CN110090251B - Preparation method of artemisia capillaris tablet - Google Patents
Preparation method of artemisia capillaris tablet Download PDFInfo
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Abstract
The invention relates to a preparation method of artemisia capillaris tablet, which comprises the following steps: (1) extracting herba Artemisiae Scopariae with ethanol, purifying with macroporous resin, and drying to obtain dry extract; (2) extracting fructus Gardeniae with water, purifying with macroporous resin, and drying to obtain dry extract; (3) extracting radix et rhizoma Rhei with water, precipitating with ethanol, concentrating the supernatant, extracting with ethyl acetate, concentrating, precipitating with ethanol, and drying to obtain radix et rhizoma Rhei extract dry extract; (4) mixing the extract dry extract powder with adjuvants; (5) granulating; (6) tabletting; (7) the prepared artemisia capillaris tablet is convenient to carry and store, convenient to take, good in particle fluidity, high in transfer rate of effective components of a finished product and stable in quality.
Description
Technical Field
The invention relates to a preparation method of a Chinese medicinal preparation, namely artemisia capillaris tablet.
Background
Cholestatic liver diseases caused by various reasons belong to the category of jaundice in traditional Chinese medicine. Damp-heat accumulated in the middle energizer fumigates the liver and gallbladder, causing liver dysfunction and bile overflow, which is the basic etiology and pathogenesis. The location of the disease is mainly in the liver, gallbladder, spleen and stomach, and also in the kidney after a long period of disease. It is usually treated by clearing heat and promoting diuresis, promoting blood circulation by removing blood stasis, cooling blood, resolving phlegm, etc.
The currently common oral jaundice-removing medicines in clinic mainly comprise Yinzhihuang effervescent tablets (oral liquid), jaundice virgate wormwood granules and the like. YINZHIHUANG is herba Artemisiae Scopariae extract, fructus Gardeniae extract, baicalin, and flos Lonicerae extract, and HUANGHUAYINCHEN granule is prepared from herba Artemisiae Scopariae, Scutellariae radix, radix et rhizoma Rhei (preparata), and Glycyrrhrizae radix, and has effects of clearing heat, promoting diuresis, and eliminating jaundice. Can be used for treating acute and chronic infectious icterohepatitis. Both of them are not traditional classical formula, mainly have the main effects of clearing heat and removing toxicity, lack the effect of removing blood stasis, do not embody the action characteristics of traditional meridian formula, and limit the improvement of clinical curative effect of traditional Chinese medicine.
Aiming at the disease, the modern hospitals are lack of effective treatment medicines at present. The commonly used clinical S-adenosine-L-methionine (butanedisulfonic acid ademetionine) enteric-coated tablet and ursodeoxycholic acid, etc., the former can reduce bilirubin to a certain extent, but has no obvious effect on patients with mild increase of total bilirubin of chronic liver diseases and has high price. The latter is mainly characterized by the reduction of GGT and AKP, and the effect of reducing bilirubin is limited. The two medicines are obviously weaker than the traditional Chinese medicine in the aspects of improving the clinical symptoms of patients and relieving the pain of the patients.
The artemisia capillaris decoction is firstly recorded in Shang Han Lun of Zhang Zhongjing in the Han Dynasty, is a first-choice prescription for clinically treating yang-jaundice, and is advocated by past physicians. The original formula of the artemisia capillaris decoction comprises six to two artemisia capillaris, fourteen gardenias and two rhubarb. Clinical and experimental researches show that the artemisia capillaries soup has the effects of promoting bilirubin metabolism, resisting liver injury, inhibiting hepatocyte apoptosis, inhibiting stellate cell activation and collagen synthesis. Three models, namely a bile duct ligation model, a DMN model and the like, are used for verifying that the artemisia capillaris decoction has obvious functions of benefiting gallbladder, removing jaundice, reducing enzyme and protecting liver in the early stage of a subject group. However, the decoction is inconvenient to carry.
