CN105796640A - Traditional Chinese medicine composition and preparation with acne treatment function - Google Patents
Traditional Chinese medicine composition and preparation with acne treatment function Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition and preparation with an acne treatment function. The traditional Chinese medicine composition is prepared from radix sophorae flavescentis, radix scutellariae, herba pogostemonis, herba centellae and herba menthae, and preferably prepared from radix sophorae flavescentis extract, radix scutellariae extract, herba pogostemonis extract, herba centellae extract and herba menthae extract. The preparation comprises the traditional Chinese medicine composition with the acne treatment function serving as active ingredients, and further comprises conventional auxiliaries for the preparation. Through reasonable compatibility of radix sophorae flavescentis, radix scutellariae, herba pogostemonis, menthol and herba centellae, the traditional Chinese medicine composition can achieve internal heat reduction, bacterium and inflammation resistance, cytothesis and tissue healing so as to achieve skin regeneration, treatment and repairing are integrated, and effect is good. Besides, the extracts of the traditional Chinese medicinal components are adopted preferably as the raw materials, the content of active ingredients is higher, and effect is better.
Description
Technical field
The present invention relates to Chinese medicine composition and preparation technique field thereof, particularly relate to the Chinese medicine composition and preparation with acne-removal function.
Background technology
Acne is also called acne, comedo, is the most common disease of department of dermatologry, and this is sick occurred frequently in hebetic men and women.Acne is because endocrine more to be increased, sebaceous gland is upset and supersecretion, the epithelial proliferation of hair follicle, make the pilosebaceous unit mouth of pipe blocked, occurring antibacterial to infect subsequently, cause chronic purulent folliculitis, clinical signs is abscess, pimple, abscess, tuberosity etc., mostly occur at positions such as face, chests, produce inflammatory papules, itch or pain.
The generation of acne main with hypersteatosis, pilosebaceous duct blocking, antibacterial infection and inflammatory reaction etc. factor closely related.The level of androgen particularly testosterone in descendant's body that adolesces raises rapidly, promotes that sebaceous gland is grown and produces a large amount of sebum.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia simultaneously, forms horn plug and micropowder thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes produces decomposes sebum and generates free fatty, and chemotactic inflammatory cell and medium, finally induce and increase the weight of inflammatory reaction simultaneously.
The traditional Chinese medical science thinks that acne chief culprit is depression of liver-QI, endocrine disturbance, then brings out heart-fire, lung-heat, damp-heat in the spleen and stomach fumigation cause in face, and Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri are heat clearing and dampness removing medicine, and wherein, the heat of clear part of the body cavity above the diaphragm housing the heart and lungs cardiopulmonary is apt to by Radix Scutellariae；The heat of kind clear middle Jiao of Rhizoma Coptidis, holding concurrently can clearing away heart-fire；Cortex Phellodendri is apt to the heat of the clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and SANHUANG hand in hand, then all damp and hot is removed.Such as: four yellow lotions are by Radix Et Rhizoma Rhei, Radix Scutellariae, each 50 grams of Cortex Phellodendri, sulfur 15 grams, and medicine-feeding grinds to the powder, and sulfur first dissolves with 75% ethanol, then medicine-feeding is added in 500 ml distilled waters and shake up, standby after sealing 1 week.Usage: dip in cotton swab and put on the skin outside medicine, every day 4-6 time, it is adaptable to homeliness type acne and pustule acne, has antiinflammatory to dispel fat effect.Visible, the external application Chinese medicine formula being currently used for treatment acne is more, and majority has certain curative effect, but is all simple function mostly, or dispels fire, or antiinflammatory, it is impossible to fundamentally solves and improves easy having smallpox skin.
Summary of the invention
For drawbacks described above and the problem of prior art, it is an object of the invention to provide the Chinese medicine composition and preparation with acne-removal function.
