CN105963609A - Pharmaceutical composition for treating lung pathogenic warm type bovine ephemeral fever and preparation method thereof - Google Patents

Pharmaceutical composition for treating lung pathogenic warm type bovine ephemeral fever and preparation method thereof Download PDF

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CN105963609A
CN105963609A CN201610307005.8A CN201610307005A CN105963609A CN 105963609 A CN105963609 A CN 105963609A CN 201610307005 A CN201610307005 A CN 201610307005A CN 105963609 A CN105963609 A CN 105963609A
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weight portion
herba
pharmaceutical composition
rhizoma
radix
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滕旭光
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a pharmaceutical composition for treating lung pathogenic warm type bovine ephemeral fever and a preparation method thereof. The pharmaceutical composition is prepared from the following crude drugs: lotus leaves, herba equiseti hiemalis, all-grass of Chinese aeluropus, radix isatidis, poria cocos, all-grass of polygonum hydropiper, asian butteflybush root and leaf, fruit of negundo chastetree, longan seeds, herb of siebold buttercup, roots of thorny elaeagnus, yucca gloriosa, argyreia acuta lour, neosinocalamus affinis liquid, fruit of Chinese sinopodophyllum, Indian kalimeris herb, radix astragali seu hedysari, rhizoma cibotii, fructus ligustri lucidi, rhizoma polygonati, ganodorma lucidum, fruits of herba themedae japonicae, oat grass, rhizoma alpiniae officinarum, tangerine pith and folium eriobotryae. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition has the effects of clearing away heat and eliminating dampness, relieving cough and asthma, tonifying qi and securing exterior and warming and reducing phlegm on the aspect of treating the lung pathogenic warm type bovine ephemeral fever; by scientifically regulating a base body, the pharmaceutical composition has good effect and rapid curative effect, the bovine ephemeral fever is not easy to reoccur, and the pharmaceutical composition has no toxic effect and can be used for promoting the growth of cattle.

Description

A kind for the treatment of warms the pharmaceutical composition and preparation method thereof at pulmonary type Bovine Ephemeral Fever
Technical field
The present invention relates to herbal medicine pharmaceutical technology field, warm the pharmaceutical composition and preparation method thereof at pulmonary type Bovine Ephemeral Fever particularly to a kind for the treatment of.
Background technology
Bovine Ephemeral Fever is by bovine epizootic fever virus, has another name called bovine ephemeral fever virus, a kind of acute febrile infectious disease caused.It is characterized by the highest heat, tachypnea, shed tears and Alimentary serious mucositis inflammation and the dyskinesia.The sick cattle of major part infecting this disease i.e. recovered normal through 2 days～3 days, therefore also known as Ephemeral fever or temporarily hot.This disease patient's condition is swift and violent, but mostly is optimum process.This disease is mistakenly considered influenza by past attempts.This condition of disease causes Niu great Qun to fall ill, hence it is evident that reduce the milk production of milk cattle.
Disease pathogen: bovine epizootic fever virus is sub-thread minus-stranded rna virus, belongs to Rhabdoviridae, and ephemeral fever virus belongs to.Japan separates the size average out to 140nm × 80nm of poison.The nucleic acid of virus is RNA type, to chloroform, ether sensitivity.Pyrogenic stage virus is present in the blood of disease cattle, respiratory secretions and feces.
During Separation of Bovine epizootic fever virus, being advisable with cow blood poison intracranial inoculation, suitably inoculation animal is nascent neonatal rat or hamster, when carrying out intracranial inoculation, may separate out virus.Musization virus can also grow on BEK, calf kidney and testicular cell, and BEK cell can be caused to produce pathological change.
Symptom: incubation period is 3 days～7 days.At the beginning of disease, ill domestic animal trembles, shivering, and then body temperature is increased to more than 40 DEG C, and after delaying 2 days～3 days, temperature recovery is normal.While body temperature raises, it is seen that shed tears, have water sample eye secretion, eyelid, conjunctival congestion, edema.Tachypnea, frequency of respiration is per minute up to more than 80 times, and dyspnea is suffered from poultry and emitted moans, in depressed shape.This is owing to there occurs interstitial emphysema, sometimes can be died by being choked to death.Appetite is useless absolutely, ruminates stopping.First stomach is wriggled and is stopped, and tympanites occurs or lacks moisture, and gastric content dries up.Feces is dried, sometimes dysentery.Extremities joint edema pain, sick cattle is slow-witted vertical, walks lamely, later dysstasia and lie prostrate.Pi Wen is the most whole, and particularly angle root, earflap, acra has creeping chill.It addition, visible subcutaneous emphysema under jaw.Stream nose liquid, stomatitis, significantly flows birth.Bicker has foam.Hypourocrinia, Cloudy Urine.Can miscarry when cow in calf is ill, stillborn fetus.Breast amount declines or lactogenic stops.This disease major part is optimum process, and case fatality rate is typically below 1%, and some cases for a long time because of extremities joint pain can not stand up and be eliminated.
