CN106213511A - A kind of can the Chinese medicine preparation and preparation method thereof of Antialcoholic liver-protecting - Google Patents
A kind of can the Chinese medicine preparation and preparation method thereof of Antialcoholic liver-protecting Download PDFInfo
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- CN106213511A CN106213511A CN201610596229.5A CN201610596229A CN106213511A CN 106213511 A CN106213511 A CN 106213511A CN 201610596229 A CN201610596229 A CN 201610596229A CN 106213511 A CN106213511 A CN 106213511A
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Classifications
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to field of health care food, there is provided a kind of can the Chinese medicine preparation and preparation method thereof of Antialcoholic liver-protecting, described can the Chinese medicine preparation of Antialcoholic liver-protecting be to be composed of the following raw materials by weight: Semen Trigonellae 12～24 parts, Radix Puerariae 15～25 parts, Mel 10～15 parts, Rhizoma Zingiberis 8～12 parts, Fructus Lycii 10～15 parts and glucose 20～25 parts.The Chinese medicine composition of the present invention has following effect: regulate immunologic function, increases the resistance against diseases of people's mechanism body.Acceleration of alcohol metabolism, protection hepatocyte, promote that hepatocyte is repaired and liver cell regeneration, it is possible to prevention fatty liver, alcoholic liver, play relieve the effect of alcohol, the functional effect of relieving alcoholic intoxication, and in good taste.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of can the Chinese medicine preparation of Antialcoholic liver-protecting and preparation side thereof
Method.
Background technology
In daily life and social communication, the situation of insobriety, drunk rear people is usually had often to have god
The symptoms such as intelligence is unclear, headache, regurgitation, severe patient also can alcoholism.Liver is inevitably damaged by long-term alcohol, mistake
Measure the infringement to human body of drinking and cause the great attention of people.The invention provides a kind of utilization with effects of relieving alcoholism and protecting liver
The health food that integration of edible and medicinal herbs Chinese medicine is made, solves this problem, promotes the healthy of people.On October 2nd, 2002
In invention disclosed patent application prospectus CN1371732A, disclose a kind of alcohol-decomposing beverage, its raw material consist of Radix Puerariae,
Concha Ostreae, Poria, Rhizoma Dioscoreae, Fructus Crataegi, Semen Lablab Album, Bulbus Lilii, Semen Phaseoli, Fructus Canarii, Semen Nelumbinis, Fructus Mori, Semen Coicis, Radix Glycyrrhizae, Fructus Amomi, Flos Chrysanthemi,
Fructus Momordicae, fresh Rhizoma Phragmitis, fresh Rhizoma Imperatae, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, Rhizoma Zingiberis, Fructus Jujubae, Mel.This prescription component is numerous, by 23 kinds of raw material groups
Becoming, this invention has the too much efficacy of a drug of component not concentrate the shortcoming affecting dispelling effects of alcohol.
Summary of the invention
It is an object of the present invention to provide a kind of Chinese medicine composition with Antialcoholic liver-protecting function.The another one of the present invention
Purpose there is provided the preparation method of this Chinese medicine composition.
In the present invention a kind of can the Chinese medicine preparation of Antialcoholic liver-protecting, be composed of the following raw materials by weight: Semen Trigonellae 12～
24 parts, Radix Puerariae 15～25 parts, Mel 10～15 parts, Rhizoma Zingiberis 8～12 parts, Fructus Lycii 10～15 parts and glucose 20～25 parts.
As preferably: in the present invention can the Chinese medicine preparation of Antialcoholic liver-protecting, be composed of the following raw materials by weight: Semen Trigonellae
18～24 parts, Radix Puerariae 20～25 parts, Mel 12～15 parts, Rhizoma Zingiberis 8～10 parts, Fructus Lycii 10～12 parts and glucose 20～25 parts.
As preferably: in the present invention can the Chinese medicine preparation of Antialcoholic liver-protecting, be composed of the following raw materials by weight: Semen Trigonellae
20 parts, Radix Puerariae 19 parts, Mel 14 parts, Rhizoma Zingiberis 10 parts, Fructus Lycii 12 parts and glucose 25 parts.
