CN107823464A - A kind of decoction for oral administration and preparation method for being used to treat recurrent oral ulceration - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of decoction for oral administration for being used to treat recurrent oral ulceration be provided according to the understanding mechanism of Chinese traditional treatment recurrent oral ulceration, each component and its mass parts ratio of the decoction for oral administration are as follows：3~7g of the coptis, 3~15g of golden cypress, 8~16g of dogwood fruit, 3~10g of radix scutellariae, 6~16g of lucid asparagus, 15~65g of gypsum, 12~26g of Sculellaria barbata, 6~15g of the tuber of dwarf lilyturf, 15~35g of reed rhizome, 9~16g of loguat leaf, cape jasmine（Fry）10~26g, 15~30g of the capsule of weeping forsythia, 5~16g of the bletilla striata, 9~16g of radix rehmanniae recen, 6~16g of the stem of noble dendrobium, 15~38g of prepared rhizome of rehmannia, 9~35g of rhizoma imperatae；Medicine provided by the invention is a good Chinese prescription.

Description

A kind of decoction for oral administration and preparation method for being used to treat recurrent oral ulceration

Technical field

The invention belongs to field of traditional Chinese, and in particular to a kind of decoction for oral administration for being used to treat recurrent oral ulceration, The decoction for oral administration particularly used for Blood of Patients with Recurrent Oral and the field of preparation method.

Background technology

According to the relevant information：Recurrent aphthous ulcer（recurrent oral ulcer）Also known as RAU （recurrent aphthae）, be most common ulcer diseases in oral mucosal disease, the cause of disease is complicated, more with it is immune, hereditary, Systemic disease, infection, environment（Psychology, life, work, social environment）It is relevant etc. factor.Illness rate is typically recognized in crowd For more than 10%, men and women, old and young can be betided, with young and middle-aged most common.Recurrent oral ulceration has self limiting, can with self-healing, Any position of mucous membrane of mouth can be betided, common with lip, cheek, tongue, severe patient can involve pharyngeal mucous membrane.Many patients with The extension of the course of disease, ulcer area increase, number increases, and pain aggravates, and healing stage extends, and interval shortening etc., influences to feed With speak.

Clinical manifestation：

1. minor aphtha：It is sensitive or the congested area of needle point sample size occur from the beginning of lesion, formed in a short time diameter 2~ 4mm, circular or ellipse, the shallow aphtha of clear border.Center micro-pits, surface are covered with one layer of faint yellow pseudomembrane, ulcer week It is in blush shape to enclose mucous membrane hyperemia, and its substrate is laid one's hand on not hard.Ulcer number is generally 2~3.Ulcer has more violent burning after being formed Cusalgia, especially with obvious at the tip of the tongue.When contacting food excitatory more very.Typically without constitutional symptom.

2. rash sample aphtha：Also known as stomatitis type aphtha.This type is except ulcer is small, number is more（Up to 20~30）Outside, it is remaining with it is light The performance of type aphtha is similar.For Sucralfate widely distributed, mucous membrane is congested obvious.Have acutely and with headache, heating, regional nodes The symptoms such as enlargement.

3. periglandular aphtha：Also known as Periadenitis mucous membrane periadenitis or huge aphtha, it is various middle most serious One type.Ulcer often single generation, 2 or more than 2 persons it is rare.Lip inner side and bicker area mucous membrane are apt to occur in, can also be occurred in tongue palate The positions such as bow, soft palate.From the beginning of when ulcer it is identical with minor aphtha, but its diameter is gradually extended to 1~2cm, and to Deep Development To mucous membrane gland.Ulcer can be aubergine, and edge is irregular, is swelled in flap, concavity, and shape is like " crater ".Bottom is uneven, micro- Firmly, in brief summary nodular.Blush is obvious around ulcer.Part has severe pain and can be with whole bodies such as regional glandular enlargement, heatings Symptom.The course of disease is often more than more than the moon, and elder was up to 1 year.Scar is left more afterwards, and severe patient can form tissue defect or deformity.

