CN104800512A - Chinese medicinal composition for treating lymphnoditis and preparation method - Google Patents
Chinese medicinal composition for treating lymphnoditis and preparation method Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating lymphnoditis, which is mainly prepared from the following raw material medicines in parts by mass: 9 to 13 parts of phellodendron, 10 to 14 parts of portulaca oleracea, 11 to 14 pars of andrographis paniculata, 10 to 15 parts of gentian, 6 to 10 parts of oyster, 8 to 14 parts of ampelopsis japonica, 11 to 16 parts of houttuynia cordata, 9 to 14 parts of myrrh, 12 to 16 parts of iris confuse, 6 to 10 parts of Indian stringbush root, 12 to 17 parts of platycodon grandiflorus, 8 to 15 parts of thesium chinense turcz, 13 to 16 parts of dracocephalum heterophyllum and 7 to 14 parts of pterolobium punctatum. The Chinese medicinal composition is prepared by years of clinical practice summary, has effects of clearing heat and removing toxicity and relieving swelling and pain and has an outstanding curative effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the Chinese medicine composition and preparation method for the treatment of lymphadenitis.
Background technology
Lymphadenitis is the nonspecific inflammation that the Acute and chronic inflammation in drain region belonging to lymph node involves caused by lymph node, and according to onset emergency, course of disease length, lymphadenitis can be divided into acute and chronic lymphadenitis.Acute lymphadenitis has the acute inflammation features such as red, swollen, hot, the pain in local, onset urgency, and often occur together heat, the lymph node softness of enlargement, has tenderness, smooth surface, and without adhesion, namely enlargement extremely to a certain degree stops.Can be disappeared by redness after timely anti-infective therapy.Also abscess can be developed into, with systemic infection symptom during aggravation.The chronic lymphadenitis course of disease is long, mild symptoms, and lymph node is comparatively hard, and movable, tenderness is not obvious, and final lymph node can reduce or disappear.The treatment of acute lymphadenitis, mainly for the timely process of primary lesion; Antibiotic application; Take a good rest; Incision and drainage are answered when being partially formed abscess; And chronic lymphadenitis is usually without the need to special treatment.
Publication No. CN 102406728 A(application number 201110354345.3) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of lymph node inflammation.This pharmaceutical composition is made up of following raw material: Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis; Wherein, the ratio of quality and the number of copies of described Semen Armeniacae Amarum, Pheretima, Calculus Bovis and Semen Plantaginis is (1.8-2.2): (2.7-3.3): (0.9-1.1): (3.6-4.4), preferred mass portion rate is 2: 3: 1: 4.Publication No. CN 104474106 A(application number 201410666626.6) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of acute lymphadenitis, be prepared from by following ratio of weight and number, Exocarpium Benincasae 5-9 part, non-irrigated red lotus 4-9 part, Rhizoma Fagopyri Dibotryis 5-10 part, Radix Rubiae 3-8 part, curb Sui 4-11 part, Herba Adenosmae 4-8 part, Semen Sterculiae Lychnophorae 5-10 part, She Pao le 4-10 part, Fortunella hindsii 6-10 part, Pterospermi Heterophylli 4-9 part.Publication No. CN 104306749 A(application number 201410090387.4) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of acute lymphadenitis, be made up of the raw material of Chinese medicine of following weight: Flos Lonicerae 10-30 gram, Fructus Forsythiae 5-18 gram, Herba Lophatheri 5-18 gram, Fructus Arctii 5-18 gram, Herba Schizonepetae 5-18 gram, Radix Angelicae Dahuricae 5-18 gram, Bulbus Fritillariae Uninbracteatae 10-20 gram, Radix Paeoniae Rubra 5-18 gram, Fructus Trichosanthis 12-30 gram, Rhizoma Coptidis 4-18 gram.
Western medical treatment is based on antibiotic, and it is large to take rear side effect, and relapse rate is high, and adopts Chinese traditional treatment, can treating both the principal and secondary aspects of a disease, and determined curative effect, has advantage better, therefore needs to develop a kind of instant effect, eutherapeutic traditional Chinese medical science formula.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take Chinese medicine composition and the preparation method of the wide treatment lymphadenitis of safe and applicable.