Disclosure of Invention
The purpose of the invention is as follows: on the premise of ensuring the curative effect, the preparation method of the artemisia capillaris tablet is provided for the convenience of carrying, storage and taking.
The technical scheme is as follows:
a method for preparing artemisia capillaries slice, artemisia capillaries slice is prepared by extracting rhubarb, artemisia capillaris and gardenia, the method comprises the following steps: (1) extracting radix et rhizoma Rhei with water, precipitating with ethanol, concentrating the supernatant, extracting with ethyl acetate, concentrating, precipitating with ethanol, and drying to obtain radix et rhizoma Rhei extract dry extract; (2) extracting herba Artemisiae Scopariae with ethanol, purifying with macroporous resin, and drying to obtain dry extract; (3) extracting fructus Gardeniae with water, purifying with macroporous resin, and drying to obtain fructus Gardeniae extract dry extract; (4) mixing the three prepared dry extracts with adjuvants, and granulating; (5) tabletting; (6) and (4) coating.
The preparation method comprises the steps of (1) extracting rheum officinale with water for 3 times, each time lasting for 1.5 hours, adding 10 times of water for the first time, adding 8 times of water for the other two times, combining extracting solutions, concentrating until the relative density is 1.10-1.15 at 60 ℃, cooling to room temperature, adding 4 times of 95% ethanol, standing for 24 hours, precipitating for later use, concentrating supernate to the relative density of 1.10-1.15 at 60 ℃, extracting with equal volume of ethyl acetate for 4 times, taking an ethyl acetate layer, recovering ethyl acetate to obtain a gallic acid part, mixing the gallic acid part with an alcohol precipitation, and drying.
The preparation method comprises the steps of extracting the oriental wormwood in the step (2) with 75% ethanol for 2 times, wherein each time is 1 hour, adding 12 times of solvent for the first time, soaking for 2 hours, adding 8 times of solvent for the second time, combining the extracting solutions for 2 times, concentrating under reduced pressure, recovering ethanol until no alcohol smell exists, adding water to dilute until the density is 0.1g of crude drug/ml, filtering with a 200-mesh gauze, standing, taking the supernatant, sampling with an HPD200A macroporous resin column at the sampling speed of less than or equal to 1BV/h, washing with 1BV after sampling is finished, eluting with 50% ethanol at the speed of less than or equal to 1BV/h for 3BV, collecting the eluent, concentrating under reduced pressure at 60 ℃ until the density is 1.22-1.26g/ml, drying under reduced pressure.
The preparation method comprises the steps of (3) extracting the gardenia by using water, crushing the gardenia into coarse powder, extracting the coarse powder by using the water for 3 times, soaking the coarse powder for 1 hour for the first time by using 14 times of water for 2 hours, adding 10 times of water for the other two times, combining the extracting solutions for 3 times, loading the HPD200A macroporous resin on a macroporous resin column, washing the macroporous resin column by using the water until the macroporous resin column is colorless, eluting the macroporous resin column by using 5BV 50% ethanol at the speed of less than or equal to 3BV/h, concentrating the macroporous resin column under reduced pressure, recovering the ethanol until the density is 1.22 to 1.26g/ml, drying the mixture under reduced pressure at the temperature of 60 ℃, and crushing the mixture.
The preparation method comprises the steps of (1) mixing the 3 dry extracts in the step (4), adding microcrystalline cellulose, polyvinylpyrrolidone K30 and low-substituted hydroxypropyl fiber, and performing dry granulation by adopting the following process parameters: the technological parameters are controlled as follows: the granulation parameters were as follows: a feeding motor: 4-12 Hz; a tablet pressing motor: 12-22 Hz; a crushing motor: 5-15 Hz; a whole grain motor: 12 to 22 Hz.
The preparation method comprises the step (6) of coating, wherein the parameters of a coating machine are as follows: material temperature: 40-43 ℃; air inlet temperature: 70-83 ℃; air outlet temperature: 50-80 ℃; the rotating speed of the fan is as follows: 800-1200 rpm; atomization pressure: 1.5 to 3 MPa.
