CN101461919B - Medicament composition for treating male climacteric syndrome and delaying age - Google Patents
Medicament composition for treating male climacteric syndrome and delaying age Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating male menopause syndrome and delaying senility. The pharmaceutical composition is prepared from epimedium, rhodiola root, sea buckthorne, fructus alpiniae oxyphyllae, Chinese yam, ginkgo seed, ganoderma lucidum spore powder, fleece-flower root, dogwood, salvia miltiorrhiza, radix morindae and eucommia bark. The raw material drugs are added with the prior accessories, and prepared into various clinically acceptable dosage forms by the prior process, such as capsule, granule, tablet, oral liquid preparation, and the like. The invention also provides application of the pharmaceutical composition to prepare medicaments for treating the male menopause syndrome and delaying the senility, enhancing immune function, and alleviating fatigue.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of pharmaceutical composition for the treatment of male climacteric syndrome and slow down aging, enhancing immunity, fatigue alleviating.
Background technology
The people with advancing age, performance has the physiological phenomenon of different times, male menopause is to carry out the transition to one section old veryer long unavoidable age level, physiological obvious change in this period is vigorous gradually to weakening from the reproduction function, some physiological change of male or subjective symptoms are not fairly obvious, therefore, male menopause physiological change and relevant disease are left in the basket easily.Along with the progress of society and the quickening of work rhythm of life, related symptoms and disease that male menopause occurs are on the rise, as cardiovascular disease, diabetes, senile dementia, remind the care of strengthening the climacteric male to have urgency.
The male causes the variation of endocrine bodies of gland such as hypothalamus, hypophysis, adrenal gland in physiological sex hormones secretion minimizing of climacteric thereupon, and the target organ of general hormone is organized a series of variations are taken place thereupon, the climacteric syndrome associated conditions occurs.Show many-sided variations such as emotion, psychology, interest, energy, appetite and libido, concluding common sympton has: injured or ill back rehabilitation duration is long, nervous anxiety, irritability; Libido descends and disappears; The time of feeling passes soon; Hypomnesis, absent minded; Anxiety sense or fear increase; Feel fat, weight increase; It is not good enough to sleep; Irresolute; Lose interest and self-confidence.
If note the health care conditioning, these phenomenons can alleviate or not occur.Previously general employing androgen supplement therapy (TST), but are difficult for consumption and service time adjusting, pay close attention to some extent the male menopause relevant disease is more preceding in recent years, for Chinese medicine research male menopause health provides opportunity.
The study on prevention of Chinese medicine is many with the hepatic and renal YIN deficiency, hyperactivity of deficient fire; Stagnation of liver-QI with deficiency of the spleen, the essence and blood imbalance; Deficiency of kidney-essence, the deficiency of both YIN and YANG classification therapy adopts plus-minuss such as ZHIBAI DIHUANG WAN, QIJU DIHUANG WAN, bupleurum powder for relieving liver-qi, JINGUI SHENQI WAN, but the control Chinese medicine preparation that is exclusively used in the male menopause disease still belongs to rarely.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition, and another purpose of the present invention is to provide the purposes of this pharmaceutical composition.
The present invention seeks to be achieved through the following technical solutions
The crude drug of pharmaceutical composition of the present invention consists of:
Herba Epimedii 20-50 weight portion Radix Rhodiolae 5-15 weight portion Fructus Hippophae 2-9 weight portion
Fructus Alpiniae Oxyphyllae 2-9 weight portion Rhizoma Dioscoreae 2-9 weight portion Semen Ginkgo 1-5 weight portion
Ganoderma spore powder 1-5 weight portion Radix Polygoni Multiflori 2-9 weight portion Fructus Corni 2-9 weight portion
Radix Salviae Miltiorrhizae 5-15 weight portion Radix Morindae Officinalis 2-9 weight portion Cortex Eucommiae 5-15 weight portion.