Technical scheme of the present invention is:
The Chinese medicine composition for the treatment of lymphadenitis, is prepared from primarily of following bulk drugs, is mass parts: Cortex Phellodendri 9-13; Herba Portulacae 10-14; Herba Andrographis 11-14; Radix Gentianae 10-15; Concha Ostreae 6-10; Radix Ampelopsis 8-14; Herba Houttuyniae 11-16; Myrrha 9-14; Rhizoma Tupistrae Wattii 12-16; Radix Wikstroemae Indicae 6-10; Radix Platycodonis 12-17; Herba Thesii 8-15; Spend very sweet 13-16 in vain; Herba Damnacanthi 7-14.
Preferred version is, Cortex Phellodendri 10-12; Herba Portulacae 11-13; Herba Andrographis 12-13; Radix Gentianae 11-14; Concha Ostreae 7-9; Radix Ampelopsis 10-12; Herba Houttuyniae 12-15; Myrrha 10-13; Rhizoma Tupistrae Wattii 13-15; Radix Wikstroemae Indicae 7-9; Radix Platycodonis 13-16; Herba Thesii 10-13; Spend very sweet 14-15 in vain; Herba Damnacanthi 9-12.
More preferably, Cortex Phellodendri 11; Herba Portulacae 12; Herba Andrographis 12.5; Radix Gentianae 12.5; Concha Ostreae 8; Radix Ampelopsis 11; Herba Houttuyniae 13.5; Myrrha 11.5; Rhizoma Tupistrae Wattii 14; Radix Wikstroemae Indicae 8; Radix Platycodonis 14.5; Herba Thesii 11.5; Spend very sweet 14.5 in vain; Herba Damnacanthi 10.5.
The Chinese medicine composition of described treatment lymphadenitis, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, soak 12 minutes, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate;
(5) step (1) (3) made crude drug was pulverized 150 mesh sieves, and mixed with step (4) gained filtrate, stir, obtain decoction.
The preparation method of the Chinese medicine composition decoction of described treatment lymphadenitis, the 6-8 that step (4) amount of water is boiled crude drug quality is (preferred: amount of water is 7 times of boiled crude drug quality) doubly.
The Chinese medicine composition of described treatment lymphadenitis, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate after filtering;
(5) step (1) (3) made crude drug was pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, heating is concentrated into thick paste, obtains unguentum.
The preparation method of the Traditional Chinese medicine composition paste of described treatment lymphadenitis, step (4) filtering residue adds water and again decocts 14-26 minute (preferably: filtering residue adds water and again decocts 17-23 minute; Be more preferably: filtering residue adds water and again decocts 20 minutes).
The Chinese medicine composition of described treatment lymphadenitis, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate;
(5) spray drying step (4) gained filtrate, pulverizes and sieves, obtains powder together with step (1) (3) made crude drug.
The preparation method of the Chinese medicine composition composition powders of described treatment lymphadenitis, it is (preferred: to pulverize 180-240 mesh sieve that step (5) pulverized 160-260 mesh sieve; Be more preferably: pulverized 210 mesh sieves).
The Chinese medicine composition of described treatment lymphadenitis, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate;
(5) spray drying step (4) gained filtrate, pulverizes and sieves together with step (1) (3) made crude drug, is added water by made medicated powder generally to make ball, dry under 50 DEG C of environment, obtains pill.
The preparation method of the Chinese medicine composition pill of described treatment lymphadenitis, it is (preferred: to pulverize 100-120 mesh sieve that step (5) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
The Traditional Chinese medicine composition formula science for the treatment of lymphadenitis provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, safe and effective, and side effect is little, and crude drug source is extensive;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic;
3, gained Chinese medicine composition of the present invention meets Chinese medical theory, treating both the principal and secondary aspects of a disease, short treating period, instant effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Cortex Phellodendri: base is former: be the bark of rutaceae Cortex Phellodendri or wampee.Nature and flavor with return through: bitter, cold.Return kidney, urinary bladder channel.Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.For damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, beriberi flaccidity is knitted, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.
