CN105169113A - Traditional Chinese medicine oral liquid for treating urticaria and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid for treating urticaria and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine oral liquid for treating urticaria and a preparation method thereof. The traditional Chinese medicine oral liquid is prepared from the following raw materials in parts by weight: 28-32 parts of flos lonicerae, 28-32 parts of belvedere fruits, 18-22 parts of radix arnebiae seu lithospermi, 28-32 parts of dandelion, 18-32 parts of cortex dictamni, 38-42 parts of buffla hom wire, 13-17 parts of wild chrysanthemum flowers, 18-22 parts of lumbricus, 28-32 parts of semen coicis, 10-14 parts of radix geutianae, 6-10 parts of pillis ophidiae, 8-12 parts of folia perillae acutae, 13-17 parts of herba schizonepetae, 28-32 parts of tuber fleeceflower stems, and 5-9 parts of radix glycyrrhizae. The traditional Chinese medicine oral liquid disclosed by the invention has the effects of clearing away heat and eliminating dampeness, strengthening the body resistance to eliminate pathogenic factors, and dispelling wind and arresting itching; and the traditional Chinese medicine oral liquid is a traditional Chinese medicine composition which is safe and reliable and high in effective component utilization rate, has no toxic or side effect, and takes effect quickly.
Description
Technical field
The present invention relates to a kind of Chinese medicine oral liquid for the treatment of urticaria, belong to the field of Chinese medicines.
Background technology
Urticaria refers to and causes skin by various factors, mucosa, there is temporary inflammatory hyperemia and edema in tissue in blood vessel, the course of disease is called urticaria more than 6 weeks persons, the cause of disease is often uncertain, clinical manifestation is that patient is sporadically at trunk, face or extremity generation welt and speckle, show effect from every day for several times to a few days once not etc., clinical manifestation is before rubella wheal occurs, local skin is itched or is had tingling, there is erythra rapidly, General Symptoms is there is in some patients in rubella wheal number hour or 1-2 day, as appetite is bad, general malaise, headache or heating, rubella wheal shows as flat rubescent or glaucous edemous speckle, there is blush at edge, rubella wheal can claim ring-type urticaria ringwise, several adjacent ring-like lesion can connect or merge and form map shape, can be described as figure urticaria, have in rubella wheal during vesicle and be called vesicle urticaria, rubella wheal is everlasting Lock-out in a few hours or 1-2 day, other positions have again new skin lesion to occur successively, rubella wheal has disappeared to be in 24 hours and new infringement has no longer occurred, after rubella wheal disappears, skin recovers normal, size and the number of rubella wheal are indefinite, the skin at any position can be appeared at, mucosa, rubella wheal causes play to itch, acupuncture or burning sensation, each one degree is different, headache is had time serious, the General Symptomies such as heating, especially acute urticaria patient is heatable reaches about 40 DEG C, blood pressure can reduce even generation and faint and shock, the rubella wheal that most patient is only itched and without other symptoms, the course of disease of rubella wheal is indefinite, erythra is for several times there is in what have within one day, outbreak is stopped after a few days or 1-2 thoughtful several weeks, be called acute urticaria, there is erythra in many patients everyday, or occur time and again by spells or increase the weight of, alleviate or disappear, can for several months or several years, be called urticaria and specific type urticaria, the western medical treatment Main Means taked this disease at present takes antibiotic, but western medicine is temporary transient symptom management mostly, and it is harmful unhelpful to take too many antibiotic, because abuse of antibiotics may cause bottleneck throat normal flora to be lacked of proper care, and resistance can be caused to strengthen, immune function of human body goes down, cause Relapse rate difficulty more.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of urticaria, it has effect of clearing away heat and eliminating dampness, strengthening vital QI to eliminate pathogenic factors, dispelling wind for relieving itching.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine oral liquid for urticaria, be made up of following raw material: Flos Lonicerae 28-32 part, Fructus Kochiae 28-32 part, Radix Arnebiae (Radix Lithospermi) 18-22 part, Herba Taraxaci 28-32 part, Cortex Dictamni 18-32 part, Cornu Bubali silk 38-42 part, Flos Chrysanthemi Indici 13-17 part, Pheretima 18-22 part, Semen Coicis 28-32 part, Radix Gentianae 10-14 part, Periostracum Serpentis 6-10 part, Folium Perillae 8-12 part, Herba Schizonepetae 13-17 part, Caulis Polygoni Multiflori 28-32 part, Radix Glycyrrhizae 5-9 part.