The present invention also provide for a kind of can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, comprise the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put in Chinese medicine extracting tank and grind
10min～15min, adds 200～250 weight portion pharmaceutical purpose pure water, and carries out being heated to boiling with 8～12 DEG C/min speed
Boiling, and keep 2～4h, with 40～100 mesh screen；Medicinal residues add 200～250 weight portion pharmaceutical purpose pure water, and with 20
～25 DEG C/min speed carries out being heated to boiling, and keep 1～2h, with 40～100 mesh screen, be then combined with secondary filtrate,
Proceed in vacuum concentration pot；
(2), by when in step (1), extraction acquisition filtrate is cooled to 60～70 DEG C, the glucose taking above-mentioned weight portion adds
Uniformly mix in filtrate, and the stirring 20～40min that remains a constant speed；Then gained mixed liquor is put at low pressure sterilizing cabinet sterilizing
Reason, then proceed to calorstat 20～25 DEG C of drying for standby；
(3), 20～25 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously,
Tinning final vacuum sealed cans, in Room-temperature low-pressure sterilization 30～60min.
The mechanism of action of the present composition is as follows:
Radix Puerariae: sweet in the mouth, pungent, property is put down, is returned spleen, stomach, lung, bladder warp.Expelling pathogenic factors from muscles for reducing heat；Deliver and examine；Promoting the production of body fluid to quench thirst；Yang invigorating is only
Rush down.Main fever caused by exogenous pathogens；Rigidity pain on the head and nape；Measles from the beginning of；Rash goes out the most smooth；Epidemic febrile disease is thirsty；Diabetes；Have loose bowels；Dysentery；Hypertension；Hat
Cardiopathia.Itself there is certain sober-up function: Radix Puerariae can solve alcohol toxicity, and can solution drain the most rapidly.Can relieve the effect of alcohol back
Brain bitterly rises, and the symptom such as blushes.Alleviate ethanol to absorb at gastric, protect gastric mucosa.
Semen Trigonellae: kidney-replenishing, dispelling cold and dampness.Control colic of cold type, abdomen side of body distension, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, sexual impotence.
Fructus Lycii: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quenches one's thirst, and blood deficiency is withered
Huang, blurred vision is failed to understand.
Rhizoma Zingiberis: Rhizoma Zingiberis methanol or ether extract have calmness, analgesia, antiinflammatory, preventing or arresting vomiting and the effect of of short duration raising blood pressure；Water carries
Take thing or volatile oil can be obviously prolonged Rat Experimental thrombus formation time；Rhizoma Zingiberis alcohol extraction thing and contained gingerol thereof and Rhizoma Zingiberis Recens are peppery
Ketenes has significant spiral shell and the anti-schistosome function of going out.Interior cold syndrome occur for YANG deficiency of the spleen and stomach, disease sees that food stagnation does not disappears, and vomits clear water,
Defecate dilute, abdomen cold type of pain, pale tongue with white fur, deep-thready pulse etc..Effectively treatment taste cold caused by deficiency, can't have dinner, and dizziness is told inverse.For lung cold,
The cough card stopped in phlegm retention.
Mel: invigorating middle warmer, moisturizes, pain relieving, removing toxic substances.Compendium of Material Medica cloud its " heat-clearing and toxic substances removing invigorating middle warmer moistens pain relieving also ", " book on Chinese herbal medicine
Through dredging " say: " SHIMI, its gas is cleer and peaceful, and its taste is pure sweet, the spirit QI and blood executed, deficiency and excess cold and heat, all diseases inside and outside negative and positive, deceives the most suitable ".
