CN101954051B - Traditional Chinese medicinal composition used for curing cerebral thrombosis - Google Patents

Abstract

The invention discloses a traditional Chinese medicinal composite used for curing cerebral thrombosis. Aiming at the pathogenesiss of cerebral thrombosis and based on the principle of symptomatic treatment, motherwort herb, the root of herbaceous peony, radix ophiopogonis, Achyranthes bidentata, curcuma aromatica, uncaria, astragalus root and the root of red-rooted salvia are selected to prepare a decoction; raw oyster, tortoise shell, garter snake, Chinese polyphaga are used to prepare capsules, and the decoction and the capsules are taken at the same time. Through the clinic experiments and observations, the composite has better curative effect, the total effective rate is 91.5%, the composite has no side effect, is safe and cheap and is suitable for clinical popularization and application.

Description

A kind of Chinese medicine composition for the treatment of cerebral thrombosis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of cerebral thrombosis.

Background technology

Cerebral thrombosis is a serious harm the people of the world health, influences the cerebrovascular accident disease of the chronic progressive external of life-span and quality of life, because it has the sickness rate height, and the disability rate height, the relapse rate height, mortality rate height and complication be a kind of like this characteristics how.Because taking place, the patient of cerebral thrombosis mostly is middle-aged and elderly people, wherein the old people with 60-70 year is maximum, so in selection to the cerebral thrombosis medicine, be that doctor, patient and family members are very careful, because old people's Liver and kidney is to be unable to stand side effects of pharmaceutical drugs for a long time to its damage that causes, and this side effect is very obvious in Western medicine.So treatment cerebral thrombosis, the expert of 90% cardiovascular and cerebrovascular disease treatment aspect can advise that the patient is when using one to two kind of indispensable Western medicine, also must take the Chinese Traditional Medicines of the every function of a kind of energy comprehensive care cerebrovascular, play Synergistic treatment, reach the therapeutic effect of efficacy enhancing and toxicity reducing.Chinese medicine, especially through genuine drawing materials, the big compound recipe modern Chinese medicine that modern crafts are produced, because its drug effect is obvious, safety is good, the Drug resistance height, long-lasting remarkable advantages such as strong has become the effectively main medication of treatment of cerebral thrombus forming patient.But treat cerebral thrombosis Chinese medicine at present and have all that curative effect is slow, the unfavorable problem of therapeutic effect.

Summary of the invention

The Chinese medicine composition that the purpose of this invention is to provide a kind of more efficiently treatment cerebral thrombosis.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment cerebral thrombosis is made up of following parts by weight of Chinese traditional medicine:

Herba Leonuri 10-15 branch, Radix Paeoniae Alba 10-15 branch, Radix Ophiopogonis 5-10 branch, Radix Achyranthis Bidentatae 5-10 branch, Radix Curcumae 5-10 branch, Ramulus Uncariae Cum Uncis 3-7 branch, Radix Astragali 3-7 branch, Radix Salviae Miltiorrhizae 10-15 branch, Concha Ostreae 3-5 branch, Carapax et Plastrum Testudinis 5-7 branch, Zaocys 3-5 branch, Eupolyphaga Seu Steleophaga 5-7 branch.

The consumption of Chinese medicine composition each component of the present invention proves that through a large amount of clinical practices the optimum amount of preferred each component is:

Herba Leonuri 13 minutes, the Radix Paeoniae Alba 13 minutes, 7 minutes Radix Ophiopogonis, Radix Achyranthis Bidentatae 7 minutes, Radix Curcumae 7 minutes, Ramulus Uncariae Cum Uncis 5 minutes, the Radix Astragali 5 minutes, Radix Salviae Miltiorrhizae 13 minutes, Concha Ostreae 4 minutes, Carapax et Plastrum Testudinis 6 minutes, Zaocys 4 minutes, Eupolyphaga Seu Steleophaga 6 minutes.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to make oral preparations, Concha Ostreae, Zaocys, Eupolyphaga Seu Steleophaga, Carapax et Plastrum Testudinis, and above medicine is ground into powder, sieves, and incapsulates; Herba Leonuri, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Achyranthis Bidentatae, Radix Curcumae, Ramulus Uncariae Cum Uncis, the Radix Astragali, Radix Salviae Miltiorrhizae, more than each medicine add water decoction and concentrate to adopt bottled.

