CN101804188B - Composition for controlling atrichia and manufacture method thereof - Google Patents
Composition for controlling atrichia and manufacture method thereof Download PDFInfo
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- CN101804188B CN101804188B CN2010101475476A CN201010147547A CN101804188B CN 101804188 B CN101804188 B CN 101804188B CN 2010101475476 A CN2010101475476 A CN 2010101475476A CN 201010147547 A CN201010147547 A CN 201010147547A CN 101804188 B CN101804188 B CN 101804188B
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Abstract
The invention provides a composition for controlling atrichia. Raw materials of the composition comprise the following ingredients: angelica sinensis, hurricane lamp, salvia miltiorrhiza bge, radix sophorae flavescentis, cortex lycii radicis, rhizoma zingiberis, rhizoma drynariae, notopterygium root, pawpaw, rhizoma ligustici wallichii, common dodder, rhizoma gastrodiae, ginseng, lopseed, radix paeoniae alba and spatholobus stem. The composition for controlling the atrichia of the invention can enhance the scalp blood circulation, can particularly and effectively inhabit the sebaceous gland exudation, can eliminate the scalp grease, can improve the hair follicle growth environment, and can promote the discharge of decay hair. The composition for controlling the atrichia contains a certain number of hair growing and developing ingredients, and the connection effect in the hair growing link can be realized on the basis of fast atrichia prevention.
Description
Technical field
The present invention relates to cosmetic field.More particularly, relate to a kind of compositions that is used to control alopecia, also relate to the manufacture method of above-mentioned composition.
Background technology
Alopecia and be born in the male because of alopecia causes bald pilosity is a kind of commonplace phenomenon.Its reason more complicated it is believed that heredity is a key factor.In addition, androgen is too much, and psychentonia, emotional instability etc. all are considered to the reason of its generation.
Hair is the part of tissue, is pushed to skin surface and grows after hair follicle inner cell division.Therefore alopecia phenomenon and hair follicle nutrition, metabolism situation have direct relation.In order to improve alopecia and to promote the growth of hair.The method of external reactive protein with the nourishing hair follicle arranged in the prior art, but effect is not remarkable.In addition, also there are some to spread, but do not form product truly in prescription among the people in China.
Especially, seborrheic alopecia is global problem at present.The present inventor is devoted to improve the special cosmetics of alopecia and the research of medicine from nineteen sixty-eight.By China's tradition is combined through proved recipe and modern science and technology, proposed to improve the 101 HAIR BREEDING AGENT of seborrheic alopecia first in 1986, and obtained significant effect.Over twenties years, 101 educate and send out a product and formed series and enjoy a good market both at home and abroad, and repeatedly prize-winning in the world.Hair follicle activates liquid (trade name: ZHANGGUANG 101 hair follicle nourishing liquid) obtained patent of invention, certificate number in 2005: No. 219083.The patent No.: ZL02155404.8 international monopoly Main classification number: A61K35/78 Granted publication day: on July 27th, 2005.Obtained good effect.
But, also have the demand of further enriching the kind of this series products and improving this series products effect.
Summary of the invention
The inventor finds simple hair loss patient to be used the generating hair product, occur repeatedly easily, especially use the initial stage at the generating hair product, growth along with New Development, original alopecia speed is not slowed down, cause good hair growth promoting effect to be covered, cause the illusion of hair growth promoting DeGrain on directly perceived by continuous alopecia.Have a strong impact on patient's confidence.
At this technical problem, the invention provides a kind of compositions that can control the control alopecia of alopecia at short notice.
The present invention also provides a kind of preparation of compositions method of controlling alopecia.
Technical scheme of the present invention comprises:
(1). a kind of compositions of controlling alopecia, its raw material comprises following Chinese medicine ingredients:
Radix Angelicae Sinensis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, Cortex Lycii, Rhizoma Zingiberis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Fructus Chaenomelis, Rhizoma Chuanxiong, Semen Cuscutae, Rhizoma Gastrodiae, Radix Ginseng, Herba speranskiae tuberculatae, the Radix Paeoniae Alba and Caulis Spatholobi.
(2). according to the compositions of the described control alopecia of technical scheme (1), wherein, be somebody's turn to do the compositions of controlling alopecia with respect to 100 weight portions, as raw material, the weight portion of described every kind of raw material is not less than 0.1 weight portion, preferably all drops within the 0.1-5 weight portion.
