 mesh sieves, mix with filter liquid and filtrate of step (2) (4) gained, heating is concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
Model case: xxx, women, 8 years old.Medical history: patient occurred heating paresthesia without obvious inducement before two weeks, body temperature up to 39.2 DEG C, with fear of cold, the symptom such as weak, after taking febrifuge, body temperature declines to some extent, and next day, one enclosed mass appearred in cervical region, there is tenderness sense, smooth surface, without adhesion, goes to see a doctor, check that quantity of leucocyte obviously increases, be diagnosed as lymphadenitis, after using antibiotic therapy, the state of an illness is without being clearly better.
Through this example of people's recommendation gained external plaster application agent, each one pastes, and within two days, changes once, it within ten days, is a course for the treatment of, after patient uses a course for the treatment of, lymph node reduces, and uncomfortable disease is eliminated substantially, continue a course for the treatment of of use, further consultation checks, lymph node and routine blood test recover normal, and patient fully recovers, follow up a case by regular visits in 1 year, do not recur.
embodiment 4treat an external application of Chinese medicine patch for lymphadenitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Alismatis 15 parts, Herba Erigerontis Annui 12 parts, Radix Stephaniae Cepharanthae 10 parts, Radix Platycodonis 16 parts, Folium Hibisci Rosae-Sinensis 16 parts, Lepidogrammitis drymoglossoides (Bak.) Ching 14 parts, Radix Salviae Miltiorrhizae 16 parts, Folium et Caulis Indigoferae Tinctoriae 14 parts, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 15 parts, Drymoglossum Herba Drymoglossi 12 parts, spends very sweet 15 parts in vain, Herba Portulacae 11 parts, Herba Taraxaci 15 parts, Herba Andrographis 13 parts.Above-mentioned a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis is:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, with stifling 30 minutes of vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, to add concentration be concentration is that 70% alcoholic solution floods 20 hours, then carries out percolation, collects and filters liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak 32 minutes, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, amount of water is 7 times of boiled crude drug quality, big fire is heated to boiling, turns little fire and decocts 42 minutes, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) step (1) (3) made crude drug was pulverized 160 mesh sieves, mix with filter liquid and filtrate of step (2) (4) gained, heating is concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
embodiment 5treat an external application of Chinese medicine patch for lymphadenitis, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Alismatis 14 parts, Herba Erigerontis Annui 11 parts, Radix Stephaniae Cepharanthae 9.5 parts, Radix Platycodonis 15 parts, Folium Hibisci Rosae-Sinensis 14 parts, Lepidogrammitis drymoglossoides (Bak.) Ching 12 parts, Radix Salviae Miltiorrhizae 15 parts, Folium et Caulis Indigoferae Tinctoriae 13 parts, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12.5 parts, Drymoglossum Herba Drymoglossi 11 parts, spends very sweet 14 parts in vain, Herba Portulacae 10 parts, Herba Taraxaci 14 parts, Herba Andrographis 12 parts.Above-mentioned a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis is:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, with stifling 26 minutes of vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, to add concentration be concentration is that 65% alcoholic solution floods 18 hours, then carries out percolation, collects and filters liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak 30 minutes, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, amount of water is 6.5 times of boiled crude drug quality, big fire is heated to boiling, turns little fire and decocts 39 minutes, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) step (1) (3) made crude drug was pulverized 140 mesh sieves, mix with filter liquid and filtrate of step (2) (4) gained, heating is concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Alismatis: nature and flavor with return through: sweet, light, cold.Return kidney, urinary bladder channel.There is promoting diuresis to eliminate damp pathogen, expel the heat-evil, change effect of turbid blood fat reducing.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.
Herba Erigerontis Annui: base is former: be the herb of feverfew Herba Erigerontis Annui.Nature and flavor with return through: property is sweet, bitter, cool, returns stomach, large intestine channel.There is the antidiarrheal that helps digestion, heat-clearing and toxic substances removing, effect of preventing the attack (or recurrence) of malaria.Cure mainly dyspepsia, gastroenteritis, gingivitis, malaria, venom.
