CN100560102C - A kind of Chinese medicine composition for the treatment of cough due to lung-heat, hyperpyrexia - Google Patents
A kind of Chinese medicine composition for the treatment of cough due to lung-heat, hyperpyrexia Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition, and this Chinese medicine composition is made up of Herba Artemisiae Annuae 900～1100 weight portions, Flos Lonicerae 500～700 weight portions, Fructus Gardeniae 300～450 weight portions, Radix Scutellariae 100～200 weight portions and Herba Houttuyniae 600～800 weight portions.The selection of the screening of this pharmaceutical composition crude drug and given dose proportion relation is the inventor through experimental summary, and the selection of above-mentioned raw materials medicine and specific proportion relation can influence the cough latent period of mice, obviously reduce the mouse cough number of times.The present invention discloses the preparation method of this Chinese medicine composition simultaneously and uses in the medicine of preparation treatment cough due to lung-heat, hyperpyrexia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of cough due to lung-heat, hyperpyrexia.
Background technology
According to statistics, the whole world has 2,000,000 people at least because heating causes death every year, and medical expense has had a strong impact on the healthy of people up to tens yuan.Therefore, controlling hyperpyrexia effectively, is the arduous and urgent task of medical worker.
The reason that causes hyperpyrexia has many, as viral infection, bacterial infection, mycoplasma infection, parasitic infection etc., and the hyperpyrexia that causes of virus and bacterial infection commonly wherein.Heating was a kind of defense reaction of body originally, it can accelerate metabolic processes, promotes antiviral growth and breeding, promotes leukocytosis, strengthen the function (cytophagous activity, antibody generation and liver detoxification ability etc.) of reticuloendothelial system, help the recovery of disease.Pattern of fever all has important value to diagnosis, judgement therapeutic effect and the prognosis of disease.Heating also can make physical demands on the other hand, causes headache, insomnia even convulsions.Excessive heat (more than 41 ℃) or lasting heating also can cause permanent brain damage and cause death dying.Therefore, it is necessary heating more than the moderate suitably being used antipyretic.
Doctor trained in Western medicine mainly is to use antipyretic analgesic (as non-steroidal drugs such as carbasalate calcium, aspirin lysine, ibuprofen, acetaminophen, naproxens) and antiviral antibacterials (as acyclovir, amantadine, virazole, penicillin etc. to the treatment of heating.) though it brings down a fever soon, toxic and side effects is big, mainly shows as nauseatingly, and gastrointestinal reaction such as vomiting, diarrhoea, stomachache and to hematoblastic influence, is had a liking for symptoms such as saliva, insomnia, erythra at also accidental dizziness.
The reason that causes cough has a lot: as antibacterial (streptococcus pneumoniae, streptococcus and staphylococcus etc.), infection, virus (adenovirus, influenza virus, parainfluenza virus etc.) infection, physical chemical factor, anaphylaxis etc.As protracted course of disease, with the passing of time can develop into diseases such as chronic bronchitis.
Doctor trained in Western medicine is used symptomatic treatment to the treatment of cough more, as using codeine, ammonium chloride, aminophylline etc.For merging bacterial infection etc., can use antibiotic therapy, and still not have effective Therapeutic Method at present for merging viral infection.
This shows that the Chinese medicine that cough due to lung-heat, hyperpyrexia can be effectively treated in exploitation is very necessary.
Summary of the invention
The object of the present invention is to provide a kind of is the pharmaceutical composition of feedstock production with the Chinese herbal medicine.Another object of the present invention is to provide this preparation of drug combination method and the application in the medicine of preparation treatment cough due to lung-heat, hyperpyrexia disease.
The crude drug of pharmaceutical composition of the present invention consists of:
Herba Artemisiae Annuae 900～1100 weight portion Flos Loniceraes 500～700 weight portions
Fructus Gardeniae 300～450 weight portion Radix Scutellariaes 100～200 weight portions
Herba Houttuyniae 600～800 weight portions.