(3). according to the compositions of technical scheme (1) or (2) described control alopecia, wherein, the compositions of control alopecia comprises the Chinese medicine extraction liquid of described raw material, and wherein, described Chinese medicine extraction liquid is described raw material to be extracted and the Chinese medicine extraction liquid that obtains with the extraction solvent.
(4). according to the compositions of the described control alopecia of technical scheme (3), wherein, described extraction solvent contains water, alcohols and/or the ketones solvent that meets the medicine regulation.
(5). according to the compositions of technical scheme (3) or (4) described control alopecia, wherein, adopt cold extraction and/or boil the mode of putting forward, with extracting solvent described raw material is extracted, obtain this Chinese medicine extraction liquid, for example, use and to boil the method for putting forward and extract: boil at twice with the ethanol water of 50-75 weight % and carry described raw material, boil the time of carrying is 1-3 hour at every turn, and temperature is 70-90 ℃.
(6). according to the compositions of technical scheme (1)～(5) each described control alopecia, wherein, further contain additive, this additive is selected from by in the following group of forming one or more: diluent, wetting agent, wetting agent, solubilizing agent, thickening agent, spice, dyestuff, pH regulator agent, surfactant, antiseptic, antibacterial, stabilizing agent, emulsifying agent, buffer agent, excipient and their mixture.
(7). according to the compositions of technical scheme (1)～(6) each described control alopecia, wherein, the compositions of described control alopecia is a solution, for example is washing liquid, spray or dew liquid, or semi-solid form, for example unguentum, gel, cream, Emulsion, patch or wet tissue.
(8). the preparation of compositions method of technical scheme (1) or (2) described control alopecia wherein, may further comprise the steps:
With extracting solvent described raw material is extracted, obtain Chinese medicine extraction liquid.
(9). according to the described preparation method of technical scheme (8), wherein, with extracting solvent described raw material is extracted the employing cold extraction and/or boils the mode of putting forward, for example, use is boiled the method for putting forward and is extracted: boil at twice with the ethanol water of 50-75 weight % and carry described raw material, boil the time of carrying is 1-3 hour at every turn, and temperature is 70-90 ℃.
(10). each the compositions of control alopecia of technical scheme (1)～(7) is used for controlling the medicine of alopecia or the application of articles for daily use in preparation.
The compositions of control alopecia of the present invention can effectively be controlled alopecia at short notice.
The compositions of control alopecia of the present invention can increase the scalp blood circulation, particularly can effectively suppress smegma, dispels the scalp oils and fats, improves the hair follicle growth environment, promotes the decline hair to discharge.And contain a certain amount of generating hair composition, on the basis of rapid anti-avulsion, the hair growth promoting link is played the linking effect.
The compositions of preferred control alopecia of the present invention preferably is mainly used in the product at alopeciaing therapeutic initial stage, can control alopecia at short notice, for the hair growth promoting of middle and late stage provides good condition in advance.
The specific embodiment
Aforementioned and other features of the present invention will will more fully be described hereinafter, and particularly point out in the claims, following description elaborates illustrative embodiments more of the present invention, but, these embodiments are just represented the operable several different modes of principle of the present invention.In conjunction with preferred embodiment following, other advantages of the present invention and feature are clearly to those skilled in the art.
According to one embodiment of the present invention, a kind of compositions of controlling alopecia is provided, its Chinese medicine raw material packet is drawn together following composition:
Radix Angelicae Sinensis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, Cortex Lycii, Rhizoma Zingiberis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Fructus Chaenomelis, Rhizoma Chuanxiong, Semen Cuscutae, Rhizoma Gastrodiae, Radix Ginseng, Herba speranskiae tuberculatae, the Radix Paeoniae Alba and Caulis Spatholobi.
