CN107929529A - A kind of endo-medicine for treating recurrent oral ulceration and preparation method thereof - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of endo-medicine for treating recurrent oral ulceration according to the understanding mechanism of Chinese traditional treatment recurrent oral ulceration, each component and its mass parts ratio of the medicine are as follows：3~6g of the coptis, 15~65g of gypsum, 10~16g of blumea, 3~10g of radix scutellariae, 6~15g of olive, 8~16g of pueraria lobata, 15~35g of bastardtoadflaxlike swallowwort herb and fruit, 3~12g of the dried immature fruit of citron orange, 10~16g of japanese rose root, 3~12g of radix glycyrrhizae, 6~10g of farges fir cone, 3~9g of the tuber of pinellia, 12~35g of prepared rhizome of rehmannia, 15~28g of whorledleaf solomonseal rhizome, 6~16g of Radix Paeoniae Alba, 3~12g of radix bupleuri；Medicine provided by the invention is a good Chinese prescription.

Description

A kind of endo-medicine for treating recurrent oral ulceration and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese, and in particular to and it is a kind of to treat for oral administration of recurrent oral ulceration, particularly supply The field of the endo-medicine that Blood of Patients with Recurrent Oral uses and preparation method thereof.

Background technology

Doctor thinks：Recurrent aphthous ulcer（recurrent oral ulcer）Also known as recurrent aphthous ulcer （recurrent aphthae）, be most common ulcer diseases in oral mucosal disease, the cause of disease is complicated, more with it is immune, hereditary, Systemic disease, infection, environment（Psychology, life, work, social environment）It is related etc. factor.Illness rate is generally recognized in crowd For more than 10%, men and women, old and young can be betided, with young and middle-aged most common.Recurrent oral ulceration has self limiting, can with self-healing, Any position of mucous membrane of mouth can be betided, common with lip, cheek, tongue, severe patient can involve pharyngeal mucous membrane.Many patients with The extension of the course of disease, ulcer area increase, number increases, and pain aggravates, and healing stage extends, and interval shortening etc., influences to feed With speak.

Clinical manifestation：

1. minor aphtha：It is sensitive or the congested area of needle point sample size occur from the beginning of lesion, formed in a short time diameter 2~ 4mm, circular or ellipse, the shallow aphtha of clear border.Center micro-pits, surface are covered with one layer of faint yellow pseudomembrane, ulcer week It is in blush shape to enclose mucous membrane hyperemia, its substrate is laid one's hand on not hard.Ulcer number is generally 2~3.Ulcer has more violent burning after being formed Cusalgia, especially with obvious at the tip of the tongue.When contacting food excitatory more very.Generally without constitutional symptom.

2. rash sample aphtha：Also known as stomatitis type aphtha.This type is except ulcer is small, number is more（Up to 20~30）Outside, it is remaining with it is light The performance of type aphtha is similar.For Sucralfate widely distributed, mucous membrane is congested obvious.Have acutely and with headache, fever, regional nodes The symptoms such as enlargement.

3. periglandular aphtha：Also known as Periadenitis mucous membrane periadenitis or huge aphtha, are various middle most serious One type.Ulcer often single generation, 2 or more than 2 persons it is rare.Lip inner side and bicker area mucous membrane are apt to occur in, can also be occurred in tongue palate The positions such as bow, soft palate.From the beginning of when ulcer it is identical with minor aphtha, but its diameter is gradually extended to 1~2cm, and to Deep Development To mucous membrane gland.Ulcer can be aubergine, and edge is irregular, is swelled in flap, concavity, and shape is like " crater ".Bottom is uneven, micro- Firmly, in brief summary nodular.Blush is obvious around ulcer.Part has severe pain and can be with whole bodies such as regional glandular enlargement, fevers Symptom.The course of disease is often more than more than the moon, and elder was up to 1 year.Scar is left more afterwards, and severe patient can form tissue defect or deformity.

So, it is art technology with regard to how to find a kind of Chinese medicine composition that can effectively treat recurrent oral ulceration The problem of personnel are urgently to be resolved.

The content of the invention

With the continuous development of China's traditional Chinese medicine, on treatment recurrent oral ulceration, people gradually appreciate The advantages of Chinese traditional treatment recurrent oral ulceration, and good effect, advantage, the pin such as quick, toxic side effect is small over the course for the treatment of To the present situation of existing western medical treatment recurrent oral ulceration, treat recurrent oral the purpose of the invention is to provide one kind and burst The endo-medicine of ulcer, to solve the problems, such as that Blood of Patients with Recurrent Oral is got well early.The medicine is with common Chinese medicine For raw material, by selecting rational medicine and mass parts ratio, above-mentioned recurrent oral ulceration can be effectively treated.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：One kind is provided and treats recurrent oral Endo-medicine of ulcer and preparation method thereof, it is characterised in that each component and mass parts of the medicine are than as follows：

3~6g of the coptis, 15~65g of gypsum, 10~16g of blumea, 3~10g of radix scutellariae, 6~15g of olive, 8~16g of pueraria lobata, the tip 15~35g of melon, 3~12g of the dried immature fruit of citron orange, 10~16g of japanese rose root, 3~12g of radix glycyrrhizae, 6~10g of farges fir cone, 3~9g of the tuber of pinellia, prepared rhizome of rehmannia 12 ~35g, 15~28g of whorledleaf solomonseal rhizome, 6~16g of Radix Paeoniae Alba, 3~12g of radix bupleuri.