Radix Stephaniae Cepharanthae: base is former: be the tuber of menispermaceous plants Radix Stephaniae Cepharanthae.Nature and flavor: toil; Cool; Mild toxicity.Gui Jing: spleen; Lung; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Wind-expelling pain-stopping; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Pyretic toxicity carbuncle; Rheumatic arthralgia; Stomachache; Dysentery; Spit blood; Epistaxis; Traumatic hemorrhage.
Radix Platycodonis: nature and flavor: bitter, pungent is flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Folium Hibisci Rosae-Sinensis: base is former: be the leaf of Malvaceae plant Hibiscus rosasinensis.Nature and flavor: sweet in the mouth; Light; Property is put down.Gui Jing: the heart; Liver Channel.Function cures mainly: the diarrhea of heat type that disappears wets; Removing toxic substances.Main leucorrhea; Stranguria; Furuncle swelling toxin; Parotitis; Mastitis; Lymphadenitis.
Lepidogrammitis drymoglossoides (Bak.) Ching: base is former: be the herb of Plants of Polypodiaceae Drymoglossum Herba Drymoglossi.Chemical analysis: herb is containing flavone, alkaloid, sterol, aminoacid, sugar etc.Nature and flavor: bitter; Flat.Gui Jing: liver; Stomach; Urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing; Relieving stranguria by diuresis; Repercussive; Hemostasis.Main infantile hyperpyrexia; Mumps; Acute toothache; Mass in the abdomen; Tympanites; Stranguria with turbid discharge; Spitting of blood; Spit blood; Epistaxis; Have blood in stool; Hematuria; Metrorrhagia; Traumatic hemorrhage; Furuncle carbuncle; Scrofula; Traumatic injury; Hypertension; Rhinitis; Tracheitis.
Radix Salviae Miltiorrhizae: nature and flavor are bitter, cold nature.Energy blood circulation promoting and blood stasis dispelling, removing heat from blood, calms the nerves.Enter the heart, spleen two warp.According to " book on Chinese herbal medicine is looked for the truth ": Radix Salviae Miltiorrhizae has the effect into percardium removing blood stasis with potent drugs.Modern medicine study confirms, its energy coronary artery dilator, increases coronary flow, improve myocardial ischemia, infraction and cardiac function, regulate the rhythm of the heart, and can expand peripheral blood vessel, improve microcirculation; Body's hypoxia tolerance can be improved; There is anticoagulation, promote fibrinolytic, suppress platelet aggregation, the effect of inhibition thrombosis; Can blood fat be reduced, suppress coronary atherosclerosis to be formed; The convalescent period of erythrocyte and hematochrome can be shortened, Reticulocyte is increased, the reparation organized can be promoted, accelerate the healing of fracture; Nervus centralis is had to have inhibitory action; There is antitumor action; Energy enhancing human body immunity function; Blood glucose can be reduced; Inhibitory action is had to various bacteria such as tubercule bacillus.
Folium et Caulis Indigoferae Tinctoriae: base is former: be leaf and the stem of leguminous plant Folium et Caulis Indigoferae Tinctoriae.Nature and flavor: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, and blood stasis removing stops blooding.Control encephalitis B, parotitis, conjunctival congestion, skin ulcer swells, and spits blood.
Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae): base is former: be the rhizome of nephrolepidaceae plant Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae), leaf or herb.Nature and flavor: sweet; Light; Puckery; Cool.Gui Jing: liver; Kidney; Stomach; Small intestine meridian.Function cures mainly: clearing away heat-damp and promoting diuresis; Treating stranguria cough-relieving; Subduing swelling and detoxicating.Main cold, fever; Cough due to lung-heat; Jaundice; Stranguria with turbid discharge; Difficulty and pain in micturition; Have loose bowels; Dysentery; Leukorrhagia; Hernia; Acute mastitis; Scrofula; Scald; Knife injury; Lymphadenitis; Tinea corporis; Orchitis.
Drymoglossum Herba Drymoglossi: base is former: be the herb of Plants of Polypodiaceae Drymoglossum Herba Drymoglossi.Nature and flavor: sweet; Light; Micro-cool.Gui Jing: liver; Lung meridian.Function cures mainly: heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds; Hemostasis.Main jaundice due to damp-heat; Conjunctival congestion and swelling pain; Suppurative otitis media; Parotitis; Lymphadenitis; Mange; Traumatic injury.