In the preparation method, the artemisia capillaris tablet is prepared by extracting the following medicinal materials in parts by weight: 5-9 parts of rheum officinale, 12-15 parts of oriental wormwood and 3-9 parts of gardenia.
Has the advantages that: the prepared granules have good fluidity, high transfer rate of effective components of the finished product and stable quality.
Detailed Description
Example 1: taking 5 parts of rhubarb, 15 parts of oriental wormwood and 3 parts of gardenia, and the preparation method comprises the following steps:
reflux-extracting radix et rhizoma Rhei with water for 2 times, 1 hr each time, 6 times of water each time, adding 1 times of water for the first time, filtering, mixing filtrates, concentrating to density of 1.10g/ml (60 deg.C), cooling, adding 2 times of ethanol, and precipitating with ethanol for 12 hr. Precipitating with ethanol, recovering ethanol from the supernatant under reduced pressure until no ethanol smell (density of 1.15g/ml (60 deg.C)), extracting with 1 times volume of ethyl acetate for 2 times, mixing the ethyl acetate layer extractive solutions, recovering ethyl acetate to obtain gallic acid part, mixing with the precipitate, drying under reduced pressure (60 deg.C), and pulverizing to obtain extract 1.
Extracting herba Artemisiae Scopariae with 60% ethanol for 1 time, each time for 1 hr, soaking in 10 times of solvent for 1 hr, adding 7 times of solvent for the second time, mixing extractive solutions, concentrating under reduced pressure, recovering ethanol until no alcohol smell exists, diluting with water to density of 0.1g crude drug/ml, filtering with 200 mesh gauze, standing, collecting supernatant, sampling with HPD200A macroporous resin column at sampling speed of not more than 1BV/h, washing with water after sampling for 1BV, eluting with 40% ethanol at speed of not more than 1BV/h for 3BV, collecting eluate, concentrating under reduced pressure at 60 deg.C to density of 1.22g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 2.
Pulverizing fructus Gardeniae into coarse powder, extracting with water for 2 times (each time for 1 hr), adding 12 times of water for the first time, adding 8 times of water for the other two times, mixing the extractive solutions for 3 times, loading with macroporous resin column (HPD200A macroporous resin, diameter-height ratio of 1:7), loading speed of not more than 1BV/h, washing with water to colorless, eluting with 3BV 50% ethanol at speed of not more than 1BV/h, concentrating under reduced pressure, recovering ethanol to density of 1.22g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 3.
Mixing the 3 extracts, adding appropriate amount of microcrystalline cellulose, 3% polyvinylpyrrolidone K30, and 1% low-substituted hydroxypropyl cellulose, mixing, and granulating.
After granulation, 1% of magnesium stearate is added, the mixture is uniformly mixed by a three-dimensional mixer, and the weight of each tablet is 0.6g, which is equivalent to 3.8g of the original medicinal material.
Coating with gastric soluble film coating premix, and increasing weight by 1%. The parameters of the coating machine are as follows:
material temperature: 40-43 deg.C
Air inlet temperature: 70 deg.C
Air outlet temperature: 50-80 DEG C
The rotating speed of the fan is as follows: 800 rpm.
Example 2: the preparation method comprises the following steps of taking 9 parts of rhubarb, 12 parts of oriental wormwood and 9 parts of cape jasmine fruit:
reflux-extracting radix et rhizoma Rhei with water for 4 times, 2 hr each time, 10 times of water each time, adding 2 times of water for the first time, filtering, mixing filtrates, concentrating to density of 1.15g/ml (60 deg.C), cooling, adding 6 times of ethanol, and precipitating with ethanol for 36 hr. Precipitating with ethanol, recovering ethanol from the supernatant under reduced pressure until no ethanol smell (density of 1.15g/ml (60 deg.C)), extracting with 3 times volume of ethyl acetate for 6 times, mixing the ethyl acetate layer extractive solutions, recovering ethyl acetate to obtain gallic acid part, mixing with the precipitate, drying under reduced pressure (60 deg.C), and pulverizing to obtain extract 1.
