CN1698721A - Headache treating Chinese medicine and its preparation method - Google Patents
Headache treating Chinese medicine and its preparation method Download PDFInfo
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- CN1698721A CN1698721A CNA2005100400895A CN200510040089A CN1698721A CN 1698721 A CN1698721 A CN 1698721A CN A2005100400895 A CNA2005100400895 A CN A2005100400895A CN 200510040089 A CN200510040089 A CN 200510040089A CN 1698721 A CN1698721 A CN 1698721A
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Abstract
The invention discloses a headache treating Chinese medicine and its preparation method, which comprises disintegrating rhizoma Gastrodiae, corydalis tuber, Ligusticum wallichii and dahurian angelica root into fines, charging water into batryticated silkworm, notopterygium root, kudzu vine root, achyranthes and cyathula root, bupleurum root for immersion, boiling, filtrating, concentrating the filtrate into grease form, cooling down, mixing the obtained fine medicinal materials with concrete, charging the common excipient, finally preparing various dosage forms of tablet, pill and powder through the conventional preparation making processes.
Description
Technical field
The invention belongs to drug world, especially relate to a kind of Chinese medicine for the treatment of headache.
Background technology
Headache is commonly encountered diseases, the frequently-occurring disease of harm health of people, and cause of disease complexity, clinical manifestation differ, changeful, always be considered as difficult and complicated illness by doctor family.Having a headache, especially migraine is obstinate difficult, and sharp ache causes spirit and sensual very big misery to the patient.According to China's 6 city migraine Epidemiological studys, prevalence is 6.3 ‰.Other has data to show, gender's prevalence respectively is 2.8 and 9.7 ‰, and the women is higher than 3.5 times of male.From sicken age, from the youngest beginning, prevalence increased with the age.Reach the peak in 20-30 year, descend then, old less.
The Chinese and western drugs of treatment headache at present is many, as the indometacin of prostaglandin inhibitor, the Ergotamine of vasoconstrictor, the propranolol of adrenergic receptor blocker, the flunarizine of calcium channel blocker, antiepileptic carbamazepine etc.; The ZHENNAONING of Chinese medicine, ZHENGTIAN WAN etc.The analgesic effect of these Chinese medicine and western medicine is sure, but certain side effect is arranged, and is not suitable for especially taking for a long time.For this reason, some good effects of introduction exploitation, side effect pure Chinese medicinal preparation little, taking convenience are that obvious social and economic benefit are arranged.
Summary of the invention
The Chinese medicine that the purpose of this invention is to provide the little treatment headache of a kind of good effect, side effect.
Another object of the present invention provides a kind of preparation method of Chinese medicine for the treatment of headache.
Technical scheme of the present invention is such: the Chinese medicine of treatment headache comprises following compositions in weight portion: 4～14 parts of Rhizoma Corydalis, 9～19 parts in Rhizoma Gastrodiae, 5～15 parts of Rhizoma Chuanxiongs, 7～17 parts of Bombyx Batryticatus.
The optimum amount ratio of above-mentioned each component is: 9 parts of Rhizoma Corydalis, 14 parts in Rhizoma Gastrodiae, 10 parts of Rhizoma Chuanxiongs, 12 parts of Bombyx Batryticatus.
Also comprise following compositions in weight portion: 7～17 parts of the Radixs Angelicae Dahuricae, 7～17 parts of Rhizoma Et Radix Notopterygiis, 6～16 parts of Radix Puerariaes, 4～14 parts of Radix Achyranthis Bidentataes, 6～16 parts of Radix Bupleuri.
The optimum amount ratio of above-mentioned each component is: 12 parts of the Radixs Angelicae Dahuricae, 12 parts of Rhizoma Et Radix Notopterygiis, 11 parts of Radix Puerariaes, 9 parts of Radix Achyranthis Bidentataes, 11 parts of Radix Bupleuri.
Also comprise and be prepared into the required excipient of common drug preparation.