Above-mentioned raw materials medicine preferred weight proportioning is as follows:
Herba Epimedii 35 weight portion Radix Rhodiolaes 10 weight portion Fructus Hippophaes 5 weight portions
Fructus Alpiniae Oxyphyllae 5 weight portion Rhizoma Dioscoreaes 5 weight portion Semen Ginkgoes 2.5 weight portions
Ganoderma spore powder 2.5 weight portion Radix Polygoni Multiflori 5 weight portion Fructus Corni 5 weight portions
The Radix Salviae Miltiorrhizae 10 weight portion Radix Morindae Officinaliss 5 weight portion Cortexs Eucommiae 10 weight portions.
Above-mentioned raw materials medicine preferred weight proportioning is as follows:
Herba Epimedii 25 weight portion Radix Rhodiolaes 14 weight portion Fructus Hippophaes 3 weight portions
Fructus Alpiniae Oxyphyllae 8 weight portion Rhizoma Dioscoreaes 4 weight portion Semen Ginkgoes 4 weight portions
Ganoderma spore powder 2 weight portion Radix Polygoni Multiflori 7 weight portion Fructus Corni 2.5 weight portions
The Radix Salviae Miltiorrhizae 13 weight portion Radix Morindae Officinaliss 3.5 weight portion Cortexs Eucommiae 6 weight portions.
Above-mentioned raw materials medicine preferred weight proportioning is as follows:
Herba Epimedii 45 weight portion Radix Rhodiolaes 6 weight portion Fructus Hippophaes 8 weight portions
Fructus Alpiniae Oxyphyllae 3 weight portion Rhizoma Dioscoreaes 7 weight portion Semen Ginkgoes 2 weight portions
Ganoderma spore powder 4 weight portion Radix Polygoni Multiflori 4 weight portion Fructus Corni 6 weight portions
The Radix Salviae Miltiorrhizae 7 weight portion Radix Morindae Officinaliss 2.5 weight portion Cortexs Eucommiae 14 weight portions.
Get pharmaceutical composition above-mentioned raw materials medicine of the present invention, add conventional adjuvant, be prepared into clinical acceptable various dosage forms according to common process, as: capsule, granule, tablet, oral liquid, aqueous injection or lyophilized injectable powder.
Pharmaceutical composition of the present invention is a kind of based on the auxilliary kidney of Chinese medicine, be used for andropausal product, it is characterized in that having " integration of edible and medicinal herbs ", the Chinese prescription of " control synchronously ", to improve the male menopause health quality, improve male menopause cardio and vascular function, enhancing immunity, defying age, memory reinforcing, resisting fatigue, improve inadequate sexual desire, the equal tool of bone density improving obviously acts on.If actively and correctly prevent and treat climacteric syndrome and relevant disease in stage climacteric, meaning that will be positive to having of senile dementia.The preparation of preparation of pharmaceutical compositions of the present invention has overcome the big drawback of Chinese patent medicine dose, has the active ingredient height, takes safe, with strong points, suitable crowd characteristics widely.
Per os gives the medicament composition capsule preparation 30d of the present invention of mice various dose, can improve mice organ weight ratio value and thymus ratio, the humoral immune function of mice, monokaryon-macrophage carefully can, NK cytoactive measurement result is positive.This shows that pharmaceutical composition of the present invention has the function of enhancing immunity.
Per os gives the medicament composition granule preparation 30d of the present invention of mice various dose, the initial data heterogeneity of variance, process is to after the number conversion, carry out homogeneity test of variance, meet the neat requirement of variance, carry out statistical disposition with the comparative approach in twos of mean between one factor analysis of variance method and a plurality of experimental group and matched group.By table 10 as seen, relatively, difference has significance (P＜0.05), compares in 1.050g/kg BW group and 0.000g/kg BW group between 0.350g/kg BW group and 0.000g/kg BW group, and difference has utmost point significance (P＜0.01).Relatively, difference does not have significance (P＞0.05) between 0.035g/kg BW group and 0.000g/kg BW group.It is pharmaceutical composition of the present invention all can increase the Mouse Liver glycogen in 0.350g/kg BW group, 1.050g/kgBW group storage level.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The 38 routine clinical observations of experimental example 1 water decoction treatment male climacteric syndrome of the present invention
The male causes the variation of endocrine bodies of gland such as hypothalamus, hypophysis, adrenal gland in physiological sex hormones secretion minimizing of climacteric thereupon, and the target organ of general hormone is organized a series of variations of generation immediately, the climacteric syndrome associated conditions occurs.Show many-sided variations such as emotion, psychology, interest, energy, appetite and libido, concluding common sympton has: injured or ill back rehabilitation duration is long, nervous anxiety, irritability; Libido descends and disappears; The time of feeling passes soon; Hypomnesis, absent minded; Anxiety sense or fear increase; Feel fat, weight increase; It is not good enough to sleep; Irresolute; Lose interest and self-confidence.