The Latin formal name used at school of each raw material of Chinese medicine and its effect and effect are listed in the table below in 1:
The Latin formal name used at school of table 1 raw material of Chinese medicine and its effect and effect
| The Chinese formal name used at school | The Latin formal name used at school | Effect and effect |
| Radix Angelicae Sinensis | Angelica sinensis (Oliv.) Diels | Enrich blood and invigorate blood circulation, loosening bowel to relieve constipation is used for blood deficiency and yellow complexion, rheumatic arthralgia, injury from falling down, carbuncle skin infection |
| Radix Saposhnikoviae | Saposhnikovia divaricata (Turcz.) Schisck. | Inducing diaphoresis to dispel wind wins wet relieving convulsion.Rheumatic arthralgia, rheumatism pruritus, tetanus. |
| Radix Salviae Miltiorrhizae | Salvia miltiorrhiza Bge. | Promoting blood circulation to restore menstrual flow, the effect of blood stasis removing analgesic are arranged |
| Radix Sophorae Flavescentis | Sophora flavescens Ait. | Heat clearing away, damp eliminating, detoxifcation.Be used for eczema, furuncle, venom. |
| Cortex Lycii | Lycium chinense Mill. | Removing heat from blood removes and steams the lung heat clearing pathogenic fire reducing.Be used for deficiency of YIN hectic fever |
| Rhizoma Zingiberis | Zingiber officinalis (Willd.) Rosc, | The Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, cold extremities faint pulse |
| Rhizoma Drynariae | Drynaria fortunei (Kunze) J.Sm. | The kidney invigorating bone strengthening continues and hinders pain relieving, is used for lumbago due to renal deficiency, and falling winks frustrates muscles and bones folding wound, external treatment alopecia areata, vitiligo. |
| Rhizoma Et Radix Notopterygii | Notopterygium incisum Ting ex H.T.Chang | Cold expelling, dispel the wind, removing damp and stopping pain |
| Fructus Chaenomelis | Chaenomeles speciosa (Sweet) Nakai | Cold expelling, dispel the wind, dehumidifying, pain relieving |
| Rhizoma Chuanxiong | Ligusticum chuanxiong Hort. | Blood-activating and qi-promoting, wind-expelling pain-stopping ， WEIJIA stomachache, costa sternales twinge, tumbling and swelling, headache, rheumatic arthralgia. |
| Semen Cuscutae | Cuscuta chinensis Lam. | Nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal. |
| Rhizoma Gastrodiae | Gastrodia elata Bl. | The suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.It is dizzy to be used to have a headache, numb limbs and tense tendons. |
| Radix Ginseng | Panax ginseng C.A.Mey | Strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind effect admittedly |
| Herba speranskiae tuberculatae | Speranskia tuberculata (Bunge) Baill | Dispel the wind dehumidifying, Shujin, promoting blood circulation and stopping pain |
| The Radix Paeoniae Alba | Paeonia lactiflora Pall. | The suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, it is dizzy to be used to have a headache, costalgia, stomachache, limb pain twin, blood deficiency and yellow complexion |
| Caulis Spatholobi | Spatholobus suberectus Dunn | Enrich blood, invigorate blood circulation, collateral dredging is used for blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia. |
The present inventor is surprised to find above 16 kinds of Chinese medicines for having very excellent synergism in effective control alopecia through secular concentrating on studies, and reaches the effect of controlling alopecia effectively, at short notice.
A preferred embodiment of the invention, the compositions of control alopecia, wherein, should control the compositions of alopecia with respect to 100 weight portions, the ratio of above-mentioned each raw material is in weight ratio, and preferably the weight portion of each raw material is not less than 0.1 weight portion, more preferably all drops within the 0.1-5 weight portion, the ratio of each raw material can be adjusted, can the very big effect that influences said composition.This ratio is the 0.2-2 weight portion more preferably.If the ratio of each raw material in above preferred range the time, both can guarantee the effect of product, can further control cost again, so be preferred.
The high limit of each proportion does not also mean that each raw material can only use below the high limit at this, just more than this height is limit, because the newly-increased effect that increase brought of raw material active component is not remarkable, taking cost into account uneconomical, so raw material weight proportion set forth above is a preferred range, is not necessary.
According to another kind of preferred implementation of the present invention, the method preparation of the compositions of control alopecia by may further comprise the steps: with extracting solvent described raw material is extracted, obtain Chinese medicine extraction liquid.
