CN101274042A - Medicament composition for curing hyperlipemia and method of preparing the same - Google Patents
Medicament composition for curing hyperlipemia and method of preparing the same Download PDFInfo
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- CN101274042A CN101274042A CNA2008101116315A CN200810111631A CN101274042A CN 101274042 A CN101274042 A CN 101274042A CN A2008101116315 A CNA2008101116315 A CN A2008101116315A CN 200810111631 A CN200810111631 A CN 200810111631A CN 101274042 A CN101274042 A CN 101274042A
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Abstract
The invention discloses a pharmaceutical composition which treats hyperlipidemia and a preparation method thereof. The pharmaceutical composition is prepared from the following crude drugs according to the following weight proportions: gynostemma pentaphyllum: 5-40, cassia seed: 5-30, ilexlutifolia thumb: 5-30, panax notoginseng: 5-20, ginseng: 5-20, Chinese rhubarb: 5-30, hawthorn: 5-30, chuanxiong rhizome: 5-30, medlar: 5-30, kelp: 5-30, fleece-flower root: 5-20, lotus leaves: 5-20, rhizoma alismatis: 5-20 and radix bupleuri: 5-20. The pharmaceutical composition has the functions of clearing heat, activating blood, dissolving stasis and reducing turbidity and is applied to treating hyperlipidemia caused by blood-stasis with symptoms of obesity, dizziness, chest distress, acroparalysis, palpitation and insomnia.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly relate to a kind of pharmaceutical composition for the treatment of hyperlipemia and preparation method thereof, belong to the novel technique field.
Background technology
Hyperlipemia is that to increase with blood plasma lipide concentration be the disease of main clinical manifestation, mainly shows as lipids contents such as cholesterol, triglyceride, low density lipoprotein, LDL, high density lipoprotein and is higher than normal value.
In recent years, along with improving constantly of human living standard, hyperlipidemia incidence constantly rises, and presents tangible rejuvenation trend, the absorption of a large amount of high lipid foods, momental continuous minimizing are the main causes that causes the hyperlipemia incidence rate constantly to rise.Massive epidemiology and clinical research result confirm, hyperlipemia is the important risk factor of cardiovascular and cerebrovascular disease, be to cause the continuous one of the main reasons that rises of cardiovascular and cerebrovascular disease sickness rate in recent years, the not only actuatable pulse atherosclerosis of hyperlipemia, and cardiovascular disease such as easy complicated hypertension, diabetes, human health and life security in serious threat.
At present, the treatment of hyperlipemia comprises chemicals, Chinese medicine etc. based on Drug therapy, chemicals such as Statins, fibrate, though effectively blood fat reducing need be taken for a long time, all has certain side effect, Chinese medicine is aspect the hyperlipemia treatment, have dialectical executing and control, whole conditioning, the prevention for the treatment of both the principal and secondary aspects of a disease and treatment advantage, therefore, Chinese medicine has the prospect of marketing preferably aspect the hyperlipemia treatment.
Summary of the invention
One of the object of the invention is to provide a kind of pharmaceutical composition for the treatment of hyperlipemia, and this product has heat clearing away, invigorate blood circulation, and blood stasis dispelling, the effect of the turbid descending is used for the hyperlipemia of turbid stasis of blood mutual resistance, and disease is seen numb heavy, the cardiopalmus of obesity, dizziness, uncomfortable in chest, limb, insomnia.
Two of the object of the invention is to provide this preparation of drug combination method.
Hyperlipemia belongs to the turbid category that waits of traditional Chinese medical science expectorant, and Chinese traditional treatment is a basis with blood stasis dispelling, the turbid descending.
The present invention is on the basis of hyperlipemia clinical treatment experience for many years, selectedly have heat clearing away, invigorate blood circulation, the Chinese crude drug of blood stasis dispelling, the turbid descending effect, form through the science compatibility, clinical effectiveness is definite, for enlarging the clinical application range of this medicine, the present invention is on the modern study basis, in conjunction with modern preparation technique, through extract, concentrate, processing technique such as drying, be processed into the pharmaceutical preparation that is suitable for wide clinical application, it is simple to have production technology, steady quality, safe and effective, characteristics such as have no side effect.