In order to achieve the above object, the present invention provides following technical scheme:
The invention provides the Chinese medicine composition with acne-removal function, by weight, including Radix Sophorae Flavescentis 1-20 part, Radix Scutellariae 1-10 part, Herba Pogostemonis 1-15 part, Herba Centellae 1-15 part and Herba Menthae 1-10 part.
Preferably, described Chinese medicine composition, by weight, including Radix Sophorae Flavescentis 5-15 part, Radix Scutellariae 2-8 part, Herba Pogostemonis 1-10 part, Herba Centellae 2-10 part and Herba Menthae 3-10 part.
Preferably, described Chinese medicine composition, by weight, including Radix Sophorae Flavescentis 10-15 part, Radix Scutellariae 5-8 part, Herba Pogostemonis 1-5 part, Herba Centellae 5-10 part and Herba Menthae 5-10 part.
It is preferred that technical scheme be that each component in described Chinese medicine composition all adopts corresponding extract.Namely Radix Sophorae Flavescentis adopts Radix Sophorae Flavescentis extract, and Radix Scutellariae adopts Radix Scutellariae extract, and Herba Pogostemonis adopts Radix agastaches extract, and Herba Centellae adopts Herba Centellae extract, and Herba Menthae adopts the extract Mentholum of Herba Menthae.
Further, in described Radix Sophorae Flavescentis extract the mass content of Radix Sophorae Flavescentis total alkaloids more than 20%.Conventional water extraction method is adopted to extract.The mass content of Radix Sophorae Flavescentis total alkaloids is preferably 30%-40%.
Further, in described Radix Scutellariae extract the mass content of baicalin more than 80%.Conventional water extraction method is adopted to extract.The mass content of baicalin is preferably 85%-90%.
Further, in described Herba Centellae extract the mass content of asiaticoside more than 5%.Conventional water extraction method is adopted to extract.The mass content of asiaticoside is preferably 8%-10%.
Further, described Radix agastaches extract is patchouli oil.Vapor distillation or supercritical extraction is adopted to obtain.
Further, described Folium Menthae extract is Mentholum.Vapor distillation or supercritical extraction is adopted to obtain.
The Chinese medicine composition of the present invention is by composite for the mixing of each raw material.Can be pulverous mixture, add water or the binding agent such as Mel is mixed to get pastel, smear to affected part.Can also be block mixture, the extracting solution that follow-up employing routine decocting obtains, directly smear to affected part after being concentrated into finite concentration.When certainly preferably employing the extract of each component as raw material, as long as each component extract is mixed.
Present invention also offers the preparation with acne-removal function, including the above-mentioned Chinese medicine composition with acne-removal function as active constituents of medicine.
Further, in described preparation, the weight/mass percentage composition of Chinese medicine composition is 0.1%-15%.
Preferably, in described preparation, the weight/mass percentage composition of Chinese medicine composition is 1%-10%.
Preferably, in described preparation, the weight/mass percentage composition of Chinese medicine composition is 2%-5%.
Preferably, in described preparation, the weight/mass percentage composition of Chinese medicine composition is 3%.
Further, in described preparation, also include the customary adjuvant of preparation.
Further, described preparation is externally applied formulation.As, water preparation, emulsion agent, unguentum, cream or gel etc..
In the Chinese medicine composition of the present invention, the property of medicine of each component is as follows:
Radix Sophorae Flavescentis, bitter in the mouth；Cold in nature.Enter liver, kidney, large intestine, small intestine meridian.Effect: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, eczema, eczema, skin pruritus.
Radix Scutellariae, bitter in the mouth, cold in nature.Enter the heart, lung, gallbladder, large intestine channel.Function cures mainly: removing the relative excess fire, dehumidifying heat, hemostasis.Control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, conjunctival congestion and swelling pain, carbuncle furuncle.
