CN101612326B - Traditional Chinese medicine for diminishing inflammation and alleviating pain and preparation method thereof - Google Patents
Traditional Chinese medicine for diminishing inflammation and alleviating pain and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for diminishing inflammation and alleviating pain and a preparation method thereof. In the invention, the preparation method comprises the following steps: fresh tall gastrodia tuber, uncaria stem with hooks, fleabane, rhizoma ligustici wallichii, imitated wildness and artificially planted dendrobium nobile, dahurian angelica root, radix puerariae, radix bupleuri and eucommia bark are adopted as raw materials, wherein the rhizoma ligustici wallichii, the dahurian angelica root, the radix bupleuri and the eucommia bark are pulverized into fine powder for standby use; the fresh tall gastrodia tuber is squeezed and filtered to obtain juice, and the juice is dried by spraying and sieved to obtain a tall gastrodia tuber extract; the uncaria stem with hooks, the fleabane, the dendrobium nobile and the radix puerariae are heated, recirculated and extracted by ethanol, extracting liquid is merged, the ethanol is recovered for standby until no alcohol smell emerges, and residues are added with water, decocted once, filtered, merged with the extracting liquid, concentrated, dried by spraying and sieved to obtain dry paste powder after the ethanol is extracted; and the rhizoma ligustici wallichii, the dahurian angelica root, the radix bupleuri, the eucommia bark fine powder and the tall gastrodia tuber extract are added, evenly mixed and filled into capsules to prepare capsules for diminishing inflammation and alleviating pain. The invention is a pure traditional Chinese medicine preparation, has the curative effects of diminishing inflammation and alleviating pain, is safe and innoxious when being taken, has no dependence and addiction and treats the superficiality and origin of a disease.
Description
Technical field
The present invention relates to a kind of anti-inflammatory analgetic Chinese medicine and preparation method thereof, belong to field of pharmaceutical technology.
Background technology
Chinese medicine is the traditional medicine of China, aspect prevention and treatment of diseases, made huge contribution for the mankind, no exception on pain therapy, the folk prescription or the compound preparation that have many Chinese medicines to make all have good anti-inflammatory analgetic effect, and side effect is little or have no side effect, can treating both the principal and secondary aspects of a disease.Therefore based on Chinese medical theory, further research and development are just quite meaningful based on the anti-inflammation analgesic of Chinese medicine.
The traditional Chinese medical science thinks, having a headache is the ailment said due to cold or exposure invasion and attack, on violate top, mountain peak channels, disharmony between QI and blood, meridians check, then channels stays the stasis of blood for a long time, and is every because of the weather cataclysm, or idol suffers ailment said due to cold or exposure and shows effect; Liver property happiness bar reaches, and the Yu Ze stagnation of QI is not smooth, as because of the excitement of feelings will, then the wind of liver and gall follow through and on, also the stasis of blood can cause headache; Also have because of the natural endowment weakness, vim and vigour are plain loses, and the brain vital essence is not filled, and is every because of hardworking or the brain overwork person of causing; Or because of tumbling down clashes into, undermines brain, so that the blood stasis stagnation, the network road is obstructed, and the person is not reported in the headache delay repeatedly.
Neuropathic pain is meant by central or peripheral nervous system constitutional pathological changes or dysfunction and the pain syndrome that causes.Can be by wound or/and disease cause behind peripheral nerve, the spinal cord root, spinal cord and some position damage of above nervus centralis thereof and cause.
Hypochondriac pain serves as the pain of main performance with one or both sides side of body flank pain.Hypochondriac pain is generally in the exopathogen and invades, and is many with damp and hot heresy especially; Or feelings will hinders, and shows as depressed emotion; Or the rage impairing the liver, to depression of liver-QI; Or eating and drinking without temperance, the surfeit delicious food is made humidogene heat, pents up liver and gall; Or tumbling down damage, the powerful heavy burden is at a stop blood stasis and falls ill; Or labor desires prolonged illness, or innate deficiency, deficiency and exhaustion of liver-YIN, and venation is lost and reason such as is supported and cause.
Toothache is a kind of commonly encountered diseases.Carry according to " Waike Zhengzong, Orthodox Manual of External Diseases ": " the tooth patient has wind, and fire is arranged, and also has sun bright damp and hot, all can cause it.Wind pain person meets wind outbreak edema, gives birth to pain subsequently, controls it with XIAOFENG SAN." carry according to " dialectical record ": " people has toothache very can not bear, and tears all do not go out the person, and this is that fire in ZANG FU-organs is prosperous, uply has a pain also in tooth." carry according to " dialectical record ": " people has tooth pain, to night and very, the groan person that do not crouch, with event of kidney fire upper punch also, the fiery upper punch of right kidney, non-excess-fire is also." illustrating and have a toothache and can attack that injure tooth body and gingiva meat, evil poly-diffusing, QI and blood is detained by wind heat, the stasis of blood hinders venation and is disease; Or steam on the stomach-fire, it is pungent to have a liking for food again, or wind-heat evil toxin violates outward, and the priming stomach-fire is followed through last steaming dental bed, injures gum meat, undermines venation and is disease; Or damage of kidney-YIN, hyperactivity of deficient fire causes luxated tooth and reasons such as pain cause.