So far in November, 1999 of in January, 1999, researcher was as follows in outpatient service observation water decoction treatment of the present invention male climacteric syndrome 38 routine final reports:
1, clinical data:
This organizes 38 routine patient age between 50 to 65 years old, and the mean age is 57.5 years old.
2, diagnostic criteria:
Clinical manifestation: the present domestic unified male menopause symptom standard that still do not have, according to the nervous anxiety of the symptom of international JedDiamondg conclusion: a., irritability; B. hypomnesis, absent minded; C. anxiety sense or fear increase; D. it is not good enough to sleep; E. irresolute; F. libido descends and disappears; G. injured or ill back rehabilitation duration table; H. lose interest and self-confidence; I. the time of feeling passes soon; J. feel fat, weight increase, get rid of the similar symptom of its disease.
Lab testing: the inspection of male genetic endocrine, bone metabolism, cardiovascular coherence check
1, Therapeutic Method: by the unified water decoction of supervising of the present invention of hospital, the course of treatment and instructions of taking: taking every day three times, is a course of treatment all around
2, criterion of therapeutical effect:
Cure: the symptom after taking medicine complete obiteration, the positive index of laboratory recovers normal; Take a turn for the better: primary symptom obviously alleviates, other transference cure or alleviate, and positive index is improved; Invalid: symptom and inspection index do not have change.
3, therapeutic outcome: statistical analysis after two weeks of drug withdrawal, cure 21 examples, 16 examples that take a turn for the better, invalid 1 example, total effective rate 97%.
Following embodiment all can realize the described effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: the preparation of capsule
Herba Epimedii 35kg Radix Rhodiolae 10kg Fructus Hippophae 5kg Fructus Alpiniae Oxyphyllae 5kg
Rhizoma Dioscoreae 5kg Semen Ginkgo 2.5kg Ganoderma spore powder 2.5kg Radix Polygoni Multiflori 5kg
Fructus Corni 5kg Radix Salviae Miltiorrhizae 10kg Radix Morindae Officinalis 5kg Cortex Eucommiae 10kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, make powder and go into capsule according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
Embodiment 2: the preparation of capsule
Herba Epimedii 25kg Radix Rhodiolae 14kg Fructus Hippophae 3kg Fructus Alpiniae Oxyphyllae 8kg
Rhizoma Dioscoreae 4kg Semen Ginkgo 4kg Ganoderma spore powder 2kg Radix Polygoni Multiflori 7kg
Fructus Corni 2.5kg Radix Salviae Miltiorrhizae 13kg Radix Morindae Officinalis 3.5kg Cortex Eucommiae 6kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, make powder and go into capsule according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
Embodiment 3: the preparation of capsule
Herba Epimedii 45kg Radix Rhodiolae 6kg Fructus Hippophae 8kg Fructus Alpiniae Oxyphyllae 3kg
Rhizoma Dioscoreae 7kg Semen Ginkgo 2kg Ganoderma spore powder 4kg Radix Polygoni Multiflori 4kg
Fructus Corni 6kg Radix Salviae Miltiorrhizae 7kg Radix Morindae Officinalis 2.5kg Cortex Eucommiae 14kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, make powder and go into capsule according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
Embodiment 4: the preparation of granule
Herba Epimedii 35kg Radix Rhodiolae 10kg Fructus Hippophae 5kg Fructus Alpiniae Oxyphyllae 5kg
Rhizoma Dioscoreae 5kg Semen Ginkgo 2.5kg Ganoderma spore powder 2.5kg Radix Polygoni Multiflori 5kg
Fructus Corni 5kg Radix Salviae Miltiorrhizae 10kg Radix Morindae Officinalis 5kg Cortex Eucommiae 10kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, be prepared into aqueous injection according to common process.