Herba Pogostemonis, acrid in the mouth；Slightly warm in nature.Return spleen；Stomach；Lung meridian.Effect: eliminating turbid pathogen with aromatics, whet the appetite preventing or arresting vomiting, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer asthenia, uncomfortable in chest does not relax, and cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
Herba Centellae, slightly sweet flavor is pungent；Cold in nature.Enter the heart, lung, spleen, stomach, the large intestine Five Classics.Effect: clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, anti-inflammation, diuretic and spleen, hemostasis.
Mentholum, acrid in the mouth, cool in nature, nontoxic.There is effect of dispelling wind, heat clearing away.Cure mainly the symptoms such as anemopyretic cold, headache, conjunctival congestion, laryngopharynx swelling and pain, toothache, skin pruritus.
In the Chinese medicine composition of the present invention, containing matrine in Radix Sophorae Flavescentis, matrine extract is that the dry root by leguminous plant Radix Sophorae Flavescentis prepares alkaloid compound through organic solvent extraction such as ethanol.Matrine has clearing away heat-damp and promoting diuresis, diuresis jaundice eliminating, removing toxic substances, improves pathologic hepatitis symptom and sign, effect of reducing enzyme levels, it is suppressed that the duplication of hepatitis B HBeAg, still has anticancer and antiarrhythmic effect.
Containing baicalin in Radix Scutellariae, baicalin is to extract a kind of flavone compound separated from scutellariae,radix, has significant biological activity, has antibacterial, diuresis, antiinflammatory, resistance state and spasmolysis, and has the physiological potencies such as stronger antitumor response.Baicalin can also absorb ultraviolet, scavenging activated oxygen, can suppress again melanic generation.
Herba Centellae can be compacted epidermis and corium coupling part, skin can be made to limber up, contribute to solving cutis laxa phenomenon (especially mother in puerperal), make skin smooth flexible；Helping to promote that in skin corium, collagen protein is formed, and makes fibrin regenerate, reconnect is got up, and makes skin reach smooth effect of compacting, and also assists in impaired organization healing and consolidation skin.
Containing Herba Pogostemonis Volatile oil in Herba Pogostemonis, Herba Pogostemonis Volatile oil extract is that Herba Pogostemonis Pogostemoncablin (Blanco) Benth refines the volatile flavor extracted by steam distillation, squeezing and pressing method, cold-maceration or solvent extraction method.There is skin care and treat dermopathic effect；Anti-inflammation, it is possible to promote cell regeneration, is especially suitable for treatment acne, and it is very effective that the germ of laceration of skin, eczema, tinea pedis etc infects disease, some skin allergy and dandruff etc..
Mentholum system is extracted by the leaf of Herba Menthae and stem, and white crystal, for the main component in Herba Menthae and lavender quintessence oil.In the world, India is main natural Herba Menthae manufacturing country.Mentholum and racementhol can be employed as the odorant of toothpaste, perfume, beverage and confection etc..Being pharmaceutically used as excitants, act on skin or mucosa, have refrigerant itching-relieving action.
Above-mentioned sophora flavescens ait, Radix Scutellariae, Herba Pogostemonis, Mentholum and Herba Centellae are carried out reasonable compatibility by the Chinese medicine composition of the present invention, make to be provided simultaneously with to dispel the function of fire, antimicrobial antiphlogistic, and cell regeneration, organization healing, and then realize the function of skin regeneration, integrate treatment and repair, effective.And it is preferred that the extract of each Chinese medicinal components is as raw material, active ingredient of Chinese herbs is higher, effect is more preferably.
Detailed description of the invention
Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
The Chinese medicine composition with acne-removal function of the present embodiment 1, by weight, including Radix Sophorae Flavescentis 20 parts, Radix Scutellariae 10 parts, Herba Pogostemonis 15 parts, Herba Centellae 15 parts and Mentholum 10 parts.
In the present embodiment 1, each raw material of Chinese medicine adopts powder body, each Chinese traditional powder is mixed and obtains Chinese medicine composition.During use, with the edible material such as water or Mel as binding agent, it is mixed to get pastel with mixed powder, this pastel is smeared to affected part.
