CN102309579A - Tarragon soup effervescent tablet and its preparation method - Google Patents
Tarragon soup effervescent tablet and its preparation method Download PDFInfo
- Publication number
- CN102309579A CN102309579A CN201110274574A CN201110274574A CN102309579A CN 102309579 A CN102309579 A CN 102309579A CN 201110274574 A CN201110274574 A CN 201110274574A CN 201110274574 A CN201110274574 A CN 201110274574A CN 102309579 A CN102309579 A CN 102309579A
- Authority
- CN
- China
- Prior art keywords
- herba artemisiae
- artemisiae scopariae
- effervescent tablet
- soup
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a tarragon soup effervescent tablet and its preparation method. According to the invention, traditional Chinese medicinal prescriptions are developed by a modern preparation technology and a decoction of the tarragon soup is prepared into the effervescent tablet. The weight of the prepared tarragon soup effervescent tablet is 1g; the hardness is 5.5-6kg; the disintegration time is 180-190s; after disintegration, the solution is clear with no sediment residue, pH is 5.0-5.5 and the foam volume is 8-9 mL. The prepared effervescent tablet conforms to pharmacopoeia provisions. By a method of wrapping an alkaline agent with the use of polyethylene glycol, the alkaline agent is effectively isolated from an acid inhibitor, and the problem of poor stability of the effervescent tablet is solved. In addition, the preparation technology is simple; the prepared effervescent tablet is not easy to absorb moisture, has a non-deformable appearance and a good taste, and is rapid to dissolve and convenient to store, transport and carry.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, relate to Herba Artemisiae Scopariae soup effervescent tablet and preparation method thereof.
Background technology
Herba Artemisiae Scopariae Decoction has another name called Herba Artemisiae Scopariae soup, comes from " Treatise on Febrile and Miscellaneous Disease ", write out a prescription by Herba Artemisiae Scopariae 700g, and Fructus Gardeniae 170g, Radix Et Rhizoma Rhei 230g forms, and ability clearing away heat-damp and promoting diuresis, detoxifcation jaundice eliminating are mainly used in treatment jaundice due to damp-heat disease.Modern pharmacological research shows, effect such as Herba Artemisiae Scopariae soup has function of gallbladder promoting, protects the liver, analgesic, antiinflammatory, analgesia, antibiotic and antiviral.It is the main pharmacological basis of the multiple jaundice of our clinical treatment and infectious hepatitis, acute hepatitis, acute viral hepatitis, hepatitis gravis that function of gallbladder promoting protects the liver.The agent of tradition Herba Artemisiae Scopariae rushing, oral dose is big, bitter and puckery flavor, takes, carries inconvenience, and is difficult for preserving, and can not satisfy modern's medication requirement.
Summary of the invention
The object of the present invention is to provide a kind of carrying and the Chinese medicine preparation Herba Artemisiae Scopariae soup effervescent tablet of taking convenience and preparation method thereof.
The present invention carries out the exploitation of modern preparation technique to Chinese medicine name side, and effervescent tablet is processed in the agent of Herba Artemisiae Scopariae rushing, utilizes the method for Polyethylene Glycol parcel alkaline agent effectively to isolate itself and the contacting of sour agent, and has solved the problem of effervescent tablet poor stability.
For realizing above-mentioned purpose, the present invention has adopted following technical scheme:
Herba Artemisiae Scopariae soup effervescent tablet, the prescription of this Herba Artemisiae Scopariae soup effervescent tablet (1000) composed of the following components:
The method for preparing of Herba Artemisiae Scopariae soup effervescent tablet may further comprise the steps:
(1) 50～100g lubricant is added 150～350g alkaline agent, stir, cooling is pulverized, and crosses 80～120 mesh sieves, gets wrappage;
(2) sour agent, filler are crossed 80～120 mesh sieves respectively;
(3) with 200～400g acid agent, 190～250g filler, wrappage, 0～80g sweeting agent mixing, add 120～180g Herba Artemisiae Scopariae soup extractum, granulate;
(4) granulation after drying, granulate, spray into 0～50g aromatic, dry then, tabletting;
(5) through being up to the standards, packing promptly gets Herba Artemisiae Scopariae soup effervescent tablet.