The proportioning of aforementioned pharmaceutical compositions crude drug is:
Herba Artemisiae Annuae 950 weight portion Flos Loniceraes 530 weight portion Fructus Gardeniaes 335 weight portions
Radix Scutellariae 100 weight portion Herba Houttuyniae 700 weight portions.
The proportioning of aforementioned pharmaceutical compositions crude drug is:
Herba Artemisiae Annuae 1050 weight portion Flos Loniceraes 600 weight portion Fructus Gardeniaes 370 weight portions
Radix Scutellariae 200 weight portion Herba Houttuyniae 650 weight portions.
The proportioning of aforementioned pharmaceutical compositions crude drug is:
Herba Artemisiae Annuae 1000 weight portion Flos Loniceraes 550 weight portion Fructus Gardeniaes 355 weight portions
Radix Scutellariae 150 weight portion Herba Houttuyniae 750 weight portions.
Pharmaceutical composition crude drug of the present invention is made clinical or pharmaceutically acceptable dosage form according to a conventional method: tablet, soft capsule, capsule, slow releasing agent, granule, drop pill, oral liquid, freeze-dried powder or injection.
The preparation method of this drug combination preparation is as follows:
(1) adopt following either party's legal system to be equipped with Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder:
Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae are soaked, and volatile oil is collected in distillation, and is standby; Distillation back water liquid is concentrated into relative density and is 1.03～1.08, and is centrifugal, gets supernatant, filters, and filtrate concentrates, and drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder A;
Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae are soaked, and volatile oil is collected in distillation, and is standby; It is 1.03～1.08 that distillation back water liquid is concentrated into relative density, with hydrochloric acid adjust pH to 2～4, gets concentrated solution, with with the ethyl acetate extraction of concentrated solution equivalent 8～12 times, combining extraction liquid, reclaim under reduced pressure ethyl acetate, thick paste concentrates, and drying gets Flos Lonicerae, Herba Artemisiae Annuae, the dried cream B of Herba Houttuyniae;
Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae are soaked, and volatile oil is collected in distillation, and is standby; It is 1.03～1.08 that distillation back water liquid is concentrated into relative density, gets the medicinal liquid after concentrating, and by macroporous adsorptive resins, water and 60%～90% ethanol elution are collected ethanol elution respectively, concentrate, drying, Flos Lonicerae, Herba Artemisiae Annuae, the dried cream C of Herba Houttuyniae;
(2) get the Fructus Gardeniae coarse powder, concentrate with 60～90% alcohol refluxs, filtration, filtrate, filter adjust pH to 3.0～5.0, and it is 1.10～1.12 that filtrate is concentrated into relative density, and drying gets the Fructus Gardeniae dried cream powder;
(3) get Radix Scutellariae, decoct with water, after decoction liquor concentrates, with hydrochloric acid adjust pH to 1.0～2.0, leave standstill, centrifugal, get precipitation, the water that adds 2-3 times of precipitation capacity stirs evenly, with sodium hydroxide adjust pH to 7.0～8.0, the ethanol of adding and aqueous solution equivalent filters, get filtrate,, leave standstill with hydrochloric acid adjust pH to 1.0～2.0, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder;
(4) make saturated aqueous solution with the HP-beta-schardinger dextrin-or the beta-schardinger dextrin-of 10 times of volatilization oil masses, heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and puts coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound;
(5) get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, the dried cream A of Herba Houttuyniae, B or C, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound, add adjuvant or excipient, make tablet, soft capsule, capsule, slow releasing agent, granule, drop pill, oral liquid, freeze-dried powder or injection type.Weight portion/parts by volume is meant g/ml in the above-mentioned preparation method.
The selection of the screening of this pharmaceutical composition crude drug and given dose proportion relation is that the inventor is through experimental summary, the selection of above-mentioned raw materials medicine and specific proportion relation can influence the cough latent period of mice, obviously reduce the mouse cough number of times, below experimental example be used to further specify but be not limited to the present invention.