Herba Portulacae: nature and flavor with return through acid, cold.Return liver, large intestine channel.Function with cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.Nature and flavor: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." return through: " Quanzhou book on Chinese herbal medicine ": " enters the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.Pharmacological action: 1. antibacterial action 2. antivirus action 3. other effects.
Radix Gentianae: base is former: be the dry root and rhizome of gentianaceae plant Gentiana manshurica, Radix Gentianae, G. triflora or Gentiana rigescens Franch.Nature and flavor: bitter, cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
Concha Ostreae: base is former: be the shell of Ostreidae animal Crassostrea rivularis, long Concha Ostreae or Dalian Bay Concha Ostreae etc.Nature and flavor with return through: salty, be slightly cold.Return liver, gallbladder, kidney channel.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, effect of hard masses softening and resolving.For insomnia of palpitating with fear, dizzy ear toot, scrofula sucutaneous nodule, abdominal mass abdominal mass mass in the abdomen.
Radix Ampelopsis: base is former: be the tuber of vitaceae Radix Ampelopsis.Nature and flavor: bitter; Pungent; Cold nature.Gui Jing: the heart; Lung; Liver; Spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Removing obstruction for relieving pain; Promoting tissue regeneration and ulcer healing.Main sore swollen toxin; Scrofula; Scald; Eczema; Pyrexial malaria; Infantile convulsion; Dysentery; Hemorrhoidal hamorrhage; Anal fistula; Leucorrhea; Traumatic injury; Traumatic hemorrhage.
Herba Houttuyniae: base is former: be the aerial parts of saururaceae plant houttuynia cordata.Nature and flavor: pungent, are slightly cold.Gui Jing: return lung meridian.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Myrrha: base is former: be the gum resin of olive subject plant myrrh or Alan fort myrrh.Chemical analysis: myrrh resinous 25 ~ 35%, volatile oil 2.5 ~ 9%, natural gum about 57 ~ 65% is moisture and various impurity about 3 ~ 4% in addition.Nature and flavor: bitter are flat.Gui Jing: enter Liver Channel.Function cures mainly: loose blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Rhizoma Tupistrae Wattii: base is former: be the rhizome of liliaceous plant handle leaf Tupistra chinensis Bak..Nature and flavor: pungent, bitter, cold, mild toxicity.Function cures mainly: heat-clearing and toxic substances removing, hemostasia and detumescence.
Radix Wikstroemae Indicae: base is former: be root or the root bark of Isolated From Thymelaeaceae Species wikstroemia indica.Nature and flavor: bitter in the mouth; Pungent; Cold in nature; Poisonous.Gui Jing: lung; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Eliminating stagnation removing blood stasis; Diuretic parasite killing.Main pneumonia; Bronchitis; Parotitis; Pharyngolaryngitis; Lymphadenitis; Mastitis; Swollen ulcer drug; Rheumatic arthritis; Edema tympanites; Leprosy; Amenorrhea; Traumatic injury.
Radix Platycodonis: nature and flavor: bitter, pungent is flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Herba Thesii: base is former: be the herb of Santalaceae plant Herba Thesii.Nature and flavor: pungent; Micro-hardship; Cold in nature.Gui Jing: spleen; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing, the kidney invigorating arresting seminal emission.Control acute mastitis, pneumonia, lung abscess, tonsillitis, upper respiratory tract infection; Lumbago due to renal deficiency, dizzy, seminal emission, spermatorrhea.
Spend in vain very sweet: base is former: be the herb of labiate dracocephalum heterophyllum.Nature and flavor: bitter, acrid, cold.Function cures mainly: cough-relieving, clearing away liver-fire, Disperse hepatic depression.For bronchitis, hypertension, thyromegaly, tuberculous lymphadenitis, lymphadenitis; External treating dental ulcer.