Bovine Ephemeral Fever is divided into by Chinese medical discrimination: affection due to external wind and heat type: disease sees heating weight, and severe cold is light, and cough, dry mouth and tougue, color is micro-red, yellow and thin fur, floating and rapid pulse；Warm is at pulmonary type: disease sees the not aversion to cold that generates heat, rapid breathing, and dyspnea with rapid respiration of coughing, mouth color is scarlet, dry, rough and yellow fur, full and rapid pulse；Affection of exogenous wind-cold damp type: disease sees aversion to cold high fever, skin is lossless, and stiffness of the nape of having a headache, thirst and liking drink, extremities joint is walked lamely for a long time because of mild swelling and pain.
Western medical treatment is the most only cured the symptoms, not the disease, and cattle itself is caused certain injury by Western medicine, is unfavorable for the growth of cattle, and therefore, Chinese medicine has certain advantage.
Summary of the invention
In order to solve the problems referred to above, the invention provides a kind for the treatment of and warm the pharmaceutical composition and preparation method thereof at pulmonary type Bovine Ephemeral Fever.
nullIn order to realize foregoing invention purpose，The invention provides a kind for the treatment of and warm the pharmaceutical composition at pulmonary type Bovine Ephemeral Fever，Wherein，Prepared by the raw medicinal material of following mass fraction: Folium Nelumbinis 10-15 weight portion、Herba Equiseti Hiemalis's 8-12 weight portion、Herba Aeluropi sinensis 12-20 weight portion、Radix Isatidis 10-20 weight portion、Rhizoma Smilacis Glabrae 8-15 weight portion、Herba Polygoni hydropiperis 12-20 weight portion、Radix seu Caulis Buddlejae Asiaticae 2-4 weight portion、Fructus Viticis Cannabifoliae 8-15 weight portion、Seed of Arillus Longan 5-10 weight portion、Folium rhoeinis 10-15 weight portion、Radix Elaeagni 4-9 weight portion、Yucca gloriosa L. 10-15 weight portion、Cortex Hibisci 8-12 weight portion、Cizu drip 7-13 weight portion、Fructus podophylli emodi 1-3 weight portion、Herba Kalimeridis 8-12 weight portion、Radix Astragali 10-20 weight portion、Rhizoma Cibotii 8-13 weight portion、Fructus Ligustri Lucidi 10-15 weight portion、Rhizoma Polygonati 8-13 weight portion、Ganoderma 6-12 weight portion、Herba Themedae japonicae fruit 10-20 weight portion、Herba avenae fatuae 12-23 weight portion、Rhizoma Alpiniae Officinarum 6-12 weight portion、Vascular aurantii 8-13 weight portion and Folium Eriobotryae 10-20 weight portion.
Wherein, the raw medicinal material having following mass fraction prepares: Folium Nelumbinis 12 weight portion, Herba Equiseti Hiemalis 10 weight portion, Herba Aeluropi sinensis 16 weight portion, Radix Isatidis 15 weight portion, Rhizoma Smilacis Glabrae 12 weight portion, Herba Polygoni hydropiperis 17 weight portion, Radix seu Caulis Buddlejae Asiaticae 3 weight portion, Fructus Viticis Cannabifoliae 12 weight portion, seed of Arillus Longan 8 weight portion, Folium rhoeinis 12 weight portion, Radix Elaeagni 8 weight portion, Yucca gloriosa L. 12 weight portion, Cortex Hibisci 10 weight portion, cizu drips 10 weight portions, Fructus podophylli emodi 2 weight portion, Herba Kalimeridis 10 weight portion, the Radix Astragali 15 weight portion, Rhizoma Cibotii 10 weight portion, Fructus Ligustri Lucidi 12 weight portion, Rhizoma Polygonati 10 weight portion, Ganoderma 8 weight portion, Herba Themedae japonicae fruit 16 weight portions, Herba avenae fatuae 18 weight portion, Rhizoma Alpiniae Officinarum 10 weight portion, Vascular aurantii 10 weight portion and Folium Eriobotryae 16 weight portion.
In order to achieve the above object, present invention also offers described treatment warm to comprise the following steps in the preparation method of the pharmaceutical composition of pulmonary type Bovine Ephemeral Fever:
The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the ethanol that determining alcohol is 80～90% of 4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 350 mesh～the micropowders of 400 mesh；
3rd step, the micropowders that second step is obtained, add relative to its quality 0.1～the microcrystalline Cellulose of 0.2 times, 0.05～0.2 times of lactose, starch of 0.1～0.2 times, sieve, mix homogeneously, pelletize, it is dried, adds relative to micropowders quality 0.005～0.02 times of magnesium stearate, granulate, tabletting, makes.