Preferably, each parts by weight of raw materials is: Flos Lonicerae 30 parts, the Fructus Kochiae 30 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, Herba Taraxaci 30 parts, Cortex Dictamni 30 parts, Cornu Bubali silk 40 parts, Flos Chrysanthemi Indici 15 parts, Pheretima 20 parts, Semen Coicis 30 parts, Radix Gentianae 12 parts, Periostracum Serpentis 8 parts, Folium Perillae 10 parts, Herba Schizonepetae 15 parts, Caulis Polygoni Multiflori 30 parts, 7 parts, Radix Glycyrrhizae.
Pharmacological action:
Flos Lonicerae: nature and flavor with return through: sweet, cold; Return lung, the heart, stomach warp, function with cure mainly: heat-clearing and toxic substances removing, wind-heat dissipating; For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
The Fructus Kochiae: nature and flavor with return through: pungent, bitter, cold; Return kidney, urinary bladder channel, function with cure mainly: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching; For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Arnebiae (Radix Lithospermi): nature and flavor with return through: sweet, salty, cold; GUIXIN, Liver Channel, function with cure mainly: removing heat from blood, invigorate blood circulation, removing toxic substances rash; Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Herba Taraxaci: nature and flavor with return through: bitter, sweet, cold; Return liver, stomach warp, function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Cortex Dictamni: nature and flavor hardship is salty, cold; Gui Jing enters spleen, stomach warp; Function cures mainly: dispel the wind, dampness, heat clearing away, removing toxic substances; Control wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia, jaundice.
Cornu Bubali: nature and flavor are bitter, cold; Return through GUIXIN, Liver Channel; Effect: clearing away heat and cooling blood, removing toxic substances, arresting convulsion; Cure mainly: for the high heat of epidemic febrile disease, unconsciousness and delirium, sends out speckle dermexanthesis, hematemesis and epistaxis, infantile convulsion, demented.
Flos Chrysanthemi Indici: nature and flavor with return through: bitter, pungent, be slightly cold; Return liver, heart channel, function with cure mainly: heat-clearing and toxic substances removing; For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.
Pheretima: nature and flavor with return through: salty, cold; Return liver, spleen, urinary bladder channel, function with cure mainly: heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis; For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Semen Coicis: nature and flavor with return through: sweet, light, cool; Return spleen, stomach, lung meridian, function with cure mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, heat clearing away row dense; For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
Radix Gentianae: nature and flavor are bitter, cold; Gui Jing: return liver, gallbladder meridian; Function cures mainly: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire; For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
Periostracum Serpentis: nature and flavor with return through: salty, sweet, flat; Return Liver Channel, function with cure mainly: dispel the wind, arresting convulsion, removing toxic substances, nebula removing; For infantile convulsion, tic spasm, cataracta, sore throat, furuncle swells, skin pruritus.
Folium Perillae: nature and flavor with return through: pungent, temperature; Return lung, spleen channel, function with cure mainly: induce sweat cold expelling, relieving QI stagnancy in the stomach; For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.
Herba Schizonepetae: nature and flavor with return through: pungent, tepor; Return lung, Liver Channel, function with cure mainly: induce sweat loose wind, rash; For flu, headache, measles, rubella, skin infection from the beginning of; Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Caulis Polygoni Multiflori: meridian distribution of property and flavor: sweet micro-hardship is flat; Nourish heart, calm the nerves, dredging collateral, dispel the wind, cure mainly: control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies; External: alone outer decocting is washed, treating skin wind skin ulcer prurigo, can receive effect of dispelling wind for relieving itching.
Radix Glycyrrhizae: nature and flavor with return through: sweet, flat; GUIXIN, lung, spleen, stomach warp, function with cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Another technical problem to be solved by this invention is to provide a kind of preparation method preparing above-mentioned Chinese medicine oral liquid.