The method for distilling of said Herba Artemisiae Scopariae soup extractum decocts 1～2h for the water logging bubble back that the Herba Artemisiae Scopariae medical material is added 8-10 times of quality; Add Fructus Gardeniae and Radix Et Rhizoma Rhei then; The water that adds 10 times of quality of Herba Artemisiae Scopariae medical material again continue to decoct 1～2h and gets decocting liquid, decocting liquid is left standstill, filters the back concentrates, cooling, and the cooling back adds ethanol to be made and contain the alcohol amount and reach 70～80% (volume fractions); Leave standstill then, filtering and impurity removing, concentrated filtrate gets the Herba Artemisiae Scopariae soup extractum that density is 1.2～1.5g/ml after the remove impurity.
Said soak time is 0.5～2h, and the time of leaving standstill is 6～12h, Herba Artemisiae Scopariae: Fructus Gardeniae: the weight ratio of Radix Et Rhizoma Rhei is 70: 17: 23.
Said lubricant is a kind of or mixture in polyethylene glycol 6000, the Macrogol 4000, and alkaline agent is a kind of or mixture in sodium carbonate or the sodium bicarbonate.
The mixture of one or more in said sour agent selection tartaric acid, citric acid or the adipic acid, the mixture of one or more in filler selection lactose, sucrose, mannitol or the sorbitol.
The mixture of one or more in said sweeting agent selection aspartame, sucrose, steviosin or the disodium glycyrrhizinate.
Said aromatic is selected orange flavor, Fructus Citri Limoniae essence or flavoring pineapple essence.
The Herba Artemisiae Scopariae soup effervescent tablet sheet of this method for preparing preparation heavily is 1g (per day for adults is taken Herba Artemisiae Scopariae soup effervescent tablet 3 times, each 3), and hardness is 5.5～6kg; Be 180～190s disintegration, solution clarification after the disintegrate, and deposit-free is residual; PH is 5.0～5.5, and gas release is 8～9mL, meets the pharmacopeia regulation.
Compared with prior art; The present invention has following technique effect: Herba Artemisiae Scopariae soup effervescent tablet according to the invention and preparation method thereof, Chinese medicine name side is carried out modern preparation technique exploitation, and at first Herba Artemisiae Scopariae soup extractum is processed in the agent of Herba Artemisiae Scopariae rushing; Prepare effervescent tablet with Herba Artemisiae Scopariae soup extractum then; Through modified form to tradition name side, help Chinese medicine tradition name side and in preventing and curing diseases, play a role, name side is significant to the exploitation Chinese medicine; Method for preparing of the present invention is simple, and the effervescent tablet that makes is difficult for the moisture absorption, and outward appearance is not yielding, and disintegrate is fast, and dissolving is fast, has covered the bitterness of medicine, and mouthfeel is good, taking convenience, and the patient is easy to accept, and has increased patient's compliance, and has been convenient to store, transport, carry; The present invention adopts the method for lubricant such as Polyethylene Glycol parcel alkaline agent effectively to isolate contacting of alkaline agent and sour agent, has solved effervescent tablet and places the problem that is prone to inefficacy.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed description, said embodiment only is to explanation of the present invention rather than qualification.
Embodiment 1
1, the prescription of Herba Artemisiae Scopariae soup effervescent tablet (1000):
2, the extraction process of Herba Artemisiae Scopariae soup extractum is:
Get the Herba Artemisiae Scopariae medical material and add 8 times of quality water, decoct 1h behind the immersion 1h, add Fructus Gardeniae and rhubarb medicinal material again; Add 10 times of quality water of Herba Artemisiae Scopariae medical material, decoct 2h, leave standstill 12h; Filter, filtrating is concentrated into an amount of, adds ethanol after the cooling and makes and contain the alcohol amount and reach 80% (volume fraction); Filter after leaving standstill 12h, filtrating concentrates to such an extent that density is the Herba Artemisiae Scopariae soup extractum of 1.5g/ml, and Herba Artemisiae Scopariae: Fructus Gardeniae: the weight ratio of Radix Et Rhizoma Rhei is 70: 17: 23.
3, the preparation technology of Herba Artemisiae Scopariae soup effervescent tablet is:
(1) 40g Macrogol 4000 and 40g polyethylene glycol 6000 adding 150g sodium bicarbonate are stirred, cooling is pulverized, and crosses 80 mesh sieves, gets wrappage;
(2) tartaric acid and citric acid, lactose are crossed 80 mesh sieves respectively;
(3) with wrappage, 170g tartaric acid, 180g citric acid, 250g lactose, 8g steviosin mixing, add 160g Herba Artemisiae Scopariae soup extractum, granulate;
(4) granulation after drying, granulate, spray into 2g Fructus Citri Limoniae essence, drying, tabletting;
(5) through being up to the standards, packing promptly gets Herba Artemisiae Scopariae soup effervescent tablet.
