CN110200887A - A kind of multiple-effect hair growing gel and preparation method thereof - Google Patents
A kind of multiple-effect hair growing gel and preparation method thereof Download PDFInfo
- Publication number
- CN110200887A CN110200887A CN201910583198.3A CN201910583198A CN110200887A CN 110200887 A CN110200887 A CN 110200887A CN 201910583198 A CN201910583198 A CN 201910583198A CN 110200887 A CN110200887 A CN 110200887A
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- Prior art keywords
- hair
- water
- phase
- added
- hair growing
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Abstract
The invention discloses a kind of multiple-effect hair growing gels and preparation method thereof.Product of the present invention, which is chosen, has the characteristics that ingredient is simple, skin sense is salubrious, the aqueous gel without grease is carrier, with Fructus Forsythiae, cacumen biotae, radix scutellariae, the fruit of glossy privet, dandelion, 50% alcohol extract of Radix Glycyrrhizae for main hair tonic ingredient, addition ginger, red ginseng, Carbonado Diamond liquid nourish hair root, nutrition hair to promote head blood circulation.Product of the present invention has stronger antibacterial, anti-inflammatory, the anti-oxidant and inhibition active effect of 5α-reductase, can mitigate sebum secretion, enhance hair follicle metabolism function, promote hair regeneration；More there are good anti-avulsion, hair care, strengthen the hair, hair care effect, effectively slow down the symptom of alopecia, mitigates the worry of hair loss patient.
Description
Technical field
The invention belongs to daily chemical product technical fields more particularly to a kind of multiple-effect hair growing gel and preparation method thereof.
Background technique
Pathologic alopecia refers to that hair is abnormal or excessive and falls off that there are many reason.Current main alopecia type has scar
Trace alopecia, alopecia areata, androgenetic alopecia.Wherein most commonly seen alopecia type is androgenic alopecia also known as seborrheica
Alopecia.Alopecia seborrheica is mainly caused by androgen and its receptor abnormality, also related with heredity and the factors such as psychology.
So-called product for improving hair-growing, be by added in Shampoo & Conditioner it is some have effects that the active constituent of hair tonic and reach
Hair regrowth, addition updates with the development of science and technology and constantly at branch.Strictly speaking, qualified product for improving hair-growing
There should be good hair-growing effects, more to guarantee its safety used, obvious stimulation and damage cannot be generated to skin.
Main adding ingredient includes: currently on the market
Add synthesis of chemicals: current research suggests that minoxidil can directly hair follicle stimulating epithelial cell proliferation and point
Change, makes hair follicle from the conversion of stand-down to growth period, to achieve the effect that hair tonic.However, this is the guess of people, minot
You are found that hair tonic mechanism is still unknown so far in one experiment.In addition, using meeting early period of minoxidil
Have it is mad fail to come out on time, accelerate originally to accelerate into catagen in the hair of stand-down, hair tonic could be stablized by taking around one-year age,
And there is dependence, possible alopecia is more serious after drug withdrawal, and price is relatively high.Minoxidil is for promoting hair growth
Really there is certain effect, but long-time service can generate dependence, while also cause the adverse reaction of human body, once deactivating will
There is more serious skin problem.
Addition hormone inhibitors: if Finasteride can inhibit the secretion of androgen indirectly, principle is that testosterone is inhibited to turn
It is melted into dihydrotestosterone (DHT), so that effectively reducing blood and intraprostatic dihydrotestosterone (DHT) influences to inhibit de-
Hair, so treatment male sex hormone source property alopecia is relatively good.Finasteride inhibits male and swashs primarily as 5α-reductase inhibitor
The generation of element achievees the effect that alleviate alopecia, but its side effect has sexual hypoesthesia and has an impact to fertility.
Add highly-safe active matter: selecting ingredient that is highly-safe and having certain hair tonic effect, from invigorate blood circulation, promote the production of body fluid,
The key links such as tonifying Qi are started with, including generally acknowledged hair tonic active constituent ginger, Rhizoma Chuanxiong, glossy privet, tuber of multiflower knotweed etc., due to producing to hair tonic
The stability of product has certain requirement that the additive amount of each active constituent in the product is made to have certain limitation.
It is obtained with the development of science and technology, many producers pass through the methods of wrap up improvement, derivative synthesis, improve extraction process
Safety, the higher active matter of activity, make it can also be to the performance of product efficacy while with certain hair-growing effects
Certain promotion is played, but is that cost is constantly increasing thereupon.