Osteodynia is common chronic joint disease, and the exopathogenic factor of morbidity mostly is injury and bone fracture, knee joint foot deformity, factors such as scoliosis; Endogenous cause of ill is a wind-cold damp pathogen, blocks meridians, due to the caused by liver and kidney deficiency, qi stagnation blood stasis.
Angina pectoris is meant because the temporary transient ischemia of cardiac muscle, the anoxia due to the coronary insufficiency, and the paroxysmal chest pain is anginal main clinical manifestation.Control according to the dialectical opinion of motherland's medical science and to adopt two ruling by law that take stopgap measures and effect a permanent cure to treat angina pectoriss.Take stopgap measures, mainly use, based on " leading to ", invigorate blood circulation, blood stasis dispelling, method such as regulate the flow of vital energy, activate yang, reduce phlegm in the pain phase; Effect a permanent cure, generally use, based on regulating YIN and YANG, internal organs, QI and blood, YANG invigorating, YIN nourishing arranged, fill blood, method such as conditioning viscera in the catabasis.
Dysmenorrhea is the commonly encountered diseases of gynecological, is that periodically lower abdomen pain appears in the women on the occasion of menstrual period or before and after passing through, or draws the waist sacrum bitterly, and very then severe pain faintness person is called dysmenorrhea, also claims abdominal pain during menstruation.Dysmenorrhea morbidity is mainly hindered by feelings will, and the careless or six climate exopathogens of daily life etc. cause, and and physical factors, the special internal milieu in menstrual period and front and back thereof has certain relation.Its pathogenesis mainly influences because of being subjected to above-mentioned paathogenic factor menstrual period, causes dashing and appoints QI-blood circulation not smooth, and the uterus menses are obstructed, so that stagnation of QI and blood may bring about pain, or dashes and appoint a uterus to lose the pain in moistening foster and not flourish.
The pain that wound is followed is acute pain before wound is recovered, pain also often relatively acutely, acute pain can be alleviated and is chronic pain after wound healing.Pain is one of topmost symptom of wound, and the control of pain directly has influence on the prognosis of wound.
Inflammation, the biological tissue with vascular system is an inflammation to the defense reaction that damage factor took place, and is body for a kind of defense reaction that stimulates, and shows as red, swollen, hot, bitterly and dysfunction.
The performance of each Chinese medicine:
Rhizoma Gastrodiae: the dry tuber of orchid Rhizoma Gastrodiae, the beginning is stated from Shennong's Herbal, classifies as top grade.Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] are sweet, flat for Rhizoma Gastrodiae.Return Liver Channel.[function with cure mainly] suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.It is dizzy to be used to have a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus "." Chinese materia medica " according to Gao Xuemin chief editor carries: " Rhizoma Gastrodiae had both ceased liver-wind, suppressing the hyperactive liver sun again, the key medicine of, headache dizzy for controlling ".Show that according to modern study Rhizoma Gastrodiae is rich in gastrodine, phenoloid, gastrodia elata polysaccharide, several amino acids, micro-alkaloid, various trace elements etc. are to human body beneficial's active component.With electric shock Mus tail method, prove that artificial culture Rhizoma Gastrodiae and Wild gastrodia all have very significant analgesia role; There are analgesic activity in gastrodin derivant acegastrodine and gastrodin unit to mice.The Rhizoma Gastrodiae injection all has inhibitory action to oozing out with swelling of multiple inflammation, and can suppress acetic acid induced mice abdominal cavity hair and blood pipe permeability increases, and can suppress ear's swelling of dimethylbenzene induced mice and permeability increases; And can suppress 5-HT, PGE
2Due to the rat skin capillary permeability increase.Artificial gastrodia cultivation, general Rhizoma Gastrodiae and increase the zinc Rhizoma Gastrodiae mice is all had antiinflammatory action.According to another clinical report, Rhizoma Gastrodiae also is used for the treatment of the neurasthenia, vertigo, neuropathic pain, postcerebrotraumatic syndrome, facial spasm disease, arthromyodynia, lumbago and skelalgia etc.