The invention has the beneficial effects as follows: the pharmaceutical composition of the present invention, treatment warm is at pulmonary type Bovine Ephemeral Fever, there is effect that clearing away heat and eliminating dampness, relieving cough and asthma, invigorating QI to consolidate the body surface resistance and warm are reduced phlegm, by the science of matrix is nursed one's health, effective, curative effect is fast, is difficult to recurrence, and have no side effect, and promote the growth of cattle.
Detailed description of the invention
The present invention provides a kind for the treatment of to warm the pharmaceutical composition at pulmonary type Bovine Ephemeral Fever, wherein, including following raw medicinal material: Folium Nelumbinis, Herba Equiseti Hiemalis, Herba Aeluropi sinensis, Radix Isatidis, Rhizoma Smilacis Glabrae, Herba Polygoni hydropiperis, Radix seu Caulis Buddlejae Asiaticae, Fructus Viticis Cannabifoliae, seed of Arillus Longan, Folium rhoeinis, Radix Elaeagni, Yucca gloriosa L., Cortex Hibisci, cizu drip, Fructus podophylli emodi, Herba Kalimeridis, the Radix Astragali, Rhizoma Cibotii, Fructus Ligustri Lucidi, Rhizoma Polygonati, Ganoderma, Herba Themedae japonicae fruit, Herba avenae fatuae, Rhizoma Alpiniae Officinarum, Vascular aurantii and Folium Eriobotryae.Ingredients scientific matching, reaches treatment and warms the purpose at pulmonary type Bovine Ephemeral Fever, have preferable effect.
The pharmacology of various raw medicinal materials is as follows:
Folium Nelumbinis: [nature and flavor] are bitter is flat.[return through] returns liver, spleen, stomach warp.[function cures mainly] clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood tells nosebleed, metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.For multiple hemorrhage and puerperal blood faints.
Herba Equiseti Hiemalis: [nature and flavor] sweetness and bitterness, flat.1. " good blessing book on Chinese herbal medicine ": " sweet and slightly bitter taste is nontoxic." 2. " detailed outline ": " temperature." 3. " book on Chinese herbal medicine is just ": " mildly bitter flavor is micro-sweet." [return through] enters lung, liver, gallbladder meridian.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " Bencao Jingshu ": " enters foot and faints cloudy, few positive two through blood system." 3. " book on Chinese herbal medicine converges and says ": " starts with, the three yang channels of foots." [function cures mainly] wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.
Herba Aeluropi sinensis: [nature and flavor] are sweet；Light；Cool.[function cures mainly] clearing away heat and promoting diuresis, jaundice eliminating.Main icterohepatitis；Liver cirrhosis；Ascites；Cholecystitis.
Radix Isatidis: [nature and flavor] are bitter, cold.[return through] GUIXIN, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.
Rhizoma Smilacis Glabrae: [nature and flavor] are sweet, light is flat.[return through] returns liver, stomach warp.[function cures mainly] dehumidifies, removing toxic substances, easing joint movement.For the limbs contracture caused by damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, syphilis and mercurialism, bones and muscles pain.
Herba Polygoni hydropiperis: [nature and flavor] are pungent, flat.1. " a thousand pieces of gold dietetic therapy ": " pungent." 2. " Japan hanako materia medica ": " acrid in the mouth, cold, nontoxic." 3. " detailed outline ": " Folium Polygonum, pungent, temperature, nontoxic." 4. " book on Chinese herbal medicine asks former ": " is bitter wet, flat." [function cures mainly] removing dampness, row is stagnant, dispels the wind, detumescence.Control the dirty stomachache of acute diseases such as cholera and sunstroke, convulsion of vomiting and diarrhoea, have loose bowels, dysentery, rheumatism, tinea pedis, carbuncle, scabies, traumatic injury.
Radix seu Caulis Buddlejae Asiaticae: [nature and flavor] " Fujian Chinese herbal medicine ": " bitter micro-pungent, temperature." [return through] " east, Fujian book on Chinese herbal medicine ": " enters the heart, kidney, large intestine three warp." [function cures mainly] dispels the wind, removing dampness, dredging collateral, parasite killing.Control wind and cold heating, head-body-pain, articular rheumatic pain, the wet abdominal distention of spleen, dysentery, erysipelas, traumatic injury, abdominal pain due to worm stagnation.