Largely scientific investigations showed that, the androgen of human secretory is mainly testosterone, and testosterone is under the action of 5α-reductase
It is changed into protona, then in conjunction with the androgen receptor in scalp portion hair follicle target cell, inhibits the growth and development of papilla, does
The growth metabolism for disturbing hair follicle cell, makes hair enter stand-down in advance, so as to cause androgenetic alopecia.Androgen is to influence
An important factor for hair follicle development, and have substantial connection with alopecia seborrheica, therefore it is very crucial to find 5α-reductase inhibitor.It removes
Except this, spirit aspect, anxiety, melancholy, fear etc. are responsible for nerve dysfunction, and capillary is continuously in contraction-like
State, hair follicle cannot get corresponding blood supply, it is also possible to lead to falling off for hair；In terms of diet, animal based food is human body conjunction
Condition is provided at excessive male sex hormone, and 3male hormone secretion is excessive, and the smegma of people can be promoted vigorous, at this time just
A kind of lipophagia fungi present on the scalp of ordinary person will mass propagation, which is obtaining nutrition and discharge metabolite mistake
Cheng Zhongke stimulates scalp and hair follicle, forms chronic inflammation, makes hair follicle gradually atrophy, systematic function gradually fails.
For product for improving hair-growing, leading to its unconspicuous reason of hair tonic effect may be the mechanism not generated from alopecia
It is studied.Therefore the product for improving hair-growing of a new generation needs to have certain research to the mechanism of alopecia and proposes countermeasure, such ability
Enough reach preferable hair tonic effect.After the analysis for having carried out system to the mechanism of alopecia, discovery adapts to customer demand
Product for improving hair-growing should be on the basis of guaranteeing harmless to skin safe, and to have simultaneously reduces internal Serum Testosterone Levels, rush
The effects of aoxidizing into blood circulation, inhibition papilla Epithelial cell apoptosis, inhibition sebum, inhibit inflammatory reaction, is antibacterial.
Summary of the invention
The object of the present invention is to provide a kind of multiple-effect hair growing gels and preparation method thereof, are reducing body to the Chinese herbal medicine extract
Interior Serum Testosterone Levels promote blood circulation, inhibit papilla Epithelial cell apoptosis, inhibit sebum oxidation, inhibit inflammation
On the basis of the abilities such as reaction, antibacterial carry out more comprehensive comparative studies, selection is simple with ingredient, skin sense is salubrious, is free of
The gel of the features such as grease is as carrier, with cacumen biotae, radix scutellariae, the fruit of glossy privet, dandelion, Radix Glycyrrhizae for main hair tonic ingredient, compounding
To enhance the inhibitory effect to 5α-reductase, addition ginger, red ginseng, Radix Notoginseng, Carbonado Diamond object are used to promote head blood Fructus Forsythiae
Liquid circulation, nourishes hair root, nutrition hair, develops the product for improving hair-growing with multi-efficiency.The product has stronger antibacterial, anti-
Scorching, antioxidation, can mitigate sebum secretion, can promote hair regeneration, alopecia symptom is effectively relieved, and mitigate the tired of hair loss patient
It is angry, achieve the purpose that safe hair tonic.
In order to achieve the above purpose, the present invention the following technical schemes are provided:
A kind of multiple-effect hair growing gel, including A phase, B phase, C phase and D phase；
The A phase includes the raw material of following weight ratio: Acritamer 940 0.4-0.6g, glycerol 4-6g, butanediol 1.5-
2.5g, disodium ethylene diamine tetraacetate 0.04-0.06g, triethanolamine 0.4-0.6g, water 25-30g；
The B phase includes the raw material of following weight ratio: compounding the Chinese herbal medicine extract 47-53g, ginger extract 8-12g；
The C phase includes the raw material of following weight ratio: water/butanol/ginseng root extract liquor 0.9-1.1g can extract
Object & water 0.4-0.6g；
The D phase includes the raw material of following weight ratio: PCG (mixture of 1,2- ethohexadiol and 2- phenoxetol)
0.8-1.2g；
Water adds to 100g.