So, it is art technology with regard to how to find a kind of Chinese medicine composition that can effectively treat recurrent oral ulceration The problem of personnel are urgently to be resolved.

The content of the invention

With the continuous development of China's traditional Chinese medicine, on treatment recurrent oral ulceration, people gradually appreciate The advantages of Chinese traditional treatment recurrent oral ulceration, and good effect, advantage, the pin such as quick, toxic side effect is small over the course for the treatment of To the present situation of existing western medical treatment recurrent oral ulceration, the purpose of the present invention is to be that providing one kind is used to treat recurrent mouth The decoction for oral administration of chamber ulcer, to solve the problems, such as that Blood of Patients with Recurrent Oral is got well early.The medicine is with common Chinese medicine is raw material, by selecting rational medicine and mass parts ratio, can effectively treat above-mentioned recurrent oral ulceration.

To reach the purpose of foregoing invention, the technical solution adopted in the present invention is：There is provided a kind of for treating recurrent The decoction for oral administration and preparation method of canker sore, it is characterised in that each component and mass parts ratio of the decoction for oral administration are as follows It is shown：

3~7g of the coptis, 3~15g of golden cypress, 8~16g of dogwood fruit, 3~10g of radix scutellariae, 6~16g of lucid asparagus, 15~65g of gypsum, half 12~26g of branch lotus, 6~15g of the tuber of dwarf lilyturf, 15~35g of reed rhizome, 9~16g of loguat leaf, cape jasmine（Fry）10~26g, the capsule of weeping forsythia 15~ 30g, 5~16g of the bletilla striata, 9~16g of radix rehmanniae recen, 6~16g of the stem of noble dendrobium, 15~38g of prepared rhizome of rehmannia, 9~35g of rhizoma imperatae.

A kind of decoction for oral administration and preparation method for being used to treat recurrent oral ulceration, it is characterised in that the medicine for oral administration The each component and mass parts of liquid are than as follows：

4~6g of the coptis, 5~13g of golden cypress, 9~14g of dogwood fruit, 5~9g of radix scutellariae, 7~14g of lucid asparagus, 18~56g of gypsum, half 13~23g of lotus, 7~13g of the tuber of dwarf lilyturf, 18~31g of reed rhizome, 10~14g of loguat leaf, cape jasmine（Fry）11~23g, 18~26g of the capsule of weeping forsythia, 6~14g of the bletilla striata, 10~14g of radix rehmanniae recen, 7~14g of the stem of noble dendrobium, 18~32g of prepared rhizome of rehmannia, 10~31g of rhizoma imperatae.One kind is used to treat The decoction for oral administration and preparation method of recurrent oral ulceration, it is characterised in that each component and mass parts of the decoction for oral administration Than as follows：

Coptis 5g, golden cypress 12g, dogwood fruit 13g, radix scutellariae 8g, lucid asparagus 13g, gypsum 48g, Sculellaria barbata 20g, tuber of dwarf lilyturf 12g, reed Root 28g, loguat leaf 13g, cape jasmine（Fry）20g, capsule of weeping forsythia 23g, bletilla striata 13g, radix rehmanniae recen 13g, stem of noble dendrobium 13g, prepared rhizome of rehmannia 26g, cogongrass Root 28g.A kind of decoction for oral administration and preparation method for being used to treat recurrent oral ulceration, it is characterised in that methods described includes Following steps are prepared：

A, after above-mentioned raw materials Chinese medicine being picked into impurity and dust, it is respectively crushed into coarse according to mass parts ratio and decocts a drug wrapped；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and soaks 40min, then again by soaked medicine and soak medicine Clarified solution be put into the lump in marmite, injected medicine 65mm cold boiling water carry out first time high heat decoction, wait decoct arrive 15min When, turn slow fire and boil 35 min, leaching decoction；2. the tepor boiling water that medicine 60mm was re-injected in the dregs of a decoction carries out second of intense fire Decoct, when 10min is arrived in decoction, turn slow fire and boil 30 min, leaching decoction；It is condensed into 3. decoction twice is mixed in 50% Decoction 400ml（Milliliter）.