The test of experimental example antitussive action
Mice is divided into 5 groups at random, 10 every group, male and female half and half, be respectively the blank group, positive group and the high, medium and low dosage group of this drug combination preparation (tablet) (dosage is respectively 2.51g crude drug amount/kg, 7.54g crude drug amount/kg, and 22.62g crude drug amount/kg).Each organizes mice respectively by every 10g body weight 0.2ml/ gastric infusion.
Cough-relieving test: after the administration 1 hour, mice is placed in the inverted 500ml/ beaker, the cotton balls that will contain 0.3ml/ ammonia is put into beaker simultaneously, observe and write down the cough latent period of mice immediately and the number of times of coughing in 3 minutes, statistics is respectively organized mouse cough incubation period and cough number of times, with solvent control group ratio, t check between the row group.
The high, medium and low dosage group of this drug combination preparation all can obviously reduce mouse cough number of times (P＜0.01, P＜0.05), the same mouse cough number of times that obviously reduces of positive controls JIZHI TANGJIANG the results are shown in Table 1, proves that this drug combination preparation has antitussive action preferably.
This drug combination preparation of table 1 is to the antitussive action of mice
The following example all can be realized the effect of above-mentioned experimental example.
Embodiment 1:The preparation of tablet (unit: kilogram)
Herba Artemisiae Annuae 950 Flos Loniceraes 530 Fructus Gardeniaes 335 Radix Scutellariaes 100 Herba Houttuyniae 700,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 15 times of water gagings and soaked 3 hours, and heating decocts, distills 2 times, and each 2 hours, collect volatile oil simultaneously, standby.It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, with hydrochloric acid adjust pH to 2.5, get concentrated solution, with with the ethyl acetate extraction of concentrated solution equivalent 1 time, combining extraction liquid, the reclaim under reduced pressure ethyl acetate, it is 1.10～1.12 that thick paste is concentrated into 50 ℃ of relative densities, vacuum drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 8 times of amount 60% alcohol heating reflux 3 times, each 1 hour, merging filtrate filtered, concentrates, and with hydrochloric acid adjust pH to 4.0, heating, put coldly, filtered, and it is 1.10～1.12 that filtrate is concentrated into 50 ℃ of relative densities, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 8 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative proportion, with hydrochloric acid adjust pH to 1.0, leave standstill, centrifugal, get precipitation, the water that adds 3 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 7.5, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 1.5, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder.
HP-beta-schardinger dextrin-with 10 times of volatilization oil masses is made saturated aqueous solution, and heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and puts coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound.
Get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, the dried cream of Herba Houttuyniae, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound mixing add appropriate amount of auxiliary materials, granulate, compacting in flakes, every heavy 0.38g, the patient is oral, one time 3, three times on the one.
Embodiment 2:The preparation of granule dosage form (unit: kilogram)
Herba Artemisiae Annuae 1050 Flos Loniceraes 600 Fructus Gardeniaes 370 Radix Scutellariaes 200 Herba Houttuyniae 650,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 16 times of water gagings and soaked 3 hours, and heating decocts, distills 2 times, and each 2 hours, collect volatile oil simultaneously, standby; It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, and high speed centrifugation is got supernatant, the classification ultrafiltration, and ultrafiltrate concentrates, and drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 8 times of amount 75% alcohol heating reflux 3 times, each 1 hour, merging filtrate filtered, concentrates, and with hydrochloric acid adjust pH to 3.5, heating, put coldly, filtered, and filtrate concentrates, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 6 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative proportion, with hydrochloric acid adjust pH to 1.5, leave standstill, centrifugal, get precipitation, the water that adds 2 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 7.0, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 1.0, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder;
Beta-schardinger dextrin-with 10 times of volatilization oil masses is made saturated aqueous solution, and heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and puts coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound.
Get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, the dried cream of Herba Houttuyniae, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound mixing add appropriate amount of auxiliary materials, make granule, and warm water is taken after mixing it with water, a 1.3g, three times on the one.