Preferably, the A phase includes the raw material of following weight ratio: Acritamer 940 0.5g, glycerol 5g, butanediol 2g,
Disodium ethylene diamine tetraacetate 0.05g, triethanolamine 0.5g, water 28g；
Preferably, the B phase includes the raw material of following weight ratio: compounding the Chinese herbal medicine extract 50g, ginger extract
10g；
Preferably, the C phase includes the raw material of following weight ratio: water/butanol/ginseng root extract liquor 1g, cocoa mention
Take object & water 0.5g；
Preferably, the D phase includes the raw material of following weight ratio: PCG (1,2- ethohexadiol and 2- phenoxetol it is mixed
Close object) 1g；
Water adds to 100g.
It is described compounding the Chinese herbal medicine extract include Fructus Forsythiae, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae, Radix Glycyrrhizae extracting solution.
It is described compounding the Chinese herbal medicine extract the preparation method comprises the following steps: each Chinese herbal medicine is placed in Constant Temp. Oven, in 45
It for 24 hours, is crushed respectively with pulverizer, accurately weighs each 3g of Fructus Forsythiae, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae are each by drying at DEG C
2g, Radix Glycyrrhizae 0.8g are packed into filter bag and are placed in 250mL round-bottomed flask, 50% ethanol water of 50mL is added, add in boiling water bath
Heat reflux 1h, adds appropriate extractant, makes extracting solution total amount 47-53g, obtain compounding the Chinese herbal medicine extract after reflux.
The ginger extract the preparation method comprises the following steps: precise ginger 4g, cleans, is cut into powder, be placed in a beaker, add
Enter a small amount of distilled water, seals rim of a cup with preservative film, in 75 DEG C of water-baths after heating extraction 1h, appropriate distilled water is added in filtering,
Make extracting solution gross mass 8-12g, obtains ginger extract.
A kind of preparation method of above-mentioned multiple-effect hair growing gel, comprising the following steps:
(1) the A phase added in addition to triethanolamine after the Acritamer 940 in A phase being uniformly dispersed in advance in water is other
Raw material is subsequently placed in 70-75 DEG C of water-bath and stirs 25-30min, dissolves decorating film, obtains mixture A；
(2) B is added in mixture A, quickly stirs 5-10min at 70-75 DEG C, then begin to cooling of slowing down,
Triethanolamine and C phase and D phase are added when to 40-45 DEG C, stirs evenly, stops stirring when continuing to be cooled to 30-35 DEG C, discharging,
Up to hair growing gel of the present invention.
Distilled water is added in temperature-fall period in the step (2) so that finished product gross mass is 100g.
The invention has the advantages that
The aqueous gel that the present invention has selected skin sense salubrious is matrix, with Fructus Forsythiae, cacumen biotae, radix scutellariae, the fruit of glossy privet, Pu Gong
English, 50% ethanol extract of Radix Glycyrrhizae are main composition.Wherein, Fructus Forsythiae, radix scutellariae, Radix Glycyrrhizae have preferable inhibition 5 α-reduction
The effect of enzyme；Dandelion has preferable anti-inflammatory effect；Fructus Forsythiae, radix scutellariae, dandelion have anti-oxidant and bacteriostasis simultaneously；Side
CedarLeaves can promote local blood circulation, enhance hair follicle metabolism function, remove dandruff, promote hair regeneration；The fruit of glossy privet is for pressing down
Papilla Epithelial cell apoptosis processed；Ginger, red ginseng, Carbonado Diamond object etc. promote head blood circulation, nutrition hair.
Hair growing gel quality of the invention is salubrious, skin sense is preferable；Grease, essence are not added；Also with stronger inhibition 5 α-
Protoenzyme, anti-inflammatory, anti-oxidant, bacteriostasis can mitigate sebum secretion, enhance hair follicle metabolism function, promote hair regeneration；More have good
Anti-avulsion well, hair care, strengthen the hair, hair care effect, effectively slow down the symptom of alopecia, mitigate the worry of hair loss patient；Product system simultaneously
Preparation Method is simple, is easy to large-scale production, wide market.
Detailed description of the invention
Fig. 1 show hair growing gel of the present invention after 52 years old male trier was using preceding and continuous use four months
Hair growth situation, wherein before (a) use；(b) after being used continuously four months.
Fig. 2 show hair growing gel of the present invention after 50 years old male trier was using preceding and continuous use four months
Hair growth situation, wherein before (a) use；(b) after being used continuously four months.
