CN104001140A - Paste for treating PICC (Peripherally Inserted Central Catheter) phlebitis and preparation method thereof - Google Patents
Paste for treating PICC (Peripherally Inserted Central Catheter) phlebitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses paste for treating PICC (Peripherally Inserted Central Catheter) phlebitis and a preparation method thereof. The paste is composed of centipede, leech, Herba sarcandrae, pseudo-ginseng, artificial bezoar, Urena lobata, cornu bubali, monascus, honeysuckle, radix paeoniae rubra, Ligusticum wallichii, safflower, phellodendron bark, licorice, saffron, gleditsia sinensis, asarum, ginger, radix curcumae, angelica, radix rehmanniae, mugwort leaf and cassia twig. Liquid medicine is extracted by using a water decoction method; the liquid medicine and honey are used for preparing honey paste. The paste is reasonable in formula, and particularly has obvious treatment effect for phlebitis caused by PICC; the paste is made from pure traditional Chinese medicine and is stable in pharmaceutical effect and free from toxic and side effects and adverse reaction, and PICC is not easy to recur after being treated; and the paste is convenient to apply, low in price, easily received by patients, and has very good clinical application value.
Description
Technical field
The invention belongs to Chinese materia medica technical field, be specifically related to one and treat PICC phlebitis ointment machin its preparation method.
Background technology
PICC (peripherally inserted central catheter) is through the central venous catheter of periphery intubate, is a kind ofly to import and end is positioned at the dark Vein Tube technology of central vein from peripheral vein.Be mainly used in long-term intravenous transfusion, chemotherapy of tumors, parenteral nutrition, elderly patients' transfusion, the patient of NICU is suitable for too.PICC has that puncture is simple, safety, puncture success rate advantages of higher, is applied to more and more widely clinical.But PICC itself operates as a kind of invasive, has some complication.At present, the phlebitis being caused by PICC is one of common complication.
Clinically, the phlebitis causing for PICC, medical personnel adopt soak or some blood circulation promoting and blood stasis dispelling reducing swelling and alleviating pain medicines of external to treat more, but existing in various degree takes effect slowly, cost is high or the defect of injury of primary disorganization blood vessel.
Theory of Chinese medical science thinks that phlebitis belongs to the category of the arthralgia due to stagnation of blood of the traditional Chinese medical science, swelling, blood stasis.Damp and hot outer invading or wound, epidemic disease poison, wound etc., causes QI-blood circulation not smooth, and blood flow is slow, obstruction of collaterals by blood stasis, stagnation of QI and blood may bring about pain; Network road blocks, and blood fortune is obstructed, and water Tianjin is excessive, poly-and be wet, stagnates skin swollen; The strongly fragrant heat-transformation of a specified duration of blood stasis turbid damp, therefore limbs heating; The deficiency of vital energy is difficult to have under one's command venation, and blood stasis knot is poly-, shows shallow channels and appears.In a word, venation dampness blood stasis is the pathogenesis key of primary disease.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides that preparation is convenient, medicine source is wide, cost is low, evident in efficacy, reliable effect, the one that has no side effect treat PICC phlebitis ointment machin its preparation method.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of PICC for the treatment of phlebitis ointment is made up of each raw material components of following weight portion proportioning: 10～20 parts of Scolopendras, 10～20 parts of Hirudos, 20～50 parts of Herba Sarcandraes, 10～50 parts of Radix Notoginseng, 10～30 parts of artificial Calculus Boviss, 20～50 parts of Urena lobata Linn, 10～30 parts of Cornu Bubalis, 10～20 parts, Monas cuspurpureus Went, 30～50 parts of Flos Loniceraes, 30～50 parts of Radix Paeoniae Rubra, 10～20 parts of Rhizoma Chuanxiongs, 30～50 parts, Flos Carthami, 10～20 parts of Cortex Phellodendris, 10～50 parts, Radix Glycyrrhizae, 5～15 parts of Stigma Crocis, 1～10 part of Radix Curcumae, 1～10 part of Radix Angelicae Sinensis, 1～10 part, the Radix Rehmanniae, 1～10 part of Folium Artemisiae Argyi, 1～10 part of Ramulus Cinnamomi, 1～10 part of Fructus Gleditsia, 1～10 part of Herba Asari, 1～10 part, Rhizoma Zingiberis Recens.