Wherein extract solvent and be preferably water, alcohols and/or the ketones solvent that meets the medicine regulation, be preferably alcohol, water alcohol, glycerol and/or acetone etc. especially, further be preferably alcohol or water alcohol especially, ethanol water most preferably, such as the ethanol water of 30-90 weight %, the ethanol water of preferred 50-75 weight %.Also can use one or more the mixture in the above various extraction solvent.
According to another kind of preferred implementation of the present invention, the preparation of compositions method of this control alopecia can be the Chinese medicine extraction method of existing any routine, can be that cold extraction and/or boil such as puies forward at method.The inventor is in order to keep drug effect better, and this extracting method preferably includes following steps:
-take by weighing needed raw material of Chinese medicine according to the relative weight ratio of above-mentioned raw materials;
-one or more times,, on the solvent use amount, be standard with complete submergence Chinese crude drug with extracting in their immersion extraction solvents, the amount of solvent is unimportant, as long as the effective ingredient in the Chinese crude drug fully can be extracted.Preferably, the ratio of extracting the gross weight of the gross weight of solvent and above-mentioned raw material of Chinese medicine to be extracted is preferably 1～5: 1, more preferably 2～12: 1, consider more preferably 2～3: 1 from cost savings.Above ratio is 1～5: in the time of in 1 scope, can fully extract the effective ingredient in each raw material of Chinese medicine, institute is so that preparation method is simple and the saving cost.
-filter, obtain the extracting solution that filtrate is Chinese medicine,
If-this Chinese medicine extraction liquid that obtains can be directly as the compositions of controlling alopecia from measuring the weight proportion requirement of the compositions that satisfies above-mentioned control alopecia.
If necessary, also described Chinese medicine extraction liquid can be mixed the compositions of controlled alopecia with other components.
Wherein, for the situation of using cold extraction, soak time was preferably 12 hours-30 days, preferred 1-15 days, further preferred 2-10 days, stirred once, and helped fully extracting Effective Components of Chinese Herb in preferred every 10-12 hour.Boil situation about putting forward for use, boil the time of carrying to be preferably 0.5-10 hour, preferred 1-8 hour, further preferred 2-4 hour, can boil through one or many and carry.Also can use cold extraction and boil and put forward the method that combines and extract.The upper limit of said extracted time just from save time, cost considers that the extraction time of further extending can not improved the effect of its extract especially significantly.
Preparation of compositions method as the control alopecia of preferred embodiment of the present invention, use is boiled the method for putting forward and is extracted described Chinese medicine extraction liquid, preferably, boil at twice with the ethanol water of 50-75 weight % and to carry described raw material of Chinese medicine, boil the time of carrying is preferably 1-3 hour at every turn, and temperature is preferably 70-90 ℃.
For employed solvent types and amount in the leaching process, can adjust as required, as long as the time with other combined hybrid, can make in the final compositions with respect to this control alopecia of 100 weight portions, get final product as the ratio of the above-mentioned raw material of Chinese medicine of raw material.
The above compositions of Shuo Ming control alopecia, each component that contains as above is an active ingredient compositions, can make various dosage forms and be used for external, it can be liquid form, as solution, can make washing liquid, spray, dew liquid etc. particularly, perhaps semi-solid form is as unguentum, gel, cream, Emulsion, patch, wet tissue etc.
Adopt prior art, those skilled in the art can adopt various method in common, prepare the compositions of the control alopecia of different dosage form.In order to be used for local the use easily, in compositions, can also add the additive that can be used in cosmetics or the pharmaceutical preparation, this additive be selected from following one or more: diluent, wetting agent, wetting agent, solubilizing agent, thickening agent, spice, dyestuff, pH regulator agent, surfactant (anion surfactant, cationic surfactant or amphoteric surfactant), antiseptic, antibacterial, stabilizing agent, emulsifying agent, buffer agent and other are usually used in excipient in cosmetics or the pharmaceutical preparation and their mixture.
Wetting agent, be preferably selected from polyhydric alcohol, saccharide, amino acids or their mixture etc., the object lesson of polyhydric alcohol is preferably: glycerol (being glycerol), propylene glycol, sorbitol, dipropylene glycol, 1,3 butylene glycol, Polyethylene Glycol etc. are preferably glycerol especially; If contain wetting agent, the compositions based on the control alopecia of the present invention of 100 weight portions preferably contains wetting agent 3-7 weight portion, and preferred 4-6 weight portion especially preferably contains 5 parts of wetting agents.