Wherein: Radix Puerariae is the most representational antialcoholic drugs in Chinese tradition Chinese herbal medicine；Simultaneously rich in many in Semen Trigonellae
Kind of fatty acid (mainly linoleic acid and Palmic acid, and have a small amount of oleic acid and linolenic acid), vitamin (mainly include vitamin
B1), trace element, oxidase, multiple proteins aminoacid, polypeptide etc., and have bitter temperature enter kidney channel, have warming the kidney to activate YANG it
Merit, can help Radix Puerariae Yiyang to join, and can produce concerted reaction effect with Radix Puerariae, effectively strengthen and support kidney hepatoprotective, and recklessly
Reed bar itself has the effects such as refreshing and detoxicating, diuresis be unobstructed, can jointly act on promotion facilitating alcohol metabolism and protecting liver with Radix Puerariae, therefore in the present invention
Radix Puerariae and Semen Trigonellae complement each other to form the principal agent composition (i.e. can reach main functional effect) of this invention product.
Compared with prior art, the Chinese medicine composition of the present invention has following effect:
(1), regulate immunologic function, increase the resistance against diseases of people's mechanism body.
Containing abundant vegetable polysaccharides, monosaccharide in the Chinese medicine composition of the present invention, wherein vegetable polysaccharides can improve human body machine
The nonspecific cellular immune function of body, and can promote body specific humoral immunity function, improves low imperial pathogenic bacteria, virus enters
The ability invaded.
(2), acceleration of alcohol metabolism, protection hepatocyte, promote hepatocyte repair and liver cell regeneration, it is possible to prevention fat
Liver, alcoholic liver, play relieve the effect of alcohol, the functional effect of relieving alcoholic intoxication.
In Semen Trigonellae rich in multiple fatty acid (mainly linoleic acid and Palmic acid, and have a small amount of oleic acid and linolenic acid),
Vitamin (mainly including vitamin B1), trace element, oxidase, multiple proteins aminoacid, polypeptide etc., it is possible to effectively
Strengthen nourishing and protecting liver, and refreshing and detoxicating, diuresis are unobstructed, can jointly act on promotion facilitating alcohol metabolism and protecting liver with Radix Puerariae.Lycium barbarum polysaccharide is to liver
Damage has repair, and its mechanism can promote protein synthesis and Detoxication by stoping the damage of endoplasmic reticulum, recover liver
The function of cell, and promote hepatocellular regeneration.
Daidzin in compositions Radix Puerariae, it can decompose acetaldehyde toxicity, suppress the intestines and stomach absorption to ethanol, promote in blood
The metabolism of ethanol and excretion.
The fructose not having containing a kind of most fruits in honey component, it can promote that the decomposition of ethanol absorbs, therefore
Be conducive to Quick sobering, and release the headache sense after drinking.Zoopery is (through using the experiment of typical white mice, the most in detail
See the specific embodiment in the present invention) confirm: take the present composition and can be obviously improved the drunk time of laboratory animal and sleep
The dormancy time.
And Mel can also provide energy to prepare for the metabolic activity of liver, and hepatic tissue can be stimulated to regenerate, and plays reparation and damages
The effect of wound.By detection alanine aminotransferase (ALT), aspartate amino transferase (AST), glutamyl transpeptidase
(γ-GT), the change of TOTAL BILE ACID TBA (TBA) can reflect animal livers degree of impairment.Zoopery is (through using typical little Bai
Mus is tested, and specifically refers to the specific embodiment in the present invention) confirm: Normal group is high with the present invention " described Chinese medicine composition "
I, in I, low I dosage group compare, the difference existed is notable substantially, when the present invention " described Chinese medicine composition " dosage is the highest
Time, corresponding ALT, AST, γ-GT, TBA activity (detection) value closer to the ICR white mice ALT in Normal group, AST,
γ-GT, TBA activity (detection) value.And Normal group is high by II with " comparison Chinese medicine composition ", in II, compared with low II dosage group
Relatively, there were significant differences.Experimental model group adds Chinese liquor each dosage group and compares with Chinese medicine composition of the present invention, and ALT, AST, γ-
GT, TBA activity substantially increases, and has highly significant difference.
Protective effect that i.e. in the present invention, liver is had by " described Chinese medicine composition " and effect, and compare " in comparison
Drug composition ", the present invention " described Chinese medicine composition " is significant to liver protection, and its effect is also more preferably, becomes apparent from
's.
(3) in good taste.
Detailed description of the invention
The present invention will be described in detail below.