Extracting herba Artemisiae Scopariae with 90% ethanol for 3 times, each for 2 hr, soaking in 12 times of solvent for 2 hr, adding 9 times of solvent for the second time, mixing extractive solutions, concentrating under reduced pressure, recovering ethanol until no alcohol smell exists, diluting with water to density of 0.3g crude drug/ml, filtering with 200 mesh gauze, standing, collecting supernatant, sampling with HPD200A macroporous resin column at sampling speed of 3BV/h or less, washing with water after sampling to 3BV, eluting with 60% ethanol at speed of 3BV/h or less to 5BV, collecting eluate, concentrating under reduced pressure at 60 deg.C to density of 1.26g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 2.
Pulverizing fructus Gardeniae into coarse powder, extracting with water for 4 times (each for 2 hr), soaking in 14 times of water for 2 hr, adding 12 times of water in the rest two times, mixing the extractive solutions for 3 times, loading with macroporous resin column (HPD200A macroporous resin, diameter-height ratio of 1:7), loading speed of no more than 3BV/h, washing with water to colorless, eluting with 7BV 70% ethanol at no more than 3BV/h, concentrating under reduced pressure, recovering ethanol to density of 1.26g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 3.
Mixing the 3 extracts, adding appropriate amount of microcrystalline cellulose, 7% polyvinylpyrrolidone K30, and 5% low-substituted hydroxypropyl cellulose, mixing, and granulating.
The granulation parameters were as follows:
a feeding motor: 12Hz
A tablet pressing motor: 22Hz
A crushing motor: 15Hz
A whole grain motor: 22Hz
After granulation, 1% of magnesium stearate is added, the mixture is uniformly mixed by a three-dimensional mixer, and the weight of each tablet is 0.6g, which is equivalent to 3.8g of the original medicinal material.
Coating with a gastric-soluble film coating premix, wherein the weight is increased by 1-3%. The parameters of the coating machine are as follows:
material temperature: 40-43 deg.C
Air inlet temperature: 83 deg.C
Air outlet temperature: 50-80 DEG C
The rotating speed of the fan is as follows: 1200rpm
Atomization pressure: 3 MPa.
Example 3: taking 6 parts of rhubarb, 12 parts of oriental wormwood and 6 parts of gardenia, and the preparation method comprises the following steps:
reflux-extracting radix et rhizoma Rhei with water for 3 times, 1.5 hr each time, 8 times of water for the first time, adding 2 times of water for the first time, filtering, mixing filtrates, concentrating to density of 1.15g/ml (60 deg.C), cooling, adding 4 times volume of ethanol, and precipitating with ethanol for 24 hr. Precipitating with ethanol, recovering ethanol from the supernatant under reduced pressure until no ethanol smell (density of 1.10g/ml (60 deg.C)), extracting with ethyl acetate for 3 times, mixing the extractive solutions, recovering ethyl acetate to obtain gallic acid fraction, mixing with the precipitate, drying under reduced pressure (60 deg.C), and pulverizing to obtain extract 1.
Extracting herba Artemisiae Scopariae with 70% ethanol for 2 times, each for 1.5 hr, soaking in 11 times of solvent for 1.5 hr, adding 8 times of solvent for the second time, mixing extractive solutions, concentrating under reduced pressure, recovering ethanol until no alcohol smell exists, diluting with water to density of 0.2g crude drug/ml, filtering with 200 mesh gauze, standing, collecting supernatant, loading onto HPD200A macroporous resin column at loading speed of not more than 2BV/h, washing with water after loading, eluting with 45% ethanol at speed of not more than 2BV/h for 4BV, collecting eluate, concentrating under reduced pressure at 60 deg.C to density of 1.24g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 2.