Embodiment 3:The preparation of hard capsule (unit: kilogram)
Herba Artemisiae Annuae 1000 Flos Loniceraes 550 Fructus Gardeniaes 355 Radix Scutellariaes 150 Herba Houttuyniae,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 13 times of water gagings and soaked 3 hours, and heating decocts, distills 3 times, and each 2 hours, collect volatile oil, standby; It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, with hydrochloric acid adjust pH to 4, gets concentrated solution, with with the ethyl acetate extraction of concentrated solution equivalent 8 times, divide and get extract and merge the reclaim under reduced pressure ethyl acetate, the thick paste concentrating under reduced pressure, drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 6 times of amount 80% alcohol heating reflux 2 times, each 1 hour, merging filtrate filtered, concentrates, and with hydrochloric acid adjust pH to 3.0, heating, put coldly, filtered, and filtrate concentrates, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 6 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative density, with hydrochloric acid adjust pH to 1.3, leave standstill, centrifugal, get precipitation, the water that adds 2 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 7.6, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 1.4, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder.
HP-beta-schardinger dextrin-or beta-schardinger dextrin-with 10 times of volatilization oil masses are made saturated aqueous solution, and heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and put coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound.
Get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound mixing add appropriate amount of auxiliary materials, granulate, and incapsulate, granulate, every heavy 0.38g, the patient is oral, one time 3, three times on the one.
Embodiment 4:The preparation of drops (unit: kilogram)
Herba Artemisiae Annuae 900 Flos Loniceraes 500 Fructus Gardeniaes 315 Radix Scutellariaes 95 Herba Houttuyniae,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 18 times of water gagings and soaked 3 hours, and heating decocts, distills 3 times, and each 2 hours, collect volatile oil, standby; It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, gets the medicinal liquid after concentrating, and by macroporous adsorptive resins, water and 75% ethanol elution are collected ethanol elution respectively, concentrate, drying, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 7 times of amount 65% alcohol heating reflux 3 times, each 1 hour, merging filtrate filtered, concentrates, and with hydrochloric acid adjust pH to 4.5, heating, put coldly, filtered, and filtrate concentrates, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 7 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative proportion, with hydrochloric acid adjust pH to 2.0, leave standstill, centrifugal, get precipitation, the water that adds 2.5 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 7.35, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 2.0, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder.
HP-beta-schardinger dextrin-or beta-schardinger dextrin-with 10 times of volatilization oil masses are made saturated aqueous solution, and heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and put coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound.
Get PEG6000 and PEG4000 is an amount of, heating makes dissolving, gets above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder, behind Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and the volatile oil clathrate compound mixing, adds in the PEG mixture, stirs evenly, and drips and makes ball, and every ball contains content 0.06g.The patient is oral, one time 20, three times on the one.
Embodiment 5:The preparation of extractum sheet (unit: kilogram)
Herba Artemisiae Annuae 1100 Flos Loniceraes 600 Fructus Gardeniaes 400 Radix Scutellariaes 115 Herba Houttuyniae,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 14 times of water gagings and soaked 3 hours, and heating decocts, distills 2 times, and each 2 hours, collect volatile oil, standby; It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, with hydrochloric acid adjust pH to 3, gets concentrated solution, with with the ethyl acetate extraction of concentrated solution equivalent 9 times, divide and get extract and merge the reclaim under reduced pressure ethyl acetate, the thick paste concentrating under reduced pressure, drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 6 times of amount 70% alcohol heating reflux 3 times, each 1 hour, merging filtrate filtered, concentrates, and with hydrochloric acid adjust pH to 5.0, heating, put coldly, filtered, and filtrate concentrates, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 6 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative proportion, with hydrochloric acid adjust pH to 1.6, leave standstill, centrifugal, get precipitation, the water that adds 3 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 7.8, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 1.2, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder;
HP-beta-schardinger dextrin-or beta-schardinger dextrin-with 10 times of volatilization oil masses are made saturated aqueous solution, and heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and put coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound.
Get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound mixing are granulated, tabletting, every heavy 0.38g, the patient is oral, one time 3, three times on the one.