Ramulus Uncariae Cum Uncis: the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, Ramulus Uncariae Cum Uncis, Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis.Beginning is stated from " Mingyi Bielu ", and the successive dynasties book on Chinese herbal medicine all records.Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] are sweet, cold for Ramulus Uncariae Cum Uncis.Return liver, pericardium channel.[function with cure mainly] heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.It is dizzy to be used to have a headache, dysphoric cold, and infantile convulsion is twitched, pregnant eclamposia; Hypertension "." Chinese materia medica " according to Gao Xuemin chief editor carries: and Ramulus Uncariae Cum Uncis " can removing heat from the liver, again can the suppressing the hyperactive liver sun, so attack or the feeling of fullness in the head headache of excessive rising of liver-YANG dizzy disease such as grade on the available treating the liver fire ".Show that according to modern study Ramulus Uncariae Cum Uncis mainly contains Ramulus Uncariae cum Uncis alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, flavone compound, catechin compounds, tannin and terpenoid etc. are to human body beneficial's active component.According to clinical report, Ramulus Uncariae Cum Uncis can be used for treating migraine, vertigo, hypertension etc.
Herba Erigerontis (Herba Erigerontis): be the dry herb of feverfew Erigeron breviscapus (Vant.) Hand.-Mazz., former is that ethnic groups such as Yunnan Miao ethnic group among the people, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, De'ang nationality are commonly used medical herbs.The Herba Erigerontis beginning is stated from " the southern regions of the Yunnan Province book on Chinese herbal medicine ", and its nature and flavor, effect have been done corresponding record: " bitter in the mouth, suffering, warm in nature.Children's's glue ear is smash juice and is splashed in ear; The paralysed right paralysis in a left side, rheumatalgia, the decocting or the clothes of steeping in wine ".Carry according to " China's book on Chinese herbal medicine ": Herba Erigerontis " acrid in the mouth, little hardship, temperature.Return lung, stomach, Liver Channel ....Expelling cold and relieving exterior syndrome, expelling wind and removing dampness, activating collaterals to relieve pain, removing food stagnancy.Cure mainly flu, rheumatic arthralgia, paralysis, stomachache, toothache, infantile malnutrition, osteomyelitis, traumatic injury ".Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: Herba Erigerontis " [nature and flavor with return through] hot, little hardship, temperature.GUIXIN, Liver Channel.[function with cure mainly] expelling wind and cold, promoting blood circulation, dredging meridian and relieving pain.Be used for rheumatism numbness pain, paralysis due to windstroke, obstruction of qi in the chest and cardialgia.Toothache, flu ".Show that according to modern study Herba Erigerontis is rich in effective active compositions such as sterols composition, flavones ingredient, paralysis, coronary heart disease, angina pectoris and rheumatism that the occlusive cerebral thrombosis is caused have better curative effect.
Rhizoma Chuanxiong: the dry rhizome of samphire Rhizoma Chuanxiong, the beginning is stated from Shennong's Herbal, classifies as top gradely, and the successive dynasties book on Chinese herbal medicine is all on the books.Original name vault labor.Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] suffering, temperature.Return liver, gallbladder, pericardium channel.[function with cure mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia ".Carry according to Shennong's Herbal: " main apoplexy is gone into brain for rhizome of chuanxiong, acrid in the mouth temperature, headache, and arthralgia due to cold, the clonic spasm of the muscle emergency, the gold wound, married woman's blood closes loss of fecundity ".Carry according to " Treatise on the spleen and stomach ": " headache must be used Rhizoma Chuanxiong "." Chinese materia medica " according to the Gao Xuemin chief editor carries: and Rhizoma Chuanxiong " Xin Xiangsheng looses, the up head of energy, and wind-expelling pain-stopping is for controlling the headache key medicine.Forefathers have: the saying of ' headache not from Rhizoma Chuanxiong '.It controls headache, and no matter wind and cold, wind heat, rheumatism, blood deficiency, blood stasis all can be used it with the card compatibility.... the available again tooth pain of controlling ".Show that according to modern study Rhizoma Chuanxiong is rich in chemical constituents such as phthalide derivant, two phthalide derivant, alkaloid, organic acid and organic acid ester.The in vitro tests Rhizoma Chuanxiong has obvious inhibitory action to large intestine, dysentery, distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Clinically be used to prevent and treat migraine, lose dizzy disease etc. after treatment cardiovascular disease, dizzy, hypertension and the cerebral concussion.