Raw material composition and the parts by weight of making described Ointment also can be: 10～20 parts of Scolopendras, 10～20 parts of Hirudos, 20～40 parts of Herba Sarcandraes, 20～50 parts of Radix Notoginseng, 10～30 parts of artificial Calculus Boviss, 20～50 parts of Urena lobata Linn, 10～30 parts of Cornu Bubalis, 10～20 parts, Monas cuspurpureus Went, 30～50 parts of Flos Loniceraes, 30～50 parts of Radix Paeoniae Rubra, 10～20 parts of Rhizoma Chuanxiongs, 40～50 parts, Flos Carthami, 10～15 parts of Cortex Phellodendris, 10～40 parts, Radix Glycyrrhizae, 5～10 parts of Stigma Crocis, 1～5 part of Radix Curcumae, 1～5 part of Radix Angelicae Sinensis, 1～5 part, the Radix Rehmanniae, 1～5 part of Folium Artemisiae Argyi, 1～5 part of 1～5 part of Fructus Gleditsia of Ramulus Cinnamomi, 1～5 part of Herba Asari, 1～5 part, Rhizoma Zingiberis Recens.
Preferred weight part of each component is: 10 parts of Scolopendras, 10 parts of Hirudos, 20 parts of Herba Sarcandraes, 15 parts of Radix Notoginseng, 10 parts of artificial Calculus Boviss, 20 parts of Urena lobata Linn, 30 parts of Cornu Bubalis, 10 parts, Monas cuspurpureus Went, 30 parts of Flos Loniceraes, 30 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Chuanxiongs, 30 parts, Flos Carthami, 10 parts of Cortex Phellodendris, 10 parts, Radix Glycyrrhizae, 5 parts of Stigma Crocis, 1 part of Radix Curcumae, 1 part of Radix Angelicae Sinensis, 10 parts, the Radix Rehmanniae, 8 parts of Folium Artemisiae Argyis, 5 parts of Ramulus Cinnamomi, 1 part of Fructus Gleditsia, 1 part of Herba Asari, 5 parts, Rhizoma Zingiberis Recens.
One is treated PICC phlebitis ointment machin preparation method, comprises following processing step:
(1) by Herba Sarcandrae, Radix Notoginseng, artificial Calculus Bovis, Urena lobata Linn, Cornu Bubali, Monas cuspurpureus Went, Rhizoma Chuanxiong, Flos Carthami, Cortex Phellodendri, Stigma Croci, Radix Angelicae Sinensis, the Radix Rehmanniae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Fructus Gleditsia, Herba Asari, Rhizoma Zingiberis Recens, Hirudo and Scolopendra after washing, sterilizing and dried, carry out pulverization process, porphyrize, cross 100 mesh sieves, then decocting three times, merge three times filtrate, the concentrated extracted extract of getting angry;
(2) Flos Lonicerae, Radix Glycyrrhizae, Radix Curcumae and Radix Paeoniae Rubra drying and crushing are crossed to 100 mesh sieves, become concentrate;
(3) get Mel and be positioned over heating while stirring in container, add paraffin to continue heating, after mix homogeneously, add step (1) extractum, constantly be stirred to mix homogeneously, in the time that temperature is down to 70 DEG C, add step (2) concentrate, mix thoroughly, finally add additive.
Described Mel is the rear Mel of refining.
Described additive is azone, Borneolum Syntheticum, dimethyl sulfoxide, sodium benzoate, Sal.
In the present invention, Scolopendra has the effect of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Hirudo has removing blood stasis stimulates the menstrual flow, effect of Zhu Yu Xiao Disorder; Herba Sarcandrae has heat-clearing and toxic substances removing removing heat from blood, the speckle removing dissipating blood stasis of invigorating blood circulation, expelling wind and removing dampness dredging collateral.Radix Notoginseng has effect of hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Artificial Calculus Bovis have clear away heart-fire, eliminating phlegm, have one's ideas straightened out, the effect of cool liver, endogenous wind stopping, removing toxic substances.Urena lobata Linn has expelling wind and removing dampness, invigorate blood circulation disappear kind, effect of heat reliving and toxin-eliminating; Cornu Bubali has effect of heat clearing away, removing heat from blood, removing toxic substances.Monas cuspurpureus Went have invigorate blood circulation help digestion, effect of water paddy under spleen invigorating warming the stomach, dysentery with red and white feces.Rhizoma Chuanxiong has blood-activating and qi-promoting, effect of wind-expelling pain-stopping.Flos Carthami has invigorating blood circulation, moisturizes, pain relieving, the loose effect of swelling, stimulating the menstrual flow.Cortex Phellodendri has heat clearing and damp drying, effect of eliminating fire and detoxication.Flos Lonicerae has effect of heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind.Rhizoma Chuanxiong has blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, sensible QI and blood, is " the gas medicine in blood ".