Herba Damnacanthi: base is former: Apocynaceae Herba Damnacanthi, is used as medicine with root.Nature and flavor: bitter, pungent, temperature.Function cures mainly: antiinflammatory, antipyretic, pain relieving.Cure mainly icterohepatitis, stomachache, rheumatic arthritis, skin ulcer, furuncle, lymphadenitis, acute conjunctivitis, periodontitis, pharyngolaryngitis.
embodiment 1the Chinese medicine composition for the treatment of lymphadenitis, is prepared from (every part of 10g) primarily of following bulk drugs: Cortex Phellodendri 9 parts, Herba Portulacae 10 parts, Herba Andrographis 11 parts, Radix Gentianae 10 parts, Concha Ostreae 6 parts, Radix Ampelopsis 8 parts, Herba Houttuyniae 11 parts, Myrrha 9 parts, Rhizoma Tupistrae Wattii 12 parts, Radix Wikstroemae Indicae 6 parts, Radix Platycodonis 12 parts, Herba Thesii 8 parts, spend very sweet 13 parts in vain, Herba Damnacanthi 7 parts.The preparation method of the Chinese medicine composition decoction of above-mentioned treatment lymphadenitis is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 26 minutes with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, and spray rice vinegar, stir-fries 6 minutes, take out, cool;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 7 times, big fire is heated to boiling, continue 8 minutes, then add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii and spend in vain very sweet, continue decoction 28 minutes, after filtration, collect filtrate;
(5) step (1) (3) made crude drug was pulverized 150 mesh sieves, and mixed with step (4) gained filtrate, stir, obtain decoction.
embodiment 2the Chinese medicine composition for the treatment of lymphadenitis, is prepared from (every part of 10g) primarily of following bulk drugs: Cortex Phellodendri 13 parts, Herba Portulacae 14 parts, Herba Andrographis 14 parts, Radix Gentianae 15 parts, Concha Ostreae 10 parts, Radix Ampelopsis 14 parts, Herba Houttuyniae 16 parts, Myrrha 14 parts, Rhizoma Tupistrae Wattii 16 parts, Radix Wikstroemae Indicae 10 parts, Radix Platycodonis 17 parts, Herba Thesii 15 parts, spend very sweet 16 parts in vain, Herba Damnacanthi 14 parts.The preparation method of the Traditional Chinese medicine composition paste of above-mentioned treatment lymphadenitis is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 26 minutes with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, and spray rice vinegar, stir-fries 6 minutes, take out, cool;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continues 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continue decoction 28 minutes, after filtration, collect filtrate, filtering residue adds water and again decocts 20 minutes, merges twice gained filtrate after filtering;
(5) step (1) (3) made crude drug was pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, heating is concentrated into thick paste, obtains unguentum.
Model case: xxx, women, 23 years old.Main suit: neck region lump, distending pain one week; Medical history: without obvious inducement, patient found that cervical region had a lump before one week, as beans size, without other untoward reaction, rear lump increases gradually, by being pressed with pain, quality is comparatively hard, removes examination in hospital, is diagnosed as acute lymphadenitis.
Taking this example gained unguentum, each 6-10g, warm boiled water, one day twice, five days is a course for the treatment of, after patient takes a course for the treatment of, pain relief, uncomfortable disease is eliminated substantially, further consultation inspection, and routine blood test is normal, lymph node recovers, and consolidates again drug withdrawal after three days, follows up a case by regular visits in 1 year, do not recur again.
embodiment 3the Chinese medicine composition for the treatment of lymphadenitis, is prepared from (every part of 10g) primarily of following bulk drugs: Cortex Phellodendri 10 parts, Herba Portulacae 11 parts, Herba Andrographis 12 parts, Radix Gentianae 11 parts, Concha Ostreae 7 parts, Radix Ampelopsis 10 parts, Herba Houttuyniae 12 parts, Myrrha 10 parts, Rhizoma Tupistrae Wattii 13 parts, Radix Wikstroemae Indicae 7 parts, Radix Platycodonis 13 parts, Herba Thesii 10 parts, spend very sweet 14 parts in vain, Herba Damnacanthi 9 parts.The preparation method of the Chinese medicine composition composition powders of above-mentioned treatment lymphadenitis is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 26 minutes with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, and spray rice vinegar, stir-fries 6 minutes, take out, cool;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, then add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii and spend in vain very sweet, continue decoction 28 minutes, after filtration, collect filtrate;
(5) spray drying step (4) gained filtrate, pulverized 210 mesh sieves, obtained powder together with step (1) (3) made crude drug.