Dendrobium nobile: the beginning is stated from Shennong's Herbal, classifies as top gradely, and the successive dynasties book on Chinese herbal medicine is all on the books.The Shennong's Herbal record: " ... sweet in the mouth, flat, nontoxic.In curing the wound, eliminating impediment, the therapeutic method to keep the adverse QI flowing downwards, the tonifying five ZANG-organs asthenia, win thin, reinforcing YIN-essence.The thick the intestines and stomach of clothes is made light of one's life by commiting suicide for a long time, prolong life, and longue meat, by skin pathogenic heat ， Rush gas, sedate removes frightened ... ".Supplementary Amplifications of the Compendium of Materia Medica (clear ZHAO Xue-Min): " clearing stomach removes deficiency-heat, promotes the production of body fluid, strain, with for tea, appetite promoting and the spleen strengthening, wind is treated in arresting convulsion, can press down saliva expectorant, expelling summer-heat, sweet fragrant sending down the abnormal ascending QI ".Herba Dendrobii that this product adopts is the dry stem of orchid Dendrobium nobile Dendrobium nobile lindl.; Be " first-selected kind under Herba Dendrobii item of Chinese pharmacopoeia (version in 2005).Dendrobium nobile: one one of the Pharmacopoeia of the People's Republic of China (version in 2005) carries:
[nature and flavor with return through] hardship is slightly cold.Return stomach, kidney channel.
[function with cure mainly] reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Be used for cloudy impairment of body fluid and lose, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Dendrobium nobile grows on height above sea level 590～3000 meters original remote mountains woods or the crag.Its main functional component is: dendrobium polysaccharide and Herba Dendrobii alkaloids.Herba Dendrobii alkaloids main component has dendrobine (dendrobine), Herba Dendrobii time alkali (nobilonine), Herba Dendrobii ether alkali (dendroxine), 6-hydroxyl Herba Dendrobii ether alkali, 4-hydroxyl Herba Dendrobii ether alkali and methine Herba Dendrobii element (nobilimethylene) etc.Wherein dendrobium polysaccharide is the roborant main component of Herba Dendrobii, energy enhancing human body immunity function, and have anti-tumor activity; The pharmacological action of dendrobine mainly shows antitumor, to cardiovascular, gastrointestinal tract inhibitory action and pain relieving antipyretic effect.The internal heat of deficiency of yang of the traditional Chinese medical science is because Na
+-K
+A kind of performance that-atpase activity is too high, Herba Dendrobii can suppress kidney microsome Na
+-K
+The pharmacological action of-atpase activity and the effect of its nourishing YIN and clearing away heat are corresponding to.
The Radix Angelicae Dahuricae: the dry root of the samphire Radix Angelicae Dahuricae or Radix angelicae dahuricae, the beginning is stated from Shennong's Herbal, classifies middle product as, and the successive dynasties book on Chinese herbal medicine is all on the books.Carry according to " book on Chinese herbal medicine converge with speech ": " Radix Angelicae Dahuricae, the up head support the intestines and stomach down, in reach limbs, so that a hair key, and profit is let out pathogen all over logical skin.As wind syndrome of head headache, dizzy blurred vision; As extremity fiber crops pain, flaccidity of the lower limbs flaccidity syndrome and arthralgia syndrome; It is rotten to the corn to burst as skin ulcer, and evacuation of pus is put on flesh; Hinder as two orders, sufferings are red puckery; Close as woman's blood, swelling of the vulva leaks band; As children's's variola, make slurry and have an itch, the Radix Angelicae Dahuricae all can be controlled it ".Carry according to " book on Chinese herbal medicine is looked for the truth ": " Radix Angelicae Dahuricae, temperature power is thick, and sensible row table is the medicine of sufficient Yangming Channel expelling pathogenic wind and eliminating dampness.So all diseases of energy all women's head-ornaments of Zhi Yangming, as head's dusk pain, supraorbital bone pain, and gingiva osteodynia, dark complexion scar defect person is also ".Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] suffering, temperature.Return stomach, large intestine, lung meridian.[function with cure mainly] the wind dehumidifying of loosing, understand things pain-stopping, detumescence and apocenosis.Be used for headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache ".Show that according to modern study the Radix Angelicae Dahuricae contains effective active compositions such as Coumarins composition, volatile ingredient.Be used for the treatment of headache clinically, stomachache, arthralgia, rhinitis, sinusitis, infectious purulent disease etc.
The Cortex Eucommiae: the dry bark of the Eucommiaceae plant Cortex Eucommiae.Carry according to Shennong's Herbal: the Cortex Eucommiae " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, strong will, wet except that itching under cloudy, dribbling urination.Obey for a long time, it is anti-old to make light of one's life by commiting suicide ".Carry according to " Mingyi Bielu ": the Cortex Eucommiae " is controlled in the foot and is ached, do not desire to trample ground ".Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] are sweet, temperature for the Cortex Eucommiae.Return liver, kidney channel.[function with cure mainly] invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension ".Show that according to modern study the Cortex Eucommiae contains effective active compositions such as lignanoid, iridoid constituents, organic acid.Cortex Eucommiae injection can alleviate the rat paw edema due to the Ovum Gallus domesticus album, suppresses acetic acid induced mice abdominal cavity capillary permeability and increases.Cortex Eucommiae decoct is external to have bacteriostasis in various degree to multiple pathogenic bacterias such as staphylococcus aureus, escherichia coli, anthrax bacillus, streptococcus pneumoniae.The Cortex Eucommiae can also be treated sciatica.