Embodiment 6:The preparation of controlled release capsule (unit: kilogram)
Herba Artemisiae Annuae 1000 Flos Loniceraes 550 Fructus Gardeniaes 355
Radix Scutellariae 150 Herba Houttuyniae 750,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 15 times of water gagings and soaked 3 hours, and heating decocts distillation 2 times, and each 2 hours, collect volatile oil, standby; It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, with hydrochloric acid adjust pH to 2, gets concentrated solution, with with the ethyl acetate extraction of concentrated solution equivalent 10 times, divide and get extract and merge the reclaim under reduced pressure ethyl acetate, the thick paste concentrating under reduced pressure, drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 5 times of amount 85% alcohol heating reflux 2 times, each 1 hour, merging filtrate filtered, concentrates, and with hydrochloric acid adjust pH to 4.3, heating, put coldly, filtered, and filtrate concentrates, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 6 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative proportion, with hydrochloric acid adjust pH to 1.8, leave standstill, centrifugal, get precipitation, the water that adds 2.5 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 8.0, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 1.7, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder.
HP-beta-schardinger dextrin-or beta-schardinger dextrin-with 10 times of volatilization oil masses are made saturated aqueous solution, and heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and put coldly, and cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound.
Get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound mixing add appropriate amount of auxiliary materials, granulate, and prepare controlled release granule with proper method, get granule, incapsulate, and granulate.Every contains content 0.4g.The patient is oral, one time 3, three times on the one.
Embodiment 7:The preparation of injection (unit: kilogram)
Herba Artemisiae Annuae 1000 Flos Loniceraes 600 Fructus Gardeniaes 480
Radix Scutellariae 150 Herba Houttuyniae 750,
The above five tastes, Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae add 15 times of water gagings and soaked 3 hours, and heating decocts, distills 2 times, and each 2 hours, collect volatile oil, standby; It is 1.03～1.08 that distillation back water liquid is evaporated to relative density, and high speed centrifugation is got supernatant, the classification ultrafiltration, and it is 1.10～1.12 that ultrafiltrate is evaporated to 50 ℃ of relative densities, vacuum drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder.
Get the Fructus Gardeniae coarse powder, with 6 times of amount 90% alcohol heating reflux 1 time, each 1 hour, merge medicinal liquid, filter, concentrate, with hydrochloric acid adjust pH to 4.0, heating, put coldly, filter, it is 1.10～1.12 that filtrate is concentrated into 50 ℃ of relative densities, vacuum drying, the Fructus Gardeniae dried cream powder.
Get Radix Scutellariae, add 8 times of water gagings and decoct 2 times, each 1 hour, it was 1.1 that decoction liquor is concentrated to relative proportion, with hydrochloric acid adjust pH to 1.0, leave standstill, centrifugal, get precipitation, the water that adds 2 times of precipitation capacities stirs evenly, and with sodium hydroxide adjust pH to 7.0, the dissolve with ethanol of adding and aqueous solution equivalent, filters, filtrate is used hydrochloric acid adjust pH to 2, and 80 ℃ are incubated 30 minutes, left standstill 24 hours, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder.
Get water for injection 800L, boil, get the Fructus Gardeniae dried cream powder, add in the water for injection, stirring and making dissolving, adjust pH is 3.5, and heating adds Flos Lonicerae, Herba Artemisiae Annuae, the dried cream of Herba Houttuyniae, stirs and makes dissolving, boils; Put coldly, cold preservation filters, and gets filtrate, and heating adds 0.8% needle-use activated carbon, boils, and filters, and puts cold; Adjust pH is 6.0～6.5, adds the Radix Scutellariae dried cream powder, stirs evenly, and takes out partly medicinal liquid, and heating adds tween 80, put coldly, add Flos Lonicerae, Herba Artemisiae Annuae and Herba Houttuyniae volatile oil Aromatic water, put coldly, join in the remaining medicinal liquid, stir, add injection water 1000L, microfiltration, embedding, sterilization, promptly.
Claims (9)
1, a kind of pharmaceutical composition for the treatment of cough due to lung-heat, hyperpyrexia is characterized in that the crude drug of said composition is made up of the following weight proportion raw material:
Herba Artemisiae Annuae 900～1100 weight portion Flos Loniceraes 500～700 weight portions
Fructus Gardeniae 300～450 weight portion Radix Scutellariaes 100～200 weight portions
Herba Houttuyniae 600～800 weight portions.
2, pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of said composition is made up of the following weight proportion raw material:
Herba Artemisiae Annuae 950 weight portion Flos Loniceraes 530 weight portion Fructus Gardeniaes 335 weight portions
Radix Scutellariae 100 weight portion Herba Houttuyniae 700 weight portions.
3, pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of said composition is made up of the following weight proportion raw material:
Herba Artemisiae Annuae 1050 weight portion Flos Loniceraes 600 weight portion Fructus Gardeniaes 370 weight portions
Radix Scutellariae 200 weight portion Herba Houttuyniae 650 weight portions.
4, pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of said composition is made up of the following weight proportion raw material:
Herba Artemisiae Annuae 1000 weight portion Flos Loniceraes 550 weight portion Fructus Gardeniaes 355 weight portions
Radix Scutellariae 150 weight portion Herba Houttuyniae 750 weight portions.
5,, it is characterized in that this pharmaceutical composition makes tablet, hard capsule, granule, drop pill or oral liquid as claim 1,2,3 or 4 described pharmaceutical compositions.
6, according to claim 1,2,3 or 4 described preparation of drug combination methods, it is characterized in that the preparation method of said composition may further comprise the steps:
(1) adopt following either party's legal system to be equipped with Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder:
Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae are soaked, and volatile oil is collected in distillation, and is standby; Distillation back water liquid is concentrated into relative density and is 1.03～1.08, and is centrifugal, gets supernatant, filters, and filtrate concentrates, and drying gets Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae dried cream powder A;
Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae are soaked, and volatile oil is collected in distillation, and is standby; It is 1.03～1.08 that distillation back water liquid is concentrated into relative density, with hydrochloric acid adjust pH to 2～4, gets concentrated solution, with with the ethyl acetate extraction of concentrated solution equivalent 8～12 times, combining extraction liquid, reclaim under reduced pressure ethyl acetate, thick paste concentrates, and drying gets Flos Lonicerae, Herba Artemisiae Annuae, the dried cream B of Herba Houttuyniae;
Flos Lonicerae, Herba Artemisiae Annuae, Herba Houttuyniae are soaked, and volatile oil is collected in distillation, and is standby; It is 1.03～1.08 that distillation back water liquid is concentrated into relative density, gets the medicinal liquid after concentrating, and by macroporous adsorptive resins, water and 60%～90% ethanol elution are collected ethanol elution respectively, concentrate, drying, Flos Lonicerae, Herba Artemisiae Annuae, the dried cream C of Herba Houttuyniae;
(2) get the Fructus Gardeniae coarse powder, concentrate with 60～90% alcohol refluxs, filtration, filtrate, filter adjust pH to 3.0～5.0, and it is 1.10～1.12 that filtrate is concentrated into relative density, and drying gets the Fructus Gardeniae dried cream powder;
(3) get Radix Scutellariae, decoct with water, after decoction liquor concentrates, with hydrochloric acid adjust pH to 1.0～2.0, leave standstill, centrifugal, get precipitation, the water that adds 2-3 times of precipitation capacity stirs evenly, with sodium hydroxide adjust pH to 7.0～8.0, the ethanol of adding and aqueous solution equivalent filters, get filtrate,, leave standstill with hydrochloric acid adjust pH to 1.0～2.0, centrifugal, get precipitation, wash with water respectively, ethanol is washed, and gets the precipitation drying after cleaning, and promptly gets the Radix Scutellariae dried cream powder;
(4) with 10 times of volatilization oil masses HP-β--cyclodextrin or beta-schardinger dextrin-are made saturated aqueous solution, heating adds Herba Artemisiae Annuae, Flos Lonicerae, Herba Houttuyniae volatile oil, stirs, and puts coldly, cold preservation filters, and gets precipitation, drying, volatile oil clathrate compound;
(5) get above-mentioned Flos Lonicerae, Herba Artemisiae Annuae, the dried cream A of Herba Houttuyniae, B or C, Fructus Gardeniae dried cream powder, Radix Scutellariae dried cream powder and volatile oil clathrate compound add adjuvant or excipient, make tablet, hard capsule, granule, drop pill or oral liquid.