Embodiment 2
The Chinese medicine composition with acne-removal function of the present embodiment 2, by weight, including Radix Sophorae Flavescentis 20 parts, Radix Scutellariae 10 parts, Herba Pogostemonis 15 parts, Herba Centellae 15 parts and Mentholum 10 parts.
In the present embodiment 2, each raw material of Chinese medicine adopts bulk.During use, block raw material of Chinese medicine is adopted conventional decocting, more directly smear to affected part after the Decoction obtained is concentrated into finite concentration.
Embodiment 3
The Chinese medicine composition with acne-removal function of the present embodiment 3, by weight, including Radix Sophorae Flavescentis extract 10-15 part, Radix Scutellariae extract 5-8 part, Radix agastaches extract 1-5 part, Herba Centellae extract 5-10 part and Folium Menthae extract 5-10 part.
In the Chinese medicine composition of the present embodiment 3, each raw material all adopts corresponding extract, and in extract, active component is more, and in each raw extract, the synergistic action effect of active component is more preferably.
Wherein, in described Radix Sophorae Flavescentis extract the mass content of Radix Sophorae Flavescentis total alkaloids more than 20%；Conventional water extraction method is adopted to extract.In described Radix Scutellariae extract, the mass content of baicalin is more than 80%；Conventional water extraction method is adopted to extract.In described Herba Centellae extract, the mass content of asiaticoside is more than 5%；Conventional water extraction method is adopted to extract.Described Radix agastaches extract is patchouli oil；Vapor distillation or supercritical extraction is adopted to obtain.Described Folium Menthae extract is Oleum menthae；Vapor distillation or supercritical extraction is adopted to obtain.
Embodiment 4
The Chinese medicine composition with acne-removal function of the present embodiment 3, by weight, including Radix Sophorae Flavescentis extract 5 parts, Radix Scutellariae extract 1 part, patchouli oil 3 parts, Herba Centellae extract 2 parts, Mentholum 5 parts.
Wherein, in Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is 30%-40%.In Radix Scutellariae extract, the mass content of baicalin is 85%-90%.In Herba Centellae extract, the mass content of asiaticoside is 8%-10%.
Embodiment 5
The Chinese medicine composition with acne-removal function of the present embodiment 5, by weight, including Radix Sophorae Flavescentis extract 10 parts, Radix Scutellariae extract 3 parts, patchouli oil 3 parts, Herba Centellae extract 1 part, Mentholum 5 parts.
Wherein, in Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is 30%-40%.In Radix Scutellariae extract, the mass content of baicalin is 85%-90%.In Herba Centellae extract, the mass content of asiaticoside is 8%-10%.
Embodiment 6
The Chinese medicine composition with acne-removal function of the present embodiment 6, by weight, including Radix Sophorae Flavescentis extract 1 part, Radix Scutellariae extract 10 parts, patchouli oil 1 part, Herba Centellae extract 5 parts, Mentholum 10 parts.
Wherein, in Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is 30%-40%.In Radix Scutellariae extract, the mass content of baicalin is 85%-90%.In Herba Centellae extract, the mass content of asiaticoside is 8%-10%.
Embodiment 7
The Chinese medicine composition with acne-removal function of the present embodiment 7, by weight, including Radix Sophorae Flavescentis extract 15 parts, Radix Scutellariae extract 5 parts, patchouli oil 3 parts, Herba Centellae extract 2 parts, Mentholum 5 parts.
Wherein, in Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is 30%-40%.In Radix Scutellariae extract, the mass content of baicalin is 85%-90%.In Herba Centellae extract, the mass content of asiaticoside is 8%-10%.
Embodiment 8
The Chinese medicine composition with acne-removal function of the present embodiment 8, by weight, including Radix Sophorae Flavescentis extract 10 parts, Radix Scutellariae extract 2 parts, patchouli oil 3 parts, Herba Centellae extract 10 parts, Mentholum 3 parts.