Embodiment one:
A kind of can the Chinese medicine preparation of Antialcoholic liver-protecting, be composed of the following raw materials by weight: Semen Trigonellae 20 parts, Radix Puerariae 19 parts,
Mel 14 parts, Rhizoma Zingiberis 10 parts, Fructus Lycii 12 parts and glucose 25 parts.
Described can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, comprise the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put in Chinese medicine extracting tank and grind
15min, adds 200 weight portion pharmaceutical purpose pure water, and carries out being heated to boiling with 8～12 DEG C/min speed, and keep 4h, uses
100 mesh screen；Medicinal residues add 250 weight portion pharmaceutical purpose pure water, and carry out being heated to boiling with 25 DEG C/min speed, and
Keep 2h, use 100 mesh screen, be then combined with secondary filtrate, proceed in vacuum concentration pot；
(2), by when in step (1), extraction acquisition filtrate is cooled to 70 DEG C, the glucose taking above-mentioned weight portion adds filtrate
Interior uniformly mixing, and the stirring 20min that remains a constant speed；Then gained mixed liquor is put into low pressure sterilizing cabinet sterilization treatment, then turns
Enter 25 DEG C of drying for standby of calorstat；
(3), 25 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously, dress
Tank, bottling final vacuum sealed cans or envelope bottle (being i.e. prepared as convenient oral liquid), at Room-temperature low-pressure sterilization 30min.
Embodiment two:
A kind of can the Chinese medicine preparation of Antialcoholic liver-protecting, be to be composed of the following raw materials by weight: Semen Trigonellae 12 parts, Radix Puerariae 21
Part, Mel 15 parts, Rhizoma Zingiberis 12 parts, Fructus Lycii 15 parts and glucose 25 parts.
Described can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, comprise the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put in Chinese medicine extracting tank and grind
10min, adds 220 weight portion pharmaceutical purpose pure water, and carries out being heated to boiling with 10 DEG C/min speed, and keep 3h, with 80
Mesh screen；Medicinal residues add 220 weight portion pharmaceutical purpose pure water, and carry out being heated to boiling with 20 DEG C/min speed, and protect
Hold 1.5h, use 80 mesh screen, be then combined with secondary filtrate, proceed in vacuum concentration pot；
(2), by when in step (1), extraction acquisition filtrate is cooled to 65 DEG C, the glucose taking above-mentioned weight portion adds filtrate
Interior uniformly mixing, and the stirring 30min that remains a constant speed；Then gained mixed liquor is put into low pressure sterilizing cabinet sterilization treatment, then turns
Enter 20 DEG C of drying for standby of calorstat；
(3), 20 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously, dress
Tank, bottling final vacuum sealed cans or envelope bottle (being i.e. prepared as convenient oral liquid), at Room-temperature low-pressure sterilization 60min.
Embodiment three:
A kind of can the Chinese medicine preparation of Antialcoholic liver-protecting, be to be composed of the following raw materials by weight: Semen Trigonellae 24 parts, Radix Puerariae 15
Part, Mel 15 parts, Rhizoma Zingiberis 12 parts, Fructus Lycii 14 parts and glucose 20 parts.
Described can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, comprise the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put in Chinese medicine extracting tank and grind
13min, adds 200 weight portion pharmaceutical purpose pure water, and carries out being heated to boiling with 8 DEG C/min speed, and keep 3h, use 40 mesh
It is sieved through filter；Medicinal residues add 200 weight portion pharmaceutical purpose pure water, and carry out being heated to boiling with 20 DEG C/min speed, and keep
2h, uses 40 mesh screen, is then combined with secondary filtrate, proceeds in vacuum concentration pot；
(2), by when in step (1), extraction acquisition filtrate is cooled to 60 DEG C, the glucose taking above-mentioned weight portion adds filtrate
Interior uniformly mixing, and the stirring 30min that remains a constant speed；Then gained mixed liquor is put into low pressure sterilizing cabinet sterilization treatment, then turns
Enter 25 DEG C of drying for standby of calorstat；
(3), 25 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously, dress
Tank, bottling final vacuum sealed cans or envelope bottle (being i.e. prepared as convenient oral liquid), at Room-temperature low-pressure sterilization 60min.