The preparation method of Chinese medicine of treatment headache, realized by the following step:
1, prepares the Rhizoma Corydalis of 4～14 weight portions, the Rhizoma Gastrodiae of 9～19 weight portions, the Bombyx Batryticatus of the Rhizoma Chuanxiong of 5～15 weight portions and 7～17 weight portions, and be first group of medical material with the Rhizoma Gastrodiae of above-mentioned 9～19 weight portions, the Rhizoma Corydalis of 4～14 weight portions and the Rhizoma Chuanxiong of 5～15 weight portions, be second group of medical material with the Bombyx Batryticatus of above-mentioned 7～17 weight portions;
2, above-mentioned first group of medical material is broken into fine powder, mixing is standby;
3, get above-mentioned second group of medical material and decoct with water, filter, filtrate is concentrated into paste, and cooling is standby;
4, the medical material fine powder mixing in the paste adding step 2 of step 3 gained is got final product.
Above-mentioned first group of medical material also comprises the Radix Angelicae Dahuricae of 7～17 weight portions; Above-mentioned second group of medical material also comprises the Rhizoma Et Radix Notopterygii of 7～17 weight portions, the Radix Puerariae of 6～16 weight portions, the Radix Achyranthis Bidentatae of 4～14 weight portions and the Radix Bupleuri of 6～16 weight portions.
The thick paste adding usual excipients that is mixed with Rhizoma Gastrodiae fine powder of above-mentioned steps 4 gained is made dosage forms such as tablet, pill, powder by conventional method.
Migraine belongs to the traditional Chinese medical science " migraine " category, and is left or right with outbreak repeatedly, and the unexpected severe headache of making a return journey is the headache illness of main performance.Its pathogenesis is a qi and blood stagnation brain network, pathogen upward attacking orifices in head, and cause headache.Control suitable blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, expel wind to dredge collateral.The Chinese medicine of treatment of the present invention headache, in conjunction with practical experience, selecting Rhizoma Chuanxiong for use is monarch drug according to above-mentioned theory of Chinese medical science, gets its warm promoting blood circulation, dredges to reach QI and blood, the up head can blood circulation promoting and blood stasis dispelling, and the merit of activating QI to alleviate the depression is arranged again.Get the Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome, logical blood circulation regulating; The Rhizoma Corydalis wind pain relieving of loosing; Bombyx Batryticatus is expellingged wind and relieving convulsion, and active stimulating the menstrual flow is ministerial drug altogether.Get Radix Puerariae yang invigorating, dispelling wind, pain relieving; Radix Achyranthis Bidentatae stimulates the menstrual flow, invigorates blood circulation, pain relieving; Radix Bupleuri induces sweat, brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, and carries that all medicines are up to be made for assistant altogether.Above-mentioned all medicines share, and play the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, expel wind to dredge collateral altogether, and migraine has significant curative effect to having a headache especially.
Pharmacodynamics test shows, the Chinese medicine that the present invention is a kind of to treat headache to the hemorheological property due to the rat stasis syndrome type " glue ", " dense ", " coagulating " state have obviously and alleviate, and has obvious inhibition rabbit thoracic aortic ring to shrink; Pain reaction to white mice acetic acid twisting method, afterbody electrostimulation and hot plate method cause has the analgesic activity that improves pain threshold; The white mice auricle inflammation swelling that xylol causes, the rat ankle arthroncus that carrageenin causes and rat filter paper bury the chronic granuloma that causes all inhibitory action, simultaneously, certain sedative-hypnotic effect is arranged.These results provide experimental basis for the present invention treats migraine.
Acute and chronic toxicity test shows, a kind of Chinese medicine acute toxicity test for the treatment of headache of the present invention, and Bliss method statistic law is calculated LD
50And L
95Result: LD
50=23.0459gkg
-1(contain crude drug amount 80.661gkg
-1); L
95=20.762gkg
-1(contain crude drug amount 72.667gkg
-1～89.533gkg
-1), illustrate that a kind of Chinese medicine for the treatment of headache of the present invention belongs to nontoxic.Chronic toxicity test is irritated stomach with a kind of Chinese medicine for the treatment of headache of the present invention to rat: 4g, 2g and 1gkg
-1D
-1(contain crude drug 14g, 7g and 3.5gkg
-1D
-1) and normal (ordinary water) matched group.Every day 1 time, continuous 45 days.The result is tried Mus and is not seen toxic reaction, hematological indices, blood parameters, system become celestial and histopathologic examination all no abnormal, the conversion of its high dose is equivalent to 166.7 times of clinical application amount.Therefore, it is without any side effects to human body to think that the present invention treats the Chinese medicine of headache.