Fructus Viticis Cannabifoliae: [nature and flavor] pungent micro-hardship, temperature, 1. " not record ": " " 2. " detailed outline ": " is pungent for bitter in the mouth, temperature, warm." [return through] " Bencao Jingshu ": " enters foot bright, the JUE YIN meridian of sun." [function cures mainly] dispelling pathogenic wind and eliminating phlegm, the therapeutic method to keep the adverse QI flowing downwards, pain relieving.Control cough, asthma, heatstroke sun stroke, stomach mausoleum, hernia, women leucorrhea.1. " not Lu ": " except cold and heat between bone, tonneau gastric qi, cough-relieving is against the therapeutic method to keep the adverse QI flowing downwards." 2. Zhu Zhenheng: " parching to brown is end drink-service, controls pained and married woman leucorrhea." 3. " traditional Chinese medicines summary ": " controls the spasm of gastrocnemius and the edema of lower limb." 4. " Guangxi Chinese medicinal herbal ": " controls heavy breathing."
Seed of Arillus Longan: [nature and flavor] " Quanzhou book on Chinese herbal medicine ": " puckery." [function cures mainly] stops blooding, and analgesic therapy is regulated the flow of vital energy, removing dampness.Control wound hemorrhage, hernia, scrofula, scabies, eczema.1. " this sketch of the southern regions of the Yunnan Province is said ": " control wart disease.' 2. " Elementary Medicine ": " burn sootiness nose, control watery nasal discharge more than." 3. " detailed outline ": " controls bromhidrosis, and seed of Arillus Longan six pieces grinds with two or seven pieces of Fructus Piperis, meets sweating and i.e. wipes it." 4. " book on Chinese herbal medicine is the newest ": " controls scrofula, and detumescence and apocenosis is drawn out pus by applying a plaster to the affected part.And control mesh expectorant." 5. " south of the Five Ridges gather medicinal herbs record ": " treats hernia, applies skin ulcer tinea, and the most only incised wound is hemorrhage."
Folium rhoeinis: [nature and flavor] are sweet, cool.1. " Luchuan book on Chinese herbal medicine ": " bitter, cold." 2. " Nanning City's medicine will ": " puts down, micro-pungent puckery." 7. " Guangdong Chinese medicine " II: " is sweet light, cool." [function cures mainly] heat clearing away, hemostasis, blood stasis removing.Control lung-heat type cough, spit blood, have blood in stool, hematuria, dysentery, traumatic injury.1. " Luchuan book on Chinese herbal medicine ": " blood stasis removing pain relieving.Controlling dysentery, traumatic injury refutes bone." 2. " Nanning City's medicine will ": " clearing away heat to stop bleeding.Treating hematochezia, hemoptysis, hematuria." 3. " Guangdong Chinese medicine " II: " cough-relieving, hemostasis.Control over-strained hemoptysis, hemoptysis, have blood in stool, phlegm-fire core, dryness of the lung heat syndrome cough."
Radix Elaeagni: [nature and flavor] acid is flat.1. " detailed outline ": " acid, flat, nontoxic." 2. " Fujian traditional herbal medicine ": " is sour and astringent, flat, nontoxic." [function cures mainly] cough-relieving, hemostasis are dispeled the wind, and dampness removing, removing food stagnancy is stagnant, throat.Control cough with asthma, spit blood, spitting of blood, have blood in stool.Menorrhagia, rheumatic arthritis, yellow pox, dysentery, infantile malnutrition, laryngopharynx swelling and pain.
Yucca gloriosa L.: [nature and flavor] are pungent；Micro-hardship；Flat.[function cures mainly] relieving cough and asthma.Main bronchus asthma；Cough.
Cortex Hibisci: [nature and flavor] micro-acid, micro-hardship is cool.[function cures mainly] dispels the wind diuresis, and preventing phlegm from forming and stopping coughing is stopped blooding active, removing toxic substances and promoting tissue regeneration.For oedema due to nephritis, cirrhotic ascites, rheumatalgia, hematmesis due to visceral injury, metrorrhagia, leucorrhea, acute and chronic bronchitis, traumatic injury；Mastitis, furuncle abscess, eczema are controlled in external.
Cizu drips: [source] medical material Ji Yuan: the juice that the stem baking for grass cizu burns and flows out.[nature and flavor] are sweet；Cold.[function cures mainly] removing heat-phlegm；Arresting convulsion relieving restlessness.Main expectorant heat syndrome cough is breathed heavily；Vexed；Infantile convulsion；Middle wind-phlegm fan.