This pH regulator agent is used in the pH regulator agent, and the pH value and the skin of the compositions of control alopecia of the present invention are close, and such as using alkali metal hydroxides such as potassium hydroxide, sodium hydroxide, preferably pH value is adjusted to 6.8～7.3;
Antiseptic: be preferably selected from imidazolidinyl urea, hydantoin, isothiazolone, parabens (p-Hydroxybenzoate), quaternary ammonium salt or iodo propinyl carbamic acid fourth fat (IPBC) etc.; If contain antiseptic, the compositions based on the control alopecia of the present invention of 100 weight portions preferably contains antiseptic 0.1-0.3 weight portion, and preferred 0.25 weight portion can add according to the addition that antiseptic itself requires.
Thickening agent: (for example: the cross linked polymer of polyvinyl methyl ethermaleic anhydride/acrylic acid methyl ester. and decadinene) etc. be preferably selected from tragacanth gum, pectin, arabic gum, alginate, cellulose derivative or acrylic acid series polymeric compounds.If contain thickening agent, the compositions based on the control alopecia of the present invention of 100 weight portions preferably contains thickening agent 12-17 weight portion, preferred 14-16 weight portion, and preferred especially 15 weight portions can add according to the addition of thickening agent requirement itself.
Wherein, diluent is preferably selected from water, alcohol or their mixture etc., is preferably water and alcoholic acid mixture, is preferably the ethanol water of 20-90 weight % especially.This diluent also can be same with the said extracted solvent phase; Add diluent, make the gross weight of the compositions of control alopecia of the present invention reach 100 weight portions.
The preparation of compositions method of control alopecia of the present invention comprises, make earlier Chinese medicine extraction liquid according to the method described above, preferably add selectable other additives then again in this Chinese medicine extraction liquid, mix homogeneously is controlled each components contents within the limits prescribed.More than blended order unimportant, can directly mix, also can further mix mutually again with the part component with after diluent mixes mutually, order by merging does not influence the effect of final composition.
If compositions as the control alopecia of solution-type, directly add the additive that needs to above-mentioned active component mixture, such as: wetting agent, spice, pH regulator agent, surfactant, antiseptic, antibacterial, stabilizing agent, diluent etc., control each components contents within the limits prescribed, promptly can make this solution type composition.The compositions advantage of the control alopecia of this solution-type is, is convenient to processing, uses; But setup is poor, easily loss in the use.
As the compositions of the control alopecia of emulsion agent, cream or gel dosage form, can in above-mentioned solution type composition, add thickening agent or other forming agents, such as: compositions such as oiliness composition, emulsifying agent and/or thickening agent are prepared according to existing method.For example stearic acid, stearyl alcohol or lanoline etc. of oiliness composition wherein; Emulsifying agent, for example: octyldodecanol or polyoxy second cetyl ether etc.The advantage of the compositions of such control alopecia is because of having better stop effect, can solving the waste that the drain mistake produces in the medicinal liquid use.The while unguentum, the slow releasing function of gel also helps the further absorption of medicinal liquid.Therefore the compositions of the control alopecia of this dosage form is particularly preferred.
For the compositions of the control alopecia of patch, wet tissue type, can utilize above-mentioned active component mixture by conventional method preparation, advantage is that volume is little, is easy to carry, and is easy to use.
According to another embodiment of the present invention, the compositions that a kind of described control alopecia is provided preparation be used for controlling alopecia medicine or the application of articles for daily use.
Medicine wherein, for example be used to control alopecia washing liquid, emulsion, spray, dew liquid, unguentum, gel, cream, Emulsion, patch, wet tissue etc.Articles for daily use wherein, for example: shampoo, hair conditioner, hair care breast, send out film etc.
According to the compositions of control alopecia of the present invention, usage and consumption are got according to the alopecia situation and preferably are applied to alopecia place scalp in right amount, massage gently to promote absorbing twice of every day.
Below by specific embodiment technical scheme of the present invention and effect thereof are further specified.