Embodiment 5: the preparation of tablet
Herba Epimedii 45kg Radix Rhodiolae 6kg Fructus Hippophae 8kg Fructus Alpiniae Oxyphyllae 3kg
Rhizoma Dioscoreae 7kg Semen Ginkgo 2kg Ganoderma spore powder 4kg Radix Polygoni Multiflori 4kg
Fructus Corni 6kg Radix Salviae Miltiorrhizae 7kg Radix Morindae Officinalis 2.5kg Cortex Eucommiae 14kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, be prepared into tablet according to common process.
Embodiment 6: the preparation of oral liquid
Herba Epimedii 25kg Radix Rhodiolae 14kg Fructus Hippophae 3kg Fructus Alpiniae Oxyphyllae 8kg
Rhizoma Dioscoreae 4kg Semen Ginkgo 4kg Ganoderma spore powder 2kg Radix Polygoni Multiflori 7kg
Fructus Corni 2.5kg Radix Salviae Miltiorrhizae 13kg Radix Morindae Officinalis 3.5kg Cortex Eucommiae 6kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, be prepared into granule according to common process.
Embodiment 7: the preparation of aqueous injection
Herba Epimedii 22kg Radix Rhodiolae 6kg Fructus Hippophae 8kg Fructus Alpiniae Oxyphyllae 7kg
Rhizoma Dioscoreae 3kg Semen Ginkgo 2kg Ganoderma spore powder 4kg Radix Polygoni Multiflori 4kg
Fructus Corni 4kg Radix Salviae Miltiorrhizae 14kg Radix Morindae Officinalis 8kg Cortex Eucommiae 13kg
Get the above-mentioned raw materials medicine, add conventional adjuvant, be prepared into aqueous injection according to common process.
Embodiment 8: the preparation of capsule
Herba Epimedii 49kg Radix Rhodiolae 14kg Fructus Hippophae 3kg Fructus Alpiniae Oxyphyllae 4kg
Rhizoma Dioscoreae 8kg Semen Ginkgo 5kg Ganoderma spore powder 2kg Radix Polygoni Multiflori 4kg
Fructus Corni 8kg Radix Salviae Miltiorrhizae 14kg Radix Morindae Officinalis 3.5kg Cortex Eucommiae 6kg.
Get the above-mentioned raw materials medicine, add conventional adjuvant, make powder and go into capsule according to common process decocting in water, precipitate with ethanol, oven dry pulverizing.
Claims (8)
1. pharmaceutical composition for the treatment of male climacteric syndrome and slow down aging is characterized in that this pharmaceutical composition crude drug consists of:
Herba Epimedii 20-50 weight portion Radix Rhodiolae 5-15 weight portion Fructus Hippophae 2-9 weight portion
Fructus Alpiniae Oxyphyllae 2-9 weight portion Rhizoma Dioscoreae 2-9 weight portion Semen Ginkgo 1-5 weight portion
Ganoderma spore powder 1-5 weight portion Radix Polygoni Multiflori 2-9 weight portion Fructus Corni 2-9 weight portion
Radix Salviae Miltiorrhizae 5-15 weight portion Radix Morindae Officinalis 2-9 weight portion Cortex Eucommiae 5-15 weight portion.
2. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of:
Herba Epimedii 35 weight portion Radix Rhodiolaes 10 weight portion Fructus Hippophaes 5 weight portions
Fructus Alpiniae Oxyphyllae 5 weight portion Rhizoma Dioscoreaes 5 weight portion Semen Ginkgoes 2.5 weight portions
Ganoderma spore powder 2.5 weight portion Radix Polygoni Multiflori 5 weight portion Fructus Corni 5 weight portions
The Radix Salviae Miltiorrhizae 10 weight portion Radix Morindae Officinaliss 5 weight portion Cortexs Eucommiae 10 weight portions.
3. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of:
Herba Epimedii 25 weight portion Radix Rhodiolaes 14 weight portion Fructus Hippophaes 3 weight portions
Fructus Alpiniae Oxyphyllae 8 weight portion Rhizoma Dioscoreaes 4 weight portion Semen Ginkgoes 4 weight portions
Ganoderma spore powder 2 weight portion Radix Polygoni Multiflori 7 weight portion Fructus Corni 2.5 weight portions
The Radix Salviae Miltiorrhizae 13 weight portion Radix Morindae Officinaliss 3.5 weight portion Cortexs Eucommiae 6 weight portions.
4. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition crude drug consists of:
Herba Epimedii 45 weight portion Radix Rhodiolaes 6 weight portion Fructus Hippophaes 8 weight portions
Fructus Alpiniae Oxyphyllae 3 weight portion Rhizoma Dioscoreaes 7 weight portion Semen Ginkgoes 2 weight portions
Ganoderma spore powder 4 weight portion Radix Polygoni Multiflori 4 weight portion Fructus Corni 6 weight portions
The Radix Salviae Miltiorrhizae 7 weight portion Radix Morindae Officinaliss 2.5 weight portion Cortexs Eucommiae 14 weight portions.
5. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that getting the above-mentioned composition crude drug, add conventional adjuvant,, make capsule, granule, tablet, oral liquid, aqueous injection or lyophilized injectable powder according to common process.
6. as the arbitrary described preparation of drug combination method of claim 1-4, it is characterized in that this method is: get crude drug, add conventional adjuvant,, make capsule, granule, tablet, oral liquid, aqueous injection or lyophilized injectable powder according to common process.
7. as the application of the arbitrary described pharmaceutical composition of claim 1-4 in the medicine of preparation treatment male climacteric syndrome.
8. has application in the medicine of slow down aging, enhancing immunity or fatigue alleviating as the arbitrary described pharmaceutical composition of claim 1-4 in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103020435A CN101461919B (en) | 2007-12-20 | 2007-12-20 | Medicament composition for treating male climacteric syndrome and delaying age |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007103020435A CN101461919B (en) | 2007-12-20 | 2007-12-20 | Medicament composition for treating male climacteric syndrome and delaying age |
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| CN101461919A CN101461919A (en) | 2009-06-24 |
| CN101461919B true CN101461919B (en) | 2011-02-23 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244420A (en) * | 1999-02-04 | 2000-02-16 | 盘锦兴海制药有限公司 | Health-giving oral liquor |
| CN1555884A (en) * | 2004-01-02 | 2004-12-22 | 炫 廖 | Chinese medicinal nourishing product |
| CN1660404A (en) * | 2005-01-19 | 2005-08-31 | 雷小平 | Health product of preserving health, invigorating the kidney and supporting yang for male |
| CN1706429A (en) * | 2004-06-06 | 2005-12-14 | 张玲玲 | Body-nourishing and kidney-invigorating nutritious vinegar-honey oral liquid and production process |
| CN1958039A (en) * | 2006-11-24 | 2007-05-09 | 王建兴 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases |
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2007
- 2007-12-20 CN CN2007103020435A patent/CN101461919B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244420A (en) * | 1999-02-04 | 2000-02-16 | 盘锦兴海制药有限公司 | Health-giving oral liquor |
| CN1555884A (en) * | 2004-01-02 | 2004-12-22 | 炫 廖 | Chinese medicinal nourishing product |
| CN1706429A (en) * | 2004-06-06 | 2005-12-14 | 张玲玲 | Body-nourishing and kidney-invigorating nutritious vinegar-honey oral liquid and production process |
| CN1660404A (en) * | 2005-01-19 | 2005-08-31 | 雷小平 | Health product of preserving health, invigorating the kidney and supporting yang for male |
| CN1958039A (en) * | 2006-11-24 | 2007-05-09 | 王建兴 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases |
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| CN101461919A (en) | 2009-06-24 |
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