In technical solution of the present invention, the Herba Leonuri silt of invigorating blood circulation, dispel; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant; Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; The Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards; Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving; Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; Radix Astragali invigorating QI to consolidate the body surface resistance, the diuresis poison holding, it is weak to be used for the deficiency of vital energy; The Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Concha Ostreae: tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating; Zaocys dispels the wind, collateral dredging, relieving convulsion; Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones; The Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, the reinforcing the heart of nourishing blood, consolidating channel for hemostasis.

Clinical data

1, physical data: each 118 example of treatment group and matched group are my patient of institute stochastic sampling grouping.Male 70 examples are organized in treatment, women 48 examples; Maximum 78 years old age, minimal ages 42 years old, 56 years old mean age; The course of disease 4 hours to 10 days, average (2.76 ± 0.72) sky; Wherein with hypertension 60 examples, coronary heart disease 48 examples, hyperlipidemia 89 examples, diabetes 32 examples.Matched group 118 examples, male 72 examples, women 46 examples; Maximum 80 years old age, minimum 43 years old, 57 years old mean age; The course of disease 3.5 hours to 9 days, average (2.15 ± 0.63) sky; Hypertension 62 examples wherein, coronary heart disease 52 examples, hyperlipidemia 91 examples, diabetes 31 examples.Two groups in sex, age, symptom, sign and complication no significant difference (P＞0.05), has comparability.

2, diagnostic criteria is drafted diagnostic criteria [1] by the 4th national cerebrovascular academic conference in October nineteen ninety-five, turns out to be cerebral thrombosis through head CT or MRI.

3, Therapeutic Method

Treatment group: in Primary Care, take Chinese medicine preparation of the present invention, promptly grind the capsule of making into powder by Concha Ostreae, Carapax et Plastrum Testudinis, Zaocys, Eupolyphaga Seu Steleophaga; Add water decoction by Herba Leonuri, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Achyranthis Bidentatae, Radix Curcumae, Ramulus Uncariae Cum Uncis, the Radix Astragali, each medicine of Radix Salviae Miltiorrhizae and concentrate, every bottled 100 milliliters, 100 milliliters of day clothes, divide the secondary clothes, 7 of the capsules of at every turn taking after mixing it with water, 15 days is a course of treatment, twice 3-5 days at interval course of treatment, add up curative effect after three courses of treatment.

Matched group; Take aspirin, piracetam on the basis of Primary Care, 15 days is a course of treatment, twice 3-5 days at interval course of treatment, adds up curative effect after three courses of treatment.

4, efficacy assessment standard

According to " clinical disease diagnosis is cured improvement " standard.1. cure substantially: consciousness recovery is normal, Myodynamia recovery IV～V level, and life can be taken care of oneself.2. produce effects: consciousness recovery is normal, and muscular strength improves more than the II level, and life is taken care of oneself substantially.3. take a turn for the better: consciousness recovery is normal, and muscular strength improves the II level, can't take care of oneself.4. invalid: treating last symptom does not have obvious improvement.

5, therapeutic outcome

Treatment group total effective rate 91.5%, obvious effective rate are 79.6%; Matched group total effective rate 74.6%, obvious effective rate are 54.2%.Learn by statistics and handle, the treatment group is than matched group (P＜0.05), and two groups apparent side effect (seeing Table 1) all do not occur.

Table 1 treatment group and the contrast of matched group clinical efficacy

Observe in two groups of treatment clinical cardinal symptoms in front and back and the sign index, disturbance of consciousness, vision and disturbance of visual field, hemiparesis or bilateral quadriplegia, two groups of Comparison of therapeutic of speech disorder have significant difference (seeing Table two).