The pharmaceutical composition of treatment hyperlipemia provided by the invention is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli 5～40 weight portion Semen Cassiaes 5～30 weight portions
Folium Ilicis 5～30 weight portion Radix Notoginseng 5～20 weight portions
Radix Ginseng 5～20 weight portion Radix Et Rhizoma Rhei 5～30 weight portions
Fructus Crataegi 5～30 weight portion Rhizoma Chuanxiongs 5～30 weight portions
Fructus Lycii 5～30 weight portion Thallus Laminariae (Thallus Eckloniae)s 5～30 weight portions
Radix Polygoni Multiflori 5～20 weight portion Folium Nelumbinis 5～20 weight portions
Rhizoma Alismatis 5～20 weight portion Radix Bupleuri 5～20 weight portions
Further, the pharmaceutical composition of treatment hyperlipemia provided by the invention can be adopted as following raw materials by weight proportions especially and make:
Herb Gynostemmae Pentaphylli 20 weight portion Semen Cassiaes 15 weight portions
Folium Ilicis 10 weight portion Radix Notoginseng 10 weight portions
Radix Ginseng 10 weight portion Radix Et Rhizoma Rhei 15 weight portions
Fructus Crataegi 10 weight portion Rhizoma Chuanxiongs 10 weight portions
Fructus Lycii 10 weight portion Thallus Laminariae (Thallus Eckloniae)s 10 weight portions
Radix Polygoni Multiflori 10 weight portion Folium Nelumbinis 10 weight portions
Rhizoma Alismatis 10 weight portion Radix Bupleuri 10 weight portions
The present invention adopts modern preparation technique, through preparation process such as extracting, concentrate, can be processed into acceptable tablet, capsule, granule, the arbitrary dosage form of concentrated pill clinically.
The present invention realizes by following preparation method:
(1) get Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, be ground into coarse powder, with 6～10 times of amount 50%～95% alcohol reflux 2～4 times, each 1～3 hour, extract pure liquid and filter, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.35 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Ilicis, Radix Et Rhizoma Rhei, Fructus Crataegi, Fructus Lycii, Thallus Laminariae (Thallus Eckloniae), Radix Polygoni Multiflori, Folium Nelumbinis, Rhizoma Alismatis, Radix Bupleuri, be ground into coarse powder, add above-mentioned medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, and merged to filter, be concentrated into relative density and be 1.10～1.35 clear paste, standby;
(3) get above-mentioned clear paste, mix homogeneously, formulation method adds suitable pharmaceutical adjunct routinely, molding, packing, check, promptly.
The specific embodiment
Embodiment 1
Prescription is formed:
Herb Gynostemmae Pentaphylli 100g Semen Cassiae 75g Folium Ilicis 50g Radix Notoginseng 50g
Radix Ginseng 50g Radix Et Rhizoma Rhei 75g Fructus Crataegi 50g Rhizoma Chuanxiong 50g
Fructus Lycii 50g Thallus Laminariae (Thallus Eckloniae) 50g Radix Polygoni Multiflori 50g Folium Nelumbinis 50g
Rhizoma Alismatis 50g Radix Bupleuri 50g starch 150g
Make 1000 altogether
Preparation method:
(1) gets Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 75% alcohol reflux 2 hours; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.25 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Ilicis, Radix Et Rhizoma Rhei, Fructus Crataegi, Fructus Lycii, Thallus Laminariae (Thallus Eckloniae), Radix Polygoni Multiflori, Folium Nelumbinis, Rhizoma Alismatis, Radix Bupleuri, be ground into coarse powder, add above-mentioned medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merge to filter, be concentrated into relative density and be 1.25 clear paste, standby;
(3) get above-mentioned clear paste, mix homogeneously adds starch, and mixing is granulated, drying, and granulate gets granule, and is standby;
(4) get granule, add 0.4% magnesium stearate, mix homogeneously, tabletting, the bag film-coat, packing, check, promptly.
Embodiment 2
Prescription is formed:
Herb Gynostemmae Pentaphylli 100g Semen Cassiae 75g Folium Ilicis 50g Radix Notoginseng 50g
Radix Ginseng 50g Radix Et Rhizoma Rhei 75g Fructus Crataegi 50g Rhizoma Chuanxiong 50g
Fructus Lycii 50g Thallus Laminariae (Thallus Eckloniae) 50g Radix Polygoni Multiflori 50g Folium Nelumbinis 50g
Rhizoma Alismatis 50g Radix Bupleuri 50g dextrin 80g
Make 1000 altogether
Preparation method:
(1) gets Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 75% alcohol reflux 2 hours; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.30 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Ilicis, Radix Et Rhizoma Rhei, Fructus Crataegi, Fructus Lycii, Thallus Laminariae (Thallus Eckloniae), Radix Polygoni Multiflori, Folium Nelumbinis, Rhizoma Alismatis, Radix Bupleuri, be ground into coarse powder, add above-mentioned medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merge to filter, be concentrated into relative density and be 1.30 clear paste, standby;
(3) get above-mentioned clear paste, mix homogeneously adds dextrin, mix homogeneously, and vacuum drying is ground into fine powder, crosses 100 mesh sieves, gets extract powder, and is standby;
(4) get extract powder, add 0.6% magnesium stearate, mix homogeneously, encapsulated, packing, check, promptly.