Wherein, in Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is 30%-40%.In Radix Scutellariae extract, the mass content of baicalin is 85%-90%.In Herba Centellae extract, the mass content of asiaticoside is 8%-10%.
Embodiment 9
The Chinese medicine composition with acne-removal function of the present embodiment 9, by weight, including Radix Sophorae Flavescentis extract 15 parts, Radix Scutellariae extract 5 parts, patchouli oil 1 part, Herba Centellae extract 10 parts, Mentholum 3 parts.
Wherein, in Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is 30%-40%.In Radix Scutellariae extract, the mass content of baicalin is 85%-90%.In Herba Centellae extract, the mass content of asiaticoside is 8%-10%.
Embodiment 10
The present embodiment 10 is the preparation with acne-removal function, including the above-mentioned Chinese medicine composition with acne-removal function as active constituents of medicine.Chinese medicine composition weight/mass percentage composition in described preparation is determined according to actual preparation type.Specifically, in described preparation, the weight/mass percentage composition of Chinese medicine composition can be 0.1%-15%.
In the preparation with acne-removal function of the present embodiment 10, except including the above-mentioned Chinese medicine composition beyond the region of objective existence with acne-removal function of above-mentioned active constituents of medicine, also include the customary adjuvant of preparation, to be made as corresponding dosage form.
Specifically, described preparation preferably employs externally applied formulation, e.g., and water preparation, emulsion agent, unguentum, cream or gel etc..
Below for conventional externally applied formulation gel and cream, provide the concrete gel with acne-removal function and cream.
Having the gel of acne-removal function, including above-mentioned Chinese medicine composition and other customary adjuvant, wherein, customary adjuvant includes Acritamer 940, propylene glycol, laurocapram, triethanolamine, tween 80 and water etc..
Concrete formula is as shown in table 1 below.
Table 1
The preparation method of the above-mentioned gel with acne-removal function adopts existing customary preparation methods.Specific as follows: Acritamer 940 to be spread in appropriate distilled water, fully swelling, add glycerol, propylene glycol 100g, laurocapram grinds and makes moistening, adding triethanolamine and grind to form clear gel substrate, water-bath is to 70 DEG C. take above-mentioned Chinese medicine composition 20g, ethanol 50g, propylene glycol 100g, tween 80 Hybrid Heating adds appropriate preservative (methyl hydroxybenzoate+ethyl ester), joins in substrate by above-mentioned medicinal liquid after dissolving, slow quickening stirs, add distilled water to 1000g, continue to stir, obtain gel.
There is the cream of acne-removal function, including aforesaid Chinese medicine composition and other customary adjuvant.Customary adjuvant adopts the adjuvant that this area routine adopts, and preparation technology is also adopted by common process.The present embodiment gives the cream 1 of concrete formula, cream 2 and cream 3, shown in concrete composition and consumption such as table 2 below and table 3.
The formula of table 2 cream 1
The preparation technology of cream 1 is: is mixed homogeneously with the Radix agastaches extract (patchouli oil) of Chinese medicine composition, Mentholum by oil-phase component, is heated to about 75 DEG C and makes oil phase.All the other extracts of Chinese medicine composition are dissolved in alcohol mixed with water uniformly, be heated to about 75 DEG C and make aqueous phase.Oil phase, aqueous phase all add emulsifying in vacuum homogenizer, are cooled to 45 DEG C, and adding preservative agent stirs, can canned finished product.
The formula of table 3 cream 2
The preparation technology of cream 2 is identical with the preparation technology of cream 1.
The formula of cream 3 is the same with the formula of cream 2, as long as the Chinese medicine composition of embodiment 8 replaces with the Chinese medicine composition of embodiment 9.Preparation technology is identical with the preparation technology of cream 1.
In the present invention, for above-mentioned gel 1, gel 2 and gel 3, and cream 1, cream 2 and cream 3, carry out evaluating drug effect.Evaluating drug effect adopts mice caused by dimethylbenzene xylene ear swelling test, tests as follows:
1. laboratory animal: kunming mice, body weight 18-22g, male and female half and half are provided by Jun Ke institute institute, animal productiong credit number: SCXK-007.