Fructus podophylli emodi: [nature and flavor] 1. " Traditional Chinese Medicine in Sichuan will ": " property is put down, sour-puckery flavor." 2. " Shaanxi Chinese herbal medicine ": " sweet in the mouth, property is put down." [function cures mainly] spleen invigorating, regulates the flow of vital energy, antiabortive.Controlling dysentery stomachache, impairment caused by overstrain cough with asthma, nausea is uneasy, menoxenia, leucorrhea.1. " Traditional Chinese Medicine in Sichuan will ": " astringing intestine to stop diarrhea heat clearing away.Control hygropyretic dysentery, falling inflation of suffering from abdominal pain, leucorrhea." 2. " Shaanxi Chinese herbal medicine ": " spleen invigorating is regulated the flow of vital energy, relieving cough and asthma.Be in harmony impairment caused by overstrain asthma." 3. " Chinese herbal medicine is commonly used in Tibet ": " is antiabortive, controls menoxenia."
Herba Kalimeridis: [nature and flavor] are pungent, bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, removing food stagnancy.For cat fever, cough, acute pharyngitis, tonsillitis, mumps, infectious hepatitis, taste-blindness rate, infantile malnutrition, enteritis, dysentery, spit blood, metrorrhagia, menoxenia；External is controlled furuncle and is swollen and ache, mastitis, traumatic hemorrhage.
The Radix Astragali: [nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
Rhizoma Cibotii: [nature and flavor] are bitter sweet, temperature.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch, Yellow Emperor, a legendary ruler, qi primary, Thunder God, Bian Que: sweet, nontoxic.Li Shi: temperature." 3. " property of medicine opinion "；" bitter in the mouth is pungent, slight fever." [return through] enters liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter kidney, bladder two warp." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, kidney." 3. " book on Chinese herbal medicine is the newest ": " enters the heart, liver, kidney three warp." [function cures mainly] invigorating the liver and kidney, except rheumatism, strong waist foot, profit joint.Control back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, lose and drown, frequent micturition, seminal emission, leucorrhea.1. " herbal classic ": " main back is strong, office's emergency, general arthralgia cold-damp, gonalgia.Quite profit old man." 2. " not Lu ": " treats that losing drowns does not saves, and man's flaccidity of the lower limbs lumbago, ailment said due to cold or exposure drenches dew, few gas mesh, hard ridge, profit pitching, woman's damaging the spleen and stomach, joint weight." 3. " property of medicine opinion ": " controls man's woman's poison wind weak foot, pathogen arthralgia chiefly caused by damp pathogen, and kidney qi is weak, tonification man, stricture of vagina muscles and bones." 4. " detailed outline ": " strong Liver and kidney, strong bone, control wind empty." 5. " beautiful Chinese catalpa medicine solution ": " lets out wet cold removing, plays flaccidity pain relieving, lets out kidney liver dampness, consciousness restoring, bone and muscle strengthening, controls lumbago knee joint pain, and the swollen lower limb of foot is weak, foul leukorrhea of passing out semen." 6. " detailed outline is picked up any lost article from the road ": " gold Rhizoma Cibotii stops all skin ulcer blood and goes out, and controls insensitive impediment, and black person's parasite killing is more imitated." 7. " book on Chinese herbal medicine is the newest ": " hard kidney nourishes blood, QI invigorating."
Fructus Ligustri Lucidi: [nature and flavor] are bitter sweet, flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." [return through] enters liver, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-SHAO YIN." 2. " book on Chinese herbal medicine is the newest ": " enters liver, lung, kidney three warp." [function cures mainly] invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, mesh flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.1. " herbal classic ": " main invigorating middle warmer, settling five organs support spirit, except hundred diseases.Clothes fertilizer is strong for a long time." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " black palpus of hair color, strong rigidity of soft tissues power, take wind of enriching blood more." 3. " detailed outline ": " reinforcing YIN-essence, strong waist knee joint, improving eyesight." 4. " Bencao Jingshu ": " removing heat from blood, benefit blood." 5. " book on Chinese herbal medicine is just ": " yin nourishing gas, Pingyin fire, solve dysphoria with smothery sensation hectic fever due to YIN-deficiency, only sweating due to debility, quench one's thirst, and stranguria with turbid discharge, metrorrhagia, have blood in stool, hematuria, the erosion of vulva, anal fistula pain.Also clearing away liver-fire, can be with improving eyesight arresting lacrimation." 3. " book on Chinese herbal medicine is the newest ": " replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI.Control lumbago and skelalgia, stimulate the menstrual flow and blood."
Rhizoma Polygonati: [nature and flavor] are sweet is flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Ganoderma: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, liver, kidney channel.[function cures mainly] invigorating QI and tranquilization, relieving cough and asthma.
Herba Themedae japonicae fruit: [source] medical material Ji Yuan: for the fruit of grass Herba Themedae japonicae.[nature and flavor] sweet in the mouth；Property flat.[function cures mainly] consolidating superficial resistance arresting sweating.Main night sweat.