The specific embodiment
A kind of Chinese medicine for the treatment of headache of the present invention is made by following medicinal materials: Rhizoma Corydalis 9 grams, Rhizoma Gastrodiae 14 grams, Rhizoma Chuanxiong 10 grams, Bombyx Batryticatus 12 grams, the Radix Angelicae Dahuricae 12 grams, Rhizoma Et Radix Notopterygii 12 grams, Radix Puerariae 11 grams, Radix Bupleuri 11 grams, Radix Achyranthis Bidentatae 9 grams.
A kind of preparation method of Chinese medicine for the treatment of headache of the present invention, realized by following steps:
1, gets Rhizoma Corydalis 9 grams, Rhizoma Gastrodiae 14 grams, Rhizoma Chuanxiong 10 grams, Bombyx Batryticatus 12 grams, the Radix Angelicae Dahuricae 12 grams, Rhizoma Et Radix Notopterygii 12 grams, Radix Puerariae 11 grams, Radix Bupleuri 11 grams, Radix Achyranthis Bidentatae 9 grams; And with above-mentioned 14 the gram Rhizoma Gastrodiaes, 10 the gram Rhizoma Chuanxiongs, 9 the gram Rhizoma Corydalis and 12 the gram Radixs Angelicae Dahuricae be first group of medical material, with above-mentioned 10 the gram Bombyx Batryticatus, 12 the gram Rhizoma Et Radix Notopterygiis, 11 the gram Radix Puerariaes, 9 the gram Radix Achyranthis Bidentataes and 11 the gram Radix Bupleuri be second group of medical material.
2, with above-mentioned first group of medical material in 70 ℃ of oven dry, pulverize, cross the 100# sieve, mix homogeneously, standby.
3, get above-mentioned second group of medical material and place in the pot, add the water retting half an hour of 10 times of amounts, decocted 2 hours, filter, residue adds the water of 8 times of amounts again, decocts 2 hours again, filter, and merging filtrate, heating is evaporated to paste, and cooling is standby.
4, the medical material fine powder of gained in the step 2 is put in the blender, add appropriate amount of starch, abundant mixing, the filtrate that is concentrated into paste and an amount of hydroxypropyl cellulose that add step 3 gained are slowly made granule, in 70 ℃ of oven dry, granulate, the weight that adds as lubricant in every is that granule weighs 1% magnesium stearate, mixing, tabletting, the headache tablets that gets product, every heavily about 0.28 gram.
Usage and consumption: each 2, every day 2 times, one after each meal, oral.
The present invention treats the Chinese medicine of headache, after finishing pharmacy, main pharmacodynamics, toxicologic study work, entrusts Ministry of Public Health Fujian Institute of Traditional Chinese Medicine clinical pharmacology base to carry out clinical preliminary test.Migraineur's 88 examples (test group 55 examples, matched group 33 examples) are made a definite diagnosis in selection, and 15 days courses of treatment, the result shows that the present invention treats the Chinese medicine of headache, cure rate 42%, obvious effective rate 24%, effective percentage 27%, inefficiency 7%, total effective rate 93%.
Model case: Zheng * *, the women, 35 years old, left side headache 6 years was seen and was increased the weight of in nearly one month, outbreak in every 3-5 days once, pain as being stabbed, with dizziness, pale complexion, cold sweat, vomiting, weak, dormancy is poor.Take the Chinese medicine that the present invention treats headache, every day 2 times, each 2 (every heavily about 0.28 gram), and oral, promptly had a headache the same day of taking medicine and obviously alleviated, symptom all disappeared in 5 days, observed again and did not see outbreak in 8 months.
Claims (8)
1, the Chinese medicine of treatment headache is characterized in that: comprise following compositions in weight portion: 4～14 parts of Rhizoma Corydalis, 9～19 parts in Rhizoma Gastrodiae, 5～15 parts of Rhizoma Chuanxiongs, 7～17 parts of Bombyx Batryticatus.
2, the Chinese medicine of treatment headache according to claim 1, it is characterized in that: the optimum amount ratio of above-mentioned each component is: 9 parts of Rhizoma Corydalis, 14 parts in Rhizoma Gastrodiae, 10 parts of Rhizoma Chuanxiongs, 12 parts of Bombyx Batryticatus.