2. experimental technique:
Take kunming mice 80, be randomly divided into 8 groups, male and female half and half.By gel 1, gel 2 and gel 3, and cream 1, cream 2 and cream 3, it is coated with relative medicine to respectively the wealthy interior outside of mouse right ear.Arranging two matched groups, first matched group is Normal group simultaneously, is do not smear any medicine.Second matched group is the matched group smearing existing hydrocortisone group.Smearing method is: 1 time/d, continuous 3d, after last is administered 0.5h, cuts a hole auricle with card punch and weighs, compare with left ear after every the mouse right ear back of the body uniform application dimethylbenzene 0.01mL, 4h, and analytical balance is weighed.The weight difference of ears is swelling.Result is in Table 4.
The impact (n=10) on mice auricle swelling degree of the table 4 each example set
Model group compares with normal group, △ △ P < 0.01；Compare with model group, * * P < 0.01.
Test result indicate that, Chinese medicine composition and the corresponding preparation of the present invention all show good antiphlogistic effects.
The above; being only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, any those familiar with the art is in the technical scope that the invention discloses; change can be readily occurred in or replace, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should described be as the criterion with scope of the claims.
Claims (10)
1. there is the Chinese medicine composition of acne-removal function, it is characterised in that by weight, including Radix Sophorae Flavescentis 1-20 part, Radix Scutellariae 1-10 part, Herba Pogostemonis 1-15 part, Herba Centellae 1-15 part and Herba Menthae 1-10 part.
2. the Chinese medicine composition with acne-removal function according to claim 1, it is characterised in that described Chinese medicine composition, by weight, including Radix Sophorae Flavescentis 5-15 part, Radix Scutellariae 2-8 part, Herba Pogostemonis 1-10 part, Herba Centellae 2-10 part and Herba Menthae 3-10 part.
3. the Chinese medicine composition with acne-removal function according to claim 1, it is characterised in that described Chinese medicine composition, by weight, including Radix Sophorae Flavescentis 10-15 part, Radix Scutellariae 5-8 part, Herba Pogostemonis 1-5 part, Herba Centellae 5-10 part and Herba Menthae 5-10 part.
4. the Chinese medicine composition with acne-removal function according to any one of claim 1 to 3, it is characterised in that each component in described Chinese medicine composition all adopts corresponding extract；Namely Radix Sophorae Flavescentis adopts Radix Sophorae Flavescentis extract, and Radix Scutellariae adopts Radix Scutellariae extract, and Herba Pogostemonis adopts Radix agastaches extract, and Herba Centellae adopts Herba Centellae extract, and Herba Menthae adopts the extract Mentholum of Herba Menthae.
5. the Chinese medicine composition with acne-removal function according to claim 4, it is characterised in that in described Radix Sophorae Flavescentis extract, the mass content of Radix Sophorae Flavescentis total alkaloids is more than 20%；In described Radix Scutellariae extract, the mass content of baicalin is more than 80%；In described Herba Centellae extract, the mass content of asiaticoside is more than 5%；Described Radix agastaches extract is patchouli oil；Described Folium Menthae extract is Mentholum.
6. there is the preparation of acne-removal function, it is characterised in that include as the Chinese medicine composition with acne-removal function according to any one of the claims 1 to 5 of active constituents of medicine.
7. the preparation with acne-removal function according to claim 6, it is characterised in that in described preparation, the weight/mass percentage composition of Chinese medicine composition is 0.1%-15%.
8. the preparation with acne-removal function according to claim 7, it is characterised in that in described preparation, the weight/mass percentage composition of Chinese medicine composition is 1%-10%.
9. having the preparation of acne-removal function according to claim 7, it is characterised in that in described preparation, the weight/mass percentage composition of Chinese medicine composition is 2%-5%.
