CN102526276B - Anti-hypertension medicinal composition and preparation method for same - Google Patents
Anti-hypertension medicinal composition and preparation method for same Download PDFInfo
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- CN102526276B CN102526276B CN 201210006451 CN201210006451A CN102526276B CN 102526276 B CN102526276 B CN 102526276B CN 201210006451 CN201210006451 CN 201210006451 CN 201210006451 A CN201210006451 A CN 201210006451A CN 102526276 B CN102526276 B CN 102526276B
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Abstract
The invention relates to an anti-hypertension medicinal composition, which is prepared from the following raw materials: 26 grams of hawthorn, 20 grams of semen cassiae, 18 grams of kudzuvine root, 16 grams of epimedium herb, 12 grams of salvia miltiorrhiza, 10 grams of poria cocos, 8 grams of chrysanthemum, 6 grams of uncaria rhynchophylla, 6 grams of prunella vulgaris, 4 grams of radix bupleuri, 3 grams of schisandra chinensis, 3 grams of angelica, 2 grams of eucommia ulmoides oliv, 2 grams of burdock root and 1 gram of gentian. The medicinal composition is short in treatment course, high in overall response rate and low in reoccurrence after recovery. A preparation process for the medicinal composition is simple and low in raw material cost, the production cost is greatly decreased, and the economic burden of a patient is reduced.
Description
Technical field
The invention belongs to the biological medicine technology field, be specifically related to a kind of antihypertensive medical composite and preparation method thereof.
Background technology
Hypertension refers to that under quiescent condition systolic arterial pressure and/or diastolic pressure increase, it is a kind of chronic disease that serves as main performance with the lasting rising of arteriotony, often cause the pathological changes of vitals such as the heart, brain, kidney and corresponding consequence occurs, often with the fat and sugar metabolism disorder, long-term hypertension can cause cardiovascular disease such as myocardial infarction, coronary heart disease etc., renal arteriosclerosis be can also cause, thereby renal insufficiency, uremia etc. caused.
In China, first of the cerebrovascular resident cause of death.The whole nation is annual dead to surpass 1,000,000, and the patient of survival is about 5,000,000～6,000,000, wherein leaves deformity in various degree more than 80%, has caused white elephant for individual, family and society.And the main hazard factor of apoplexy is hypertension.Simultaneously, hypertension still is the fuse cord of multiple disease, and the onset risk of diseases such as coronary heart disease, heart failure and kidney disease is increased.Because the part hyperpietic there is no tangible clinical symptoms, hypertension be otherwise known as " the invisible killer " of human health.Therefore improve the understanding to hypertension, early prevention, treatment are in time had extremely important meaning.
Along with improving constantly of medical and health conditions, people more and more are concerned about the healthy of oneself.Increasing people begins to be concerned about whether the blood pressure of oneself is normal, whether suffers from the concurrent three-hypers disease of hypertension.Human beings'health in the hypertension serious harm, therefore improves the understanding to hypertension, and early prevention, treatment are in time had extremely important meaning.The method of the present treatment prophylaxis of hypertension of using always has multiple, comprises the living and diet adjusting, notes striking a proper balance between work and rest, and keeps enough sleeps, participates in work, physical work and physical training in power; The adjusting that is careful in one's diet is advisable with less salt, low animal fat diet, and is avoided into being rich in the food of cholesterol; Western medicine mainly contains diuretic hypotensive agent: hydrochlorothiazide, cyclopenthiazide; Nervus centralis and sympathetic inhibitor: reserpine, verticil, clonidine hydrochloride etc.Yet the Western medicine toxic and side effects is bigger, and cost is higher, and the patient is brought more burden.The Chinese herbal medicine giving consideration to both the incidental and fundamental, toxic and side effects is little, seeks effective, safe Chinese medicine composition, reaches the purpose of blood pressure lowering, has become the human common direction of pursuing.
Summary of the invention
In order to solve the technical problem of above-mentioned existence, the invention provides a kind of pharmaceutical composition of blood pressure lowering, the preparation method simple possible, with low cost, the regulating blood pressure that can make the patient effectively is in normal range, and convenient, practical, have no side effect.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of pharmaceutical composition of blood pressure lowering, it is got by following feedstock production, Fructus Crataegi 26, Semen Cassiae 20, Radix Puerariae 18, Herba Epimedii 16, Radix Salviae Miltiorrhizae 12, Poria 10, Flos Chrysanthemi 8, Ramulus Uncariae Cum Uncis 6, Spica Prunellae 6, Radix Bupleuri 4, Fructus Schisandrae Chinensis 3, Radix Angelicae Sinensis 3, the Cortex Eucommiae 2, Radix Arctii 2, Radix Gentianae 1.