Embodiment 2
1, the prescription of Herba Artemisiae Scopariae soup effervescent tablet (1000):
2, the extraction process of Herba Artemisiae Scopariae soup extractum is:
Get the Herba Artemisiae Scopariae medical material and add 10 times of quality water, decoct 2h behind the immersion 2h, add Fructus Gardeniae and rhubarb medicinal material again; Add 10 times of quality water of Herba Artemisiae Scopariae medical material, decoct 2h, leave standstill the 8h after-filtration; Filtrating is concentrated into an amount of, adds ethanol after the cooling and makes and contain the alcohol amount and reach 75% (volume fraction), filters after leaving standstill 8h; Filtrating concentrates to such an extent that density is the Herba Artemisiae Scopariae soup extractum of 1.3g/ml, and Herba Artemisiae Scopariae: Fructus Gardeniae: the weight ratio of Radix Et Rhizoma Rhei is 70: 17: 23.
3, the preparation technology of Herba Artemisiae Scopariae soup effervescent tablet is:
(1) 70g Macrogol 4000 adding 110g sodium carbonate and 100g sodium bicarbonate are stirred, cooling is pulverized, and crosses 120 mesh sieves, gets wrappage.
(2) adipic acid, lactose and sucrose are crossed 120 mesh sieves respectively;
(3) with wrappage, 280g adipic acid, 100g lactose and 150g sucrose, 2g disodium glycyrrhizinate mixing, add 180g Herba Artemisiae Scopariae soup extractum, granulate;
(4) granulation after drying, granulate, spray into 8g flavoring pineapple essence, drying, tabletting;
(5) through being up to the standards, packing promptly gets Herba Artemisiae Scopariae soup effervescent tablet.
Embodiment 3
1, the prescription of Herba Artemisiae Scopariae soup effervescent tablet (1000) composed of the following components:
2, the method for preparing of Herba Artemisiae Scopariae soup effervescent tablet may further comprise the steps:
(1) the 100g lubricant is added the 250g alkaline agent, stir, cooling is pulverized, and crosses 100 mesh sieves, gets wrappage; Said lubricant is a polyethylene glycol 6000, and alkaline agent is the mixture of sodium carbonate (110g), sodium bicarbonate (140g);
(2) sour agent, filler are crossed 100 mesh sieves respectively; Tartaric acid is selected in said sour agent, and filler is selected mannitol;
(3) with 200g acid agent, 230g filler, wrappage mixing, add 120g Herba Artemisiae Scopariae soup extractum, granulate;
(4) granulation after drying, granulate, spray into 50g aromatic, dry then, tabletting; Said aromatic is selected orange flavor;
(5) through being up to the standards, packing promptly gets Herba Artemisiae Scopariae soup effervescent tablet.
The method for distilling of said Herba Artemisiae Scopariae soup extractum decocts 1.5h for the water logging bubble back that the Herba Artemisiae Scopariae medical material is added 9 times of quality, and said soak time is 0.5h, adds Fructus Gardeniae and Radix Et Rhizoma Rhei then; The water that adds 10 times of quality of Herba Artemisiae Scopariae medical material again continues to decoct 1h and gets decocting liquid; Decocting liquid left standstill, filters the back concentrates, cooling, the time of leaving standstill is 6h, and the cooling back adds ethanol to be made and contain the alcohol amount and reach 70% (volume fraction); Leave standstill then, filtering and impurity removing; The time of leaving standstill is 6h, concentrates to such an extent that density is the Herba Artemisiae Scopariae soup extractum of 1.2g/ml after the remove impurity, and Herba Artemisiae Scopariae: Fructus Gardeniae: the weight ratio of Radix Et Rhizoma Rhei is 70: 17: 23.
Embodiment 4
1, the prescription of Herba Artemisiae Scopariae soup effervescent tablet (1000) composed of the following components:
2, the method for preparing of Herba Artemisiae Scopariae soup effervescent tablet may further comprise the steps:
(1) the 50g lubricant is added the 350g alkaline agent, stir, cooling is pulverized, and crosses 90 mesh sieves, gets wrappage; Said lubricant is the mixture of polyethylene glycol 6000 (20g), Macrogol 4000 (30g), and alkaline agent is a sodium carbonate;
(2) sour agent, filler are crossed 90 mesh sieves respectively; Citric acid is selected in said sour agent, and filler is selected sorbitol;
(3) with 400g acid agent, 190g filler, wrappage, 80g sweeting agent mixing, add 140g Herba Artemisiae Scopariae soup extractum, granulate; Said sweeting agent is selected the mixture of aspartame (50g), sucrose (30g);
(4) granulation after drying, granulate, dry then, tabletting;
(5) through being up to the standards, packing promptly gets Herba Artemisiae Scopariae soup effervescent tablet.