10. the preparation with acne-removal function according to any one of claim 6 to 9, it is characterised in that described preparation is externally applied formulation.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726689A (en) * | 2016-12-24 | 2017-05-31 | 叶宗瑞 | It is a kind of to prevent and treat face cream of acne and preparation method thereof |
| CN109260119A (en) * | 2018-11-27 | 2019-01-25 | 大连民族大学 | A kind of anti-acne repairs facial mask and preparation method thereof |
| CN112494575A (en) * | 2020-12-29 | 2021-03-16 | 管晓坤 | Traditional Chinese medicine gel with acne removing effect and preparation method thereof |
| CN116850340A (en) * | 2023-08-18 | 2023-10-10 | 哈尔滨乾佰纳生物药业有限公司 | Recombinant collagen liposome dressing and preparation method and application method thereof |
| CN116850340B (en) * | 2023-08-18 | 2024-06-04 | 哈尔滨乾佰纳生物药业有限公司 | Recombinant collagen liposome dressing and preparation method and application method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584746A (en) * | 2008-05-22 | 2009-11-25 | 毛玉麟 | Medicine composition for healing wounds and preparation method thereof |
| CN102397405A (en) * | 2011-11-28 | 2012-04-04 | 西北农林科技大学 | Compound bergamot oil nano-emulsion composition and preparation method thereof |
| CN105079186A (en) * | 2015-08-21 | 2015-11-25 | 中日友好医院 | Traditional Chinese medicine composition for externally treating skin rash, and preparation method and application of traditional Chinese medicine composition |
| CN105476914A (en) * | 2015-12-21 | 2016-04-13 | 太仓张根木生物科技有限公司 | Acne-removing, water-replenishing and moisture-preserving lotion |
| CN105796424A (en) * | 2016-03-31 | 2016-07-27 | 广东食品药品职业学院 | Acne-removing composition and application thereof to cosmetics |
-
2016
- 2016-04-19 CN CN201610244587.XA patent/CN105796640A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584746A (en) * | 2008-05-22 | 2009-11-25 | 毛玉麟 | Medicine composition for healing wounds and preparation method thereof |
| CN102397405A (en) * | 2011-11-28 | 2012-04-04 | 西北农林科技大学 | Compound bergamot oil nano-emulsion composition and preparation method thereof |
| CN105079186A (en) * | 2015-08-21 | 2015-11-25 | 中日友好医院 | Traditional Chinese medicine composition for externally treating skin rash, and preparation method and application of traditional Chinese medicine composition |
| CN105476914A (en) * | 2015-12-21 | 2016-04-13 | 太仓张根木生物科技有限公司 | Acne-removing, water-replenishing and moisture-preserving lotion |
| CN105796424A (en) * | 2016-03-31 | 2016-07-27 | 广东食品药品职业学院 | Acne-removing composition and application thereof to cosmetics |
Non-Patent Citations (1)
| Title |
|---|
| 赵华英: "《生药学》", 30 April 2005, 山东大学出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726689A (en) * | 2016-12-24 | 2017-05-31 | 叶宗瑞 | It is a kind of to prevent and treat face cream of acne and preparation method thereof |
| CN109260119A (en) * | 2018-11-27 | 2019-01-25 | 大连民族大学 | A kind of anti-acne repairs facial mask and preparation method thereof |
| CN112494575A (en) * | 2020-12-29 | 2021-03-16 | 管晓坤 | Traditional Chinese medicine gel with acne removing effect and preparation method thereof |
| CN116850340A (en) * | 2023-08-18 | 2023-10-10 | 哈尔滨乾佰纳生物药业有限公司 | Recombinant collagen liposome dressing and preparation method and application method thereof |
| CN116850340B (en) * | 2023-08-18 | 2024-06-04 | 哈尔滨乾佰纳生物药业有限公司 | Recombinant collagen liposome dressing and preparation method and application method thereof |
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