Specific embodiment
Below in conjunction with specific example, technical scheme is described further:
Raw material explanation:
Acritamer 940 is purchased from Lubrizol Corp., the U.S.；
Disodium ethylene diamine tetraacetate analyzes pure, Sinopharm Chemical Reagent Co., Ltd.；
Triethanolamine analyzes pure, Sinopharm Chemical Reagent Co., Ltd.；
PCG (mixture of 1,2- ethohexadiol and 2- phenoxetol), Nanjing Si Baike biochemistry Industrial Co., Ltd.；
Fructus Forsythiae, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae, Radix Glycyrrhizae are purchased from the Hefei City big pharmacy of common people's edge；
Water/butanol/ginseng root extract liquor, cocoa extract water, is purchased from Guangzhou Lai Yu Biotechnology Co., Ltd.
A kind of multiple-effect hair growing gel, including A phase, B phase, C phase and D phase；
The A phase includes the raw material of following weight ratio: Acritamer 940 0.5g, glycerol 5g, butanediol 2g, ethylenediamine tetraacetic
Acetic acid disodium 0.05g, triethanolamine 0.5g, water 28g；
The B phase includes the raw material of following weight ratio: compounding the Chinese herbal medicine extract 50g, ginger extract 10g；
The C phase includes the raw material of following weight ratio: water/butanol/ginseng root extract liquor 1g, cocoa extract water
0.5g；
The D phase includes the raw material of following weight ratio: PCG (mixture of 1,2- ethohexadiol and 2- phenoxetol)
1g；
Add water to 100g.
It is described compounding the Chinese herbal medicine extract include Fructus Forsythiae, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae, Radix Glycyrrhizae extracting solution.
It is described compounding the Chinese herbal medicine extract the preparation method comprises the following steps: each Chinese herbal medicine is placed in Constant Temp. Oven, in 45
It for 24 hours, is crushed respectively with pulverizer, accurately weighs each 3g of Fructus Forsythiae, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae are each by drying at DEG C
2g, Radix Glycyrrhizae 0.8g are packed into filter bag and are placed in 250mL round-bottomed flask, 50% ethanol water of 50mL is added, add in boiling water bath
Heat reflux 1h, adds appropriate extractant, makes extracting solution total amount 50g, obtain compounding the Chinese herbal medicine extract after reflux.
The ginger extract the preparation method comprises the following steps: precise ginger 4g, cleans, is cut into powder, be placed in a beaker, add
Enter a small amount of distilled water, seals rim of a cup with preservative film, in 75 DEG C of water-baths after heating extraction 1h, appropriate distilled water is added in filtering,
Make extracting solution gross mass 10g, obtains ginger extract.
The preparation method of above-mentioned multiple-effect hair growing gel, comprising the following steps:
(1) the A phase added in addition to triethanolamine after the Acritamer 940 in A phase being uniformly dispersed in advance in water is other
Raw material is subsequently placed in 70-75 DEG C of water-bath and stirs 25-30min, dissolves decorating film, obtains mixture A；
(2) B is added in mixture A, quickly stirs 5-10min at 70-75 DEG C, then begin to cooling of slowing down,
Triethanolamine and C phase and D phase are added when to 40-45 DEG C, stirs evenly, stops stirring when continuing to be cooled to 30-35 DEG C, discharging,
Up to hair growing gel of the present invention.
Distilled water is added in temperature-fall period in the step (2) so that finished product gross mass is 100g.
The performance test of gained hair growing gel:
Dandelion, radix scutellariae, Fructus Forsythiae, Radix Glycyrrhizae are respectively placed in round-bottomed flask with 50% ethyl alcohol heating and refluxing extraction 1h, will mention
It takes liquid to be settled to scale with solvent, obtains active compound content and be each the Chinese herbal medicine extract of 100g/L, then be diluted to active compound content and be
10g/L。
Gel products 1g obtained is weighed, is settled to after using water to dissolve in small beaker in 10mL volumetric flask as to be measured
Liquid, the measurement for DPPH free radical scavenging activity and hyaluronic acid enzyme inhibition rate；Product is not required to dilute when measuring testosterone conversion ratio
It releases.