Embodiment four:
A kind of can the Chinese medicine preparation of Antialcoholic liver-protecting, be to be composed of the following raw materials by weight: Semen Trigonellae 24 parts, Radix Puerariae 25
Part, Mel 10 parts, Rhizoma Zingiberis 8 parts, Fructus Lycii 10 parts and glucose 23 parts.
Described can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, comprise the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put in Chinese medicine extracting tank and grind
12min, adds 220 weight portion pharmaceutical purpose pure water, and carries out being heated to boiling with 10 DEG C/min speed, and keep 3h, with 60
Mesh screen；Medicinal residues add 220 weight portion pharmaceutical purpose pure water, and carry out being heated to boiling with 25 DEG C/min speed, and protect
Hold 1.5h, use 60 mesh screen, be then combined with secondary filtrate, proceed in vacuum concentration pot；
(2), by when in step (1), extraction acquisition filtrate is cooled to 65 DEG C, the glucose taking above-mentioned weight portion adds filtrate
Interior uniformly mixing, and the stirring 28min that remains a constant speed；Then gained mixed liquor is put into low pressure sterilizing cabinet sterilization treatment, then turns
Enter 22 DEG C of drying for standby of calorstat；
(3), 22 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously, dress
Tank, bottling final vacuum sealed cans or envelope bottle (being i.e. prepared as convenient oral liquid), at Room-temperature low-pressure sterilization 50min.
Embodiment five:
A kind of can the Chinese medicine preparation of Antialcoholic liver-protecting be to be composed of the following raw materials by weight: Semen Trigonellae 20 parts, Radix Puerariae 25 parts,
Mel 12 parts, Rhizoma Zingiberis 10 parts, Fructus Lycii 13 parts and glucose 20 parts.
Described can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, comprise the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put in Chinese medicine extracting tank and grind
11min, adds 210 weight portion pharmaceutical purpose pure water, and carries out being heated to boiling with 10 DEG C/min speed, and keep 3h, with 70
Mesh screen；Medicinal residues add 210 weight portion pharmaceutical purpose pure water, and carry out being heated to boiling with 25 DEG C/min speed, and protect
Hold 2h, use 70 mesh screen, be then combined with secondary filtrate, proceed in vacuum concentration pot；
(2), by when in step (1), extraction acquisition filtrate is cooled to 70 DEG C, the glucose taking above-mentioned weight portion adds filtrate
Interior uniformly mixing, and the stirring 30min that remains a constant speed；Then gained mixed liquor is put into low pressure sterilizing cabinet sterilization treatment, then turns
Enter 25 DEG C of drying for standby of calorstat；
(3), 25 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously, dress
Tank, bottling final vacuum sealed cans or envelope bottle (being i.e. prepared as convenient oral liquid), at Room-temperature low-pressure sterilization 40min.
First carry out toxicology test
One, acute toxicity test in mice (LD50)
1, material:
1.1, experiment material:
Sample is chocolate brown powder, is configured to each experimental group desired concn with medicinal water for injection.
1.2, animal:
The ICR white mice provided by children's hospital of Zhejiang University Experimental Animal Center, body weight 20-28g, male and female half and half.
2, method and result:
2.1, test method:
ICR white mice 80, body weight 25-32g, female, male half and half, use Horn ' s method, at random ICR white mice is divided into 4
Individual dosage group, with gavage twice, two minor ticks 4 hours on an empty stomach in the gavage amount 24 hours of 0.8ml/10g.b.w, observes one week,
Result see table.
2.2, result:
Test mice oral administration various dose (LD50 ＞ 51.4g/kg.b.w) Chinese medicine composition of the present invention, does not all see
Observe mice and have poisoning and other abnormal responses, show that Chinese medicine composition of the present invention is nontoxic material.