Radix Puerariae: the dry root of legume pueraria lobata.Carry according to " Mingyi Bielu ": Radix Puerariae " the excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles is delivered, and perspires loosing the interspaces of skin and muscles ".Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] are sweet, hot, cold for Radix Puerariae.Return spleen, stomach warp.[function with cure mainly] expelling pathogenic factors from muscles for reducing heat promotes the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea is had loose bowels; Hypertension neck pain ".Show that according to modern study Radix Puerariae contains effective active compositions such as flavone compound, phenoloid, tryptophan derivative and glucoside thereof.Be used for the treatment of headache, sciatica, cervical spondylosis, typhoid fever, chronic non-specific ulcerative colitis, chronic bronchitis, hypertension, coronary heart disease etc. clinically.
Radix Bupleuri: the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Carry according to " medicine justice ": " Radix Bupleuri, property is gently clear, and main the liter loose, mildly bitter flavor, the main evacuation ....All three warmers gallbladder-heat, or migraine, or the living skin ulcer of in ear, or hectic fever gallbladder numbness, or stabbing hypochondrium pain are loose with the gas of soothing the liver gallbladder with the Radix Bupleuri liver heat removing, and all diseases are known more ".Carry according to one one of Pharmacopoeia of the People's Republic of China version in 2005: " [nature and flavor with return through] hardship is slightly cold Radix Bupleuri.Return liver, gallbladder meridian.[function with cure mainly] reconciling superficies and interior, soothing the liver, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia; Uterine prolapse, proctoptosis ".Show that according to modern study Radix Bupleuri mainly contains effective active compositions such as volatile oil, Saponin, organic acid.Be used for the treatment of secretory otitis media, allergic rhinitis, mumps, adult's chronic nephritis, viral hepatitis, oromaxillo-facial region acute inflammation etc. clinically.
Summary of the invention
Technical problem to be solved by this invention provides a kind of anti-inflammatory analgetic Chinese medicine and preparation method thereof, this anti-inflammation analgesic makes full use of the Chinese crude drug that tradition has anti-inflammatory analgetic, prescription is rationally taken safety non-toxic, has antiinflammatory, invigorates blood circulation, the meridian dredging, dredges breath wind, analgesic effect.Its preparation method is scientific and reasonable, can give full play to raw materials used characteristic, and pain such as neuropathic pain, migraine, hypochondriac pain, toothache, osteodynia, angina pectoris, dysmenorrhea, treatment of traumatic pain are had significant curative effect.
Solving the technical scheme that technical problem of the present invention adopts is:
To produce 1000, it adopts following proportion raw material to make: fresh gastrodia elata 1408g, Ramulus Uncariae Cum Uncis 86g, Herba Erigerontis 82g, Rhizoma Chuanxiong 62g, Dendrobium nobile 120g, Radix Angelicae Dahuricae 41g, Cortex Eucommiae 86g, Radix Puerariae 26g, Radix Bupleuri 28g.
The preparation process of acesodyne capsule of the present invention is:
1. an amount of Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae pulverize separately are become granularity 〉=80 order fine powders, standby;
2. with the proper amount of fresh Rhizoma Gastrodiae through transmission from one meridian to another fragmentation, filter pressing, cross 100 mesh filter screens, Rhizoma Gastrodiae juice, spray drying is crossed 100 mesh sieves, Rhizoma Gastrodiae extract;
3. an amount of Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, Radix Puerariae are extracted 2 times with 65%～90% alcohol heating reflux, each 3 hours, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor, and was standby; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the Radix Puerariae residue behind ethanol extraction decocts with water once again, filters, and merges with said extracted liquid, concentrates, and spray drying is crossed 100 mesh sieves, and powder gets dry extract.Add Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae fine powder and Rhizoma Gastrodiae extract, mix homogeneously incapsulates, and makes 1000, promptly.