3, the Chinese medicine of treatment headache according to claim 1 is characterized in that: also comprise following compositions in weight portion: 7～17 parts of the Radixs Angelicae Dahuricae, 7～17 parts of Rhizoma Et Radix Notopterygiis, 6～16 parts of Radix Puerariaes, 4～14 parts of Radix Achyranthis Bidentataes, 6～16 parts of Radix Bupleuri.
4, the Chinese medicine of treatment headache according to claim 3, it is characterized in that: the optimum amount ratio of above-mentioned each component is: 12 parts of the Radixs Angelicae Dahuricae, 12 parts of Rhizoma Et Radix Notopterygiis, 11 parts of Radix Puerariaes, 9 parts of Radix Achyranthis Bidentataes, 11 parts of Radix Bupleuri.
5, according to the Chinese medicine of claim 1 or 2 or 3 or 4 described treatment headaches, it is characterized in that: also comprise being prepared into the required excipient of common drug preparation.
6, the preparation method of Chinese medicine of treatment headache is characterized in that: realized by the following step:
(1) Rhizoma Corydalis of preparation 4～14 weight portions, the Rhizoma Gastrodiae of 9～19 weight portions, the Bombyx Batryticatus of the Rhizoma Chuanxiong of 5～15 weight portions and 7～17 weight portions, and be first group of medical material with the Rhizoma Gastrodiae of above-mentioned 9～19 weight portions, the Rhizoma Corydalis of 4～14 weight portions and the Rhizoma Chuanxiong of 5～15 weight portions, be second group of medical material with the Bombyx Batryticatus of above-mentioned 7～17 weight portions;
(2) above-mentioned first group of medical material is broken into fine powder, mixing is standby;
(3) get above-mentioned second group of medical material and decoct with water, filter, filtrate is concentrated into paste, and cooling is standby;
(4) the medical material fine powder mixing in the paste adding step 2 of step 3 gained is got final product.
7, the preparation method of Chinese medicine of treatment headache according to claim 6, it is characterized in that: above-mentioned first group of medical material also comprises the Radix Angelicae Dahuricae of 7～17 weight portions; Above-mentioned second group of medical material also comprises the Rhizoma Et Radix Notopterygii of 7～17 weight portions, the Radix Puerariae of 6～16 weight portions, the Radix Achyranthis Bidentatae of 4～14 weight portions and the Radix Bupleuri of 6～16 weight portions.
8, the preparation method of Chinese medicine of treatment headache according to claim 6 is characterized in that: the thick paste adding usual excipients that is mixed with Rhizoma Gastrodiae fine powder of above-mentioned steps 4 gained is made dosage forms such as tablet, pill, powder by conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100400895A CN100352486C (en) | 2005-05-14 | 2005-05-14 | Headache treating Chinese medicine and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100400895A CN100352486C (en) | 2005-05-14 | 2005-05-14 | Headache treating Chinese medicine and its preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1698721A true CN1698721A (en) | 2005-11-23 |
| CN100352486C CN100352486C (en) | 2007-12-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612326B (en) * | 2009-07-22 | 2011-09-28 | 陶国闻 | Traditional Chinese medicine for diminishing inflammation and alleviating pain and preparation method thereof |
| CN104116932A (en) * | 2014-06-26 | 2014-10-29 | 凤台县中医院 | Traditional Chinese medicine composition for treating intractable headache |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1239193C (en) * | 2004-01-06 | 2006-02-01 | 张福成 | Chinese medicine for treating trigeminal neuralgia and its preparation method |
-
2005
- 2005-05-14 CN CNB2005100400895A patent/CN100352486C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612326B (en) * | 2009-07-22 | 2011-09-28 | 陶国闻 | Traditional Chinese medicine for diminishing inflammation and alleviating pain and preparation method thereof |
| CN104116932A (en) * | 2014-06-26 | 2014-10-29 | 凤台县中医院 | Traditional Chinese medicine composition for treating intractable headache |
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| Publication number | Publication date |
|---|---|
| CN100352486C (en) | 2007-12-05 |
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Granted publication date: 20071205 Termination date: 20130514 |