Herba avenae fatuae: [another name] wild oat.[source] grass family oat wild oat Avena fatua L. is with all herbal medicine.Spring and summer is gathered, and dries.[nature and flavor] are sweet, flat.[function cures mainly] astringing to arrest bleeding, strengthening superficial resistance to stop perspiration.For spitting blood, metrorrhagia, leucorrhea, have blood in stool, spontaneous perspiration, night sweat.
Rhizoma Alpiniae Officinarum: [nature and flavor] are pungent, heat.[return through] returns spleen, stomach warp.[function cures mainly] warming stomach for dispelling cold, help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Vascular aurantii: [nature and flavor] are bitter is flat.[function cures mainly] dredging collateral, reduces phlegm.For cough with copious phlegm, the breast side of body is had a pain.
Folium Eriobotryae: [nature and flavor] are bitter, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.
Currently preferred only above raw medicinal material prepares.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 decoction
Proportioning: Folium Nelumbinis 10g, Herba Equiseti Hiemalis 8g, Herba Aeluropi sinensis 12g, Radix Isatidis 10g, Rhizoma Smilacis Glabrae 8g, Herba Polygoni hydropiperis 12g, Radix seu Caulis Buddlejae Asiaticae 2g, Fructus Viticis Cannabifoliae 8g, seed of Arillus Longan 5g, Folium rhoeinis 10g, Radix Elaeagni 4g, Yucca gloriosa L. 10g, Cortex Hibisci 8g, cizu drip 7g, Fructus podophylli emodi 1g, Herba Kalimeridis 8g, Radix Astragali 10g, Rhizoma Cibotii 8g, Fructus Ligustri Lucidi 10g, Rhizoma Polygonati 8g, Ganoderma 6g, Herba Themedae japonicae fruit 10g, Herba avenae fatuae 12g, Rhizoma Alpiniae Officinarum 6g, Vascular aurantii 8g and Folium Eriobotryae 10g.
Its preparation method is:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 4cm, soak 5 hours；
Step 2: be placed on fire by purple casserole, after intense fire boils, using slow fire instead and decocting the 40 minutes dosage to medicinal liquid slowly is 200ml, filters, obtains filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 6 hours；
Step 4: be placed on fire by purple casserole, after intense fire boils, using slow fire instead and decocting the 30 minutes dosage to medicinal liquid slowly is 200ml, filters, obtains filtrate b, is mixed by filtrate a and filtrate b and i.e. can get decoction.
Embodiment 2 tablet
Proportioning: Folium Nelumbinis 15g, Herba Equiseti Hiemalis 12g, Herba Aeluropi sinensis 20g, Radix Isatidis 20g, Rhizoma Smilacis Glabrae 15g, Herba Polygoni hydropiperis 20g, Radix seu Caulis Buddlejae Asiaticae 4g, Fructus Viticis Cannabifoliae 15g, seed of Arillus Longan 10g, Folium rhoeinis 15g, Radix Elaeagni 9g, Yucca gloriosa L. 15g, Cortex Hibisci 12g, cizu drip 13g, Fructus podophylli emodi 3g, Herba Kalimeridis 12g, Radix Astragali 20g, Rhizoma Cibotii 13g, Fructus Ligustri Lucidi 15g, Rhizoma Polygonati 13g, Ganoderma 12g, Herba Themedae japonicae fruit 20g, Herba avenae fatuae 23g, Rhizoma Alpiniae Officinarum 12g, Vascular aurantii 13g and Folium Eriobotryae 20g.
Its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 80% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 2 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that the micropowders of 400 mesh；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, starch of 0.2 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to 0.02 times of magnesium stearate of micropowders quality, granulate, tabletting, make.
Embodiment 3 tablet
Proportioning: Folium Nelumbinis 12g, Herba Equiseti Hiemalis 10g, Herba Aeluropi sinensis 16g, Radix Isatidis 15g, Rhizoma Smilacis Glabrae 12g, Herba Polygoni hydropiperis 17g, Radix seu Caulis Buddlejae Asiaticae 3g, Fructus Viticis Cannabifoliae 12g, seed of Arillus Longan 8g, Folium rhoeinis 12g, Radix Elaeagni 8g, Yucca gloriosa L. 12g, Cortex Hibisci 10g, cizu drip 10g, Fructus podophylli emodi 2g, Herba Kalimeridis 10g, Radix Astragali 15g, Rhizoma Cibotii 10g, Fructus Ligustri Lucidi 12g, Rhizoma Polygonati 10g, Ganoderma 8g, Herba Themedae japonicae fruit 16g, Herba avenae fatuae 18g, Rhizoma Alpiniae Officinarum 10g, Vascular aurantii 10g and Folium Eriobotryae 16g.