Spend in vain very sweet: base is former: be the herb of labiate dracocephalum heterophyllum.Nature and flavor: bitter, acrid, cold.Function cures mainly: cough-relieving, clearing away liver-fire, Disperse hepatic depression.For bronchitis, hypertension, thyromegaly, tuberculous lymphadenitis, lymphadenitis; External treating dental ulcer.
Herba Portulacae: nature and flavor with return through acid, cold.Return liver, large intestine channel.Function with cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Herba Taraxaci: nature and flavor with return through: bitter, sweet, cold.Return liver, stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.Nature and flavor: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." return through: " Quanzhou book on Chinese herbal medicine ": " enters the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.Pharmacological action: 1. antibacterial action 2. antivirus action 3. other effects.
test example 1a kind of clinical practice for the treatment of the external application of Chinese medicine patch (embodiment 5) of lymphadenitis of gained of the present invention:
Choose crowd: in February ,-2015 in March, 2013, according to medical case history, be diagnosed as patient 381 example of lymphadenitis five hospitals' screenings, age 8-58 year, 36.2 ± 1.4 years old mean age, the course of disease more than 4 days, wherein male patient 198 example, female patient 183 example.Exclusion standard: the acute lymphadenitis 1. having formed abscess; 2. severe cardiac, brain, liver, kidney diaseases, malignant tumor patient is had; 3. gestation and women breast-feeding their children; 4. due to lymphadenectasis that tuberculosis, tumor etc. cause; 5. severe infection and multiple infection person, use other antibacterials person.
Before test, patient is divided into two groups at random, experimental group 236 example and matched group 145 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, and each one pastes, and within two days, changes once, within ten days, is a course for the treatment of; Matched group takes other conventional medicines (anti inflammatory blood quickening ball, SANHUANG PIAN, XIHUANG WAN or zijin troche etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) fully recovers: clinical symptom disappearance, and lump dissipates, and routine blood test and body temperature all recover normal; (2) effective: clinical symptom disappearance, lump obviously reduces, and leukocyte and body temperature reduce; (3) invalid: clinical symptoms without improvement, lump without reducing, routine blood test and body temperature unchanged.
Clinical effectiveness: after the treatment of two courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the recovery from illness patient of experimental group is 176 examples, effective patient is 55 examples, and effective percentage is 23.3%, and total effective rate is 97.9%, and the patient of matched group recovery from illness is 86 examples, effective patient is 33 examples, and total effective rate 82.1%, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The Chinese medicine used in the present invention, comprises the Rhizoma Alismatis of promoting diuresis to eliminate damp pathogen, the Herba Erigerontis Annui of heat-clearing and toxic substances removing, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymotaenium miyoshianum (Mak.) Mak. and Herba Andrographis, the Radix Stephaniae Cepharanthae of wind-expelling pain-stopping, the Radix Platycodonis of lung qi dispersing sore-throat relieving, the Folium Hibisci Rosae-Sinensis that the diarrhea of heat type that disappears is wet, the Radix Salviae Miltiorrhizae of anti-inflammation, the Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) of detumescence dampness removing, the Drymoglossum Herba Drymoglossi of dispersing swelling and dissipating binds, Herba Taraxaci, spending in vain that liver heat removing is reduced internal heat is very sweet, the Herba Portulacae of cooling blood for hemostasis, multiple medical material synergism, plays effect of heat-clearing and toxic substances removing, anti-inflammation altogether, for lymphadenitis, evident in efficacy.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat an external application of Chinese medicine patch for lymphadenitis, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Alismatis 12-16; Herba Erigerontis Annui 9-13; Radix Stephaniae Cepharanthae 7-12; Radix Platycodonis 13-17; Folium Hibisci Rosae-Sinensis 10-18; Lepidogrammitis drymoglossoides (Bak.) Ching 8-16; Radix Salviae Miltiorrhizae 12-18; Folium et Caulis Indigoferae Tinctoriae 10-16; Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 8-17; Drymoglossum Herba Drymoglossi 9-13; Spend very sweet 11-17 in vain; Herba Portulacae 8-12; Herba Taraxaci 12-16; Herba Andrographis 10-14.