Pulverizing fructus Gardeniae into coarse powder, extracting with water for 3 times, each for 1.5 hr, soaking with 12 times of water for 1 hr, adding 10 times of water for the other two times, mixing the 3 times of extractive solutions, loading with macroporous resin column (HPD200A macroporous resin, diameter-height ratio of 1:7), loading speed of no more than 2BV/h, washing with water to colorless, eluting with 6BV 55% ethanol at no more than 1.5BV/h, concentrating under reduced pressure, recovering ethanol to density of 1.24g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 3.
Mixing the 3 extracts, adding appropriate amount of microcrystalline cellulose, 4% polyvinylpyrrolidone K30, and 3% low-substituted hydroxypropyl cellulose, mixing, and granulating.
The granulation parameters were as follows:
a feeding motor: 8Hz
A tablet pressing motor: 16Hz
A crushing motor: 10Hz
A whole grain motor: 18Hz
After granulation, 1% of magnesium stearate is added, the mixture is uniformly mixed by a three-dimensional mixer, and the weight of each tablet is 0.6g, which is equivalent to 3.8g of the original medicinal material.
Coating with gastric soluble film coating premix, and increasing weight by 2%. The parameters of the coating machine are as follows:
material temperature: 40-43 deg.C
Air inlet temperature: 78 deg.C
Air outlet temperature: 50-80 DEG C
The rotating speed of the fan is as follows: 1000rpm
Atomization pressure: 2.2 MPa.
Example 4: the preparation method comprises the following steps of taking 9 parts of rhubarb, 15 parts of oriental wormwood and 3 parts of gardenia, and comprises the following steps:
reflux-extracting radix et rhizoma Rhei with water for 3 times, 1.5 hr each time, 8 times of water for the first time, adding 2 times of water for the first time, filtering, mixing filtrates, concentrating to density of 1.12g/ml (60 deg.C), cooling, adding 4 times volume of ethanol, and precipitating with ethanol for 24 hr. Precipitating with ethanol, recovering ethanol from the supernatant under reduced pressure until no ethanol smell (density of 1.12g/ml (60 deg.C)), extracting with 1 times volume of ethyl acetate for 4 times, mixing the ethyl acetate layer extractive solutions, recovering ethyl acetate to obtain gallic acid part, mixing with the precipitate, drying under reduced pressure (60 deg.C), and pulverizing to obtain extract 1.
Extracting herba Artemisiae Scopariae with 75% ethanol for 2 times, each for 1 hr, soaking in 10 times of solvent for 2 hr, adding 8 times of solvent for the second time, mixing extractive solutions, concentrating under reduced pressure, recovering ethanol until no alcohol smell exists, diluting with water to density of 0.1g crude drug/ml, filtering with 200 mesh gauze, standing, collecting supernatant, sampling with HPD200A macroporous resin column at sampling speed of 1BV/h or less, washing with water after sampling to 1BV, eluting with 50% ethanol at speed of 1BV/h or less for 3BV, collecting eluate, concentrating under reduced pressure at 60 deg.C to density of 1.25g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 2.
Pulverizing fructus Gardeniae into coarse powder, extracting with water for 3 times (each for 1 hr), soaking in 14 times of water for 2 hr, adding 10 times of water in the rest two times, mixing the extractive solutions for 3 times, loading with macroporous resin column (HPD200A macroporous resin, diameter-height ratio of 1:7), loading speed of no more than 3BV/h, washing with water to colorless, eluting with 5BV 50% ethanol at no more than 3BV/h, concentrating under reduced pressure, recovering ethanol to density of 1.25g/ml, drying under reduced pressure at 60 deg.C, and pulverizing to obtain extract 3.
Mixing the 3 extracts, adding appropriate amount of microcrystalline cellulose, 5% polyvinylpyrrolidone K30, and 3% low-substituted hydroxypropyl cellulose, mixing, and granulating.