Radix Paeoniae Rubra has effect of clots absorbing, pain relieving, removing heat from blood, detumescence.Radix Glycyrrhizae has the effect with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Process use: control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, infantile convulsion; Raw using: control laryngopharynx swelling and pain, peptic ulcer, ulcer sores, solution poison of drug and alimentary toxicosis.Stigma Croci is in extensive range, has the effects such as blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization, looks improving and the skin nourishing, to preventing cardiovascular and cerebrovascular disease, regulating hepatic and renal function texts remarkable.
Radix Curcumae has the only effect of energy, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, depressed liver-energy dispersing and function of gallbladder promoting of invigorating blood circulation, and main breast abdomen coerces that all pains of rib, dysmenorrhes, amenorrhea, lump in the abdomen caking, calentura coma, demented, infantile convulsion, haematemesis, nosebleed are standby, stranguria with blood, sand Stranguria and jaundice.Radix Angelicae Sinensis have enrich blood invigorate blood circulation, effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down and ulcer sores.
Effect that the Radix Rehmanniae has clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid, for calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, spit blood, epistaxis and send out speckle dermexanthesis.Folium Artemisiae Argyi has effect of warming the meridian for stopping bleeding, dispersing cold for relieving pain, wet down parasite killing.Ramulus Cinnamomi has effect of diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Fructus Gleditsia have search wind, draw out pus by applying a plaster to the affected part, effect of detumescence, evacuation of pus.Herba Asari has effect of expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention, breathes with cough etc. for anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention.Rhizoma Zingiberis Recens has to be delivered, cold expelling, preventing or arresting vomiting, opens effect of expectorant, cures mainly cold, vomiting, phlegm retention, breathes with cough, distension, has loose bowels etc.
The present invention compared with prior art, has following beneficial effect: Ointment in Treatment effect of the present invention is remarkable, especially for there being the phlebitis that PICC causes to have significant curative effect; Salve application of the present invention is convenient, low price, and patient is easy to accept, and has good clinical value; Ointment of the present invention adopts pure Chinese medicinal preparation, and efficacy stability, has no side effect and untoward reaction, is difficult for more afterwards recurrence.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the parts by weight of Ointment of the present invention are: 10 parts of Scolopendras, 10 parts of Hirudos, 20 parts of Herba Sarcandraes, 15 parts of Radix Notoginseng, 10 parts of artificial Calculus Boviss, 20 parts of Urena lobata Linn, 30 parts of Cornu Bubalis, 10 parts, Monas cuspurpureus Went, 30 parts of Flos Loniceraes, 30 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Chuanxiongs, 30 parts, Flos Carthami, 10 parts of Cortex Phellodendris, 10 parts, Radix Glycyrrhizae, 5 parts of Stigma Crocis, 1 part of Radix Curcumae, 1 part of Radix Angelicae Sinensis, 10 parts, the Radix Rehmanniae, 8 parts of Folium Artemisiae Argyis, 5 parts of Ramulus Cinnamomi, 1 part of Fructus Gleditsia, 1 part of Herba Asari, 5 parts, Rhizoma Zingiberis Recens.