Relieve the effect of alcohol and liver protection effect test
1, experiment purpose:
Observe Chinese medicine composition of the present invention by animal experiment and (embodiment of the present invention uses this Chinese medicine composition
Oral liquid) ICR white mice is drunk after antialcoholism action and Chinese liquor is caused the protective effect of acute liver damage.
2, experiment material:
2.1, laboratory sample:
The oral liquid of Chinese medicine composition of the present invention, is three times a day according to recommended amounts, each 1 of oral liquid, and every is administered orally
The amount of liquid is that 1.0g/5ml/ props up, and is calculated as 0.033g/kg.b.w by 60kg adult, and the required each concentration of test all dilutes with pure water
Formulated.
2.2, test dose:
2.2.1, low dose group: 0.264g/kg.b.w, be equivalent to 8 times of recommended daily dosage.
2.2.2, middle dosage group: 0.528g/kg.b.w, be equivalent to 16 times of recommended daily dosage.
2.2.3, high dose group: 1.056g/kg.b.w, be equivalent to 32 times of recommended daily dosage.
2.3, laboratory animal:
Some of 6-8 week ICR white mice, the most healthy normal, body weight 25 ± 2g, male and female half and half.Cured by Zhejiang University child
Institute's Experimental Animal Center provides.
2.4, instrument and reagent:
2.4.1, instrument: Hitachi HITACHI 7060 type full automatic biochemical apparatus.
2.4.2, main agents: alanine aminotransferase (ALT), aspartate amino transferase (AST), glutamy
Transpeptidase (γ-GT), TOTAL BILE ACID TBA (TBA).Test kit is produced by Wuhan Sino-American Biotechnology Company.
2.4.3, experiment wine: cattle pen mountain strong, colourless liquor distilled from sorghum, 46% (V/V), Beijing along prosperous agricultural limited company produce,
Typically the most available commercially in supermarket.
3, experimental technique:
3.1, tested ICR white mice and the selection of beverage wine dosage: first arbitrarily choose 60 ICR white mice, be randomly divided into 3
Group, often group 20.Cattle pen mountain Erguotou wine, with distilled water diluting 5 times (1: 5 wine: distilled water), fills to the most respectively ICR white mice
Stomach 0.8ml/10g, 1.6ml/10g, 2.4ml/10g, the drunk number of ICR white mice in recording 20 minutes, result see table and (refers to down
Table one): drunk 11 of 0.8ml/10g group 20；1.6ml/10g organize 20 drunk 15；2.4ml/10g organize 20 whole liquor-saturated
Fall.Therefore select 2.4ml/10g as experiment dosage.
30 minutes drunk ordered series of numbers tables after ICR white mice beverage wine gavage
Table one
3.2, Chinese medicine composition of the present invention resists liquor-saturated experiment: separately taking ICR white mice 160, body weight 25 ± 2g, male and female are each
Half, it is randomly divided into 8 groups, often group 20, respectively Normal group (i.e. this group ICR white mice being filled equal-volume normal saline),
Experimental model group is (i.e. to this group ICR mice lavage experiment wine 2.4ml/10g；), " Chinese medicine composition " of the present invention is high
I, in I, low I 3 dosage groups and " comparison Chinese medicine composition " high by II, in II, low II 3 dosage groups.
Note explanation: i.e. described " comparison Chinese medicine composition " three groups (high by II, in II, low II 3 dosage groups): be to this
Chinese medicine composition (oral liquid) raw material described in invention eliminates " Semen Trigonellae " component, i.e. should " comparison Chinese drug-treated group in preparation
Compound " time do not add " Semen Trigonellae " component, other raw materials convert according to the weight portion of same ratio relation, prepared technique
Other uncorrelated factors such as method and hardware device are all to control unanimously；
Each experimental group gives after corresponding tested material gavage 60 minutes, more respectively gavage experiment with wine (1: 5 dilution)
2.4ml/10g, record ICR white mice drunk incubation period and the length of one's sleep.Result see table (referring to following table two), shows and compares
Group compares high dose group and middle dosage group has significant differences on drunk incubation period and the length of one's sleep.In of the present invention
Drug composition resists liquor-saturated experimental result:
Table two
3.3, the protective effect of the acute liver damage that Chinese liquor is caused by Chinese medicine composition of the present invention:
3.3.1, experiment wine: 46% (V/V) cattle pen mountain Erguotou wine distilled water diluting 100 times (1: 100).