Model case: xxx, male, 11 years old.Medical history: cat fever suddenly before patient's two weeks, body temperature reaches 38.6 DEG C, rear discovery oxter mild pain, and increase in time, pain increases the weight of, through hospital's ultrasound diagnosis, the superficial lymph knot enlargement of the patient whole body, routine blood test detects quantity of leucocyte and increases, and is diagnosed as acute lymphadenitis.
Recommend to take this example gained powder, each 3-4g, warm boiled water through people, one day twice, within five days, be a course for the treatment of, after patient takes three days, temperature decline is to normal range, pain obviously alleviates, after continuing to take one week, pain disappears, through examination in hospital, inflammation disappears, and routine blood test and lymph node all recover normal.
embodiment 4the Chinese medicine composition for the treatment of lymphadenitis, is prepared from (every part of 10g) primarily of following bulk drugs: Cortex Phellodendri 12 parts, Herba Portulacae 13 parts, Herba Andrographis 13 parts, Radix Gentianae 14 parts, Concha Ostreae 9 parts, Radix Ampelopsis 12 parts, Herba Houttuyniae 15 parts, Myrrha 13 parts, Rhizoma Tupistrae Wattii 15 parts, Radix Wikstroemae Indicae 9 parts, Radix Platycodonis 16 parts, Herba Thesii 13 parts, spend very sweet 15 parts in vain, Herba Damnacanthi 12 parts.The preparation method of the Chinese medicine composition pill of above-mentioned treatment lymphadenitis is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 26 minutes with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, and spray rice vinegar, stir-fries 6 minutes, take out, cool;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, then add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii and spend in vain very sweet, continue decoction 28 minutes, after filtration, collect filtrate;
(5) spray drying step (4) gained filtrate, pulverized 110 mesh sieves together with step (1) (3) made crude drug, was added water by made medicated powder generally to make ball, dry under 50 DEG C of environment, obtained pill.
Model case: xxx, male, 36 years old.Main suit: inguinal lymphadenopathy pain 1 year on the left of patient; Medical history: patient occurs left side inguinal lymphadenopathy without obvious inducement the year before, by being pressed with pain, through examination in hospital, be diagnosed as acute lymphadenitis, after medication treatment, pain relief, lymph node reduces, and drug withdrawal is after three months, Relapse rate, the tangible multiple lymph node of left side groin, mobility is general, and tenderness is obvious.
Through doctor advised, use traditional Chinese medical science expectant treatment, take this example gained pill, each 3-4 grain, warm boiled water, one day twice, it within five days, is a course for the treatment of, after patient takes a course for the treatment of, pain relief, after continuing to take a course for the treatment of, lymph node recovers normal, uncomfortable disease all disappears, and follow up a case by regular visits in 1 year, patient is not recurred.
embodiment 5the Chinese medicine composition for the treatment of lymphadenitis, is prepared from (every part of 10g) primarily of following bulk drugs: Cortex Phellodendri 11 parts, Herba Portulacae 12 parts, Herba Andrographis 12.5 parts, Radix Gentianae 12.5 parts, Concha Ostreae 8 parts, Radix Ampelopsis 11 parts, Herba Houttuyniae 13.5 parts, Myrrha 11.5 parts, Rhizoma Tupistrae Wattii 14 parts, Radix Wikstroemae Indicae 8 parts, Radix Platycodonis 14.5 parts, Herba Thesii 11.5 parts, spend very sweet 14.5 parts in vain, Herba Damnacanthi 10.5 parts.The preparation method of the Chinese medicine composition decoction of above-mentioned treatment lymphadenitis is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 26 minutes with vinegar, take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, and spray rice vinegar, stir-fries 6 minutes, take out, cool;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 7 times, big fire is heated to boiling, continue 8 minutes, then add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii and spend in vain very sweet, continue decoction 28 minutes, after filtration, collect filtrate;
(5) step (1) (3) made crude drug was pulverized 150 mesh sieves, and mixed with step (4) gained filtrate, stir, obtain decoction.
