CN101229306A - Guyinjian oral preparation and preparing method thereof - Google Patents
Guyinjian oral preparation and preparing method thereof Download PDFInfo
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- CN101229306A CN101229306A CNA2008100075318A CN200810007531A CN101229306A CN 101229306 A CN101229306 A CN 101229306A CN A2008100075318 A CNA2008100075318 A CN A2008100075318A CN 200810007531 A CN200810007531 A CN 200810007531A CN 101229306 A CN101229306 A CN 101229306A
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Abstract
The invention relates to an oral preparation of consolidating-yin decoction medicine, which is prepared with ginseng and other seven Chinese medicines mainly for treating yin deficiency and emission, turbid leucorrhea and dribbling and non-consolidation of menses resulted from deficiency, and the preparation method thereof. The oral preparation is prepared according to the conventional processes and utilizing the mixed extracts as raw materials, such as ginseng, old land, Chinese yam, cornus officinalis, dodder, milkwort, schisandra chinensis and baked licorice, together with vector or excipient which are utilized as matrix and acceptable in pharmacy. The preparation has the effects of reinforcing kidney and regulating menstruation, and mainly treats yin deficiency and frequent diarrhea, turbid leucorrhea and dribbling and non-consolidation of menses resulted from deficiency. The long-term clinical application of the prescription shows that the preparation has good effects on menoxenia, dysfunctional uterine bleeding, infertility, amenorrhea and nocturnal emission, etc.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of deficiency of YIN lingering diarrhea that cures mainly, foul leukorrhea drench to lose and through water because of not solid oral formulations of void and preparation method thereof, particularly to fry in shallow oil the extract of Chinese medicine prescription be the oral formulations of active constituents of medicine to Yi Guyin.
Background technology
" Gu Yin fries in shallow oil " is to formulate in Ming Dynasty's Zhang Jingyue Jing-Yue Complete Works, always as the side commonly used of invigorating kidney for regulating menstruation, formed by Radix Ginseng, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Radix Polygalae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata, effect with invigorating kidney for regulating menstruation, cure mainly deficiency of YIN lingering diarrhea, foul leukorrhea drenches to be lost and not to demonstrate,prove admittedly because of void through water.This prescription long-term clinical application demonstration, to the treatment menoxenia, dysfunctional uterine bleeding, infertility, amenorrhea, nocturnal emissions etc. have better curative effect, and have application widely, and also significantly malicious secondary of discovery is answered.
The source of the Chinese crude drug of " Gu Yin fries in shallow oil " is as follows:
Radix Ginseng: the root for the Araliaceae Radix Ginseng, strongly invigorating primordial QI is arranged, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the effect of calming the nerves.
Radix Rehmanniae Preparata: the processed product of the tuber of scrophulariaceae rehmannia glutinosa plant has heart tonifying, diuresis, blood sugar lowering and rising peripheral leukocytes, effects such as raise immunity
Rhizoma Dioscoreae: for Dioscoreaceae plant Rhizoma Dioscoreae rhizome, the spleen reinforcing nourishing the stomach is arranged, the lung benefiting that promotes the production of body fluid, the effect of the kidney invigorating arresting seminal emission.
Fructus Corni: Cornaceae plant Fructus Corni pulp has liver and kidney tonifying, the effect of essence astringing and desertion stemming.
Semen Cuscutae: the seed for convolvulus cuscuta plant, nourishing the liver and kidney is arranged, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright the antidiarrheal effect.
Radix Polygalae: be the root of milk wort Radix Polygalae, have and calm the nerves that Fructus Alpiniae Oxyphyllae is eliminated the phlegm, the repercussive effect.
Fructus Schisandrae Chinensis: for the fruit of Drymotaenium miyoshianum (Mak.) Mak. kind of plant Fructus Schisandrae Chinensis, astringe the lung, nourishing kidney is promoted the production of body fluid, and receives antiperspirant, the effect of arresting seminal emission.
Radix Glycyrrhizae Preparata: be the leguminous plant Radix Glycyrrhizae, the dry root and rhizome of expand dried fruits grass or light dried fruits grass has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain and coordinating the actions of various ingredients in a prescription.