The granulation parameters were as follows:
a feeding motor: 8Hz
A tablet pressing motor: 18Hz
A crushing motor: 10Hz
A whole grain motor: 18Hz
After granulation, 1% of magnesium stearate is added, the mixture is uniformly mixed by a three-dimensional mixer, and the weight of each tablet is 0.6g, which is equivalent to 3.8g of the original medicinal material.
Coating with gastric soluble film coating premix, and increasing weight by 3%. The parameters of the coating machine are as follows:
material temperature: 40-43 deg.C
Air inlet temperature: 83 deg.C
Air outlet temperature: 50-80 DEG C
The rotating speed of the fan is as follows: 1200rpm
Atomization pressure: 2.5 MPa.
Example 5: formulation process investigation
(1) Selection of granulation Process
According to the combination of the preparation process characteristics of the tablets and the prescription amount, as the raw materials are all powder, the extract has larger specific gravity and the auxiliary material space amount is narrow, the granulation technology is selected to improve the material fluidity, so as to be beneficial to tabletting; compared with the wet granulation method and the dry granulation method, the mixed extract contains water-soluble components such as polysaccharide and the like, has larger hygroscopicity, and is easy to adhere to a screen mesh in the wet granulation process and difficult to form. Dry granulation was therefore selected with the addition of binder povidone K30. The result of comparison and investigation of the proportion of microcrystalline cellulose MCC as a filler and polyvinylpyrrolidone K30 as a binder in the auxiliary materials shows that the proportion of 75 to 25 percent can ensure that the material has better fluidity.
TABLE 1 examination of granulation Process
TABLE 2 examination of the proportion of filler and binder in the adjuvants
Ratio of filler MCC to binder K30 | 50%︰50% | 75%︰25% | 100%︰0% |
Angle of repose | 41° | 47° | 37° |
(2) Selecting auxiliary materials: in order to enable the active component to have better bioavailability and better preparation characteristics, the investigation conditions such as the type and the dosage of the auxiliary materials are selected, and the type and the dosage of the auxiliary materials are investigated by taking the disintegration time limit of the tablet as an index. Finally, a proper amount of microcrystalline cellulose, 5 percent of polyvinylpyrrolidone K30 and 3 percent of low-substituted hydroxypropyl cellulose are selected as granulation auxiliary materials. Meanwhile, in order to ensure that the surface of the pressed tablet is smooth and avoid sticking, 1% of lubricant magnesium stearate is added after granulation for tabletting.
TABLE 3 comparison of disintegration time before and after addition of disintegrant
Without disintegrating agent (n ═ 6) | 3% Low-substituted hydroxypropylcellulose (n ═ 6) | 3% sodium starch glycolate (n ═ 6) | |
Disintegration time>1h | 3 | 0 | 0 |
Disintegration time>0.5h,<1h | 3 | 0 | 3 |
Disintegration time<0.5h | 0 | 6 | 3 |
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And such obvious changes and modifications which fall within the spirit of the invention are deemed to be covered by the present invention.