A kind of decoction for oral administration and preparation method for being used to treat recurrent oral ulceration, it is characterised in that the side of taking Method is：The herb liquid prepared was taken with one day, one portion per day, morning and evening sub-service, dosage 200ml（Milliliter）/ time, before meals partly Hour, which is taken advantage of, to be warmly taken（Avoid eating raw food and maror）.5 days are a course for the treatment of, 1~3 course for the treatment of of taking medicine, canker sore healing, symptom Disappear, disease obtains recovery from illness.

Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component：

The coptis, nature and flavor：It is bitter, cold, there is the effect of purging intense heat, eliminating dampness, removing toxic substances, desinsection, row heat toxin, typhoid fever, excess heat during for treating Vexed, feeling of fullness vomit inverse, bacillary dysentery, heat rush down stomachache, lung knot by, tell, be defeated in battle, lower blood, quench one's thirst, infantile malnutrition due to digestive disturbances or intestinalparasites, roundworm disease, pertussis, throat swell Bitterly, the burning hot wound of pinkeye, aphtha, skin sore, eczema, soup；

Golden cypress, nature and flavor：It is bitter, cold, there is the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment, for treating damp-heat dysentery, Huang Subcutaneous ulcer, band under, heat gonorrhea, tinea pedis, impotence { warding off }, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch, stir-baked CORTEX PHELLODENDRI with salt solution nourishing Yin and falling fire, For fire excess from yin deficiency, night sweat hectic fever due to yin；

Dogwood fruit, nature and flavor：Sour, puckery, tepor, there is filling liver kidney, puckery vital essence, the effect of collapsing admittedly, for treating soreness of waist and knee joint, dizzy Dizzy, tinnitus, impotence, seminal emission, frequent urination, liver cold of insufficiency type heat, incessant sweating due to debility, the heart shake arteries and veins and dissipated；

Radix scutellariae, nature and flavor：It is bitter, cold in nature, have clearing heat-fire, eliminating dampness removing toxic substances, hemostasis, it is antiabortive the effect of, for treating lung heat cough Cough, the headache of high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, irascibility, red eye, swell pain, jaundice with damp-heat pathogen, rush down dysentery, heat gonorrhea, hematemesis blood, uterine bleeding, fetal movement with fever, carbuncle Swollen furunculosis illness；

Lucid asparagus, nature and flavor：It is sweet, bitter, cold in nature, there is the effect of nourishing Yin and moistening dryness, clearing lung-heat fall fire, for treating cough caused by dryness-heat, the moon Consumptive disease is coughed, consumption of YIN caused by febrile disease, Heat Diabetes, dry constipation of intestines, abscess of throat；

Gypsum, nature and flavor：It is sweet, pungent, it is Great Cold, raw to use：Quench the thirst with clearing heat-fire, relieving restlessness, forge use：With expelling pus and promoting granulation, hygroscopic, The effect of hemostasis, for treating the diseases such as the high Sheng of fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, stomach fire, headache, toothache；

Sculellaria barbata, nature and flavor：It is acrid flavour, hardship, cold in nature, there is the effect of heat-clearing, removing toxic substances, scattered stasis of blood, hemostasis, inducing diuresis to remove edema, analgesic therapy, be used for Treatment haematemesis, bleeding from five sense organs or subcutaneous tissue, blood strangury, dysentery characterized by blood in the stool, jaundice, have sore throat, lung carbuncle, furunculosis, scrofula, sore, cancerous swelling, bruise knife wound, snake sting The diseases such as wound；

The tuber of dwarf lilyturf, nature and flavor：Sweet, slight bitter, cold nature, there is the effect of nourishing Yin and moistening lung, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire, for controlling Dryness of the lung dry cough, lung carbuncle are treated, deficiency of Yin overstrain cough, injury thirst, quenches one's thirst, vexed insomnia, have sore throat, dry constipation of intestines, blood-head tells nosebleed；

Reed rhizome, nature and flavor：Nature and flavor：It is sweet, cold, have clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis the effect of, for treat pyreticosis polydipsia, Gastropyretic vomiting, cough with lung heat, lung carbuncle pyemesis, puckery pain of heat gonorrhea；