The Fang Zhongyong Radix Rehmanniae Preparata, Fructus Corni, the Semen Cuscutae the kidney invigorating and essence nourishing, Radix Ginseng, Rhizoma Dioscoreae, the Radix Glycyrrhizae QI invigorating is good for Pi, Fructus Schisandrae Chinensis, the Radix Polygalae restoring normal coordination between the heart and kidney, Quan Fangxin, kidney, spleen is mended altogether, reaches the effect of invigorating kidney for regulating menstruation.
" Gu Yin fries in shallow oil " in ancient times do not have only decoction, decoct behind the needs purchase decoction pieces and take, carry take all very inconvenient, we quantitatively control by index components and make the modern Chinese medicine oral formulations through studying, and product dosage is accurate, steady quality, conveniently take, be applicable to the big production of commercialization, overcome that the Chinese medicine decoction consumption is big, consumption is inaccurate, carry take inconvenience, can't commercialization etc. shortcoming, the needs that make things convenient for clinical treatment and family to use.
Summary of the invention
The objective of the invention is to preparation method according to modern Chinese medicine, quantitatively control by index components and to make the modern Chinese medicine oral formulations, with bupleurum powder for relieving liver-qi be developed to product dosage accurately, steady quality, conveniently take, be applicable to the Chinese patent medicine of the big production of commercialization, make things convenient for clinical treatment and family to use.
The medicine of oral formulations involved in the present invention is by Radix Ginseng, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Radix Polygalae, Fructus Schisandrae Chinensis, the mixed extract of Radix Glycyrrhizae Preparata (extractum or dry powder) is a raw material, with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, because it is slightly different to record " Gu Yin fries in shallow oil " recipe quantity in the different medical books, each flavour of a drug and weight fraction (unit is g or kg) are in preparation the present invention prescription:
Radix Ginseng 1-15 part, Radix Rehmanniae Preparata 2-20 part, Rhizoma Dioscoreae 2-20 part, Fructus Corni 2-20 part, Semen Cuscutae 2-20 part, Radix Polygalae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Radix Glycyrrhizae Preparata 1-10 part
Most preferably each flavour of a drug and weight fraction (unit is g or kg) are in the prescription:
Radix Ginseng 8-10g, Radix Rehmanniae Preparata 9-15g, Rhizoma Dioscoreae 9-24g, Fructus Corni 9-15g, Semen Cuscutae 9-20g, Radix Polygalae 6-12g, Fructus Schisandrae Chinensis 6-12g, Radix Glycyrrhizae Preparata 6-12g
Substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;
Proportioning: extract (water extract: extractum or dry powder): substrate=9: 1～1: 9.
The extraction process of the present invention's " Gu Yin fries in shallow oil " mixed extract (water extract) is as follows:
(1) each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges;
(2) aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;
(3) " Gu Yin fries in shallow oil " extract (water extract) and pharmaceutically acceptable carrier or excipient composition routinely technology make various oral administration solids or liquid preparation, wherein said carrier or excipient pharmaceutically selected according to different dosage forms, and these used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
The extracting method of the present invention's " Gu Yin fries in shallow oil " extract is a lot, has only provided a kind of method here, but is not limited to this kind method.
Medicine of the present invention, wherein dosage form comprises oral solid formulation and oral liquid, wherein oral solid formulation comprises: tablet, hard capsule, liquid type capsule, granule, soft capsule, drop pill, pill, pellet, slow releasing preparation; Oral liquid comprises: oral liquid, syrup, medicated wine; Granule wherein, oral liquid, hard capsule and additive of tablet are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate, mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, polyethylene compares pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more; Wherein the adjuvant of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C
5-C
14Triglyceride, in the ethyl oleate one or more, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
Pharmaceutical preparation of the present invention, wherein tablet specifically refers to common compressed tablet, coated tablet, coated tablet, Film coated tablets, enteric coated tablet, effervescent tablet, chewable tablet, multilayer tablet, dispersible tablet, Sublingual tablet, buccal tablet.
Pharmaceutical preparation of the present invention wherein can also contain aromatic and antiseptic, and wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
" Gu Yin fries in shallow oil " method for preparing extractive is as follows:
Prescription: Radix Ginseng 8-10g, Radix Rehmanniae Preparata 9-15g, Rhizoma Dioscoreae 9-24g, Fructus Corni 9-15g, Semen Cuscutae 9-20g, Radix Polygalae 6-12g, Fructus Schisandrae Chinensis 6-12g, Radix Glycyrrhizae Preparata 6-12g
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material of recipe quantity and adds 6～20 times of water gagings and soaked heating extraction 2-3 time, extracting solution merging 2-12 hour; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and concentrating under reduced pressure gets extractum or spray drying is that dry powder is that water extract is standby.