Anti-inflammatory analgetic preparation method of Chinese medicine of the present invention comprises:
1. the raw material fresh gastrodia elata adopts zone, township, Zhaotong City Caulis et Folium Polygalae Tenuifoliae dam, Yunnan Province, and height above sea level is at the Rhizoma Gastrodiae of 1400～2800 meters growths, and the collecting time of fresh gastrodia elata is annual 20 February 20 to next year of December; The raw material Dendrobium nobile adopts the high-quality Dendrobium nobile of imitative wild artificial growth under virgin forest;
2. raw material Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the relative density of the extracting solution of Radix Puerariae through obtaining behind ethanol and the water extraction after concentrating are controlled to be 1.05～1.15, and spray-dired inlet temperature is 120 ± 5 ℃, and leaving air temp is 70 ± 5 ℃; Relative density before the Rhizoma Gastrodiae juice drying is controlled to be 1.08～1.14, and spray-dired inlet temperature is 100 ± 5 ℃, and leaving air temp is 75 ± 5 ℃, and temperature is in 96 ℃ in the tower wall of equipment;
3. fresh gastrodia elata remains on before processing≤21 ℃ temperature;
4. to extract the time of being processed into powder from be unearthed to squeezing the juice be in 8 hours to fresh gastrodia elata;
5. fresh gastrodia elata is processed into the process of powder from cleaning to extract, and being exposed to the airborne time should be in 6 hour;
6. fresh gastrodia elata process time of squeezing the juice should be in 2 hours;
7. the juice that obtains after fresh gastrodia elata is squeezed the juice is exposed to the airborne time should be in 30 minutes.
Compatibility of the present invention is according to being: Rhizoma Gastrodiae is sweet, and is flat.Return Liver Channel.The suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.It is dizzy to be used to have a headache, epilepsy clonus.Ramulus Uncariae Cum Uncis is sweet, cold.Return liver, pericardium channel.The heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.It is dizzy to be used to have a headache, and infantile convulsion is twitched.Herba Erigerontis, little hardship, temperature.GUIXIN, Liver Channel.Expelling wind and cold, promoting blood circulation, dredging meridian and relieving pain.Be used for rheumatism numbness pain, paralysis due to windstroke, obstruction of qi in the chest and cardialgia, toothache.The Rhizoma Chuanxiong suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for headache, rheumatic arthralgia.The Dendrobium nobile sweet in the mouth nourishes, and it is refrigerant to be slightly cold, and energy tonifying five ZANG-organs asthenia is won thin, the characteristic of tool dredging the meridian QI and blood, clearing away heat to alleviate pain.Radix Angelicae Dahuricae suffering, temperature.Return stomach, large intestine, lung meridian.The wind that looses dehumidifies understand things pain-stopping.Be used for headache due to common cold, toothache.Radix Puerariae is sweet, hot, cold.Return spleen, stomach warp.Be used for the fever caused by exogenous pathogens headache, stiff nape and back.The Radix Bupleuri hardship is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.The Cortex Eucommiae is sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Full side's compatibility is a monarch drug with the Rhizoma Gastrodiae, the suppressing the hyperactive liver sun, and sedation-analgesia helps dredging the meridian, and its main component Gastrodine and aglycon thereof have analgesic activity, and its preparation all has inhibitory action to oozing out with swelling of multiple inflammation; Ramulus Uncariae Cum Uncis, Herba Erigerontis dispelling wind and relieving convulsion, promoting blood circulation, dredging meridian and relieving pain; The up head of Rhizoma Chuanxiong, the descending sea of blood, can blood circulation promoting and blood stasis dispelling again can the circulation of qi promoting wind-expelling pain-stopping; Radix Puerariae, its gas of Radix Bupleuri lightly float to rise and loose; Dendrobium nobile, Cortex Eucommiae the liver and the kidney tonifying ask nourishing to effect a permanent cure; Radix Angelicae Dahuricae Zhi Yangmingzhu pain is drawn top, the up mountain peak of all medicines.All medicines match, regulating qi and dredging collateral, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, general rule not bitterly, the liver and the kidney tonifying, the internal organs meridians that make moist reach the merit for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows:
1. based on Chinese medical theory, the pure Chinese medicine anti-inflammatory analgetic preparation of researching and developing out.
2. prescription is reasonable, and treating both the principal and secondary aspects of a disease also has comprehensive opsonic action to human body, helps patient's rehabilitation.
3. taking convenience is evident in efficacy, has no side effect, and does not have addiction and dependency, does not develop immunity to drugs.
4. preparation method is scientific and reasonable, is suitable for industrialized development.
The specific embodiment
Embodiment 1:
[prescription] fresh gastrodia elata 1408g, Ramulus Uncariae Cum Uncis 86g, Herba Erigerontis 82g, Rhizoma Chuanxiong 62g, Dendrobium nobile 120g, Radix Angelicae Dahuricae 41g, Cortex Eucommiae 86g, Radix Puerariae 26g, Radix Bupleuri 28g
[preparation method] above nine flavors, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae pulverize separately become fine powder, and be standby; Fresh gastrodia elata is crossed 100 mesh filter screens through squeezing the juice, and gets Rhizoma Gastrodiae juice, and spray drying is crossed 100 mesh sieves, gets Rhizoma Gastrodiae extract; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, Radix Puerariae extract 2 times with 80% alcohol heating reflux, and each 3 hours, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor, and was standby; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the Radix Puerariae residue behind ethanol extraction decocts with water once again, filters, and merges with said extracted liquid, concentrates, and spray drying is crossed 100 mesh sieves, and powder gets dry extract.Add Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae fine powder and Rhizoma Gastrodiae extract, mixing incapsulates, and makes 1000, promptly.