test example 1the clinical practice of the Chinese medicine composition (embodiment 5) of gained treatment lymphadenitis of the present invention:
Choose crowd: in January, 2013 in December ,-2014, according to medical case history, be diagnosed as patient 375 example of lymphadenitis four hospitals' screenings, age 10-58 year, 34.1 ± 1.6 years old mean age, the course of disease more than 4 days, wherein male patient 192 example, female patient 183 example.Diagnostic criteria: 1. at place's nuclei of origin shape lumps such as jaw, neck, axil, groin, have relieving distension history repeatedly from the beginning of the hot pain of color of the leather constant ， inflammation or lump; 2. the symptoms such as fear of cold, heating, headache, general malaise are had; 3. premorbid has affection due to external wind and heat more and has acute and chronic infection focus or skin trauma history at corresponding site or formed by acute lymphadenitis delay; 4. blood leukocytes sum and neutrophilic granulocyte increase.Exclusion standard: the acute lymphadenitis 1. having formed abscess; 2. severe cardiac, brain, liver, kidney diaseases, malignant tumor patient is had; 3. gestation and women breast-feeding their children; 4. due to lymphadenectasis that tuberculosis, tumor etc. cause; 5. severe infection and multiple infection person, use other antibacterials person.
Before test, patient is divided into two groups at random, experimental group 225 example and matched group 150 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, one day twice, each 200-280ml, warmly takes, and within five days, is a course for the treatment of; Matched group takes other conventional medicines (anti inflammatory blood quickening ball, SANHUANG PIAN, XIHUANG WAN or zijin troche etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) fully recovers: clinical symptom disappearance, and lump dissipates, and routine blood test and body temperature all recover normal; (2) effective: clinical symptom disappearance, lump obviously reduces, and leukocyte and body temperature reduce; (3) invalid: clinical symptoms without improvement, lump without reducing, routine blood test and body temperature unchanged.
Clinical effectiveness: after the medication treatment of two courses for the treatment of, the therapeutic outcome of two groups is as follows:
Experimental group: 182 examples of fully recovering (80.9%), effective 40 examples (17.8%), invalid 3 examples (1.3%), total effective rate is 98.7%;
Matched group: 106 examples of fully recovering (70.7%), effective 27 examples (18.0%), invalid 17 examples (11.3%), total effective rate is 88.7%.
Follow up a case by regular visits in 1 year, no case was recurrence for experimental group, and recur 11 examples (10.4%) in matched group, and therefore the therapeutic effect of experimental group is obviously better than matched group, illustrates that products obtained therefrom therapeutic effect of the present invention is good, can effectively diminish inflammation, and prevents recurrence.
The Chinese medicine used in the present invention, multiple medical material synergism, Cortex Phellodendri, Radix Gentianae can heat clearing and damp drying, Herba Portulacae can heat-clearing and toxic substances removing, Herba Andrographis can removing heat from blood detumescence, and Concha Ostreae can hard masses softening and resolving, and Radix Ampelopsis can removing obstruction for relieving pain, Herba Houttuyniae can eliminating carbuncle evacuation of pus, Myrrha can subduing swelling and relieving pain, and Rhizoma Tupistrae Wattii can hemostasia and detumescence, and Radix Wikstroemae Indicae can eliminating stagnation removing blood stasis, Radix Platycodonis can lung qi dispersing sore-throat relieving, Herba Thesii can the kidney invigorating arresting seminal emission, spend in vain very sweet can purging liver-fire, Herba Damnacanthi can anti-inflammatory analgetic, for lymphadenitis, play effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine composition of lymphadenitis, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Cortex Phellodendri 9-13; Herba Portulacae 10-14; Herba Andrographis 11-14; Radix Gentianae 10-15; Concha Ostreae 6-10; Radix Ampelopsis 8-14; Herba Houttuyniae 11-16; Myrrha 9-14; Rhizoma Tupistrae Wattii 12-16; Radix Wikstroemae Indicae 6-10; Radix Platycodonis 12-17; Herba Thesii 8-15; Spend very sweet 13-16 in vain; Herba Damnacanthi 7-14.