Preparation " Gu Yin fries in shallow oil " oral liquid and syrup
" Gu Yin fries in shallow oil " extract and correctives, antiseptic and water are made oral liquid, and wherein correctives is selected from one or more in sucrose, saccharin sodium, sodium cyclamate, stevioside, aspartoyl aminotoluene acid methyl ester, the Oleum menthae (alcohol); Antiseptic is selected from sorbic acid methyl ester, benzoic acids, you moor in golden class etc. one or more.
The preparation method of oral liquid and syrup is as follows: " Gu Yin fries in shallow oil " extract adds water to be adjusted to preparation amount, adds correctives, antiseptic mix homogeneously, through technologies such as sterilization, fill, check, packings, promptly gets jichuan decoction oral liquid and syrup.
Wherein the weight percent content of Jia Ruing is: " Gu Yin fries in shallow oil " extract 5-80%, correctives 0.05-5%, antiseptic 0.001-2%, water 10-90%.
Preparation " Gu Yin fries in shallow oil " granule, pill, pellet, capsule, tablet
Granule, pill, pellet, capsule, and tablet are made the used adjuvant of concentrated granule or pill or tablet and are comprised diluent, binding agent, lubricant; Diluent is selected from one or more of starch, lactose, dextrin, microcrystalline Cellulose kind; Binding agent comprise water, macromolecular material and alcoholic acid one or more; Lubricant comprises one or more in magnesium stearate, Pulvis Talci, the stearic acid.
Granule, pill, pellet, capsule, and the preparation method of tablet as follows:
With " Gu Yin fries in shallow oil " extract and an amount of pharmaceutic adjuvant mixing, adding binding agent etc. is made soft material, makes granule with granulator, and dry, granulate promptly gets granule, or the general pill of making, or makes capsule through capsule filling machine, or makes tablet through tabletting.
Granule, pill, pellet, capsule, and tablet, wherein every gram granule is equivalent to contain the crude drug amount of 0.1-10 gram.
Preparation " Gu Yin fries in shallow oil " drop pill
The used adjuvant of preparation drop pill comprises substrate, liquid coolant.Substrate comprises one or more of Polyethylene Glycol, polyvidone, octadecanol, cholic acid apoplexy due to endogenous wind; Liquid coolant comprises one or more in water, dimethicone, vegetable oil, the liquid Paraffin.Get the substrate heating and melting, bavin " Gu Yin fries in shallow oil " extract is mixed wherein, splash in the suitable liquid coolant, drying is made, and wherein every gram drop pill is equivalent to contain the crude drug amount of 0.1-10 gram.
Preparation " Gu Yin fries in shallow oil " soft capsule
With " Gu Yin fries in shallow oil " extract and adjuvant diluent, antioxidant, antiseptic, suspending agent, wherein diluent is selected from one or more in Polyethylene Glycol, propylene glycol, vegetable oil, the mineral oil; Antioxidant is selected from that glycine, vitamin E and derivant thereof, ascorbic acid, pyrosulfurous acid are received, in the potassium metabisulfite one or more; Antiseptic comprises one or more in sorbic acid methyl ester, benzoic acids, the parabens etc.; Suspending agent is selected from one or more in chitin, cellulose family, agar, the Cera Flava.
Preparation method is as follows: " Gu Yin fries in shallow oil " extract 5-50%, add an amount of diluent, antioxidant, antiseptic, suspending agent mix homogeneously, prepared forms routinely, and wherein every gram soft capsule is equivalent to contain the crude drug amount of 0.1-10 gram.
Specific embodiment
Embodiment one: " Gu Yin fries in shallow oil " extract 1 (extractum) preparation method
Prescription: Radix Ginseng 10g, Radix Rehmanniae Preparata 15g, Rhizoma Dioscoreae 24g, Fructus Corni 15g, Semen Cuscutae 20g, Radix Polygalae 10g, Fructus Schisandrae Chinensis 10g, Radix Glycyrrhizae Preparata 10g
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 6～15 times of water gagings and soaks 2-10 hour, heat little boiling and extracts 2-3 time, the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, and it is the about 21.4g of water extract that concentrating under reduced pressure gets extractum.