Embodiment
Embodiment 1
Take by weighing the raw material of Chinese medicine of weight weight as shown in table 2, they are immersed accordingly extract in the ethanol water as the 50 weight % that extract solvent, stirred once in every 10-12 hour, soak time is 2 days; Filter, left standstill 24 hours, get supernatant liquid filtering, filter liquor is the extracting solution of the Chinese medicine that obtains, and adds the ethanol water of 50 weight % in the extracting solution of this Chinese medicine, makes the weight of solution reach 6000g, makes the compositions of solution-type control alopecia.
Embodiment 2
Other conditions are identical with the method for embodiment 1, and just the amount of each raw material of Chinese medicine and extraction solvent is as shown in table 2, make the compositions of another kind of solution-type control alopecia.
Embodiment 3
Take by weighing weight raw material of Chinese medicine as shown in table 2, half of ethanol water that their are immersed 75 weight % shown in table 2 be as extracting solvent, extracted 2 hours in 78-80 ℃, filters.The filtering residue that obtains is used in the ethanol water of second half 75 weight % once more, extracts filtration 1.5 hours in 78-80 ℃.Merge the filter liquor that twice filtration obtains, left standstill 24 hours, get supernatant liquid filtering, filter liquor is the extracting solution of the Chinese medicine that obtains, in the extracting solution of this Chinese medicine, add the ethanol water of 75 weight %, make the weight of solution reach 6000g, make the compositions of solution-type control alopecia.
The amount of the compositions needed raw material of the control alopecia of table 2 embodiment 1-3
Effect example 1:
The compositions of above embodiment 1 prepared control alopecia is carried out the effect experiment, use hair loss patient totally 50 examples, each 25 people of men and women test it and used this product 1 month, and 2 months, 3 months, alopecia in early morning quantity.
Alopecia quantity with early morning with 30 ℃ of warm water washing hairs 10 minutes, use filtered through gauze, calculate alopecia quantity.
Data from top form can see clearly that the compositions of this control alopecia can effectively be controlled alopecia at short notice, and effective percentage reaches 96%.In three months, alopecia quantity decreased average is about 44.1%, and effect is very obvious.
Effect example 2
The compositions of above embodiment 2 prepared control alopecias is carried out the effect experiment, use hair loss patient totally 50 examples, test it and used this product 1 month, 2 months, 3 months, alopecia in early morning quantity.
Alopecia quantity with early morning with 30 ℃ of warm water washing hairs 10 minutes, use filtered through gauze, calculate alopecia quantity.
Data from top form can see clearly that the compositions of this control alopecia can effectively be controlled alopecia at short notice, and effective percentage reaches 98%.In three months, alopecia quantity decreased average is about 44.9%, and effect is very obvious.
Effect example 3
The compositions of above embodiment 3 prepared control alopecias is carried out the effect experiment, use hair loss patient totally 50 examples, test it and used this product 1 month, 2 months, 3 months, alopecia in early morning quantity.
Alopecia quantity with early morning with 30 ℃ of warm water washing hairs 10 minutes, use filtered through gauze, calculate alopecia quantity.
Data from top form can see clearly that the compositions of this control alopecia can effectively be controlled alopecia at short notice, and effective percentage reaches 98%.In three months, alopecia quantity decreased average is about 43.3%, and effect is very obvious.
In addition, investigate for the experimenter in the above effect example 1,2,3,100% experimenter feels that daily alopecia amount reduces in the compositions process of using the control alopecia.
Those skilled in the art can carry out about various improvement of the present invention and variation under the guidance of above instruction.Therefore, be understandable that, under the situation of the invention thinking that does not break away from claim of the present invention, can implement the present invention in other modes except the specifically described mode of this paper.
Claims (11)
1. compositions of controlling alopecia, its raw material comprises Chinese medicine ingredients, described Chinese medicine ingredients is grouped into by following one-tenth:
Radix Angelicae Sinensis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Sophorae Flavescentis, Cortex Lycii, Rhizoma Zingiberis, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Fructus Chaenomelis, Rhizoma Chuanxiong, Semen Cuscutae, Rhizoma Gastrodiae, Radix Ginseng, Herba speranskiae tuberculatae, the Radix Paeoniae Alba and Caulis Spatholobi;
Be somebody's turn to do the compositions of controlling alopecia with respect to 100 weight portions, the weight portion of described every kind of Chinese medicine ingredients all drops within the 0.2-2 weight portion;
The compositions of described control alopecia comprises the Chinese medicine extraction liquid of described Chinese medicine ingredients, wherein, described Chinese medicine extraction liquid is with extracting that solvent extracts described Chinese medicine ingredients and the Chinese medicine extraction liquid that obtains, and described extraction solvent is water and/or the alcohols that meets the medicine regulation.