Embodiment 2:
[prescription] fresh gastrodia elata 1408g, Ramulus Uncariae Cum Uncis 86g, Herba Erigerontis 82g, Rhizoma Chuanxiong 62g, Dendrobium nobile 120g, Radix Angelicae Dahuricae 41g, Cortex Eucommiae 86g, Radix Puerariae 26g, Radix Bupleuri 28g
[preparation method] above nine flavors, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae pulverize separately become fine powder, and be standby; Fresh gastrodia elata is crossed 100 mesh filter screens through squeezing the juice, and gets Rhizoma Gastrodiae juice, and spray drying is crossed 80 mesh sieves, gets Rhizoma Gastrodiae extract; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, Radix Puerariae extract 2 times with 65% alcohol heating reflux, and each 3 hours, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor, and was standby; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the Radix Puerariae residue behind ethanol extraction decocts with water once again, filters, and merges with said extracted liquid, concentrates, and spray drying is crossed 100 mesh sieves, and powder gets dry extract.Add Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae fine powder and Rhizoma Gastrodiae extract, mixing incapsulates, and makes 1000, promptly.
Embodiment 3:
[prescription] fresh gastrodia elata 1408g, Ramulus Uncariae Cum Uncis 86g, Herba Erigerontis 82g, Rhizoma Chuanxiong 62g, Dendrobium nobile 120g, Radix Angelicae Dahuricae 41g, Cortex Eucommiae 86g, Radix Puerariae 26g, Radix Bupleuri 28g
[preparation method] above nine flavors, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae pulverize separately become fine powder, and be standby; Fresh gastrodia elata is crossed 100 mesh filter screens through squeezing the juice, and gets Rhizoma Gastrodiae juice, and spray drying is crossed 100 mesh sieves, gets Rhizoma Gastrodiae extract; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, Radix Puerariae extract 2 times with 90% alcohol heating reflux, and each 3 hours, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor, and was standby; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the Radix Puerariae residue behind ethanol extraction decocts with water once again, filters, and merges with said extracted liquid, concentrates, and spray drying is crossed 100 mesh sieves, and powder gets dry extract.Add Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae fine powder and Rhizoma Gastrodiae extract, mixing incapsulates, and makes 1000, promptly.
Result of the test of the present invention:
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make to behind the mouse stomach, does not see that animal has poisoning symptom with maximum dosage-feeding 15000mg/kgBM, no animal dead, and animal, gross examination of skeletal muscle no abnormality seen are dissected in off-test.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 41 routine migraine patients.
Curative effect determinate standard:
(1) produce effects: headache alleviated with interior at 8 minutes after the medication, all disappeared in 15 minutes, and was not recurring more than 3 hours.
(2) take a turn for the better: headache alleviated in 9-15 minute after the medication, disappeared in 16-30 minute, and was not recurring more than 2 hours.
(3) effective: headache alleviated more than 16 minutes after the medication, was disappearing more than 31 minutes, and was not recurring more than 1 hour.
(4) invalid: the no any variation of headache after the medication.
3 conditions must possess in the above standard, and 1 does not meet and then presses primary standard successively and handle.
Therapeutic outcome: by having observed migraineur's 41 examples, 23 examples are organized in treatment, matched group 18 examples.By migrainous curative effect, attack times, duration of seizure etc. are carried out the comprehensive therapeutic effect evaluation, the result shows that the treatment group is better than matched group, and the effective percentage of treatment group reaches 91.67%, and obvious effective rate reaches 80.77%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 48 routine neuropathic pain patients.Effective percentage of the present invention reaches 98.36%, and obvious effective rate reaches 92.83%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 28 routine hypochondriac pain patients.Effective percentage of the present invention reaches 86.81%, and obvious effective rate reaches 77.62%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 26 example toothache patients.Effective percentage of the present invention reaches 71%, and obvious effective rate reaches 62.11%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 30 routine osteodynia patients.Effective percentage of the present invention reaches 89%, and obvious effective rate reaches 78.28%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 40 routine angina pectoris patients.Effective percentage of the present invention reaches 81.84%, and obvious effective rate reaches 73.27%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 20 routine dysmenorrhea pain patients.Effective percentage of the present invention reaches 78.22%, and obvious effective rate reaches 61.91%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 26 routine treatment of traumatic pain patients.Effective percentage of the present invention reaches 69%, and obvious effective rate reaches 57.31%, and does not have any untoward reaction.
The anti-inflammatory and analgesic capsule that adopts the foregoing description 1 to make is by treating observation to 35 routine inflammation patients.Effective percentage of the present invention reaches 68.11%, and obvious effective rate reaches 51.84%, and does not have any untoward reaction.