Another technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a preparation method for the Chinese medicine oral liquid of urticaria, be prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
Preferably, a kind of preparation method for the treatment of the Chinese medicine oral liquid of urticaria, is prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 18000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 80% is added by volume, leave standstill 48 hours, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size of the filter membrane of described ultrafilter is 40nm, and the pressure limit crossed in filter fly is 0.3MPa, and the scope of the crossflow velocity in filter process is 3.5m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, when being evaporated to 60 DEG C in receiver, the extractum of relative density 1.10, obtains extractum, for subsequent use;
(6) by gained clear paste sodium hydroxide solution adjust ph to 7.0 in step (5), then embedding is in clean vial, and steam sterilization 35min sterilizing under 100 DEG C of conditions after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
Beneficial effect: the present invention has effect of clearing away heat and eliminating dampness, strengthening vital QI to eliminate pathogenic factors, dispelling wind for relieving itching, be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.
The present invention adopts pure Chinese medicine to be raw material, according to pathogenic factor and the Clinical symptoms of urticaria, under instruction of Chinese Medicine theory, carry out prescription be prepared from the basis not being raw-material activity, show through clinical efficacy, this medicine has definite curative effect to urticaria, is the ideal treatment medication of a kind of urticaria patient.
Model case
Case 1: Mr. Xie, 26 years old, medical history: skin pruritus, played one piece of block erythema, has March, and card belongs to noxious dampness type, examined as urticaria, took a course for the treatment of of Drug therapy of the present invention, recovered, follow up a case by regular visits to 1 year without recurrence.
Case 2: Mr. Tao, 20 years old, medical history: rash block appears in whole body, pruritus, recurrent exerbation more than a year, once took Western medicine, curative effect is not good enough, time medical, health still has the red rash block do not moved back, pruritus, fear of cold, weak, take a course for the treatment of of Drug therapy of the present invention, after treatment, symptom obviously reduces, and after taking two courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 3: Mrs Ye, 23 years old, medical history: suffer from urticaria 1 year, every day gos out, and suddenly plays welt, differ in size, a few hours side moves back, and takes a course for the treatment of of Drug therapy of the present invention, after treatment, symptom obviously reduces, and after taking two courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 4: Mrs Lu, 35 years old, medical history: patient suffers from urticaria with more than 3 years, Chinese and western drugs is taken many, but curative effect is always undesirable, few time many during welt, recurrent exerbation, takes a course for the treatment of of Drug therapy of the present invention, and after treatment, symptom obviously reduces, after taking two courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 5: Mrs Yuan, 50 years old, medical history: suffer from urticaria more than a year, took repeatedly Chinese medicine, curative effect is bad, few time many during welt, the recurrent exerbation several months, take a course for the treatment of of Drug therapy of the present invention, after treatment, symptom obviously reduces, after taking two courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Case 6: Mrs Wen, 44 years old, medical history: patient main suit is over nearly 3 years, there is welt in whole skin, time disappears when rising, sooner or later more acute, namely alleviate after taking Claritin, recur after drug withdrawal, recently show effect again, very itch, examine as urticaria, take Drug therapy of the present invention course for the treatment of, after treatment, symptom obviously reduces, after taking two courses for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, and follows up a case by regular visits to 1 year without recurrence.
Clinical data
General data: urticaria patient 50 example, man 13 example, female 37 example, age 25-65 year.
Diagnosis basis: (1) break out, sized by skin lesion not etc., the edemous speckle that shape differs, boundary is clear; (2) fall when rising during erythra, violent pruritus, skin lesion appearing without definite location, steps back and leaves no trace; (3) some cases can have abdominal pain diarrhea, or has the disease such as heating, arthralgia.Severe patient can have dyspnea, even causes and suffocates; (4) erythra more or was not repeatedly interrupted an author through more than three months.
Therapeutic Method: take oral liquid of the present invention, every day 2 times, each 40ml 7 days is a course for the treatment of, and treatments period is avoided cold and uncooked food the thing of pungent stimulation.