2. a kind of external application of Chinese medicine patch for the treatment of lymphadenitis as claimed in claim 1, is characterized in that, Rhizoma Alismatis 13-15; Herba Erigerontis Annui 10-12; Radix Stephaniae Cepharanthae 9-10; Radix Platycodonis 14-16; Folium Hibisci Rosae-Sinensis 12-16; Lepidogrammitis drymoglossoides (Bak.) Ching 10-14; Radix Salviae Miltiorrhizae 14-16; Folium et Caulis Indigoferae Tinctoriae 12-14; Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 10-15; Drymoglossum Herba Drymoglossi 10-12; Spend very sweet 13-15 in vain; Herba Portulacae 9-11; Herba Taraxaci 13-15; Herba Andrographis 11-13.
3. a kind of external application of Chinese medicine patch for the treatment of lymphadenitis as claimed in claim 1, is characterized in that, Rhizoma Alismatis 14; Herba Erigerontis Annui 11; Radix Stephaniae Cepharanthae 9.5; Radix Platycodonis 15; Folium Hibisci Rosae-Sinensis 14; Lepidogrammitis drymoglossoides (Bak.) Ching 12; Radix Salviae Miltiorrhizae 15; Folium et Caulis Indigoferae Tinctoriae 13; Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12.5; Drymoglossum Herba Drymoglossi 11; Spend very sweet 14 in vain; Herba Portulacae 10; Herba Taraxaci 14; Herba Andrographis 12.
4. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Herba Erigerontis Annui, Lepidogrammitis drymoglossoides (Bak.) Ching, Drymoglossum Herba Drymoglossi, spend very sweet and Herba Portulacae in vain and pick up clean impurity, be placed in steamer, fumigate with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) Folium Hibisci Rosae-Sinensis and Herba Andrographis cleaned and smash to pieces, it is (preferred: dipping 16-20 hour to add alcoholic solution dipping 14-22 hour; Be more preferably: flood 18 hours), then carry out percolation, collect and filter liquid and reclaim ethanol;
(3) get Rhizoma Alismatis, Radix Stephaniae Cepharanthae and Radix Salviae Miltiorrhizae removing impurity, put into saline and soak, take out and be placed in pot, water proof heats, and steams to well-done, section, spray rice wine, and be placed in baking box and dry, taking-up cools;
(4) Radix Platycodonis, Folium et Caulis Indigoferae Tinctoriae, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) and Herba Taraxaci are picked up clean impurity, be placed in marmite, decoct with water, big fire is heated to boiling, and turn little fire and decoct, filter after closing fire, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) made to step (1) (3) crude drug is pulverized, mix with filter liquid and filtrate of step (2) (4) gained, heat and be concentrated into clear paste, add adjuvant, uniform application, on cotton, cuts into 8*12cm size, be affixed on pressure sensitive adhesive, obtain external application of Chinese medicine patch.
5. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as claimed in claim 4, is characterized in that, step (1) with vinegar fumigate 18-34 minute (preferred: to fumigate 22-30 minute with vinegar; Be more preferably: fumigate 26 minutes with vinegar).
6. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as claimed in claim 4, it is characterized in that, the concentration of step (2) ethanol is that 50%-80%(is preferred: the concentration of ethanol is 60%-70%; Be more preferably: the concentration of ethanol is 65%).
7. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as claimed in claim 4, is characterized in that, soak in step (3) saline 24-36 minute (preferred: in saline, to soak 28-32 minute; Be more preferably: soak 30 minutes in saline).
8. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as claimed in claim 4, is characterized in that, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
9. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as claimed in claim 4, is characterized in that, step (4) turn little fire decoct 32-46 minute (preferred: to turn little fire and decoct 36-42 minute; Be more preferably: turn little fire and decoct 39 minutes).
10. a kind of preparation method for the treatment of the external application of Chinese medicine patch of lymphadenitis as claimed in claim 4, is characterized in that, it is (preferred: to pulverize 120-160 mesh sieve that step (5) pulverized 100-180 mesh sieve; Be more preferably: pulverized 140 mesh sieves).
CN201510239305.2A 2015-05-13 2015-05-13 Traditional Chinese medicine externally applied patch for treating lymphnoditis and preparation method thereof Pending CN104784388A (en)

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