1, the measurement of DPPH free radical scavenging activity
Prepare liquid is taken respectively and substance withdrawl syndrome is 2.00 × 10-4Each 3mL of the DPPH ethanol solution of mol/L is added same
It in one tool plug test tube, shakes up, after avoid light place 30min, with ultraviolet-visible spectrophotometer measurement mixed solution at 517nm
Absorbance Ai, while pure water and the 3mL concentration for measuring 3mL are 2.00 × 10-4The DPPH ethanol solution of mol/L is mixed
Absorbance A0With 3mL testing sample solution and the mixed absorbance A of 3mL dehydrated alcoholj, clearance rate P is calculated according to formula (1):
P=[1- (Ai- Aj)/A0] × 100% (1)
2, the measurement of hyaluronic acid enzyme inhibition rate
(1) configuration of solution
The preparation of hac buffer: the vinegar of 113mL 0.2mol/L sodium acetate solution and 12mL 0.2mol/L is taken respectively
Acid solution adjusts pH to 5.6 into 250mL volumetric flask, and with distilled water constant volume.
The preparation of 0.5g/L sodium hyaluronate solution: being accurately weighed Sodium Hyaluronate 50mg, dissolved with hac buffer,
It is settled in 100mL volumetric flask.
The preparation of the hyaluronidase solution of 1g/L: being accurately weighed hyaluronidase 50mg, dissolved with hac buffer,
It is settled in 50mL volumetric flask.
The preparation of Ehrlich's reagent: accurately weighing paradime thylaminobenzaldehyde 0.8g, be separately added into 15mL dehydrated alcohol,
The dense HCL dissolution of 15mL, obtains Ehrlich's reagent.
Water as solvent is only used in the preparation of remaining solution.
(2) experimental implementation
Take the CaCl of 0.25mmol/L2Solution 0.2mL and 1g/L hyaluronidase solution 1mL, 37 DEG C of heat insulating cultures
20min；Prepare liquid 1mL, 37 DEG C of heat insulating culture 20min is added；0.5g/L sodium hyaluronate solution 1mL, 37 DEG C of heat preservations are added
40min；0.4mol/L sodium hydroxide solution 0.2mL, ice-water bath 8min is added；1g/L boric acid solution 0.2mL, boiling water bath 10 is added
Ice-water bath 8min terminates reaction immediately after minute, Ehrlich's reagent 4.0mL is added, 5min colour developing is placed in 37 DEG C of heat preservations, to go
Ionized water measures absorbance at 585nm as reference, ultraviolet-visible spectrophotometer.Hyaluronidase is calculated by formula (2)
Inhibiting rate I:
× 100% (2) I=[1- (C-D)/(A-B)]
In formula: A is by contrast solution absorbance value (replacing sample solution with solvent)；B is placebo solution absorbance value
(replacing sample solution with solvent, the hac buffer of pH=5.6 replaces hyaluronidase solution)；C is prepare liquid absorbance
Value；D is by sample controls solution absorbance value (hac buffer of pH=5.6 replaces hyaluronidase solution).
3, the measurement of testosterone conversion ratio
(1) extraction of 5α-reductase and assay
4 male SD rats are deprived of food but not water for 24 hours, and the neck that breaks is put to death, and are taken out liver weighing rapidly, are shredded on ice platform.It presses
The 0.1mol/L Tris buffer of pre-cooling is added in 1: 5 ratio, sufficiently shakes up, with 8000r/min at 4 DEG C low-temperature centrifugation
30min.Its supernatant i.e. 5α-reductase extracting solution is taken to save in refrigerator freezing.It is with bovine serum albumin(BSA) concentration of standard solution
Absorbance is y at x, 595nm wavelength, draws standard curve, obtains regression line equation y=44.39x+0.682 (R=0.988).By 5
The absorbance that measures substitutes into regression equation after 5 alpha-reductases extracting solution dilutes 10 times, calculates to obtain 5α-reductase in former extracting solution
Concentration is 0.29g/L.
(2) chromatographic condition
Chromatographic column: Waters SunFireTMC18 column (4.6mm × 250mm, 5 μm), mobile phase: methanol-water (70:30, v/
V), double pump；Detection wavelength: 242nm；Flow velocity: 1.0mL/min, sample volume 20.00 μ L, 30 DEG C of column temperature.
(3) preparation of reactant solution and positive control drug series of concentrations
The testosterone solution that 1.0g/L is prepared using methanol as solvent is prepared by solvent of 0.1mol/L Tris buffer
The NADPH solution of 4.25g/L.