Criterion of therapeutical effect: (1) fully recovers: after medication, speckle disappears completely, pruritus disappears, and drug withdrawal is nothing recurrence after one month; (2) effective: after medication, speckle disappears completely, pruritus disappears, and drug withdrawal was recurred after one week; (3) effective: attack times reduces, and pruritus alleviates; (4) invalid: welt, pruritus are for alleviating.
Therapeutic effect: in treatment urticaria patient 50 example, 40 examples of wherein fully recovering, effective 8 examples, effective 2 examples, invalid 0 example, total effective rate is 100%, and toxic and side effects does not occur treatments period.
Detailed description of the invention
Embodiment 1
The present invention treats the preparation of urticaria Chinese medicine oral liquid, and the weight portion of each raw material is: Flos Lonicerae 32 parts, the Fructus Kochiae 32 parts, Radix Arnebiae (Radix Lithospermi) 22 parts, Herba Taraxaci 32 parts, Cortex Dictamni 32 parts, Cornu Bubali silk 42 parts, Flos Chrysanthemi Indici 17 parts, Pheretima 22 parts, Semen Coicis 32 parts, Radix Gentianae 14 parts, Periostracum Serpentis 10 parts, Folium Perillae 12 parts, Herba Schizonepetae 17 parts, Caulis Polygoni Multiflori 32 parts, 9 parts, Radix Glycyrrhizae;
Be prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
Usage: oral, every day 2 times, each 40ml.
Embodiment 2
The present invention treats the preparation of urticaria Chinese medicine oral liquid, and the weight portion of each raw material is: Flos Lonicerae 30 parts, the Fructus Kochiae 30 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, Herba Taraxaci 30 parts, Cortex Dictamni 30 parts, Cornu Bubali silk 40 parts, Flos Chrysanthemi Indici 15 parts, Pheretima 20 parts, Semen Coicis 30 parts, Radix Gentianae 12 parts, Periostracum Serpentis 8 parts, Folium Perillae 10 parts, Herba Schizonepetae 15 parts, Caulis Polygoni Multiflori 30 parts, 7 parts, Radix Glycyrrhizae;
Be prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
Usage: oral, every day 2 times, each 40ml.
Embodiment 3
The present invention treats the preparation of urticaria Chinese medicine oral liquid, and the weight portion of each raw material is: Flos Lonicerae 28 parts, the Fructus Kochiae 28 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Taraxaci 28 parts, Cortex Dictamni 28 parts, Cornu Bubali silk 38 parts, Flos Chrysanthemi Indici 13 parts, Pheretima 18 parts, Semen Coicis 28 parts, Radix Gentianae 10 parts, Periostracum Serpentis 6 parts, Folium Perillae 8 parts, Herba Schizonepetae 13 parts, Caulis Polygoni Multiflori 28 parts, 5 parts, Radix Glycyrrhizae;
Be prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
Usage: oral, every day 2 times, each 40ml.
Claims (6)
1. treat a Chinese medicine oral liquid for urticaria, it is characterized in that: be made up of following raw material: Flos Lonicerae 28-32 part, Fructus Kochiae 28-32 part, Radix Arnebiae (Radix Lithospermi) 18-22 part, Herba Taraxaci 28-32 part, Cortex Dictamni 18-32 part, Cornu Bubali silk 38-42 part, Flos Chrysanthemi Indici 13-17 part, Pheretima 18-22 part, Semen Coicis 28-32 part, Radix Gentianae 10-14 part, Periostracum Serpentis 6-10 part, Folium Perillae 8-12 part, Herba Schizonepetae 13-17 part, Caulis Polygoni Multiflori 28-32 part, Radix Glycyrrhizae 5-9 part.