The method for distilling of said Herba Artemisiae Scopariae soup extractum decocts 1.5h for the water logging bubble back that the Herba Artemisiae Scopariae medical material is added 9 times of quality, and said soak time is 1.5h, adds Fructus Gardeniae and Radix Et Rhizoma Rhei then; The water that adds 10 times of quality of Herba Artemisiae Scopariae medical material again continues to decoct 1.5h and gets decocting liquid; Decocting liquid left standstill, filters the back concentrates, cooling, the time of leaving standstill is 10h, and the cooling back adds ethanol to be made and contain the alcohol amount and reach 70% (volume fraction); Leave standstill then, filtering and impurity removing; The time of leaving standstill is 10h, concentrates to such an extent that density is the Herba Artemisiae Scopariae soup extractum of 1.4g/ml after the remove impurity, and Herba Artemisiae Scopariae: Fructus Gardeniae: the weight ratio of Radix Et Rhizoma Rhei is 70: 17: 23.
The Herba Artemisiae Scopariae soup effervescent tablet sheet of above-mentioned method for preparing preparation heavily is 1g (per day for adults is taken Herba Artemisiae Scopariae soup effervescent tablet 3 times, each 3), and hardness is 5.5～6kg; Be 180～190s disintegration; Solution clarification after the disintegrate, deposit-free is residual, and pH is 5.0～5.5; Gas release is 8～9mL, meets the pharmacopeia regulation.
Claims (9)
1. Herba Artemisiae Scopariae soup effervescent tablet is characterized in that the prescription of this Herba Artemisiae Scopariae soup effervescent tablet is composed of the following components:
2. the method for preparing of Herba Artemisiae Scopariae soup effervescent tablet is characterized in that may further comprise the steps:
(1) 50～100g lubricant is added 150～350g alkaline agent, stir, cooling is pulverized, and crosses 80～120 mesh sieves, gets wrappage;
(2) sour agent, filler are crossed 80～120 mesh sieves respectively;
(3) with 200～400g acid agent, 190～250g filler, wrappage, 0～80g sweeting agent mixing, add 120～180g Herba Artemisiae Scopariae soup extractum, granulate;
(4) granulation after drying, granulate, spray into 0～50g aromatic, dry then, tabletting promptly gets Herba Artemisiae Scopariae soup effervescent tablet.
3. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 2 effervescent tablet; The method for distilling that it is characterized in that said Herba Artemisiae Scopariae soup extractum is: the water logging bubble back that Herba Artemisiae Scopariae is added 8-10 times of quality decocts 1～2h; Add Fructus Gardeniae and Radix Et Rhizoma Rhei then; The water that adds 10 times of quality of Herba Artemisiae Scopariae again continue to decoct 1～2h and gets decocting liquid, decocting liquid is left standstill, filters the back concentrates, cooling, and the cooling back adds ethanol to be made and contain the alcohol amount and reach 70～80%; Leave standstill then, filtering and impurity removing, concentrate to such an extent that density is the Herba Artemisiae Scopariae soup extractum of 1.2～1.5g/ml after the remove impurity.
4. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 3 effervescent tablet, it is characterized in that: said soak time is 0.5～2h, and the time of leaving standstill is 6～12h, Herba Artemisiae Scopariae: Fructus Gardeniae: the weight ratio of Radix Et Rhizoma Rhei is 70: 17: 23.
5. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 2 effervescent tablet, it is characterized in that: said lubricant is a kind of or mixture in polyethylene glycol 6000, the Macrogol 4000, and alkaline agent is a kind of or mixture in sodium carbonate or the sodium bicarbonate.
6. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 2 effervescent tablet; It is characterized in that: the mixture of one or more in said sour agent selection tartaric acid, citric acid or the adipic acid, the mixture of one or more in filler selection lactose, sucrose, mannitol or the sorbitol.
7. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 2 effervescent tablet, it is characterized in that: the mixture of one or more in said sweeting agent selection aspartame, sucrose, steviosin or the disodium glycyrrhizinate.
8. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 2 effervescent tablet, it is characterized in that: said aromatic is selected orange flavor, Fructus Citri Limoniae essence or flavoring pineapple essence.