The preparation of positive control drug series of concentrations: it takes 10 epristeride pieces to be put into mortar, is fully ground to powder
It pours into beaker.Add proper amount of methanol (50%) sufficiently dissolve, be transferred in 25mL volumetric flask, constant volume, shake up concentration be 2.0g/L
The positive control solution of concentration.
(4) preparation of testosterone standard curve
20,40,60,80, the 100 μ L of testosterone solution of 1.0g/L is accurately pipetted in the volumetric flask of 5mL, extremely with methanol constant volume
Scale shakes up set aside for use.By above-mentioned chromatographic condition sample introduction, retention time t=10.3min.It is x, peak area with testosterone concentration
For y, draw standard curve, calculate its calibration curve equation is y=7.50 × 104X-88.5 (R=0.999).
The foundation of reaction system
Testosterone solution, NADPH solution, 5α-reductase extracting solution, epristeride solution, Tris buffer, Chinese herbal medicine are mentioned
It takes liquid to sequentially add reaction system by combination in table 1, is set to positive controls, blank control group, reaction group, is put into temperature
After reacting 1h in 37 DEG C of constant incubators, reaction solution is taken out, the methanol of 2mL is added, terminates reaction.
1 vitro reactions system of table
The measurement of testosterone conversion ratio
Above-mentioned reaction system is sufficiently shaken up, 2min is centrifuged with 4000r/min at room temperature；Supernatant is taken, is had with micropore
Sample introduction after machine filter film (0.45um) filtering, the peak area of the testosterone measured is substituted into its calibration curve equation, calculates unreacted
Testosterone content xi, further according to the original amount x of testosterone0Calculate testosterone conversion ratio T.
T=(1-xi/x0) × 100%
4, the stability test of hair growing gel
Under direct sunlight, color, glossiness, uniformity, form of hair growing gel etc. are observed, while touching sample with hand
Consistency, viscosity, thixotropy；Respectively at 45 DEG C, whether observation sample becomes after taking out after placing one day under the conditions of -10 DEG C
Change.
5, the investigation on probation of hair growing gel.
The Chinese herbal medicine extract and final products test result:
Several Chinese herbal medicines are shown in Table 2 to the test result of DPPH free radical and hyaluronic acid enzyme inhibition rate
Test result of several Chinese herbal medicines of table 2 to DPPH free radical and hyaluronic acid enzyme inhibition rate
It can be seen that in table 2, Fructus Forsythiae, radix scutellariae, dandelion all 90% or more, have preferable anti-the clearance rate of DPPH
Oxidation；Dandelion reaches 92.6% to hyaluronic acid enzyme inhibition rate, has preferable anti-inflammatory effect, Fructus Forsythiae, radix scutellariae, Radix Glycyrrhizae
Inhibiting rate also 60% or more, also have certain anti-inflammatory effect.
Influence of several the Chinese herbal medicine extracts to testosterone conversion ratio is listed in table 3.
Conversion ratio of several the Chinese herbal medicine extracts of table 3 to testosterone
| The Chinese herbal medicine extract 100g/L | Testosterone conversion ratio T/% |
| Blank | 59.7 |
| Fructus Forsythiae | 24.8 |
| Radix Glycyrrhizae | 27.2 |
| Radix scutellariae | 28.5 |
| Dandelion | 41.2 |
| Epristeride solution (2.0g/L) | 28.8 |
Influence of several the Chinese herbal medicine extracts to testosterone conversion ratio is shown in Table 3.It is mentioned in table as it can be seen that Fructus Forsythiae, radix scutellariae, Radix Glycyrrhizae is added
Liquid is taken, testosterone conversion ratio is respectively 24.8%, 27.2% and 28.5%, respectively less than epristeride corresponding conversion in 2.0g/L
Rate 28.8%；Dandelion extracting solution is added, testosterone conversion ratio 41.2%, the conversion ratio of testosterone is then high when the Chinese herbal medicine extract is not added
Up to 59.7%.It can be seen that several the Chinese herbal medicine extracts can make the reduction of testosterone conversion ratio, i.e., there is certain inhibition to 5α-reductase
Effect, wherein inhibitory effect most preferably Fructus Forsythiae.
The stability test result of hair growing gel such as table 4.
4 product sensory of table and physical and chemical index
The effect of product of the present invention, test result is as follows: the inhibiting rate to DPPH free radical is 88.8%, to hyaluronic acid
Enzyme inhibition rate is 56.4%, and testosterone conversion ratio is 45.0% after being directly added into product.