2. the compositions of control alopecia according to claim 1 wherein, adopts cold extraction and/or boils the mode of putting forward, and with extracting solvent described raw material is extracted, and obtains this Chinese medicine extraction liquid.
3. the compositions of control alopecia according to claim 2, wherein, use and to boil the method for putting forward and extract: boil at twice with the ethanol water of 50-75 weight % and carry described raw material, boil the time of carrying is 1-3 hour at every turn, and temperature is 70-90 ℃.
4. the compositions of control alopecia according to claim 1 and 2, wherein, further contain additive, this additive is selected from one or more in diluent, wetting agent, wetting agent, solubilizing agent, thickening agent, spice, dyestuff, pH regulator agent, surfactant, antiseptic, antibacterial, stabilizing agent, emulsifying agent, buffer agent and the excipient.
5. the compositions of control alopecia according to claim 1 and 2, wherein, the compositions of described control alopecia is solution or semi-solid form.
6. the compositions of control alopecia according to claim 1 and 2, wherein, the compositions of described control alopecia is washing liquid, spray or reveals liquid.
7. the compositions of control alopecia according to claim 1 and 2, wherein, the compositions of described control alopecia is unguentum, gel, cream, Emulsion, patch or wet tissue.
8. the preparation of compositions method of the described control alopecia of each claim of claim 1～7 wherein, may further comprise the steps:
With extracting solvent described raw material is extracted, obtain Chinese medicine extraction liquid; Described extraction solvent is water and/or the alcohols that meets the medicine regulation.
9. preparation method according to claim 8 wherein, is extracted the employing cold extraction and/or is boiled the mode of putting forward described raw material with extracting solvent.
10. preparation method according to claim 9, wherein, use and to boil the method for putting forward and extract: boil at twice with the ethanol water of 50-75 weight % and carry described raw material, boil the time of carrying is 1-3 hour at every turn, and temperature is 70-90 ℃.
11. the compositions of the described control alopecia of each claim of claim 1～7 is used for controlling the medicine of alopecia or the application of articles for daily use in preparation.
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|---|---|---|---|---|
| CN102038626B (en) * | 2010-11-29 | 2012-01-18 | 霸王（广州）有限公司 | Traditional Chinese medicinal hair-restoring and anti-alopecia shampoo and preparation method thereof |
| CN102579735B (en) * | 2012-02-24 | 2013-10-23 | 北京章光101科技股份有限公司 | Male scalp-refreshing hair-nurturing lotion and preparation method thereof |
| CN102885742B (en) * | 2012-11-06 | 2014-03-12 | 蒋亚飞 | Fleece flower root wet wipe for wiping hair and scalp and preparation method of fleece flower root wet wipe |
| CN103830716B (en) * | 2014-03-25 | 2017-04-05 | 苏志云 | It is a kind of with refreshing the mind, removing blood stasis for promoting tissue regeneration, hair tonic protect the Chinese medicine preparation of brain effect |
| CN104958343A (en) * | 2015-07-29 | 2015-10-07 | 史克勇 | Medicine for treating alopecia areata |
| CN104958344A (en) * | 2015-07-31 | 2015-10-07 | 史克勇 | Medicine for treating alopecia areata |
| CN110200887A (en) * | 2019-07-01 | 2019-09-06 | 安徽大学 | A kind of multiple-effect hair growing gel and preparation method thereof |
Citations (1)
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| CN1500515A (en) * | 2002-11-19 | 2004-06-02 | 赵传水 | Formula of Chinese caterpillar fungus extract for stabilizing, regenerating and blackening hair, and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1500515A (en) * | 2002-11-19 | 2004-06-02 | 赵传水 | Formula of Chinese caterpillar fungus extract for stabilizing, regenerating and blackening hair, and its preparation method |
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| 刘悦坡.近五年中医药内服法辨证论治脱发概况.《光明中医》.2005,第20卷(第1期),29-31. * |
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