A kind of endo-medicine for treating recurrent oral ulceration and preparation method thereof, it is characterised in that the medicine it is each A component and mass parts are than as follows：

3.5~5.5g of the coptis, 18~56g of gypsum, 11~14g of blumea, 5~8g of radix scutellariae, 7~13g of olive, 9~14g of pueraria lobata, 18~31g of bastardtoadflaxlike swallowwort herb and fruit, 5~11g of the dried immature fruit of citron orange, 11~15g of japanese rose root, 5~11g of radix glycyrrhizae, 7~9g of farges fir cone, 4~8g of the tuber of pinellia, cultivated land 13~31g of Huang, 16~25g of whorledleaf solomonseal rhizome, 7~14g of Radix Paeoniae Alba, 5~11g of radix bupleuri.

A kind of endo-medicine for treating recurrent oral ulceration and preparation method thereof, it is characterised in that the medicine it is each A component and mass parts are than as follows：

Coptis 5g, gypsum 50g, blumea 13g, radix scutellariae 7g, olive 12g, pueraria lobata 13g, bastardtoadflaxlike swallowwort herb and fruit 28g, dried immature fruit of citron orange 10g, japanese rose root 13g, radix glycyrrhizae 10g, farges fir cone 8g, tuber of pinellia 7g, prepared rhizome of rehmannia 28g, whorledleaf solomonseal rhizome 22g, Radix Paeoniae Alba 13g, radix bupleuri 10g.

A kind of endo-medicine for treating recurrent oral ulceration and preparation method thereof, it is characterised in that the described method includes Following steps are prepared：

A, after above-mentioned raw materials Chinese medicine being picked impurity and dust, it is respectively crushed into coarse according to mass parts ratio and decocts a drug wrapped；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and soaks 50min, then again by soaked medicine and soak medicine Clarified solution be put into the lump in marmite, injected medicine 65mm cold boiling water carry out first time high heat decoction, wait decoct arrive 15min When, turn slow boiling and boil 35 min, leaching liquid；2. the tepor boiling water that medicine 60mm was re-injected in the dregs of a decoction carries out second of intense fire Decoct, when 10min is arrived in decoction, turn slow boiling and boil 30 min, leaching liquid；It is condensed into 3. liquid twice is mixed in 50% Liquid 380ml（Milliliter）.

A kind of endo-medicine for treating recurrent oral ulceration and preparation method thereof, it is characterised in that the instructions of taking For：The herb liquid prepared was taken with one day, morning and evening sub-service, dosage 190ml（Milliliter）/ time, take advantage of within one hour before meals and warmly take （Avoid eating raw food and maror）.5 days as a treatment course, 1~3 course for the treatment of of taking medicine, canker sore healing, symptom all disappear, Disease obtains recovery from illness.

Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

The coptis, nature and flavor：It is bitter, cold, there is the effect of purging intense heat, eliminating dampness, removing toxic substances, desinsection, row heat toxin, typhoid fever, excess heat during for treating Vexed, feeling of fullness vomit inverse, bacillary dysentery, heat rush down abdominal pain, lung knot by, spit, be defeated in battle, lower blood, quench one's thirst, infantile malnutrition due to digestive disturbances or intestinalparasites, roundworm disease, pertussis, throat swell Bitterly, pinkeye, aphtha, skin sore, eczema, the burning hot wound of soup；

Gypsum, nature and flavor：It is sweet in flavor, pungent, it is Great Cold, raw to use：Quench the thirst with clearing heat-fire, relieving restlessness, forge use：With expelling pus and promoting granulation, hygroscopic, The effect of hemostasis, for treating the diseases such as the high Sheng of fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, stomach fire, headache, toothache；

Blumea, nature and flavor：It is bitter, cold in nature, there is clearing heat-fire, the efficacy of removing toxicity for detumescence to imitate, for treating cough with lung heat, throat swells Bitterly, aphthae, gastropyretic toothache, Zha ribs, carbuncle sore tumefacting virus；