3.3.2, Chinese medicine composition of the present invention dilution experiment wine be made into 10.0mg/ml, 20.0mg/ml,
50.0mg/ml, basic, normal, high dosage group.
3.3.3, the most separately take 160 ICR white mice, body weight 25 ± 2g, male and female half and half, and be randomly divided into 8 groups, often organize 20
Only, respectively Normal group (i.e. this group ICR white mice being filled equal-volume normal saline), experimental model group is (i.e. to this group ICR
Wine 2.4ml/10g is used in mice lavage experiment；), " Chinese medicine composition " of the present invention high by I, in I, low I 3 dosage groups and
" comparison Chinese medicine composition " high by II, in II, low II 3 dosage groups.(note illustrating: i.e. described " comparison Chinese medicine composition " three groups
(high by II, in II, low II 3 dosage groups): be to eliminate in heretofore described Chinese medicine composition (oral liquid) raw material
" Semen Trigonellae " component, i.e. should not add " Semen Trigonellae " component time " comparison Chinese medicine composition " in preparation, and other raw materials are according to identical
The weight portion of proportionate relationship converts, and other uncorrelated factors such as prepared process and hardware device are all control one
Cause.)
Specifically it is grouped as follows:
1. Normal group, fills equal-volume normal saline；
2. experimental model group, wine 2.4ml/10g is used in gavage experiment；
The highest I dosage group (50mg/ml)；
4. I dosage group (20mg/ml) in；
The lowest I dosage group (10mg/ml).
The highest II dosage group (50mg/ml)；
7. II dosage group (20mg/ml) in；
The lowest II dosage group (10mg/ml).
Once a day, every ICR white mice filling 2.5ml, continuous 12 days.12nd day, weighing and see table, routine takes blood,
Measure Serum ALT, AST, γ-GT, TBA activity, see table.
The Chinese medicine composition of the present invention impact (seeing below table three) on alcoholic liver injury ICR white mice body weight
Table three
The Chinese medicine composition of the present invention impact on ICR white mice acute alcohol-induced hepatic injury
Table four
3.4, result:
3.4.1, from above-mentioned table three, experimental model group body weight after continuous 12 days fill Chinese liquor substantially reduces, and normally
Matched group weight ratio relatively, its difference highly significant.
By the high I dosage group body weight of the present invention " described Chinese medicine composition " almost without rising or declining, i.e. body weight keeps
Plateau, illustrates the ICR white mice health normal table in the high I dosage group of this Chinese medicine composition.
Compare in described Chinese medicine composition I, low I dosage group ICR white mice body weight has declined, but lesser extent, front and back
Comparison, there was no significant difference.
And " comparison Chinese medicine composition " high by II, in II, this ICR white mice body weight of three groups of low II dosage group the most under
Fall, its decline degree compare the present invention " described Chinese medicine composition " high by I, in I, low I dosage group ICR white mice weight loss ground big
Some, but compare the ICR white mice body weight of experimental model group, and it is relatively lighter that it declines degree, and after cross-reference, significance is poor
Different smaller.
From experiment before and after ICR white mice body weight situation of change can tentative confirmation, liver is had damage by Chinese liquor, but this
Invent described Chinese medicine composition and add Chinese liquor each experimental group ICR Mice anharmonic ratio experimental model group ICR white mice weight loss relatively
Little, reach the present invention " described Chinese medicine composition " of doses (i.e. high dose) to adding Chinese liquor each experimental group ICR Mice
What almost without affect on heavy prescription face.Not only illustrate that Chinese medicine composition of the present invention has certain protective effect to liver,
And than " comparison Chinese medicine composition " to liver protection more preferably, effect becomes apparent from.
3.4.2, from above-mentioned table four, experimental model group compares with Normal group, and ALT, AST, γ-GT, TBA live
Property substantially increase, have highly significant difference, prompting has hepatocyte injury.