Embodiment two: " Gu Yin fries in shallow oil " extract 2 (dry powder) preparation method
Prescription: Radix Ginseng 9g, Radix Rehmanniae Preparata 9g, Rhizoma Dioscoreae 9g, Fructus Corni 9g, Semen Cuscutae 9g, Radix Polygalae 6g, Fructus Schisandrae Chinensis 6g, Radix Glycyrrhizae Preparata 6g
Method for making: the medical material of respectively distinguishing the flavor of of will writing out a prescription cleans, and takes by weighing each medical material by recipe quantity, adds 8～10 times of water gagings and soaks 2-8 hour, and being heated to boils extracts 2-3 time, the extracting solution merging; Aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure, and it is the about 18.1g of water extract that spray drying gets dry powder.
Embodiment three: " Gu Yin fries in shallow oil " oral solid formulation preparation method
(1) preparation " Gu Yin fries in shallow oil " granule
Prescription:
" Gu Yin fries in shallow oil " extract 1 10-90%
Starch 5.0-70%
Dextrin 2.0-20%
Xylitol 5.0-20%
Sorbic acid methyl ester 0.001-2.0%
Optimizing prescriptions:
" Gu Yin fries in shallow oil " extract 1 21.4g
Starch 3.0g
Dextrin 10.0g
Xylitol 5.0g
Sorbic acid methyl ester 0.002g
Method for making: by the preparation of the method among the embodiment one " Gu Yin fries in shallow oil " extract, add the recipe quantity adjuvant and make granule according to a conventional method, drying, packing is made.
(2) preparation " Gu Yin fries in shallow oil " tablet:
(1) ordinary tablet prescription:
" Gu Yin fries in shallow oil " extract 2 5.0-90%
Starch 5.0-50%
Dextrin 2.0-20%
Microcrystalline Cellulose 5.0-20%
Pulvis Talci 0.5-5.0%
Magnesium stearate 0.1-5.0%
Optimizing prescriptions:
" Gu Yin fries in shallow oil " extract 2 18.1g
Starch 10g
Dextrin 3g
Microcrystalline Cellulose 2g
Pulvis Talci 0.2g
Magnesium stearate 0.1g
Method for making: by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, add the recipe quantity adjuvant and make granule according to a conventional method, drying, tabletting is promptly.
(2) effervescent tablet is write out a prescription and is prepared as follows:
Prescription: " Gu Yin fries in shallow oil " extract 2 18.1g
Starch 2g
Dextrin 8g
Microcrystalline Cellulose 2g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Anhydrous citric acid 1.0g
Sodium bicarbonate 2.0g
Lactose 5g
Water is an amount of
Method for making: by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, add the recipe quantity adjuvant and make granule according to a conventional method, drying, tabletting is promptly.
(3) buccal tablet is write out a prescription and is prepared as follows:
Prescription: " Gu Yin fries in shallow oil " extract 2 18.1g
Starch 2g
Dextrin 6g
Microcrystalline Cellulose 3g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Citric acid 0.5g
Aspartame 0.02g
Water is an amount of
Method for making: by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, add the recipe quantity adjuvant and make granule according to a conventional method, drying, tabletting is promptly.
(4) coated tablet is write out a prescription and is prepared as follows:
Prescription: " Gu Yin fries in shallow oil " extract 2 18.1g
Starch 10g
Dextrin 2g
Microcrystalline Cellulose 2g
Pulvis Talci 0.1g
Magnesium stearate 0.1g
Method for making:, add the recipe quantity adjuvant and make granule, drying according to a conventional method by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, tabletting, make coating material according to conventional method, with coating machine coating promptly, can be bundled into sugar-coat and film-coat according to the difference of coating material.
(3) preparation " Gu Yin fries in shallow oil " drop pill
Prescription:
" Gu Yin fries in shallow oil " extract 2 10-70%
Macrogol 4000 20-80%
Polyethylene glycol 6000 20.0-50%
Liquid paraffin is an amount of
Optimizing prescriptions:
" Gu Yin fries in shallow oil " extract 2 18.1g
Macrogol 4000 10g
Polyethylene glycol 6000 10g
Liquid paraffin is an amount of
Method for making: Macrogol 4000 and the polyethylene glycol 6000 ratio in 1: 1 is added in the lead pan of drop pill machine, in oil bath, be heated to 90-100 ℃, treat whole fusions after, add by the method among the embodiment two and prepare " Gu Yin fries in shallow oil " extract 2, be stirred to fusion, be transferred in the reservoir, airtight and the insulation at 80-90 ℃, regulator solution titer valve, splash in 10-15 ℃ the liquid paraffin, fish for the drop pill drop to the greatest extent and wipe liquid Paraffin, put in the Calx cylinder dry, both.