Radix scutellariae, nature and flavor：It is bitter, cold in nature, there is the effect of clearing heat-fire, eliminating dampness removing toxic substances, hemostasis, tocolysis, for treating lung heat cough Cough, the headache of high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, irascibility, red eye, swell pain, jaundice with damp-heat pathogen, rush down dysentery, heat gonorrhea, hematemesis blood, uterine bleeding, fetal movement with fever, carbuncle Swollen furunculosis illness；

Olive, nature and flavor：It is sweet, sour, puckery, flat, there is removing heat from the lung and relieving sorethroat, the effect of promoting the production of body fluid to quench thirst, detoxify, for treat phlegm blood of coughing, The diseases such as abscess of throat, hot summer weather polydipsia, drunk, fish and crab poisoning；

Pueraria lobata, nature and flavor：It is sweet, pungent, flat, have expelling pathogenic factors from muscles and skin bring down a fever, deliver examine, promote the production of body fluid to quench thirst, Shengyang Zhixie the effect of, for controlling Treat fever caused by exogenous pathogens, rigidity of nape and headache, measles and go out that not smooth, warm disease is thirsty, diabete, diarrhea, dysentery, hypertension, coronary heart disease from the beginning of, rash Deng disease；

Bastardtoadflaxlike swallowwort herb and fruit, nature and flavor：It is sweet in flavor, cool in nature, there is the effect of clear fire of deficiency type, QI invigorating, promote the production of body fluid, is lower newborn, for treating flaring up of deficient fire, pharynx Larynx pain, deficiency of both vital energy and Yin, god it is tired it is forgetful, dysphoria is thirsty, dizzy insomnia, postpartum weakness, hypogalactia；

The dried immature fruit of citron orange, nature and flavor：It is bitter, pungent, sour, be slightly cold, there is the effect of relieving stagnant Qi disperse accumulation, resolving sputum dissipate ruffian, for treating internal stagnation, feeling of fullness Distending pain, weight after rush down dysentery, constipation, the resistance of phlegm stagnant gas, the obstruction of qi in the chest, accumulation of pathogens in chest, visceral organ ptosis；

Japanese rose root, nature and flavor：It is bitter, puckery, cool in nature, have clearing heat and detoxicating, dispelling wind and eliminating dampness, promoting blood circulation for regulating menstruation, astringent sperm contracting urine, disappear bone sticking it Effect, is not cured for treating sore, carbuncle and painful swelling, scald, aphtha, hemorrhoid blood, nosebleed epistaxis, arthralgia, irregular menstruation, dysmenorrhoea, protracted dysentery, loses The diseases such as urine, frequent micturition, leukorrhea, the prolapse of uterus, bone sticking；

Radix glycyrrhizae, nature and flavor：It is sweet, flat, have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription the effect of, use Swell in treatment burnout deficiency of food, the thin face Huang of flesh, palpitation, abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, throat Bitterly, ulcerative carbuncle swelling and pain, infant fetal toxin and medicine, food poisoning；

Farges fir cone, nature and flavor：It is sweet in flavor, puckery, micro-pungent, mild-natured, there is the effect of calming the liver to stop the wind, regulating menstruation, hemostasis, stop-band, for treating height Blood pressure diseases, headache, dizziness, confused and worried, irregular menstruation, uterine bleeding, with inferior disease；

The tuber of pinellia, nature and flavor：It is pungent, warm, it is poisonous, there is the effect of eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, for treating abundant expectoration cough Asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus, it is raw to use controlling outward carbuncle swells subcutaneous nodule, ginger half Summer is chiefly used in stopping nausea and vomiting by lowering the adverse flow of QI；

Prepared rhizome of rehmannia, nature and flavor：Sweet, tepor, has the effect of nourishing yin and supplementing blood, beneficial to spirit and marrow, for treating the deficiency of liver-yin and kidney-yin, waist and knee acid Soft, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, Poliosis；

Whorledleaf solomonseal rhizome, nature and flavor：It is sweet, flat, there is the effect of nourishing liver and kidney, nourishing Yin and promoting production of body fluid, for treat neurasthenia, high blood pressure, Headache, sore-throat, quench one's thirst, mouth parched and tongue scorched；

Radix Paeoniae Alba, nature and flavor：Bitter, acid, be slightly cold, and has the effect of smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating, dizzy for treating headache The disease such as dizzy, hypochondriac pain, abdominal pain, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat；

Radix bupleuri, nature and flavor：Bitter, pungent, cold nature, there is inducing diaphoresis to bring down a fever, soothing liver-qi stagnation, rise the effect of lifting yang-energy, outer for treating Feel fever, fevers and chills alternate, malaria, liver-depressed hypochondrium pain mammary swelling, have a headache a dizzy, irregular menstruation, the rectal prolapse of collapse from qi deficiency, the prolapse of uterus, The diseases such as gastroptosis.