Claims (2)
1. A preparation method of artemisia capillaries slice is characterized in that the artemisia capillaries slice is prepared by extracting rhubarb, oriental wormwood and gardenia jasminoides, and the method comprises the following steps: (1) extracting radix et rhizoma Rhei with water, precipitating with ethanol, concentrating the supernatant, extracting with ethyl acetate, concentrating, precipitating with ethanol, and drying to obtain radix et rhizoma Rhei extract dry extract; (2) extracting herba Artemisiae Scopariae with ethanol, purifying with macroporous resin, and drying to obtain dry extract; (3) extracting fructus Gardeniae with water, purifying with macroporous resin, and drying to obtain fructus Gardeniae extract dry extract; (4) mixing the three prepared dry extracts with adjuvants, and granulating; (5) tabletting; (6) coating; extracting the rheum officinale water in the step (1) for 3 times, each time lasts for 1.5 hours, adding 10 times of water for the first time, adding 8 times of water for the other two times, combining extracting solutions, concentrating until the relative density at 60 ℃ is 1.10-1.15, cooling to room temperature, adding 4 times of 95% ethanol, standing for 24 hours, precipitating for later use, concentrating supernate to the relative density at 60 ℃ of 1.10-1.15, extracting for 4 times by using ethyl acetate with the same volume, taking an ethyl acetate layer, recovering ethyl acetate to obtain a gallic acid part, mixing the gallic acid part with an alcohol precipitation, and drying; extracting the oriental wormwood in the step (2) with 75% ethanol for 2 times, each time for 1 hour, adding 12 times of solvent for the first time, soaking for 2 hours, adding 8 times of solvent for the second time, combining the extracting solutions for 2 times, concentrating under reduced pressure, recovering ethanol until no alcohol smell exists, adding water to dilute until the density is 0.1g of crude drug/ml, filtering with a 200-mesh gauze, standing, taking the supernatant, sampling with an HPD200A macroporous resin column at the sampling speed of less than or equal to 1BV/h, washing with water after sampling for 1BV, eluting with 50% ethanol at the speed of less than or equal to 1BV/h for 3BV, collecting the eluent, concentrating under reduced pressure at 60 ℃ until the density is 1.22-1.26g/ml, drying under reduced pressure at 60 ℃, and; extracting the gardenia jasminoides in the step (3) by using water, crushing the gardenia jasminoides into coarse powder, extracting the coarse powder by using water for 3 times, wherein each time is 1 hour, the first time is 14 times of water and soaking the coarse powder for 2 hours, the other two times are added with 10 times of water, extracting solutions for 3 times are combined, a macroporous resin column is loaded with HPD200A macroporous resin, the diameter-height ratio is 1:7, the loading speed is less than or equal to 3BV/h, the loading is washed by using water till the sample is colorless, 5BV 50% ethanol is used for eluting at the speed of less than or equal to 3BV/h, concentrating under reduced pressure, recovering the ethanol till the density is 1.22-; mixing the 3 dry extracts obtained in the step (4), adding microcrystalline cellulose, polyvinylpyrrolidone K30 and low-substituted hydroxypropyl fiber, and performing dry granulation by adopting the following process parameters: a feeding motor: 4-12 Hz; a tablet pressing motor: 12-22 Hz; a crushing motor: 5-15 Hz; a whole grain motor: 12-22 Hz; and (6) coating, wherein the parameters of a coating machine are as follows: material temperature: 40-43 ℃; air inlet temperature: 70-83 ℃; air outlet temperature: 50-80 ℃; the rotating speed of the fan is as follows: 800-1200 rpm; atomization pressure: 1.5 to 3 MPa.
2. The preparation method of claim 1, wherein the artemisia capillaris tablet is prepared by extracting the following medicinal materials in parts by weight: 5-9 parts of rheum officinale, 12-15 parts of oriental wormwood and 3-9 parts of gardenia.
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CN101371882A (en) * | 2007-08-24 | 2009-02-25 | 曾雄辉 | Method for preparing Artemisia capillaris decoction formulation |
CN101407532A (en) * | 2008-11-24 | 2009-04-15 | 浙江省中药研究所有限公司 | Method for preparing gardenin from gardenia |
CN101940642A (en) * | 2010-10-08 | 2011-01-12 | 华东理工大学 | Chinese medicinal composition and application thereof |
CN102309579A (en) * | 2011-09-16 | 2012-01-11 | 陕西科技大学 | Tarragon soup effervescent tablet and its preparation method |
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CN101371882A (en) * | 2007-08-24 | 2009-02-25 | 曾雄辉 | Method for preparing Artemisia capillaris decoction formulation |
CN101407532A (en) * | 2008-11-24 | 2009-04-15 | 浙江省中药研究所有限公司 | Method for preparing gardenin from gardenia |
CN101940642A (en) * | 2010-10-08 | 2011-01-12 | 华东理工大学 | Chinese medicinal composition and application thereof |
CN102309579A (en) * | 2011-09-16 | 2012-01-11 | 陕西科技大学 | Tarragon soup effervescent tablet and its preparation method |
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