Loguat leaf, nature and flavor：Bitter, acrid, cold, it is nontoxic, there is the effect of removing heat from the lung to relieve cough, harmonizing stomach and lowering adverse Qi, quench the thirst, for treating lung heat phlegm Cough, the disease such as deficiency of Yin overstrain cough, hemoptysis, bleeding from five sense organs or subcutaneous tissue, stomach hot vomiting；

Cape jasmine（Fry）, nature and flavor：It is bitter, cold, there is the effect of heat-clearing, purging intense heat, cool blood, for treating pyreticosis restlessness of asrhenia type and insomnia, jaundice, leaching Disease, quench one's thirst, hot eyes, pharyngalgia, haematemesis, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer, sprain swelling and pain；

The capsule of weeping forsythia, nature and flavor：It is bitter, cool, there is the effect of heat-clearing, removing toxic substances, dissipating bind, detumescence, for treating warm, erysipelas, macula, large carbuncle The diseases such as pyogenic infections, scrofula, urine leaching closes；

The bletilla striata, nature and flavor：Bitter sweet it is cool, have tonifying lung, hemostasis, detumescence, myogenic, sore the effect of, for treat lung hinder hemoptysis, nosebleed Blood, metal-inflicted wound bleeding, swollen ulcer drug, canker sores, soup fire burn, rhagadia manus et pedis；

Radix rehmanniae recen, nature and flavor：It is sweet, cold, there is the effect of clearing heat and cooling blood, yin-nourishing, promote the production of body fluid, for treating the deep red polydipsia of pyreticosis tongue, the deficiency of Yin The disease such as interior heat, hectic fever due to yin labor heat, Heat Diabetes, haematemesis, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis；

The stem of noble dendrobium, nature and flavor：It is sweet, be slightly cold, have and promote the production of body fluid beneficial stomach, nourishing Yin and clearing heat, moistening lung kidney-nourishing；The effect of improving eyesight strong waist, for treating Consumption of body fluid caused by febrile disease, dry polydipsia, deficiency of stomach-Yin, stomachache retch, dryness of the lung dry cough, abnormal heat are not moved back, impairment of yin mesh is dark, waist and knee is weak；

Prepared rhizome of rehmannia, nature and flavor：Sweet, tepor, there is the effect of nourishing yin and supplementing blood, beneficial to spirit and marrow, for treating the deficiency of liver-yin and kidney-yin, waist and knee acid Soft, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, Poliosis；

Rhizoma imperatae, nature and flavor：It is sweet, cold, have cooling blood and hemostasis, reducing fever and causing diuresis the effect of, for treat blood-head haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, Pyreticosis polydipsia, cough with lung heat, gastropyretic vomiting, jaundice with damp-heat pathogen, oedema oliguria, puckery pain of heat gonorrhea.

Medicine of the present invention is the principle based on Chinese traditional treatment recurrent oral ulceration, from the disease according to recurrent oral ulceration Reason mechanism and pharmacological action are thought：With regard to recurrent oral ulceration, each raw material herbal medicine efficacy in medicine provided by the present invention is total to Play, have good therapeutic effect to above-mentioned disease.

Embodiment

A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned recurrent oral ulceration, using the formula The medicine effect of preparation is good, quick, is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the present invention Embodiment be described in further detail：

Embodiment 1：

It is a kind of to be used to treat the decoction for oral administration of recurrent oral ulceration, it is characterised in that each component of the decoction for oral administration and Mass parts are than as follows：

Coptis 5g, golden cypress 12g, dogwood fruit 13g, radix scutellariae 8g, lucid asparagus 13g, gypsum 48g, Sculellaria barbata 20g, tuber of dwarf lilyturf 12g, reed Root 28g, loguat leaf 13g, cape jasmine（Fry）20g, capsule of weeping forsythia 23g, bletilla striata 13g, radix rehmanniae recen 13g, stem of noble dendrobium 13g, prepared rhizome of rehmannia 26g, cogongrass Root 28g.