Wherein: use the whether present invention " described Chinese medicine composition " high by I, in I, low I dosage group, or " comparison Chinese medicine
Compositions " high by II, in II, low II dosage group, dosage height (i.e. concentration) is different, the ICR white mice that each group is corresponding
ALT, AST, γ-GT, TBA activity have more significant difference.
And: the present invention " described Chinese medicine composition " is high by I, in I, low I dosage group high with " compareing Chinese medicine composition " by II, in
II, low II dosage group compares, and there were significant differences.
Normal group is high by I with the present invention " described Chinese medicine composition ", in I, compared with low I dosage group, the difference existed
Notable obvious, when the present invention " described Chinese medicine composition " dosage is the highest time, corresponding ALT, AST, γ-GT, TBA activity
(detection) value is closer to ICR white mice ALT, AST, γ-GT, TBA activity (detection) value in Normal group.
And Normal group is high by II with " comparison Chinese medicine composition ", in II, compared with low II dosage group, there were significant differences.
Experimental model group adds Chinese liquor each dosage group and compares with Chinese medicine composition of the present invention, ALT, AST, γ-GT, TBA
Activity substantially increases, and has highly significant difference.
Can not only illustrate that the protection that liver is had by the present invention " described Chinese medicine composition " is made according to above-mentioned experiment conclusion
With and effect, and compare " comparison Chinese medicine composition ", the present invention " described Chinese medicine composition " is notable to liver protection
, its effect is also more preferably, more obviously.
Claims (4)
1. one kind can the Chinese medicine preparation of Antialcoholic liver-protecting, it is characterised in that be composed of the following raw materials by weight: Semen Trigonellae 12～24
Part, Radix Puerariae 15～25 parts, Mel 10～15 parts, Rhizoma Zingiberis 8～12 parts, Fructus Lycii 10～15 parts and glucose 20～25 parts.
2. can the Chinese medicine preparation of Antialcoholic liver-protecting according to a kind of described in claim 1, it is characterised in that by following weight portion
Raw material form: Semen Trigonellae 18～24 parts, Radix Puerariae 20～25 parts, Mel 12～15 parts, Rhizoma Zingiberis 8～10 parts, Fructus Lycii 10～12 parts and
Glucose 20～25 parts.
3. can the Chinese medicine preparation of Antialcoholic liver-protecting according to a kind of described in claim 2, it is characterised in that by following weight portion
Raw material forms: Semen Trigonellae 20 parts, Radix Puerariae 19 parts, Mel 14 parts, Rhizoma Zingiberis 10 parts, Fructus Lycii 12 parts and glucose 25 parts.
4. according in claims 1 to 3 arbitrary described a kind of can the preparation method of Chinese medicine preparation of Antialcoholic liver-protecting, its feature
It is, comprises the steps:
(1), weigh the Semen Trigonellae of the above weight portion, Radix Puerariae, Rhizoma Zingiberis and Fructus Lycii, put into grinding 10min in Chinese medicine extracting tank
～15min, add 200～250 weight portion pharmaceutical purpose pure water, and carry out being heated to boiling with 8～12 DEG C/min speed, and protect
Hold 2～4h, with 40～100 mesh screen；Medicinal residues add 200～250 weight portion pharmaceutical purpose pure water, and with 20～25 DEG C/
Min speed carries out being heated to boiling, and keeps 1～2h, with 40～100 mesh screen, is then combined with secondary filtrate, proceeds to vacuum
In concentration tank；
(2), by when in step (1), extraction acquisition filtrate is cooled to 60～70 DEG C, the glucose taking above-mentioned weight portion adds filtrate
Interior uniformly mixing, and the stirring 20～40min that remains a constant speed；Then gained mixed liquor is put into low pressure sterilizing cabinet sterilization treatment,
Proceed to calorstat again 20～25 DEG C of drying for standby；
(3), 20～25 DEG C of mixed liquors taking in step (2) calorstat add the Mel of above-mentioned weight portions, after mix homogeneously, tinning
Final vacuum sealed cans, in Room-temperature low-pressure sterilization 30～60min.
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