7, preparation of drug combination method according to claim 6 is characterized in that the hard capsule in the preparation method of said composition is meant controlled release capsule.
8, as claim 1,2, the application of 3 or 4 described pharmaceutical compositions in the medicine of preparation treatment cough due to lung-heat, hyperpyrexia.
9, the application of pharmaceutical composition as claimed in claim 5 in the medicine of preparation treatment cough due to lung-heat, hyperpyrexia.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100658543A CN100560102C (en) | 2006-03-27 | 2006-03-27 | A kind of Chinese medicine composition for the treatment of cough due to lung-heat, hyperpyrexia |
| HK08102680A HK1108642A1 (en) | 2006-03-27 | 2008-03-07 | A chinese-medicinal composition for treating lung heat cough and high fever |
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| CNB2006100658543A CN100560102C (en) | 2006-03-27 | 2006-03-27 | A kind of Chinese medicine composition for the treatment of cough due to lung-heat, hyperpyrexia |
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| CN100560102C true CN100560102C (en) | 2009-11-18 |
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| HK (1) | HK1108642A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219193B (en) * | 2008-01-15 | 2012-05-23 | 陆小左 | Medicament for clearing heat, eliminating phlegm and relieving cough |
| CN104225236A (en) * | 2014-10-08 | 2014-12-24 | 山东理工大学 | Chinese herbal medicine composition for treating cough with lung heat in children |
| CN104225216A (en) * | 2014-10-08 | 2014-12-24 | 山东理工大学 | Chinese herbal preparation for treating children cough with lung heat |
| CN104258230A (en) * | 2014-10-08 | 2015-01-07 | 山东理工大学 | Chinese medicinal composition for treating pediatric lung heat cough |
| CN105687401A (en) * | 2014-11-25 | 2016-06-22 | 哈药集团中药二厂 | Traditional Chinese medicine composition comprising sweet wormwood, cape jasmine and honeysuckle and method for preparation of nasal cavity washing agent from traditional Chinese medicine composition |
| CN104873794A (en) * | 2015-06-23 | 2015-09-02 | 臧海阳 | Traditional Chinese medicine composition for treating cough with lung heat |
| CN105410277A (en) * | 2015-12-16 | 2016-03-23 | 济南昊泽环保科技有限公司 | Health-care tea with heat clearing and lung moistening functions as well as preparation method and application thereof |
| CN105327198A (en) * | 2015-12-16 | 2016-02-17 | 济南昊泽环保科技有限公司 | Heat-clearing and cough-relieving health care tea and preparation method and application thereof |
| CN110638944A (en) * | 2019-02-15 | 2020-01-03 | 广西本草坊保健品有限公司 | Chinese herbal medicine composition for conditioning children cough with lung heat and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569052A (en) * | 2003-07-24 | 2005-01-26 | 陈玉 | Medicine for killing SARS virus |
| CN1579351A (en) * | 2003-08-07 | 2005-02-16 | 天津医科大学 | Automatic-controlled laser operation machine for glaucoma filtration operation |
| CN1593595A (en) * | 2004-07-16 | 2005-03-16 | 南京中医药大学 | Lung clearing preparation for treating respiratory virus infection diseases |
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- 2006-03-27 CN CNB2006100658543A patent/CN100560102C/en active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569052A (en) * | 2003-07-24 | 2005-01-26 | 陈玉 | Medicine for killing SARS virus |
| CN1579351A (en) * | 2003-08-07 | 2005-02-16 | 天津医科大学 | Automatic-controlled laser operation machine for glaucoma filtration operation |
| CN1593595A (en) * | 2004-07-16 | 2005-03-16 | 南京中医药大学 | Lung clearing preparation for treating respiratory virus infection diseases |
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| CN101045106A (en) | 2007-10-03 |
| HK1108642A1 (en) | 2008-05-16 |
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