The table 2 liang clinical cardinal symptom of group, sign Comparison of therapeutic

6, toxicity

In clinical observation treatment group 118 examples, 69 customary liver functions, blood routine examination, all no abnormal variation, illustrate use this medicine after whole body have no adverse reaction.

7, model case

Case one: Lee, woman, 61 years old, the worker of enterprise.Suffered from cerebral thrombosis in 2008, my institute's treatment is changeed, finding when coming to the large hospital treatment of too much institute in front and back in March, 2009: the unable inconvenient activity of left side upper and lower extremities, and hand-held crutch walking is very slow, and sitting down stands up needs my old man to assist babble in.Check patient's muscular strength IV level, 8 kilograms of grips, lower limb are pedaled 10 kilograms of power.Through the treatment of three courses of treatment, the homonymy muscular strength reaches the V level, and grip reaches 17 kilograms, and the power of pedaling reaches 42 kilograms, and it is clearer to speak, and rises and sits freely.

Case two: Wu: burst in 56 years old is spat out white foams, and mountain, left side lower limb lose after the movable function companion facial hemiparalysis provincial capital large hospital and are in hospital to leave hospital after failing to respond to any medical treatment in 15 days and go home the court's prescription on individual diagnosis over second day of leaving hospital.Check blood pressure 140-70 left side upper and lower extremities afunction, facial hemiparalysis, can out-of-bed activity after treating two courses of treatment, fully recover after treating three courses of treatment.

The specific embodiment

Embodiment one:

Get Concha Ostreae 40 grams, Carapax et Plastrum Testudinis 60 grams, Zaocys 40 grams, Eupolyphaga Seu Steleophaga 60 grams, above medicine is ground mixing into powder, incapsulates.

Get Herba Leonuri 130 gram, the Radix Paeoniae Alba 130 grams, Radix Ophiopogonis 70 gram, Radix Achyranthis Bidentatae 70 grams, Radix Curcumae 70 grams, Ramulus Uncariae Cum Uncis 50 grams, the Radix Astragali 50 grams, Radix Salviae Miltiorrhizae 130 grams, above Chinese medicine adds 3500 milliliters of decocts of water, and 600 milliliters of bottlings of simmer down to when taking, utilize medicinal liquid to take capsule.

Claims (2)

1. Chinese medicine composition for the treatment of cerebral thrombosis, it is characterized in that getting Herba Leonuri 10-15 part, Radix Paeoniae Alba 10-15 part, Radix Ophiopogonis 5-10 part, Radix Achyranthis Bidentatae 5-10 part, Radix Curcumae 5-10 part, Ramulus Uncariae Cum Uncis 3-7 part, Radix Astragali 3-7 part, Radix Salviae Miltiorrhizae 10-15 part add water decoction concentrate adopt bottled; Get Concha Ostreae 3-5 part, Carapax et Plastrum Testudinis 5-7 part, Zaocys 3-5 part, Eupolyphaga Seu Steleophaga 5-7 part and grind and do not sieve, incapsulate.

2. a kind of Chinese medicine composition for the treatment of cerebral thrombosis according to claim 1, it is characterized in that getting 13 parts of 13 parts of Herba Leonuris, 13 parts of the Radix Paeoniae Albas, 7 parts of Radix Ophiopogonis, 7 parts of Radix Achyranthis Bidentataes, 7 parts of Radix Curcumaes, 5 parts of Ramulus Uncariae Cum Uncis, 5 parts of the Radixs Astragali, Radix Salviae Miltiorrhizae add water decoction concentrate adopt bottled; Get 4 parts of Concha Ostreae, 6 parts of Carapax et Plastrum Testudiniss, 4 parts of Zaocyss, Eupolyphaga Seu Steleophaga and grind for 6 parts and do not sieve, incapsulate.