Claims (9)
1. anti-inflammatory analgetic Chinese medicine, it is characterized in that: to produce 1000, it adopts following proportion raw material to make: fresh gastrodia elata 1408g, Ramulus Uncariae Cum Uncis 86g, Herba Erigerontis 82g, Rhizoma Chuanxiong 62g, Dendrobium nobile 120g, Radix Angelicae Dahuricae 41g, Cortex Eucommiae 86g, Radix Puerariae 26g, Radix Bupleuri 28g.
2. anti-inflammatory analgetic Chinese medicine according to claim 1 is characterized in that: what following raw material Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile and Radix Puerariae adopted is the extract powder; All the other raw materials are the former medicine fine powders of granularity 〉=80 purposes, and mixed together evenly becomes capsule preparations.
3. described anti-inflammatory analgetic preparation method of Chinese medicine of claim 1, its feature comprises following steps:
1. with Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, the Cortex Eucommiae pulverize separately of described proportioning, its granularity 〉=80 orders;
2. fresh gastrodia elata extracts: the fresh gastrodia elata of getting described proportioning obtains Rhizoma Gastrodiae juice through fragmentation, filter pressing, filtration, and is spray-dried again, obtains Rhizoma Gastrodiae extract;
3. Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the Radix Puerariae with described proportioning extracts: Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, Radix Puerariae extract 2 times with 65%～90% alcohol heating reflux, and each 3 hours, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor, and was standby; Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, the Radix Puerariae residue behind ethanol extraction decocts with water once again, filters, and merges with said extracted liquid, concentrates, and spray drying is sieved, and powder gets dry extract;
4. add Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Bupleuri, Cortex Eucommiae fine powder and Rhizoma Gastrodiae extract, mix homogeneously incapsulates.
4. anti-inflammatory analgetic preparation method of Chinese medicine according to claim 3 is characterized in that:
1. the raw material fresh gastrodia elata adopts zone, township, Zhaotong City Caulis et Folium Polygalae Tenuifoliae dam, Yunnan Province, and height above sea level is at the Rhizoma Gastrodiae of 1400～2800 meters growths, and the collecting time of fresh gastrodia elata is annual 20 February 20 to next year of December; The raw material Dendrobium nobile adopts the Dendrobium nobile of imitative wild artificial growth under virgin forest;
2. raw material Ramulus Uncariae Cum Uncis, Herba Erigerontis, Dendrobium nobile, Radix Puerariae are controlled to be 1.05～1.15 through the relative density of the extracting solution that obtains behind ethanol and the water extraction after concentrating, and spray-dired inlet temperature is 120 ± 5 ℃, and leaving air temp is 70 ± 5 ℃; Relative density before the Rhizoma Gastrodiae juice spray drying is controlled to be 1.08～1.14, and spray-dired inlet temperature is 100 ± 5 ℃, and leaving air temp is 75 ± 5 ℃, and temperature is in 96 ℃ in the tower wall of equipment.
5. anti-inflammatory analgetic preparation method of Chinese medicine according to claim 3 is characterized in that: fresh gastrodia elata remains on before processing≤and 21 ℃ temperature.
6. anti-inflammatory analgetic preparation method of Chinese medicine according to claim 3 is characterized in that: fresh gastrodia elata extracts the time of being processed into powder from be unearthed to squeezing the juice be in 8 hours.
7. anti-inflammatory analgetic preparation method of Chinese medicine according to claim 3 is characterized in that: fresh gastrodia elata is processed into the process of powder from cleaning to extract, and being exposed to the airborne time should be in 6 hour.
8. anti-inflammatory analgetic preparation method of Chinese medicine according to claim 3 is characterized in that: should finish with interior the process time that fresh gastrodia elata is squeezed the juice at 2 hours.
9. anti-inflammatory analgetic preparation method of Chinese medicine according to claim 3 is characterized in that: the juice that obtains after fresh gastrodia elata is squeezed the juice is exposed to the airborne time should be in 30 minutes.
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| CN1698721A (en) * | 2005-05-14 | 2005-11-23 | 许志炎 | Headache treating Chinese medicine and its preparation method |
| CN101032604A (en) * | 2007-04-16 | 2007-09-12 | 北京艺信堂医药研究所 | Chinese medicine preparation for curing vascular type headache |
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| CN1698721A (en) * | 2005-05-14 | 2005-11-23 | 许志炎 | Headache treating Chinese medicine and its preparation method |
| CN101032604A (en) * | 2007-04-16 | 2007-09-12 | 北京艺信堂医药研究所 | Chinese medicine preparation for curing vascular type headache |
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| 徐辉.川芎定痛汤治疗偏头痛40 例.《陕西中医》.2006,第27卷(第12期), * |
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