9. according to the method for preparing of the said Herba Artemisiae Scopariae soup of claim 2 effervescent tablet; It is characterized in that: the Herba Artemisiae Scopariae soup effervescent tablet sheet of this method for preparing preparation heavily is 1g, and hardness is 5.5～6kg, and be 180～190s disintegration; Solution clarification after the disintegrate; Deposit-free is residual, and pH is 5.0～5.5, and gas release is 8～9mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110274574 CN102309579B (en) | 2011-09-16 | 2011-09-16 | Tarragon soup effervescent tablet and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110274574 CN102309579B (en) | 2011-09-16 | 2011-09-16 | Tarragon soup effervescent tablet and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102309579A true CN102309579A (en) | 2012-01-11 |
| CN102309579B CN102309579B (en) | 2013-07-24 |
Family
ID=45423387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110274574 Expired - Fee Related CN102309579B (en) | 2011-09-16 | 2011-09-16 | Tarragon soup effervescent tablet and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102309579B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090251A (en) * | 2019-06-03 | 2019-08-06 | 扬子江药业集团上海海尼药业有限公司 | A kind of preparation method of Artemisia capillaris piece |
| CN111358758A (en) * | 2020-03-15 | 2020-07-03 | 江西亿友药业有限公司 | Bromhexine hydrochloride dispersible tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008398A (en) * | 2009-09-04 | 2011-04-13 | 北京华素制药股份有限公司 | Iodine-contained effervescence composition and preparation method thereof |
-
2011
- 2011-09-16 CN CN 201110274574 patent/CN102309579B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008398A (en) * | 2009-09-04 | 2011-04-13 | 北京华素制药股份有限公司 | Iodine-contained effervescence composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李洪晓等: "茵陈蒿汤半仿生法实验研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090251A (en) * | 2019-06-03 | 2019-08-06 | 扬子江药业集团上海海尼药业有限公司 | A kind of preparation method of Artemisia capillaris piece |
| CN110090251B (en) * | 2019-06-03 | 2021-07-06 | 扬子江药业集团上海海尼药业有限公司 | Preparation method of artemisia capillaris tablet |
| CN111358758A (en) * | 2020-03-15 | 2020-07-03 | 江西亿友药业有限公司 | Bromhexine hydrochloride dispersible tablet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102309579B (en) | 2013-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102895432A (en) | Prescription and preparation method of rejoicing powder having new dosage form | |
| CN100560102C (en) | A kind of Chinese medicine composition for the treatment of cough due to lung-heat, hyperpyrexia | |
| CN102309579B (en) | Tarragon soup effervescent tablet and its preparation method | |
| CN102579598A (en) | Composition used for improving nutritional anaemia and preparation method thereof | |
| CN1943756B (en) | A Chinese traditional medicinal composition used for treatment of hypertension and its preparation method | |
| CN102389481A (en) | Chinese medical preparation for treating dysmenorrhea of women | |
| CN101590102A (en) | A kind of medicine for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof | |
| CN102641357B (en) | Medicament for treating hypertension and preparation method thereof | |
| CN105343581A (en) | Traditional Chinese medicine formula for dispelling the effects of alcohol | |
| CN101496858B (en) | Chinese medicinal composition for treating insomnia and preparation method thereof | |
| CN103005448A (en) | Health-care food composition for improving anoxia endurance and preparation method thereof | |
| CN103432386B (en) | A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof | |
| CN102178792A (en) | Shiqi exogenous Chinese medicinal buccal tablets | |
| CN105961992A (en) | Effervescent tablet beverage with efficacy of improving sleep | |
| CN102366487B (en) | Traditional Chinese medicine composition with functions of warming kidney and invigorating yang, and preparation method thereof | |
| CN1548039B (en) | Red sage dripping pill and its preparation | |
| CN104771444B (en) | A kind of bathing preparation and preparation method for the treatment of of insomnia patients | |
| CN101623359B (en) | Preparation method of drug composite with lung cancer resisting effect | |
| CN102233055B (en) | Pharmaceutical composition used for treating cerebral stroke, and preparation method thereof | |
| CN109498737B (en) | Pharmaceutical composition for treating metabolic diseases and preparation method and application thereof | |
| CN106947651A (en) | It is a kind of to be used for hypotensive, blood fat, grape wine of blood glucose and preparation method thereof | |
| CN101352488B (en) | Medicament composition for damp-heat type icterohepatitis and preparation method thereof | |
| CN106213511A (en) | A kind of can the Chinese medicine preparation and preparation method thereof of Antialcoholic liver-protecting | |
| CN107224562A (en) | A kind of composition with yang-tonifying function and preparation method thereof | |
| CN105456316A (en) | Plumeria rubra drop pill and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130724 Termination date: 20150916 |
|
| EXPY | Termination of patent right or utility model |