In summary analysis it can be found that hair growing gel performance of the invention is stablized, have it is significant anti-oxidant, anti-inflammatory and
Bacteriostasis can preferably inhibit the activity of 5α-reductase, reduce testosterone conversion ratio.
The feedback on probation of hair growing gel.Product of the present invention collects more than 20 people of volunteer, secondary daily to be applied to alopecia position, makes
With the several months, collects feedback opinion and take pictures.Most volunteers think that the product has certain hair regrowth, and hair can be made to become
Slightly, sparse hair is enabled to become dense；And strengthen the hair effect is very good, can prevent further large area alopecia.
Claims (6)
1. a kind of multiple-effect hair growing gel, which is characterized in that including A phase, B phase, C phase and D phase；
The A phase includes the raw material of following weight ratio: Acritamer 940 0.4-0.6g, glycerol 4-6g, butanediol 1.5-2.5g,
Disodium ethylene diamine tetraacetate 0.04-0.06g, triethanolamine 0.4-0.6g, water 25-30g；
The B phase includes the raw material of following weight ratio: compounding the Chinese herbal medicine extract 47-53g, ginger extract 8-12g；
The C phase includes the raw material of following weight ratio: water/butanol/ginseng root extract liquor 0.9-1.1g, cocoa extract
Water 0.4-0.6g；
The D phase includes the raw material of following weight ratio: the mixture of PCG(1,2- ethohexadiol and 2- phenoxetol) 0.8-
1.2g；
Water adds to 100g.
2. multiple-effect hair growing gel according to claim 1, which is characterized in that the compounding the Chinese herbal medicine extract includes connecting
Stick up, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae, Radix Glycyrrhizae extracting solution.
3. multiple-effect hair growing gel according to claim 2, which is characterized in that the preparation side of the compounding the Chinese herbal medicine extract
Method are as follows: each Chinese herbal medicine is placed in Constant Temp. Oven, drying for 24 hours, is crushed it with pulverizer, accurately respectively at 45 DEG C
Each 3g of Fructus Forsythiae, cacumen biotae, dandelion, the fruit of glossy privet, radix scutellariae each 2g, Radix Glycyrrhizae 0.8g are weighed, filter bag is packed into and is placed in 250mL round bottom burning
Bottle is added 50% ethanol water of 50mL, 1h is heated to reflux in boiling water bath, appropriate extractant is added after reflux, makes to mention
Taking liquid total amount is 47-53g, obtains compounding the Chinese herbal medicine extract.
4. multiple-effect hair growing gel according to claim 1, which is characterized in that the ginger extract the preparation method comprises the following steps:
Precise ginger 4g, cleans, is cut into powder, be placed in a beaker, and a small amount of distilled water is added, and rim of a cup is sealed with preservative film, in 75
In DEG C water-bath after heating extraction 1h, filtering adds appropriate distilled water, makes extracting solution gross mass 8-12g, obtains ginger and extracts
Liquid.
5. a kind of preparation method of multiple-effect hair growing gel as described in claim 1, which comprises the following steps:
(1) the other raw materials of A phase in addition to triethanolamine are added after the Acritamer 940 in A phase being uniformly dispersed in advance in water,
It is subsequently placed in stirring 25-30 min in 70-75 DEG C of water-bath, decorating film is dissolved, obtains mixture A；
(2) B is added in mixture A, 5-10 min is quickly stirred at 70-75 DEG C, then begin to cooling of slowing down, until
Triethanolamine and C phase and D phase are added at 40-45 DEG C, stirs evenly, stops stirring when continuing to be cooled to 30-35 DEG C, discharges, i.e.,
Obtain hair growing gel of the present invention.
6. the preparation method of multiple-effect hair growing gel according to claim 5, which is characterized in that dropped in the step (2)
Distilled water is added during temperature so that finished product gross mass is 100g.
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| US20040161435A1 (en) * | 2003-02-14 | 2004-08-19 | Gupta Shyam K. | Skin Firming Anti-Aging Cosmetic Mask Compositions |
| CN101378729A (en) * | 2005-12-14 | 2009-03-04 | 扎尔斯制药公司 | Compositions and methods for treating dermatological conditions |
| CN101804188A (en) * | 2010-04-14 | 2010-08-18 | 北京章光101科技股份有限公司 | Composition for controlling atrichia and manufacture method thereof |
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