Chinese medicine composition of the present invention can adopt respectively the distinguish the flavor of medical material of conventional method in will writing out a prescription to carry out compatibility in proportion, makes various clinical suitable dosage forms by existing preparation process, and the used medical material of respectively distinguishing the flavor of is the Chinese crude drug that commercially available process is up to the standards.
Preparation of pharmaceutical compositions method of the present invention preferably includes following steps:
The above-mentioned raw materials medicine is made medicated powder according to a conventional method respectively, cross 120 mesh sieves, take by weighing in proportion, stirring and evenly mixing, every 100g add refined honey 40g and 10g water, general ball, and the heavy 5g of every ball, 60 ℃ of vacuum dryings namely get pill of the present invention.
Dosage form and usage: drug agents type of the present invention is the ball type, three times on the one, and one after each meal, each two, 20 days is a course for the treatment of.
The excellent results of Chinese medicine composition of the present invention and preparation method thereof is:
Medicament of the present invention is made by pure Chinese medicine, and each component meets pharmacopeia method relevant regulations, utilizes the compatibility effect of the Chinese medicine of respectively distinguishing the flavor of, and does not contain chemical components, does not contain hormone, has no side effect, and treating both the principal and secondary aspects of a disease reaches the effect of better blood pressure lowering; Chinese medicine composition medicament short treating period of the present invention, the total effective rate height, more the back is difficult for recurrence; Technology of the present invention is simple, has reduced production cost, has alleviated patient's financial burden.
The specific embodiment
Below come detailed explanation the present invention by specific embodiment, but as the restriction to content of the present invention.
Embodiment 1
A kind of pharmaceutical composition of blood pressure lowering, it is got by following feedstock production, Fructus Crataegi 26, Semen Cassiae 20, Radix Puerariae 18, Herba Epimedii 16, Radix Salviae Miltiorrhizae 12, Poria 10, Flos Chrysanthemi 8, Ramulus Uncariae Cum Uncis 6, Spica Prunellae 6, Radix Bupleuri 4, Fructus Schisandrae Chinensis 3, Radix Angelicae Sinensis 3, the Cortex Eucommiae 2, Radix Arctii 2, Radix Gentianae 1.
The aforementioned pharmaceutical compositions preparation method comprises the steps:
The above-mentioned raw materials medicine is made medicated powder according to a conventional method respectively, cross 120 mesh sieves, take by weighing in proportion, stirring and evenly mixing, every 100g add refined honey 40g and 10g water, general ball, and the heavy 5g of every ball, 60 ℃ of vacuum dryings namely get pill of the present invention.
Dosage form and usage: drug agents type of the present invention is the ball type, three times on the one, and one after each meal, each two, 20 days is a course for the treatment of.
Embodiment 2
Clinical practice:
Case is selected: select the 65 routine hyperpietics of city institute of traditional Chinese medicine that the curative effect of the Chinese medicine composition of the embodiment of the invention 1 has been carried out clinical observation.
The case grouping: 65 routine cases are divided into two groups at random, and 30 examples are organized in treatment, matched group 35 examples.All case is diagnosed as high blood pressure disease all according to the diagnostic criteria of " new Chinese medicine clinical guidance principle ".
Diagnostic criteria: systolic pressure is equal to or higher than 160mmHg, and diastolic pressure is equal to or higher than 95mmHg, and both have one through examining, and can be diagnosed as hypertension.
Therapeutic Method: the control drug group adopts antihypertensive tablet, one time 4, three times on the one; Medicine group of the present invention adopts the embodiment of the invention 1 medicine to treat, and three times on the one, each two, 20 days is a course for the treatment of.
Criterion of therapeutical effect: according to the criterion of therapeutical effect in " new Chinese medicine clinical guidance principle ", produce effects: 1. more than the diastolic pressure decline 10mmHg, and reach normal range; Though 2. diastolic pressure is not near normal, with decline 20mmHg or more than, need possess wherein 1; Effectively: 1. diastolic pressure descends not as good as 10mmHg, but to reach normal range; 2. decline 10～19mmHg before diastolic pressure is treated, but do not reach normal range; 3. decline 30mmHg before systolic pressure is treated need possess wherein 1; Invalid: as not reach above standard.Two groups of case treatment back curative effect comparative results see Table 1.
Table 1 liang group case treatment back curative effect relatively
Statistical result showed, medicine group effective percentage of the present invention is 85.7%, and control drug group effective percentage is 73.3%, and medicine group curative effect of the present invention obviously is better than the control drug group, and two group differences are remarkable, P＜0.05.