The above-mentioned ointment preparation process of the present invention is:
(1) by Herba Sarcandrae, Radix Notoginseng, artificial Calculus Bovis, Urena lobata Linn, Cornu Bubali, Monas cuspurpureus Went, Rhizoma Chuanxiong, Flos Carthami, Cortex Phellodendri, Stigma Croci, Radix Angelicae Sinensis, the Radix Rehmanniae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Fructus Gleditsia, Herba Asari, Rhizoma Zingiberis Recens, Hirudo and Scolopendra after washing, sterilizing and dried, carry out pulverization process, porphyrize, cross 100 mesh sieve, then decocting three times, merge three times filtrate, the concentrated extracted extract of getting angry;
(2) Flos Lonicerae, Radix Glycyrrhizae, Radix Curcumae and Radix Paeoniae Rubra drying and crushing are crossed to 100 mesh sieves, become concentrate;
(3) get Mel and be positioned over heating while stirring in container, add paraffin to continue heating, after mix homogeneously, add step (1) extractum, constantly be stirred to mix homogeneously, in the time that temperature is down to 70 DEG C, add step (2) concentrate, mix thoroughly, finally add additive.
Described Mel, for the rear Mel of refining, can effectively ensure bonding force, increases its stability.Described additive is azone, Borneolum Syntheticum, dimethyl sulfoxide, sodium benzoate, Sal, has function anticorrosion, taste masking, and guarantee medicine is preserved for a long time.
Embodiment 2
Raw material composition and the parts by weight of Ointment of the present invention are: 10 parts of Scolopendras, 10 parts of Hirudos, 25 parts of Herba Sarcandraes, 20 parts of Radix Notoginseng, 15 parts of artificial Calculus Boviss, 25 parts of Urena lobata Linn, 10 parts of Cornu Bubalis, 12 parts, Monas cuspurpureus Went, 40 parts of Flos Loniceraes, 35 parts of Radix Paeoniae Rubra, 15 parts of Rhizoma Chuanxiongs, 35 parts, Flos Carthami, 15 parts of Cortex Phellodendris, 20 parts, Radix Glycyrrhizae, 10 parts of Stigma Crocis, 2 parts of Radix Curcumaes, 2 parts of Radix Angelicae Sinensis, 8 parts, the Radix Rehmanniae, 5 parts of Folium Artemisiae Argyis, 10 parts of Ramulus Cinnamomi, 2 parts of Fructus Gleditsia, 3 parts of Herba Asaris, 10 parts, Rhizoma Zingiberis Recens.
The ointment preparation process of the present embodiment is identical with embodiment 1.
Embodiment 3
Raw material composition and the parts by weight of Ointment of the present invention are: 10 parts of Scolopendras, 10 parts of Hirudos, 40 parts of Herba Sarcandraes, 50 parts of Radix Notoginseng, 30 parts of artificial Calculus Boviss, 50 parts of Urena lobata Linn, 20 parts of Cornu Bubalis, 15 parts, Monas cuspurpureus Went, 50 parts of Flos Loniceraes, 40 parts of Radix Paeoniae Rubra, 20 parts of Rhizoma Chuanxiongs, 40 parts, Flos Carthami, 20 parts of Cortex Phellodendris, 40 parts, Radix Glycyrrhizae, 8 parts of Stigma Crocis, 2 parts of Radix Curcumaes, 4 parts of Radix Angelicae Sinensis, 5 parts, the Radix Rehmanniae, 8 parts of Folium Artemisiae Argyis, 5 parts of Ramulus Cinnamomi, 1 part of Fructus Gleditsia, 1 part of Herba Asari, 8 parts, Rhizoma Zingiberis Recens.
The ointment preparation process of the present embodiment is identical with embodiment 1.
Toxicity test
Choose 60 of rabbit, be divided into blank group, experimental group (600mg (crude drug) kg
-1), 30 every group, male and female half and half.Blank group adopts normal saline gavage, three times on the one; The dispersion liquid gavage that experimental group adopts the present embodiment 1 ointment to be dispersed in water, three times on the one, above two groups of equal successive administrations 80 days, observe the indexs such as rabbit ordinary circumstance and body weight, after last administration, blood extracting assay, puts to death after animal gross necropsy and the major organs such as the heart, liver, spleen, lung, kidney is carried out to check pathological section.
Blood result is as table 1
As can be seen from Table 1, the liver of rabbit, renal function and hemocyte inspection be all without significant difference, shows that Chinese medicine long term administration of the present invention all has no adverse effects to hemocyte and liver, renal function.
Pathological examination is not all found obvious pathological change, illustrates that Chinese medicine of the present invention can not cause tissue and organ pathological change or organic damage.