2. a kind of Chinese medicine oral liquid for the treatment of urticaria according to claim 1, is characterized in that: the weight portion of each raw material is: Flos Lonicerae 30 parts, the Fructus Kochiae 30 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, Herba Taraxaci 30 parts, Cortex Dictamni 30 parts, Cornu Bubali silk 40 parts, Flos Chrysanthemi Indici 15 parts, Pheretima 20 parts, Semen Coicis 30 parts, Radix Gentianae 12 parts, Periostracum Serpentis 8 parts, Folium Perillae 10 parts, Herba Schizonepetae 15 parts, Caulis Polygoni Multiflori 30 parts, 7 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine oral liquid for the treatment of urticaria according to claim 1, is characterized in that: the weight portion of each raw material is: Flos Lonicerae 32 parts, the Fructus Kochiae 32 parts, Radix Arnebiae (Radix Lithospermi) 22 parts, Herba Taraxaci 32 parts, Cortex Dictamni 32 parts, Cornu Bubali silk 42 parts, Flos Chrysanthemi Indici 17 parts, Pheretima 22 parts, Semen Coicis 32 parts, Radix Gentianae 14 parts, Periostracum Serpentis 10 parts, Folium Perillae 12 parts, Herba Schizonepetae 17 parts, Caulis Polygoni Multiflori 32 parts, 9 parts, Radix Glycyrrhizae.
4. a kind of Chinese medicine oral liquid for the treatment of urticaria according to claim 1, is characterized in that: the weight portion of each raw material is: Flos Lonicerae 28 parts, the Fructus Kochiae 28 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, Herba Taraxaci 28 parts, Cortex Dictamni 28 parts, Cornu Bubali silk 38 parts, Flos Chrysanthemi Indici 13 parts, Pheretima 18 parts, Semen Coicis 28 parts, Radix Gentianae 10 parts, Periostracum Serpentis 6 parts, Folium Perillae 8 parts, Herba Schizonepetae 13 parts, Caulis Polygoni Multiflori 28 parts, 5 parts, Radix Glycyrrhizae.
5. a kind of preparation method for the treatment of the Chinese medicine oral liquid of urticaria according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
6. a kind of preparation method for the treatment of the Chinese medicine oral liquid of urticaria according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) the raw material Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Herba Taraxaci, Cortex Dictamni, Cornu Bubali silk, Pheretima, Semen Coicis, Radix Gentianae, Periostracum Serpentis, Herba Schizonepetae, Caulis Polygoni Multiflori, Radix Glycyrrhizae cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Flos Lonicerae, Flos Chrysanthemi Indici, Folium Perillae cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 18000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 80% is added by volume, leave standstill 48 hours, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size of the filter membrane of described ultrafilter is 40nm, and the pressure limit crossed in filter fly is 0.3MPa, and the scope of the crossflow velocity in filter process is 3.5m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, when being evaporated to 60 DEG C in receiver, the extractum of relative density 1.10, obtains extractum, for subsequent use;
(6) by gained clear paste sodium hydroxide solution adjust ph to 7.0 in step (5), then embedding is in clean vial, and steam sterilization 35min sterilizing under 100 DEG C of conditions after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of urticaria.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018811A (en) * | 2009-09-09 | 2011-04-20 | 马黎晓 | Chinese materia medica preparation for treating urticaria |
| CN104173843A (en) * | 2014-09-15 | 2014-12-03 | 韩世荣 | Traditional Chinese medicine pill for treating urticaria |
| CN104758729A (en) * | 2015-04-26 | 2015-07-08 | 王伟伟 | Traditional Chinese medicine composition for treating chronic urticaria |
| CN104997904A (en) * | 2015-07-22 | 2015-10-28 | 江苏宝晨泽生物技术有限公司 | Pressure urticaria treating agent |
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2015
- 2015-11-10 CN CN201510759265.4A patent/CN105169113A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018811A (en) * | 2009-09-09 | 2011-04-20 | 马黎晓 | Chinese materia medica preparation for treating urticaria |
| CN104173843A (en) * | 2014-09-15 | 2014-12-03 | 韩世荣 | Traditional Chinese medicine pill for treating urticaria |
| CN104758729A (en) * | 2015-04-26 | 2015-07-08 | 王伟伟 | Traditional Chinese medicine composition for treating chronic urticaria |
| CN104997904A (en) * | 2015-07-22 | 2015-10-28 | 江苏宝晨泽生物技术有限公司 | Pressure urticaria treating agent |
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Application publication date: 20151223 |