Embodiment 3
Prescription is formed:
Herb Gynostemmae Pentaphylli 100g Semen Cassiae 75g Folium Ilicis 50g Radix Notoginseng 50g
Radix Ginseng 50g Radix Et Rhizoma Rhei 75g Fructus Crataegi 50g Rhizoma Chuanxiong 50g
Fructus Lycii 50g Thallus Laminariae (Thallus Eckloniae) 50g Radix Polygoni Multiflori 50g Folium Nelumbinis 50g
Rhizoma Alismatis 50g Radix Bupleuri 50g Mel 50g sucrose 800g
Make 1000g altogether
Preparation method:
(1) gets Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount 75% alcohol reflux 2 hours; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours, extract pure liquid and filter; Medicinal residues add 10 times of amount 75% alcohol reflux 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.20 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Ilicis, Radix Et Rhizoma Rhei, Fructus Crataegi, Fructus Lycii, Thallus Laminariae (Thallus Eckloniae), Radix Polygoni Multiflori, Folium Nelumbinis, Rhizoma Alismatis, Radix Bupleuri, be ground into coarse powder, add above-mentioned medicinal residues, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merge to filter, be concentrated into relative density and be 1.20 clear paste, standby;
(3) get above-mentioned clear paste, mix homogeneously adds Mel, sucrose, and mix homogeneously is granulated, drying, and granulate gets granule, and is standby;
(4) get granule, packing, packing, check, promptly.
Claims (4)
1, the pharmaceutical composition of treatment hyperlipemia is characterized in that said composition is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli 5～40 weight portion Semen Cassiaes 5～30 weight portions
Folium Ilicis 5～30 weight portion Radix Notoginseng 5～20 weight portions
Radix Ginseng 5～20 weight portion Radix Et Rhizoma Rhei 5～30 weight portions
Fructus Crataegi 5～30 weight portion Rhizoma Chuanxiongs 5～30 weight portions
Fructus Lycii 5～30 weight portion Thallus Laminariae (Thallus Eckloniae)s 5～30 weight portions
Radix Polygoni Multiflori 5～20 weight portion Folium Nelumbinis 5～20 weight portions
Rhizoma Alismatis 5～20 weight portion Radix Bupleuri 5～20 weight portions
2, the pharmaceutical composition of treatment hyperlipemia as claimed in claim 1 is characterized in that said composition is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli 20 weight portion Semen Cassiaes 15 weight portions
Folium Ilicis 10 weight portion Radix Notoginseng 10 weight portions
Radix Ginseng 10 weight portion Radix Et Rhizoma Rhei 15 weight portions
Fructus Crataegi 10 weight portion Rhizoma Chuanxiongs 10 weight portions
Fructus Lycii 10 weight portion Thallus Laminariae (Thallus Eckloniae)s 10 weight portions
Radix Polygoni Multiflori 10 weight portion Folium Nelumbinis 10 weight portions
Rhizoma Alismatis 10 weight portion Radix Bupleuri 10 weight portions
3, the pharmaceutical composition of treatment hyperlipemia as claimed in claim 1 or 2 can be processed into acceptable tablet, capsule, granule, the arbitrary dosage form of concentrated pill clinically.