Model case
1, the village so-and-so, 49 years old, the man, headache and dizzy 1 year increases the weight of to come hospital admission recently, 190/100mmHg is diagnosed as hypertension.Take medicine of the present invention after course for the treatment of, blood pressure is 135/85mmHg, and dose reduces half and continues to take a course for the treatment of, and bounce-back is not seen in drug withdrawal later six months.
2, Song, 60 years old, the male.Suffer from hypertension surplus in the of ten year, often feel dizzy headache.Fluctuation of blood pressure is diagnosed as hypertension between 190/95-210/105mmHg.Take medicine of the present invention after course for the treatment of, blood pressure is 145/90mmHg, continues to take a course for the treatment of, and blood pressure recovers normal level, and bounce-back is not seen in drug withdrawal later six months.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (2)
1. the pharmaceutical composition of a blood pressure lowering, it is characterized in that, described pharmaceutical composition gets Fructus Crataegi 26, Semen Cassiae 20, Radix Puerariae 18, Herba Epimedii 16, Radix Salviae Miltiorrhizae 12, Poria 10, Flos Chrysanthemi 8, Ramulus Uncariae Cum Uncis 6, Spica Prunellae 6, Radix Bupleuri 4, Fructus Schisandrae Chinensis 3, Radix Angelicae Sinensis 3, the Cortex Eucommiae 2, Radix Arctii 2, Radix Gentianae 1 by the following raw material medicaments preparation;
Preparation method is carried out according to following steps: the above-mentioned raw materials medicine is made medicated powder according to a conventional method respectively, cross 120 mesh sieves, take by weighing in proportion, stirring and evenly mixing, every 100g add refined honey 40g and 10g water, general ball, and the heavy 5g of every ball, 60 ℃ of vacuum dryings are namely.
2. the application of the described pharmaceutical composition of claim 1 in the preparation Altace Ramipril.
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| CN 201210006451 CN102526276B (en) | 2012-01-11 | 2012-01-11 | Anti-hypertension medicinal composition and preparation method for same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103127337B (en) * | 2013-03-14 | 2014-07-30 | 新乡医学院 | Chinese medicament pills for lowering blood pressure |
| CN103380903A (en) * | 2013-06-29 | 2013-11-06 | 安徽皖山食品有限公司 | Chrysanthemum hypertension paste and preparation method thereof |
| CN103417682B (en) * | 2013-08-09 | 2014-09-17 | 田艺儿 | Traditional Chinese medicine preparation for reducing blood pressure and preparation method thereof |
| CN103461788B (en) * | 2013-08-13 | 2014-08-06 | 青岛福加德面粉有限公司 | Flour compound suitable for hypertensive disease patients |
| CN108619400A (en) * | 2018-07-24 | 2018-10-09 | 李克明 | It is a kind of can be with the Traditional Chinese medicinal liquor of reducing pressure and sugar kidney tonifying |
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| CN1136001C (en) * | 2000-12-27 | 2004-01-28 | 卢庆来 | Hypertension-treating medicine |
| JP2002114697A (en) * | 2001-05-15 | 2002-04-16 | Nakamoto Chin | Composition of shichifuku-sanju liquor and shichifuku- sanju tablet and its efficacy |
| WO2006081739A1 (en) * | 2005-02-06 | 2006-08-10 | Xinfu Guo | A composition for treating or preventing hyperlipemia, hypertension and hepatic adipose infiltration |
| US20080267939A1 (en) * | 2006-09-29 | 2008-10-30 | Jose Angel Olalde Rangel | Synergistic anti-hypertensive phyto-nutraceutical composition |
| CN100512858C (en) * | 2006-11-24 | 2009-07-15 | 王建兴 | Preparation of Chinese traditional medicine for treating cardiovascular disease and cerebrovascular disease |
| JP2008214198A (en) * | 2007-02-28 | 2008-09-18 | Suzuka Univ Of Medical Science | Composition characterized by containing morus plants, lotus plants, crataegus plants, and salvia plants |
| CN101129433A (en) * | 2007-09-12 | 2008-02-27 | 青岛宝德生物科技开发有限公司 | Method for extracting active component of edible burdock |
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Effective date of registration: 20141230 Address after: 226500 Jiangsu city of Rugao Province Town North Street Flower Market Road No. 20 Patentee after: Jiangsu Xinyuan Pharmaceutical Co., Ltd. Address before: 276000 Linyi people's Hospital of Shandong Province Patentee before: Zhang Jishu |