Clinical data:
1, medicinal application of the present invention is in clinical observation case 89 examples, male's 47 examples, and women's 42 examples, the age is 20-70 year.
2, usage and dosage: drug dose of the present invention is taken the circumstances into consideration increase and decrease according to weight in patients, age and symptom, and morning, noon and afternoon every day smearing ointment respectively once.
3, evaluation criterion:
Recovery from illness: inflammation disappears, blood vessel recovers elasticity, and skin colour is consistent;
Effective: swelling pain disappears gradually, clinical symptoms is obviously improved.
4, therapeutic effect: in this clinical observation case, smear 3-5 days, effective percentage reaches 91.0%, and cure rate reaches 78.6%.During treatment, there is not toxic and side effects.
5, model case:
Case 1:
Wang, female, 34 years old.After PICC venous transfusion, PICC implanting portion local pain, redness, scorching hot; Adopt drug ointment of the present invention to smear affected part 1, pain subtracts greatly; Continue to smear affected part 2, red and swollen heat pain disappears, and cures.
Case 2:
Huang, man, 54 years old.After PICC venous transfusion, PICC implanting portion local pain, redness; There is rope strip in vein, can touch scleroma; Adopt drug ointment of the present invention to smear affected part 2, pain subtracts greatly; Continue to smear affected part 3, patient PICC implanting portion red and swollen heat pain disappears, and strand runner or tuberosity disappear completely, red and swollen heat pain disappears, and cure.
Case 3:
Liu, man, 27 years old.After PICC venous transfusion, PICC implanting portion redness; There is rope strip in vein, can touch scleroma; Adopt drug ointment of the present invention to smear affected part 3, red and swollen disappearance; Continue to smear affected part 1, patient PICC implanting portion strand runner disappears completely, and it is normal that skin recovers.
The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, do not depart from technical solution of the present invention content therefore every, any simple modification, equivalent variations and the modification above embodiment done according to technical spirit of the present invention, all still belong in the scope of technical solution of the present invention.
Claims (6)
1. a treatment PICC phlebitis ointment, is characterized in that: the each component by following parts by weight forms:
10～20 parts of Scolopendras, 10～20 parts of Hirudos, 20～50 parts of Herba Sarcandraes, 10～50 parts of Radix Notoginseng, 10～30 parts of artificial Calculus Boviss, 20～50 parts of Urena lobata Linn, 10～30 parts of Cornu Bubalis, 10～20 parts, Monas cuspurpureus Went, 30～50 parts of Flos Loniceraes, 30～50 parts of Radix Paeoniae Rubra, 10～20 parts of Rhizoma Chuanxiongs, 30～50 parts, Flos Carthami, 10～20 parts of Cortex Phellodendris, 10～50 parts, Radix Glycyrrhizae, 5～15 parts of Stigma Crocis, 1～10 part of Radix Curcumae, 1～10 part of Radix Angelicae Sinensis, 1～10 part, the Radix Rehmanniae, 1～10 part of Folium Artemisiae Argyi, 1～10 part of Ramulus Cinnamomi, 1～10 part of Fructus Gleditsia, 1～10 part of Herba Asari, 1～10 part, Rhizoma Zingiberis Recens.
2. one according to claim 1 is treated PICC phlebitis ointment, is made up of each component of following parts by weight:
10～20 parts of Scolopendras, 10～20 parts of Hirudos, 20～40 parts of Herba Sarcandraes, 20～50 parts of Radix Notoginseng, 10～30 parts of artificial Calculus Boviss, 20～50 parts of Urena lobata Linn, 10～30 parts of Cornu Bubalis, 10～20 parts, Monas cuspurpureus Went, 30～50 parts of Flos Loniceraes, 30～50 parts of Radix Paeoniae Rubra, 10～20 parts of Rhizoma Chuanxiongs, 40～50 parts, Flos Carthami, 10～15 parts of Cortex Phellodendris, 10～40 parts, Radix Glycyrrhizae, 5～10 parts of Stigma Crocis, 1～5 part of Radix Curcumae, 1～5 part of Radix Angelicae Sinensis, 1～5 part, the Radix Rehmanniae, 1～5 part of Folium Artemisiae Argyi, 1～5 part of 1～5 part of Fructus Gleditsia of Ramulus Cinnamomi, 1～5 part of Herba Asari, 1～5 part, Rhizoma Zingiberis Recens.