Its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 2 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that the micropowders of 350 mesh；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.1 times, 0.1 times of lactose, starch of 0.1 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to 0.01 times of magnesium stearate of micropowders quality, granulate, tabletting, make.
The toxicity test of medicine
1. acute toxicity test: with the pharmaceutical composition of the embodiment of the present invention 1 as object, 150 times of clinical consumption per day are offerd medicine to the big enteral of white mouse, are observed 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the present invention does not has toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test: mice is pressed 15,30 and 45g crude drugs/kg continuous use 16 weeks (1.0ml/100g body weight by the pharmaceutical composition of the embodiment of the present invention 2, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Contrast test
Vaccary, Liaocheng cultivation cattle about 1000, has 200 cattle the warm symptom at pulmonary type Bovine Ephemeral Fever occur: disease sees the not aversion to cold that generates heat, rapid breathing, and dyspnea with rapid respiration of coughing, mouth color is scarlet, dry, rough and yellow fur, full and rapid pulse.
Select 200 ill cattle, isolation cultivation, and be randomly divided into four groups, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often group 50.
Embodiment 1 group uses the pharmaceutical composition decoction of the embodiment of the present invention 1 to treat, and is mixed in conventional feed according to the ratio of 4:100 by decoction, normally feeds, carries out 2.
Embodiment 2 groups uses the medicinal composition tablets of the embodiment of the present invention 2 to treat, and is mixed in conventional feed according to the ratio of 4:100 by tablet, normally feeds, carries out 2.
Embodiment 3 groups uses the medicinal composition tablets of the embodiment of the present invention 3 to treat, and is mixed in conventional feed according to the ratio of 4:100 by tablet, normally feeds, carries out 2.
Matched group: use with penicillin, streptomycin, and with medicines such as G/NS, ringer's solution, caffeine and sodium benzoate, vitamin B1 and vitamin Cs, intravenous injection, every day 2 times, conventional feed normally feeds, and carries out 2.
The treatment situation of record experimentation.See table 1.
The average weight of the cattle before and after record experiment, calculates average weight growth pattern.See table 2.
Table 1 is treatment situation contrast (often organizing 50 altogether) of each group
See table 1 can be seen that, healing number and the cure rate of the treatment cattle of embodiment 1 group, embodiment 2 groups and embodiment 3 groups will be higher than the healing number of the cattle of matched group and cure rates, it is appreciated that, the pharmaceutical composition of the present invention, treatment warm is on pulmonary type Bovine Ephemeral Fever, therapeutic effect is good, determined curative effect, well improves the state of an illness.
Table 2 is the balanced growth body weight contrast of the cattle of each group
Group Sum Average weight before experiment Average weight after test Average daily gain
Embodiment group 1 50 532.0kg 535.46kg 1.73kg/d
Embodiment group 2 50 531.2kg 534.86kg 1.83kg/d
Embodiment group 2 50 530.1kg 533.78kg 1.84kg/d
Matched group 50 532.1kg 533.52kg 0.71kg/d
Seeing table 2 it can be seen that the treatment of embodiment 1 group, embodiment 2 groups and embodiment 3 groups warms while pulmonary type Bovine Ephemeral Fever, growth rate will be faster than matched group, maintains the normal growth of cattle.
In sum, pharmaceutical composition of the present invention, in treatment warm on pulmonary type Bovine Ephemeral Fever, therapeutic effect is good, determined curative effect, and ensure that the normal growth of cattle.
Citing: Heze City vaccary cowboying 600, in June, 2014,200 there is warm in pulmonary type Bovine Ephemeral Fever symptom: disease sees the not aversion to cold that generates heat, rapid breathing, and dyspnea with rapid respiration of coughing, mouth color is scarlet, dry, rough and yellow fur, full and rapid pulse.Select 100 ill cattle to carry out isolation treatment, use the medicament composition granule agent of the embodiment of the present invention 2 to treat, granule is mixed in conventional feed according to the ratio of 4:100, normally feeds, carry out 2.Cure for 100, cure rate 100%.Body weight increases 3.4kg during treating.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (4)

  1. null1. treat the warm pharmaceutical composition at pulmonary type Bovine Ephemeral Fever for one kind，It is characterized in that，Prepared by the raw medicinal material of following mass fraction: Folium Nelumbinis 10-15 weight portion、Herba Equiseti Hiemalis's 8-12 weight portion、Herba Aeluropi sinensis 12-20 weight portion、Radix Isatidis 10-20 weight portion、Rhizoma Smilacis Glabrae 8-15 weight portion、Herba Polygoni hydropiperis 12-20 weight portion、Radix seu Caulis Buddlejae Asiaticae 2-4 weight portion、Fructus Viticis Cannabifoliae 8-15 weight portion、Seed of Arillus Longan 5-10 weight portion、Folium rhoeinis 10-15 weight portion、Radix Elaeagni 4-9 weight portion、Yucca gloriosa L. 10-15 weight portion、Cortex Hibisci 8-12 weight portion、Cizu drip 7-13 weight portion、Fructus podophylli emodi 1-3 weight portion、Herba Kalimeridis 8-12 weight portion、Radix Astragali 10-20 weight portion、Rhizoma Cibotii 8-13 weight portion、Fructus Ligustri Lucidi 10-15 weight portion、Rhizoma Polygonati 8-13 weight portion、Ganoderma 6-12 weight portion、Herba Themedae japonicae fruit 10-20 weight portion、Herba avenae fatuae 12-23 weight portion、Rhizoma Alpiniae Officinarum 6-12 weight portion、Vascular aurantii 8-13 weight portion and Folium Eriobotryae 10-20 weight portion.