4, the preparation of drug combination method of treatment hyperlipemia as claimed in claim 1 or 2 is as follows:
(1) get Radix Notoginseng, Radix Ginseng, Rhizoma Chuanxiong, be ground into coarse powder, with 6～10 times of amount 50%～95% alcohol reflux 2～4 times, each 1～3 hour, extract pure liquid and filter, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.35 clear paste, standby; Medicinal residues are waved diffusing ethanol, and are standby;
(2) get Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Ilicis, Radix Et Rhizoma Rhei, Fructus Crataegi, Fructus Lycii, Thallus Laminariae (Thallus Eckloniae), Radix Polygoni Multiflori, Folium Nelumbinis, Rhizoma Alismatis, Radix Bupleuri, be ground into coarse powder, add above-mentioned medicinal residues, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filtered, and merged to filter, be concentrated into relative density and be 1.10～1.35 clear paste, standby;
(3) get above-mentioned clear paste, mix homogeneously, formulation method adds suitable pharmaceutical adjunct routinely, molding, packing, check, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101116315A CN101274042A (en) | 2008-05-15 | 2008-05-15 | Medicament composition for curing hyperlipemia and method of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101116315A CN101274042A (en) | 2008-05-15 | 2008-05-15 | Medicament composition for curing hyperlipemia and method of preparing the same |
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| CN101274042A true CN101274042A (en) | 2008-10-01 |
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| CNA2008101116315A Pending CN101274042A (en) | 2008-05-15 | 2008-05-15 | Medicament composition for curing hyperlipemia and method of preparing the same |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000299A (en) * | 2010-11-09 | 2011-04-06 | 赵晓红 | Medicine for treating hyperlipidaemia |
| CN102132870A (en) * | 2011-02-25 | 2011-07-27 | 中国热带农业科学院热带生物技术研究所 | Diet health-care product and preparation method thereof |
| CN102293838A (en) * | 2011-08-29 | 2011-12-28 | 湖北康进药业有限责任公司 | Traditional Chinese medicine composition for reducing blood fat, and preparation method thereof |
| CN102423413A (en) * | 2012-01-04 | 2012-04-25 | 陈伯明 | Medicament for treating hyperlipemia and fatty liver and preventing atherosclerosis as well as applications thereof |
| CN102846879A (en) * | 2012-09-29 | 2013-01-02 | 广西梧州制药（集团）股份有限公司 | Composition for depressing blood fat |
| CN103861027A (en) * | 2012-12-18 | 2014-06-18 | 李玲玲 | Medicated bath prescription mainly treating hyperlipidemia and preparation method thereof |
| CN104138529A (en) * | 2013-08-09 | 2014-11-12 | 田艺儿 | Traditional Chinese medicine preparation capable of reducing blood lipid and preparation method of Traditional Chinese medicine preparation |
| CN107173806A (en) * | 2017-06-09 | 2017-09-19 | 耿成好 | A kind of health food and preparation method with blood fat reducing function |
| CN108404062A (en) * | 2018-06-11 | 2018-08-17 | 北京中医药大学 | Treat the Chinese medicine composition and its preparation method and application of hyperlipidemia |
| CN115462525A (en) * | 2022-09-19 | 2022-12-13 | 药侠谷(北京)医药文化有限公司 | Blood fat regulating composition and preparation method and application thereof |
-
2008
- 2008-05-15 CN CNA2008101116315A patent/CN101274042A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000299A (en) * | 2010-11-09 | 2011-04-06 | 赵晓红 | Medicine for treating hyperlipidaemia |
| CN102132870A (en) * | 2011-02-25 | 2011-07-27 | 中国热带农业科学院热带生物技术研究所 | Diet health-care product and preparation method thereof |
| CN102132870B (en) * | 2011-02-25 | 2012-10-03 | 中国热带农业科学院热带生物技术研究所 | Diet health-care product and preparation method thereof |
| CN102293838A (en) * | 2011-08-29 | 2011-12-28 | 湖北康进药业有限责任公司 | Traditional Chinese medicine composition for reducing blood fat, and preparation method thereof |
| CN102423413A (en) * | 2012-01-04 | 2012-04-25 | 陈伯明 | Medicament for treating hyperlipemia and fatty liver and preventing atherosclerosis as well as applications thereof |
| CN102846879A (en) * | 2012-09-29 | 2013-01-02 | 广西梧州制药（集团）股份有限公司 | Composition for depressing blood fat |
| CN103861027A (en) * | 2012-12-18 | 2014-06-18 | 李玲玲 | Medicated bath prescription mainly treating hyperlipidemia and preparation method thereof |
| CN104138529A (en) * | 2013-08-09 | 2014-11-12 | 田艺儿 | Traditional Chinese medicine preparation capable of reducing blood lipid and preparation method of Traditional Chinese medicine preparation |
| CN104138529B (en) * | 2013-08-09 | 2016-01-20 | 田艺儿 | A kind of antilipemic Chinese herbal medicine preparation and preparation method thereof |
| CN107173806A (en) * | 2017-06-09 | 2017-09-19 | 耿成好 | A kind of health food and preparation method with blood fat reducing function |
| CN108404062A (en) * | 2018-06-11 | 2018-08-17 | 北京中医药大学 | Treat the Chinese medicine composition and its preparation method and application of hyperlipidemia |
| CN108404062B (en) * | 2018-06-11 | 2021-02-05 | 北京中医药大学 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method and application thereof |
| CN115462525A (en) * | 2022-09-19 | 2022-12-13 | 药侠谷(北京)医药文化有限公司 | Blood fat regulating composition and preparation method and application thereof |
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Open date: 20081001 |