(4) preparation " Gu Yin fries in shallow oil " pill
Prescription:
" Gu Yin fries in shallow oil " extract 2 18.1g
Starch 10g
Magnesium stearate 0.1g
Dextrin 3g
Water is an amount of
Method for making: by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, add the recipe quantity adjuvant and make granule according to a conventional method, drying, pelleting is promptly.
(5) preparation " Gu Yin fries in shallow oil " soft capsule
The content prescription:
" Gu Yin fries in shallow oil " extract 2 18.1g
Vegetable oil 20g
Ethylparaben 0.01g
Cera Flava 4g
Method for making: by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, add vegetable oil, the Cera Flava of optimizing prescriptions percentage amounts, ethylparaben prepared routinely forms.
(6) preparation " Gu Yin fries in shallow oil " capsule
Prescription:
" Gu Yin fries in shallow oil " extract 2 10-95%
Starch 5-55%
Magnesium stearate 0.1-5%
Optimizing prescriptions:
" Gu Yin fries in shallow oil " extract 2 18.1g
Starch 10g
Magnesium stearate 0.5g
Method for making: by the preparation of the method among the embodiment two " Gu Yin fries in shallow oil " extract, add the recipe quantity adjuvant and make granule according to a conventional method, drying, fill is promptly.
Embodiment four: " Gu Yin fries in shallow oil " oral liquid preparation method
Prescription: " Gu Yin fries in shallow oil " extract 1 5-80%
Sucrose 5.0-50%
Sodium cyclamate 5.0-40%
Sorbic acid methyl ester 0.001-2%
Distilled water 10-90%.
Optimizing prescriptions:
" Gu Yin fries in shallow oil " extract 1 21.4g
Sucrose 2.0g
Sodium cyclamate 0.5g
Sorbic acid methyl ester 0.002g
Distilled water is settled to 60ml.
Method for making: by the preparation of the method among the embodiment one " Gu Yin fries in shallow oil " extract, add each adjuvant of prescription and distilled water, again through the ultrafilter ultrafiltration, the ultrafiltrate fill, sterilization, promptly.
Claims (7)
- One kind by 8 flavor Chinese medicines preparations such as Radix Ginseng cure mainly deficiency of YIN lingering diarrhea, foul leukorrhea drench lose and through water because of the void Gu Yin of solid card composition oral preparation and preparation method thereof of boiling medicine, mixed extract with Radix Ginseng, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Semen Cuscutae, Radix Polygalae, Fructus Schisandrae Chinensis and Radix Glycyrrhizae Preparata is a raw material, with as the pharmaceutically acceptable carrier of substrate or excipient routinely prepared form, wherein:1.1 each flavour of a drug and shared percentage by weight (unit is g or kg) are in the prescription:Radix Ginseng 1-15 part, Radix Rehmanniae Preparata 2-20 part, Rhizoma Dioscoreae 2-20 part, Fructus Corni 2-20 part, Semen Cuscutae 2-20 part, Radix Polygalae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Radix Glycyrrhizae Preparata 1-10 partEach flavour of a drug and weight fraction in the optimizing prescriptions (unit is g or kg) are:Radix Ginseng 8-10g, Radix Rehmanniae Preparata 9-15g, Rhizoma Dioscoreae 9-24g, Fructus Corni 9-15g, Semen Cuscutae 9-20g, Radix Polygalae 6-12g, Fructus Schisandrae Chinensis 6-12g, Radix Glycyrrhizae Preparata 6-12g1.2 substrate: the common medicinal supplementary material in the medicament book in preparation oral administration solid and the liquid preparation;1.3 proportioning: extract (comprise water extract: extractum or dry powder): substrate=9: 1～1: 9.
- 2. fry in shallow oil extract according to the Gu Yin in the claim 1, its preparation technology is as follows:1.1 each flavor medical material is cleaned, take by weighing each medical material and add 6～20 times of water gagings by best deal and soaked 2-12 hour, heating extraction 2-3 time, extracting solution merges;1.2 aqueous extract left standstill 12-48 hour, crossed the leaching supernatant, concentrating under reduced pressure gets extractum or spray drying, and to get dry powder be water extract;1.3 Gu Yin fries in shallow oil water extract and volatile oil and carrier pharmaceutically or adjuvant root and makes up routinely technology and make various oral administration solids or liquid preparation, these wherein used carriers or excipient can determine for the those of ordinary skill of pharmaceutical field.