2. the Chinese medicine composition for the treatment of lymphadenitis as claimed in claim 1, is characterized in that, Cortex Phellodendri 10-12; Herba Portulacae 11-13; Herba Andrographis 12-13; Radix Gentianae 11-14; Concha Ostreae 7-9; Radix Ampelopsis 10-12; Herba Houttuyniae 12-15; Myrrha 10-13; Rhizoma Tupistrae Wattii 13-15; Radix Wikstroemae Indicae 7-9; Radix Platycodonis 13-16; Herba Thesii 10-13; Spend very sweet 14-15 in vain; Herba Damnacanthi 9-12(is preferably: Cortex Phellodendri 11; Herba Portulacae 12; Herba Andrographis 12.5; Radix Gentianae 12.5; Concha Ostreae 8; Radix Ampelopsis 11; Herba Houttuyniae 13.5; Myrrha 11.5; Rhizoma Tupistrae Wattii 14; Radix Wikstroemae Indicae 8; Radix Platycodonis 14.5; Herba Thesii 11.5; Spend very sweet 14.5 in vain; Herba Damnacanthi 10.5).
3. the Chinese medicine composition of the treatment lymphadenitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, soak 12 minutes, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate;
(5) step (1) (3) made crude drug was pulverized 150 mesh sieves, and mixed with step (4) gained filtrate, stir, obtain decoction.
4. the preparation method of the Chinese medicine composition decoction for the treatment of lymphadenitis as claimed in claim 3, is characterized in that, the 6-8 that step (4) amount of water is boiled crude drug quality is (preferred: amount of water is 7 times of boiled crude drug quality) doubly.
5. the Chinese medicine composition of the treatment lymphadenitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate after filtering;
(5) step (1) (3) made crude drug was pulverized 120 mesh sieves, and mixed with step (4) gained filtrate, heating is concentrated into thick paste, obtains unguentum.
6. the preparation method of the Traditional Chinese medicine composition paste for the treatment of lymphadenitis as claimed in claim 5, is characterized in that, step (4) filtering residue adds water and again decocts 14-26 minute (preferably: filtering residue adds water and again decocts 17-23 minute; Be more preferably: filtering residue adds water and again decocts 20 minutes).
7. the Chinese medicine composition of the treatment lymphadenitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate;
(5) spray drying step (4) gained filtrate, pulverizes and sieves, obtains powder together with step (1) (3) made crude drug.
8. the preparation method of the Chinese medicine composition composition powders for the treatment of lymphadenitis as claimed in claim 7, it is characterized in that, it is (preferred: to pulverize 180-240 mesh sieve that step (5) pulverized 160-260 mesh sieve; Be more preferably: pulverized 210 mesh sieves).
9. the Chinese medicine composition of the treatment lymphadenitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Cortex Phellodendri, Rhizoma Tupistrae Wattii and Radix Wikstroemae Indicae and pick up clean impurity, be placed in steamer, fumigate 18-34 minute (preferably: fumigate 22-30 minute with vinegar with vinegar; Be more preferably: fumigate 26 minutes with vinegar), take out, be applied to surface with refined honey water, shredding, oven dry;
(2) get Concha Ostreae to clean, pound into fritter, be placed in marmite, add Chinese liquor and be heated to boiling, take out, dry, cool;
(3) cleaned by Myrrha, heating in water bath melts, and crosses and filters impurity, be condensed into paste, dries to tack-free, then is placed in frying pan for 60 DEG C, spray rice vinegar, and stir-fry 4-8 minute (preferred: to stir-fry 6 minutes), takes out, cools;
(4) by Radix Gentianae, Radix Ampelopsis, Herba Houttuyniae, Radix Platycodonis and Herba Damnacanthi removing impurity, clean, add the water soaking 12 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, continue 8 minutes, add step (2) institute's Concha Ostreae (processed) and clean Herba Portulacae, Herba Andrographis, Herba Thesii again and spend in vain very sweet, continuing to decoct 20-36 minute (preferably: continue to decoct 24-32 minute; Be more preferably: continue decoction 28 minutes), after filtration, collect filtrate;
(5) spray drying step (4) gained filtrate, pulverizes and sieves together with step (1) (3) made crude drug, is added water by made medicated powder generally to make ball, dry under 50 DEG C of environment, obtains pill.
10. the preparation method of the Chinese medicine composition pill for the treatment of lymphadenitis as claimed in claim 9, it is characterized in that, it is (preferred: to pulverize 100-120 mesh sieve that step (5) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
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