  2. nullTreatment warm the most according to claim 1 is at the pharmaceutical composition of pulmonary type Bovine Ephemeral Fever，It is characterized in that，The raw medicinal material having following mass fraction prepares: Folium Nelumbinis 12 weight portion、Herba Equiseti Hiemalis 10 weight portion、Herba Aeluropi sinensis 16 weight portion、Radix Isatidis 15 weight portion、Rhizoma Smilacis Glabrae 12 weight portion、Herba Polygoni hydropiperis 17 weight portion、Radix seu Caulis Buddlejae Asiaticae 3 weight portion、Fructus Viticis Cannabifoliae 12 weight portion、Seed of Arillus Longan 8 weight portion、Folium rhoeinis 12 weight portion、Radix Elaeagni 8 weight portion、Yucca gloriosa L. 12 weight portion、Cortex Hibisci 10 weight portion、Cizu drips 10 weight portions、Fructus podophylli emodi 2 weight portion、Herba Kalimeridis 10 weight portion、The Radix Astragali 15 weight portion、Rhizoma Cibotii 10 weight portion、Fructus Ligustri Lucidi 12 weight portion、Rhizoma Polygonati 10 weight portion、Ganoderma 8 weight portion、Herba Themedae japonicae fruit 16 weight portions、Herba avenae fatuae 18 weight portion、Rhizoma Alpiniae Officinarum 10 weight portion、Vascular aurantii 10 weight portion and Folium Eriobotryae 16 weight portion.
  3. Treatment warm the most according to claim 1 and 2 is at the pharmaceutical composition of pulmonary type Bovine Ephemeral Fever, it is characterised in that its preparation method comprises the following steps:
    The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the ethanol that determining alcohol is 80～90% of 4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
    Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 350 mesh～the micropowders of 400 mesh；
    3rd step, the micropowders that second step is obtained, add relative to its quality 0.1～the microcrystalline Cellulose of 0.2 times, 0.05～0.2 times of lactose, starch of 0.1～0.2 times, sieve, mix homogeneously, pelletize, it is dried, adds relative to micropowders quality 0.005～0.02 times of magnesium stearate, granulate, tabletting, makes.
  4. 4. the treatment warm described in an any one of claims 1 to 3 is in the preparation method of the pharmaceutical composition of pulmonary type Bovine Ephemeral Fever, it is characterised in that comprise the following steps:
    The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2～the ethanol that determining alcohol is 80～90% of 4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80～90% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
    Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 350 mesh～the micropowders of 400 mesh；
    3rd step, the micropowders that second step is obtained, add relative to its quality 0.1～the microcrystalline Cellulose of 0.2 times, 0.05～0.2 times of lactose, starch of 0.1～0.2 times, sieve, mix homogeneously, pelletize, it is dried, adds relative to micropowders quality 0.005～0.02 times of magnesium stearate, granulate, tabletting, makes.
CN201610307005.8A 2016-05-11 2016-05-11 Pharmaceutical composition for treating lung pathogenic warm type bovine ephemeral fever and preparation method thereof Withdrawn CN105963609A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104258300A (en) * 2014-10-16 2015-01-07 王传英 Traditional Chinese medicine preparation for treating apoplexy sequela due to vital energy deficiency and blood stasis and preparation method of traditional Chinese medicine preparation

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN104258300A (en) * 2014-10-16 2015-01-07 王传英 Traditional Chinese medicine preparation for treating apoplexy sequela due to vital energy deficiency and blood stasis and preparation method of traditional Chinese medicine preparation

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Title
郑继方等: "《奶牛常见病综合防治技术》", 31 March 2010, 金盾出版社 *

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