Embodiment 2：

It is a kind of to be used to treat the decoction for oral administration of recurrent oral ulceration, it is characterised in that each component of the decoction for oral administration and Mass parts are than as follows：

Coptis 6g, golden cypress 13g, dogwood fruit 14g, radix scutellariae 9g, lucid asparagus 14g, gypsum 56g, Sculellaria barbata 23g, tuber of dwarf lilyturf 13g, reed Root 31g, loguat leaf 14g, cape jasmine（Fry）23g, capsule of weeping forsythia 26g, bletilla striata 14g, radix rehmanniae recen 14g, stem of noble dendrobium 14g, prepared rhizome of rehmannia 32g, cogongrass Root 31g.

Embodiment 3：

It is a kind of to be used to treat the decoction for oral administration of recurrent oral ulceration, it is characterised in that each component of the decoction for oral administration and Mass parts are than as follows：

Coptis 7g, golden cypress 15g, dogwood fruit 16g, radix scutellariae 10g, lucid asparagus 16g, gypsum 65g, Sculellaria barbata 26g, tuber of dwarf lilyturf 15g, reed Root 35g, loguat leaf 16g, cape jasmine（Fry）26g, capsule of weeping forsythia 30g, bletilla striata 16g, radix rehmanniae recen 16g, stem of noble dendrobium 16g, prepared rhizome of rehmannia 38g, cogongrass Root 35g.

Model case

Through clinical conditions Blood of Patients with Recurrent Oral totally 1238, the age is 719, only 519 of more than 33 years old For less than 33 years old.1034 to be fully recovered in 1238 patients, effective 161, invalid 43.Total effective rate is up to 96.5%.

Claims (3)

1. A kind of 1. decoction for oral administration for being used to treat recurrent oral ulceration, it is characterised in that each component of the decoction for oral administration And its mass parts are than as follows：

   3~7g of the coptis, 3~15g of golden cypress, 8~16g of dogwood fruit, 3~10g of radix scutellariae, 6~16g of lucid asparagus, 15~65g of gypsum, half 12~26g of branch lotus, 6~15g of the tuber of dwarf lilyturf, 15~35g of reed rhizome, 9~16g of loguat leaf, cape jasmine（Fry）10~26g, the capsule of weeping forsythia 15~ 30g, 5~16g of the bletilla striata, 9~16g of radix rehmanniae recen, 6~16g of the stem of noble dendrobium, 15~38g of prepared rhizome of rehmannia, 9~35g of rhizoma imperatae.
2. 2. the decoction for oral administration for the treatment of recurrent oral ulceration according to claim 1, it is characterised in that the decoction for oral administration Each component and its mass parts than as follows：

   4~6g of the coptis, 5~13g of golden cypress, 9~14g of dogwood fruit, 5~9g of radix scutellariae, 7~14g of lucid asparagus, 18~56g of gypsum, half 13~23g of lotus, 7~13g of the tuber of dwarf lilyturf, 18~31g of reed rhizome, 10~14g of loguat leaf, cape jasmine（Fry）11~23g, 18~26g of the capsule of weeping forsythia, 6~14g of the bletilla striata, 10~14g of radix rehmanniae recen, 7~14g of the stem of noble dendrobium, 18~32g of prepared rhizome of rehmannia, 10~31g of rhizoma imperatae.
3. 3. the decoction for oral administration of the treatment recurrent oral ulceration according to claim 1 to 2, it is characterised in that described for oral administration The each component and its mass parts of decoction are than as follows：

   Coptis 5g, golden cypress 12g, dogwood fruit 13g, radix scutellariae 8g, lucid asparagus 13g, gypsum 48g, Sculellaria barbata 20g, tuber of dwarf lilyturf 12g, reed Root 28g, loguat leaf 13g, cape jasmine（Fry）20g, capsule of weeping forsythia 23g, bletilla striata 13g, radix rehmanniae recen 13g, stem of noble dendrobium 13g, prepared rhizome of rehmannia 26g, cogongrass Root 28g.