Medicine of the present invention is the principle based on Chinese traditional treatment recurrent oral ulceration, from the disease according to recurrent oral ulceration Reason mechanism and pharmacological action are thought：With regard to recurrent oral ulceration, each raw material herbal medicine efficacy in medicine provided by the present invention is total to Play, have good therapeutic effect to above-mentioned disease.

Embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned recurrent oral ulceration, using the formula The medicine effect of preparation is good, quick, is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the present invention Embodiment be described in further detail：

Embodiment 1：

A kind of endo-medicine for treating recurrent oral ulceration, it is characterised in that each component and mass parts ratio of the medicine It is as follows：

Coptis 5g, gypsum 50g, blumea 13g, radix scutellariae 7g, olive 12g, pueraria lobata 13g, bastardtoadflaxlike swallowwort herb and fruit 28g, dried immature fruit of citron orange 10g, japanese rose root 13g, radix glycyrrhizae 10g, farges fir cone 8g, tuber of pinellia 7g, prepared rhizome of rehmannia 28g, whorledleaf solomonseal rhizome 22g, Radix Paeoniae Alba 13g, radix bupleuri 10g.

Embodiment 2：

A kind of endo-medicine for treating recurrent oral ulceration, it is characterised in that each component and mass parts ratio of the medicine It is as follows：

Coptis 5.5g, gypsum 56g, blumea 14g, radix scutellariae 8g, olive 13g, pueraria lobata 14g, bastardtoadflaxlike swallowwort herb and fruit 31g, dried immature fruit of citron orange 11g, rose Root 15g, radix glycyrrhizae 11g, farges fir cone 9g, tuber of pinellia 8g, prepared rhizome of rehmannia 31g, whorledleaf solomonseal rhizome 25g, Radix Paeoniae Alba 14g, radix bupleuri 11g.

Embodiment 3：

A kind of endo-medicine for treating recurrent oral ulceration, it is characterised in that each component and mass parts ratio of the medicine It is as follows：

Coptis 6g, gypsum 65g, blumea 16g, radix scutellariae 10g, olive 15g, pueraria lobata 16g, bastardtoadflaxlike swallowwort herb and fruit 35g, dried immature fruit of citron orange 12g, japanese rose root 16g, radix glycyrrhizae 12g, farges fir cone 10g, tuber of pinellia 9g, prepared rhizome of rehmannia 35g, whorledleaf solomonseal rhizome 28g, Radix Paeoniae Alba 16g, radix bupleuri 12g.

Model case

Through clinical conditions Blood of Patients with Recurrent Oral totally 1187, the age is 695, only 492 of more than 48 years old For less than 48 years old.1039 to fully recover in 1187 patients, effective 112, invalid 36.Total effective rate is up to 97%.

Claims (3)

1. a kind of endo-medicine for treating recurrent oral ulceration, it is characterised in that each component and its quality of the medicine Part is than as follows：

3~6g of the coptis, 15~65g of gypsum, 10~16g of blumea, 3~10g of radix scutellariae, 6~15g of olive, 8~16g of pueraria lobata, the tip 15~35g of melon, 3~12g of the dried immature fruit of citron orange, 10~16g of japanese rose root, 3~12g of radix glycyrrhizae, 6~10g of farges fir cone, 3~9g of the tuber of pinellia, prepared rhizome of rehmannia 12 ~35g, 15~28g of whorledleaf solomonseal rhizome, 6~16g of Radix Paeoniae Alba, 3~12g of radix bupleuri.

2. it is according to claim 1 treatment recurrent oral ulceration endo-medicine, it is characterised in that the medicine it is each A component and its mass parts are than as follows：

3.5~5.5g of the coptis, 18~56g of gypsum, 11~14g of blumea, 5~8g of radix scutellariae, 7~13g of olive, 9~14g of pueraria lobata, 18~31g of bastardtoadflaxlike swallowwort herb and fruit, 5~11g of the dried immature fruit of citron orange, 11~15g of japanese rose root, 5~11g of radix glycyrrhizae, 7~9g of farges fir cone, 4~8g of the tuber of pinellia, cultivated land 13~31g of Huang, 16~25g of whorledleaf solomonseal rhizome, 7~14g of Radix Paeoniae Alba, 5~11g of radix bupleuri.

3. the endo-medicine of the treatment recurrent oral ulceration according to claim 1 to 2, it is characterised in that the medicine Each component and its mass parts than as follows：

Coptis 5g, gypsum 50g, blumea 13g, radix scutellariae 7g, olive 12g, pueraria lobata 13g, bastardtoadflaxlike swallowwort herb and fruit 28g, dried immature fruit of citron orange 10g, japanese rose root 13g, radix glycyrrhizae 10g, farges fir cone 8g, tuber of pinellia 7g, prepared rhizome of rehmannia 28g, whorledleaf solomonseal rhizome 22g, Radix Paeoniae Alba 13g, radix bupleuri 10g.