- 3. according to the Guyinjian oral pharmaceutical preparation among the claim 1-2, wherein dosage form comprises tablet, hard capsule, granule, soft capsule, liquid type capsule, drop pill and oral liquid, wherein:1.1 granule, tablet, hard capsule and oral liquid liquid preparation substrate are selected from starch, sodium bicarbonate, Icing Sugar, lactose, amylum pregelatinisatum, microcrystalline Cellulose, inorganic salts (mainly is some inorganic calcium salts, as calcium sulfate, citric acid, calcium hydrogen phosphate and medicinal calcium carbonate), mannitol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose and ethyl cellulose, hydroxypropyl emthylcellulose, hypromellose, other binding agent, dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone, cross-linking sodium carboxymethyl cellulose, magnesium stearate, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, in polyethylene glycols (Macrogol 2000-6000) and month pure magnesium sulfate of extension and the xylitol one or more.1.2 the substrate of soft capsule, liquid type capsule and drop pill is selected from Polyethylene Glycol (Macrogol 200-6000), propylene glycol, Cera Flava, Lac, polyoxyethylene monostearate, glycerol, ethanol, (polysorbas20,40,60,65,80), spans (span 20,40,60,65,80), soybean oil, Oleum Camelliae, safflower oil, Radix Oenotherae erythrosepalae oil, olive oil, C 5-C 14Triglyceride, in the ethyl oleate one or more.
- 4. according to the pharmaceutical preparation among the claim 1-3, wherein tablet specifically refers to common compressed tablet, coated tablet, coated tablet, Film coated tablets, enteric coated tablet, effervescent tablet, chewable tablet, multilayer tablet, dispersible tablet, Sublingual tablet, buccal tablet.
- 5. according to the pharmaceutical preparation among the claim 1-4, can also dose antioxidant, be selected from alpha-tocopherol, ascorbyl palmitate, Butylated hydroxyanisole (BHA), the dibenzylatiooluene (BHT) one or more.
- 6. according to the pharmaceutical preparation among the claim 1-5, wherein can also contain aromatic and antiseptic, wherein aromatic comprises one or more in Fructus Citri tangerinae essence, flavoring banana essence, strawberry essence, the cream flavour, and antiseptic comprises one or more in parabens, the benzoic acids.
- 7. according to the composition oral preparation of boiling medicine of the Gu Yin among the claim 1-6, said preparation has the effect of invigorating kidney for regulating menstruation, cure mainly deficiency of YIN lingering diarrhea, foul leukorrhea drench lose and through water because of void card admittedly, this prescription long-term clinical application shows, to treatment menoxenia, dysfunctional uterine bleeding, infertility, amenorrhea, nocturnal emission etc. have better curative effect.
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| CNA2008100075318A CN101229306A (en) | 2008-02-27 | 2008-02-27 | Guyinjian oral preparation and preparing method thereof |
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| CNA2008100075318A CN101229306A (en) | 2008-02-27 | 2008-02-27 | Guyinjian oral preparation and preparing method thereof |
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| CN113633733A (en) * | 2021-04-30 | 2021-11-12 | 贵州汉方药业有限公司 | Preparation method of gynecological reconstruction pill |
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| CN106421253A (en) * | 2016-11-23 | 2017-02-22 | 张晓燕 | Traditional Chinese medicine composition for treating uterine bleeding |
| CN113125569A (en) * | 2019-12-30 | 2021-07-16 | 湖南易能生物医药有限公司 | Fingerprint spectrum determination method and quality control method based on Guyinshi material |
| CN113116997A (en) * | 2021-04-30 | 2021-07-16 | 贵州汉方药业有限公司 | Preparation method of storax pills |
| CN113413369A (en) * | 2021-04-30 | 2021-09-21 | 贵州汉方药业有限公司 | Preparation method of flexible rejuvenation pills for children |
| CN113633733A (en) * | 2021-04-30 | 2021-11-12 | 贵州汉方药业有限公司 | Preparation method of gynecological reconstruction pill |
| CN113116997B (en) * | 2021-04-30 | 2022-10-21 | 贵州汉方药业有限公司 | Preparation method of storax pills |
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