3. one according to claim 1 is treated PICC phlebitis ointment, it is characterized in that: the each component by following parts by weight forms: 10 parts of Scolopendras, 10 parts of Hirudos, 20 parts of Herba Sarcandraes, 15 parts of Radix Notoginseng, 10 parts of artificial Calculus Boviss, 20 parts of Urena lobata Linn, 30 parts of Cornu Bubalis, 10 parts, Monas cuspurpureus Went, 30 parts of Flos Loniceraes, 30 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Chuanxiongs, 30 parts, Flos Carthami, 10 parts of Cortex Phellodendris, 10 parts, Radix Glycyrrhizae, 5 parts of Stigma Crocis, 1 part of Radix Curcumae, 1 part of Radix Angelicae Sinensis, 10 parts, the Radix Rehmanniae, 8 parts of Folium Artemisiae Argyis, 5 parts of Ramulus Cinnamomi, 1 part of Fructus Gleditsia, 1 part of Herba Asari, 5 parts, Rhizoma Zingiberis Recens.
4. a treatment PICC phlebitis ointment machin its preparation method, is characterized in that: comprise following processing step:
(1) by Herba Sarcandrae, Radix Notoginseng, artificial Calculus Bovis, Urena lobata Linn, Cornu Bubali, Monas cuspurpureus Went, Rhizoma Chuanxiong, Flos Carthami, Cortex Phellodendri, Stigma Croci, Radix Angelicae Sinensis, the Radix Rehmanniae, Folium Artemisiae Argyi, Ramulus Cinnamomi, Fructus Gleditsia, Herba Asari, Rhizoma Zingiberis Recens, Hirudo and Scolopendra after washing, sterilizing and dried, carry out pulverization process, porphyrize, cross 100 mesh sieves, then decocting three times, merge three times filtrate, the concentrated extracted extract of getting angry;
(2) Flos Lonicerae, Radix Glycyrrhizae, Radix Curcumae and Radix Paeoniae Rubra drying and crushing are crossed to 100 mesh sieves, become concentrate;
(3) get Mel and be positioned over heating while stirring in container, add paraffin to continue heating, after mix homogeneously, add step (1) extractum, constantly be stirred to mix homogeneously, in the time that temperature is down to 70 DEG C, add step (2) concentrate, mix thoroughly, finally add additive, stir, get product.
5. treat PICC phlebitis ointment machin its preparation method according to the one described in claim 4, it is characterized in that: described Mel is the rear Mel of refining.
6. treat PICC phlebitis ointment machin its preparation method according to the one described in claim 4, it is characterized in that: described additive is azone, Borneolum Syntheticum, dimethyl sulfoxide, sodium benzoate, Sal.
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| CN105709195A (en) * | 2016-03-25 | 2016-06-29 | 于向英 | Traditional Chinese medicine paste for preventing and treating PICC phlebitis and phlebothrombosis |
| CN105796625A (en) * | 2014-12-31 | 2016-07-27 | 北京北大维信生物科技有限公司 | Pharmaceutical composition containing red yeast rice and safflower and preparation thereof |
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| CN102727641A (en) * | 2012-07-13 | 2012-10-17 | 孙红梅 | External traditional Chinese medicine for treating superficial phlebitis |
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| CN103385984A (en) * | 2012-05-07 | 2013-11-13 | 马同山 | Traditional Chinese medicine composition for treating phlebitis |
| CN102657818A (en) * | 2012-05-10 | 2012-09-12 | 张丽 | Drug for treating infusion phlebitis and preparation method thereof |
| CN102727641A (en) * | 2012-07-13 | 2012-10-17 | 孙红梅 | External traditional Chinese medicine for treating superficial phlebitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105796625A (en) * | 2014-12-31 | 2016-07-27 | 北京北大维信生物科技有限公司 | Pharmaceutical composition containing red yeast rice and safflower and preparation thereof |
| CN105709195A (en) * | 2016-03-25 | 2016-06-29 | 于向英 | Traditional Chinese medicine paste for preventing and treating PICC phlebitis and phlebothrombosis |
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Application publication date: 20140827 |